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Superior oliver complex

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https://www.readbyqxmd.com/read/29587795/clinical-outcome-after-particle-therapy-for-meningiomas-of-the-skull-base-toxicity-and-local-control-in-patients-treated-with-active-rasterscanning
#1
Rami A El Shafie, Maja Czech, Kerstin A Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus, Stephanie E Combs
BACKGROUND: Meningiomas of the skull base account for 25-30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantial morbidity. Treatment options include observation, aggressive surgical intervention, stereotactic or conventional radiotherapy. In this analysis we evaluate the outcome of 110 patients with meningiomas of the skull base treated with particle therapy. It was performed within the framework of the "clinical research group heavy ion therapy" and supported by the German Research Council (DFG, KFO 214)...
March 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29559886/extraction-of-inter-aural-time-differences-using-a-spiking-neuron-network-model-of-the-medial-superior-olive
#2
Jörg Encke, Werner Hemmert
The mammalian auditory system is able to extract temporal and spectral features from sound signals at the two ears. One important cue for localization of low-frequency sound sources in the horizontal plane are inter-aural time differences (ITDs) which are first analyzed in the medial superior olive (MSO) in the brainstem. Neural recordings of ITD tuning curves at various stages along the auditory pathway suggest that ITDs in the mammalian brainstem are not represented in form of a Jeffress-type place code. An alternative is the hemispheric opponent-channel code, according to which ITDs are encoded as the difference in the responses of the MSO nuclei in the two hemispheres...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29549526/a-novel-interaction-fingerprint-derived-from-per-atom-score-contributions-exhaustive-evaluation-of-interaction-fingerprint-performance-in-docking-based-virtual-screening
#3
Julia B Jasper, Lina Humbeck, Tobias Brinkjost, Oliver Koch
Protein ligand interaction fingerprints are a powerful approach for the analysis and assessment of docking poses to improve docking performance in virtual screening. In this study, a novel interaction fingerprint approach (PADIF, protein per atom score contributions derived interaction fingerprint) is presented which was specifically designed for utilising the GOLD scoring functions' atom contributions together with a specific scoring scheme. This allows the incorporation of known protein-ligand complex structures for a target-specific scoring...
March 16, 2018: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29453417/exome-sequencing-has-higher-diagnostic-yield-compared-to-simulated-disease-specific-panels-in-children-with-suspected-monogenic-disorders
#4
Oliver James Dillon, Sebastian Lunke, Zornitza Stark, Alison Yeung, Natalie Thorne, Clara Gaff, Susan M White, Tiong Yang Tan
As test costs decline, whole-exome sequencing (WES) has become increasingly used for clinical diagnosis, and now represents the primary alternative to gene panel testing for patients with a suspected genetic disorder. We sought to compare the diagnostic yield of singleton-WES with simulated application of commercial gene panels in children suspected of having a genetically heterogeneous condition. Recruitment, singleton-WES and phenotype-driven variant analysis was completed for 145 paediatric patients. At recruitment, clinicians were required to propose commercial gene panel tests as an alternative to WES and nominate a phenotype-driven candidate gene list...
February 16, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29374830/correlations-between-near-infrared-spectroscopy-perfusion-index-and-cardiac-outputs-in-extremely-preterm-infants-in-the-first-72%C3%A2-h-of-life
#5
Marie Janaillac, Thierry P Beausoleil, Keith J Barrington, Marie-Josée Raboisson, Oliver Karam, Mathieu Dehaes, Anie Lapointe
Haemodynamic assessment during the transitional period in preterm infants is challenging. We aimed to describe the relationships between cerebral regional tissue oxygen saturation (CrSO2), perfusion index (PI), echocardiographic, and clinical parameters in extremely preterm infants in their first 72 h of life. Twenty newborns born at < 28 weeks of gestation were continuously monitored with CrSO2 and preductal PI. Cardiac output was measured at H6, H24, H48, and H72. The median gestational age and birth weight were 25...
January 27, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29354682/neural-correlates-of-temporal-complexity-and-synchrony-during-audiovisual-correspondence-detection
#6
Oliver Baumann, Joyce M G Vromen, Allen Cheung, Jessica McFadyen, Yudan Ren, Christine C Guo
We often perceive real-life objects as multisensory cues through space and time. A key challenge for audiovisual integration is to match neural signals that not only originate from different sensory modalities but also that typically reach the observer at slightly different times. In humans, complex, unpredictable audiovisual streams lead to higher levels of perceptual coherence than predictable, rhythmic streams. In addition, perceptual coherence for complex signals seems less affected by increased asynchrony between visual and auditory modalities than for simple signals...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29281618/physiological-models-of-the-lateral-superior-olive
#7
COMPARATIVE STUDY
Go Ashida, Daniel J Tollin, Jutta Kretzberg
In computational biology, modeling is a fundamental tool for formulating, analyzing and predicting complex phenomena. Most neuron models, however, are designed to reproduce certain small sets of empirical data. Hence their outcome is usually not compatible or comparable with other models or datasets, making it unclear how widely applicable such models are. In this study, we investigate these aspects of modeling, namely credibility and generalizability, with a specific focus on auditory neurons involved in the localization of sound sources...
December 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29200206/discovery-and-characterization-of-highly-potent-and-selective-allosteric-usp7-inhibitors
#8
Gerald Gavory, Colin R O'Dowd, Matthew D Helm, Jakub Flasz, Elias Arkoudis, Anthony Dossang, Caroline Hughes, Eamon Cassidy, Keeva McClelland, Ewa Odrzywol, Natalie Page, Oliver Barker, Hugues Miel, Timothy Harrison
Given the importance of ubiquitin-specific protease 7 (USP7) in oncogenic pathways, identification of USP7 inhibitors has attracted considerable interest. Despite substantial efforts, however, the development of validated deubiquitinase (DUB) inhibitors that exhibit drug-like properties and a well-defined mechanism of action has proven particularly challenging. In this article, we describe the identification, optimization and detailed characterization of highly potent (IC50 < 10 nM), selective USP7 inhibitors together with their less active, enantiomeric counterparts...
February 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29073893/activity-dependent-formation-of-a-vesicular-inhibitory-amino-acid-transporter-gradient-in-the-superior-olivary-complex-of-nmri-mice
#9
Lena Ebbers, Maren Weber, Hans Gerd Nothwang
BACKGROUND: In the mammalian superior olivary complex (SOC), synaptic inhibition contributes to the processing of binaural sound cues important for sound localization. Previous analyses demonstrated a tonotopic gradient for postsynaptic proteins mediating inhibitory neurotransmission in the lateral superior olive (LSO), a major nucleus of the SOC. To probe, whether a presynaptic molecular gradient exists as well, we investigated immunoreactivity against the vesicular inhibitory amino acid transporter (VIAAT) in the mouse auditory brainstem...
October 26, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28737505/androgen-mediated-sex-bias-impairs-efficiency-of-leukotriene-biosynthesis-inhibitors-in-males
#10
Simona Pace, Carlo Pergola, Friederike Dehm, Antonietta Rossi, Jana Gerstmeier, Fabiana Troisi, Helmut Pein, Anja M Schaible, Christina Weinigel, Silke Rummler, Hinnak Northoff, Stefan Laufer, Thorsten J Maier, Olof Rådmark, Bengt Samuelsson, Andreas Koeberle, Lidia Sautebin, Oliver Werz
Proinflammatory leukotrienes (LTs) are produced by 5-lipoxygenase (5-LO) aided by 5-LO-activating protein (FLAP). LT biosynthesis inhibitors are currently under clinical investigation as treatments for respiratory and cardiovascular diseases. Here, we have revealed a sex bias in the efficiency of clinically relevant LT biosynthesis inhibitors, showing that their effects are superior in females. We found that androgens cause these sex differences by impeding the LT-biosynthetic 5-LO/FLAP complex assembly. Lower doses of the FLAP inhibitor MK886 were required to reduce LTB4 levels in exudates of female versus male mice and rats...
August 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28701535/enhancement-of-phase-locking-in-rodents-i-an-axonal-recording-study-in-gerbil
#11
Liting Wei, Shotaro Karino, Eric Verschooten, Philip X Joris
The trapezoid body (TB) contains axons of neurons in the anteroventral cochlear nucleus projecting to monaural and binaural nuclei in the superior olivary complex (SOC). Characterization of these monaural inputs is important for the interpretation of response properties of SOC neurons. In particular, understanding of the sensitivity to interaural time differences (ITDs) in neurons of the medial and lateral superior olive requires knowledge of the temporal firing properties of the monaural excitatory and inhibitory inputs to these neurons...
October 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28659467/motor-learning-in-a-complex-balance-task-and-associated-neuroplasticity-a-comparison-between-endurance-athletes-and-nonathletes
#12
Oliver Seidel, Daniel Carius, Rouven Kenville, Patrick Ragert
Studies suggested that motor expertise is associated with functional and structural brain alterations, which positively affect sensorimotor performance and learning capabilities. The purpose of the present study was to unravel differences in motor skill learning and associated functional neuroplasticity between endurance athletes (EA) and nonathletes (NA). For this purpose, participants had to perform a multimodal balance task (MBT) training on 2 sessions, which were separated by 1 wk. Before and after MBT training, a static balance task (SBT) had to be performed...
September 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28633959/characterization-of-the-superior-olivary-complex-of-canis-lupus-domesticus
#13
Tatiana Fech, Lilian Calderón-Garcidueñas, Randy J Kulesza
The superior olivary complex (SOC) is a collection of brainstem auditory nuclei which play essential roles in the localization of sound sources, temporal coding of vocalizations and descending modulation of the cochlea. Notwithstanding, the SOC nuclei vary considerably between species in accordance with the auditory needs of the animal. The canine SOC was subjected to anatomical and physiological examination nearly 50 years ago and was then virtually forgotten. Herein, we aimed to characterize the nuclei of the canine SOC using quantitative morphometrics, estimation of neuronal number, histochemistry for perineuronal nets and immunofluorescence for the calcium binding proteins calbindin and calretinin...
August 2017: Hearing Research
https://www.readbyqxmd.com/read/28417171/resolution-optimized-headspace-gas-chromatography-ion-mobility-spectrometry-hs-gc-ims-for-non-targeted-olive-oil-profiling
#14
Natalie Gerhardt, Markus Birkenmeier, Daniel Sanders, Sascha Rohn, Philipp Weller
A prototype gas chromatography-ion mobility spectrometry (GC-IMS) system, hyphenating temperature-ramped headspace GC to a modified drift time IMS cell, was evaluated and compared to a conventional, isothermal capillary column (CC)-IMS system on the example of the geographical differentiation of extra virgin olive oils (EVOO) from Spain and Italy. It allows orthogonal, 2D separation of complex samples and individual detection of compounds in robust and compact benchtop systems. The information from the high-resolution 3D fingerprints of volatile organic compound (VOC) fractions of EVOO samples were extracted by specifically developed chemometric MATLAB® routines to differentiate between the different olive oil provenances...
June 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28405498/cergutuzumab-amunaleukin-cea-il2v-a-cea-targeted-il-2-variant-based-immunocytokine-for-combination-cancer-immunotherapy-overcoming-limitations-of-aldesleukin-and-conventional-il-2-based-immunocytokines
#15
Christian Klein, Inja Waldhauer, Valeria G Nicolini, Anne Freimoser-Grundschober, Tapan Nayak, Danielle J Vugts, Claire Dunn, Marije Bolijn, Jörg Benz, Martine Stihle, Sabine Lang, Michaele Roemmele, Thomas Hofer, Erwin van Puijenbroek, David Wittig, Samuel Moser, Oliver Ast, Peter Brünker, Ingo H Gorr, Sebastian Neumann, Maria Cristina de Vera Mudry, Heather Hinton, Flavio Crameri, Jose Saro, Stefan Evers, Christian Gerdes, Marina Bacac, Guus van Dongen, Ekkehard Moessner, Pablo Umaña
We developed cergutuzumab amunaleukin (CEA-IL2v, RG7813), a novel monomeric CEA-targeted immunocytokine, that comprises a single IL-2 variant (IL2v) moiety with abolished CD25 binding, fused to the C-terminus of a high affinity, bivalent carcinoembryonic antigen (CEA)-specific antibody devoid of Fc-mediated effector functions. Its molecular design aims to (i) avoid preferential activation of regulatory T-cells vs. immune effector cells by removing CD25 binding; (ii) increase the therapeutic index of IL-2 therapy by (a) preferential retention at the tumor by having a lower dissociation rate from CEA-expressing cancer cells vs...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28396281/the-neural-pathway-for-lacrimal-gland-tear-secretion-in-new-zealand-white-rabbits
#16
Jiaojiao Wang, Rongyi Zhou, Weiping Gao
OBJECTIVE: We investigated the neural pathway for tear secretion from the lacrimal gland of New Zealand White rabbits. METHODS: Nine healthy adult New Zealand White rabbits were randomly divided into three experimental groups, namely, an irritant-stimulated group, a non-stimulated group, and a saline-stimulated group. Sanitized dry cotton swabs with menthol were used to wipe both of the rabbits' eyelids in the irritant-stimulated group, and the non-stimulated group and saline- stimulated group were compared as controls...
April 7, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27872295/characterization-of-the-heterooligomeric-red-type-rubisco-activase-from-red-algae
#17
Nitin Loganathan, Yi-Chin Candace Tsai, Oliver Mueller-Cajar
The photosynthetic CO2-fixing enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (rubisco) is inhibited by nonproductive binding of its substrate ribulose-1,5-bisphosphate (RuBP) and other sugar phosphates. Reactivation requires ATP-hydrolysis-powered remodeling of the inhibited complexes by diverse molecular chaperones known as rubisco activases (Rcas). Eukaryotic phytoplankton of the red plastid lineage contain so-called red-type rubiscos, some of which have been shown to possess superior kinetic properties to green-type rubiscos found in higher plants...
December 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27832380/endoscopic-approach-routes-in-the-posterior-fossa-cisterns-through-the-retrosigmoid-keyhole-craniotomy-an-anatomical-study
#18
Peter Kurucz, Gabor Baksa, Lajos Patonay, Firas Thaher, Michael Buchfelder, Oliver Ganslandt
Endoscopy in cerebellopontine angle surgery is an increasingly used technique. Despite of its advantages, the shortcomings arising from the complex anatomy of the posterior fossa are still preventing its widespread use. To overcome these drawbacks, the goal of this study was to define the anatomy of different endoscopic approaches through the retrosigmoid craniotomy and their limitations by surgical windows. Anatomical dissections were performed on 25 fresh human cadavers to describe the main approach-routes...
July 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/27793590/individual-differences-in-children-s-global-motion-sensitivity-correlate-with-tbss-based-measures-of-the-superior-longitudinal-fasciculus
#19
Oliver Braddick, Janette Atkinson, Natacha Akshoomoff, Erik Newman, Lauren B Curley, Marybel Robledo Gonzalez, Timothy Brown, Anders Dale, Terry Jernigan
Reduced global motion sensitivity, relative to global static form sensitivity, has been found in children with many neurodevelopmental disorders, leading to the "dorsal stream vulnerability" hypothesis (Braddick et al., 2003). Individual differences in typically developing children's global motion thresholds have been shown to be associated with variations in specific parietal cortical areas (Braddick et al., 2016). Here, in 125 children aged 5-12years, we relate individual differences in global motion and form coherence thresholds to fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF), a major fibre tract communicating between parietal lobe and anterior cortical areas...
December 2017: Vision Research
https://www.readbyqxmd.com/read/27754244/os-35-04-the-aa2-ratio-towards-improved-screening-for-primary-aldosteronism-in-hypertension
#20
Marko Poglitsch, Ashraf H Ahmed, Michael Resl, Andrea Stoller, Dunja Van Oyen, Cornelia Schwager, Claudia Aigner, Oliver Domenig, Michael Krebs, Manuel Haschke, Michael Stowasser
OBJECTIVE: Primary aldosteronism (PA) is form of hypertension characterized by production of aldosterone by the adrenal that is excessive and relatively autonomous of the renin-angiotensin system. Once detected, unilateral PA can be usually cured by surgical removal of the affected adrenal, while bilateral PA can be specifically treated by medications, which antagonize aldosterone action. Clinical guidelines of Endocrine Societies in Europe and the US recommend screening for PA among most hypertensive patients...
September 2016: Journal of Hypertension
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