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https://www.readbyqxmd.com/read/27914174/mathematical-detection-of-aortic-valve-opening-b-point-in-impedance-cardiography-a-comparison-of-three-popular-algorithms
#1
Javier Rodríguez Árbol, Pandelis Perakakis, Alba Garrido, José Luis Mata, M Carmen Fernández-Santaella, Jaime Vila
The preejection period (PEP) is an index of left ventricle contractility widely used in psychophysiological research. Its computation requires detecting the moment when the aortic valve opens, which coincides with the B point in the first derivative of impedance cardiogram (ICG). Although this operation has been traditionally made via visual inspection, several algorithms based on derivative calculations have been developed to enable an automatic performance of the task. However, despite their popularity, data about their empirical validation are not always available...
December 3, 2016: Psychophysiology
https://www.readbyqxmd.com/read/27913186/protein-kinase-a-activation-by-retinoic-acid-in-the-nuclei-of-hl60-cells
#2
Asako Sakai, Masahiko Imai, Katsuhiko Takahashi, Shinya Hasegawa, Masahiro Yamasaki, Toshihiro Ohba, Noriko Takahashi
BACKGROUND: Activation of protein kinase A (PKA) occurs during retinoic acid (RA)-induced granulocytic differentiation of human promyelocytic leukemia HL60 cells. It is known that the RIIα regulatory subunit of PKA, is modified by RA (retinoylated) in the early stages of differentiation. We have investigated the effects of RA on PKA during cell differentiation in order to understand the potential significance of this process in the retinoylation of RIIα subunits. METHODS: Immunoblotting, immunoprecipitation, confocal microscopy, PCR, and PKA activity assays were employed for characterizing the effects of RA on PKA...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27912792/evaluation-of-natural-porcine-circovirus-type-2-pcv2-subclinical-infection-and-seroconversion-dynamics-in-piglets-vaccinated-at-different-ages
#3
Salvador Oliver-Ferrando, Joaquim Segalés, Sergio López-Soria, Antonio Callén, Olivier Merdy, François Joisel, Marina Sibila
This study aimed to determine the porcine circovirus type 2 (PCV2) serological and virological dynamics in piglets vaccinated at different ages in a PCV2 subclinical infection (PCV2-SI) scenario. Six hundred and forty-four 2 week-old healthy piglets were selected and distributed into four treatment groups: vaccination at 3, 6 or 10 weeks of age (3W-VAC, 6W-VAC and 10W-VAC groups, respectively) and unvaccinated pigs (NON-VAC group). Blood (n = 112 pigs) and oral fluid (OF) (n = 40 pens) samples were taken throughout the study to assess PCV2 load, humoral immunity and viral genotyping...
December 3, 2016: Veterinary Research
https://www.readbyqxmd.com/read/27910525/application-of-the-coincidence-counting-technique-to-dd-neutron-spectrometry-data-at-the-nif-omega-and-z
#4
B Lahmann, L M Milanese, W Han, M Gatu Johnson, F H Séguin, J A Frenje, R D Petrasso, K D Hahn, B Jones
A compact neutron spectrometer, based on a CH foil for the production of recoil protons and CR-39 detection, is being developed for the measurements of the DD-neutron spectrum at the NIF, OMEGA, and Z facilities. As a CR-39 detector will be used in the spectrometer, the principal sources of background are neutron-induced tracks and intrinsic tracks (defects in the CR-39). To reject the background to the required level for measurements of the down-scattered and primary DD-neutron components in the spectrum, the Coincidence Counting Technique (CCT) must be applied to the data...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908226/high-coincidence-of-chronic-lymphocytic-leukemia-and-myeloproliferative-neoplasms-detection-bias-or-a-clue-to-a-common-pathophysiological-path
#5
Claire van de Ree-Pellikaan, Lina van der Straten, Jurgen A Riedl, Mark-David Levin, Peter E Westerweel
No abstract text is available yet for this article.
December 2, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27903638/techniques-to-identify-and-temporally-correlate-calcium-transients-between-multiple-regions-of-interest-in-vertebrate-neural-circuits
#6
Julian Sorrensen, Lukasz Wiklendt, Tim James Hibberd, Marcello C Costa, Nick J Spencer
Calcium imaging is commonly used to record dynamic changes in excitability from axons or cell bodies in the nervous system of vertebrates. These recordings often reveal discrete calcium transients which have variable amplitudes, durations, and rates-of-rise and decay, all of which can arise from an unstable, or "noisy" baseline. This often leads to considerable ambiguity about how to discriminate and quantify calcium transients. We describe an analytical methodology that objectively identifies multiple calcium transients from multiple recording sites and quantifies the degree of temporal synchrony between each event...
November 30, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27902403/the-non-canonical-tomato-yellow-leaf-curl-virus-recombinant-that-displaced-its-parental-viruses-in-southern-morocco-exhibits-a-high-selective-advantage-in-experimental-conditions
#7
Zineb Belabess, Michel Peterschmitt, Martine Granier, Abdessalem Tahiri, Abdelali Blenzar, Cica Urbino
Recombination events are frequently inferred from the increasing number of sequenced viral genomes, but their impact on natural viral populations has rarely been evidenced. TYLCV-IS76 is a recombinant (Begomovirus, Geminiviridae) between the Israel strain of Tomato yellow leaf curl virus (TYLCV-IL) and the Spanish strain of Tomato yellow leaf curl Sardinia virus (TYLCSV-ES) that was generated most probably in the late 1990s in Southern Morocco (Souss). Its emergence in the 2000s coincided with the increasing use of resistant tomato cultivars bearing the Ty-1 gene, and led eventually to the entire displacement of both parental viruses in the Souss...
October 14, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902357/pathogenesis-of-senecavirus-a-infection-in-finishing-pigs
#8
Lok R Joshi, Maureen H V Fernandes, Travis Clement, Steven Lawson, Angela Pillatzki, Talita P Resende, Fabio Vanucci, Gerald F Kutish, Eric Nelson, Diego G Diel
Senecavirus A (SVA) is an emerging picornavirus that has been recently associated with vesicular disease and neonatal mortality in swine. Many aspects of SVA infection biology and pathogenesis, however, remain unknown. Here the pathogenesis of SVA was investigated in finishing pigs. Animals were inoculated via the oronasal route with a contemporary SVA strain SD15-26 and monitored for clinical signs and lesions associated with SVA infection. Viremia was assessed in serum and virus shedding monitored in oral and nasal secretions and feces by real-time reverse transcriptase PCR (RT-qPCR) and/or virus isolation...
October 14, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27901503/in-situ-hybridization-and-histopathological-observations-during-ostreid-herpesvirus-1-associated-mortalities-in-pacific-oysters-crassostrea-gigas
#9
Rudolfo Bueno, Matthew Perrott, Magda Dunowska, Cara Brosnahan, Colin Johnston
In a previous longitudinal study conducted during a mortality investigation associated with ostreid herpesvirus-1 (OsHV-1) microvariant in New Zealand Pacific oysters in 2010-2011, temporality of OsHV-1 nucleic acid detection by real-time PCR assay and onset of Pacific oyster mortality was observed. The present study further elucidated the role of OsHV-1 using an in situ hybridization (ISH) assay on sections of Pacific oysters collected from the same longitudinal study. Hybridization of the labelled probe with the target region of the OsHV-1 genome in infected cells was detected colorimetrically using nitro blue tetrazolium (NBT)...
November 22, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/27899805/circulating-tumour-dna-analysis-demonstrates-spatial-mutational-heterogeneity-that-coincides-with-disease-relapse-in-myeloma
#10
S Mithraprabhu, T Khong, M Ramachandran, A Chow, D Klarica, L Mai, S Walsh, D Broemeling, A Marziali, M Wiggin, J Hocking, A Kalff, B Durie, A Spencer
Mutational characterisation in multiple myeloma (MM) currently relies on bone marrow (BM) biopsy, which fails to capture the putative spatial and genetic heterogeneity of this multi-focal disease. Analysis of plasma (PL)-derived circulating free tumour DNA (ctDNA) as an adjunct to BM biopsy, for mutational characterisation and tracking disease progression, was evaluated. Paired BM MM cell DNA and ctDNA from 33 relapsed [RR] and 15 newly diagnosed [ND] patients were analysed for KRAS, NRAS, BRAF and TP53 mutations using the OnTarget™ Mutation Detection (OMD) platform...
November 30, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27889678/early-hippocampal-hyperexcitability-in-ps2app-mice-role-of-mutant-ps2-and-app
#11
Roberto Fontana, Mario Agostini, Emanuele Murana, Mufti Mahmud, Elena Scremin, Maria Rubega, Giovanni Sparacino, Stefano Vassanelli, Cristina Fasolato
Alterations of brain network activity are observable in Alzheimer's disease (AD) together with the occurrence of mild cognitive impairment, before overt pathology. However, in humans as well in AD mouse models, identification of early biomarkers of network dysfunction is still at its beginning. We performed in vivo recordings of local field potential activity in the dentate gyrus of PS2APP mice expressing the human amyloid precursor protein (APP) Swedish mutation and the presenilin-2 (PS2) N141I. From a frequency-domain analysis, we uncovered network hyper-synchronicity as early as 3 months, when intracellular accumulation of amyloid beta was also observable...
November 5, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27889500/enhancing-phosphorus-uptake-efficiency-through-qtl-based-selection-for-root-system-architecture-in-maize
#12
Riliang Gu, Fanjun Chen, Lizhi Long, Hongguang Cai, Zhigang Liu, Jiabo Yang, Lifeng Wang, Huiyong Li, Junhui Li, Wenxin Liu, Guohua Mi, Fusuo Zhang, Lixing Yuan
Root system architecture (RSA) plays an important role in phosphorus (P) acquisition, but enhancing P use efficiency (PUE) in maize via genetic manipulation of RSA has not yet been reported. Here, using a maize recombinant inbred line (RIL) population, we investigated the genetic relationships between PUE and RSA, and developed P-efficient lines by selection of quantitative trait loci (QTLs) that coincide for both traits. In low-P (LP) fields, P uptake efficiency (PupE) was more closely correlated with PUE (r = 0...
November 9, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27887824/reconstructing-a-long-term-record-of-microcystins-from-the-analysis-of-lake-sediments
#13
A Zastepa, Z E Taranu, L E Kimpe, J M Blais, I Gregory-Eaves, R W Zurawell, F R Pick
Based on an analysis of sediment cores from Baptiste Lake (Alberta, Canada), we quantified century-scale trends in cyanobacteria and cyanotoxins, and identified possible drivers of toxigenic cyanobacteria. We measured concentrations of microcystins and pigments preserved in the sediment as proxies of toxigenic cyanobacteria and phytoplankton communities, respectively, while fossil diatom assemblages were used to infer past nutrient concentrations. Microcystins were detected in older sediments (ca. 1800s), pre-dating any significant alteration to the watershed...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27886141/comprehensive-transcriptome-analysis-provides-evidence-of-local-thermal-adaptation-in-three-loaches-genus-misgurnus
#14
Shaokui Yi, Sai Wang, Jia Zhong, Weimin Wang
The geographic distribution of three Misgurnus species, M. anguillicaudatus, M. bipartitus, and M. mohoity, displays a specific pattern in China, coincident with temperature zones. In this study, we sequenced the transcriptomes of these three species and used the sequences to investigate the lineage-specific adaptations within the genus Misgurnus. In total, 51 orphan genes (19 in M. anguillicaudatus, 18 in M. bipartitus, and 14 in M. mohoity) that may contribute to the species-specific adaptations were identified...
November 24, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27881784/low-somatic-sodium-conductance-enhances-action-potential-precision-in-time-coding-auditory-neurons
#15
Yang Yang, Bina Ramamurthy, Andreas Neef, Matthew A Xu-Friedman
: Auditory nerve fibers encode sounds in the precise timing of action potentials (APs), which is used for such computations as sound localization. Timing information is relayed through several cell types in the auditory brainstem that share an unusual property: their APs are not overshooting, suggesting that the cells have very low somatic sodium conductance (gNa). However, it is not clear how gNa influences temporal precision. We addressed this by comparing bushy cells (BCs) in the mouse cochlear nucleus with T-stellate cells (SCs), which do have normal overshooting APs...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27873545/presence-of-lactobacillus-reuteri-in-saliva-coincide-with-higher-salivary-iga-in-young-adults-after-intake-of-probiotic-lozenges
#16
G Braathen, V Ingildsen, S Twetman, D Ericson, M R Jørgensen
The aim of this study was to compare the concentration of salivary immunoglobulin A (IgA) and the selected interleukins (IL)-1β, IL-6, IL-8 and IL-10 in young individuals with presence and non-presence of Lactobacillus reuteri in saliva after a three-week intervention with probiotic lozenges. The study group consisted of 47 healthy individuals aged 18-32 years with no clinical signs of oral inflammation. In a randomised, double-blind, placebo-controlled, cross-over trial participants ingested two lozenges per day containing two strains of the probiotic bacterium L...
November 22, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27872781/two-invasive-thymomas-incidentally-found-during-coronary-artery-bypass-graft-surgery
#17
Navid Omidifar, Maral Mokhtari, Mansoureh Shokripour
Thymoma, the most common neoplasm of the anterior mediastinum, is a rare tumor of thymic epithelium that can be locally invasive. We reported 2 cases of invasive thymoma incidentally found during routine coronary artery bypass graft (CABG) surgery at Faghihee Hospital of Shiraz University of Medical Sciences of Iran in a period of about 6 months. The 2 patients were male and above 60 years old. They had no clinical symptoms and radiological evidence of mediastinal mass before detection of the tumor during operation...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27863206/assessment-of-3-epi-25-hydroxyvitamin-d-levels-during-cholecalciferol-supplementation-in-adults-with-chronic-liver-diseases
#18
Caroline S Stokes, Dietrich A Volmer
Recently, hepatic immaturity was cited as a possible reason for high levels of the C-3 epimer of 25-hydroxyvitamin (25(OH)D) in premature infants: however what role, if any, the liver plays in controlling epimer concentrations is unknown. This study assesses 3-epi-25-hydroxyvitamin D (3-epi-25(OH)D) levels during the course of cholecalciferol supplementation in adults with chronic liver diseases (CLD). Vitamin D metabolites were analyzed in 65 CLD patients with 25(OH)D <30 ng/mL who received 20 000 IU cholecalciferol/week for 6 months...
December 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27862816/rnai-mediated-endogene-silencing-in-strawberry-fruit-detection-of-primary-and-secondary-sirnas-by-deep-sequencing
#19
Katja Härtl, Gregor Kalinowski, Thomas Hoffmann, Anja Preuss, Wilfried Schwab
RNA interference (RNAi) has been exploited as a reverse genetics tool for functional genomics in the non-model species strawberry (Fragaria x ananassa) since 2006. Here, we analyzed for the first time different but overlapping nucleotide sections (> 200 nt) of two endogenous genes, FaCHS (chalcone synthase) and FaOMT (O-methyltransferase), as inducer sequences and a transitive vector system to compare their gene silencing efficiencies. In total, ten vectors were assembled each containing the nucleotide sequence of one fragment in sense and corresponding antisense orientation separated by an intron (inverted hairpin construct, ihp)...
November 18, 2016: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/27862526/systems-genetics-reveals-a-transcriptional-network-associated-with-susceptibility-in-the-maize-gray-leaf-spot-pathosystem
#20
Nanette Christie, Alexander A Myburg, Fourie Joubert, Shane L Murray, Maryke Carstens, Yao-Cheng Lin, Jacqueline Meyer, Bridget G Crampton, Shawn A Christensen, Jean F Ntuli, Sara S Wighard, Yves Van de Peer, Dave K Berger
We used a systems genetics approach to elucidate molecular mechanisms of maize responses to gray leaf spot (GLS) disease, caused by Cercospora zeina, a threat to maize production globally. Expression analysis of earleaf samples in a sub-tropical maize RIL population (CML444 X SC Malawi) subjected in field to C. zeina infection allowed detection of 20,206 expression QTLs (eQTL). Four trans-eQTL hotspots coincided with GLS disease QTLs mapped in the same field experiment. Co-expression network analysis identified three expression modules correlated with GLS disease scores...
November 12, 2016: Plant Journal: for Cell and Molecular Biology
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