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JOURNAL ARTICLE
Amela Selimović, Nina Mekić, Selma Terzić, Almira Ćosićkić, Evlijana Zulić, Majda Mehmedović
Functional gastrointestinal disorders in childhood (FGIDs) constitute a significant time-consuming clinical problem for healthcare practitioners, and they carry an important psychosocial burden for patients and their families. The aim of this study was to characterize etiology, clinical features, and interventions in a paediatric cohort of patients with FGIDs, who were referred to a tertiary care university-affiliated centre. Methods A retrospective study of children aged 1-15 years old referred to the Clinic for Children's Diseases, University Clinical Center Tuzla, from January 2022 to December 2022, who fulfilled criteria for FGIDs (n=209), were divided in three groups: 0-3, 4-10 and 11-15 years old...
February 1, 2024: Medicinski Glasnik
#22
RANDOMIZED CONTROLLED TRIAL
Engy S Elkaragy, Mohammed M Shamseya, Rasha H Metwally, Eman R Mansour, Sameh A Lashen
OBJECTIVES: Adolescent and pediatric functional constipation (FC) is a common clinical problem. Currently, data on lubiprostone for the treatment of pediatric FC are scarce. This study investigated the efficacy and safety of lubiprostone in the treatment of pediatric FC. METHODS: In a single-blinded, randomized controlled study, we included 280 patients aged 8-18 years with FC. Patients were randomized either to a weight-based lubiprostone dose (n = 140) or conventional laxatives (n = 140), including lactulose, bisacodyl, or sodium picosulfate, for 12 weeks, followed by 4 weeks posttreatment follow-up...
April 2024: Journal of Pediatric Gastroenterology and Nutrition
#23
JOURNAL ARTICLE
Ekaterina Pazukhina, Mikhail Rumyantsev, Dina Baimukhambetova, Elena Bondarenko, Nadezhda Markina, Yasmin El-Taravi, Polina Petrova, Anastasia Ezhova, Margarita Andreeva, Ekaterina Iakovleva, Polina Bobkova, Maria Pikuza, Anastasia Trefilova, Elina Abdeeva, Aysylu Galiautdinova, Yulia Filippova, Anastasiia Bairashevskaia, Aleksandr Zolotarev, Nikolay Bulanov, Audrey DunnGalvin, Anastasia Chernyavskaya, Elena Kondrikova, Anastasia Kolotilina, Svetlana Gadetskaya, Yulia V Ivanova, Irina Turina, Alina Eremeeva, Ludmila A Fedorova, Pasquale Comberiati, Diego G Peroni, Nikita Nekliudov, Jon Genuneit, Luis Felipe Reyes, Caroline L H Brackel, Lyudmila Mazankova, Alexandra Miroshina, Elmira Samitova, Svetlana Borzakova, Gail Carson, Louise Sigfrid, Janet T Scott, Sammie McFarland, Matthew Greenhawt, Danilo Buonsenso, Malcolm G Semple, John O Warner, Piero Olliaro, Ismail M Osmanov, Anatoliy A Korsunskiy, Daniel Munblit
BACKGROUND: Long-term health outcomes in children and young people (CYP) after COVID-19 infection are not well understood and studies with control groups exposed to other infections are lacking. This study aimed to investigate the incidence of post-COVID-19 condition (PCC) and incomplete recovery in CYP after hospital discharge and compare outcomes between different SARS-CoV-2 variants and non-SARS-CoV-2 infections. METHODS: A prospective exposure-stratified cohort study of individuals under 18 years old in Moscow, Russia...
February 1, 2024: BMC Medicine
#24
JOURNAL ARTICLE
Danielle M Cribb, Nevio Sarmento, Almerio Moniz, Nicholas S S Fancourt, Kathryn Glass, Anthony D K Draper, Joshua R Francis, Milena M Lay Dos Santos, Endang Soares da Silva, Benjamin G Polkinghorne, Virginia de Lourdes da Conceiҫão, Feliciano da Conceiҫão, Paulino da Silva, Joanita Jong, Martyn D Kirk, Samantha Colquhoun
In low-to-middle-income countries (LMICs), enteric pathogens contribute to child malnutrition, affecting nutrient absorption, inducing inflammation, and causing diarrhoea. This is a substantial problem in LMICs due to high disease burden, poor sanitation and nutritional status, and the cyclical nature of pathogen infection and malnutrition. This relationship remains understudied in Timor-Leste. In our pilot study of enteric pathogens and malnutrition in Dili, Timor-Leste (July 2019-October 2020), we recruited 60 infants in a birth cohort from Hospital Nacional Guido Valadares (HNGV) with up to four home visits...
2024: PloS One
#25
JOURNAL ARTICLE
Chantal D Tan, Clementien L Vermont, Joany M Zachariasse, Ulrich von Both, Enitan D Carrol, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian K Maconochie, Federico Martinon-Torres, Ruud G Nijman, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Maria Tsolia, Werner Zenz, Dace Zavadska, Henriette A Moll
BACKGROUND: The number of paediatric patients visiting the ED with non-urgent problems is increasing, leading to poor patient flow and ED crowding. Fast track aims to improve the efficiency of evaluation and discharge of low acuity patients. We aimed to identify which febrile children are suitable for a fast track based on presenting symptoms and management. METHODS: This study is part of the Management and Outcome of Fever in children in Europe study, which is an observational study including routine data of febrile children <18 years attending 12 European EDs...
January 18, 2024: Emergency Medicine Journal: EMJ
#26
Mouhammed Sleiay, Mohammed Alqreea, Ihsan Alqreea, Omar Alhasan, Bilal Sleiay, Ahmad Mostfa Kanaan, Hadi Alabdullah
INTRODUCTION AND IMPORTANCE: In addition to extra gastrointestinal hamartomatous polyps, Peutz-Jeghers syndrome (PJS), a rare but well-known hereditary disorder, generates mucocutaneous lesions that resemble certain coloured freckles and gastrointestinal symptoms. Intussusception or polyps blocking the gastrointestinal lumen are examples of PJS consequences. Additionally, the polyps may cause ongoing bleeding that causes anaemia. CASE PRESENTATION: A 15-year-old male patient with generalized stomach discomfort, frequent vomiting, and decreased appetite reported to the hospital's ambulance department...
January 2024: Annals of Medicine and Surgery
#27
JOURNAL ARTICLE
Jiyoung Kim
This review explores the complexities of autism spectrum disorder (ASD), primarily focusing on the significant eating challenges faced by children and adolescents with this neurodevelopmental condition. It is common for individuals with ASD to exhibit heightened sensitivity to various sensory aspects of food such as taste, texture, smell, and visual appeal, leading to restricted and less diverse diets. These dietary limitations are believed to contribute to an imbalance in the gut microbiota. This review elaborates on how these eating problems, coupled with the distinctive characteristics of ASD, might be influenced by and, in turn, influence the gut-brain axis, a bidirectional communication system between the gastrointestinal tract and the brain...
January 1, 2024: Soa--chʻŏngsonyŏn chŏngsin ŭihak, Journal of child & adolescent psychiatry
#28
JOURNAL ARTICLE
Jens Klein, Sarah Koens, Martin Scherer, Annette Strauß, Martin Härter, Olaf von dem Knesebeck
Frequent utilization of emergency care and overcrowded emergency departments (EDs) are highly relevant topics due to their harmful consequences for patients and staff. The present study examines variations of intended health care use in urgent and non-urgent cases among the general population. In a cross-sectional telephone survey, a sample of N = 1,204 adults residing in Hamburg, Germany, was randomly drawn. At the beginning of the survey, one of 24 different vignettes (case stories) describing symptoms of inflammatory gastrointestinal diseases were presented to the participants...
December 23, 2023: Health Policy
#29
JOURNAL ARTICLE
Sanaz Behnood, Fiona Newlands, Lauren O'Mahoney, Mahta Haghighat Ghahfarokhi, Mohammed Z Muhid, Jake Dudley, Terence Stephenson, Shamez N Ladhani, Sophie Bennett, Russell M Viner, Rowan Bhopal, Paige Kolasinska, Roz Shafran, Olivia V Swann, Andrea Takeda
BACKGROUND: Research on the long-term impact on COVID-19 in children and young people (CYP) has been published at pace. We aimed to update and refine an earlier systematic review and meta-analysis to assess the current evidence for Post-COVID-19 Condition in CYP. METHODS: Studies from the previous systematic review were combined with studies from a systematic search from July 2021 to November 2022 (registration PROSPERO CRD42021233153). Eligible studies included CYP aged ≤19 years with confirmed or probable SARS-CoV-2 infection and symptoms persisting at least 12 weeks...
2023: PloS One
#30
JOURNAL ARTICLE
Ceyda Tuna Kirsaçlioğlu
In recent decades, the patient survival is increased due to advances in intensive care units and development of modern mechanic ventilators. Unfortunately, it is not always possible to wean these children from mechanical ventilation. Recently, after placement a tracheostomy tube, these children can be supported at home with noninvasive or invasive mechanical ventilation. Most of the children who need ventilation support at home have neurological impairment. The nutritional issues and gastrointestinal (GI) complications are well defined in critically ill patients, but there are very limited studies on children with tracheostomy...
December 13, 2023: Pediatric Pulmonology
#31
JOURNAL ARTICLE
Mohammed Hasosah, Ahmed Al Sarkhy, Khalid AlQuiar, Ibrahim AlMuslami, Najat AlAhmadi, Ali Almehaidib, Adel AlShahrani, Aziz Alanazi, Muhammad Khan, Abrar Aljohani, Saqqar Alanazi, Tariq Alhassan, Ahlam AlNaqeeb, Marwah Hameedaldeen, Sanabil Albalawi, Safa Abdulmenem, Ibrahim Almehaidib, Mansour Qurashi
BACKGROUND: Functional gastrointestinal disorders (FGIDs) are common pediatric problems, but their prevalence in Saudi Arabia is unknown. We aimed to assess the prevalence of FGIDs and risk factors among children in six regions of Saudi Arabia. METHODS: This was a cross-sectional multicenter study enrolling children aged 0-48 months, attending pediatric clinics. Questionnaires evaluated the clinical history, symptoms, and sociodemographic information. FGIDs were defined according to Rome IV criteria...
December 7, 2023: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
#32
REVIEW
Shaman Rajindrajith, Wathsala Hathagoda, Eranga Ganewatte, Niranga Manjuri Devanarayana, Nikhil Thapar, Marc Benninga
INTRODUCTION: Disorders of Gut-Brain Interactions (DGBI) are a common clinical problem in children and pose significant challenges to the attending pediatrician. Radiological investigations are commonly ordered to evaluate these children. AREA COVERED: This review focuses on the current best practice of using radiological investigations in DGBIs and how novel radiological investigations could revolutionize the assessment and therapeutic approach of DGBI in children...
November 23, 2023: Expert Review of Gastroenterology & Hepatology
#33
JOURNAL ARTICLE
A S DiCriscio, D Beiler, J Smith, P Asdell, S Dickey, M DiStefano, V Troiani
BACKGROUND: Sleep disturbances, gastrointestinal problems, and atypical heart rate are commonly observed in patients with autism spectrum disorder (ASD) and may relate to underlying function of the autonomic nervous system (ANS). The overall objective of the current study was to quantitatively characterize features of ANS function using symptom scales and available electronic health record (EHR) data in a clinically and genetically characterized pediatric cohort. METHODS: We assessed features of ANS function via chart review of patient records adapted from items drawn from a clinical research questionnaire of autonomic symptoms...
October 2023: Research in Autism Spectrum Disorders
#34
JOURNAL ARTICLE
Aslı Yilmaz, Figen Işık Esenay
AIM: Nurses responsible for the care of children in the emergency department must be aware of the case profile of the pandemic era, better prepare for developing crises, and identify preventive services. The study aims to determine the pediatric emergency cases admitted during the pandemic and compare them to those during the pre-pandemic period. METHODS: The current study was designed as a single-center, retrospective, cross-sectional, and descriptive research...
November 17, 2023: Journal of Pediatric Nursing
#35
JOURNAL ARTICLE
Balaji Dhanasekaran, Rajasekaran Srinivasan, Priya Kanagamuthu, Prabakaran Somu, Namasivaya Navin R B, K Gowthame, Sarath Kumar, C Ramya Shree, S R Karthika, Greeshma U Gopan
The Cri-du-chat Syndrome (CdCs) is a rare genetic syndrome first described by Jerome Lejeune in 1963, characterized mainly by the high pitched cat like cry. The prevalence of CdCs was varied in between 1:15,000 to 1:50,000 in live birth and more common in female gender with a ratio of 4:3 [1, 2] .The condition may be accompanied by developmental and cognitive delays, poor spatial awareness, impaired ambulation, and poor sensori-motor skills. Other associated problems described include cardiovascular, renal, gastrointestinal, neurological abnormalities, preauricular tags, syndactyly, hypospadias, and cryptorchidism...
December 2023: Indian Journal of Otolaryngology and Head and Neck Surgery
#36
REVIEW
Gabrielle Williams, Christopher I Stothart, Deirdre Hahn, Jacqueline H Stephens, Jonathan C Craig, Elisabeth M Hodson
BACKGROUND: Cranberries contain proanthocyanidins (PACs), which inhibit the adherence of p-fimbriated Escherichia coli to the urothelial cells lining the bladder. Cranberry products have been used widely for several decades to prevent urinary tract infections (UTIs). This is the fifth update of a review first published in 1998 and updated in 2003, 2004, 2008, and 2012. OBJECTIVES: To assess the effectiveness of cranberry products in preventing UTIs in susceptible populations...
November 10, 2023: Cochrane Database of Systematic Reviews
#37
REVIEW
Martina Micai, Laura Maria Fatta, Letizia Gila, Angela Caruso, Tommaso Salvitti, Francesca Fulceri, Antonio Ciaramella, Roberto D'Amico, Cinzia Del Giovane, Marco Bertelli, Giovanna Romano, Holger Jens Schünemann, Maria Luisa Scattoni
This systematic review estimates the prevalence of co-occurring conditions (CCs) in children and adults with autism. A comprehensive search strategy consulting existing guidelines, diagnostic manuals, experts, carers, and autistic people was developed. PubMed and PsycInfo databases from inception to May 2022 were searched. PROSPERO registration: CRD42019132347. Two blind authors screened and extracted the data. Prevalence estimates for different CCs were summarized by using random effects models. Subgroup analyses were performed for age groups (children/adolescents vs adults) and study designs (population/registry-based vs clinical sample-based)...
October 30, 2023: Neuroscience and Biobehavioral Reviews
#38
JOURNAL ARTICLE
Loredana Matiș, Bogdana Ariana Alexandru, Radu Fodor, Lucia Georgeta Daina, Timea Claudia Ghitea, Silviu Vlad
Probiotics, also known as psychobiotics, have been linked to cognitive functions, memory, learning, and behavior, in addition to their positive effects on the digestive tract. The purpose of this study is to examine the psychoemotional effects and cognitive functioning in children with gastrointestinal disorders who undergo psychobiotherapy. A total of 135 participants, aged 5-18 years, were divided into three groups based on the pediatrician's diagnosis: Group I (Control) consisted of 37 patients (27.4%), Group II included 65 patients (48...
September 26, 2023: Biomedicines
#39
JOURNAL ARTICLE
Loredana Matiș, Bogdana Ariana Alexandru, Timea Claudia Ghitea
The interplay between the central nervous system and the intestinal environment hinges on neural, hormonal, immune, and metabolic reactions. Over decades, significant effort has gone into exploring the link between the digestive system and the brain. The primary objective of this study is to assess catecholamine levels in children with neuropsychiatric disorders. We aim to examine how these levels impact the mental and physical wellbeing of these children, with a specific focus on psychoemotional symptoms and cognitive performance...
September 22, 2023: Biomedicines
#40
JOURNAL ARTICLE
Claudio Cherchi, Elena Chiappini, Maria Beatrice Chiarini Testa, Paolo Banfi, Edvige Veneselli, Renato Cutrera
BACKGROUND: The purpose of this study is to better understand the way caregivers of patients with Rett syndrome perceive the quality of the health care services they receive and identify its main shortcomings. METHODS: A survey was distributed to all caregivers who are part of AIRETT (the Italian Association of Relatives of Patients with RS). The survey gathered information on the management of relatives of patients with Rett syndrome. RESULTS: The data refers to 52 patients, all females, with a median age of 15 years at the time of the survey...
October 21, 2023: Children
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