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https://www.readbyqxmd.com/read/29792103/prolonged-use-of-antibiotics-after-birth-is-associated-with-increased-morbidity-in-preterm-infants-with-negative-cultures
#1
C Fajardo, B Alshaikh, A Harabor
BACKGROUND: Most preterm infants are exposed to a variable duration of antibiotic therapy after birth despite negative cultures. Data is emerging about the risks of prolonged antibiotics. We sought to assess the association between length of initial antibiotic course and neonatal outcomes in a cohort from a single large perinatal centre. METHODS: Retrospective cohort study of prospectively collected data on all infants with a birth weight of less than 1250 g hospitalized in our NICU in a 4-year window and who had negative blood and CSF cultures in the first 2 days of life...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29790168/periodontitis-and-placental-growth-factor-in-oral-fluids-are-early-pregnancy-predictors-of-gestational-diabetes-mellitus
#2
Alejandra Chaparro, Edgardo Zúñiga, Manuel Varas-Godoy, Daniela Albers, Valeria Ramírez, Marcela Hernández, Juan P Kusanovic, Stephanie Acuña-Gallardo, Gregory Rice, Sebastián E Illanes
BACKGROUND: Gestational Diabetes Mellitus (GDM) affects around 7-10% of all pregnancies. Early detection of predisposition to GDM is the first step in developing efficacious preventive treatment. The objective of the present study was to establish the utility of placental proteins presents in oral fluids (gingival crevicular fluid [GCF] and saliva), and periodontal disease status as early pregnancy predictors of GDM. MATERIAL AND METHODS: A nested case control within a prospective cohort was conducted...
May 22, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29790070/genotyping-single-sperm-cells-by-universal-marsala-enables-the-acquisition-of-linkage-information-for-combined-pre-implantation-genetic-diagnosis-and-genome-screening
#3
Haitao Wu, Xiaoting Shen, Lei Huang, Yanhong Zeng, Yumei Gao, Lin Shao, Baomin Lu, Yiping Zhong, Benyu Miao, Yanwen Xu, Yali Wang, Yubin Li, Luoxing Xiong, Sijia Lu, X Sunney Xie, Canquan Zhou
PURPOSE: This paper aims to investigate the feasibility of performing pre-implantation genetic diagnosis (PGD) and pre-implantation genetic screening (PGS) simultaneously by a universal strategy without the requirement of genotyping relevant affected family members or lengthy preliminary work on linkage analysis. METHODS: By utilizing a universal Mutated Allele Revealed by Sequencing with Aneuploidy and Linkage Analyses (MARSALA) strategy based on low depth whole genome sequencing (~3x), not involving specific primers' design nor the enrichment of SNP markers for haplotype construction...
May 22, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29789947/relationship-between-brain-function-aeeg-and-brain-structure-mri-and-their-predictive-value-for-neurodevelopmental-outcome-of-preterm-infants
#4
Britta Hüning, Tobias Storbeck, Nora Bruns, Frauke Dransfeld, Julia Hobrecht, Julia Karpienski, Selma Sirin, Bernd Schweiger, Christel Weiss, Ursula Felderhoff-Müser, Hanna Müller
To improve the prediction of neurodevelopmental outcome in very preterm infants, this study used the combination of amplitude-integrated electroencephalography (aEEG) within the first 72 h of life and cranial magnetic resonance imaging (MRI) at term equivalent age. A single-center cohort of 38 infants born before 32 weeks of gestation was subjected to both investigations. Structural measurements were performed on MRI. Multiple regression analysis was used to identify independent factors including functional and structural brain measurements associated with outcome at a corrected age of 24 months...
May 22, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29787984/polybrominated-diphenyl-ether-pbde-exposures-and-thyroid-hormones-in-children-at-age-3-years
#5
Ann M Vuong, Joseph M Braun, Glenys M Webster, R Thomas Zoeller, Andrew N Hoofnagle, Andreas Sjödin, Kimberly Yolton, Bruce P Lanphear, Aimin Chen
BACKGROUND: Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood. METHODS: We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003-2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16 ± 3 weeks gestation and in child serum at 1-3 years...
May 19, 2018: Environment International
https://www.readbyqxmd.com/read/29783717/associations-of-maternal-vitamin-d-deficiency-with-pregnancy-and-neonatal-complications-in-developing-countries-a-systematic-review
#6
REVIEW
Paige van der Pligt, Jane Willcox, Ewa A Szymlek-Gay, Emily Murray, Anthony Worsley, Robin M Daly
Pregnant women in Asia, the Middle East, Africa and Latin America are at risk of vitamin D deficiency (VDD) and prevalence throughout these regions are among the highest, globally. Maternal VDD has been associated with increased risk of a number of adverse maternal and neonatal health outcomes, yet research from developing countries is limited. We assessed the associations of maternal VDD during pregnancy with adverse health outcomes by synthesizing the literature from observational studies conducted in developing countries...
May 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29782439/the-positive-association-between-duration-of-skin-to-skin-contact-and-blood-glucose-level-in-full-term-infants
#7
Yuki Takahashi, Koji Tamakoshi
The aim of this study was to evaluate the contribution of the duration of skin-to-skin contact (SSC) on blood glucose levels at 2 hours after birth in healthy full-term infants. This observational study was done at one of the baby-friendly hospitals located in Aichi, Japan in 2009. Sixty newborn infants who were born vaginally from uncomplicated pregnancies were participated. All infants were held SSC within 5 minutes. All data regarding neonatal information, blood glucose levels at 2 hours of age, and maternal information were obtained from their medical history...
May 17, 2018: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/29781571/new-approach-to-accurate-interpretation-of-sickle-cell-disease-newborn-screening-by-applying-multiple-of-median-cutoffs-and-ratios
#8
Bichr Allaf, Franck Patin, Jacques Elion, Nathalie Couque
BACKGROUND: The main goal of newborn screening (NBS) for sickle cell disease (SCD) is to detect affected neonates so that specific preventive care can be implemented. High-performance liquid chromatography (HPLC) used for NBS has high sensitivity and specificity, but we lack guidelines for quantitative hemoglobin (Hb) fraction interpretation. The purpose of this study was to determine cutoff values to standardize quantitative interpretation in SCD NBS for different clinical situation such as, red blood cell transfusion or beta-thalassemia, which can be real screening pitfalls...
May 21, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29781074/identifying-risk-factors-for-cesarean-scar-pregnancy-a-retrospective-study-of-79-cases
#9
Min Shi, Hui Zhang, Sha-Sha Qi, Wen-Hui Liu, Ming Liu, Xing-Bo Zhao, Yu-Lan Mu
OBJECTIVES: To explore the possible risk factors for cesarean scar pregnancy (CSP), the incidence of which is increasing rapidly in China. MATERIAL AND METHODS: 79 patients with CSP and 69 non-CSP expectant mothers with at least 1 previous cesarean section were employed in the study. The obstetric histories of the participants were collected and analyzed using Chi square test. RESULTS: We found that 77.2% CSP patients had ≥ 3 pregnancies and only 36...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29780772/the-trends-and-risk-factors-to-predict-adverse-outcomes-in-gestational-diabetes-mellitus-a-10-year-experience-from-2006-to-2015-in-a-single-tertiary-center
#10
Minji Kim, Juyoung Park, Soo Hyun Kim, Yoo Min Kim, Cheonga Yee, Suk-Joo Choi, Soo-Young Oh, Cheong-Rae Roh
Objective: To investigate the change of maternal characteristics, delivery and neonatal outcomes in gestational diabetes mellitus (GDM) over recent 10 years and to identify the risk factors associated with adverse outcome. Methods: Consecutive GDM patients (n=947) delivered in our institution were included. Research period was arbitrarily divided into 2 periods (period 1: from 2006 to 2010, period 2: from 2011 to 2015). Multiple pregnancies or preexisting diabetes were excluded...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29780352/the-nomogram-of-penile-length-and-circumference-in-iranian-term-and-preterm-neonates
#11
Fahimeh Soheilipour, Farzaneh Rohani, Elham Hashemi Dehkordi, Roya Isa Tafreshi, Parisa Mohagheghi, Seyed-Mohammadsalar Zaheriani, Fatemeh Jesmi, Hamid Salehiniya
Background and objectives: The normal length of penis in preterm and term neonates is different among different nations, and is affected by various factors. The present study aimed to determine stretched penile length (SPL) values and cutoff level of micropenis in term and preterm Iranian neonates, for the first time. Materials and methods: All male neonates born in two general hospitals of Tehran (Akbarabadi, and Rasoul hospitals), center of Iran, with gestational age of 28-42 weeks were included and their SPL and penile circumference (PC) were examined on the first 3 days after birth by the same physician...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29780028/induced-endometrial-trauma-endometrial-scratch-in-the-mid-luteal-menstrual-cycle-phase-preceding-first-cycle-ivf-icsi-versus-usual-ivf-icsi-therapy-study-protocol-for-a-randomised-controlled-trial
#12
Clare Pye, Robin Chatters, Judith Cohen, Kate Brian, Ying C Cheong, Susan Laird, Lamiya Mohiyiddeen, Jonathan Skull, Stephen Walters, Tracey Young, Mostafa Metwally
INTRODUCTION: Endometrial trauma commonly known as endometrial scratch (ES) has been shown to improve pregnancy rates in women with a history of repeated implantation failure undergoing in vitro fertilisation (IVF), with or without intracytoplasmic sperm injection (ICSI). However, the procedure has not yet been fully explored in women having IVF/ICSI for the first time. This study aims to examine the effect of performing an ES in the mid-luteal phase prior to a first-time IVF/ICSI cycle on the chances of achieving a clinical pregnancy and live birth...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29779414/the-effect-of-intrauterine-growth-on-leukocyte-telomere-length-at-birth
#13
Alketa Stefa, Agaristi Lamprokostopoulou, Despina D Briana, Anna Kontogeorgou, Ifigeneia Papageorgiou, Ariadne Malamitsi-Puchner, Ourania Tsitsilonis, Sarantis Gagos, Evangelia Charmandari
OBJECTIVE: Telomeres are specialized nucleoprotein structures located at the ends of chromosomes, which play a crucial role in genomic stability. Telomere shortening has been proposed as a biomarker for the onset of age-related diseases. This study aimed to determine whether restricted or increased intrauterine growth affects leukocyte telomere length (LTL) at birth. MATERIAL AND METHODS: One hundred sixty five (n = 165) full-term neonates participated in the study...
May 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29777280/primary-draining-vein-stenting-for-obstructive-total-anomalous-pulmonary-venous-connection-in-neonates-with-right-atrial-isomerism-and-functional-single-ventricle-improves-outcome
#14
Masataka Kitano, Takaya Hoashi, Takashi Kakuta, Kazuto Fujimoto, Akira Miyake, Ken-Ichi Kurosaki, Hazime Ichikawa, Isao Shiraishi
For neonates with right atrial isomerism (RAI), functional single ventricle (f-SV), and obstructive total anomalous pulmonary venous connection (TAPVC), primary TAPVC repair (TAPVCR) has a poor outcome. At our hospital, the survival rate at 1 year of such neonates undergoing primary TAPVCR between 1999 and 2010 (TAPVCR group) was 30% (3/10). Most deceased cases suffered from capillary leak syndrome and unstable pulmonary resistance after the surgeries. We sought to determine whether less invasive primary draining vein stenting (DVS) improved the outcome of these neonates...
May 18, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29777227/in-utero-exposure-to-gestational-diabetes-and-adiposity-does-breastfeeding-make-a-difference
#15
L L Hui, A M Li, E A S Nelson, G M Leung, S L Lee, C M Schooling
BACKGROUND/OBJECTIVES: Short-term breastfeeding from mothers with gestational diabetes (GDM) may programme metabolism and increase offspring diabetes risk. We examined the association of in utero GDM exposure with adiposity from infancy to adolescence, and whether any association was modified by breastfeeding during early infancy. METHODS: In the prospective Chinese birth cohort "Children of 1997" (n = 7342, 88% follow-up rate), generalised estimate equations with multiple imputation were used to assess associations of in utero GDM exposure with age- and sex-specific body mass index (BMI) z-score during infancy (3 and 9 months), childhood (2- < 8 years) and adolescence (8-16 years), adjusted for sex, parity, maternal age, birth place, preeclampisa, smoking, and family socio-economic position...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29776004/knowledge-and-health-beliefs-about-gestational-diabetes-and-healthy-pregnancy-s-breastfeeding-intention
#16
Seungmi Park, Jung Lim Lee, Jang In Sun, Youngji Kim
AIMS AND OBJECTIVES: If the knowledge and health beliefs relating to gestational diabetes mellitus (GDM) during pregnancy are associated with behaviours during pregnancy and lactation, this suggests potential educational interventions. BACKGROUNDS: Women with GDM are more likely to develop type 2 diabetes mellitus (T2DM), and babies with GDM incur increased risk of neonatal hypoglycaemia and childhood obesity. Breastfeeding is an effective way to improve maternal and lipid metabolism of gestational diabetes mothers, and to lower the risk of T2DM after birth, to prevent conception...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29775434/births-final-data-for-2016
#17
Joyce A Martin, Brady E Hamilton, Michelle J K Osterman, Anne K Driscoll, Patrick Drake
This report presents 2016 data on U.S. births according to a wide variety of characteristics. Trends in fertility patterns and maternal and infant characteristics are described and interpreted.Descriptive tabulations of data reported on the birth certificates of the 3.95 million births that occurred in 2016 are presented. Data are presented for maternal age, live-birth order, race and Hispanic origin, marital status, tobacco use, prenatal care, source of payment for the delivery, method of delivery, gestational age, birthweight, and plurality...
January 2018: National Vital Statistics Reports
https://www.readbyqxmd.com/read/29772579/antenatal-workup-of-early-megacystis-and-selection-of-candidates-for-fetal-therapy
#18
Federica Fontanella, Leonie Duin, Phebe N Adama van Scheltema, Titia E Cohen-Overbeek, Eva Pajkrt, Mireille Bekker, Christine Willekes, Caroline J Bax, Dick Oepkes, Catia M Bilardo
OBJECTIVE: To investigate the best criteria for discriminating fetuses with isolated posterior urethral valves from those theoretically not eligible for fetal treatment because of complex megacystis, high chance of spontaneous resolution, and urethral atresia. METHODS: A retrospective national study was conducted in fetuses with megacystis detected before 17 weeks' gestation (early megacystis). RESULTS: In total, 142 cases with fetal megacystis were included in the study: 52 with lower urinary tract obstruction, 29 with normal micturition at birth, and 61 with miscellaneous syndromal associations, chromosomal and multiple structural abnormalities (complex megacystis)...
May 17, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29770901/factors-impacting-unbound-vancomycin-concentrations-in-neonates-and-young-infants
#19
Anne Smits, Steven Pauwels, Matthijs Oyaert, Nele Peersman, Isabel Spriet, Veroniek Saegeman, Karel Allegaert
Vancomycin pharmacokinetic (PK) and pharmacodynamic (PD) data in neonates are based on total concentrations. However, only unbound vancomycin is pharmacologically active. The objective was to determine vancomycin protein binding and the covariates impacting unbound vancomycin concentration in neonates and young infants. In neonates and young infants to whom vancomycin was administered intermittently for medical indications, total and unbound vancomycin plasma concentrations were determined using LC-MS/MS. Sampling occurred randomly during vancomycin exposure, covering a broad range of concentrations...
May 16, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29769646/long-term-impacts-of-prenatal-synthetic-glucocorticoids-exposure-on-functional-brain-correlates-of-cognitive-monitoring-in-adolescence
#20
Liesa Ilg, Manousos Klados, Nina Alexander, Clemens Kirschbaum, Shu-Chen Li
The fetus is highly responsive to the level of glucocorticoids in the gestational environment. Perturbing glucocorticoids during fetal development could yield long-term consequences. Extending prior research about effects of prenatally exposed synthetic glucocorticoids (sGC) on brain structural development during childhood, we investigated functional brain correlates of cognitive conflict monitoring in term-born adolescents, who were prenatally exposed to sGC. Relative to the comparison group, behavioral response consistency (indexed by lower reaction time variability) and a brain correlate of conflict monitoring (the N2 event-related potential) were reduced in the sGC exposed group...
May 16, 2018: Scientific Reports
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