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REVIEW
Ailin Zhang, Meiling Zuo, Yuxuan Sun, Jingtao Chen, Liqin Zhu, Wei Liu
Latamoxef is a semi-synthetic, broad-spectrum oxacephem antibiotic used primarily to treat infectious diseases, but the adverse drug reactions, such as the risk of fatal bleeding, once caused physicians to use it less frequently. However, with the rise of antibiotic-resistant bacterial strains, latamoxef is being used again to treat infectious diseases, especially in pediatrics. The pharmacokinetic parameters of latamoxef are highly variable, given the changes in body composition, organ maturation, and development that occurs in pediatrics...
2024: Frontiers in Pediatrics
#22
JOURNAL ARTICLE
Maxim Soucy-Proulx, Hiromi Kato, Sean Coeckelenbergh, Salima Naili Kortaia, Laurence Herboulier, Gabriella Pittau, Patrick Pham, Antoinette Lemoine, Jacques Duranteau, Stéphanie Roullet
BACKGROUND: Liver transplantation (LT) remains a potentially haemorrhagic procedure whose perioperative bleeding and transfusion could be better monitored using point-of-care devices. Quantra® is a device based on sonorheometry to assess whole blood clot formation. Our aims were to describe Quantra® parameters during LT and to study their correlations with standard laboratory parameters, and to determine Quantra® cut-off values for thrombocytopenia, hypofibrinogenemia and coagulation factors' deficit...
January 25, 2024: Journal of Clinical Medicine
#23
JOURNAL ARTICLE
Joana Brioso Infante, Graça Vasconcelos Esteves, João Raposo, João Forjaz de Lacerda
INTRODUCTION: Early death (ED) is the unsolved issue of acute promyelocytic leukemia (APL). The disseminated intravascular coagulation (DIC) score has been proposed as a marker of bleeding and death in APL; whether its temporal evolution predicts outcomes in APL is unknown. We evaluated whether an increasing score 48 h after diagnosis associates with ED. METHODS: Retrospective, single-center study, including patients with newly diagnosed APL between 2000 and 2023, treated with all-transretinoic acid (ATRA) plus anthracycline or arsenic trioxide (ATO)...
February 2, 2024: European Journal of Haematology
#24
JOURNAL ARTICLE
Supapitch Chanthong, Chane Choed-Amphai, Suphara Manowong, Pakinee Tuntivate, Supakanya Tansriratanawong, Krit Makonkawkeyoon, Rungrote Natesirinilkul
OBJECTIVES: This study aimed to determine the test performances of rotational thromboelastometry (ROTEM) and activated partial thromboplastin time-based clot waveform analysis (aPTT-CWA) compared with the International Society on Thrombosis and Hemostasis disseminated intravascular coagulation (ISTH-DIC) score for diagnosis of overt disseminated intravascular coagulation (ODIC) in critically ill children. Prognostic indicators of DIC complications were also evaluated. DESIGN: A prospective cross-sectional observational study was conducted...
February 1, 2024: Pediatric Critical Care Medicine
#25
JOURNAL ARTICLE
Menghan Liu, Xuejie Li, Ronghua Zhou
BACKGROUND: Primary malignant cardiac tumors are rare in clinic, and surgical resection under cardiopulmonary bypass (CPB) remains the main treatment. The non-physiological perfusion process of CPB leads to contact activation, and the resulting coagulopathy and systemic inflammatory response syndrome (SIRS) are common complications. However, it is difficult to predict the impact of foreign tumor fragments on this pathophysiological process once they enter the bloodstream, making this phenomenon more complex and challenging...
January 31, 2024: BMC Anesthesiology
#26
Rushit Zalavadiya, Jugal Hiren Bhatt, Irfan Nagori, Nency Kagathara, Srijana Neupane
Zieve's syndrome, associated with chronic alcoholism, manifests as hemolytic anemia, transient hyperlipidemia, and cholestatic jaundice. Key symptoms comprise nausea, abdominal pain, and jaundice. Diagnosis relies on recognizing the triad in those with an alcohol use history. Supportive management includes blood transfusions and alcohol cessation. The exact pathophysiology remains uncertain, with hypotheses ranging from alcohol-induced liver damage to autoimmune processes. The report emphasizes diagnostic complexities, particularly when concurrent with autoimmune disorders such as latent autoimmune diabetes of adults or complicated by disseminated intravascular coagulation (DIC)...
February 2024: Clinical Case Reports
#27
JOURNAL ARTICLE
Sarah McErlean, John Broughan, Geoff McCombe, Ronan Fawsitt, Mark Ledwidge, Walter Cullen, Joe Gallagher
BACKGROUND: Worldwide, atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults and poses a significant burden to patients, physicians, and healthcare systems. We developed a quality of care score based on the Atrial Fibrillation Better Care pathway recommended by the European Society of Cardiology and the European Heart Rhythm Association guidelines. This is a 14-point score that we have termed the MAGIC score(Management of Atrial Fibrillation in Integrated Care and General Practice)...
January 30, 2024: Family Practice
#28
REVIEW
Felix C F Schmitt, Herbert Schöchl, Kathrin Brün, Sascha Kreuer, Sven Schneider, Stefan Hofer, Christian F Weber
Viscoelastic test (VET) procedures suitable for point-of-care (POC) testing are in widespread clinical use. Due to the expanded range of available devices and in particular due to the development of new test approaches and methods, the authors believe that an update of the current treatment algorithms is necessary. The aim of this article is to provide an overview of the currently available VET devices and the associated reagents. In addition, two treatment algorithms for the VET devices most commonly used in German-speaking countries are presented...
January 23, 2024: Anaesthesiologie
#29
JOURNAL ARTICLE
Luregn J Schlapbach, R Scott Watson, Lauren R Sorce, Andrew C Argent, Kusum Menon, Mark W Hall, Samuel Akech, David J Albers, Elizabeth R Alpern, Fran Balamuth, Melania Bembea, Paolo Biban, Enitan D Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Peter E DeWitt, Idris Evans, Cláudio Flauzino de Oliveira, Christopher M Horvat, David Inwald, Paul Ishimine, Juan Camilo Jaramillo-Bustamante, Michael Levin, Rakesh Lodha, Blake Martin, Simon Nadel, Satoshi Nakagawa, Mark J Peters, Adrienne G Randolph, Suchitra Ranjit, Margaret N Rebull, Seth Russell, Halden F Scott, Daniela Carla de Souza, Pierre Tissieres, Scott L Weiss, Matthew O Wiens, James L Wynn, Niranjan Kissoon, Jerry J Zimmerman, L Nelson Sanchez-Pinto, Tellen D Bennett
IMPORTANCE: Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defined sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection, but it excluded children. OBJECTIVE: To update and evaluate criteria for sepsis and septic shock in children...
January 21, 2024: JAMA
#30
JOURNAL ARTICLE
Transfusion practices in intensive care units: An Australian and New Zealand point prevalence study.
Andrew W J Flint, Karina Brady, Erica M Wood, Le Thi Phuong Thao, Naomi Hammond, Serena Knowles, Conrad Nangla, Michael C Reade, Zoe K McQuilten
OBJECTIVE: To describe current transfusion practices in intensive care units (ICUs) in Australia and New Zealand, compare them against national guidelines, and describe how viscoelastic haemostatic assays (VHAs) are used in guiding transfusion decisions. DESIGN SETTING AND PARTICIPANTS: Prospective, multicentre, binational point-prevalence study. All adult patients admitted to participating ICUs on a single day in 2021. MAIN OUTCOME MEASURES: Transfusion types, amounts, clinical reasons, and triggers; use of anti-platelet medications, anti-coagulation, and VHA...
December 2023: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
#31
A nonneutralizing antibody as cause of prothrombin deficiency in a patient with follicular lymphoma.
Cecilia Augustsson, Knut Taxbro, Karin Strandberg, Eva Zetterberg
Acquired inhibitors of blood coagulation are rare but of clinical importance. Prothrombin is a vitamin K-dependent protein, and acquired antibodies toward prothrombin are often associated with the presence of lupus anticoagulant. We describe a previously healthy 70-year-old man presenting with both hemorrhage and thrombosis as well as a prolonged prothrombin time. At arrival at the hospital, he was diagnosed with deep venous thrombosis, and an enlarged lymph node in the left groin was noted (revealed as follicular lymphoma grade 1 by biopsy)...
January 2024: Clinical Case Reports
#32
JOURNAL ARTICLE
Lina Lin, Mengying Niu, Wei Gao, Chundong Wang, Qiaolin Wu, Fuquan Fang, Yongan Wang, Weijian Wang
BACKGROUND: Shedding of glycocalyx is relevant to worse prognosis in surgical patients, and elevated levels of serum matrix metalloproteinase-9 (MMP-9) are associated with this phenomenon. This study aimed to investigate the dynamic alterations of serum glycocalyx components and MMP-9 during cardiopulmonary bypass (CPB), and evaluate their predictive capacities for prolonged intensive care unit (ICU) stay, as well as their correlation with coagulation dysfunction. METHODS: This retrospective study analyzed serum levels of syndecan-1, heparan sulfate (HS), and MMP-9 at different time points during CPB, and assessed their association with prolonged ICU stay and coagulation dysfunction...
January 15, 2024: Heliyon
#33
JOURNAL ARTICLE
Rosa Toenges, Michael Steiner, Christian Friedrich Weber, Wolfgang Miesbach
INTRODUCTION: Inherited or acquired molecular abnormalities form a clinically heterogeneous group of fibrinogen disorders called dysfibrinogenaemia. Apart from a pediatric case report and in contrast to other clinical conditions, acquired dysfibrinogenaemia has not been previously reported in septic patients. METHODS: In an observational cohort study, 79 adult septic patients were investigated for the presence of acquired dysfibrinogenaemia at the time of their admission to the intensive care unit (ICU) of the University Hospital Frankfurt...
2023: Frontiers in Medicine
#34
JOURNAL ARTICLE
Stan Driessen, Sven M Francque, Stefan D Anker, Manuel Castro Cabezas, Diederick E Grobbee, Maarten E Tushuizen, Adriaan G Holleboom
The prevalence and severity of metabolic dysfunction associated steatotic liver disease (MASLD) are increasing. Physicians who treat patients with MASLD may acknowledge the strong coincidence with cardiometabolic disease including atherosclerotic cardiovascular disease (asCVD). This raises questions on co-occurrence, causality and the need for screening and multidisciplinary care for MASLD in patients with asCVD, and vice versa. Here we review the interrelations of MASLD and heart disease and formulate answers to these matters...
December 25, 2023: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#35
JOURNAL ARTICLE
Jing Liu, Ya-Li Guo, Xiao-Ling Ren
Point-of-care critical ultrasound (POC-CUS) screening plays an increasingly important role in the treatment of critically ill infants. Without POC-CUS, the lives of many infants would not be saved in time and correctly. A premature infant with systemic multiple organ system dysfunction caused by fungal sepsis was treated and nursed under the guidance of POC-CUS monitoring, and the infant was ultimately cured. This premature infant had systemic multiple organ system dysfunction and disseminated intravascular coagulation (DIC) caused by fungal sepsis...
December 8, 2023: Diagnostics
#36
JOURNAL ARTICLE
Tomoe Sato, Mitsutaka Edanaga, Michiaki Yamakage, Ryo Harada, Nobuyoshi Kawaharada
Introduction The point-of-care test (POCT) is useful for blood coagulation management during cardiovascular surgery. Although thromboelastography (TEG6s) has been reported to have targeted benefits for blood transfusion in cardiac surgery, Sonoclot analysis has not yet been fully validated. In this study, we evaluated the accuracy of Sonoclot, especially platelet function (PF) as a platelet concentrate (PC) transfusion parameter, compared to TEG6s in cardiovascular surgery. Methods This single-center, prospective, randomised trial was conducted at a university hospital...
November 2023: Curēus
#37
JOURNAL ARTICLE
Bérénice Tiquet, Franck Pihan, Philippe Thomasset, Michel Denizou, Marius Tifrea, Andreaa Tifrea, Isabelle Orsel, Jean Philippe Marsaud, Jérome Jouan, David Vandroux
OBJECTIVES: In our center, an unusual rate of patients had abnormalities of hemostasis in immediate postoperative period of cardiac surgery. Our objectives were to identify the cause of these sudden hemostasis abnormalities and to evaluate the performances of point of care coagulation testing. METHODS: In this prospective and descriptive study, we included 33 consecutive patients undergoing elective cardiac surgery for 1 month. Heparin-induced anticoagulation and calculation of the protamine dose were tested by the Hemostasis Management System Plus device (Medtronic, Minneapolis, MN, USA)...
February 22, 2023: Perfusion
#38
JOURNAL ARTICLE
Fakhr Al Ayoubi, Malak Al Mashali, Mohamed H Abdallah, Mohamed Al Sheef, Tarek Owaidah
OBJECTIVES: Hospital overload is a persistent occurrence in daily practice. Interventions such as point-of-care testing (POCT) are needed to alleviate the pressure faced by healthcare providers and administrators. METHODS: An invited panel of experts from Saudi Arabia was formed under the auspices of the Saudi Heart Association in order to discuss local treatment gaps in the management of patients receiving anticoagulation therapy. This was done in a series of meetings, which resulted in the development of official recommendations for the implementation of POCT for anticoagulation monitoring in the country...
2023: Journal of the Saudi Heart Association
#39
REVIEW
T P Whitton, W J Healy
Thromboelastography (TEG) is a laboratory assay utilized to evaluate hemostatic properties of blood, identify coagulopathy, and guide blood product administration. While the clinical use of TEG started in the care of surgical patients, the assay has now been incorporated more routinely in the care of the medical patient as well. In this review, we explore the evolution of TEG from the historical perspective of its inception to the current state of the art of the assay. The TEG procedure and its measurements are illustrated along with a table that summarizes recommendations from across the medical and surgical literature...
2023: Ther Adv Pulm Crit Care Med
#40
JOURNAL ARTICLE
Ecaterina Scarlatescu, Paul Y Kim, Sergey P Marchenko, Dana R Tomescu
BACKGROUND: In sepsis, fibrinolysis resistance correlates with worse outcomes. Practically, rotational thromboelastometry (ROTEM) is used to report residual clot amplitude relative to maximum amplitude at specified times after clot formation (clot lysis indices; CLI). However, normal individuals can exhibit similar CLI, thus making it challenging to solely diagnose the low-fibrinolytic state. Furthermore, CLI does not include the kinetics of clot formation, which can affect overall fibrinolysis...
December 15, 2023: Journal of Thrombosis and Haemostasis: JTH
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