Nicolas A Fraunhoffer, Analia M Abuelafia, Carlos Teyssedou, Eduardo Chuluyan, Martin Bigonnet, Laurent Palazzo, Odile Gayet, Remy Nicolle, Jerome Cros, Juan Iovanna, Nelson Dusetti
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a survival rate of less than 7%, mainly due to the hepatic metastatic spread. Despite the importance of understanding PDAC metastases, central questions remain concerning their biology and chemosensitivity. Moreover, the transcriptomic divergence between primary tumor (PT) and hepatic metastases (HM) has been poorly studied and without a clear dissection of the confounding tumoral-surrounding tissue. METHODS: Here, to unravel key biological features not biased by the surrounding tissue, we implemented a blind source separation based on independent component analysis, ProDenICA, on a treatment-naïve cohort of PDAC paired samples and a cohort of 305 resectable patients...
August 1, 2021: European Journal of Cancer