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Glycemic variability

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https://www.readbyqxmd.com/read/29782842/paraoxonase-1-pon1-l55m-among-common-variants-in-the-coding-region-of-the-paraoxonase-gene-family-may-contribute-to-the-glycemic-control-in-type-2-diabetes
#1
Abdolkarim Mahrooz, Mohammad Bagher Hashemi-Soteh, Masoud Heydari, Ruzbeh Boorank, Fatemeh Ramazani, Ali Mahmoudi, Anvarsadat Kianmehr, Ahad Alizadeh
OBJECTIVE: Genome studies have shown that the genes encoding paraoxonase 1 (PON1) and PON2 are associated with glucose metabolism. The goal of this study was to simultaneously evaluate the association between functional variants in PON1 and PON2 genes and susceptibility for type 2 diabetes (T2D) and determine whether they can affect glycemic control. METHODS: We performed a case-control study with 145 newly diagnosed patients with T2D and 148 controls. The common variants including PON1-Q192R, PON1-L55M and PON2-S311C were genotyped by PCR-based RFLP...
May 18, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29782387/income-relates-to-adherence-in-youth-with-type-1-diabetes-through-parenting-constructs
#2
Dexter M Thomas, Leah M Lipsky, Aiyi Liu, Tonja R Nansel
OBJECTIVE: Informed by the family stress and family investment models, this study investigated whether income is indirectly related to adherence and glycemic control through parenting constructs among youth with type 1 diabetes (TID). METHODS: Youth and their families (n = 390) from 4 geographically dispersed pediatric endocrinology clinics in the United States were participants in a multisite clinical trial from 2006 to 2009 examining the efficacy of a clinic-integrated behavioral intervention targeting family disease management for youth with TID...
May 17, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29777522/impact-of-insulin-degludec-in-hospitalized-patients-with-and-without-type-2-diabetes-requiring-parenteral-enteral-nutrition-an-observational-study
#3
Giuseppe Fatati, Agnese Di Donato, Ilenia Grandone, Pina Menicocci, Eva Mirri, Giuseppe Prosperini, Marco Scardapane, Maria Chiara Rossi, Mariangela Palazzi
INTRODUCTION: Hyperglycemia in inpatients is a major problem, especially when nutritional support is required. This study aims to assess the impact of treatment with insulin degludec (IDeg) on mean blood glucose (BG) and glycemic variability in noncritical hospitalized patients with and without type 2 diabetes (T2DM) receiving enteral and/or parenteral nutrition (EN, PN). METHODS: Mean BG and glycemic variability from admission up to 7 days of hospitalization were evaluated in consecutive cases with and without T2DM...
May 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29776663/barriers-and-facilitators-to-diabetes-self-management-in-a-primary-care-setting-patient-perspectives
#4
Rahul Khairnar, Khalid M Kamal, Vincent Giannetti, Nilanjana Dwibedi, Jamie McConaha
BACKGROUND: Diabetes self-management (DSM) is a key element in the overall management of type-2 diabetes (T2DM). Identifying barriers and facilitators to DSM and addressing them is a critical step in achieving improved health outcomes in this population. OBJECTIVE: To assess patient reported barriers and facilitators to self-management of T2DM in a primary care setting. METHODS: This cross sectional study combined patient survey data with electronic medical record (EMR) data...
May 9, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29775127/glycemic-control-and-its-associated-factors-among-diabetes-mellitus-patients-at-ayder-comprehensive-specialized-hospital-mekelle-ethiopia
#5
Seifu Mideksa, Sintayehu Ambachew, Belete Biadgo, Habtamu Wondifraw Baynes
Diabetes is one of the largest health emergencies of the twenty-first century and it is increasing with alarming rate throughout the world. Glycemic Control in diabetes patients is an important issue in minimizing diabetes related complications and deaths. Institution based comparative cross-sectional study was conducted from March to April, 2017. Glycated Hemoglobin A1c and biochemical profiles were determined using Huma Meter A1c and ABX PENTRA 400 clinical chemistry analyzer. Independent t-test to compare groups, bivariate and multi variable logistic regression analysis were used...
May 18, 2018: Adipocyte
https://www.readbyqxmd.com/read/29769806/paediatric-type-1-diabetes-2018-clinical-and-research-insights
#6
Stephen J Zborovski, Farid H Mahmud
The management of children and adolescents with type 1 diabetes continues to progress as clinical and technological innovations enter into practice. Variability in glucose readings can present a significant challenge for care providers, patients and families alike and recent research demonstrates that insulin selection and site-related lipohypertrophy can significantly influence blood glucose levels. New technology aims to improve both glycemic control and quality of life. New insulin analogues have been developed and insulin pumps and continuous glucose monitoring systems continue to evolve toward a fully closed-loop system...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29760928/aneurysmal-subarachnoid-hemorrhage-intensive-care-for-improving-neurological-outcome
#7
REVIEW
Tomoya Okazaki, Yasuhiro Kuroda
Background: Aneurysmal subarachnoid hemorrhage is a life-threatening disease requiring neurocritical care. Delayed cerebral ischemia is a well-known complication that contributes to unfavorable neurological outcomes. Cerebral vasospasm has been thought to be the main cause of delayed cerebral ischemia, and although several studies were able to decrease cerebral vasospasm, none showed improved neurological outcomes. Our target is not cerebral vasospasm but improving neurological outcomes...
2018: Journal of Intensive Care
https://www.readbyqxmd.com/read/29760917/factors-associated-with-glycemic-status-and-ability-to-adapt-to-changing-demands-in-people-with-and-without-type-2-diabetes-mellitus-a-cross-sectional-study
#8
Bertha Cecilia Salazar-González, Esther C Gallegos-Cabriales, Alicia Rivera-Castillo, Arnulfo González-Cantú, Marco Vinicio Gómez-Meza, Jesús Zacarías Villarreal-Pérez
Objectives: Type 2 diabetes mellitus studies focus on metabolic indicators and different self-reported lifestyle or care behaviors. Self-reported instruments involve conscious process therefore responses might not reflect reality. Meanwhile implicit responses involve automatic, unconscious processes underlying social judgments and behavior. No studies have explored the combined influence of both metabolic indicators and implicit responses on lifestyle practices in type 2 diabetes mellitus patients...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29753996/risk-factors-for-diabetic-foot-ulcer-recurrence-a-prospective-2-year-follow-up-study-in-egypt
#9
Walaa A Khalifa
OBJECTIVES: To determine the frequency of diabetic foot ulcer recurrence and its potential risk factors. METHODS: This study included 93 patients with type 2 diabetes and followed for 2 years after primary healed foot ulceration. Demographic, diabetes related, comorbid and ulcer related variables were investigated as risk factors. Multiple logistic regression analysis was used to identify independent risk factors. RESULTS: 61.3% of patients had recurrent ulcers particularly in the forefoot (33...
December 28, 2017: Foot
https://www.readbyqxmd.com/read/29753585/high-sensitivity-c-reactive-protein-low-grade-systemic-inflammation-and-type-2-diabetes-mellitus-a-two-sample-mendelian-randomization-study
#10
R Noordam, C H Oudt, M M Bos, R A J Smit, D van Heemst
BACKGROUND AND AIMS: The role of inflammation in type 2 diabetes mellitus (T2D) remains unclear. We investigated the associations of high sensitivity C-reactive protein (hsCRP) concentration with T2D and glycemic traits using two-sample Mendelian Randomization. METHODS AND RESULTS: We used publically available summary-statistics data from genome-wide association studies on T2D (DIAGRAM: 12 171 cases; 56 862 controls) and glycemic traits (MAGIC: 46 186 participants without diabetes mellitus)...
March 26, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29749032/comparison-between-preprandial-versus-postprandial-insulin-aspart-administration-in-patients-with-type-1-diabetes-benefiting-from-insulin-pump-and-real-time-continuous-glucose-monitoring
#11
Philippe Thuillier, Emmanuel Sonnet, Zarrin Alavi, Nathalie Roudaut, Emmanuel Nowak, Angélina Dion, Véronique Kerlan
BACKGROUND: The objective was to compare glycemic control between pre- and post-prandial bolus administration (15min before (PRE) or immediately after the meal (POST)) in patients with type 1 diabetes using insulin pump and real time continuous glucose monitoring (RT-CGM). METHODS: Between September 2015 and February 2016, a single-centre, open randomized, two-way crossover study of patients on bolus insulin aspart administration was conducted during two 14-days periods and according to two administration regimen schedules(...
May 10, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29745337/factors-associated-with-poor-hemoglobin-a1c-control-in-patients-with-type-2-diabetes
#12
Salam Alqudah, Anan S Jarab, Eman A Alefishat, Fadia Mayyas, Maher Khdour, Sharrel Pinto
Background The limited implementation of clinical pharmacy service programs and the lack of studies identifying barriers to achieve blood glucose control have all attributed to the increased proportion of type 2 diabetes patients who have poor glycemic control in Jordan. Objective To explore factors associated with higher HbA1c in patients with type 2 diabetes in Jordan. Method Variables including socio-demographics, disease and treatment factors were collected from171 patients with type2 diabetes at an outpatient diabetes clinic in Amman...
May 10, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29744819/comparison-of-glycemic-variability-in-chinese-t2dm-patients-treated-with-exenatide-or-insulin-glargine-a-randomized-controlled-trial
#13
Ting-Ting Yin, Yan Bi, Ping Li, Shan-Mei Shen, Xiao-Lu Xiong, Li-Jun Gao, Can Jiang, Yan Wang, Wen-Huan Feng, Da-Long Zhu
INTRODUCTION: Increasing the frequency of blood glucose monitoring aids the evaluation of glycemic variability and blood glucose control by antidiabetic drugs. It remains unclear, however, whether GLP-1 receptor agonists or basal insulin has a better effect on glycemic variability in type 2 diabetes mellitus (T2DM) patients who are inadequately controlled by metformin. We used a continuous glucose monitoring system (CGMS) to compare patients on a GLP-1 receptor agonist with patients on basal insulin in terms of glycemic variability...
May 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29744272/antidiabetic-activity-of-mefloquine-via-glp-1-receptor-modulation-against-stz-na-induced-diabetes-in-albino-wistar-rats
#14
Rajnish Kumar Yadav, Jitendra K Rawat, Swetlana Gautam, Manjari Singh, Manish Kumar, Mohd Nazam Ansari, Subhadeep Roy, Abdulaziz S Saeedan, Gaurav Kaithwas
Mefloquine was retrieved as a glucagon -like peptide-1 receptor agonist and, therefore, evaluated for its antidiabetic potential against non-insulin-dependent diabetes mellitus (NIDDM) in experimental animals. NIDDM was induced by single intraperitoneal injection of streptozotocin and nicotinamide (60 + 110 mg/kg) in albino wistar rats. The experimental animals were scrutinised for electrocardiographic (ECG) and heart rate variability (HRV) factors to study the autonomic dysfunction along with blood glucose, serum insulin, and liver glycogen levels for glycemic control...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29737202/health-care-costs-hospital-admissions-and-glycemic-control-using-a-standalone-real-time-continuous-glucose-monitoring-system-in-commercially-insured-patients-with-type-1-diabetes
#15
Max Gill, Cyrus Zhu, Mona Shah, Harmeet Chhabra
BACKGROUND: Studies comparing standalone real-time continuous glucose monitoring (rtCGM) to self-monitoring of blood glucose (SMBG) in patients with type 1 diabetes mellitus (T1DM) have found that rtCGM is associated with lower glycated hemoglobin (A1C) levels, yet does not increase the risk of severe hypoglycemia. However, little is known about the relationship between rtCGM and health care costs and utilization. The objective of this study was to compare health care spending, hospital admissions, and A1C levels of patients using rtCGM to that of patients not using rtCGM...
May 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29728302/clinically-significant-cognitive-impairment-in-older-adults-with-type-1-diabetes
#16
Naomi S Chaytor, Celestina Barbosa-Leiker, Christopher M Ryan, Laura T Germine, Irl B Hirsch, Ruth S Weinstock
AIMS: Little is known about cognition in older adults with type 1 diabetes. The aim of this study was to identify correlates of clinically significant cognitive impairment. METHODS: Neuropsychological, diabetes-related and glycemic (HbA1c, Continuous Glucose Monitoring; CGM) data were collected from 201 older adults (≥60 years) with longstanding type 1 diabetes. RESULTS: Clinically significant cognitive impairment (≥2 cognitive tests ≥1...
April 14, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29725320/cardiovascular-autonomic-neuropathy-and-glucose-variability-in-patients-with-type-1-diabetes-is-there-an-association
#17
Szabolcs Nyiraty, Fruzsina Pesei, Andrea Orosz, Sara Coluzzi, Orsolya Eszter Vági, Csaba Lengyel, György Ábrahám, Simona Frontoni, Peter Kempler, Tamás Várkonyi
Introduction: The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect GV. Patients and methods: Twenty type 1 diabetic patients were involved (age: 39.5 ± 3.4 years, duration of diabetes: 17.5 ± 2.5 years; HbA1c: 8...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29724703/using-digital-health-technologies-to-understand-the-association-between-movement-behaviors-and-interstitial-glucose-exploratory-analysis
#18
Andrew P Kingsnorth, Maxine E Whelan, James P Sanders, Lauren B Sherar, Dale W Esliger
BACKGROUND: Acute reductions in postprandial glucose excursions because of movement behaviors have been demonstrated in experimental studies but less so in free-living settings. OBJECTIVE: The objective of this study was to explore the nature of the acute stimulus-response model between accelerometer-assessed physical activity, sedentary time, and glucose variability over 13 days in nondiabetic adults. METHODS: This study measured physical activity, sedentary time, and interstitial glucose continuously over 13 days in 29 participants (mean age in years: 44...
May 3, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29716762/plasma-zinc-in-institutionalized-elderly-individuals-relation-with-immune-and-cardiometabolic-biomarkers
#19
Márcia Cristina Sales, Larissa Praça de Oliveira, Natalia Louise de Araújo Cabral, Sara Estéfani Soares de Sousa, Maria das Graças Almeida, Telma Maria Araújo Moura Lemos, Clélia de Oliveira Lyra, Kenio Costa de Lima, Karine Cavalcanti Mauricio Sena-Evangelista, Lucia de Fatima Campos Pedrosa
Changes in zinc metabolism caused by aging and the institutionalization process may contribute to zinc deficiency in elderly individuals. Hypozincemia results in changes in glycemic, lipid, and inflammatory profiles. The aim of this study was to evaluate plasma zinc concentrations and their relationships with sociodemographic, dietary, inflammatory, and cardiometabolic biomarkers in institutionalized elderly individuals. A cross-sectional study was carried out including 255 elderly adults living in nursing homes...
April 24, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29708297/sleep-habits-in-adolescents-with-type-1-diabetes-variability-in-sleep-duration-linked-with-glycemic-control
#20
Niral J Patel, Kimberly L Savin, Sachini N Kahanda, Beth A Malow, Lauren A Williams, Gray Lochbihler, Sarah S Jaser
OBJECTIVE: To describe adolescents' sleep on school and weekend nights using multiple methods, and to examine the links between sleep variability, quality and duration with diabetes indicators. METHODS: Adolescents with type 1 diabetes (N=65, mean age=15.0, 52.3% female, mean HbA1c=8.9% or 74 mmol/mol) wore an actigraph and kept daily diaries recording sleep, activities, and blood glucose monitoring (BGM) habits for at least 7 days. Average daily BGM and blood glucose levels (BG) were obtained through glucometer downloads...
April 30, 2018: Pediatric Diabetes
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