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https://www.readbyqxmd.com/read/29222936/role-of-central-oxytocin-and-dopamine-systems-in-nociception-and-their-possible-interactions-suggested-hypotheses
#1
Mohammed Gamal-Eltrabily, Alfredo Manzano-García
Central oxytocin and dopamine have an important role in the process of nociception at the spinal level as well as supraspinal structures, e.g. anterior cingulate cortex, insular cortex, amygdala, nucleus accumbens, and hypothalamus. Many studies have pointed out the importance of both systems in the pain descending modulatory system and in pain-related symptoms in some chronic disorders, e.g. Parkinson disease and fibromyalgia. The interaction between oxytocin and dopamine systems has been addressed in some motivational behaviors, e...
December 9, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29222926/depressive-personality-vulnerability-in-chronic-physical-pain-centrality-of-sociotropy
#2
Golan Shahar, Sheera F Lerman, Maayan Topaz, Silviu Brill, Hadar Shalev, Zvia Rudich
BACKGROUND: Chronic physical pain is one of modern medicine's principal challenges. Recently, there has been a keen research interest in the role of Depressive Personality Vulnerability (DPV) in the course of chronic pain. OBJECTIVE: This is the first attempt to examine the role of three leading DPV dimensions - sociotropy, autonomy, and self-criticism - in chronic pain. METHOD: Chronic pain patients (N = 428) were assessed four times as to their pain, disability, anxious-depression, and pain-based catastrophizing...
December 9, 2017: Journal of Personality
https://www.readbyqxmd.com/read/29222851/convergent-validity-of-the-dutch-central-sensitization-inventory-associations-with-psychophysical-pain-measures-quality-of-life-disability-and-pain-cognitions-in-patients-with-chronic-spinal-pain
#3
Jeroen Kregel, Charline Schumacher, Mieke Dolphens, Anneleen Malfliet, Dorien Goubert, Dorine Lenoir, Barbara Cagnie, Mira Meeus, I Coppieters
OBJECTIVE: Symptoms of Central Sensitization (CS) have been described in patients with chronic spinal pain (CSP). Although a gold standard to diagnose CS is lacking, psychophysical pain measures are often used. The Central Sensitization Inventory (CSI) is proposed as an alternative method and indirect tool for evaluation of CS symptomatology. The aim of the current study was to evaluate the convergent validity of the CSI by investigating the association with psychophysical pain measures and self-reported measures of current pain intensity, quality of life, disability, and catastrophizing in CSP patients...
December 8, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29222203/type-and-frequency-of-side-effects-during-pc6-acupuncture-observations-from-therapists-and-patients-participating-in-clinical-efficacy-trials-of-acupuncture
#4
Anna Enblom, Anna Johnsson
BACKGROUND: Many therapists practise PC6 acupuncture for emesis (nausea and vomiting) during pregnancy, different cancer therapies, palliative care, after surgery, or to induce relaxing effects in general. Knowledge of side effects is central to shared decision-making. AIM: To describe the type and frequency of side effects and the level of needle-induced pain during PC6 acupuncture. METHODS: We included 1298 PC6 acupuncture treatments, delivered to 221 participants (77% women, mean age 52...
December 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29221427/validity-of-the-dutch-modified-paindetect-questionnaire-for-patients-with-hip-or-knee-osteoarthritis
#5
Wietske Rienstra, Tim Blikman, Baukje Dijkstra, Jos van Raay, Geranda Slager, Sjoerd Bulstra, Martin Stevens, Inge van den Akker-Scheek
BACKGROUND: The modified painDETECT questionnaire (PDQ) is a self-reported questionnaire to discriminate between nociceptive and neuropathic-like pain in patients with knee/hip osteoarthritis (OA). This study aims to assess the structural and construct validity of this questionnaire. METHODS: Confirmatory factor analysis and hypothesis-testing was used. For 168 patients, predefined hypotheses were formulated on the correlation between the modified painDETECT and several other questionnaires, and in a subsample of 46 with pain pressure thresholds (PPTs)...
December 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29220541/yoga-for-stroke-rehabilitation
#6
REVIEW
Maggie Lawrence, Francisco T Celestino Junior, Hemilianna Hs Matozinho, Lindsay Govan, Jo Booth, Jane Beecher
BACKGROUND: Stroke is a major health issue and cause of long-term disability and has a major emotional and socioeconomic impact. There is a need to explore options for long-term sustainable interventions that support stroke survivors to engage in meaningful activities to address life challenges after stroke. Rehabilitation focuses on recovery of function and cognition to the maximum level achievable, and may include a wide range of complementary strategies including yoga.Yoga is a mind-body practice that originated in India, and which has become increasingly widespread in the Western world...
December 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29220355/adults-with-patellofemoral-pain-do-not-exhibit-manifestations-of-peripheral-and-central-sensitization-when-compared-to-healthy-pain-free-age-and-sex-matched-controls-an-assessor-blinded-cross-sectional-study
#7
Michael Skovdal Rathleff, Camilla Rams Rathleff, Aoife Stephenson, Rebecca Mellor, Mark Matthews, Kay Crossley, Bill Vicenzino
Patellofemoral Pain (PFP) is highly prevalent among adults and adolescents. Localized mechanical hyperalgesia around the knee and tibialis anterior have been observed in people with PFP, but limited knowledge of potential manifestations of central sensitisation exists. The aims of this study were to study conditioned pain modulation (CPM) and wide-spread hyperalgesia in adults with PFP. This assessor-blinded cross-sectional study design compared CPM and mechanical pressure pain thresholds (PPT) between 33 adults (23 females) diagnosed with PFP and 32 age and sex matched pain-free controls...
2017: PloS One
https://www.readbyqxmd.com/read/29220110/non-responsiveness-and-susceptibility-of-opioids-side-effects-related-to-cancer-patients-clinical-characteristics-a-post-hoc-analysis
#8
Oscar Corli, Anna Roberto, Michael I Bennett, Francesca Galli, Nicole Corsi, Eliana Rulli, Raffaella Antonione
BACKGROUND: Response to opioids is not always positive in cancer patients. A considerable proportion of patients do not respond (non-responders, NRs) or experience severe toxicity. The aim of this analysis was to assess the role of demographic characteristics, pain features, comorbidities and ongoing therapy on the lack of efficacy and on the occurrence of severe adverse drug reactions (ADRs). METHODS: This is a post-hoc analysis of a randomized controlled trial that involved 520 patients and was aimed to evaluate the efficacy and safety of four strong opioids...
December 8, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29219169/pharmacokinetics-and-pharmacodynamics-of-sublingual-sufentanil-for-postoperative-pain-management
#9
REVIEW
T van de Donk, S Ward, R Langford, A Dahan
Achieving successful treatment of postoperative pain remains a challenge. Recently, a sufentanil sublingual tablet system has been developed for treatment of moderate-to-severe postoperative pain. The phenylpiperidine sufentanil is a potent analgesic that rapidly crosses the blood-brain barrier and selectively activates central μ-opioid receptors. The system makes use of a hand-held dispenser system, which contains forty 15-μg sufentanil sublingual micro-tablets. The patient can release one tablet at 20-min intervals using a unique radiofrequency adhesive tag, which is wrapped around the patient's thumb...
December 8, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29217360/sonographic-findings-of-painful-hemiplegic-shoulder-after-stroke
#10
Pei-Hsin Lin
BACKGROUND: Hemiplegic shoulder pain is common in stroke patients and can influence rehabilitation outcome. The underlying pathology can be various: in addition to impaired motor control and altered peripheral and central nervous activity, soft tissue lesions may also play an important role. It remains unclear how these pathologies may interact or correlate with each other. METHODS: This retrospective study collected data from 26 stroke patients who received sonography examination due to shoulder pain...
December 4, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29217162/association-of-inflammatory-mediators-with-pain-perception
#11
REVIEW
S Ronchetti, G Migliorati, D V Delfino
Treatment of pain has always been a major goal in the clinic, as it is related to several pathological conditions of inflammatory origin and surgical procedures, which are associated with inflammatory mediators. Understanding the molecular mechanisms underlying the association between inflammatory mediators and pain perception, from peripheral to central sensitization, can provide the basis for the development of new pharmacological treatments. Despite safety concerns, till date, the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to be efficacious, safe, and well tolerated by patients...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29216913/food-borne-illness-amongst-health-care-workers-at-a-central-hospital-harare-zimbabwe-2016-a-retrospective-cohort-study
#12
Zvanaka Sithole, Tsitsi Juru, Prosper Chonzi, Donewell Bangure, Gerald Shambira, Notion Tafara Gombe, Mufuta Tshimanga
OBJECTIVES: Health care workers (HCW) at a Central Hospital, were served lunch at the hospital canteen on 12 December 2016. On 12 December 2016 at 1700 h, there was a sudden onset of symptoms suggestive of gastrointestinal illness among HCW. We conducted a retrospective cohort study to determine the cause and the factors associated with illness among the HCW at the hospital. RESULTS: We interviewed 96 respondents. The median incubation period was 6 h (Q1 = 4; Q3 = 12)...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29216211/validation-of-the-japanese-version-of-the-central-sensitization-inventory-in-patients-with-musculoskeletal-disorders
#13
Katsuyoshi Tanaka, Tomohiko Nishigami, Akira Mibu, Masahiro Manfuku, Satoko Yono, Yoshikazu Shinohara, Akihito Tanabe, Rei Ono
BACKGROUND: Many musculoskeletal pain conditions are characterized by hypersensitivity, which is induced by central sensitization (CS). A questionnaire, the Central Sensitization Inventory (CSI), was recently developed to help clinicians identify patients whose presenting symptoms may be related to central sensitivity syndrome (CSS). The aims of the present study were to examine criterion validity and construct validity of the Japanese version of the CSI (CSI-J), and to investigate prevalence rates of CS severity levels in patients with musculoskeletal disorders...
2017: PloS One
https://www.readbyqxmd.com/read/29214166/mirnas-important-targets-for-oral-cancer-pain-research
#14
REVIEW
Cláudia Maria Pereira, Dayany Sehnem, Estevão Oliveira da Fonseca, Heráclito Fernando Gurgel Barboza, Antônio Carlos Pires de Carvalho, Alexandre F M DaSilva, Vivaldo Moura-Neto, Marcos F DosSantos
Pain is a symptom shared by an incredible number of diseases. It is also one of the primary conditions that prompt individuals to seek medical treatment. Head and neck squamous cell carcinoma (HNSCC) corresponds to a heterogeneous disease that may arise from many distinct structures of a large, highly complex, and intricate region. HNSCC affects a great number of patients worldwide and is directly associated with chronic pain, which is especially prominent during the advanced stages of oral squamous cell carcinoma (OSCC), an anatomical and clinical subtype that corresponds to the great majority oral cancers...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29213230/pannexin-1-modulates-axonal-growth-in-mouse-peripheral-nerves
#15
Steven M Horton, Carlos Luna Lopez, Elisabeth Blevins, Holly Howarth, Jake Weisberg, Valery I Shestopalov, Helen P Makarenkova, Sameer B Shah
The pannexin family of channels consists of three members-pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments. Pannexin-mediated release of intracellular ATP into the extracellular space has been tied to a number of cellular activities, primarily through the activity of type P2 purinergic receptors. Previous work indicates that the opening of Panx1 channels and activation of purinergic receptors by extracellular ATP may cause inflammation and apoptosis...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29212177/differences-in-brain-gray-matter-volume-in-patients-with-crohn-s-disease-with-and-without-abdominal-pain
#16
Chunhui Bao, Peng Liu, Yin Shi, Luyi Wu, Xiaoming Jin, Xiaoqing Zeng, Jianye Zhang, Di Wang, Huirong Liu, Huangan Wu
Increasing evidence indicates that abnormal pain processing is present in the central nervous system of patients with Crohn's disease (CD). The purposes of this study were to assess changes in gray matter (GM) volumes in CD patients in remission and to correlate structural changes in the brain with abdominal pain. We used a 3.0 T magnetic resonance scanner to examine the GM structures in 21 CD patients with abdominal pain, 26 CD patients without abdominal pain, and 30 healthy control subjects (HCs). Voxel-based morphometric analyses were used to assess the brain GM volumes...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211026/a-review-of-chronic-pain-and-cognitive-mood-and-motor-dysfunction-following-mild-traumatic-brain-injury-complex-comorbid-and-or-overlapping-conditions
#17
REVIEW
Ramesh Grandhi, Samon Tavakoli, Catherine Ortega, Maureen J Simmonds
Mild traumatic brain injury (mTBI) is commonly encountered in clinical practice. While the cognitive ramifications of mTBI are frequently described in the literature, the impact of mTBI on emotional, sensory, and motor function is not as commonly discussed. Chronic pain is a phenomenon more prevalent among patients with mTBI compared to those with moderate or severe traumatic brain injury. Chronic pain can become a primary disorder of the central nervous system (CNS) expressed as widespread pain, and cognitive, mood, and movement dysfunction...
December 6, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29210306/synergistic-antinociceptive-activity-of-combined-aqueous-extracts-of-artemisia-campestris-and-artemisia-herba-alba-in-several-acute-pain-models
#18
Imededdine Kadi, Mohamed Ouinten, Nadhir Gourine, Mohamed Yousfi
In this study, total phenolic and flavonoid contents, acute toxicity and the antinociceptive activity of Artemisia campestris and Artemisia herba-alba, individually and in combination, were investigated using multiple forms of pain in animals. Our results have been shown that plants are relatively safe without clinical signs of toxicity in animals. Thus, extracts were presented high levels in phenolic and flavonoid contents. Artemisia decoctions with 100, 200, 400 mg/kg b-w studied dose, clearly attenuate chemical and thermal noxious stimuli in writhing, formalin and hot-plate tests, and significantly reduced paw oedema in formalin test...
December 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29209204/reward-circuitry-plasticity-in-pain-perception-and-modulation
#19
REVIEW
Marcos F DosSantos, Brenda de Souza Moura, Alexandre F DaSilva
Although pain is a widely known phenomenon and an important clinical symptom that occurs in numerous diseases, its mechanisms are still barely understood. Owing to the scarce information concerning its pathophysiology, particularly what is involved in the transition from an acute state to a chronic condition, pain treatment is frequently unsatisfactory, therefore contributing to the amplification of the chronic pain burden. In fact, pain is an extremely complex experience that demands the recruitment of an intricate set of central nervous system components...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29209138/effects-of-glutathione-on-mechanical-allodynia-and-central-sensitization-in-chronic-postischemic-pain-rats
#20
Jinseok Yeo, Hoon Jung, Hyerim Lee
Background: The chronic postischemia pain (CPIP) model is an animal model using ischemia/reperfusion injury that mimics the symptoms of complex regional pain syndrome type I. Glutathione (GSH) prevents ischemia/reperfusion injury by scavenging free radicals. We conducted this study to investigate the protective effect of GSH in CPIP rats via changes of mechanical allodynia and phospholyration of the N-methyl-D-aspartate receptor subunit GluN1. Methods: We divided 45 rats into 5 groups: sham, CPIP, CPIP + GSH 100 mg/kg, CPIP + GSH 200 mg/kg, and CPIP + GSH 500 mg/kg...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
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