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https://www.readbyqxmd.com/read/29165130/determinants-of-polyunsaturated-fatty-acid-concentrations-in-erythrocytes-of-pregnant-japanese-women-from-a-birth-cohort-study-study-protocol-and-baseline-findings-of-an-adjunct-study-of-the-japan-environment-children-s-study
#1
Shoji Saito, Terue Kawabata, Nozomi Tatsuta, Fumiko Kimura, Teruo Miyazawa, Satoshi Mizuno, Hidekazu Nishigori, Takahiro Arima, Yasuo Kagawa, Kouichi Yoshimasu, Kanami Tsuno, Yuki Ito, Michihiro Kamijima, Kunihiko Nakai, Nobuo Yaegashi
BACKGROUND: N-3 polyunsaturated fatty acids (n-3 PUFA) may have multiple beneficial effects on the outcome of pregnancy, maternal health and child development. The present study introduced the protocol of a birth cohort study to examine the beneficial effects of n-3 PUFA status in pregnant Japanese women as an adjunct study of the Japan Environment and Children's Study (JECS). METHODS: The JECS participants in the coastal areas of Miyagi Prefecture were further invited to participate in this adjunct study, and 1,878 pregnant women were enrolled prior to delivery...
April 4, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29162172/cumulative-prenatal-exposure-to-adversity-reveals-associations-with-a-broad-range-of-neurodevelopmental-outcomes-that-are-moderated-by-a-novel-biologically-informed-polygenetic-score-based-on-the-serotonin-transporter-solute-carrier-family-c6-member-4-slc6a4
#2
Patrícia P Silveira, Irina Pokhvisneva, Carine Parent, Shirong Cai, Anu Sathyan Sathyapalan Rema, Birit F P Broekman, Anne Rifkin-Graboi, Michael Pluess, Kieran J O'Donnell, Michael J Meaney
While many studies focus on the association between early life adversity and the later risk for psychopathology, few simultaneously explore diverse forms of environmental adversity. Moreover, those studies that examined the cumulative impact of early life adversity focus uniquely on postnatal influences. The objective of this study was to focus on the fetal period of development to construct and validate a cumulative prenatal adversity score in relation to a wide range of neurodevelopmental outcomes. We also examined the interaction of this adversity score with a biologically informed genetic score based on the serotonin transporter gene...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29162167/effects-of-pre-and-postnatal-maternal-stress-on-infant-temperament-and-autonomic-nervous-system-reactivity-and-regulation-in-a-diverse-low-income-population
#3
Nicole R Bush, Karen Jones-Mason, Michael Coccia, Zoe Caron, Abbey Alkon, Melanie Thomas, Kim Coleman-Phox, Pathik D Wadhwa, Barbara A Laraia, Nancy E Adler, Elissa S Epel
We examined the prospective associations of objective and subjective measures of stress during pregnancy with infant stress reactivity and regulation, an early-life predictor of psychopathology. In a racially and ethnically diverse low-income sample of 151 mother-infant dyads, maternal reports of stressful life events (SLE) and perceived stress (PS) were collected serially over gestation and the early postpartum period. Infant reactivity and regulation at 6 months of age was assessed via maternal report of temperament (negativity, surgency, and regulation) and infant parasympathetic nervous system physiology (respiratory sinus arrhythmia [RSA]) during the Still Face Paradigm...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29157049/small-for-gestational-age-as-an-independent-risk-factor-for-long-term-pediatric-gastrointestinal-morbidity-of-the-offspring
#4
N Steiner, T Wainstock, E Sheiner, I Segal, D Landau, A Walfisch
OBJECTIVE: The concept of neonatal programing has begun to emerge as an important component of adult health. Scarce data exist regarding perinatal risk factors for long-term gastrointestinal (GI) morbidity of the offspring. We aimed to evaluate the association between birthweight (BW) at term and long-term pediatric GI morbidity. STUDY DESIGN: A population-based cohort analysis was performed, comparing the risk of long-term GI morbidity (up to the age of 18 years) in children delivered at term according to their BW...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29155086/systemic-exposure-of-vinpocetine-in-pregnant-sprague-dawley-rats-following-repeated-oral-exposure-an-investigation-of-fetal-transfer
#5
Suramya Waidyanatha, Heather Troy, Natalie South, Seth Gibbs, Esra Mutlu, Brian Burback, Barry S McIntyre, Natasha Catlin
Vinpocetine is being used worldwide by people of all ages, including pregnant women, for its purported multiple health benefits. However, limited data is available addressing the safety/toxicity of vinpocetine. The National Toxicology Program conducted studies to examine potential effects of vinpocetine on the developing rat. Disposition data is helpful to put the fetal findings into context and provide information on the potential risk for humans. The current study reports the systemic exposure and toxicokinetic (TK) parameters of vinpocetine and metabolite, apovincaminic acid (AVA), in pregnant Harlan Sprague Dawley rats, fetuses and amniotic fluid following oral gavage exposure of dams to 5 and 20mg/kg vinpocetine from gestational day 6 to 18...
November 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29154791/associations-of-early-life-urinary-triclosan-concentrations-with-maternal-neonatal-and-child-thyroid-hormone-levels
#6
Joseph M Braun, Aimin Chen, Andrew Hoofnagle, George D Papandonatos, Medina Jackson-Browne, Russ Hauser, Megan E Romano, Margaret R Karagas, Kimberly Yolton, R Thomas Zoeller, Bruce P Lanphear
BACKGROUND: Triclosan, an antimicrobial agent used in some consumer products, reduces endogenous thyroid hormone concentrations in rodents. Despite ubiquitous triclosan exposure and the importance of thyroid hormones for normal fetal development, few human studies have examined the impact of triclosan exposure on maternal, neonatal, or child thyroid hormones. METHODS: In the HOME Study, a prospective cohort from Cincinnati, OH, we measured urinary triclosan concentrations up to three times in pregnant women between 16weeks and delivery, and up to three times in children between age 1-3years...
November 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29151248/adiponectin-and-vitamin-d-binding-protein-are-independently-associated-at-birth-in-both-mothers-and-neonates
#7
Spyridon N Karras, Stergios Α Polyzos, Danforth A Newton, Carol L Wagner, Bruce W Hollis, Jody van den Ouweland, Erdinc Dursun, Duygu Gezen-Ak, Kalliopi Kotsa, Cedric Annweiler, Declan P Naughton
CONTEXT: Adult body fat is associated with birth anthropometry, suggesting a role for metabolic regulators including vitamin D and the adipokines-adiponectin and irisin-which have been reported to interact but, as yet, data remain controversial. OBJECTIVE: To study (i) the relationship between vitamin D, its binding protein (VDBP) and the adipokines, adiponectin, and irisin in mothers and neonates at birth and (ii) their effects on neonate anthropometric outcomes...
November 18, 2017: Endocrine
https://www.readbyqxmd.com/read/29150339/hair-concentration-of-trace-elements-and-growth-in-homeless-children-aged-6years-results-from-the-enfams-study
#8
Lucia Fábelová, Stéphanie Vandentorren, Cécile Vuillermoz, Robert Garnier, Sandrine Lioret, Jérémie Botton
BACKGROUND: Growth is an important indicator of health in early childhood. This is a critical developmental period, during which a number of factors, including exposure to metals, might play a role in later physical and metabolic functions. OBJECTIVE: To study the association between exposure to arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb) and selenium (Se), and physical growth of children from homeless families aged <6years. METHODS: This study was based on data of the cross-sectional survey (ENFAMS), which was conducted by the Observatoire du Samu Social on a random sample of homeless sheltered families in the Paris region during winter 2013...
November 14, 2017: Environment International
https://www.readbyqxmd.com/read/29149678/housing-conditions-and-birth-outcomes-the-national-child-development-study
#9
Emily W Harville, Felicia A Rabito
BACKGROUND: Despite their importance to respiratory and other health outcomes, housing conditions have been little-studied with respect to perinatal outcomes. METHODS: 1927 participants in the British National Child Development Study reported on housing conditions and pregnancy outcomes, including presence/severity of mold/dampness; type of heating; and whether remodeling of various sorts had been conducted. Crowding, based on the number of people in the residence and the number of rooms, was also considered...
November 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/29145339/alveolar-soft-part-sarcoma-with-multiple-brain-and-lung-metastases-in-pregnancy-a-case-report-and-literature-review
#10
Yubo Wang, Jiayue Cui, Xu Yan, Rihua Jin, Xinyu Hong
RATIONAL: Alveolar soft part sarcomas (ASPSs) with multiple brain metastases in pregnancy is a rare entity. PATIENT CONCERNS: We report our experience with a 19-year-old pregnant woman who presented with intermittent headaches and vomiting at 38 weeks gestation. DIAGNOSES: The patient was initially diagnosed as brain metastasis according to computed tomography and magnetic resonance imaging (MRI) imaging. INTERVENTIONS: Cesarean section and craniotomy (complete resection of both brain metastatic lesions) was performed sequentially...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145277/tricho-hepato-enteric-syndrome-with-novel-skiv2l-gene-mutations-a-case-report
#11
Eitaro Hiejima, Takahiro Yasumi, Hiroshi Nakase, Minoru Matsuura, Yusuke Honzawa, Hirokazu Higuchi, Ikuo Okafuji, Tohru Yorifuji, Takayuki Tanaka, Kazushi Izawa, Tomoki Kawai, Ryuta Nishikomori, Toshio Heike
RATIONALE: Tricho-hepato-enteric syndrome (THES) is a rare disorder caused by mutations in the TTC37 or SKIV2L genes and characterized by chronic diarrhea, liver disease, hair abnormalities, and high mortality in early childhood due to severe infection or liver cirrhosis. PATIENT CONCERNS: The patient is the second child of three siblings born to non-consanguineous healthy Japanese parents. She had intrauterine growth retardation and was delivered at 33 weeks of gestation due to placental abruption...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144191/paternal-involvement-and-support-and-risk-of-preterm-birth-findings-from-the-boston-birth-cohort
#12
Pamela J Surkan, Liming Dong, Yuelong Ji, Xiumei Hong, Hongkai Ji, Mary Kimmel, Wan-Yee Tang, Xiaobin Wang
OBJECTIVE: To investigate to what extent paternal involvement and support during pregnancy were associated with preterm (PTB) and small-for-gestational age (SGA) births. METHODS: Using data from the Boston Birth Cohort (n = 7047), multiple logistic regression models were performed to estimate the log odds of either PTB or SGA birth, with paternal involvement, paternal social support, and family and friend social support variables as the primary independent variables...
November 16, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29142783/birth-order-and-maternal-age-for-reported-cases-of-severe-prenatal-cortical-hyperostosis-caffey-silverman-disease
#13
Rolf R Engel, Raul F Cifuentes
The spectrum of prenatal cortical hyperostosis includes a mild phenotype that typically presents after 35 weeks of gestation, and a severe form that presents earlier. The skeletal and systemic manifestations of the severe phenotype remain unexplained. A review of reported cases indicates that older mothers and firstborn infants are overrepresented. This combination suggests decreased fertility. Fourteen years after the birth of the present case, his mother presented with renal failure from multiple myeloma raising the possibility that a maternal antibody may play a role in the etiology of severe prenatal Caffey disease...
July 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29140454/gestational-age-specific-perinatal-mortality-rates-for-assisted-reproductive-technology-art-and-other-births
#14
Abrar A Chughtai, Alex Y Wang, Lisa Hilder, Zhuoyang Li, Kei Lui, Cindy Farquhar, Elizabeth A Sullivan
STUDY QUESTION: Is perinatal mortality rate higher among births born following assisted reproductive technology (ART) compared to non-ART births? SUMMARY ANSWER: Overall perinatal mortality rates in ART births was higher compared to non-ART births, but gestational age-specific perinatal mortality rate of ART births was lower for very preterm and moderate to late preterm births. WHAT IS KNOWN ALREADY: Births born following ART are reported to have higher risk of adverse perinatal outcomes compared to non-ART births...
November 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29137132/maternal-vitamin-d-status-and-the-relationship-with-neonatal-anthropometric-and-childhood-neurodevelopmental-outcomes-results-from-the-seychelles-child-development-nutrition-study
#15
Eamon Laird, Sally W Thurston, Edwin van Wijngaarden, Conrad F Shamlaye, Gary J Myers, Philip W Davidson, Gene E Watson, Emeir M McSorley, Maria S Mulhern, Alison J Yeates, Mary Ward, Helene McNulty, J J Strain
Vitamin D has an important role in early life; however, the optimal vitamin D status during pregnancy is currently unclear. There have been recent calls for pregnant women to maintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yet little is known about the long-term potential benefits or safety of achieving such high maternal 25(OH)D concentrations for infant or child health outcomes. We examined maternal vitamin D status and its associations with infant anthropometric and later childhood neurocognitive outcomes in a mother-child cohort in a sun-rich country near the equator (4...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29135270/-effectiveness-of-prenatal-ultrasound-in-fetal-and-neonatal-malformations-and-examination-of-difficulty-and-uncertainty-factors
#16
Fanni Rebeka Erős, Artúr Beke
INTRODUCTION AND AIM: The birth prevalence of congenital malformations is around 2-3%. The aim of this study was to examine the efficacy of ultrasound diagnostics in detecting congenital malformations. METHOD: We have processed the prenatal sonographic and postnatal clinical details of 1867 inborn abnormalities in 1200 fetuses over a 7-year period. RESULTS: The mean maternal age upon delivery/abortion was 29.96 ± 5.88 years. In 671 cases, the pregnancy concluded in delivery with a mean gestational age of 35...
November 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29132818/bilirubin-albumin-binding-and-unbound-unconjugated-hyperbilirubinemia-in-premature-infants
#17
Sanjiv B Amin, Hongyue Wang
OBJECTIVE: To evaluate the associations between unbound bilirubin (UB) and total serum bilirubin (TSB), bilirubin:albumin molar ratio (BAMR), and bilirubin albumin binding affinity (Ka) as a function of gestational age (GA) in infants born at 24-33 weeks GA. STUDY DESIGN: In a prospective observational study, TSB and UB were measured twice daily at least 8 hours apart during the first postnatal week. Serum albumin was measured to calculate BAMR on each day. The highest UB on each day, corresponding TSB, and serum albumin were used to calculate the Ka on each day...
November 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29132322/stillbirth-is-associated-with-perceived-alterations-in-fetal-activity-findings-from-an-international-case-control-study
#18
Alexander E P Heazell, Jane Warland, Tomasina Stacey, Christin Coomarasamy, Jayne Budd, Edwin A Mitchell, Louise M O'Brien
BACKGROUND: Stillbirth after 28 weeks gestation affects between 1.3-8.8 per 1000 births in high-income countries. The majority of stillbirths in this setting occur in women without established risk factors. Identification of risk factors which could be identified and managed in pregnancy is a priority in stillbirth prevention research. This study aimed to evaluate women's experiences of fetal movements and how these relate to stillbirth. METHODS: An international internet-based case-control study of women who had a stillbirth ≥28 weeks' gestation within 30 days prior to completing the survey (n = 153) and women with an ongoing pregnancy or a live born child (n = 480)...
November 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29131075/the-cerebellar-cerebral-microstructure-is-disrupted-at-multiple-sites-in-very-preterm-infants-with-cerebellar-haemorrhage
#19
Vera Neubauer, Tanja Djurdjevic, Elke Griesmaier, Marlene Biermayr, Elke Ruth Gizewski, Ursula Kiechl-Kohlendorfer
BACKGROUND: Recent advances in magnetic resonance imaging (MRI) techniques have prompted reconsideration of the anatomical correlates of adverse outcomes in preterm infants. The importance of the contribution made by the cerebellum is now increasingly appreciated. The effect of cerebellar haemorrhage (CBH) on the microstructure of the cerebellar-cerebral circuit is largely unexplored. OBJECTIVES: To investigate the effect of CBH on the microstructure of cerebellar-cerebral connections in preterm infants aged <32 gestational weeks...
November 9, 2017: Neonatology
https://www.readbyqxmd.com/read/29130667/-pregnant-outcomes-of-multiparae-in-women-with-advanced-age-%C3%A2-35-years-after-the-2008-wenchuan-earthquake
#20
Jing Fu, Xue-Jiao Li, Hui-Li Zhu, Yong Song, Shi-Yuan Yang, Jing Tan, Guo-Jun Zhou, Wei Huang
OBJECTIVE: To evaluate pregnancy outcomes of multiparae in women with advanced age (≥35 yr.) after the 2008 Wenchuan earthquake. METHODS: Clinical data of 542 pregnant women with prenatal care in Wenchuan during 20082013 were reviewed,comparing preconception conditions,pregnant rates,pregnant complications,and perinatal outcomes between those younger ( n=176) and older ( n=366) than 35 years. RESULTS: In the 542 women,622 conceptions were reported,with 517 deliveries and 522 live births...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
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