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Gastrointestinal problem in children

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https://www.readbyqxmd.com/read/29684771/coenzyme-q-10-supplementation-reduces-oxidative-stress-and-decreases-antioxidant-enzyme-activity-in-children-with-autism-spectrum-disorders
#1
Elham Mousavinejad, Mohammad Ali Ghaffari, Forough Riahi, Maryam Hajmohammadi, Zeinab Tiznobeyk, Masoumeh Mousavinejad
Antioxidants and oxidative stress can participate in pathobiochemical mechanisms of autism spectrum disorders (ASDs). The aim was to identify the effects of early CoQ10 supplementation on oxidative stress in children with ASDs. Ninety children with ASDs were included in this study, based on DSM-IV criteria and using Childhood Autism Rating Scale (CARS) scores. Concentrations of CoQ10 , MDA, total antioxidant status (TAS) assay, and antioxidant enzymes (superoxide dismutase or SOD and glutathione peroxidase or GPx) activity were determined in serum before and after 100 days of supportive therapy with CoQ10 at daily doses of 30 and 60 mg...
April 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29644760/housing-conditions-associated-with-recurrent-gastrointestinal-infection-in-urban-aboriginal-children-in-nsw-australia-findings-from-search
#2
Melanie J Andersen, Adam Skinner, Anna B Williamson, Peter Fernando, Darryl Wright
OBJECTIVE: To examine the associations between housing and gastrointestinal infection in Aboriginal children in urban New South Wales. METHODS: A total of 1,398 Aboriginal children were recruited through four Aboriginal Community Controlled Health Services. Multilevel regression modelling of survey data estimated associations between housing conditions and recurrent gastrointestinal infection, adjusting for sociodemographic and health factors. RESULTS: Of the sample, 157 children (11%) had recurrent gastrointestinal infection ever and 37 (2...
April 12, 2018: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29615329/individuals-affected-by-eosinophilic-gastrointestinal-disorders-have-complex-unmet-needs-and-frequently-experience-unique-barriers-to-care
#3
Girish Hiremath, Ellyn Kodroff, Mary J Strobel, Melissa Scott, Wendy Book, Cathy Reidy, Shay Kyle, Denise Mack, Kathleen Sable, Pablo Abonia, Jonathan Spergel, Sandeep K Gupta, T Glenn Furuta, Marc E Rothenberg, Evan S Dellon
INTRODUCTION: Eosinophilic gastrointestinal disorders (EGIDs) are a rare but emerging healthcare problem. Patient advocacy groups (PAGs) have an important role in representing the EGID community, and serve as valuable research partners. By leveraging the partnership between medical researchers and PAGs, we examined the unmet needs and barriers to care perceived by individuals affected by EGIDs. Next, we examined if these varied between adult EGID patients and adult caregivers of children with EGID...
March 31, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29607385/assessment-of-nutritional-problems-in-pediatric-patients-with-cancer-and-the-information-needs-of-their-parents-a-parental-perspective
#4
Tuba Arpaci, Ebru Kilicarslan Toruner, Naime Altay
Objective: The majority of problems and symptoms occur in the gastrointestinal system in children with cancer. Parents have difficulty in coping with the nutritional problems and changing routines of children and need support in this respect. This study aimed to assess the nutritional problems of children with cancer and the information needs of their parents. Methods: This descriptive study was performed among children with cancer aged 3-18 years and their parents ( n = 69)...
April 2018: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29578446/self-perceived-health-status-and-illnesses-among-internally-displaced-people-in-georgia
#5
G Kamkamidze, M Tabatadze, M Kajaia, L Gulbiani, M Shakhnazarova, L Geradze, M Butsashvili
Georgia had several waves of internally displaced people (IDPs) as a result of military conflicts on the territories of Abkhazia and Samachablo starting from 1990's with the latest large wave in 2008. Most of the IDPs live in compact settlements, such as old administrative buildings or specially constructed camps. In both cases, living conditions and social-economic status of IDPs are below Georgia's national average. There is extremely limited data on the health status of the IDPs in Georgia. Health Research Union (HRU) with support from ELRHA/R2HC program conducted a survey to study health service utilization and expenditures among IDPs, and measure the effect of targeted intervention versus untargeted, integrated approach to health financing...
February 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29577380/the-effect-of-medical-and-operative-birth-interventions-on-child-health-outcomes-in-the-first-28-days-and-up-to-5-years-of-age-a-linked-data-population-based-cohort-study
#6
Lilian L Peters, Charlene Thornton, Ank de Jonge, Ali Khashan, Mark Tracy, Soo Downe, Esther I Feijen-de Jong, Hannah G Dahlen
BACKGROUND: Spontaneous vaginal birth rates are decreasing worldwide, while cesarean delivery, instrumental births, and medical birth interventions are increasing. Emerging evidence suggests that birth interventions may have an effect on children's health. Therefore, the aim of our study was to examine the association between operative and medical birth interventions on the child's health during the first 28 days and up to 5 years of age. METHODS: In New South Wales (Australia), population-linked data sets were analyzed, including data on maternal characteristics, child characteristics, mode of birth, interventions during labor and birth, and adverse health outcomes of the children (ie, jaundice, feeding problems, hypothermia, asthma, respiratory infections, gastrointestinal disorders, other infections, metabolic disorder, and eczema) registered with the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes...
March 25, 2018: Birth
https://www.readbyqxmd.com/read/29526319/consensus-on-the-diagnosis-treatment-and-follow-up-of-patients-with-duchenne-muscular-dystrophy
#7
A Nascimento Osorio, J Medina Cantillo, A Camacho Salas, M Madruga Garrido, J J Vilchez Padilla
INTRODUCTION: Duchenne muscular dystrophy (DMD) is the most common myopathy in children, with a worldwide prevalence of approximately 0.5 cases per 10,000 male births. It is characterised by a progressive muscular weakness manifesting in early childhood, with the subsequent appearance of musculoskeletal, respiratory, and cardiac complications, causing disability, dependence, and premature death. Currently, DMD is mainly managed with multidisciplinary symptomatic treatment, with favourable results in terms of the progression of the disease...
March 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29486708/functional-gastrointestinal-diseases-and-psychological-maladjustment-personality-traits-and-quality-of-life
#8
Nishadi Ranasinghe, Niranga Manjuri Devanarayana, Shaman Rajindrajith, Madusanka S Perera, Samudu Nishanthinie, Tania Warnakulasuriya, Piyanjali Thamesha de Zoysa
BACKGROUND: Chronic abdominal pain is a common worldwide problem and known to be associated with psychological problems. This study evaluated the association between abdominal pain-predominant functional gastrointestinal disorders (AP-FGIDs), psychological maladjustment and personality traits in adolescents. METHODS: Adolescents aged 13-18 years were recruited from 5 randomly selected schools in Ampara district of Sri Lanka. AP-FGIDs were diagnosed using Rome III criteria...
February 27, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29456191/comparative-efficacy-of-low-dose-versus-standard-dose-azithromycin-for-patients-with-yaws-a-randomised-non-inferiority-trial-in-ghana-and-papua-new-guinea
#9
Michael Marks, Oriol Mitjà, Christian Bottomley, Cynthia Kwakye, Wendy Houinei, Mathias Bauri, Paul Adwere, Abdul A Abdulai, Fredrick Dua, Laud Boateng, James Wangi, Sally-Ann Ohene, Regina Wangnapi, Shirley V Simpson, Helen Miag, Kennedy K Addo, Laud A Basing, Damien Danavall, Kai H Chi, Allan Pillay, Ronald Ballard, Anthony W Solomon, Cheng Y Chen, Sibauk V Bieb, Yaw Adu-Sarkodie, David C W Mabey, Kingsley Asiedu
BACKGROUND: A dose of 30 mg/kg of azithromycin is recommended for treatment of yaws, a disease targeted for global eradication. Treatment with 20 mg/kg of azithromycin is recommended for the elimination of trachoma as a public health problem. In some settings, these diseases are co-endemic. We aimed to determine the efficacy of 20 mg/kg of azithromycin compared with 30 mg/kg azithromycin for the treatment of active and latent yaws. METHODS: We did a non-inferiority, open-label, randomised controlled trial in children aged 6-15 years who were recruited from schools in Ghana and schools and the community in Papua New Guinea...
February 15, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29406791/functional-abdominal-pain-disorders-in-children
#10
Shaman Rajindrajith, Judith Zeevenhooven, Niranga Manjuri Devanarayana, Bonaventure Jayasiri Crispus Perera, Marc A Benninga
Chronic abdominal pain is a common problem in pediatric practice. The majority of cases fulfill the Rome IV criteria for functional abdominal pain disorders (FAPDs). At times, these disorders may lead to rather serious repercussions. Area covered: We have attempted to cover current knowledge on epidemiology, pathophysiology, risk factors related to pathophysiology, clinical evaluation and management of children with FAPDs. Expert commentary: FAPDs are a worldwide problem with a pooled prevalence of 13.5%. There are a number of predisposing factors and pathophysiological mechanisms including stressful events, child maltreatment, visceral hypersensitivity, altered gastrointestinal motility and change in intestinal microbiota...
April 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29344053/an-overview-of-exposure-to-ethanol-containing-substances-and-ethanol-intoxication-in-children-based-on-three-illustrated-cases
#11
REVIEW
Kam Lun Hon, Alexander Kc Leung, Eddie Cheung, Bryan Lee, Michelle Mc Tsang, Alcy R Torres
Alcohol addiction and intoxication are major health problems worldwide. Acute alcohol intoxication is well reported in adults and adolescents but less frequently reported in children of younger ages. We report three anonymized cases of pediatric ethanol exposure and illustrate the different mechanisms of intoxication. In all cases, a focused history is the key to prompt diagnosis and timely management. Physicians should be aware of this potential poison in children presented with acute confusional or encephalopathic state...
2018: Drugs in Context
https://www.readbyqxmd.com/read/29277311/targeting-gut-microbiome-a-novel-and-potential-therapy-for-autism
#12
REVIEW
Yongshou Yang, Jinhu Tian, Bo Yang
Autism spectrum disorder (ASD) is a severely neurodevelopmental disorder that impairs a child's ability to communicate and interact with others. Children with neurodevelopmental disorder, including ASD, are regularly affected by gastrointestinal problems and dysbiosis of gut microbiota. On the other hand, humans live in a co-evolutionary association with plenty of microorganisms that resident on the exposed and internal surfaces of our bodies. The microbiome, refers to the collection of microbes and their genetic material, confers a variety of physiologic benefits to the host in many key aspects of life as well as being responsible for some diseases...
February 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29262469/-association-between-behavioral-problems-and-gastrointestinal-disorders-among-children-with-autism-spectrum-disorder
#13
J Zhu, M Guo, T Yang, X Lai, Y Y Lei, M L He, J Chen, T Y Li
Objective: To investigate the relationship between gastrointestinal disorders (GID) and core symptoms or behavioral problems among the children with autism spectrum disorder (ASD) . Method: Totally 328 children with ASD and 202 normal controls were enrolled in this cross-sectional study from August 2013 to October 2016. The information about the gastrointestinal disorders, behavioral and emotional problems was collected by using questionnaires. Childhood Autism Rating Scale (CARS), Autism Behavior Checklist (ABC) were used to assess the core symptoms of the children with ASD...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29249003/mitochondrial-disease-in-children-the-nephrologist-s-perspective
#14
Paula Pérez-Albert, Carmen de Lucas Collantes, Miguel Ángel Fernández-García, Teresa de Rojas, Cristina Aparicio López, Luis Gutiérrez-Solana
Mitochondrial diseases (MD) are a heterogeneous group of clinical syndromes characterized by the involvement of different organ systems. They constitute the most prevalent hereditary metabolic disease group. OBJECTIVE: To review the importance of the kidney in MD from the nephrologist's perspective within the setting of a pediatric tertiary reference center. STUDY DESIGN: Retrospective study of children (<18 years) with MD followed between 2000 and 2016 at a tertiary Spanish center...
December 17, 2017: JIMD Reports
https://www.readbyqxmd.com/read/29243034/application-of-pyridostigmine-in-pediatric-gastrointestinal-motility-disorders-a-case-series
#15
Mhd Louai Manini, Michael Camilleri, Rayna Grothe, Carlo Di Lorenzo
BACKGROUND: Gastrointestinal (GI) motility disorders are common in children. Treatment is challenging with limited medical and surgical options. Pyridostigmine, an acetyl cholinesterase inhibitor, increases acetylcholine at the neuromuscular junction promoting intestinal contractions. Little is known about the role and dosing of pyridostigmine in pediatric GI motility disorders. METHODS: We present a case series of children with GI dysmotility managed with oral pyridostigmine...
April 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29201769/epidemiology-diagnosis-and-risk-factors-of-helicobacter-pylori-infection-in-children
#16
REVIEW
Gokben Ozbey, Alfizah Hanafiah
H. pylori infection is a global public health problem associated with some gastrointestinal diseases in children, especially in developing countries, since prevalence of H. pylori is low in the developed world. Both noninvasive (stool antigen test, urea breath test, and blood test) and invasive (histology, rapid urease test, and microbiological culture) tests have been utilized to detect H. pylori infection. However, a single test is not reliable enough and does not provide accurate enough data to determine H...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29187193/paediatric-case-mix-in-a-rural-clinical-school-is-relevant-to-future-practice
#17
Helen M Wright, Moira A L Maley, Denese E Playford, Pam Nicol, Sharon F Evans
BACKGROUND: Exposure to a representative case mix is essential for clinical learning, with logbooks established as a way of demonstrating patient contacts. Few studies have reported the paediatric case mix available to geographically distributed students within the same medical school. Given international interest in expanding medical teaching locations to rural contexts, equitable case exposure in rural relative to urban settings is topical. The Rural Clinical School of Western Australia locates students up to 3500 km from the urban university for an academic year...
November 29, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29119251/postoperative-complications-and-long-term-functional-outcome-in-children-operated-for-idiopathic-rectal-prolapse
#18
Elin Albertsdottir, Niels Qvist
PURPOSE: The aim of the present study was to evaluate the postoperative complications and the long-term gastrointestinal functional outcome after surgical treatment for rectal prolapse on a strategy with stapled anopexy for short (< 5 cm) prolapse and Delormes procedure for longer (> 5 cm) rectal prolapse. METHODS: A total of 38 patients were included with a postoperative follow-up period ranging from 1 month to 9.1 years. Thirty patients (83%) completed the Rome III questionnaire on gastrointestinal function, with the follow-up period ranging from 2 months to 7 years...
January 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29102384/increased-stool-immunoglobulin-a-level-in-children-with-autism-spectrum-disorders
#19
Jiaxiu Zhou, Fusheng He, Feng Yang, Zheng Yang, Yingjun Xie, Shaoming Zhou, Jingwen Liang, Ruihuan Xu, Yan Wang, Hailiang Guo, Wenhao Zhou, Mingbang Wang
BACKGROUND: There are currently no effective treatments for the core symptoms of autism spectrum disorders (ASDs). However, alleviating gastrointestinal (GI) problems, which are prevalent in ASD patients, can significantly improve the core symptoms of autism. Previous studies have associated GI disorders in ASD patients with abnormal gut microbiota, although few disease-related microorganisms have been identified. Considering that the gut microbiome affects the intestinal immune system and the patient's behavior, and that immunoglobulin A (IgA) is the main antibody secreted by intestinal immune cells, we investigated stool IgA content as a means of understanding the gut immune status of ASD patients...
October 25, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29091821/are-gastrointestinal-and-sleep-problems-associated-with-behavioral-symptoms-of-autism-spectrum-disorder
#20
Xiao-Lei Yang, Shuang Liang, Ming-Yang Zou, Cai-Hong Sun, Pan-Pan Han, Xi-Tao Jiang, Wei Xia, Li-Jie Wu
Many children with autism spectrum disorder (ASD) suffer from concurrent medical symptoms, including gastrointestinal (GI) and sleeping problems. However, there is limited information on the correlation between co-morbidities and autistic behavioral symptoms. In this study, we estimated the prevalence of GI and sleep problems in Chinese ASD children, examined the impacts of GI and sleep problems on autistic behavioral symptoms, and investigated the factors associated with GI and sleep problems. The survey included 169 ASD and 172 healthy children...
January 2018: Psychiatry Research
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