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Glycemic variability

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https://www.readbyqxmd.com/read/28525822/the-interplay-between-diabetes-depression-and-affective-temperaments-a-structural-equation-model
#1
Martino Belvederi Murri, Sara Mamberto, Lucia Briatore, Chiara Mazzucchelli, Mario Amore, Renzo Cordera
BACKGROUND: Diabetes and depression are reciprocally linked, but few studies modeled their interplay considering the influence of affective temperaments (AT) and demographic factors. METHODS: Participants with type 1 and type 2 diabetes (T1DM and T2DM, n=279) recruited from Diabetes Units were assessed with the Beck Depression Inventory (BDI), Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A), Morisky Medication Adherence Scale (MMAS), Diabetes Distress Scale (DDS) and Cumulative Illness Rating Scales (CIRS)...
May 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28524766/psychological-flexibility-among-youth-with-type-1-diabetes-relating-patterns-of-acceptance-adherence-and-stress-to-adaptation
#2
Rebecca C Kamody, Kristoffer S Berlin, Tiffany M Rybak, Kimberly L Klages, Gabrielle G Banks, Jeanelle S Ali, Ramin Alemzadeh, Robert J Ferry, Alicia M Diaz Thomas
Psychological flexibility, a complex concept encompassing both acceptance and action related factors, has been identified as a target for intervention for diabetes management. Research suggests acceptance, self-management, and stress, all factors that influence psychological flexibility, have an impact on adaptation to type 1 diabetes (T1D) by youth independently. However, yet to be explored is individually varying patterns of these variables and how they may relate to diabetes adaptation outcomes. The present study aimed to establish individual variations of patterns of these factors to derive profiles of psychological flexibility, and examine their relations to the adaptation outcomes of glycemic control and health-related quality of life...
May 19, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28510719/trajectories-of-glycemic-control-over-adolescence-and-emerging-adulthood-an-11-year-longitudinal-study-of-youth-with-type-1%C3%A2-diabetes
#3
Vicki S Helgeson, Abigail Kunz Vaughn, Howard Seltman, Trevor Orchard, Ingrid Libman, Dorothy Becker
To identify trajectories of glycemic control over adolescence and emerging adulthood and to test whether demographic and psychosocial variables distinguished these trajectories. We enrolled 132 youth with type 1 diabetes when they were average age 12 and followed them for 11 years. We used group-based trajectory modeling to identify distinct patterns of glycemic control, and examined whether age 12 demographic and psychosocial variables distinguished the subsequent trajectories. We identified 5 trajectories of glycemic control: stable on target, stable above target, volatile late peak, stable high, and inverted U...
May 16, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28503154/sedentary-patterns-physical-activity-and-cardiorespiratory-fitness-in-association-to-glycemic-control-in-type-2-diabetes-patients
#4
Luís B Sardinha, João P Magalhães, Diana A Santos, Pedro B Júdice
Background: Sedentary behavior has been considered an independent risk factor for type-2 diabetes (T2D), with a negative impact on several physiological outcomes, whereas breaks in sedentary time (BST) have been proposed as a viable solution to mitigate some of these effects. However, little is known about the independent associations of sedentary pursuits, physical activity, and cardiorespiratory fitness (CRF) variables with glycemic control. We investigated the independent associations of total sedentary time, BST, moderate-to-vigorous physical activity (MVPA), and CRF with glycemic outcomes in patients with T2D...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28500217/glucose-peaks-and-the-risk-of-dementia-and-20-year-cognitive-decline
#5
Andreea M Rawlings, A Richey Sharrett, Thomas H Mosley, Shoshana H Ballew, Jennifer A Deal, Elizabeth Selvin
OBJECTIVE: Hemoglobin A1c (HbA1c), a measure of average blood glucose level, is associated with the risk of dementia and cognitive impairment. However, the role of glycemic variability or glucose excursions in this association is unclear. We examined the association of glucose peaks in midlife, as determined by the measurement of 1,5-anhydroglucitol (1,5-AG) level, with the risk of dementia and 20-year cognitive decline. RESEARCH DESIGN AND METHODS: Nearly 13,000 participants from the Atherosclerosis Risk in Communities (ARIC) study were examined...
May 12, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28495320/comparison-of-2-intravenous-insulin-protocols-glycemia-variability-in-critically-ill-patients
#6
Marta Gómez-Garrido, Ana M Rodilla-Fiz, María Girón-Lacasa, Laura Rodríguez-Rubio, Anselmo Martínez-Blázquez, Fernando Martínez-López, María Dolores Pardo-Ibáñez, Juan M Núñez-Marín
OBJECTIVE: Glycemic variability is an independent predictor of mortality in critically ill patients. The objective of this study was to compare two intravenous insulin protocols in critically ill patients regarding the glycemic variability. MATERIAL AND METHODS: This was a retrospective observational study performed by reviewing clinical records of patients from a Critical Care Unit for 4 consecutive months. First, a simpler Scale-Based Intravenous Insulin Protocol (SBIIP) was reviewed and later it was compared for the same months of the following year with a Sliding Scale-Based Intravenous Insulin Protocol (SSBIIP)...
May 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28495319/clinical-characteristics-and-mortality-in-patients-treated-in-a-multidisciplinary-diabetic-foot-unit
#7
José Antonio Rubio, Sara Jiménez, Julia Álvarez
BACKGROUND AND OBJECTIVE: This study reviews the clinical characteristics of patients with diabetic foot ulcer treated in a Multidisciplinary Diabetic Foot Unit (MDFU) and analyzes the mortality and factors associated with its survival. MATERIAL AND METHODS: Data from all patients who attended the MDFU for the first time for a diabetic foot ulcer during the 2008-2014 period were analized. The patients were followed until their death or until June 30, 2016, for up to 8 years...
May 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28490337/effect-of-sitagliptin-on-the-echocardiographic-parameters-of-left-ventricular-diastolic-function-in-patients-with-type-2-diabetes-a-subgroup-analysis-of-the-prologue-study
#8
Hirotsugu Yamada, Atsushi Tanaka, Kenya Kusunose, Rie Amano, Munehide Matsuhisa, Hiroyuki Daida, Masaaki Ito, Hiroyuki Tsutsui, Mamoru Nanasato, Haruo Kamiya, Yasuko K Bando, Masato Odawara, Hisako Yoshida, Toyoaki Murohara, Masataka Sata, Koichi Node
BACKGROUND: Diabetes is associated closely with an increased risk of cardiovascular events, including diastolic dysfunction and heart failure that leads to a shortening of life expectancy. It is therefore extremely valuable to evaluate the impact of antidiabetic agents on cardiac function. However, the influence of dipeptidyl peptidase 4 inhibitors on cardiac function is controversial and a major matter of clinical concern. We therefore evaluated the effect of sitagliptin on echocardiographic parameters of diastolic function in patients with type 2 diabetes as a sub-analysis of the PROLOGUE study...
May 11, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28489885/visit-to-visit-glycemic-variability-is-a-strong-predictor-of-chronic-obstructive-pulmonary-disease-in-patients-with-type-2-diabetes-mellitus-competing-risk-analysis-using-a-national-cohort-from-the-taiwan-diabetes-study
#9
Hsien-Tsai Chiu, Tsai-Chung Li, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Cheng-Chieh Lin
BACKGROUND: This study aims to examine the association between visit-to-visit glucose variability, which was measured by coefficient of variation (CV) of fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c), and risk of chronic obstructive pulmonary disease (COPD) in a large number of patients with type 2 diabetes with an average follow-up of 7.58 years. METHODS: We conducted a retrospective cohort study on 27,257 patients with type 2 diabetes who participated in the National Diabetes Case Management Program in Taiwan...
2017: PloS One
https://www.readbyqxmd.com/read/28488397/dietary-sodium-intake-relates-to-vascular-health-in-children-with-type-1-diabetes
#10
Jemma Anderson, Jennifer J Couper, Sarah Toome, Christine Mpundu-Kaambwa, Lynne C Giles, Roger Gent, Brian Coppin, Alexia S Peña
BACKGROUND AND OBJECTIVE: Children with type 1 diabetes (T1D) have vascular dysfunction and frequently struggle to adhere to dietary recommendations. Limited data exist for the vascular consequences of poor diet quality in children. We aimed to evaluate the association between dietary components and vascular function in children with T1D. METHODS: Cross-sectional study including 90 children (13.6 [3.5] years, 41 boys) with T1D. They had evaluation of dietary micro and macronutrients (Australian Child and Adolescent Eating Survey), vascular endothelial and smooth muscle function (flow-mediated dilatation and glyceryl trinitrate mediated dilatation [GTN], respectively), clinical and biochemical variables...
May 10, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28488272/pathophysiological-characteristics-of-preproinsulin-specific-cd8-t-cells-in-subjects-with-juvenile-onset-and-adult-onset-type-1-diabetes-a-1-year-follow-up-study
#11
Mahinder Paul, Darshan Badal, Neenu Jacob, Devi Dayal, Rakesh Kumar, Anil Bhansali, Sanjay Kumar Bhadada, Naresh Sachdeva
AIMS/HYPOTHESIS: Among the beta-cell associated antigens, preproinsulin (PPI) has been shown to play a key role in the pathogenesis of type 1 diabetes (T1D). PPI-specific autoreactive CD8+ T cells emerge early during beta-cell destruction and persist in peripheral circulation during diabetes progression. However, the influence of insulin therapy on phenotype of autoreactive CD8+ T cells in T1D including, juvenile-onset T1D (JOT1D), and adult-onset T1D (AOT1D) is not yet known. METHODS: We followed the time course of PPI-specific CD8+ T cells in JOT1D and AOT1D subjects that achieved glycemic control after 1 year of insulin therapy, using major histocompatibility complex-I (MHC-I) dextramers by flow cytometry...
May 10, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28484994/associations-of-blood-glucose-dynamics-with-antihyperglycemic-treatment-and-glycemic-variability-in-type-1-and-type-2-diabetes
#12
K-D Kohnert, P Heinke, L Vogt, P Augstein, A Thomas, E Salzsieder
AIMS: The dynamical structure of glucose fluctuation has largely been disregarded in the contemporary management of diabetes. METHODS: In a retrospective study of patients with diabetes, we evaluated the relationship between glucose dynamics, antihyperglycemic therapy, glucose variability, and glucose exposure, while taking into account potential determinants of the complexity index. We used multiscale entropy (MSE) analysis of continuous glucose monitoring data from 131 subjects with type 1 (n = 18), type 2 diabetes (n = 102), and 11 nondiabetic control subjects...
May 8, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28482944/increased-birth-weight-is-associated-with-altered-gene-expression-in-neonatal-foreskin
#13
L J Reynolds, R I Pollack, R J Charnigo, C S Rashid, A J Stromberg, S Shen, J M O'Brien, K J Pearson
Elevated birth weight is linked to glucose intolerance and obesity health-related complications later in life. No studies have examined if infant birth weight is associated with gene expression markers of obesity and inflammation in a tissue that comes directly from the infant following birth. We evaluated the association between birth weight and gene expression on fetal programming of obesity. Foreskin samples were collected following circumcision, and gene expression analyzed comparing the 15% greatest birth weight infants (n=7) v...
May 9, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28482273/neighborhood-disorder-and-glycemic-control-in-late-adolescents-with-type-1-diabetes
#14
Tara L Queen, Katherine J W Baucom, Ashley C Baker, Daniel Mello, Cynthia A Berg, Deborah J Wiebe
OBJECTIVE: To evaluate the contribution of neighborhood characteristics to treatment adherence and glycemic control in late adolescents with Type 1 diabetes. RESEARCH DESIGN AND METHODS: As part of a larger study, 220 late adolescents with Type 1 diabetes (aged 17.8 ± 0.4 years, 59.6% female, diabetes duration 7.3 ± 3.9 years) were recruited from outpatient pediatric clinics during their senior year of high school. Adolescents completed self-report measures of adherence behaviors and subjective social status, and their HbA1c values were collected during a lab assessment...
April 30, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28472985/age-differences-in-diabetes-related-complications-and-glycemic-control
#15
S M Shamshirgaran, A Mamaghanian, A Aliasgarzadeh, N Aiminisani, M Iranparvar-Alamdari, J Ataie
BACKGROUND: This study aimed to examine the associations of age with the presence of complications and glycemic control in the Northwest of Iran. METHODS: A total of 649 people with diabetes who were >25 years old and had a caring record in diabetes clinics in two Northwestern provinces of Iran during 2014-15, were recruited in this cross-sectional study. General information including demographic, socioeconomic status and lifestyle factors were collected by trained interviewers...
May 4, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28469712/characteristics-and-cardiovascular-complications-of-a-large-cohort-of-adults-diagnosed-with-type-2-diabetes%C3%A2-45%C3%A2-years
#16
Barbara Deconinck, Chantal Mathieu, Katrien Benhalima
BACKGROUND: The aim was to evaluate the characteristics and cardiovascular complications of a large Belgian cohort of adults diagnosed with type 2 diabetes (T2DM) <45 years. METHODS: Retrospective analysis of 886 patients diagnosed with T2DM <45 years and 933 T2DM patients diagnosed at the age between 60 and 70 years. To compare variables between groups, the independent t test or paired t test was used for normally distributed continuous variables, the Mann-Whitney's U-test for non-normally distributed continuous variables and the Chi squared test or McNemar test for categorical variables...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28467785/association-of-lower-body-mass-index-with-increased-glycemic-variability-in-patients-with-newly-diagnosed-type-2-diabetes-a-cross-sectional-study-in-china
#17
Jian Wang, Rengna Yan, Juan Wen, Xiaocen Kong, Huiqin Li, Peihua Zhou, Honghong Zhu, Xiaofei Su, Jianhua Ma
Previous studies have indicated that the pathogenesis of diabetes differs between obese and lean patients. We investigated whether newly diagnosed Chinese diabetic patients with different body mass indices (BMIs) have different glycemic variability, and we assessed the relationship between BMI and glycemic variability. This was a cross-sectional study that included 169 newly diagnosed and drug-naïve type 2 diabetic patients (mean age, 51.33 ± 9.83 years; 110 men). The clinical factors and results of the 75-g oral glucose tolerance test were all recorded...
April 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28466661/dose-unit-establishment-for-a-new-basal-insulin-using-joint-modeling-of-insulin-dose-and-glycemic-response
#18
Yongming Qu, Junxiang Luo, Parag Garhyan, Caryl J Antalis, Annette M Chang, Scott J Jacober
BACKGROUND: For new insulin analogs with properties that vary from human insulin, defining activity in units of human insulin based on glycemic lowering efficacy may be challenging. Here we present a new method that can be used to quantify a unit dose of an experimental insulin when the traditional euglycemic clamp method is not adequate. METHODS: Joint modeling of insulin dose and the glycemic outcome variable hemoglobin A1c (HbA1c), where both were response variables, was used to evaluate insulin unit potency for basal insulin peglispro (BIL)...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28463010/behavioral-patterns-and-associations-with-glucose-control-during-12-week-randomized-free-living-clinical-trial-of-day-and-night-hybrid-closed-loop-insulin-delivery-in-adults-with-type-1-diabetes
#19
Ali Emami, Malgorzata E Willinska, Hood Thabit, Lalantha Leelarathna, Sara Hartnell, Sibylle Dellweg, Carsten Benesch, Julia K Mader, Manuel Holzer, Harald Kojzar, Thomas R Pieber, Sabine Arnolds, Mark L Evans, Roman Hovorka
OBJECTIVES: We evaluated patterns of meal intake, insulin bolus delivery, and fingerstick glucose measurements during hybrid closed-loop and sensor-augmented pump (SAP) therapy, including associations with glucose control. METHODS: Data were retrospectively analyzed from pump-treated adults with type 1 diabetes who underwent, in random order, 12 weeks free-living closed-loop (n = 32) and 12 weeks SAP (n = 33) periods. We quantified daily patterns of main meals, snacks, prandial insulin boluses, correction boluses, and fingerstick glucose measurements by analyzing data recorded on the study glucometer and on study insulin pump...
May 2, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28453522/potential-biological-pathways-linking-type-d-personality-and-poor-health-a-cross-sectional-investigation
#20
Vera K Jandackova, Julian Koenig, Marc N Jarczok, Joachim E Fischer, Julian F Thayer
BACKGROUND: Type-D personality, defined as a combination of high negative affect and high social isolation, has been associated with poor health outcomes. However, pathways underlying this association are largely unknown. We investigated the relationship between Type-D personality and several biological and behavioral pathways including the autonomic nervous system, the immune system, glucose regulation and sleep in a large, apparently healthy sample. METHODS: Data from a total of 646 respondents (age 41...
2017: PloS One
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