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tumor volume delineation

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https://www.readbyqxmd.com/read/29430662/on-the-feasibility-of-automatically-selecting-similar-patients-in-highly-individualized-radiotherapy-dose-reconstruction-for-historic-data-of-pediatric-cancer-survivors
#1
Marco Virgolin, Irma W E M van Dij, Jan Wiersma, Cécile M Ronckers, Cees Witteveen, Arjan Bel, Tanja Alderliesten, Peter A N Bosman
PURPOSE: The aim of this study is to establish the first step towards a novel and highly individualized 3D dose distribution reconstruction method, based on CT scans and organ delineations of recently treated patients. Specifically, the feasibility of automatically selecting the CT scan of a recently treated childhood cancer patient who is similar to a given historically treated child who suffered from Wilms' tumor is assessed. METHODS: A cohort of 37 recently treated children between 2 and 6 years old is considered...
February 12, 2018: Medical Physics
https://www.readbyqxmd.com/read/29426692/pancreatic-gross-tumor-volume-contouring-on-computed-tomography-ct-compared-with-magnetic-resonance-imaging-mri-results-of-an-international-contouring-conference
#2
William A Hall, Hanne D Heerkens, Eric S Paulson, Gert J Meijer, Alexis N Kotte, Paul Knechtges, Parag J Parikh, Michael F Bassetti, Percy Lee, Katharine L Aitken, Manisha Palta, Sten Myrehaug, Eugene J Koay, Lorraine Portelance, Edgar Ben-Josef, Beth A Erickson
PURPOSE: Accurate identification of the gross tumor volume (GTV) in pancreatic adenocarcinoma is challenging. We sought to understand differences in GTV delineation using pancreatic computed tomography (CT) compared with magnetic resonance imaging (MRI). METHODS AND MATERIALS: Twelve attending radiation oncologists were convened for an international contouring symposium. All participants had a clinical and research interest in pancreatic adenocarcinoma. CT and MRI scans from 3 pancreatic cases were used for contouring...
November 29, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29408780/role-of-radiotherapy-in-residual-pineal-parenchymal-tumors
#3
Narendra Kumar, Gulladamane Yogesh Srinivasa, Renu Madan, Pravin Salunke
OBJECTIVES: Surgical excision of pineal parenchymal tumors(PPT), though desirable for good long term outcome, may not always be possible. Role of adjuvant radiotherapy (RT) in residual PPT's is not well delineated. The purpose of this single institutional retrospective study is to assess the role of radiotherapy in residual PPT's. PATIENTS AND METHODS: Between 2006-2016, fourteen patients with residual PPT's were treated with adjuvant radiotherapy (12 with 3D conformal RT)...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29404766/pre-treatment-magnetic-resonance-based-texture-features-as-potential-imaging-biomarkers-for-predicting-event-free-survival-in-anal-cancer-treated-by-chemoradiotherapy
#4
Arnaud Hocquelet, Thibaut Auriac, Cynthia Perier, Clarisse Dromain, Marie Meyer, Jean-Baptiste Pinaquy, Alban Denys, Hervé Trillaud, Baudouin Denis De Senneville, Véronique Vendrely
AIM: To assess regular MRI findings and tumour texture features on pre-CRT imaging as potential predictive factors of event-free survival (disease progression or death) after chemoradiotherapy (CRT) for anal squamous cell carcinoma (ASCC) without metastasis. MATERIALS AND METHODS: We retrospectively included 28 patients treated by CRT for pathologically proven ASCC with a pre-CRT MRI. Texture analysis was carried out with axial T2W images by delineating a 3D region of interest around the entire tumour volume...
February 5, 2018: European Radiology
https://www.readbyqxmd.com/read/29398127/carotid-dosimetry-and-the-risk-of-carotid-blowout-syndrome-after-reirradiation-with-head-and-neck-stereotactic-body-radiation-therapy
#5
Brian J Gebhardt, John A Vargo, Diane Ling, Brianna Jones, Mary Mohney, David A Clump, James P Ohr, Robert L Ferris, Dwight E Heron
PURPOSE: To correlate carotid dose and risk of carotid blowout syndrome (CBOS) after stereotactic body radiation therapy (SBRT), hypothesizing that carotid dose does not correlate with CBOS. METHODS AND MATERIALS: We retrospectively reviewed 186 patients with recurrent, previously irradiated head and neck cancer treated between January 2008 and March 2013. Patients treated early in our experience with incomplete dosimetry were excluded from analysis (n = 111). A total of 75 patients were identified, providing 150 carotid arteries for analysis...
December 5, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29393179/irradiation-of-intracranial-gliomas-in-children
#6
Rolf-Dieter Kortmann, Clemens Seidel, Klaus Müller, Franz Wolfgang Hirsch
Attainment of local control is a cornerstone in the management of brain tumors in children. Treatment of progressive low-grade and all high-grade gliomas traditionally includes resection followed by fractionated radiotherapy (FRT) or FRT alone in neoplasms not amenable to surgical removal. While in younger children chemotherapy is typically used as a first-line non-surgical management option, FRT in such patients remains the standard of salvage therapy. Recent improvements in techniques for radiation treatment planning and delivery allow conformal and selective coverage of the target volume with a prescribed dose, sparing adjacent normal tissues to assure maximal tumor control and minimal toxicity...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29390527/comparison-of-different-automated-lesion-delineation-methods-for-metabolic-tumor-volume-of-18f-fdg-pet-ct-in-patients-with-stage-i-lung-adenocarcinoma
#7
Xiao-Yi Wang, Yan-Feng Zhao, Ying Liu, Yi-Kun Yang, Zheng Zhu, Ning Wu
The aim of the study was to investigate the suitable segmentation method in small, low uptake and heterogeneous nodules of stage I lung adenocarcinoma.133 stage I lung adenocarcinoma patients with F-FDG PET/CT scans were enrolled in this retrospective study. All lesions were divided into different groups according to nodule density, nodule size, and the maximum standard uptake value (SUVmax) level. Four different PET segmentation methods were performed, including percentage threshold of SUVmax (T42% and T42% × RC), gradient-based threshold (adaptive iterative algorithm, AT-AIA), and background-related threshold (adaptive thresholding at 40% SUVmax, AT40%) approaches...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390317/comparison-of-rigid-and-deformable-registration-through-the-respiratory-phases-of-four-dimensional-computed-tomography-image-data-sets-for-radiotherapy-after-breast-conserving-surgery
#8
Aiping Zhang, Jianbin Li, Heng Qiu, Wei Wang, Yanluan Guo
BACKGROUND: The aim of this study was to compare the geometric differences in gross tumor volume (GTV) and surgical clips propagated by rigid image registration (RIR) and deformable image registration (DIR) using a four-dimensional computed tomography (4DCT) image data set for patients treated with boost irradiation or accelerated partial breast irradiation after breast-conserving surgery (BCS). METHODS: The 4DCT data sets of 44 patients who had undergone BCS were acquired...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29372876/the-impact-of-spine-disease-relative-to-cranial-disease-on-perception-of-health-and-care-experience-an-analysis-of-1484-patients-in-a-tertiary-center
#9
Panagiotis Kerezoudis, Mohammed Ali Alvi, Daniel S Ubl, Kristine T Hanson, William E Krauss, Fredric B Meyer, Robert J Spinner, Elizabeth B Habermann, Mohamad Bydon
OBJECTIVE Patient-reported outcomes have been increasingly mandated by regulators and payers to evaluate hospital and physician performance. The purpose of this study is to delineate the differences in patient-reported experience of hospital care for cranial and spinal operations. METHODS The authors selected all patients who underwent inpatient, elective cranial or spinal procedures and completed the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey at a single, high-volume, tertiary care institution between October 2012 and September 2015...
January 26, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29364211/pet-and-mri-guided-irradiation-of-a-glioblastoma-rat-model-using-a-micro-irradiator
#10
Julie Bolcaen, Benedicte Descamps, Tom Boterberg, Christian Vanhove, Ingeborg Goethals
For decades, small animal radiation research was mostly performed using fairly crude experimental setups applying simple single-beam techniques without the ability to target a specific or well-delineated tumor volume. The delivery of radiation was achieved using fixed radiation sources or linear accelerators producing megavoltage (MV) X-rays. These devices are unable to achieve sub-millimeter precision required for small animals. Furthermore, the high doses delivered to healthy surrounding tissue hamper response assessment...
December 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29362858/repeatability-of-quantitative-18f-flt-uptake-measurements-in-solid-tumors-an-individual-patient-data-multi-center-meta-analysis
#11
G M Kramer, Y Liu, A J de Langen, E P Jansma, I Trigonis, M-C Asselin, A Jackson, L Kenny, E O Aboagye, O S Hoekstra, R Boellaard
INTRODUCTION: 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) positron emission tomography (PET) provides a non-invasive method to assess cellular proliferation and response to antitumor therapy. Quantitative 18F-FLT uptake metrics are being used for evaluation of proliferative response in investigational setting, however multi-center repeatability needs to be established. The aim of this study was to determine the repeatability of 18F-FLT tumor uptake metrics by re-analyzing individual patient data from previously published reports using the same tumor segmentation method and repeatability metrics across cohorts...
January 23, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29353835/-improvement-of-ct-imaging-with-a-metal-artifact-reduction-technique-for-radiation-treatment-planning-fundamental-study-of-structure-delineation-and-dose-calculation
#12
Takuya Nishitani, Kiyotomo Matsugi, Tetsuya Kitano, Hiroyuki Yamamoto, Masakazu Kaneko, Shigeki Yamada
In radiotherapy planning, CT images are widely used to delineate the gross tumor volume (GTV) and the organs at risks (OARs), which allows for the calculation of the dose distribution to each structure. The delineated contours of the GTV and OARs may become inaccurate, and subsequently result in the inaccurate derivation of the dose distribution, if there are metal artifacts present in the CT image. The metal artifact reduction technique, single energy metal artifact reduction (SEMAR), installed on the CT system (Aquilion ONETM Vision Edition, Toshiba Medical Systems Corporation) could potentially reduce metal artifacts...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29330751/prospective-trial-evaluating-the-sensitivity-and-specificity-of-3-4-dihydroxy-6-18f-fluoro-l-phenylalanine-18f-dopa-pet-and-mri-in-patients-with-recurrent-gliomas
#13
Ryan S Youland, Deanna H Pafundi, Debra H Brinkmann, Val J Lowe, Jonathan M Morris, Bradley J Kemp, Christopher H Hunt, Caterina Giannini, Ian F Parney, Nadia N Laack
Treatment-related changes can be difficult to differentiate from progressive glioma using MRI with contrast (CE). The purpose of this study is to compare the sensitivity and specificity of 18F-DOPA-PET and MRI in patients with recurrent glioma. Thirteen patients with MRI findings suspicious for recurrent glioma were prospectively enrolled and underwent 18F-DOPA-PET and MRI for neurosurgical planning. Stereotactic biopsies were obtained from regions of concordant and discordant PET and MRI CE, all within regions of T2/FLAIR signal hyperintensity...
January 13, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29330658/patient-specific-model-based-segmentation-of-brain-tumors-in-3d-intraoperative-ultrasound-images
#14
Elisee Ilunga-Mbuyamba, Juan Gabriel Avina-Cervantes, Dirk Lindner, Felix Arlt, Jean Fulbert Ituna-Yudonago, Claire Chalopin
PURPOSE: Intraoperative ultrasound (iUS) imaging is commonly used to support brain tumor operation. The tumor segmentation in the iUS images is a difficult task and still under improvement because of the low signal-to-noise ratio. The success of automatic methods is also limited due to the high noise sensibility. Therefore, an alternative brain tumor segmentation method in 3D-iUS data using a tumor model obtained from magnetic resonance (MR) data for local MR-iUS registration is presented in this paper...
January 12, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29306379/variation-assessment-of-deformable-registration-in-stereotactic-radiosurgery
#15
C-S Chang, R Shih, J-M Hwang, K-S Chuang
INTRODUCTION: The regular functions of CT-MRI registration include delineation of targets and organs-at-risk (OARs) in radiosurgery planning. The question of whether deformable image registration (DIR) could be applied to stereotactic radiosurgery (SRS) in its place remains a subject of debate. METHODS: This study collected data regarding 16 patients who had undergone single-fraction SRS treatment. All lesions were located close to the brainstem. CT and MRI two image sets were registered by both rigid image registration (RIR) and DIR algorithms...
February 2018: Radiography
https://www.readbyqxmd.com/read/29238919/a-novel-fully-automatic-multilevel-thresholding-technique-based-on-optimized-intuitionistic-fuzzy-sets-and-tsallis-entropy-for-mr-brain-tumor-image-segmentation
#16
Taranjit Kaur, Barjinder Singh Saini, Savita Gupta
In the present paper, a hybrid multilevel thresholding technique that combines intuitionistic fuzzy sets and tsallis entropy has been proposed for the automatic delineation of the tumor from magnetic resonance images having vague boundaries and poor contrast. This novel technique takes into account both the image histogram and the uncertainty information for the computation of multiple thresholds. The benefit of the methodology is that it provides fast and improved segmentation for the complex tumorous images with imprecise gray levels...
December 13, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29222685/prediction-of-outcome-using-pretreatment-18f-fdg-pet-ct-and-mri-radiomics-in-locally-advanced-cervical-cancer-treated-with-chemoradiotherapy
#17
François Lucia, Dimitris Visvikis, Marie-Charlotte Desseroit, Omar Miranda, Jean-Pierre Malhaire, Philippe Robin, Olivier Pradier, Mathieu Hatt, Ulrike Schick
PURPOSE: The aim of this study is to determine if radiomics features from 18fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) images could contribute to prognoses in cervical cancer. METHODS: One hundred and two patients (69 for training and 33 for testing) with locally advanced cervical cancer (LACC) receiving chemoradiotherapy (CRT) from 08/2010 to 12/2016 were enrolled in this study. 18F-FDG PET/CT and MRI examination [T1, T2, T1C, diffusion-weighted imaging (DWI)] were performed for each patient before CRT...
December 9, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29221150/comparison-of-gross-tumor-volume-of-primary-oesophageal-cancer-based-on-contrast-enhanced-three-dimensional-four-dimensional-and-cone-beam-computed-tomography
#18
Chao-Yue Hu, Jian-Bin Li, Jin-Zhi Wang, Wei Wang, Feng-Xiang Li, Yan-Luan Guo
Background: To explore motion information included in 3DCT, 4DCT and CBCT by comparing volumetric and positional differences of GTV. Results: Independent of tumor location, significant differences were observed among volumes [IGTV10 > (IGTVCBCT or IGTVMIP) > (GTV3D or GTV4D50)]. The underestimations or overestimations between IGTV10 and IGTVCBCT were larger than those between IGTV10 and IGTVMIP (p < 0.001-0.011; p < 0.001-0.023). For upper oesophageal tumors, GTV4D50/IGTVCBCT negatively correlated with motion vector (r = -0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209915/classification-of-early-stage-non-small-cell-lung-cancers-on-computed-tomographic-images-into-histological-types-using-radiomic-features-interobserver-delineation-variability-analysis
#19
Akihiro Haga, Wataru Takahashi, Shuri Aoki, Kanabu Nawa, Hideomi Yamashita, Osamu Abe, Keiichi Nakagawa
Radiomics, which involves the extraction of large numbers of quantitative features from medical images, has attracted attention in cancer research. In radiomics analysis, tumor segmentation is a crucial step. In this study, we evaluated the potential application of radiomics for predicting the histology of early stage non-small cell lung cancer (NSCLC) by analyzing interobserver variability in tumor delineation. Forty patient datasets were included in this study, 21 involving adenocarcinomas and 19 involving squamous cell carcinomas...
December 5, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29205088/local-failure-after-radical-radiotherapy-of-non-small-cell-lung-cancer-in-relation-to-the-planning-fdg-pet-ct
#20
M Kandi, L Hoffmann, D Sloth Moeller, H H Schmidt, M M Knap, A A Khalil
OBJECTIVES: Local recurrence (rec) in lung cancer is associated with poor survival. This study examined whether the pattern of failure is associated with the most PET avid volume in the planning-FDG-PET/CT scan (p-PET/CT). METHODS: 162 consecutive inoperable NSCLC patients (pts) receiving radiotherapy between January 2012 and April 2014 were reviewed. Radiotherapy was delivered in 2 Gy/fraction (5f/week) to a total dose of 60-66 Gy. Pts were followed with CT scans every third month...
December 5, 2017: Acta Oncologica
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