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tumor volume delineation

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https://www.readbyqxmd.com/read/29663419/accelerated-3d-bssfp-imaging-for-treatment-planning-on-an-mri-guided-radiotherapy-system
#1
Yu Gao, Ziwu Zhou, Fei Han, Minsong Cao, Narek Shaverdian, John V Hegde, Biraj B Bista, Michael Steinberg, Percy Lee, Ann Raldow, Daniel A Low, Yingli Yang, Peng Hu
PURPOSE: To introduce a compressed sensing and parallel imaging combined technique to reduce the acquisition time of planning MRI for MR-guided radiotherapy (MRgRT) systems. METHODS AND MATERIALS: A variable-density Poisson-Disk (VDPD) under-sampling acquisition along with compressed sensing reconstruction technique was developed and compared with the current planning MR protocol, which uses an optimized balanced-steady-state-free-precession sequence with 7.5-fold (7...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29652908/automatic-lesion-detection-and-segmentation-of-18f-fet-pet-in-gliomas-a-full-3d-u-net-convolutional-neural-network-study
#2
Paul Blanc-Durand, Axel Van Der Gucht, Niklaus Schaefer, Emmanuel Itti, John O Prior
INTRODUCTION: Amino-acids positron emission tomography (PET) is increasingly used in the diagnostic workup of patients with gliomas, including differential diagnosis, evaluation of tumor extension, treatment planning and follow-up. Recently, progresses of computer vision and machine learning have been translated for medical imaging. Aim was to demonstrate the feasibility of an automated 18F-fluoro-ethyl-tyrosine (18F-FET) PET lesion detection and segmentation relying on a full 3D U-Net Convolutional Neural Network (CNN)...
2018: PloS One
https://www.readbyqxmd.com/read/29623584/dosimetry-study-of-18-f-fmiso-pet-ct-hypoxia-imaging-guidance-on-intensity-modulated-radiation-therapy-for-non-small-cell-lung-cancer
#3
H Li, D Xu, X Han, Q Ruan, X Zhang, Y Mi, M Dong, S Guo, Y Lin, B Wang, G Li
OBJECTIVES: This study was to evaluate the feasibility of simultaneous integrated boost on tumor hypoxia area by studying the dosimetric change of hypoxia imaging guidance on intensity-modulated radiation therapy for non-small cell lung cancer (NSCLC). METHODS: Five NSCLC patients with large hypoxic volume participated in this study. FDG PET/CT images were fused with CT localization images to delineate gross tumor volume. FMISO PET/CT images were fused with CT localization images to delineate hypoxic biological target volume (BTV) (tissue maximum ratio ≥ 1...
April 5, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29613842/rapid-contour-based-segmentation-for-18-f-fdg-pet-imaging-of-lung-tumors-by-using-itk-snap-comparison-to-expert-based-segmentation
#4
Florent L Besson, Théophraste Henry, Céline Meyer, Virgile Chevance, Victoire Roblot, Elise Blanchet, Victor Arnould, Gilles Grimon, Malika Chekroun, Laurence Mabille, Florence Parent, Andrei Seferian, Sophie Bulifon, David Montani, Marc Humbert, Philippe Chaumet-Riffaud, Vincent Lebon, Emmanuel Durand
Purpose To assess the performance of the ITK-SNAP software for fluorodeoxyglucose (FDG) positron emission tomography (PET) segmentation of complex-shaped lung tumors compared with an optimized, expert-based manual reference standard. Materials and Methods Seventy-six FDG PET images of thoracic lesions were retrospectively segmented by using ITK-SNAP software. Each tumor was manually segmented by six raters to generate an optimized reference standard by using the simultaneous truth and performance level estimate algorithm...
April 3, 2018: Radiology
https://www.readbyqxmd.com/read/29609631/quantitative-analysis-of-respiration-induced-motion-of-each-liver-segment-with-helical-computed-tomography-and-4-dimensional-computed-tomography
#5
Yu-Lun Tsai, Ching-Jung Wu, Suzun Shaw, Pei-Chieh Yu, Hsin-Hua Nien, Louis Tak Lui
BACKGROUND: To analyze the respiratory-induced motion of each liver segment using helical computed tomography (helical CT) and 4-dimensional computed tomography (4DCT), and to establish the individual segment expansion margin of internal target volume (ITV) to facilitate target delineation of tumors in different liver segments. METHODS: Twenty patients who received radiotherapy with CT-simulation scanning of the whole liver in both helical CT and 10-phase-gated 4DCT were investigated, including 2 patients with esophagus cancer, 4 with lung cancer, 10 with breast cancer, 2 with liver cancer, 1 with thymoma, and 1 with gastric diffuse large B-cell lymphoma (DLBCL)...
April 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29598947/locoregional-extension-and-patterns-of-failure-for-nasopharyngeal-carcinoma-with-intracranial-extension
#6
Caineng Cao, Feng Jiang, Qifeng Jin, Ting Jin, Shuang Huang, Qiaoying Hu, Yuanyuan Chen, Yongfeng Piao, Yonghong Hua, Xinglai Feng, Xiaozhong Chen
OBJECTIVE: To evaluate the locoregional extension and patterns of failure for nasopharyngeal carcinoma (NPC) with intracranial extension to improve clinical target volume (CTV) delineation. PATIENTS AND METHODS: A total of 205 NPC patients with intracranial extension by magnetic resonance imaging (MRI) were retrospectively reviewed. RESULTS: According to the cumulative incidence rates of tumor invasion, we initially classified anatomic sites surrounding the nasopharynx into three risk grades: high risk (≥35%), medium risk (≥10-35%), and low risk (<10%)...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29598944/three-dimensional-imaging-assessment-of-anatomic-invasion-and-volumetric-considerations-for-chemo-radiotherapy-based-laryngeal-preservation-in-t3-larynx-cancer
#7
Mona Kamal, Sweet Ping Ng, Salman A Eraj, Crosby D Rock, Brian Pham, Jay A Messer, Adam S Garden, William H Morrison, Jack Phan, Steven J Frank, Adel K El-Naggar, Jason M Johnson, Lawrence E Ginsberg, Renata Ferrarotto, Jan S Lewin, Katherine A Hutcheson, Carlos E Cardenas, Mark E Zafereo, Stephen Y Lai, Amy C Hessel, Randal S Weber, G Brandon Gunn, Clifton D Fuller, Abdallah S R Mohamed, David I Rosenthal
OBJECTIVES: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and extent of involvement of primary tumor on treatment outcomes in a large uniform cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal preservation strategies. MATERIALS AND METHODS: The pretreatment contrast-enhanced computed tomography images of 90 patients with T3 laryngeal carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to calculate the 3D TV and define the extent of invasion...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29594207/patterns-of-loco-regional-failure-in-women-with-breast-cancer-treated-by-postmastectomy-conformal-electron-beam-radiation-therapy-pmert-large-scale-single-center-experience
#8
Gokoulakrichenane Loganadane, Zhen Xi, Hao Ping Xu, Noemie Grellier Adedjouma, Louis Bazire, Alain Fourquet, Youlia M Kirova
Purpose: To evaluate loco regional control and describe the patterns of loco regional failure in women with breast cancer irradiated by a previously described post-mastectomy highly conformal electron beam radiotherapy technique. Materials and methods: We included all women irradiated by PMERT for non-metastatic breast cancer (BC) between 2007 and 2011 in our department. All cases of bilateral BC were excluded. All patients who experienced loco regional recurrence have been studied...
June 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29580032/comparative-evaluation-of-a-6mv-flattened-beam-and-a-flattening-filter-free-beam-for-carcinoma-of-cervix-%C3%A2-imrt-planning-study
#9
Suresh Tamilarasu, Madeswaran Saminathan, S K Sharma, Anjali Pahuja, Abhinav Dewan
Purpose: Intensity modulated radiotherapy (IMRT) plan quality, beam on time and integral dose were compared using 6MV FB (Flattened Beam) and FFFB (Flattening filter free beam) for carcinoma of cervix. Materials and Methods: Ten patients with stage II–IIIB cervix cancer (Ca.Cx) were retrospectively identified from the department database. Target volume (TV) and organ at risk (OAR) were delineated as per Radiation Therapy Oncology Group (RTOG) cancer guidelines. Dose prescribed to planning target volume (PTV) was 50...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29578185/hypofractionated-postoperative-irradiation-in-localized-renal-cell-cancer-a-case-report-and-pertinent-literature-review
#10
Xiang-Rong Zhao, Guang-Lian Shan, Yong Zhang, Yong-Hua Yu
For localized the incidence of renal cell carcinoma (RCC), nephrectomy is the standard treatment. As RCC is generally regarded as a radiation-resistant tumor, the value of postoperative adjuvant radiotherapy is controversial. However, with new advance in radiotherapy (i.e., three-dimensional conformal radiation therapy [3DCRT] and intensity-modulated radiation therapy [IMRT]), target volume delineation, intensity modulation in treatment planning, and treatment delivery are more accurate with fewer adverse effect...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29573279/fdg-pet-metabolic-tumor-parameters-for-the-reirradiation-of-recurrent-head-and-neck-cancer
#11
Maria A Velez, Darlene Veruttipong, Pin-Chieh Wang, Elliot Abemayor, Maie St John, Mindi TenNapel, Allen M Chen
OBJECTIVE: The utility of fluorodeoxyglucose positron emission tomography (FDG-PET) imaging to predict outcome has been well-established for patients undergoing definitive radiation in the initial management of head and neck cancer. However, the usefulness of this modality in the recurrent setting remains uncertain. We sought to evaluate the prognostic value of metabolic tumor parameters measured on FDG-PET in patients treated by reirradiation for recurrent head and neck cancer. METHODS: Thirty-four tumors occurring in 29 patients were reirradiated and were evaluable...
March 24, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29559291/deep-learning-algorithm-for-auto-delineation-of-high-risk-oropharyngeal-clinical-target-volumes-with-built-in-dice-similarity-coefficient-parameter-optimization-function
#12
Carlos E Cardenas, Rachel E McCarroll, Laurence E Court, Baher A Elgohari, Hesham Elhalawani, Clifton D Fuller, Mona J Kamal, Mohamed A M Meheissen, Abdallah S R Mohamed, Arvind Rao, Bowman Williams, Andrew Wong, Jinzhong Yang, Michalis Aristophanous
PURPOSE: Automating and standardizing the contouring of clinical target volumes (CTVs) can reduce interphysician variability, which is one of the largest sources of uncertainty in head and neck radiation therapy. In addition to using uniform margin expansions to auto-delineate high-risk CTVs, very little work has been performed to provide patient- and disease-specific high-risk CTVs. The aim of the present study was to develop a deep neural network for the auto-delineation of high-risk CTVs...
February 7, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29556585/brachial-plexopathy-after-stereotactic-body-radiation-therapy-for-apical-lung-cancer-dosimetric-analysis-and-preliminary-clinical-outcomes
#13
Sumit S Sood, Christopher McClinton, Rajeev Badkul, Nathan Aguilera, Fen Wang, Allen M Chen
Purpose: The treatment of apical lung tumors with stereotactic body radiation therapy (SBRT) is challenging due to the proximity of the brachial plexus and the concern for nerve damage. Methods and materials: Between June 2009 and February 2017, a total of 75 consecutive patients underwent SBRT for T1-T3N0 non-small cell lung cancer involving the upper lobe of the lung. All patients were treated with 4-dimensional computed tomography (CT)-based image guided SBRT to a dose of 40 to 60 Gy in 3 to 5 fractions...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29554374/single-fractionated-stereotactic-radiosurgery-for-intracranial-meningioma-in-elderly-patients-25-year-experience-at-a-single-institution
#14
Hirotaka Hasegawa, Shunya Hanakita, Masahiro Shin, Tomoyuki Koga, Wataru Takahashi, Akihiro K Nomoto, Madoka Sakuramachi, Nobuhito Saito
BACKGROUND: Stereotactic radiosurgery (SRS) has been accepted as a therapeutic option for intracranial meningiomas; however, the detailed data on outcomes in elderly patients remain unclear. OBJECTIVE: To delineate the efficacy of SRS for meningiomas in elderly patients. METHODS: The outcomes of 67 patients aged ≥65 yr who underwent SRS for benign intracranial meningioma (World Health Organization grade I) between 1990 and 2014 at our institution were retrospectively analyzed...
April 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29552794/predictors-of-acute-hematologic-toxicity-attributable-to-palliative-radiotherapy-analysis-of-patient-characteristics-and-bone-marrow-dose-volume-parameters
#15
Tetsuo Saito, Ryo Toya, Tomohiko Matsuyama, Satoshi Ninomura, Natsuo Oya
PURPOSE: As predictors of hematologic toxicity (HT) after palliative radiotherapy (RT) have been studied insufficiently, we explored predictors of leukopenia, neutropenia, and thrombocytopenia attributable to palliative RT. METHODS: We retrospectively assessed patients with various solid tumors who had received palliative RT at our institution. Excluded from our study were patients who had undergone chemotherapy from one month before to one month after the start of RT...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29545124/radiation-therapy-for-the-whole-breast-executive-summary-of-an-american-society-for-radiation-oncology-astro-evidence-based-guideline
#16
Benjamin D Smith, Jennifer R Bellon, Rachel Blitzblau, Gary Freedman, Bruce Haffty, Carol Hahn, Francine Halberg, Karen Hoffman, Kathleen Horst, Jean Moran, Caroline Patton, Jane Perlmutter, Laura Warren, Timothy Whelan, Jean L Wright, Reshma Jagsi
INTRODUCTION: The purpose of this guideline is to offer recommendations on fractionation for whole breast irradiation (WBI) with or without a tumor bed boost and guidance on treatment planning and delivery. METHODS AND MATERIALS: The American Society for Radiation Oncology (ASTRO) convened a task force to address 5 key questions focused on dose-fractionation for WBI, indications and dose-fractionation for tumor bed boost, and treatment planning techniques for WBI and tumor bed boost...
March 8, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29521651/preradiotherapy-tumor-volume-in-local-control-of-squamous-cell-carcinoma-of-the-supraglottic-larynx
#17
Sommer Nurkic, Tarik Nurkic, Christopher G Morris, Robert J Amdur, William M Mendenhall
OBJECTIVES: Examine the utility of pretreatment computed tomography in predicting local control (LC) in squamous cell carcinoma of the supraglottic larynx treated with primary radiotherapy (RT). METHODS: In total, 167 patients treated between 1983 and 2013 were reviewed. Patients had received pretreatment diagnostic computed tomographic imaging of the larynx and neck from which primary tumor volume (PrTV) was delineated. LC, larynx function at last follow-up, and RT complications were recorded...
March 8, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29520733/dosimetric-analysis-of-unflattened-fffb-and-flattened-fb-photon-beam-energy-for-gastric-cancers-using-imrt-and-vmat-a-comparative-study
#18
Manindra Bhushan, Girigesh Yadav, Deepak Tripathi, Lalit Kumar, Vimal Kishore, Abhinav Dewan, Gourav Kumar, Inderjit Kaur Wahi, Munish Gairola
PURPOSE: To evaluate the feasibility of flattening filter free beam (FFFB) for the treatment of gastric tumors and to review their benefits over 6MV flatten beam (6MV_FFB). METHODS: Fifteen patients with histologically proven gastric carcinoma were selected. CT scans with slice thickness of 0.3 cm were acquired and planning target volume (PTV) and organ at risk (OAR) were delineated. Plans were made retrospectively for each patient for the prescription dose of 45 Gy/25 fractions to the PTV...
March 8, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29516344/a-surgical-strategy-using-a-fusion-image-constructed-from-11c-methionine-pet-18f-fdg-pet-and-mri-for-glioma-with-no-or-minimum-contrast-enhancement
#19
Makoto Ideguchi, Takafumi Nishizaki, Norio Ikeda, Tomomi Okamura, Yasue Tanaka, Natsumi Fujii, Machiko Ohno, Taichi Shimabukuro, Tokuhiro Kimura, Eiji Ikeda, Kazuyoshi Suga
The objective of this study was to investigate the distribution of 11C-methionine (MET) and F-18 fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) imaging and the hyperintense area in T2 weighted imaging (T2WI) in glioma with no or poor gadolinium enhancement in magnetic resonance imaging (GdMRI). Cases were also analyzed pathologically. We prospectively investigated 16 patients with non- or minimally enhancing (< 10% volume) glioma. All patients underwent MET-PET and FDG-PET scans preoperatively...
March 7, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29515794/appropriate-magnetic-resonance-imaging-techniques-for-gross-tumor-volume-delineation-in-external-beam-radiation-therapy-of-locally-advanced-cervical-cancer
#20
Yingqiu Song, Beth Erickson, Xiaojian Chen, Guiling Li, Gang Wu, Eric Paulson, Paul Knechtges, X Allen Li
Background: Accurate delineation of the gross tumor volumes (GTV) is a prerequisite for precise radiotherapy planning and delivery. Different MRI sequences have different advantages and limitations in their ability to discriminate primary cervical tumor from normal tissue. The purpose of this work is to determine appropriate MRI techniques for GTV delineation for external-beam radiation therapy of locally advanced cervical cancer (LACC). Materials and Methods: GTVs were delineated on the MRI, CT, and PET images acquired for 23 LACC patients in treatment positions to obtain GTVs on CT (GTV-CT), on various MRI sequences including T1 (GTV-T1), T2 (GTV-T2), T1 with fat suppression and contrast (GTV-T1F+), DWI-ADC (GTV-ADC) and on PET were generated using the threshold of 40% of maximum SUV (GTV-SUV40%) as well as SUV of 2...
February 9, 2018: Oncotarget
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