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https://www.readbyqxmd.com/read/28323641/metal-artifacts-in-computed-tomography-for-radiation-therapy-planning-dosimetric-effects-and-impact-of-metal-artifact-reduction
#1
Drosoula Giantsoudi, Bruno De Man, Joost Verburg, Alexei Trofimov, Yannan Jin, Ge Wang, Lars Gjesteby, Harald Paganetti
A significant and increasing number of patients receiving radiation therapy present with metal objects close to, or even within, the treatment area, resulting in artifacts in computed tomography (CT) imaging, which is the most commonly used imaging method for treatment planning in radiation therapy. In the presence of metal implants, such as dental fillings in treatment of head-and-neck tumors, spinal stabilization implants in spinal or paraspinal treatment or hip replacements in prostate cancer treatments, the extreme photon absorption by the metal object leads to prominent image artifacts...
March 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28320428/a-topology-based-method-to-mitigate-the-dosimetric-uncertainty-caused-by-the-positional-variation-of-the-boost-volume-in-breast-conservative-radiotherapy
#2
Peng-Yi Lee, Chih-Yuan Lin, Shang-Wen Chen, Chun-Ru Chien, Chun-Nan Chu, Hsiu-Ting Hsu, Ji-An Liang, Ying-Jun Lin, An-Cheng Shiau
BACKGROUND: To improve local control rate in patients with breast cancer receiving adjuvant radiotherapy after breast conservative surgery, additional boost dose to the tumor bed could be delivered simultaneously via the simultaneous integrated boost (SIB) modulated technique. However, the position of tumor bed kept changing during the treatment course as the treatment position was aligned to bony anatomy. This study aimed to analyze the positional uncertainties between bony anatomy and tumor bed, and a topology-based approach was derived to stratify patients with high variation in tumor bed localization...
March 20, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28300381/comparison-of-ct-images-with-average-intensity-projection-free-breathing-and-mid-ventilation-for-dose-calculation-in-lung-cancer
#3
Chirasak Khamfongkhruea, Sangutid Thongsawad, Chirapha Tannanonta, Sasikarn Chamchod
The purpose of this study was to compare three computed tomography (CT) images under different conditions-average intensity projection (AIP), free breathing (FB), mid-ventilation (MidV)-used for radiotherapy contouring and planning in lung cancer patients. Two image sets derived from four-dimensional CT (4DCT) acquisition (AIP and MidV) and three-dimensional CT with FB were generated and used to plan for 29 lung cancer patients. Organs at risk (OARs) were delineated for each image. AIP images were calculated with 3D conformal radiotherapy (3DCRT) and intensity-modulated radiation therapy (IMRT)...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297341/assessment-of-monte-carlo-algorithm-for-compliance-with-rtog-0915-dosimetric-criteria-in-peripheral-lung-cancer-patients-treated-with-stereotactic-body-radiotherapy
#4
Damodar Pokhrel, Sumit Sood, Rajeev Badkul, Hongyu Jiang, Christopher McClinton, Christopher Lominska, Parvesh Kumar, Fen Wang
The purpose of the study was to evaluate Monte Carlo-generated dose distributions with the X-ray Voxel Monte Carlo (XVMC) algorithm in the treatment of peripheral lung cancer patients using stereotactic body radiotherapy (SBRT) with non-protocol dose-volume normalization and to assess plan outcomes utilizing RTOG 0915 dosimetric compliance criteria. The Radiation Therapy Oncology Group (RTOG) protocols for non-small cell lung cancer (NSCLC) currently require radiation dose to be calculated using tissue density heterogeneity corrections...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297292/a-comprehensive-evaluation-of-adaptive-daily-planning-for-cervical-cancer-hdr-brachytherapy
#5
Rebecca Meerschaert, Adrian Nalichowski, Jay Burmeister, Arun Paul, Steven Miller, Zhenghui Hu, Ling Zhuang
The purpose of this study was to evaluate adaptive daily planning for cervical cancer patients who underwent high-dose-rate intracavitary brachytherapy (HDR-BT) using comprehensive interfractional organ motion measurements. This study included 22 cervical cancer patients who underwent 5 fractions of HDR-BT. Regions of interest (ROIs) including high-risk clinical tumor volume (HR-CTV) and organs at risk (OARs) were manually contoured on daily CT images. All patients were clinically treated with adaptive daily plans (ADP), which involved ROI delineation and dose optimization at each treatment fraction...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28293971/a-modeling-study-of-functional-magnetic-resonance-imaging-to-individualize-target-definition-of-seminal-vesicles-for-external-beam-radiotherapy
#6
Sidsel Damkjær, Jakob B Thomsen, Svetlana I Petersen, Jens Peter Bangsgaard, Peter M Petersen, Ivan R Vogelius, Marianne C Aznar
BACKGROUND: Pre-treatment magnetic resonance imaging (MRI) can give patient-specific evaluation of suspected pathologically involved volumes in the seminal vesicles (SV) in prostate cancer patients. By targeting this suspicious volume we hypothesize that radiotherapy is more efficient without introducing more toxicity. In this study we evaluate the concept of using MRI-defined target volumes in terms of tumor control probability (TCP) and rectal normal tissue complication probability (NTCP)...
March 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28284495/planning-study-for-merkel-cell-carcinoma-based-on-the-relapse-pattern
#7
Ulrike Hoeller, Tina Schubert, Thomas Mueller, Volker Budach, Pirus Ghadjar, Winfried Brenner, Wolf Kuschke
PURPOSE: To develop a technique for radiation (RT) of in-transit path ways (IT) in Merkel cell carcinoma. METHOD: In the planning study, IT were ink-marked on the skin during sentinel lymphscintigraphy and wire-marked in planning-CT. Pre- and post-operative planning-CTs were acquired. The clinical target volume (CTV) included tumor bed plus safety margin, IT and draining nodes, the planning volume (PTV) the CTV plus 0.5-1cm margin. VMAT plans with 2-3 arcs were analyzed...
March 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28263422/correlation-between-fluorodeoxyglucose-hotspots-on-pretreatment-positron-emission-tomography-ct-and-preferential-sites-of-local-relapse-after-chemoradiotherapy-for-head-and-neck-squamous-cell-carcinoma
#8
Anne Chaput, Jérémie Calais, Philippe Robin, Sébastien Thureau, David Bourhis, Romain Modzelewski, Ulrike Schick, Pierre Vera, Pierre-Yves Salaün, Ronan Abgral
BACKGROUND: The potential benefits of (18) F-fluoro-2-deoxy-D-glucose-positron emission tomography/CT (FDG-PET/CT) imaging for radiotherapy (RT) treatment planning of head and neck squamous cell carcinoma (HNSCC) are increasingly being recognized. It has been suggested that intratumoral subvolumes with high FDG avidity ("hotspots") are potential targets for selected dose escalation. The purposes of this study were to demonstrate that pre-RT FDG-PET/CT can identify intratumoral sites at increased risk of local relapse after RT and to determine an optimal threshold to delineate smaller RT target volumes that would facilitate RT dose escalation without impaired tolerance...
March 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28259450/modality-specific-target-definition-for-laryngeal-and-hypopharyngeal-cancer-on-fdg-pet-ct-and-mri
#9
Hans Ligtenberg, Elise Anne Jager, Joana Caldas-Magalhaes, Tim Schakel, Frank A Pameijer, Nicolien Kasperts, Stefan M Willems, Chris H J Terhaard, Cornelis P J Raaijmakers, Marielle E P Philippens
BACKGROUND AND PURPOSE: The goal of this study was to improve target definition by deriving modality-specific margins for clinical target volumes (CTV) for laryngeal and hypopharyngeal cancer on CT, MRI and 18-FDG-PET. MATERIAL AND METHODS: Twenty-five patients with T3/T4 laryngeal/hypopharyngeal cancer underwent CT, MRI and 18-FDG-PET scans before laryngectomy. HE-sections were obtained from the surgical specimen and tumor was delineated (tumorHE). The GTVs on CT and MRI were delineated in consensus...
March 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28252445/comparing-the-dosimetric-impact-of-interfractional-anatomical-changes-in-photon-proton-and-carbon-ion-radiotherapy-for-pancreatic-cancer-patients
#10
Antonetta C Houweling, Koen Crama, Jorrit Visser, Kyohei Fukata, Coen R N Rasch, Tatsuya Ohno, Arjan Bel, Astrid van der Horst
Radiotherapy using charged particles is characterized by a low dose to the surrounding healthy organs, while delivering a high dose to the tumor. However, interfractional anatomical changes can greatly affect the robustness of particle therapy. Therefore, we compared the dosimetric impact of interfractional anatomical changes (i.e. body contour differences and gastrointestinal gas volume changes) in photon, proton and carbon ion therapy for pancreatic cancer patients. In this retrospective planning study, photon, proton and carbon ion treatment plans were created for 9 patients...
March 2, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28229077/surgical-therapy-of-cholangiocarcinoma
#11
REVIEW
Arnold Radtke, Alfred Königsrainer
BACKGROUND: The majority of patients with cholangiocarcinoma present with advanced disease that is often challenging to diagnose and to treat. The optimal preoperative evaluation requires a coordinated multidisciplinary approach. Surgical resection is the mainstay of therapy. METHODS: This systematic review delineates surgical treatment strategies for cholangiocarcinoma in general as well as special considerations concerning the particular tumor localization. A literature search (see keywords) was conducted using PubMed and publications between 1990 and 2016 regarding resectable and advanced cholangiocarcinoma were reviewed...
December 2016: Visceral Medicine
https://www.readbyqxmd.com/read/28225485/magnetic-resonance-mr-imaging-for-tumor-staging-and-definition-of-tumor-volumes-on-radiation-treatment-planning-in-nonsmall-cell-lung-cancer-a-prospective-radiographic-cohort-study-of-single-center-clinical-outcome
#12
COMPARATIVE STUDY
Dan Zhao, Qiaoqiao Hu, Liping Qi, Juan Wang, Hao Wu, Guangying Zhu, Huiming Yu
We investigate the impact of magnetic resonance (MR) on the staging and radiotherapy planning for patients with nonsmall cell lung cancer (NSCLC).A total of 24 patients with NSCLC underwent MRI, which was fused with radiotherapy planning CT using rigid registration. Gross tumor volume (GTV) was delineated not only according to CT image alone (GTVCT), but also based on both CT and MR image (GTVCT/MR). For each patient, 2 conformal treatment plans were made according to GTVCT and GTVCT/MR, respectively. Dose-volume histograms (DVH) for lesion and normal organs were generated using both GTVCT and GTVCT/MR treatment plans...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28197025/current-perioperative-management-of-pheochromocytomas
#13
REVIEW
Rashmi Ramachandran, Vimi Rewari
Neuroendocrine tumors which have the potential to secrete catecholamines are either associated with sympathetic adrenal (pheochromocytoma) or nonadrenal (paraganglioma) tissue. Surgical removal of these tumors is always indicated to cure and prevent cardiovascular and other organ system complications associated with catecholamine excess. Some of these tumors have malignant potential as well. The diagnosis, localization and anatomical delineation of these tumors involve measurement of catecholamines and their metabolic end products in plasma and urine, (123)I-metaiodobenzylguanidine scintigraphy, computed tomography, and/or magnetic resonance imaging...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28196288/clinical-adequacy-assessment-of-auto-contours-for-prostate-imrt-with-meaningful-endpoints
#14
Hamidreza Nourzadeh, William T Watkins, Mahmoud Ahmad, Cheukkai Hui, David Schlesinger, Jeffrey V Siebers
PURPOSE: To determine if radiation treatment plans created based on auto-segmented (AS) regions-of-interest (ROI)s are clinically equivalent to plans created based on manually segmented ROIs, where equivalence is evaluated using probabilistic dosimetric metrics and probabilistic biological endpoints for prostate IMRT. METHOD AND MATERIALS: Manually drawn contours and auto-segmented ROIs were created for 167 CT image sets acquired from 19 prostate patients. Auto-segmentation was performed utilizing Pinnacle's Smart Probabilistic Image Contouring Engine...
February 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/28194632/characterization-of-an-orthotopic-colorectal-cancer-mouse-model-and-its-feasibility-for-accurate-quantification-in-positron-emission-tomography
#15
Sara Rapic, Christel Vangestel, Jeroen Verhaeghe, Tim Van den Wyngaert, Rukun Hinz, Marleen Verhoye, Patrick Pauwels, Steven Staelens, Sigrid Stroobants
PURPOSE: Quantification in positron emission tomography (PET) imaging of an orthotopic mouse model of colorectal cancer (CRC) is challenging due to difficult tumor delineation. We aimed to establish a reproducible delineation approach, evaluate its feasibility for reliable PET quantification and compare its added translational value with its subcutaneous counterpart. PROCEDURES: A subcutaneous Colo205-luc2 tumor fragment harvested from a donor mouse was transplanted onto the caecum of nude mice, with (n = 10) or without (n = 10) the addition of an X-ray detectable thread...
February 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28181819/dose-escalation-study-with-respiratory-gated-carbon-ion-scanning-radiotherapy-using-a-simultaneous-integrated-boost-for-pancreatic-cancer-simulation-with-four-dimensional-computed-tomography
#16
Shohei Kawashiro, Shinichiro Mori, Shigeru Yamada, Kentaro Miki, Kenji Nemoto, Hiroshi Tsuji, Tadashi Kamada
OBJECTIVE: Pancreatic cancer is a difficult to treat disease with a persistently high mortality rate. We evaluated dose distribution simulation with respiratory-gated carbon-ion pencil beam scanning (C-PBS) with a simultaneous integrated boost (SIB) to increase tumour dose, sparing organs at risk (OARs). METHODS: Using four-dimensional CT data of 12 patients, we delineated gross tumour volume and two clinical target volumes (CTVs). To consider beam range intrafractional uncertainty, we calculated field-specific target volumes, from which two planning target volumes (PTVs) were generated...
April 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28179345/correlation-of-tumor-and-peritumoral-edema-volumes-with-survival-in-patients-with-cerebral-metastases
#17
Johannes Kerschbaumer, Marlies Bauer, Marina Popovscaia, Astrid E Grams, Claudius Thomé, Christian F Freyschlag
BACKGROUND: Surgical resection in combination with radiotherapy in selected cases remains the best option for patients with cerebral metastases. Postoperative relapse of brain metastases occurs frequently and can be reduced by postoperative whole-brain radiotherapy (WBRT). Continuous spread of tumor cells from the primary lesions is debated as a cause of recurrence. It is well known that in gliomas, infiltration takes place within the surrounding edema. Obviously, most brain metastases are usually associated with peritumoral edema, which may act as an indicator of infiltration and more aggressive tumor biology...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28168166/evaluation-of-pet-mri-for-tumor-volume-delineation-for-head-and-neck-cancer
#18
Kyle Wang, Brandon T Mullins, Aaron D Falchook, Jun Lian, Kelei He, Dinggang Shen, Michael Dance, Weili Lin, Tiffany M Sills, Shiva K Das, Benjamin Y Huang, Bhishamjit S Chera
INTRODUCTION: Computed tomography (CT), combined positron emitted tomography and CT (PET/CT), and magnetic resonance imaging (MRI) are commonly used in head and neck radiation planning. Hybrid PET/MRI has garnered attention for potential added value in cancer staging and treatment planning. Herein, we compare PET/MRI vs. planning CT for head and neck cancer gross tumor volume (GTV) delineation. MATERIAL AND METHODS: We prospectively enrolled patients with head and neck cancer treated with definitive chemoradiation to 60-70 Gy using IMRT...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28160039/measuring-the-apparent-diffusion-coefficient-in-primary-rectal-tumors-is-there-a-benefit-in-performing-histogram-analyses
#19
Miriam M van Heeswijk, Doenja M J Lambregts, Monique Maas, Max J Lahaye, Z Ayas, Jos M G M Slenter, Geerard L Beets, Frans C H Bakers, Regina G H Beets-Tan
PURPOSE: The apparent diffusion coefficient (ADC) is a potential prognostic imaging marker in rectal cancer. Typically, mean ADC values are used, derived from precise manual whole-volume tumor delineations by experts. The aim was first to explore whether non-precise circular delineation combined with histogram analysis can be a less cumbersome alternative to acquire similar ADC measurements and second to explore whether histogram analyses provide additional prognostic information. METHODS: Thirty-seven patients who underwent a primary staging MRI including diffusion-weighted imaging (DWI; b0, 25, 50, 100, 500, 1000; 1...
February 3, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28144116/a-method-to-obtain-correct-standard-uptake-values-in-pinnacle-treatment-planning-system-for-target-volume-delineation
#20
Farshid Salehzahi, Jason Tse, Jonathan Lee, Jothybasu Selvaraj
Standardized uptake value (SUV) is an advanced tool for quantitative tumor identification and metabolic target volume delineation (TVD) in diagnostic and therapeutic settings. It is thus important to establish a quality assured process to maintain the traceability of data correctly by positron emission tomography (PET) systems. Patient administration of (18)fluoro-deoxy-glucose is increasingly delivered by automated infusion systems (AISs). Whenever AIS is used, its accuracy and traceability measurement need verification...
October 2016: Journal of Medical Physics
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