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tumor volume delineation

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https://www.readbyqxmd.com/read/29222685/prediction-of-outcome-using-pretreatment-18f-fdg-pet-ct-and-mri-radiomics-in-locally-advanced-cervical-cancer-treated-with-chemoradiotherapy
#1
François Lucia, Dimitris Visvikis, Marie-Charlotte Desseroit, Omar Miranda, Jean-Pierre Malhaire, Philippe Robin, Olivier Pradier, Mathieu Hatt, Ulrike Schick
PURPOSE: The aim of this study is to determine if radiomics features from 18fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) images could contribute to prognoses in cervical cancer. METHODS: One hundred and two patients (69 for training and 33 for testing) with locally advanced cervical cancer (LACC) receiving chemoradiotherapy (CRT) from 08/2010 to 12/2016 were enrolled in this study. 18F-FDG PET/CT and MRI examination [T1, T2, T1C, diffusion-weighted imaging (DWI)] were performed for each patient before CRT...
December 9, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29221150/comparison-of-gross-tumor-volume-of-primary-oesophageal-cancer-based-on-contrast-enhanced-three-dimensional-four-dimensional-and-cone-beam-computed-tomography
#2
Chao-Yue Hu, Jian-Bin Li, Jin-Zhi Wang, Wei Wang, Feng-Xiang Li, Yan-Luan Guo
Background: To explore motion information included in 3DCT, 4DCT and CBCT by comparing volumetric and positional differences of GTV. Results: Independent of tumor location, significant differences were observed among volumes [IGTV10 > (IGTVCBCT or IGTVMIP) > (GTV3D or GTV4D50)]. The underestimations or overestimations between IGTV10 and IGTVCBCT were larger than those between IGTV10 and IGTVMIP (p < 0.001-0.011; p < 0.001-0.023). For upper oesophageal tumors, GTV4D50/IGTVCBCT negatively correlated with motion vector (r = -0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209915/classification-of-early-stage-non-small-cell-lung-cancers-on-computed-tomographic-images-into-histological-types-using-radiomic-features-interobserver-delineation-variability-analysis
#3
Akihiro Haga, Wataru Takahashi, Shuri Aoki, Kanabu Nawa, Hideomi Yamashita, Osamu Abe, Keiichi Nakagawa
Radiomics, which involves the extraction of large numbers of quantitative features from medical images, has attracted attention in cancer research. In radiomics analysis, tumor segmentation is a crucial step. In this study, we evaluated the potential application of radiomics for predicting the histology of early stage non-small cell lung cancer (NSCLC) by analyzing interobserver variability in tumor delineation. Forty patient datasets were included in this study, 21 involving adenocarcinomas and 19 involving squamous cell carcinomas...
December 5, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29205088/local-failure-after-radical-radiotherapy-of-non-small-cell-lung-cancer-in-relation-to-the-planning-fdg-pet-ct
#4
M Kandi, L Hoffmann, D Sloth Moeller, H H Schmidt, M M Knap, A A Khalil
OBJECTIVES: Local recurrence (rec) in lung cancer is associated with poor survival. This study examined whether the pattern of failure is associated with the most PET avid volume in the planning-FDG-PET/CT scan (p-PET/CT). METHODS: 162 consecutive inoperable NSCLC patients (pts) receiving radiotherapy between January 2012 and April 2014 were reviewed. Radiotherapy was delivered in 2 Gy/fraction (5f/week) to a total dose of 60-66 Gy. Pts were followed with CT scans every third month...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29204165/throwing-the-dart-blind-folded-comparison-of-computed-tomography-versus-magnetic-resonance-imaging-guided-brachytherapy-for-cervical-cancer-with-regard-to-dose-received-by-the-actual-targets-and-organs-at-risk
#5
Winnie Wing Ling Yip, Joyce Siu Yu Wong, Venus Wan Yan Lee, Frank Chi Sing Wong, Stewart Yuk Tung
Purpose: Computed tomography (CT) is inferior to magnetic resonance imaging (MRI) in cervical tumor delineation, but similar in identification of organs at risk (OAR). The trend to over-estimate high-risk and low-risk clinical target volume (HRCTV, IRCTV) on CT can lead to under-estimation of dose received by 90% (D90) of the 'actual' CTV. This study aims to evaluate whether CT-guided planning delivers adequate dose to the 'actual' targets while spares the OAR similarly. Material and methods: MRI-guided high-dose-rate image-guided brachytherapy (IGBT) was performed in 11 patients...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29187888/advantage-of-pet-ct-in-target-delineation-of-mri-negative-cervical-lymph-nodes-in-intensity-modulated-radiation-therapy-planning-for-nasopharyngeal-carcinoma
#6
Guanzhu Shen, Weiwei Xiao, Fei Han, Wei Fan, Xiao-Ping Lin, Lixia Lu, Lie Zheng, Ning Yue, Bruce Haffty, Chong Zhao, Xiaowu Deng
Introduction: In intensity-modulated radiation therapy (IMRT) planning for nasopharyngeal carcinoma (NPC), cervical lymph nodes (CLNs) that appear negative on magnetic resonance imaging (MRI) scans can be difficult to target. The purpose of this study was to assess the advantage of 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET/CT) for distinguishing MRI-negative CLNs and the effect of 18F-FDG PET/CT on diagnosis, target delineation, and dose prescription in IMRT planning for NPC...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29187426/18f-fdg-pet-guided-planning-and-re-planning-adaptive-radiotherapy-in-head-and-neck-cancer-current-state-of-art
#7
REVIEW
Eleonora Farina, Martina Ferioli, Paolo Castellucci, Arianna Farina, Giuseppe Zanirato Rambaldi, Savino Cilla, Silvia Cammelli, Stefano Fanti, Alessio G Morganti
BACKGROUND/AIM: A review of the literature is proposed as a contribution to current knowledge on technical, physical, and clinical issues about PET-guided planning and re-planning radiotherapy (RT) in head and neck cancer. MATERIALS AND METHODS: PubMed and Scopus electronic databases were searched for articles including clinical trials. Search terms were "gross tumor volume (GTV) delineation", "head and neck cancer", "radiotherapy", "adaptive radiotherapy" in combination with "PET"...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29175214/survival-in-patients-with-primary-dermatofibrosarcoma-protuberans-national-cancer-data-base-analysis
#8
Oleksandr Trofymenko, Jeremy S Bordeaux, Nathalie C Zeitouni
BACKGROUND: The predictors of mortality, second surgery, and postoperative radiation therapy for treating Dermatofibrosarcoma protuberans (DFSP) are not well described. OBJECTIVE: We sought to determine the impact of patient demographics, tumor characteristics, and treatment site and modality on survival after primary DFSP. METHODS: A retrospective analysis of data from the National Cancer Data Base program was performed for patients diagnosed with DFSP from 2003 to 2012...
November 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29173908/impact-of-pixel-based-machine-learning-techniques-on-automated-frameworks-for-delineation-of-gross-tumor-volume-regions-for-stereotactic-body-radiation-therapy
#9
Yasuo Kawata, Hidetaka Arimura, Koujirou Ikushima, Ze Jin, Kento Morita, Chiaki Tokunaga, Hidetake Yabu-Uchi, Yoshiyuki Shioyama, Tomonari Sasaki, Hiroshi Honda, Masayuki Sasaki
The aim of this study was to investigate the impact of pixel-based machine learning (ML) techniques, i.e., fuzzy-c-means clustering method (FCM), and the artificial neural network (ANN) and support vector machine (SVM), on an automated framework for delineation of gross tumor volume (GTV) regions of lung cancer for stereotactic body radiation therapy. The morphological and metabolic features for GTV regions, which were determined based on the knowledge of radiation oncologists, were fed on a pixel-by-pixel basis into the respective FCM, ANN, and SVM ML techniques...
October 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29173754/molecular-imaging-guided-radiotherapy-for-the-treatment-of-head-and-neck-squamous-cell-carcinoma-does-it-fulfill-the-promises
#10
REVIEW
Vincent Grégoire, Daniela Thorwarth, John Aldo Lee
With the routine use of intensity modulated radiation therapy for the treatment of head-and-neck squamous cell carcinoma allowing highly conformed dose distribution, there is an increasing need for refining both the selection and the delineation of gross tumor volumes (GTV). In this framework, molecular imaging with positron emission tomography and magnetic resonance imaging offers the opportunity to improve diagnostic accuracy and to integrate tumor biology mainly related to the assessment of tumor cell density, tumor hypoxia, and tumor proliferation into the treatment planning equation...
January 2018: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/29172270/18-fluorodeoxy-glucose-positron-emission-tomography-computed-tomography-18-fdg-pet-ct-for-gross-tumor-volume-gtv-delineation-in-gastric-cancer-radiotherapy
#11
Kinga Dębiec, Jerzy Wydmański, Izabela Gorczewska, Paulina Leszczyńska, Kamil Gorczewski, Wojciech Leszczyński, Andrea d’Amico, Michał Kalemba
Purpose: Evaluation of the 18-fluorodeoxy-glucose positron emission tomography-computed tomography (18-FDGPET/ CT) for gross tumor volume (GTV) delineation in gastric cancer patients undergoing radiotherapy. Methods: In this study, 29 gastric cancer patients (17 unresectable and 7 inoperable) were initially enrolled for radical chemoradiotherapy (45Gy/25 fractions + chemotherapy based on 5 fluorouracil) or radiotherapy alone (45Gy/25 fractions) with planning based on the 18-FDG-PET/CT images. Five patients were excluded due to excess blood glucose levels (1), false-negative positron emission tomography (1) and distant metastases revealed by 18-FDG-PET/CT (3)...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29157748/consensus-contouring-guidelines-for-postoperative-completely-resected-cavity-stereotactic-radiosurgery-for-brain-metastases
#12
Hany Soliman, Mark Ruschin, Lilyana Angelov, Paul D Brown, Veronica L S Chiang, John P Kirkpatrick, Simon S Lo, Anita Mahajan, Kevin S Oh, Jason P Sheehan, Scott G Soltys, Arjun Sahgal
PURPOSE: To propose contouring guidelines based on consensus contours generated by 10 international experts for cavity stereotactic radiosurgery (SRS), an emerging treatment option after surgical resection of brain metastases. No guidelines for contouring the surgical cavity volume have been previously reported. METHODS AND MATERIALS: Ten postoperative completely resected cases with varying clinical scenarios and locations within the brain were selected. For each case, 10 experts independently contoured the surgical cavity clinical target volume (CTV)...
October 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29141363/-characteristics-of-high-resolution-diffusion-weighted-imaging-apparent-diffusion-coefficient-histogram-and-its-correlations-with-cancer-stages-in-patients-with-nasopharyngeal-carcinoma
#13
G J Wang, Y Wang, Y Ye, F Chen, Y T Lu, S L Li
Objective: To investigate the features of apparent diffusion coefficient (ADC) histogram parameters based on entire tumor volume data in high resolution diffusion weighted imaging of nasopharyngeal carcinoma (NPC) and to evaluate its correlations with cancer stages. Methods: This retrospective study included 154 cases of NPC patients[102 males and 52 females, mean age (48±11) years]who had received readout segmentation of long variable echo trains of MRI scan before radiation therapy. The area of tumor was delineated on each section of axial ADC maps to generate ADC histogram by using Image J...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29128934/radiobiological-analysis-of-stereotactic-body-radiation-therapy-for-an-evidence-based-planning-target-volume-of-the-lung-using-multiphase-ct-images-obtained-with-a-pneumatic-abdominal-compression-apparatus-a-case-study
#14
Arun Chairmadurai, Harish Chandra Goel, Sandeep Kumar Jain, Pawan Kumar
This study evaluated the efficiency of stereotactic body radiation therapy of lung (SBRT-Lung) in generating a treatment volume using conventional multiple-phase three-dimensional computed tomography (3D-CT) of a patient immobilized with pneumatic abdominal compression. The institutional protocol for SBRT-Lung using the RapidArc technique relied on a planning target volume (PTV) delineated using 3D-CT and accounted for linear and angular displacement of the tumor during respiratory movements. The efficiency of the institutional protocol was compared with that of a conventional method for PTV delineation based on radiobiological estimates, such as tumor control probability (TCP) and normal tissue complication probability (NTCP), evaluated using dose-volume parameters...
November 11, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29113316/efficacy-of-sub-threshold-focused-ultrasound-irradiation-against-pancreatic-cancer-xenografts-evaluated-using-magnetic-resonance-imaging
#15
Rui Wang, Qian Guo, Yini Chen, Yihui Gao, Lei Wu, Bing Hu, Lixin Jiang
We investigated the efficacy and optimal period for using magnetic resonance imaging (MRI) to detect effects of sub-threshold focused ultrasound (FUS) irradiation. Nude mice bearing pancreatic cancer xenografts were subjected to MRI and pathology examnation before, and 24 h, 48 h, 2 weeks after irradiation, which were used to evaluate therapeutic effects of FUS. Tumor volumes were lower post-treatment than control group (P < 0.05). The T1WI turbo spin echo (T1WI-TSE) sequence was similar signal before and after treatment...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100548/an-investigation-into-the-range-dependence-of-target-delineation-strategies-for-stereotactic-lung-radiotherapy
#16
Dennis J Mohatt, John M Keim, Mathew C Greene, Ami Patel-Yadav, Jorge A Gomez, Harish K Malhotra
BACKGROUND: The "gold standard" approach for defining an internal target volume (ITV) is using 10 gross tumor volume (GTV) phases delineated over the course of one respiratory cycle. However, different sites have adopted several alternative techniques which compress all temporal information into one CT image set to optimize work flow efficiency. The purpose of this study is to evaluate alternative target segmentation strategies with respect to the 10 phase gold standard. METHODS: A Quasar respiratory motion phantom was employed to simulate lung tumor movement...
November 3, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29082656/visualization-of-4d-multimodal-imaging-data-and-its-applications-in-radiotherapy-planning
#17
Matthias Schlachter, Tobias Fechter, Sonja Adebahr, Tanja Schimek-Jasch, Ursula Nestle, Katja Bühler
PURPOSE: To explore the benefit of using 4D multimodal visualization and interaction techniques for defined radiotherapy planning tasks over a treatment planning system used in clinical routine (C-TPS) without dedicated 4D visualization. METHODS: We developed a 4D visualization system (4D-VS) with dedicated rendering and fusion of 4D multimodal imaging data based on a list of requirements developed in collaboration with radiation oncologists. We conducted a user evaluation in which the benefits of our approach were evaluated in comparison to C-TPS for three specific tasks: assessment of internal target volume (ITV) delineation, classification of tumor location in peripheral or central, and assessment of dose distribution...
October 29, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29058157/potential-of-asphericity-as-a-novel-diagnostic-parameter-in-the-evaluation-of-patients-with-68-ga-psma-hbed-cc-pet-positive-prostate-cancer-lesions
#18
Sebastian Meißner, Jan-Carlo Janssen, Vikas Prasad, Winfried Brenner, Gerd Diederichs, Bernd Hamm, Frank Hofheinz, Marcus R Makowski
BACKGROUND: The aim of this study was to evaluate the diagnostic value of the asphericity (ASP) as a novel quantitative parameter, reflecting the spatial heterogeneity of tracer uptake, in the staging process of patients with (68)Ga-PSMA-HBED-CC positron emission tomography (PET)-positive prostate cancer (PC). In this study, 37 patients (median age 72 years, range 52-82 years) with newly diagnosed PC, who received a (68)Ga-PSMA-HBED-CC PET fused with computed tomography ((68)Ga-PSMA-PET/CT), a magnetic resonance imaging (MRI) of the prostate, and a core needle biopsy (within 74...
October 23, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29057288/fully-automated-segmentation-of-prostate-whole-gland-and-transition-zone-in-diffusion-weighted-mri-using-convolutional-neural-networks
#19
Tyler Clark, Junjie Zhang, Sameer Baig, Alexander Wong, Masoom A Haider, Farzad Khalvati
Prostate cancer is a leading cause of cancer-related death among men. Multiparametric magnetic resonance imaging has become an essential part of the diagnostic evaluation of prostate cancer. The internationally accepted interpretation scheme (Pi-Rads v2) has different algorithms for scoring of the transition zone (TZ) and peripheral zone (PZ) of the prostate as tumors can appear different in these zones. Computer-aided detection tools have shown different performances in TZ and PZ and separating these zones for training and detection is essential...
October 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29056243/prognostic-significance-of-standardized-uptake-value-on-f18-fdg-pet-ct-in-patients-with-extranodal-nasal-type-nk-t-cell-lymphoma-a-multicenter-retrospective-analysis
#20
Kyoungjune Pak, Bum Soo Kim, Keunyoung Kim, In Joo Kim, Sungmin Jun, Young Jin Jeong, Hye Kyung Shim, Sung-Dong Kim, Kyu-Sup Cho
OBJECTIVES: The purpose of this study was to evaluate the value of parameters assessed with F18-flurodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in predicting relapse free survival and overall survival in patients with extranodal nasal type NK/T cell lymphoma. METHODS: Thirty-six patients with extranodal nasal type NK/T cell lymphoma, and who underwent PET/CT prior to curative treatment, were enrolled at five institutions. Volumes of interest covering the entire tumor volume were delineated on PET/CT images, and the maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured using thresholds of 40% of SUVmax...
October 12, 2017: American Journal of Otolaryngology
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