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Glycemic variability

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https://www.readbyqxmd.com/read/29322486/dapagliflozin-and-empagliflozin-ameliorate-hepatic-dysfunction-among-chinese-subjects-with-diabetes-in-part-through-glycemic-improvement-a-single-center-retrospective-observational-study
#1
Paul Chi Ho Lee, Yunjuan Gu, Man Yi Yeung, Carol Ho Yi Fong, Yu Cho Woo, Wing Sun Chow, Kathryn Tan, Karen Siu Ling Lam
INTRODUCTION: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) improve hepatic dysfunction, although studies focusing on their underlying mechanisms are lacking, especially ones on dapagliflozin and empagliflozin. Here, we investigated the relationship between amelioration of hepatic dysfunction and improvement in various metabolic parameters among Chinese subjects with type 2 diabetes (T2DM). METHODS: This was a single-center, retrospective, observational study that involved 115 Chinese participants with T2DM treated with either dapagliflozin or empagliflozin for at least 6 months between July 2016 and February 2017...
January 10, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29320884/correlation-between-third-trimester-glycemic-variability-in-non-insulin-dependent-gestational-diabetes-mellitus-and-adverse-pregnancy-and-fetal-outcomes
#2
Wanwadee Sapmee Panyakat, Chayawat Phatihattakorn, Apiradee Sriwijitkamol, Prasert Sunsaneevithayakul, Amprapha Phaophan, Aporn Phichitkanka
BACKGROUND: Gestational diabetes mellitus (GDM) is a pregnancy-related metabolic complication. Despite optimal glycemic control from self-monitoring blood glucose (SMBG) in non-insulin-dependent GDM, variations in pregnancy outcomes persist. Glycemic variability is believed to be a factor that causes adverse pregnancy outcomes. Continuous glucose monitoring system (CGMS) detects interstitial glucose values every 5 minutes, and glycemic variability data from CGMS during the third trimester may be a predictor of fetal birth weight and pregnancy outcomes...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29314138/ovarian-markers-and-irregular-menses-among-women-with-type-1-diabetes-in-the-epidemiology-of-diabetes-interventions-and-complications-study
#3
C Kim, R S Miller, B H Braffett, Y Pan, V L Arends, A K Saenger, A Barnie, A V Sarma
OBJECTIVE: Women with type 1 diabetes have increased risk of infertility compared to women without diabetes even after adjustment for irregular menses, but etiologies are incompletely understood. Our aim was to examine the prevalence of abnormalities in ovarian markers consistent with polycystic ovary syndrome in women with type 1 diabetes and associations with irregular menses and diabetes-specific variables. DESIGN, PATIENTS, AND MEASUREMENTS: We conducted a secondary analysis of women in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC), a randomized trial and observational follow-up of intensive insulin therapy for type 1 diabetes...
January 4, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29308705/predictors-of-empowerment-in-individuals-with-type-2-diabetes-mellitus
#4
Hamdiye Arda Sürücü, Dilek Büyükkaya Besen
INTRODUCTION: Type 2 diabetes is a chronic, progressive disease that has reached pandemic proportions. In Turkey, the frequency of diabetes in individuals aged 20 years or older has been reported to be 13.7% compared with the worldwide prevalence of 8.5%. Empowerment has been correlated with improvement in diabetic self-management capabilities and glycemic control. The purpose of this study was to examine predictors of "empowerment" in individuals with type 2 diabetes from Turkey. METHOD: This was a secondary analysis with a cross-sectional correlation design using stepwise linear regression to evaluate previously collected data from 220 type 2 diabetic individuals in Turkey from January through July 2014...
December 1, 2017: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/29307112/the-influences-of-chromium-supplementation-on-glycemic-control-markers-of-cardio-metabolic-risk-and-oxidative-stress-in-infertile-polycystic-ovary-syndrome-women-candidate-for-in-vitro-fertilization-a-randomized-double-blind-placebo-controlled-trial
#5
Mehri Jamilian, Shahrzad Zadeh Modarres, Mehrnush Amiri Siavashani, Maryam Karimi, Alireza Mafi, Vahidreza Ostadmohammadi, Zatollah Asemi
This study was carried out to investigate the effects of chromium intake on glycemic control, markers of cardio-metabolic risk, and oxidative stress in infertile polycystic ovary syndrome (PCOS) women candidate for in vitro fertilization (IVF). This randomized double-blind, placebo-controlled trial was done among 40 subjects with infertile PCOS candidate for IVF, aged 18-40 years old. Individuals were randomly allocated into two groups to take either 200 μg/day of chromium (n = 20) or placebo (n = 20) for 8 weeks...
January 6, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29305827/influence-of-socioeconomic-and-psychological-factors-in-glycemic-control-in-young-children-with-type-1-diabetes-mellitus
#6
Carlos Jefferson do Nascimento Andrade, Crésio de Aragão Dantas Alves
OBJECTIVE: To evaluate the influence of socioeconomic and psychological factors on glycemic control in young children with type 1 diabetes mellitus. METHODS: This was a cross-sectional study assessing prepubertal children with type 1 diabetes mellitus. The authors analyzed the socioeconomic status using the Brazil Economic Classification Criterion (Critério de Classificação Econômica Brasil [CCEB]) and psychological conditions through the Brazilian version of the Problem Areas in Diabetes, associated with glycemic control, measured by glycated hemoglobin (HbA1c)...
January 3, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29305569/emergence-of-insulin-resistance-following-empirical-glibenclamide-therapy-a-case-report-of-neonatal-diabetes-with-a-recessive-ins-gene-mutation
#7
Melek Yildiz, Teoman Akcay, Banu Aydin, Abdurrahman Akgun, Beyza Belde Dogan, Elisa De Franco, Sian Ellard, Hasan Onal
BACKGROUND: As KATP channel mutations are the most common cause of neonatal diabetes mellitus (NDM) and patients with these mutations can be treated with oral sulfonylureas, empiric therapy is a common practice for NDM patients. CASE PRESENTATION: A non-syndromic, small for gestational age baby born to first-degree consanguineous parents was diagnosed with NDM. Because of hypo- and hyperglycemic episodes and variability in insulin requirement, we initiated a trial of glibenclamide, with a presumptive diagnosis of NDM caused by a KATP channel mutation...
January 6, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29303370/the-effects-of-subcutaneous-insulin-infusion-versus-multiple-insulin-injections-on-glucose-variability-in-young-adults-with-type-1-diabetes-the-2-year-follow-up-of-the-observational-metro-study
#8
Maria Ida Maiorino, Giuseppe Bellastella, Ofelia Casciano, Paolo Cirillo, Vittorio Simeon, Paolo Chiodini, Michela Petrizzo, Maurizio Gicchino, Ornella Romano, Paola Caruso, Dario Giugliano, Katherine Esposito
BACKGROUND: Type 1 diabetic patients have high instability of daily glucose levels. The aim of this study was to evaluate the long-term effects of continuous subcutaneous insulin infusion (CSII) therapy, compared with multiple daily injections of insulin (MDI), on glucose variability, in young type 1 diabetic patients transitioned to the adult diabetes care. METHODS: Patients aged 18-30 years and considered eligible for insulin pump therapy were included in the study...
January 5, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29301456/can-we-stratify-the-risk-for-insulin-need-in-women-diagnosed-early-with-gestational-diabetes-by-fasting-blood-glucose
#9
Ana C R L A Souza, Rafaela A Costa, Cristiane F Paganoti, Agatha S Rodrigues, Marcelo Zugaib, Eran Hadar, Moshe Hod, Rossana P V Francisco
OBJECTIVE: To evaluate risk factors and propose a model for the prediction of insulin requirement during the treatment of early-diagnosed gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: Retrospective cohort analysis of all pregnant women who were diagnosed with GDM by abnormal fasting blood glucose at the first prenatal visit. According to the requirement for insulin therapy to achieve good glycemic control (insulin or diet group), women were compared regarding clinical and laboratory variables...
January 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29285445/comparison-of-two-protocols-in-the-management-of-glucocorticoid-induced-hyperglycemia-among-hospitalized-patients
#10
Om J Lakhani, Surender Kumar, Sudhir Tripathi, Mitali Desai, Chandani Seth
Context: There is limited literature focusing on the management of glucocorticoid-induced hyperglycemia (GCIH). Aims: The primary objective was to compare the mean blood glucose between the experimental group (new protocol) and the control group (standard protocol) in the management of GCIH. The secondary objective was to compare other parameters of glycemic efficacy, variability, and safety parameters. Methods: This was a randomized, open-labeled, parallel arm trial...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29280058/ethnicity-does-not-influence-glycemic-outcomes-or-diabetes-remission-after-sleeve-gastrectomy-or-gastric-bypass-in-a-multiethnic-asian-cohort
#11
Phong Ching Lee, Kwang Wei Tham, Sonali Ganguly, Hong Chang Tan, Alvin Kim Hock Eng, John B Dixon
BACKGROUND: In Asia, metabolic-bariatric surgery (MBS) rates have grown rapidly in parallel with rising prevalence of obesity and type 2 diabetes (T2D). OBJECTIVE: The objective of this study was to identify factors that influence glycemic outcomes and diabetes remission 12 months after sleeve gastrectomy (SG) or gastric bypass (GB) in a multiethnic Asian cohort. SETTING: The study's setting was in a tertiary hospital in Singapore. METHODS: Data from 145 T2D patients who had SG (37%) or GB (63%) and at least 1-year follow-up were analyzed...
December 26, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29279270/prevalence-of-thyroid-disorders-in-north-indian-type-2-diabetic-subjects-a-cross-sectional-study
#12
Maaz Ozair, Saba Noor, Alok Raghav, Sheelu Shafiq Siddiqi, Anjum Mirza Chugtai, Jamal Ahmad
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major health burden worldwide with many patients encountering thyroid dysfunction later in their life. Various studies have found that diabetes and thyroid disorders mutually influence each other and both disorders tend to coexists. However, the prevalence of thyroid dysfunction and associated clinical variables in these patients has not been investigated. OBJECTIVES: The study aimed at determining the incidence and prevalence of thyroid dysfunction in patients with T2DM in relation to age, sex, metabolic syndrome and other co-morbid conditions...
December 20, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29278829/efficacy-of-maternal-and-biological-parameters-at-the-time-of-diagnosis-of-gestational-diabetes-mellitus-in-predicting-neonatal-morbidity
#13
Guillaume Ducarme, François Desroys Du Roure, Aurélie Le Thuaut, Joséphine Grange, Jérôme Dimet, Ingrid Crepin-Delcourt
OBJECTIVE: Gestational diabetes mellitus (GDM) is independently associated with an increased risk of maternal-fetal complications. Improved glycemic control allows reducing perinatal morbidity and mortality and, specifically, the risk of macrosomia and shoulder dystocia which are the most common complications associated with GDM. Nonetheless, a need for early antenatal predictor of neonatal morbidity in women suffering from GDM is required. The objective of the study was to evaluate the efficacy of different maternal, biological, and antenatal parameters at the time of diagnosis of GDM or perinatal variables as predictors of neonatal morbidity...
December 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29278712/a-national-survey-on-the-efficacy-and-safety-of-continuous-subcutaneous-insulin-infusion-in-patients-with-type-1-diabetes-in-spain
#14
P Beato-Víbora, Ana Chico-Ballesteros, Marga Giménez, Raquel Guerrero-Vázquez, Raquel Barrio-Castellanos, María José Goñi-Iriarte, Gonzalo Díaz-Soto, Juan Francisco Merino-Torres, Jesús Moreno-Fernández, María Asunción Martínez-Brocca
AIMS: To assess safety and benefits of continuous subcutaneous insulin infusion (CSII) therapy in a cohort of type 1 diabetes patients in Spain. METHODS: A web-based national registry was created by the Working Group of the Spanish Diabetes Association. All patients on CSII being followed at selected referral centers were included. A cross-sectional analysis was performed. RESULTS: A total of 1,275 patients were included. Data completion for patients on CSII was 67 ± 32%...
December 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29278711/self-efficacy-self-care-and-glycemic-control-in-saudi-arabian-patients-with-type-2-diabetes-mellitus-a-cross-sectional-survey
#15
Ahmad M J Saad, Zeina M H Younes, Hafez Ahmed, Jason A Brown, Rafat M Al Owesie, Ahmed A K Hassoun
AIMS: To determine the prevalence of diabetes self-care activities among type 2 diabetes patients and examine the association between socio-demographic and clinical parameters, diabetes self-care activities, and glycemic control among type 2 diabetes patients. METHODS: A cross sectional study was conducted among patients with diabetes (n=123) at the Sultan Bin Abdulaziz Humanitarian City (SBAHC). A regression model was used to examine the variables that predicted glycemic control...
December 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29277316/the-flexible-lifestyle-empowering-change-flex-intervention-for-self-management-in-adolescents-with-type-1-diabetes-trial-design-and-baseline-characteristics
#16
Jessica C Kichler, Michael Seid, Jamie Crandell, David M Maahs, Franziska K Bishop, Kimberly A Driscoll, Debra Standiford, Christine M Hunter, Elizabeth Mayer-Davis
The Flexible Lifestyle Empowering Change (FLEX) Intervention Study is a multi-site randomized controlled trial to test the efficacy of an adaptive behavioral intervention to promote self-management for youth with type 1 diabetes mellitus (T1D). This paper details FLEX design, demographic characteristics of the sample, and outcome variables at baseline. Participants were randomized to either an intervention or control arm after their baseline standardized measurement visit. Baseline data for the primary (glycemic levels) and secondary outcome variables (e...
December 22, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29276347/model-fusion-based-online-glucose-concentration-predictions-in-people-with-type-1-diabetes
#17
Xia Yu, Kamuran Turksoy, Mudassir Rashid, Jianyuan Feng, Nicole Frantz, Iman Hajizadeh, Sediqeh Samadi, Mert Sevil, Caterina Lazaro, Zacharie Maloney, Elizabeth Littlejohn, Laurie Quinn, Ali Cinar
Accurate predictions of glucose concentrations are necessary to develop an artificial pancreas (AP) system for people with type 1 diabetes (T1D). In this work, a novel glucose forecasting paradigm based on a model fusion strategy is developed to accurately characterize the variability and transient dynamics of glycemic measurements. To this end, four different adaptive filters and a fusion mechanism are proposed for use in the online prediction of future glucose trajectories. The filter fusion mechanism is developed based on various prediction performance indexes to guide the overall output of the forecasting paradigm...
February 2018: Control Engineering Practice
https://www.readbyqxmd.com/read/29274892/role-of-resistant-starch-on-diabetes-risk-factors-in-people-with-prediabetes-design-conduct-and-baseline-results-of-the-starch-trial
#18
Kara L Marlatt, Ursula A White, Robbie A Beyl, Courtney M Peterson, Corby K Martin, Maria L Marco, Michael J Keenan, Roy J Martin, Kayanush J Aryana, Eric Ravussin
Dietary resistant starch (RS) might alter gastrointestinal tract function in a manner that improves human health, particularly among adults at risk for diabetes. Here, we report the design and baseline results (with emphasis on race differences) from the STARCH trial, the first comprehensive metabolic phenotyping of people with prediabetes enrolled in a randomized clinical trial testing the effect of RS on risk factors for diabetes. Overweight/obese participants (BMI≥27kg/m2 and weight≤143kg), age 35-75y, with confirmed prediabetes were eligible...
December 21, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29273427/patients-lacking-glycemic-control-place-more-burdens-on-health-services-with-the-use-of-medications
#19
Ana Márcia Tomé Camargos, Ana Carolina Oliveira Gonçalves, Maurílio Sousa Cazarin, Cristina Sanches, Leonardo Régis Leira Pereira, André Oliveira Baldoni
INTRODUCTION: DM spending in the world is high, and Brazilian studies of public spending caused by DM are scarce. OBJECTIVE: To estimate the annual direct cost for the municipal health sphere, related to DM2 treatment, in patients with and without glycemic control. METHOD: A cross-sectional study carried out in a city in the interior of Minas Gerais state, with patients with DM2, being municipal PHS users. Data were collected from the computerized system of the municipality and patient records, and analyzed using the IBM SPSS v...
December 17, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29261679/distinct-impacts-of-sleep-disordered-breathing-on-glycemic-variability-in-patients-with-and-without-diabetes-mellitus
#20
Kei Nakata, Takayuki Miki, Masaya Tanno, Hirofumi Ohnishi, Toshiyuki Yano, Atsuko Muranaka, Tatsuya Sato, Hiroto Oshima, Yuki Tatekoshi, Masashi Mizuno, Koki Abe, Tetsuji Miura
BACKGROUND: Sleep-disordered breathing (SDB) is highly prevalent in patients with diabetes mellitus (DM) and heart failure (HF) and contributes to poor cardiovascular outcomes. Enlarged glycemic variability (GV) is a risk factor of cardiac events independently of average blood glucose level, but the influence of SDB on GV is uncertain. In this study, we examined whether the impact of SDB on GV is modified by the presence of DM with or without HF. METHODS AND RESULTS: Two hundred three patients (67...
2017: PloS One
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