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https://www.readbyqxmd.com/read/28740796/goldilocks-mastectomy-a-safe-bridge-to-implant-based-breast-reconstruction-in-the-morbidly-obese
#1
Jean-Claude Schwartz
BACKGROUND: Reconstructive surgeons are encountering an increasing number of obese women requiring postmastectomy reconstruction. These patients are poor candidates for autologous and prosthetic-based reconstructions as they have a high rate of reconstructive failure, surgical complications, and poor aesthetic outcomes. We demonstrate here the utility of the previously described Goldilocks mastectomy with free nipple grafts as a safe bridge to second stage implant-based breast reconstruction...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28738899/a-rare-manifestation-of-burns-after-lightning-strike-in-rural-ghana-a-case-report
#2
Paschal Awingura Apanga, John Atigiba Azumah, Joseph Bayewala Yiranbon
BACKGROUND: Lightning is a natural phenomenon that mostly affects countries in the tropical and subtropical regions of the globe, including Ghana. Lightning strikes pose a global public health issue. Although strikes to humans are uncommon, it is associated with high morbidity and mortality. CASE PRESENTATION: We present a case of a 10-year-old Ghanaian girl who got second-degree burns after being struck by lightning. She was put on an intravenous broad-spectrum antibiotic (ceftriaxone), Ringer's lactate, and her burns were dressed with sterile gauze impregnated with Vaseline (petroleum jelly) and silver sulfadiazine ointment...
July 25, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28738858/erythema-nodosum-masking-nephrogenic-systemic-fibrosis-as-initial-skin-manifestation
#3
Kar Wah Fuah, Christopher Thiam Seong Lim
BACKGROUND: Nephrogenic systemic fibrosis (NSF) is a complication of the gadolinium-based contrast agent used in imaging studies. It is typically characterised by hard, erythematous and indurated skin plaques with surrounding subcutaneous oedema. Distinct papules and subcutaneous nodules can also be seen. Fibrocytes in NSF are immunohistochemically positive for CD34. CASE PRESENTATION: We present a case of NSF occurred after gadolinium exposure in which the initial presentation mimics an erythema nodosum (EN)-like picture...
July 24, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28737529/observation-about-open-surgical-release-of-posttraumatic-elbow-contracture-in-children-and-adolescents
#4
Daniele Coraci, Valter Santilli, Silvia Giovannini, Luca Padua
No abstract text is available yet for this article.
July 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28736191/clinical-histological-and-ultrasound-follow-up-of-breast-reconstruction-with-one-stage-muscle-sparing-wrap-technique-a-single-center-experience
#5
Maria Giuseppina Onesti, Michele Maruccia, Giuseppe Di Taranto, Antonio Albano, Giuseppe Soda, Laura Ballesio, Nicolò Scuderi
BACKGROUND: Prepectoral implant placement and complete coverage with porcine acellular matrix after mastectomy is a new concept in breast surgery presented in few cases in the literature. This paper aimed to present our single-center experience in one-stage breast reconstruction muscle-sparing "wrap" technique by evaluating clinical and aesthetic outcomes, ultrasound and histological examination, and patient quality of life. METHODS: From January 2014 to January 2017, 52 patients (40 unilateral, 12 bilateral) underwent one-stage muscle-sparing breast reconstructions with Braxon(®) acellular dermal matrix and implant...
June 29, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28736162/-skin-engineering-for-severe-burns
#6
J-J Lataillade, B Magne, E Bey, T Leclerc, M Trouillas
Severe burned patients need definitive and efficient wound coverage. Outcome of massive burns has been improved by using cultured epithelial autografts (CEA). Despite fragility, percentages of success take, cost of treatment and long-term tendency to contracture, this surgical technique has been developed in few burn centres. First improvements were to combine CEA and dermis-like substitute. Cultured skin substitutes provide earlier skin closure and satisfying functional result. These methods have been used successfully in massive burns...
July 20, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28734537/total-elbow-arthroplasty-for-primary-osteoarthritis
#7
Bradley S Schoch, Jean-David Werthel, Joaquín Sánchez-Sotelo, Bernard F Morrey, Mark Morrey
BACKGROUND: Primary osteoarthritis of the elbow is a less common indication for total elbow arthroplasty (TEA). Higher complication rates in younger, active patients may offset short-term improvements in pain and function. The purpose of this study was to determine pain relief, functional outcomes, complications, and survival of TEA in this population. METHODS: Between 1984 and 2011, 20 consecutive TEAs were performed for primary elbow osteoarthritis. Two patients died before the 2-year follow-up...
August 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28733338/early-and-lethal-neurodegeneration-with-myasthenic-and-myopathic-features-a-new-alg14-cdg
#8
David C Schorling, Simone Rost, Dirk J Lefeber, Lauren Brady, Clemens R Müller, Rudolf Korinthenberg, Mark Tarnopolsky, Carsten G Bönnemann, Richard J Rodenburg, Marianna Bugiani, Maria Beytia, Marcus Krüger, Marjo van der Knaap, Jan Kirschner
OBJECTIVE: To describe the presentation and identify the cause of a new clinical phenotype, characterized by early severe neurodegeneration with myopathic and myasthenic features. METHODS: This case study of 5 patients from 3 families includes clinical phenotype, serial MRI, electrophysiologic testing, muscle biopsy, and full autopsy. Genetic workup included whole exome sequencing and segregation analysis of the likely causal mutation. RESULTS: All 5 patients showed severe muscular hypotonia, progressive cerebral atrophy, and therapy-refractory epilepsy...
July 21, 2017: Neurology
https://www.readbyqxmd.com/read/28732844/efficacy-and-safety-of-collagenase-treatment-for-dupuytren-s-disease-2-year-follow-up-results
#9
A Van Beeck, M Van den Broek, M Michielsen, K Didden, K Vuylsteke, F Verstreken
Dupuytren's contracture is a common hand problem that affects the palmar fascia. Several treatment options exist, but none are curative and recurrence is common. Bacterial collagenase has recently been proven beneficial for treating Dupuytren's disease, cleaving the collagen fibers at different sites, with weakening and eventually rupture of the fibrous cords after manipulation. An independent prospective follow-up study was organized on 87 patients, treated with one or more collagenase injections. Inclusion criteria were a contracture of at least 20° at the metacarpophalangeal (MCP) or the proximal interphalangeal (PIP) joint...
July 18, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28732843/preliminary-results-with-non-centrifuged-autologous-fat-graft-and-percutaneous-aponeurotomy-for-treating-dupuytren-s-disease
#10
U Tuncel, A Kurt, M Gumus, O Aydogdu, N Güzel, O Demir
The aim of this study was to describe our experience with treating Dupuytren's disease using needle aponeurotomy and non-centrifuged autologous fat grafting. The study included 17 patients (18 hands). Patients were treated with needle aponeurotomy and non-centrifuged autologous fat graft under general anesthesia. The fat grafts were injected into the surgical area so as to stay in contact with the operated site. An extension splint was used for 1 week postoperatively and the patients received hand therapy for 3 weeks...
July 18, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28730530/spastic-paretic-hemifacial-contracture-related-to-multiple-sclerosis-a-rare-and-under-recognized-entity
#11
Sophie Fastré, Philippe Hanson, Frédéric London
We describe an additional case of spastic paretic hemifacial contracture, an uncommon condition characterized by sustained unilateral contraction of the facial muscles associated with mild ipsilateral facial paresis. This entity has only rarely been associated with multiple sclerosis (MS) and can be mistaken for hemifacial spasm. Early consideration of MS in the differential diagnosis of young patients admitted with these symptoms is essential.
July 20, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28730331/-early-functional-passive-mobilization-of-flexor-tendon-injuries-of-the-hand-zone%C3%A2-2-exercise-with-an-exoskeleton-compared-to-physical-therapy
#12
Joachim Gülke, Martin Mentzel, Gert Krischak, David Gulkin, Daniel Dornacher, Nikolaus Wachter
BACKGROUND: These days there are different types of aftercare following flexor tendon injury. Patients in this study received a dynamic Kleinert protocol and additionally two different postoperative treatments. Both treatment groups were compared to each other and results were put into perspective when compared to other treatment options. METHODS: Sixty-two patients presenting with clean lesions of the two flexor tendons in zone 2 received postoperative treatment with a dynamic Kleinert protocol...
July 20, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28729373/the-importance-of-managing-the-patient-and-not-the-gene-expanded-phenotype-of-gle1-associated-arthrogryposis
#13
Queenie K-G Tan, Allyn McConkie-Rosell, Jane Juusola, Kathryn E Gustafson, Carolyn E Pizoli, Anne F Buckley, Yong-Hui Jiang
GLE1 encodes a protein important for mRNA export and appears to play roles in translation initiation and termination as well. Pathogenic variants in GLE1 mutations have been associated with lethal contracture syndrome (LCCS1) and Lethal Arthrogryposis with Anterior Horn Cell Disease (LAAHD); phenotypes reported in individuals include fetal akinesia and a severe form of motor neuron disease, typically presenting with prenatal symptoms and perinatal lethality. In this paper, we identified bi-allelic missense mutations in GLE1 by trio whole exome sequencing (WES) in an individual affected with congenital motor weakness and contractures as well as feeding and respiratory difficulties...
July 20, 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28728331/surgery-requiring-detailed-preoperative-simulation-and-scar-de-epithelialization-to-repair-severe-postoperative-scarring-from-gastroschisis
#14
Naohiro Ishii, Tomito Oji, Kazuo Kishi
We present the case of a patient with severe postoperative scarring from surgical treatment for gastroschisis, with the intestine located immediately under the dermal scar. Although many patients are unsatisfied with the results of scar repair treatment, few reports exist regarding severe or difficult cases involving the surgical repair of postoperative scar contracture. We achieved an excellent result via simulation involving graph paper drawings that were generated using computed tomography images as a reference, followed by dermal scar deepithelialization...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28727367/prospective-evaluation-of-vesicourethral-anastomosis-outcomes-in-robotic-radical-prostatectomy-during-early-experience-in-a-university-hospital
#15
Lucas Medeiros Burttet, Gabrielle Aguiar Varaschin, Andre Kives Berger, Leandro Totti Cavazzola, Milton Berger, Brasil Silva
PURPOSE: Robotic assisted radical prostatectomy (RARP) presents challenges for the surgeon, especially during the initial learning curve. We aimed to evaluate early and mid-term functional outcomes and complications related to vesicourethral anastomosis (VUA), in patients who underwent RARP, during the initial experience in an academic hospital. We also assessed possible predictors of postoperative incontinence and compared these results with the literature. MATERIALS AND METHODS: We prospectively collected data from consecutive patients that underwent RARP...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28726812/a-patient-with-germ-line-gain-of-function-pdgfrb-p-n666h-mutation-and-marked-clinical-response-to-imatinib
#16
Dinel Pond, Florence A Arts, Nancy J Mendelsohn, Jean-Baptiste Demoulin, Gunter Scharer, Yoav Messinger
PurposeHeterozygous germ-line activating mutations in PDGFRB cause Kosaki and Penttinen syndromes and myofibromatosis. We describe a 10-year-old child with a germ-line PDGFRB p.N666H mutation who responded to the tyrosine kinase inhibitor imatinib by inhibition of PDGFRB.MethodsThe impact of p.N666H on PDGFRB function and sensitivity to imatinib was studied in cell culture.ResultsCells expressing the p.N666H mutation showed constitutive PDGFRB tyrosine phosphorylation. PDGF-independent proliferation was abolished by imatinib at 1 μM concentration...
July 20, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28726266/survival-among-children-with-lethal-congenital-contracture-syndrome-11-caused-by-novel-mutations-in-the-gliomedin-gene-gldn
#17
Jennifer A Wambach, Georg M Stettner, Tobias B Haack, Karin Writzl, Andreja Škofljanec, Aleš Maver, Francina Munell, Stephan Ossowski, Mattia Bosio, Daniel J Wegner, Marwan Shinawi, Dustin Baldridge, Bader Alhaddad, Tim M Strom, Dorothy K Grange, Ekkehard Wilichowski, Robin Troxell, James Collins, Barbara B Warner, Robert E Schmidt, Alan Pestronk, F Sessions Cole, Robert Steinfeld
Biallelic GLDN mutations have recently been identified among infants with lethal congenital contracture syndrome 11 (LCCS11). GLDN encodes gliomedin, a protein required for the formation of the nodes of Ranvier and development of the human peripheral nervous system. We report 6 infants and children from 4 unrelated families with biallelic GLDN mutations, 4 of whom survived beyond the neonatal period into infancy, childhood, and late adolescence with intensive care and chronic respiratory and nutritional support...
July 20, 2017: Human Mutation
https://www.readbyqxmd.com/read/28725593/buccal-mucosal-graft-urethroplasty-in-men-risk-factors-for-recurrence-and-complications-a-third-referral-centre-experience-in-anterior-urethroplasty-using-buccal-mucosal-graft
#18
Marco Spilotros, Neha Sihra, Sachin Malde, Mahreen H Pakzad, Rizwan Hamid, Jeremy L Ockrim, Tamsin J Greenwell
BACKGROUND: Urethral stricture disease is a challenging condition to treat and several approaches including direct visual internal urethrotomy (DVIU) and anastomotic or augmentation urethroplasties based on the use of flaps and graft have been reported. The aim of this study is to determine risk factors for stricture recurrence and complications in patients having buccal mucosal graft (BMG) urethroplasty for anterior urethral stricture under a single surgeon in a third referral centre in UK...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28724781/muscle-disuse-caused-by-botulinum-toxin-injection-leads-to-increased-central-gain-of-the-stretch-reflex-in-the-rat
#19
Jessica Pingel, Hans Hultborn, Lui Naslund-Koch, Dennis Bo Jensen, Jacob Wienecke, Jens Bo Nielsen
Botulinum toxin (Btx) is used in children with cerebral palsy and other neurological patients to diminish spasticity and reduce the risk of development of contractures. Here, we investigated changes in the central gain of the stretch reflex circuitry in response to botulinum toxin injection in the triceps surae muscle in rats. Experiments were performed in 21 rats. 8 rats were in a control group and 13 rats were injected with 6 IU of Btx in the left triceps surae muscle. Two weeks after Btx injection larger monosynaptic reflexes (MSR) were recorded from the left (injected) than the right (non-injected) L4 + L5 ventral roots following stimulation of the corresponding dorsal roots...
July 19, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28721627/two-chinese-pedigrees-of-blau-syndrome-with-thirteen-affected-members
#20
REVIEW
Di Wu, Min Shen
Blau syndrome (BS) is a rare autosomal dominant autoinflammatory disease characterized by the clinical triad of dermatitis, arthritis, and uveitis. It is caused by mutations in nucleotide-binding oligomerization domain-containing protein-2 (NOD2) gene. BS has been widely reported in Caucasians but cases documented in China are scarce. We reported two Chinese families with BS, which were by far the two largest pedigrees in the Chinese population. We identified two unrelated families with BS. The phenotypes and genotypes of these patients were reviewed and compared with previous cohorts...
July 18, 2017: Clinical Rheumatology
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