keyword
https://read.qxmd.com/read/38532864/randomized-clinical-trial-of-aspirin-as-prophylaxis-for-thromboembolism-in-hip-arthroplasty
#1
JOURNAL ARTICLE
Raul Carneiro Lins, Epitacio Rolim, Yago Andrade Lima, Rodrigo Rodrigues de Sousa Moura
OBJECTIVE: This study aims to evaluate aspirin as a chemical prophylaxis (200 mg) in total hip arthroplasty. METHODS: the study compared two groups and used ultrasonography (USG) to screen for low-deep venous thrombosis. Group 1 received 600 mg (control), and Group 2 received 200 mg of (intervention), associated with the use of elastic compression stockings and early walking. RESULTS: fourteen patients were allocated to Group A (200mg), and 16 to Group B (600mg); in group A (200mg), 3 cases with thrombus below the popliteal vein were detected at the first USG examination...
2024: Acta Ortopedica Brasileira
https://read.qxmd.com/read/38531623/risk-stratification-based-thromboprophylaxis-does-not-affect-mortality-after-fast-track-hip-and-knee-arthroplasty
#2
JOURNAL ARTICLE
Annette M Moisander, Konsta Pamilo, Jukka Huopio, Hannu Kautiainen, Anne Kuitunen, Juha Paloneva
BACKGROUND AND PURPOSE: Use of thromboprophylaxis effectively prevents pulmonary embolism (PE) and deaths after total hip and knee arthroplasty (THA and TKA). The optimum length of thromboprophylaxis is not known and has traditionally been based on the type of operation. Nowadays, a more individualized approach is preferred. This study analyzed if risk stratification-based planning of thromboprophylaxis has an association with the all-cause mortality after fast-track THA and TKA. PATIENTS AND METHODS: We compared fast-track THAs and TKAs operated between 2015-2016 and 2020-2021...
March 26, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38529999/risk-factors-for-venous-thromboembolism-after-primary-total-joint-arthroplasty-an-analysis-of-7511-taiwanese-patients
#3
JOURNAL ARTICLE
Wei-Lin Chang, Fu-Yuan Pai, Shang-Wen Tsai, Cheng-Fong Chen, Po-Kuei Wu, Wei-Ming Chen
BACKGROUND: The need for thromboprophylaxis in Asian patients after primary total joint arthroplasty (TJA) remains inconclusive. We aimed to identify the risk factors for venous thromboembolism (VTE) events following primary TJA in a Taiwanese population. METHODS: From January 2010 through December 2019, we studied 7,511 patients receiving primary TJA from a single surgeon. We validated the incidence and risk factors for 30-day and 90-day symptomatic VTE events, including age, sex, body mass index (BMI), smoking, medical comorbidities, VTE history, presence of varicose veins, total knee arthroplasty (TKA) versus total hip arthroplasty (THA), unilateral versus bilateral procedure and receipt of VTE prophylaxis, transfusion, and length of stay...
March 26, 2024: Journal of the Chinese Medical Association: JCMA
https://read.qxmd.com/read/38521460/tranexamic-acid-reduces-perioperative-blood-loss-and-postoperative-hemoglobin-loss-during-total-ankle-arthroplasty-a-systematic-review-and-meta-analysis-of-clinical-comparative-studies
#4
REVIEW
James J Butler, Ragul Rajivan, Kishore Konar, Utkarsh Anil, Mohammad T Azam, Raymond Walls, John G Kennedy
IMPORTANCE: Peri-operative blood loss during joint replacement procedures is a modifiable risk factor that impacts wound complications, hospital stay and total costs. Tranexamic acid (TXA) is an anti-fibrinolytic that has been widely used in orthopedic surgery, but its efficacy in the setting of total ankle arthroplasty (TAA) has not been quantified to date. AIM: The purpose of this systematic review and meta-analysis was to evaluate the efficacy and safety of administering TXA in patients undergoing TAA...
March 21, 2024: Journal of ISAKOS
https://read.qxmd.com/read/38479723/total-shoulder-arthroplasty-in-patients-with-factor-v-leiden
#5
JOURNAL ARTICLE
Katie M Zehner, Joshua G Sanchez, Meera M Dhodapkar, Maxwell Modrak, Xuan Luo, Jonathan N Grauer
BACKGROUND: Anatomic and reverse total shoulder arthroplasty (TSA) are effective treatment options for end-stage glenohumeral osteoarthritis. However, consideration for pre-existing conditions must be taken into account. Factor V Leiden (FVL), the most common inherited thrombophilia, is one such condition that predisposes to a prothrombotic state and may affect perioperative and longer-term outcomes following TSA. METHODS: Adult patients undergoing primary TSA for osteoarthritis indication were identified in the 2010 through October 2021 PearlDiver M157 database...
March 11, 2024: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/38467650/compliance-with-australian-orthopaedic-association-guidelines-does-not-reduce-the-risk-of-venous-thromboembolism-after-total-hip-and-knee-arthroplasty
#6
JOURNAL ARTICLE
Helen Badge, Tim Churches, Justine M Naylor, Wei Xuan, Elizabeth Armstrong, Leeanne Gray, John Fletcher, Iain Gosbell, Chung-Wei Christine Lin, Ian A Harris
Preventing avoidable venous-thrombo-embolism (VTE) is a priority to improve patient and service outcomes after total hip and total knee arthroplasty (THA, TKA), but compliance with relevant clinical guidelines varies. This study aims to determine the degree to which prophylaxis was compliant with Australian Orthopaedic Association (AOA) VTE prophylaxis guidelines and whether non-compliance is associated with increased risk of VTE. A prospective multi-centre cohort study of adults with osteoarthritis undergoing primary TKA/THA was completed at 19 high-volume public and private hospitals...
March 12, 2024: Scientific Reports
https://read.qxmd.com/read/38462141/outcomes-following-total-hip-arthroplasty-in-patients-who-have-von-willebrand-disease-depend-on-postoperative-anticoagulation
#7
JOURNAL ARTICLE
Will Jiang, Joshua Sanchez, Meera M Dhodapkar, Zachary J Radford, Lee E Rubin, Jonathan N Grauer
BACKGROUND: Von Willebrand disease (VWD) is the most common congenital bleeding disorder. This autosomal dominant condition arises from quantitative or qualitative defects of Von Willebrand factor. To our knowledge, this study leveraged a national database to characterize the largest VWD cohort of total hip arthroplasty (THA) patients to date, assessing 90-day postoperative adverse events and 5-year revision-free survival. METHODS: Adult patients who underwent primary THA for osteoarthritis were identified from January 2010 to October 2021 in a nationwide database...
March 8, 2024: Journal of Arthroplasty
https://read.qxmd.com/read/38461402/optimised-fast-track-protocols-in-total-knee-arthroplasty-determine-shorter-hospitalisation-time-and-lower-perioperative-postoperative-complications
#8
JOURNAL ARTICLE
Riccardo Compagnoni, Francesco Puglia, Mauro Magnani, Raymond Klumpp, Paolo Ferrua, Filippo Calanna, Carlo Francesco Minoli, Daniele Genco, Alessandra Menon, Pietro Simone Randelli
PURPOSE: This literature review aims to present evidence-based clinical recommendations for the eight most debated topics related to perioperative management in total knee arthroplasty: counselling, prehabilitation, transfusion risk, tranexamic acid, drainage, analgesia, urinary catheter and compression stockings. METHODS: A multidisciplinary team conducted a systematic review on these topics. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for the literature review and result presentation...
March 10, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
https://read.qxmd.com/read/38454388/epidemiology-and-prognostic-factors-for-new-onset-deep-venous-thrombosis-after-unicompartmental-knee-arthroplasty-a-retrospective-study
#9
JOURNAL ARTICLE
Jia Li, Haijing Zhang, Xiaoguang Yu, Guoxing Jia, Sen Liu, Guobin Liu
BACKGROUND: Patients who underwent knee joint arthroplasty were at risk of venous thromboembolic events (VTEs), however, less studies were conducted to demonstrate the epidemiology and risk factors of deep venous thrombosis (DVT) following unicompartmental knee arthroplasty (UKA). Objective of this study was to explore the incidence and prognostic factors of DVT after UKA. METHODS: Patients who underwent primary UKA from December 2018 to June 2022 were recruited in this study...
March 7, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38443248/the-safety-and-efficacy-of-noacs-versus-lmwh-for-thromboprophylaxis-after-tha-or-tka-a-systemic-review-and-meta-analysis
#10
REVIEW
Kai Ding, Wei Yan, Yifan Zhang, Jiaxing Li, Congxin Li, Chunhui Liang
The differences in the safety and efficacy of anticoagulation between different types of new oral anticoagulants(NOACs) and low molecular weight heparin(LMWH) are still controversial. The main purposes of this study were to analyze safety and efficacy of NOACs versus LMWH for thromboprophylaxis, and perform subgroup analyses stratified by individual NOACs and different populations after total hip arthroplasty (THA) or total knee arthroplasty (TKA). Literature search was performed in PubMed, EMBASE, Cochrane Library, CNKI and Wanfang databases until June 31, 2022...
March 4, 2024: Asian Journal of Surgery
https://read.qxmd.com/read/38430972/aahks-clinical-research-award-extended-postoperative-oral-tranexamic-acid-in-total-knee-arthroplasty-a-randomized-controlled-pilot-study
#11
JOURNAL ARTICLE
Mateo J Kirwan, Zachary R Diltz, Derek T Dixon, Carlos A Rivera-Peraza, Christal J Gammage, Willliam M Mihalko, James W Harkess, James L Guyton, John R Crockarell, Marcus C Ford
INTRODUCTION: Perioperative tranexamic acid (TXA) use with total knee arthroplasty (TKA) is widely accepted today. Recently, a few international groups have published on the safety and outcomes of extending TXA use in the postoperative period. Through a double-blinded, randomized control trial, we aimed to investigate the safety and clinical efficacy of extended postoperative oral TXA use in TKA performed in an American, free-standing ambulatory surgery center (ASC). METHODS: Based on a power analysis, 40 patients undergoing primary TKA were randomized into two groups: extended oral TXA versus placebo...
February 29, 2024: Journal of Arthroplasty
https://read.qxmd.com/read/38412226/standard-review-testosterone-replacement-therapy-in-orthopaedic-surgery
#12
JOURNAL ARTICLE
Randy M Cohn, Maximillian P Ganz, Giles R Scuderi
Testosterone replacement therapy (TRT) is an indicated treatment of several medical conditions including late-onset hypogonadism, congenital syndromes, and gender affirmation hormonal therapy. Increasing population age, medical benefits, and public awareness of TRT have resulted in increased prevalence of its utilization. However, TRT is not without concern for adverse risks including venous thromboembolic complications, cardiovascular events, and prostate issues. In the field of orthopaedic surgery, research is beginning to delineate the complex relationship between TRT and the development of orthopaedic conditions and potential effects on surgical interventions and outcomes...
February 27, 2024: Journal of the American Academy of Orthopaedic Surgeons
https://read.qxmd.com/read/38346881/impact-of-intraosseous-regional-administration-of-tranexamic-acid-in-total-knee-arthroplasty-on-perioperative-blood-loss-a-protocol-for-a-randomised-controlled-trial
#13
JOURNAL ARTICLE
Zhanqi Wei, Muyang Yu, Yiming Xu, Xisheng Weng, Bin Feng
INTRODUCTION: Total knee arthroplasty (TKA) is a common surgical intervention to treat joint diseases. However, TKA is associated with significant blood loss. Tranexamic acid (TXA) has been used to reduce perioperative bleeding and postoperative blood transfusion. This study aims to explore the effectiveness and safety of intraosseous regional administration (IORA) of TXA in TKA and compare differences in perioperative blood loss between IORA of TXA, intravenous infusion of TXA, and combined IORA and intravenous infusion of TXA...
February 12, 2024: BMJ Open
https://read.qxmd.com/read/38342627/effect-of-knee-valgus-deformity-on-symptomatic-venous-thromboembolism-and-prosthesis-revision-risk-after-total-knee-arthroplasty-a-multicenter-retrospective-study
#14
JOURNAL ARTICLE
Kuishuai Xu, Liang Zhang, Tengbo Yu, Xia Zhao, Yingze Zhang
OBJECTIVE: Symptomatic venous thromboembolism (VTE) and prosthesis failure are the most serious complications after total knee arthroplasty (TKA). However, whether knee valgus deformity aggravates these complications has not been fully clarified. To study the difference between perioperative symptomatic VTE and prosthesis revision rate in patients with valgus knee osteoarthritis by comparing with patients undergoing TKA for varus deformity and analyze the reasons for revision. At the same time, the distribution and radiographic features of lower extremity deep venous thrombosis were recorded...
February 11, 2024: Orthopaedic Surgery
https://read.qxmd.com/read/38325570/-translated-article-risk-of-venous-thromboembolism-in-thromboprophylaxis-between-aspirin-and-low-molecular-weight-heparins-after-total-hip-arthroplasty-or-total-knee-arthroplasty-systematic-review-and-meta-analysis
#15
REVIEW
J H Núñez, F Moreira, B Escudero-Cisneros, J Martínez-Peña, D Bosch-García, F Angles, E Guerra-Farfán
INTRODUCTION: The aim of this study was to evaluate the efficacy of aspirin versus low molecular weight heparins (LMWH) for the prophylaxis of venous thromboembolism (VTE), deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing total knee arthroplasty (TKA) and/or total hip arthroplasty (THA). MATERIALS AND METHODS: Systematic review and meta-analysis. Sixteen studies were selected. The risk of VTE, DVT and PE were analysed. Mortality, risk of bleeding and surgical wound complications was also analysed...
February 5, 2024: Revista Española de Cirugía Ortopédica y Traumatología
https://read.qxmd.com/read/38325530/trends-in-deep-vein-thrombosis-prophylaxis-after-total-knee-arthroplasty-2016-to-2021
#16
JOURNAL ARTICLE
Jeremy A Dubin, Sandeep S Bains, Daniel Hameed, Ethan A Remily, Mallory C Moore, Michael A Mont, James Nace, Ronald E Delanois
INTRODUCTION: In 2011, the American Academy of Orthopaedic Surgeons released a consensus recommending venous thromboembolism (VTE) prophylaxis after total knee arthroplasty (TKA). The purpose of our study was to examine: (1) incidences of postoperative complications, including pulmonary embolism (PE), deep vein thrombosis (DVT), and transfusion rates; (2) trends from 2016 to 2021 in VTE prophylaxis; as well as (3) independent risk factors for 90-days total complications following TKA between aspirin, enoxaparin, rivaroxaban, and warfarin...
February 5, 2024: Journal of Arthroplasty
https://read.qxmd.com/read/38320106/trends-and-benefits-of-early-hip-arthroplasty-for-femoral-neck-fracture-in-china-a-national-cohort-study
#17
JOURNAL ARTICLE
Yuqing Wang, Qiao Jiang, Huizhong Long, Hu Chen, Jie Wei, Xiaoxiao Li, Haibo Wang, Dongxing Xie, Chao Zeng, Guanghua Lei
BACKGROUND: Limited studies have examined the benefits of early arthroplasty within 48 hours from admission to surgery for femoral neck fractures (FNFs). Using the national inpatient database, we aimed to investigate the trends in early arthroplasty within 48 hours for FNFs in China and to assess its effect on in-hospital complications and 30-day readmission patterns. MATERIALS AND METHODS: This was a retrospective cohort study. Patients receiving primary total hip arthroplasty (THA) or hemiarthroplasty (HA) for FNFs in the Hospital Quality Monitoring System between 2013 and 2019 were included...
February 5, 2024: International Journal of Surgery
https://read.qxmd.com/read/38309621/systematic-review-of-clinical-trials-on-antithrombotic-therapy-with-factor-xi-inhibitors
#18
REVIEW
A Franco-Moreno, N Muñoz-Rivas, J Torres-Macho, A Bustamante-Fermosel, C L Ancos-Aracil, E Madroñal-Cerezo
INTRODUCTION AND OBJECTIVE: Data from phase 2 clinical trials suggest that factor XI inhibitors may exhibit a more favorable efficacy/safety profile compared to current antithrombotic therapies. The aim of this systematic review is to analyze the available evidence derived from these studies. METHODS: A literature search in the PubMed, Cochrane Library, Scopus, EMBASE databases, and clinical trial registration platforms Clinical Trials and Cochrane Central Register of Controlled was conducted...
February 1, 2024: Revista Clínica Espanõla
https://read.qxmd.com/read/38305253/milvexian-a-focus-on-a-new-oral-anticoagulant-that-targets-factor-xia-for-thromboembolism-prophylaxis
#19
JOURNAL ARTICLE
Joseph Birchansky, William H Frishman
Drugs that target factor XI and/or XIa have been evaluated as alternatives to existing anticoagulants, in light of studies that indicate that a decrease in Factor XI/XIa levels or activity may result in a lower risk of thrombosis without a significant increase in bleeding risk. Milvexian is an investigational small-molecule factor XIa inhibitor that has recently completed phase 2 clinical trials. Preclinical studies were suggestive of its potential to prevent arterial and venous thrombosis. It was well-tolerated in healthy participants, as well as in participants with mild or moderate hepatic impairment and moderate or severe renal impairment...
February 2, 2024: Cardiology in Review
https://read.qxmd.com/read/38299020/initiating-versus-delaying-treatment-dose-anticoagulation-in-suspected-venous-thromboembolism-vte-in-post-operative-hip-and-knee-arthroplasty-patients-outcomes-and-risks
#20
JOURNAL ARTICLE
Deepak Menon, Emma Moran, Ikechukwu Ejiofor, Bernard van Duren, Hemant Pandit
BACKGROUND: Hip and knee arthroplasty is a risk factor for venous thromboembolism (VTE). Initiation of treatment-dose anticoagulation in the post-operative period in suspected cases prior to confirmed diagnosis involves balancing increased bleeding risk to VTE-associated morbidity. METHODS: A single-centre retrospective cohort study was undertaken comparing outcomes of empirical treatment of suspected VTE in post-operative elective lower-limb arthroplasty patients as opposed to delaying treatment until diagnosis is confirmed...
January 2024: Journal of Clinical Orthopaedics and Trauma
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