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Gastrointestinal problem in children

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https://www.readbyqxmd.com/read/29243034/application-of-pyridostigmine-in-pediatric-gastrointestinal-motility-disorders-a-case-series
#1
Mhd Louai Manini, Michael Camilleri, Rayna Grothe, Carlo Di Lorenzo
BACKGROUND: Gastrointestinal (GI) motility disorders are common in children. Treatment is challenging with limited medical and surgical options. Pyridostigmine, an acetyl cholinesterase inhibitor, increases acetylcholine at the neuromuscular junction promoting intestinal contractions. Little is known about the role and dosing of pyridostigmine in pediatric GI motility disorders. METHODS: We present a case series of children with GI dysmotility managed with oral pyridostigmine...
December 14, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29201769/epidemiology-diagnosis-and-risk-factors-of-helicobacter-pylori-infection-in-children
#2
REVIEW
Gokben Ozbey, Alfizah Hanafiah
H. pylori infection is a global public health problem associated with some gastrointestinal diseases in children, especially in developing countries, since prevalence of H. pylori is low in the developed world. Both noninvasive (stool antigen test, urea breath test, and blood test) and invasive (histology, rapid urease test, and microbiological culture) tests have been utilized to detect H. pylori infection. However, a single test is not reliable enough and does not provide accurate enough data to determine H...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29187193/paediatric-case-mix-in-a-rural-clinical-school-is-relevant-to-future-practice
#3
Helen M Wright, Moira A L Maley, Denese E Playford, Pam Nicol, Sharon F Evans
BACKGROUND: Exposure to a representative case mix is essential for clinical learning, with logbooks established as a way of demonstrating patient contacts. Few studies have reported the paediatric case mix available to geographically distributed students within the same medical school. Given international interest in expanding medical teaching locations to rural contexts, equitable case exposure in rural relative to urban settings is topical. The Rural Clinical School of Western Australia locates students up to 3500 km from the urban university for an academic year...
November 29, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29119251/postoperative-complications-and-long-term-functional-outcome-in-children-operated-for-idiopathic-rectal-prolapse
#4
Elin Albertsdottir, Niels Qvist
PURPOSE: The aim of the present study was to evaluate the postoperative complications and the long-term gastrointestinal functional outcome after surgical treatment for rectal prolapse on a strategy with stapled anopexy for short (< 5 cm) prolapse and Delormes procedure for longer (> 5 cm) rectal prolapse. METHODS: A total of 38 patients were included with a postoperative follow-up period ranging from 1 month to 9.1 years. Thirty patients (83%) completed the Rome III questionnaire on gastrointestinal function, with the follow-up period ranging from 2 months to 7 years...
November 8, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29102384/increased-stool-immunoglobulin-a-level-in-children-with-autism-spectrum-disorders
#5
Jiaxiu Zhou, Fusheng He, Feng Yang, Zheng Yang, Yingjun Xie, Shaoming Zhou, Jingwen Liang, Ruihuan Xu, Yan Wang, Hailiang Guo, Wenhao Zhou, Mingbang Wang
BACKGROUND: There are currently no effective treatments for the core symptoms of autism spectrum disorders (ASDs). However, alleviating gastrointestinal (GI) problems, which are prevalent in ASD patients, can significantly improve the core symptoms of autism. Previous studies have associated GI disorders in ASD patients with abnormal gut microbiota, although few disease-related microorganisms have been identified. Considering that the gut microbiome affects the intestinal immune system and the patient's behavior, and that immunoglobulin A (IgA) is the main antibody secreted by intestinal immune cells, we investigated stool IgA content as a means of understanding the gut immune status of ASD patients...
October 25, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29091821/are-gastrointestinal-and-sleep-problems-associated-with-behavioral-symptoms-of-autism-spectrum-disorder
#6
Xiao-Lei Yang, Shuang Liang, Ming-Yang Zou, Cai-Hong Sun, Pan-Pan Han, Xi-Tao Jiang, Wei Xia, Li-Jie Wu
Many children with autism spectrum disorder (ASD) suffer from concurrent medical symptoms, including gastrointestinal (GI) and sleeping problems. However, there is limited information on the correlation between co-morbidities and autistic behavioral symptoms. In this study, we estimated the prevalence of GI and sleep problems in Chinese ASD children, examined the impacts of GI and sleep problems on autistic behavioral symptoms, and investigated the factors associated with GI and sleep problems. The survey included 169 ASD and 172 healthy children...
October 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29090079/prospective-investigation-of-foxp1-syndrome
#7
Paige M Siper, Silvia De Rubeis, Maria Del Pilar Trelles, Allison Durkin, Daniele Di Marino, François Muratet, Yitzchak Frank, Reymundo Lozano, Evan E Eichler, Morgan Kelly, Jennifer Beighley, Jennifer Gerdts, Arianne S Wallace, Heather C Mefford, Raphael A Bernier, Alexander Kolevzon, Joseph D Buxbaum
BACKGROUND: Haploinsufficiency of the forkhead-box protein P1 (FOXP1) gene leads to a neurodevelopmental disorder termed FOXP1 syndrome. Previous studies in individuals carrying FOXP1 mutations and deletions have described the presence of autism spectrum disorder (ASD) traits, intellectual disability, language impairment, and psychiatric features. The goal of the present study was to comprehensively characterize the genetic and clinical spectrum of FOXP1 syndrome. This is the first study to prospectively examine the genotype-phenotype relationship in multiple individuals with FOXP1 syndrome, using a battery of standardized clinical assessments...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29063585/early-8-days-systemic-postnatal-corticosteroids-for-prevention-of-bronchopulmonary-dysplasia-in-preterm-infants
#8
REVIEW
Lex W Doyle, Jeanie L Cheong, Richard A Ehrenkranz, Henry L Halliday
BACKGROUND: Bronchopulmonary dysplasia remains a major problem in neonatal intensive care units. Persistent inflammation in the lungs is the most likely underlying pathogenesis. Corticosteroids have been used to prevent or treat bronchopulmonary dysplasia because of their potent anti-inflammatory effects. OBJECTIVES: To examine the relative benefits and adverse effects of systemic postnatal corticosteroids commenced within the first seven days of life for preterm infants at risk of developing bronchopulmonary dysplasia...
October 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29052834/laparoscopic-approach-for-removing-a-coin-trapped-in-meckel-s-diverticulum
#9
Kıvılcım Karadeniz Cerit, Aybegüm Kalyoncu, İpek Erbarut, Gürsu Kıyan, Tolga Emrullah Dağlı
Foreign body ingestion is a common problem in children. Most of these foreign bodies spontaneously pass through the gastrointestinal tract. When there is a persistent foreign body in the abdomen, it is impossible to make a diagnosis without exploration. We herein present the case of a child who was admitted to our hospital with a coin trapped in Meckel's diverticulum and our laparoscopic approach in this case. The diagnosis of Meckel's diverticulum should be considered when there is a prolonged lodgment of a foreign body in the right lower quadrant, and the laparoscopic approach is the preferred choice in these cases...
September 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29026738/two-cases-of-colonoscopic-retrieval-of-a-foreign-body-in-children-a-button-battery-and-an-open-safety-pin
#10
Eun Joo Lee, Hye Ran Yang, Jin Min Cho, Jae Sung Ko, Jin Soo Moon
Ingestion of foreign body in children is a relatively common problem among paediatric population. The foreign bodies mostly pass spontaneously through the gastrointestinal tract. However, complications can occur according to its anatomical location, the characteristics of the foreign body, and delays in management. Although the cases of ingested button batteries or sharp objects impacted at the gastrointestinal tract can be very serious, there have been very only a few cases have reported colonoscopic removal of these dangerous foreign bodies in adults, and there have been no case reports in children...
September 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29018278/coeliac-disease-to-biopsy-or-not
#11
REVIEW
Norelle R Reilly, Steffen Husby, David S Sanders, Peter H R Green
Coeliac disease is increasingly recognized as a global problem in both children and adults. Traditionally, the findings of characteristic changes of villous atrophy and increased intraepithelial lymphocytosis identified in duodenal biopsy samples taken during upper gastrointestinal endoscopy have been required for diagnosis. Although biopsies remain advised as necessary for the diagnosis of coeliac disease in adults, European guidelines for children provide a biopsy-sparing diagnostic pathway. This approach has been enabled by the high specificity and sensitivity of serological testing...
October 11, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28954536/gastrointestinal-dysfunctions-as-a-risk-factor-for-sleep-disorders-in-children-with-idiopathic-autism-spectrum-disorder-a-retrospective-cohort-study
#12
Lena M McCue, Louise H Flick, Kimberly A Twyman, Hong Xian
Sleep disorders often co-occur with autism spectrum disorder. They further exacerbate autism spectrum disorder symptoms and interfere with children's and parental quality of life. This study examines whether gastrointestinal dysfunctions increase the odds of having sleep disorders in 610 children with idiopathic autism spectrum disorder, aged 2-18 years, from the Autism Genetic Resource Exchange research program. The adjusted odds ratio for sleep disorder among those with gastrointestinal dysfunctions compared to those without was 1...
November 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28940710/experiences-in-feeding-and-gastrointestinal-dysfunction-in-children-with-charge-syndrome
#13
Meghan Macdonald, Alexandra Hudson, Angela Bladon, Elyanne Ratcliffe, Kim Blake
Feeding issues are very common in individuals with CHARGE syndrome and can lead to increased morbidity and mortality. The aim of this study was to expand upon the limited knowledge base of feeding and gastrointestinal issues in individuals with CHARGE syndrome. Parents of individuals (age range 1-18 years) with CHARGE syndrome, with or without feeding/gastrointestinal issues, were recruited through international CHARGE syndrome associations and CHARGE syndrome Facebook pages. Parents completed three questionnaires: CHARGE diagnostic characteristics; Pediatric Assessment Scale for Severe Feeding Problems © and PedsQL™ Gastrointestinal Symptoms Scale; and open-ended questions...
September 22, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28933137/rectal-perforation-in-a-42-year-old-woman-due-to-henoch-sch%C3%A3-nlein-purpura-a-case-report
#14
F Almassinokiani, A Mehdizadeh Kashi, A Musavi, S Khodaverdi, K Tahermanesh, S Ariana
Henoch-Schönlein purpura (HSP) is caused by deposition of IgA-containing immune complexes within the blood vessels. HSP mostly occurs in children and is less common in adults. In addition to palpable purpura, arthritis or arthralgia, renal disease and abdominal pain, gastrointestinal symptoms occur in 50% of children. These can be caused by gastrointestinal hemorrhage, bowel ischemia and necrosis, intussusception, and bowel perforation. In adults, intussusception is less frequent than in children. We report a 42-year-old woman referred to our hospital with acute abdominal pain...
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28887737/child-with-vomiting
#15
REVIEW
Madhusudan Samprathi, Muralidharan Jayashree
Vomiting is a common problem in children for which parents seek health care consultation. It has a varied etiology encompassing many organ systems, ranging from a benign physiological behavior to a life-threatening systemic disease. Most often, it is benign and self-limiting. Infections within and outside the gastrointestinal tract are the commonest causes. A good history and meticulous physical examination can discern the cause and help in delineating the benign cause from the sinister. Red flags include unstable vital signs, acidotic breathing, presence of bile or blood stained vomitus, features of gastrointestinal (GI) obstruction, encephalopathy and papilledema...
October 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28861653/behavioral-phenotype-of-asd-preschoolers-with-gastrointestinal-symptoms-or-food-selectivity
#16
Margherita Prosperi, Elisa Santocchi, Giulia Balboni, Antonio Narzisi, Margherita Bozza, Francesca Fulceri, Fabio Apicella, Roberta Igliozzi, Angela Cosenza, Raffaella Tancredi, Sara Calderoni, Filippo Muratori
This study investigated the prevalence and type of gastrointestinal (GI) and food selectivity (FS) symptoms in 163 preschoolers with ASD, and their possible links with core ASD features and emotional/behavioural problems. 40.5% of children with ASD had at least one severe GI symptom or FS. Preschoolers with and without GI symptoms and with and without FS were significantly different on several emotional/behavioural problems and restrictive/repetitive behaviours, whereas they did not differ significantly on performance IQ and autistic severity...
November 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28859138/inflammatory-bowel-disease-and-patterns-of-volatile-organic-compounds-in-the-exhaled-breath-of-children-a-case-control-study-using-ion-molecule-reaction-mass-spectrometry
#17
Lorenzo Monasta, Chiara Pierobon, Andrea Princivalle, Stefano Martelossi, Annalisa Marcuzzi, Francesco Pasini, Luigi Perbellini
Inflammatory bowel diseases (IBD) profoundly affect quality of life and have been gradually increasing in incidence, prevalence and severity in many areas of the world, and in children in particular. Patients with suspected IBD require careful history and clinical examination, while definitive diagnosis relies on endoscopic and histological findings. The aim of the present study was to investigate whether the alveolar air of pediatric patients with IBD presents a specific volatile organic compounds' (VOCs) pattern when compared to controls...
2017: PloS One
https://www.readbyqxmd.com/read/28835820/the-coexistence-of-psychiatric-and-gastrointestinal-problems-in-children-with-restrictive-eating-in-a-nationwide-swedish-twin-study
#18
Jakob Täljemark, Maria Råstam, Paul Lichtenstein, Henrik Anckarsäter, Nóra Kerekes
BACKGROUND: Restrictive eating problems are rare in children but overrepresented in those with neurodevelopmental problems. Comorbidities decrease wellbeing in affected individuals but research in the area is relatively scarce. This study describes phenotypes, regarding psychiatric and gastrointestinal comorbidities, in children with restrictive eating problems. METHODS: A parental telephone interview was conducted in 9- or 12-year old twins (n = 19,130) in the Child and Adolescent Twin Study in Sweden...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28828529/clinical-management-of-nocturnal-enuresis
#19
Eberhard Kuwertz-Bröking, Alexander von Gontard
Nocturnal enuresis (NE) is a common health problem. Approximately 10% of 7-year-old children wet the bed regularly during sleep. Enuresis can be categorized into monosymptomatic (MEN) and nonmonosymptomatic (NMEN) forms. MEN occurs without any other symptoms of bladder dysfunction. NMEN is associated with dysfunction of the lower urinary tract with or without daytime incontinence. The rate of comorbid gastrointestinal, behavioral, and emotional disorders is elevated depending upon the subtype of NE. A careful clinical history is fundamental to the evaluation of enuresis...
August 21, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28804748/health-of-children-living-near-coal-ash
#20
Clara G Sears, Kristina M Zierold
Coal ash, generated from coal combustion, is composed of small particles containing metals and other elements, such as metalloids. Coal ash is stored in open-air impoundments, frequently near communities. The objective of this study was to evaluate the prevalence of health and sleep problems in children living near coal ash and compare these prevalences to children not living near coal ash. In 2013 to 2014, we conducted a cross-sectional survey in a community adjacent to coal ash storage sites and a community not exposed to coal ash...
2017: Global Pediatric Health
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