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Glycemic variability

John I Shin, Kevin Phan, Parth Kothari, Jun S Kim, Javier Z Guzman, Samuel K Cho
STUDY DESIGN: This is a retrospective analysis of administrative database. OBJECTIVE: To elucidate the effect of glycemic control on surgical outcomes of middle-aged and elderly idiopathic scoliosis patients undergoing spinal fusion surgery. SUMMARY OF BACKGROUND DATA: Diabetes mellitus (DM) is a condition thought to adversely affect outcomes of spine surgery. However, no study has stratified glycemic control levels and their impact on outcome for idiopathic scoliosis patients receiving a spinal fusion surgery...
October 19, 2016: Clinical Spine Surgery
Yancui Huang, Eunyoung Park, Indika Edirisinghe, Britt M Burton-Freeman
Strawberries, rich in anthocyanins, attenuate meal-induced postprandial increases in inflammation and oxidative stress as well as improved post-meal insulin responses. While previous studies have focused on the health effects of strawberry consumption ingested with a meal, this study aimed to determine if consuming strawberries at alternative times near a meal would influence meal-induced oxidative-immuno-metabolic outcomes. Fourteen overweight healthy adults participated in a 3-arm, single-blinded, crossover clinical trial delivering a strawberry drink at 1 of 3 different time points: 2 hours before a standard meal, with the meal, or 2 hours after the meal...
October 20, 2016: Food & Function
Hayley A Young, Heather Watkins
Reducing the glycemic load (GL) of the diet may benefit appetite control but its utility is complicated by psychological influences on eating. Disinhibited behaviour, a risk factor for overconsumption, is characterized by reduced prefrontal cortex activity, which in turn modulates vagal tone; a phenomenon associated with glucoregulation. This double blind randomised controlled trial explored for the first time the influence of disinhibited eating and vagal tone (heart rate variability (HRV)) on hunger and the postprandial response to GL...
October 20, 2016: Scientific Reports
Natalia Sanchez-Aguadero, Rosario Alonso-Dominguez, Jose I Recio-Rodriguez, Maria C Patino-Alonso, Manuel A Gomez-Marcos, Carlos Martin-Cantera, Yolanda Schmolling-Guinovart, Luis Garcia-Ortiz
OBJECTIVE: To analyze the relationship between dietary glycemic index (GI) and retinal microvasculature in adults. METHODS: This was a cross-sectional study of 300 subjects from the EVIDENT II study. Dietary GI was calculated using a validated, semi-quantitative food frequency questionnaire. Retinal photographs were digitized, temporal vessels were measured in an area 0.5-1 disc diameter from the optic disc and arteriolar-venular index (AVI) was estimated with semi-automated software...
October 18, 2016: Nutrition Journal
Efraín Rodríguez-Vigil, Migdalia Rodríguez-Chacón, José J Ruiz Valcarcel
OBJECTIVE: The objective of this study was to assess the current relationship between certain demographics and chemical factors, and the risk of cardiovascular complications, within a Puerto Rican population with diabetes mellitus. RESEARCH DESIGN AND METHODS: A total of 2075 patients with diabetes mellitus were retrospectively evaluated to determine the influence of certain demographics and chemical variables on the appearance of cardiovascular complications. A group of demographic and laboratory variables were analyzed...
2016: BMJ Open Diabetes Research & Care
Viswanathan Mohan, Sunil Jain, Jothydev Kesavadev, Manoj Chawla, Abhay Mutha, Vijay Viswanathan, Banshi Saboo, Rajiv Kovil, Ambrish Mithal, Dharmen Punatar, John Shin
BACKGROUND: Retrospective continuous glucose monitoring (CGM) studies may provide healthcare professionals (HCPs) with better understanding of glycemic patterns in patients with type 2 diabetes (T2D) and thereby support patient education and appropriate therapeutic interventions. METHODS: Adults with T2D and A1C values between 8% and 10% were eligible for this 3-month study. Patients were scheduled for 5 visits that included baseline and a month-2 retrospective CGM study (iPro2, Medtronic) followed by data review and therapy modifications...
April 2016: Journal of the Association of Physicians of India
Shashank R Joshi
No abstract text is available yet for this article.
April 2016: Journal of the Association of Physicians of India
K Cambra, A Galbete, L Forga, O Lecea, M J Ariz, C Moreno-Iribas, F Aizpuru, B Ibañez
BACKGROUND: We aimed to determine the degree to which control targets of glycaemia and cardiovascular risk factors were achieved among patients with type 2 diabetes and to investigate sex- and age-related differences in this population. METHODS: This cross-sectional, population-based study was conducted in Spain. Glycated hemoglobin (HbA1c), blood pressure, LDL-c, HDL-c, triglycerides, BMI, and smoking history were obtained from electronic clinical primary care records (n = 32,638 cases)...
October 12, 2016: BMC Family Practice
Leonor García Maset, Lidia Blasco González, Gonzalo Llop Furquet, Francisco Montes Suay, Roberto Hernández Marco
BACKGROUND: Time series analysis provides information on blood glucose dynamics that is unattainable with conventional glycemic variability (GV) indices. To date, no studies have been published on these parameters in pediatric patients with type 1 diabetes. Our aim is to evaluate the relationship between time series analysis and conventional GV indices, and glycosylated hemoglobin (HbA1c) levels. METHODS: This is a transversal study of 41 children and adolescents with type 1 diabetes...
October 11, 2016: Diabetes Technology & Therapeutics
Po-Ya Chang, Li-Nien Chien, Yuh-Feng Lin, Wen-Ta Chiu, Hung-Yi Chiou
BACKGROUND AND AIM: Hyperglycemic, hypertension, and lipid abnormalities are risk factors for diabetic kidney disease However, no study has discussed the association of the simultaneous control of glycemic, blood pressure, and lipids with renal function among diabetes patients. Thus, this study examined the interactive effects of the intensive control of all 3 conditions on the progression of renal function. MATERIALS AND METHODS: The study population was derived from eight hospitals in Taiwan from October 2008 to April 2015...
October 2, 2016: European Journal of Internal Medicine
Masafumi Koga, Rie Matsumoto
BACKGROUNDS: The effect of alcohol consumption on glycemic control indicators is not well known. In this study, we studied the effect of alcohol consumption on the plasma glucose and glycemic control indicators in non-diabetic men. METHODS: The study enrolled 300 non-diabetic men who received a complete medical checkup [age: 52.8 ± 6.5 years, body mass index (BMI): 24.4 ± 2.8 kg/m(2)]. The subjects were divided into four groups by the amount of alcohol consumed, and the plasma glucose, HbA1c, glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG) levels of the groups were compared...
October 4, 2016: Annals of Clinical Biochemistry
Liangjian Lu, Albert Koulman, Clive J Petry, Benjamin Jenkins, Lee Matthews, Ieuan A Hughes, Carlo L Acerini, Ken K Ong, David B Dunger
OBJECTIVE: To investigate the relationship between early second trimester serum lipidomic variation and maternal glycemic traits at 28 weeks, and to identify predictive lipid biomarkers for gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: Prospective study of 817 pregnant women (discovery cohort, n = 200; validation cohort, n = 617) who provided an early second trimester serum sample, and underwent an oral glucose tolerance test (OGTT) at 28 weeks...
October 4, 2016: Diabetes Care
Jennifer N Clements, Tiffaney Threatt, Eileen Ward, Kayce M Shealy
Concentrated insulin analogs have recently been approved and are available for clinical use in the management of diabetes mellitus. One new product is insulin glargine U-300 (Sanofi), a basal concentrated insulin of 300 U/mL. Several studies have been conducted and completed evaluating blood samples for the pharmacokinetics of insulin glargine U-300 and euglycemic clamp procedures for the pharmacodynamics. This concentrated insulin has a low within-day variability and high day-to-day reproducibility, allowing for a more constant and prolonged duration of action, compared with insulin glargine U-100 (100 U/mL)...
October 4, 2016: Clinical Pharmacokinetics
Neil E Hill, Christopher Campbell, Paul Buchanan, Midge Knight, Ian F Godsland, Nick S Oliver
BACKGROUND: Increasing numbers of people with diabetes are adopting exercise programs. Fear of hypoglycemia, hypoglycemia itself, and injuries are major issues for many people with diabetes undertaking physical activity. The purpose of this study was to investigate the effects of type 1 diabetes mellitus on the risk of hypoglycemia, glycemic variability, exercise performance, changes in body composition, changes in insulin dosage, and psychosocial well-being during a multiday endurance exercise event...
September 30, 2016: Journal of Diabetes Science and Technology
Giovanni Landoni, Antonio Pisano, Vladimir Lomivorotov, Gabriele Alvaro, Ludhmila Hajjar, Gianluca Paternoster, Caetano Nigro Neto, Nicola Latronico, Evgeny Fominskiy, Laura Pasin, Gabriele Finco, Rosetta Lobreglio, Maria Luisa Azzolini, Giuseppe Buscaglia, Alberto Castella, Marco Comis, Adele Conte, Massimiliano Conte, Francesco Corradi, Erika Dal Checco, Giovanni De Vuono, Marco Ganzaroli, Eugenio Garofalo, Gordana Gazivoda, Rosalba Lembo, Daniele Marianello, Martina Baiardo Redaelli, Fabrizio Monaco, Valentina Tarzia, Marta Mucchetti, Alessandro Belletti, Paolo Mura, Mario Musu, Giovanni Pala, Massimiliano Paltenghi, Vadim Pasyuga, Desiderio Piras, Claudio Riefolo, Agostino Roasio, Laura Ruggeri, Francesco Santini, Andrea Székely, Luigi Verniero, Antonella Vezzani, Alberto Zangrillo, Rinaldo Bellomo
OBJECTIVE: Of the 230 million patients undergoing major surgical procedures every year, more than 1 million will die within 30 days. Thus, any nonsurgical interventions that help reduce perioperative mortality might save thousands of lives. The authors have updated a previous consensus process to identify all the nonsurgical interventions, supported by randomized evidence, that may help reduce perioperative mortality. DESIGN AND SETTING: A web-based international consensus conference...
August 2, 2016: Journal of Cardiothoracic and Vascular Anesthesia
R Barazzoni, N E P Deutz, G Biolo, S Bischoff, Y Boirie, T Cederholm, C Cuerda, N Delzenne, M Leon Sanz, O Ljungqvist, M Muscaritoli, C Pichard, J C Preiser, P Sbraccia, P Singer, L Tappy, B Thorens, A Van Gossum, R Vettor, P C Calder
Growing evidence underscores the important role of glycemic control in health and recovery from illness. Carbohydrate ingestion in the diet or administration in nutritional support is mandatory, but carbohydrate intake can adversely affect major body organs and tissues if resulting plasma glucose becomes too high, too low, or highly variable. Plasma glucose control is especially important for patients with conditions such as diabetes or metabolic stress resulting from critical illness or surgery. These patients are particularly in need of glycemic management to help lessen glycemic variability and its negative health consequences when nutritional support is administered...
September 19, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Charles E Edmiston, David J Leaper
BACKGROUND: Intra-operative surgical site irrigation (lavage) is common practice in surgical procedures in general, with all disciplines advocating some form of irrigation before incision closure. This practice, however, has been neither standardized nor is there compelling evidence that it effectively reduces the risk of surgical site infection (SSI). This narrative review addresses the laboratory and clinical evidence that is available to support the practice of irrigation of the abdominal cavity and superficial/deep incisional tissues, using specific irrigation solutions at the end of an operative procedure to reduce the microbial burden at wound closure...
September 27, 2016: Surgical Infections
Anshu Srivastava, Saurabh Chaturvedi, Preeti Dabadghao, Amrita Mathias, Umesh Shukla, Uttam Singh, Surender Kumar Yachha
BACKGROUND: Type 1 diabetes (T1D) patients are at an increased risk of having celiac disease (CD). We evaluated the prevalence and clinical profile of CD in children and adolescents with T1D and reviewed the Indian literature to determine prevalence and reasons for variability. METHODS: In this cross-sectional study, subjects with T1D were prospectively evaluated with a demographic and gastrointestinal (GI) questionnaire, human IgA-tissue transglutaminase (IgA-tTGA), and endoscopic duodenal biopsy in serology positive patients...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Tsutomu Namikawa, Masaya Munekage, Hiroyuki Kitagawa, Tomoaki Yatabe, Hiromichi Maeda, Yuuki Tsukamoto, Kenichi Hirano, Takuji Asano, Yoshihiko Kinoshita, Kazuhiro Hanazaki
This clinical study aimed to compare a novel and conventional artificial pancreas (AP) used in surgical patients for perioperative glycemic control, with respect to usability, blood glucose measurements, and glycemic control characteristics. From July in 2010 to March in 2015, 177 patients underwent perioperative glycemic control using a novel AP. Among them, 166 patients were eligible for inclusion in this study. Intensive insulin therapy (IIT) targeting a blood glucose range of 80-110 mg/dL was implemented in 82 patients (49 %), and the remaining 84 patients (51 %) received a less-intensive regime of insulin therapy...
September 20, 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
A Chico, L Herranz, R Corcoy, O Ramírez, M M Goya, J Bellart, S González-Romero, M Codina, P Sánchez, A Cortázar, D Acosta, M J Picón, J A Rubio, A Megía, M A Sancho, M Balsells, E Solá, N L González, J López-López
OBJECTIVE: To examine the potential role of the type of basal insulin on glycemic control and maternal and foetal outcomes in pregnant women with type 1 diabetes (T1DM). STUDY DESIGN: Retrospective cohort study of pregnancies attended at 18 Spanish tertiary hospitals. INCLUSION CRITERIA: T1DM, singleton pregnancies, delivery between 2002-2010, and use of the same basal and prandial insulin from before pregnancy until delivery. RESULTS: A total of 1534 pregnancies were included...
September 9, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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