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https://www.readbyqxmd.com/read/28918366/a-progressive-reduction-in-autophagic-capacity-contributes-to-induction-of-replicative-senescence-in-hs68-cells
#1
Byeal-I Han, Sung-Hee Hwang, Michael Lee
Autophagy has been implicated in delayed aging and extended longevity. Here, we aimed to study the possible effects of autophagy during the progression of replicative senescence, which is one of the major features of aging. Human foreskin fibroblasts, Hs68 cells, at an initial passage of 15 were serially cultured for several months until they reached cellular senescence. A decrease in cell proliferation was observed during the progression of senescence. Induction of replicative senescence in aged cells (at passage 40) was confirmed by senescence-associated β-galactosidase (SA-β-gal) activity that represents a sensitive and reliable marker for quantifying senescent cells...
September 13, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28918280/from-sport-hunting-to-breeding-success-patterns-of-lead-ammunition-ingestion-and-its-effects-on-an-endangered-raptor
#2
José M Gil-Sánchez, Saray Molleda, José A Sánchez-Zapata, Jesús Bautista, Isabel Navas, Raquel Godinho, Antonio J García-Fernández, Marcos Moleón
Lead is highly toxic for wildlife, with pernicious consequences especially in long-lived predators. The causes of lead ammunition ingestion in Bonelli's eagle (Aquila fasciata) and its effects on breeding success were studied in one of the most important populations of this endangered species in Europe. Regurgitated pellets belonging to different pairs from 2004 to 2014 were analyzed, both in the breeding (1363 pellets from 12 territories) and non-breeding (172 pellets from 9 territories) seasons. From these territories, 57 molted feathers to study lead contamination were analyzed, and breeding success was monitored for 41 breeding attempts...
September 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28915506/maternal-diethylhexyl-phthalate-exposure-affects-adiposity-and-insulin-tolerance-in-offspring-in-a-pcna-dependent-manner
#3
Brian G Hunt, Yuan-Liang Wang, Min-Shan Chen, Shao-Chun Wang, Susan E Waltz
The ubiquitous plasticizer, diethylhexyl phthalate (DEHP), is a known endocrine disruptor. However, DEHP exposure effects are not well understood. Changes in industrial and agricultural practices have resulted in increased prevalence of DEHP exposure and has coincided with the heightened occurrence of metabolic syndrome and obesity. DEHP and its metabolites are detected in the umbilical cord blood of newborns; however, the prenatal and perinatal effects of DEHP exposure have not been intensively studied. Previously, we discovered that phosphorylation (p) of proliferating cell nuclear antigen (PCNA) at tyrosine 114 (Y114) is required for adipogenesis and diet-induced obesity in mice...
September 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/28912757/in-situ-occurrence-prevalence-and-dynamics-of-parvilucifera-parasitoids-during-recurrent-blooms-of-the-toxic-dinoflagellate-alexandrium-minutum
#4
Elisabet Alacid, Albert Reñé, Jordi Camp, Esther Garcés
Dinoflagellate blooms are natural phenomena that often occur in coastal areas, which in addition to their large number of nutrient-rich sites are characterized by highly restricted hydrodynamics within bays, marinas, enclosed beaches, and harbors. In these areas, massive proliferations of dinoflagellates have harmful effects on humans and the ecosystem. However, the high cell density reached during blooms make them vulnerable to parasitic infections. Under laboratory conditions parasitoids are able to exterminate an entire host population...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28904779/discriminating-patterns-and-drivers-of-multiscale-movement-in-herpetofauna-the-dynamic-and-changing-environment-of-the-mojave-desert-tortoise
#5
Giancarlo Sadoti, Miranda E Gray, Matthew L Farnsworth, Brett G Dickson
Changes to animal movement in response to human-induced changes to the environment are of growing concern in conservation. Most research on this problem has focused on terrestrial endotherms, but changes to herpetofaunal movement are also of concern given their limited dispersal abilities and specialized thermophysiological requirements. Animals in the desert region of the southwestern United States are faced with environmental alterations driven by development (e.g., solar energy facilities) and climate change...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28902903/visuo-perceptual-capabilities-predict-sensitivity-for-coinciding-auditory-and-visual-transients-in-multi-element-displays
#6
Hauke S Meyerhoff, Nina A Gehrer
In order to obtain a coherent representation of the outside world, auditory and visual information are integrated during human information processing. There is remarkable variance among observers in the capability to integrate auditory and visual information. Here, we propose that visuo-perceptual capabilities predict detection performance for audiovisually coinciding transients in multi-element displays due to severe capacity limitations in audiovisual integration. In the reported experiment, we employed an individual differences approach in order to investigate this hypothesis...
2017: PloS One
https://www.readbyqxmd.com/read/28902163/infants-and-children-s-salt-taste-perception-and-liking-a-review
#7
REVIEW
Djin G Liem
Sodium is an essential nutrient for the human body. It is widely used as sodium chloride (table salt) in (processed) foods and overconsumed by both children and adults, placing them at risk for adverse health effects such as high blood pressure and cardiovascular diseases. The current review focusses on the development of salt taste sensitivity and preferences, and its association with food intake. Three -to- four month old infants are able to detect and prefer sodium chloride solutions over plain water, which is thought to be a biological unlearned response...
September 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28899619/first-do-the-experiment-do-computerised-interpretation-of-cardiotocography-and-other-widely-used-interventions-improve-newborn-outcomes
#8
REVIEW
Philip Steer
The introduction of continuous electronic fetal heart rate monitoring (EFM) in labour has coincided with a steady and remarkable fall in perinatal mortality. Whether this is cause or coincidence remains unclear because randomised trials have been underpowered. Attempts to improve the sensitivity and specificity of fetal compromise detection using fetal blood sampling and pH measurement, pulse oximetry, and fetal electrocardiogram analysis have failed to provide evidence of additional value in randomised trials...
September 9, 2017: Early Human Development
https://www.readbyqxmd.com/read/28889185/statistical-approach-to-quality-assessment-in-liver-transplantation
#9
Harald Schrem, Sophia Volz, Hans-Friedrich Koch, Jill Gwiasda, Priscila Kürsch, Alon Goldis, Daniel Pöhnert, Markus Winny, Jürgen Klempnauer, Alexander Kaltenborn
PURPOSE: This study investigated the utility of retrospective two one-sided cumulative sum (CUSUM) charts combined with multivariable regression analysis in liver transplantation for transplant center benchmarking. METHODS: One thousand seven hundred and forty-nine consecutive adult primary liver transplants (January 1, 1983 to December 31, 2012) were analyzed retrospectively with two one-sided CUSUM chart analysis of 90-day mortality. RESULTS: Three eras and two subseries in latest era 3 were identified due to graphically delineated relevant shifts in mean 90-day mortality...
September 9, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28883440/mechanism-and-dna-based-detection-of-field-evolved-resistance-to-transgenic-bt-corn-in-fall-armyworm-spodoptera-frugiperda
#10
Rahul Banerjee, James Hasler, Robert Meagher, Rodney Nagoshi, Lucas Hietala, Fangneng Huang, Kenneth Narva, Juan Luis Jurat-Fuentes
Evolution of resistance threatens sustainability of transgenic crops producing insecticidal proteins from the bacterium Bacillus thuringiensis (Bt). The fall armyworm (Spodoptera frugiperda) is a devastating pest of corn in the Western Hemisphere initially controlled by transgenic Bt corn producing the Cry1Fa insecticidal protein (event TC1507). However field-evolved resistance to TC1507 was observed in Puerto Rico in 2007 and has subsequently been reported in a number of locations in North and South America...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878058/a-vertebrate-retina-with-segregated-colour-and-polarization-sensitivity
#11
Iñigo Novales Flamarique
Besides colour and intensity, some invertebrates are able to independently detect the polarization of light. Among vertebrates, such separation of visual modalities has only been hypothesized for some species of anchovies whose cone photoreceptors have unusual ultrastructure that varies with retinal location. Here, I tested this hypothesis by performing physiological experiments of colour and polarization discrimination using the northern anchovy, Engraulis mordax Optic nerve recordings showed that the ventro-temporal (VT), but not the ventro-nasal (VN), retina was polarization sensitive, and this coincided with the exclusive presence of polarization-sensitive photoreceptors in the VT retina...
September 13, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28876302/seroprevalence-of-chlamydia-trachomatis-in-inner-city-children-and-adolescents-implications-for-vaccine-development
#12
Natalie Banniettis, Sirisha Thumu, Jeremy Weedon, Kobkul Chotikanatis, Aviva Szigeti, Margaret R Hammerschlag, Stephan A Kohlhoff
BACKGROUND: Prevention of Chlamydia trachomatis infection is an ideal application for a vaccine program, which should optimally be administered before sexual debut. However, there are limited epidemiologic studies of C. trachomatis infection in an unselected pediatric population since routine screening and treatment of pregnant women was implemented in the United States in 1993. METHODS: Anonymized serum samples were obtained from children younger than 21 years in 2 medical centers in Brooklyn, New York, from 2013 to 2015...
July 19, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28875244/improving-fab-fragment-retention-in-an-autonucleolytic-escherichia-coli-strain-by-swapping-periplasmic-nuclease-translocation-signal-from-ompa-to-dsba
#13
Desmond M Schofield, Ernestas Sirka, Eli Keshavarz-Moore, John M Ward, Darren N Nesbeth
OBJECTIVES: To reduce unwanted Fab' leakage from an autonucleolytic Escherichia coli strain, which co-expresses OmpA-signalled Staphylococcal nuclease and Fab' fragment in the periplasm, by substituting in Serratial nuclease and the DsbA periplasm translocation signal as alternatives. RESULTS: We attempted to genetically fuse a nuclease from Serratia marcescens to the OmpA signal peptide but plasmid construction failed, possibly due to toxicity of the resultant nuclease...
September 5, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28867596/relationship-between-aluminum-stress-and-caffeine-biosynthesis-in-suspension-cells-of-coffea-arabica-l
#14
Roberto Pech-Kú, J Armando Muñoz-Sánchez, Miriam Monforte-González, Felipe Vázquez-Flota, Beatriz A Rodas-Junco, Víctor M González-Mendoza, S M Teresa Hernández-Sotomayor
Toxicity by aluminum is a growth-limiting factor in plants cultivated in acidic soils. This metal also promotes signal transduction pathways leading to the biosynthesis of defense compounds, including secondary metabolites. In this study, we observed that Coffea arabica L. cells that were kept in the dark did not produce detectable levels of caffeine. However, irradiation with light and supplementation of the culture medium with theobromine were the best conditions for cell maintenance to investigate the role of aluminum in caffeine biosynthesis...
July 29, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28867348/cellular-computations-underlying-detection-of-gaps-in-sounds-and-lateralizing-sound-sources
#15
REVIEW
Donata Oertel, Xiao-Jie Cao, James R Ison, Paul D Allen
In mammals, acoustic information arises in the cochlea and is transmitted to the ventral cochlear nuclei (VCN). Three groups of VCN neurons extract different features from the firing of auditory nerve fibers and convey that information along separate pathways through the brainstem. Two of these pathways process temporal information: octopus cells detect coincident firing among auditory nerve fibers and transmit signals along monaural pathways, and bushy cells sharpen the encoding of fine structure and feed binaural pathways...
August 31, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28865242/novel-graphene-based-biosensor-for-early-detection-of-zika-virus-infection
#16
Savannah Afsahi, Mitchell B Lerner, Jason M Goldstein, Joo Lee, Xiaoling Tang, Dennis A Bagarozzi, Deng Pan, Lauren Locascio, Amy Walker, Francie Barron, Brett R Goldsmith
We have developed a cost-effective and portable graphene-enabled biosensor to detect Zika virus with a highly specific immobilized monoclonal antibody. Field Effect Biosensing (FEB) with monoclonal antibodies covalently linked to graphene enables real-time, quantitative detection of native Zika viral (ZIKV) antigens. The percent change in capacitance in response to doses of antigen (ZIKV NS1) coincides with levels of clinical significance with detection of antigen in buffer at concentrations as low as 450pM...
August 24, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28865212/indirect-enzyme-linked-immunosorbent-assay-method-based-on-streptococcus-agalactiae-rsip-pgk-fbsa-fusion-protein-for-detection-of-bovine-mastitis
#17
Ri-E Bu, Jin-Liang Wang, Jin-Hua Wu, Gao-Wa Xilin, Jin-Long Chen, Hua Wang
OBJECTIVE: The aim of this study was to establish a rapid and accurate method for the detection of the Streptococcus agalactiae antibody (SA-Ab) to determine the presence of the bovine mastitis (BM)-causative pathogen. METHODS: The multi-subunit fusion protein rSip-Pgk-FbsA was prokaryotically expressed and purified. The triple activities of the membrane surface-associated proteins Sip, phosphoglycerate kinase (Pgk), and fibronectin (FbsA) were used as the diagnostic antigens to establish an indirect enzyme-linked immunosorbent assay (ELISA) method for the detection of SA-Ab in BM...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28863653/sine-wave-gating-silicon-single-photon-detectors-for-multiphoton-entanglement-experiments
#18
Nan Zhou, Wen-Hao Jiang, Luo-Kan Chen, Yu-Qiang Fang, Zheng-Da Li, Hao Liang, Yu-Ao Chen, Jun Zhang, Jian-Wei Pan
Silicon single-photon detectors (SPDs) are the key devices for detecting single photons in the visible wavelength range. Here we present high detection efficiency silicon SPDs dedicated to the generation of multiphoton entanglement based on the technique of high-frequency sine wave gating. The silicon single-photon avalanche diode components are acquired by disassembling 6 commercial single-photon counting modules (SPCMs). Using the new quenching electronics, the average detection efficiency of SPDs is increased from 68...
August 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28856044/label-free-optical-detection-of-action-potential-in-mammalian-neurons
#19
Subrata Batabyal, Sarmishtha Satpathy, Loan Bui, Young-Tae Kim, Samarendra Mohanty, Robert Bachoo, Digant P Davé
We describe an optical technique for label-free detection of the action potential in cultured mammalian neurons. Induced morphological changes due to action potential propagation in neurons are optically interrogated with a phase sensitive interferometric technique. Optical recordings composed of signal pulses mirror the electrical spike train activity of individual neurons in a network. The optical pulses are transient nanoscale oscillatory changes in the optical path length of varying peak magnitude and temporal width...
August 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28853253/-establishment-of-a-high-sensitive-indirect-elisa-for-detecting-specific-antibodies-against-h9-subtype-avian-influenza-virus
#20
Wei Zhang, Lidan Hou, Jie Song, Shuang Zhang, Yun Li, Jing Li, Lei Sun, Wenhui Fan, Wenjun Liu
H9 subtype avian influenza virus causes worldwide epidemic, resulting in enormous economic losses of poultry production. In the present study, an indirect ELISA method was established for more accurate and specific detection. The recombinant protein of the globular head domain of HA of H9 subtype avian influenza virus was used as antigen. Specific blocking buffers and dilution buffers were determined to increase the sensitivity and specificity. The sensitivity of ELISA was higher than that of hemagglutination inhibition (HI) test...
August 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
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