Qian Yang, Maria Carolina Borges, Eleanor Sanderson, Maria C Magnus, Fanny Kilpi, Paul J Collings, Ana Luiza Soares, Jane West, Per Magnus, John Wright, Siri E Håberg, Kate Tilling, Deborah A Lawlor
BACKGROUND: Insomnia is common and associated with adverse pregnancy and perinatal outcomes in observational studies. However, those associations could be vulnerable to residual confounding or reverse causality. Our aim was to estimate the association of insomnia with stillbirth, miscarriage, gestational diabetes (GD), hypertensive disorders of pregnancy (HDP), perinatal depression, preterm birth (PTB), and low/high offspring birthweight (LBW/HBW). METHODS AND FINDINGS: We used 2-sample mendelian randomization (MR) with 81 single-nucleotide polymorphisms (SNPs) instrumenting for a lifelong predisposition to insomnia...
September 6, 2022: PLoS Medicine