Po Hu, Jack Rychik, Juanjuan Zhao, Huajun Bai, Aidan Bauer, Wenbao Yu, Elizabeth B Rand, Kathryn M Dodds, David J Goldberg, Kai Tan, Benjamin J Wilkins, Liming Pei
The Fontan operation is the current standard of care for single-ventricle congenital heart disease. Individuals with a Fontan circulation (FC) exhibit central venous hypertension and face life-threatening complications of hepatic fibrosis, known as Fontan-associated liver disease (FALD). The fundamental biology and mechanisms of FALD are little understood. Here, we generated a transcriptomic and epigenomic atlas of human FALD at single-cell resolution using multiomic snRNA-ATAC-seq. We found profound cell type-specific transcriptomic and epigenomic changes in FC livers...
April 24, 2024: Science Translational Medicine