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tumor volume delineation

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https://www.readbyqxmd.com/read/29036692/clinical-utility-of-texture-analysis-of-18f-fdg-pet-ct-in-patients-with-stage-i-lung-cancer-treated-with-stereotactic-body-radiotherapy
#1
Kazuya Takeda, Kentaro Takanami, Yuko Shirata, Takaya Yamamoto, Noriyoshi Takahashi, Kengo Ito, Kei Takase, Keiichi Jingu
We evaluated the reproducibility and predictive value of texture parameters and existing parameters of 18F-FDG PET/CT images in Stage I non-small-cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT). Twenty-six patients with Stage I NSCLC (T1-2N0M0) were retrospectively analyzed. All of the patients underwent an 18F-FDG PET/CT scan before treatment and were treated with SBRT. Each tumor was delineated using PET Edge (MIM Software Inc., Cleveland, OH), and texture parameters were calculated using open-source code CGITA...
September 21, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29032421/computer-based-radiological-longitudinal-evaluation-of-meningiomas-following-stereotactic-radiosurgery
#2
Eli Ben Shimol, Leo Joskowicz, Ruth Eliahou, Yigal Shoshan
PURPOSE: Stereotactic radiosurgery (SRS) is a common treatment for intracranial meningiomas. SRS is planned on a pre-therapy gadolinium-enhanced T1-weighted MRI scan (Gd-T1w MRI) in which the meningioma contours have been delineated. Post-SRS therapy serial Gd-T1w MRI scans are then acquired for longitudinal treatment evaluation. Accurate tumor volume change quantification is required for treatment efficacy evaluation and for treatment continuation. METHOD: We present a new algorithm for the automatic segmentation and volumetric assessment of meningioma in post-therapy Gd-T1w MRI scans...
October 14, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29023527/dose-escalated-radiotherapy-for-unresectable-or-locally-recurrent-pancreatic-cancer-dose-volume-analysis-toxicity-and-outcome-of-28-consecutive-patients
#3
Sebastian Zschaeck, Bibiana Blümke, Peter Wust, David Kaul, Marcus Bahra, Hanno Riess, Fritz Klein, Marianne Sinn, Uwe Pelzer, Volker Budach, Pirus Ghadjar
PURPOSE: The role of radiotherapy for unresectable pancreatic cancer is controversial. A benefit of additional radiotherapy is supported by some observations. A dose-effect relationship was recently found by dose escalation employing image guided and intensity modulated radiotherapy. METHODS: We retrospectively evaluated 28 consecutive patients, all with history of extensive prior therapies for unresectable locally advanced/ recurrent pancreatic cancer (LAPC/LRPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28994459/neural-network-dose-models-for-knowledge-based-planning-in-pancreatic-sbrt
#4
Warren G Campbell, Moyed Miften, Lindsey Olsen, Priscilla Stumpf, Tracey Schefter, Karyn A Goodman, Bernard L Jones
PURPOSE: Stereotactic body radiation therapy (SBRT) for pancreatic cancer requires a skillful approach to deliver ablative doses to the tumor while limiting dose to the highly sensitive duodenum, stomach, and small bowel. Here, we develop knowledge-based artificial neural network dose models (ANN-DMs) to predict dose distributions that would be approved by experienced physicians. METHODS: Arc-based SBRT treatment plans for 43 pancreatic cancer patients were planned, delivering 30-33 Gy in five fractions...
October 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28993798/challenges-for-quality-assurance-of-target-volume-delineation-in-clinical-trials
#5
REVIEW
Amy Tien Yee Chang, Li Tee Tan, Simon Duke, Wai-Tong Ng
In recent years, new radiotherapy techniques have emerged that aim to improve treatment outcome and reduce toxicity. The standard method of evaluating such techniques is to conduct large scale multicenter clinical trials, often across continents. A major challenge for such trials is quality assurance to ensure consistency of treatment across all participating centers. Analyses from previous studies have shown that poor compliance and protocol violation have a significant adverse effect on treatment outcomes...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28986510/combined-18-f-fluciclovine-pet-mri-shows-potential-for-detection-and-characterization-of-high-risk-prostate-cancer
#6
Mattijs Elschot, Kirsten M Selnæs, Elise Sandsmark, Brage Krüger-Stokke, Øystein Størkersen, Guro F Giskeødegård, May-Britt Tessem, Siver A Moestue, Helena Bertilsson, Tone F Bathen
The objective of this study is to investigate if quantitative imaging features derived from combined (18)F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for detection and characterization of primary prostate cancer. Methods: Twenty-eight (28) patients diagnosed with high-risk prostate cancer underwent simultaneous (18)F-Fluciclovine PET/MRI before radical prostatectomy. Volumes-of-interest (VOIs) of prostate tumors, benign prostatic hyperplasia (BPH) nodules, prostatitis, and healthy tissue were delineated on T2-weighted images using histology as a reference...
October 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28980445/dosimetric-effects-of-anatomical-changes-during-fractionated-photon-radiation-therapy-in-pancreatic-cancer-patients
#7
Astrid van der Horst, Antonetta C Houweling, Geertjan van Tienhoven, Jorrit Visser, Arjan Bel
Pancreatic tumors show large interfractional position variation. In addition, changes in gastrointestinal gas volumes and body contour take place over the course of radiation therapy. We aimed to quantify the effect of these anatomical changes on target dose coverage, for the clinically used fiducial marker-based patient position verification and, for comparison, also for simulated bony anatomy-based position verification. Nine consecutive patients were included in this retrospective study. To enable fraction dose calculations on cone-beam CT (CBCT), the planning CT was deformably registered to each CBCT (13-15 per patient); gas volumes visible on CBCT were copied to the deformed CT...
October 4, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28979229/expertise-affects-inter-observer-agreement-at-peripheral-locations-within-a-brain-tumor
#8
Emily M Crowe, William Alderson, Jonathan Rossiter, Christopher Kent
Magnetic resonance imaging (MRI) is a crucial tool for clinical brain tumor detection and delineation. Since the process of gross tumor volume delineation resides with clinicians, a better understanding of how they perform this task is required if improvements in life expectancy are to be made. Novice-expert comparison studies have been used to examine the effect of expertise on abnormality detection, but little research has investigated expertise-related differences in brain tumor delineation. In this study, undergraduate students (novices) and radiologists (experts) inspected a combination of T1 and T2 single and whole brain MRI scans, each containing a tumor...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28951759/focal-therapy-for-prostate-cancer-the-technical-challenges
#9
REVIEW
Annette Haworth, Scott Williams
Focal therapy for prostate cancer has been proposed as an alternative treatment to whole gland therapy, offering the opportunity for tumor dose escalation and/or reduced toxicity. Brachytherapy, either low-dose-rate or high-dose-rate, provides an ideal approach, offering both precision in dose delivery and opportunity for a highly conformal, non-uniform dose distribution. Whilst multiple consensus documents have published clinical guidelines for patient selection, there are insufficient data to provide clear guidelines on target volume delineation, treatment planning margins, treatment planning approaches, and many other technical issues that should be considered before implementing a focal brachytherapy program...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28945871/tumor-volume-assessment-in-low-grade-gliomas-a-comparison-of-preoperative-magnetic-resonance-imaging-to-coregistered-intraoperative-3-dimensional-ultrasound-recordings
#10
Bodil Karoline Ravn Munkvold, Hans Kristian Bø, Asgeir Store Jakola, Ingerid Reinertsen, Erik Magnus Berntsen, Geirmund Unsgård, Sverre Helge Torp, Ole Solheim
BACKGROUND: Image guidance based on magnetic resonance imaging (MRI) and/or ultrasound (US) is widely used to aid decision making in glioma surgery, but tumor delineation based on these 2 modalities does not always correspond. OBJECTIVE: To analyze volumes of diffuse low-grade gliomas (LGGs) based on preoperative 3-D FLAIR MRIs compared to intraoperative 3-D US image recordings to quantitatively assess potential discrepancies between the 2 imaging modalities. METHODS: Twenty-three patients with supratentorial WHO grade II gliomas undergoing primary surgery guided by neuronavigation based on preoperative FLAIR MRI and navigated 3-D US were included...
August 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28919003/inter-observer-agreement-in-gtv-delineation-of-bone-metastases-on-ct-and-impact-of-mr-imaging-a-multicenter-study
#11
A S Gerlich, J M van der Velden, A N T J Kotte, C L Tseng, G Fanetti, W S C Eppinga, N Kasperts, M P W Intven, F A Pameijer, M E P Philippens, H M Verkooijen, E Seravalli
BACKGROUND AND PURPOSE: The use of Stereotactic Body Radiotherapy (SBRT) for bone metastases is increasing rapidly. Therefore, knowledge of the inter-observer differences in tumor volume delineation is essential to guarantee precise dose delivery. The aim of this study is to compare inter-observer agreement in bone metastases delineated on different imaging modalities. MATERIAL AND METHODS: Twenty consecutive patients with bone metastases treated with SBRT were selected...
September 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28901316/comparison-of-different-width-detector-on-the-gross-tumor-volume-delineation-of-the-solitary-pulmonary-lesion
#12
Dongping Shang, Jinbo Yue, Jianbin Li, Jinghao Duan, Yong Yin, Jinming Yu
PURPOSE: To explore the impact of different width detector on the volume and geometric position of gross tumor volume (GTV) of the solitary pulmonary lesion (SPL), as well as the impact on scanning time and radiation dose during the simulation. MATERIALS AND METHODS: Twenty-three patients with SPL underwent three-dimensional computed tomography (3DCT) simulation using different width detector, followed by four-dimensional computed tomography (4DCT) scans. GTV16 and GTV4 derived from different width detectors were compared with internal gross tumor volume (IGTV) generated from 4DCT on the volume and geometric position...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28885090/difference-in-target-definition-using-three-different-methods-to-include-respiratory-motion-in-radiotherapy-of-lung-cancer
#13
Ditte Sloth Møller, Marianne Marquard Knap, Tine Bisballe Nyeng, Azza Ahmed Khalil, Marianne Ingerslev Holt, Maria Kandi, Lone Hoffmann
INTRODUCTION: Minimizing the planning target volume (PTV) while ensuring sufficient target coverage during the entire respiratory cycle is essential for free-breathing radiotherapy of lung cancer. Different methods are used to incorporate the respiratory motion into the PTV. MATERIAL AND METHODS: Fifteen patients were analyzed. Respiration can be included in the target delineation process creating a respiratory GTV, denoted iGTV. Alternatively, the respiratory amplitude (A) can be measured based on the 4D-CT and A can be incorporated in the margin expansion...
September 8, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28879406/whole-tumor-histogram-analysis-of-the-cerebral-blood-volume-map-tumor-volume-defined-by-11c-methionine-positron-emission-tomography-image-improves-the-diagnostic-accuracy-of-cerebral-glioma-grading
#14
Rongli Wu, Yoshiyuki Watanabe, Atsuko Arisawa, Hiroto Takahashi, Hisashi Tanaka, Yasunori Fujimoto, Tadashi Watabe, Kayako Isohashi, Jun Hatazawa, Noriyuki Tomiyama
PURPOSE: This study aimed to compare the tumor volume definition using conventional magnetic resonance (MR) and 11C-methionine positron emission tomography (MET/PET) images in the differentiation of the pre-operative glioma grade by using whole-tumor histogram analysis of normalized cerebral blood volume (nCBV) maps. MATERIALS AND METHODS: Thirty-four patients with histopathologically proven primary brain low-grade gliomas (n = 15) and high-grade gliomas (n = 19) underwent pre-operative or pre-biopsy MET/PET, fluid-attenuated inversion recovery, dynamic susceptibility contrast perfusion-weighted magnetic resonance imaging, and contrast-enhanced T1-weighted at 3...
September 6, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28874205/target-volume-delineation-of-anal-cancer-based-on-magnetic-resonance-imaging-or-positron-emission-tomography
#15
Espen Rusten, Bernt Louni Rekstad, Christine Undseth, Ghazwan Al-Haidari, Bettina Hanekamp, Eivor Hernes, Taran Paulsen Hellebust, Eirik Malinen, Marianne Grønlie Guren
PURPOSE: To compare target volume delineation of anal cancer using positron emission tomography (PET) and magnetic resonance imaging (MRI) with respect to inter-observer and inter-modality variability. METHODS: Nineteen patients with anal cancer undergoing chemoradiotherapy were prospectively included. Planning computed tomography (CT) images were co-registered with 18F-fluorodexocyglucose (FDG) PET/CT images and T2 and diffusion weighted (DW) MR images. Three oncologists delineated the Gross Tumor Volume (GTV) according to national guidelines and the visible tumor tissue (GTVT)...
September 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28866897/superior-target-delineation-for-stereotactic-body-radiotherapy-of-bone-metastases-from-renal-cell-carcinoma-on-mri-compared-to-ct
#16
Fieke M Prins, Joanne M van der Velden, Anne S Gerlich, Alexis N T J Kotte, Wietse S C Eppinga, Nicolien Kasperts, Jorrit J Verlaan, Frank A Pameijer, Linda G W Kerkmeijer
BACKGROUND: In metastatic renal cell carcinoma (mRCC) there has been a treatment shift towards targeted therapy, which has resulted in improved overall survival. Therefore, there is a need for better local control of the tumor and its metastases. Image-guided stereotactic body radiotherapy (SBRT) in bone metastases provides improved symptom palliation and local control. With the use of SBRT there is a need for accurate target delineation. The hypothesis is that MRI allows for better visualization of the extend of bone metastases in mRCC and will optimize the accuracy of tumor delineation for stereotactic radiotherapy purposes, compared with CT only...
July 11, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28862549/outcomes-of-stereotactic-radiosurgery-for-foramen-magnum-meningiomas-an-international-multicenter-study
#17
Gautam U Mehta, Georgios Zenonos, Mohana Rao Patibandla, Chung Jung Lin, Amparo Wolf, Inga Grills, David Mathieu, Brendan McShane, John Y Lee, Kevin Blas, Douglas Kondziolka, Cheng-Chia Lee, L Dade Lunsford, Jason P Sheehan
OBJECTIVE Meningiomas are the most common benign extramedullary lesions of the foramen magnum; however, their optimal management remains undefined. Given their location, foramen magnum meningiomas (FMMs) can cause significant morbidity, and complete microsurgical removal can be challenging. Anterior and anterolateral FMMs carry greater risks with surgery, but they comprise the majority of these lesions. As an alternative to resection, stereotactic radiosurgery (SRS) has been used to treat FMMs in small case series...
September 1, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28862352/geometric-distortion-correction-in-prostate-diffusion-weighted-mri-and-its-effect-on-quantitative-apparent-diffusion-coefficient-analysis
#18
Gabriel Nketiah, Kirsten M Selnaes, Elise Sandsmark, Jose R Teruel, Brage Krüger-Stokke, Helena Bertilsson, Tone F Bathen, Mattijs Elschot
PURPOSE: To evaluate the effect of correction for B0 inhomogeneity-induced geometric distortion in echo-planar diffusion-weighted imaging on quantitative apparent diffusion coefficient (ADC) analysis in multiparametric prostate MRI. METHODS: Geometric distortion correction was performed in echo-planar diffusion-weighted images (b = 0, 50, 400, 800 s/mm(2) ) of 28 patients, using two B0 scans with opposing phase-encoding polarities. Histology-matched tumor and healthy tissue volumes of interest delineated on T2 -weighted images were mapped to the nondistortion-corrected and distortion-corrected data sets by resampling with and without spatial coregistration...
September 1, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28862115/new-language-and-old-problems-in-breast-cancer-radiotherapy
#19
Ion Christian Chiricuţă
New developments in breast cancer radiotherapy make possible new standards in treatment recommandations based on international guidelines. Developments in radiotherapy irradiation techniques from 2D to 3D-Conformal RT and to IMRT (Intensity Modulated Arc Therapy) make possible to reduce the usual side effects on the organs at risk as: skin, lung, miocard, bone, esophagus and brahial plexus. Dispite of all these progresses acute and late side effects are present. Side effects are as old as the radiotherapy was used...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28856515/automatic-detection-of-new-tumors-and-tumor-burden-evaluation-in-longitudinal-liver-ct-scan-studies
#20
R Vivanti, A Szeskin, N Lev-Cohain, J Sosna, L Joskowicz
PURPOSE: Radiological longitudinal follow-up of liver tumors in CT scans is the standard of care for disease progression assessment and for liver tumor therapy. Finding new tumors in the follow-up scan is essential to determine malignancy, to evaluate the total tumor burden, and to determine treatment efficacy. Since new tumors are typically small, they may be missed by examining radiologists. METHODS: We describe a new method for the automatic detection and segmentation of new tumors in longitudinal liver CT studies and for liver tumors burden quantification...
August 30, 2017: International Journal of Computer Assisted Radiology and Surgery
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