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JOURNAL ARTICLE
Sarina K Butzer, Kirstin Faust, André Oberthuer, Charlotte Kleindiek, Benjamin Kuehne, Christoph Haertel, Katrin Mehler
PURPOSE: Very low birth weight (VLBW) infants are at a risk of spontaneous focal intestinal perforation (FIP). Treatment includes supportive care, antibiotics, and drainage with/without surgery. Broad-spectrum antibiotic agents like carbapenems are applied frequently, although their use is not well-supported by the limited evidence of causal pathogens. We hypothesize that the use of carbapenems may not be necessary in VLBW infants with FIP. Our primary objective was to evaluate the antimicrobial use in VLBW infants with FIP in a cohort of the German Neonatal Network (GNN)...
April 18, 2024: Infection
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JOURNAL ARTICLE
Rupin Kumar, Sherry L Kausch, Angela K S Gummadi, Karen D Fairchild, Mayuresh M Abhyankar, William A Petri, Brynne A Sullivan
BACKGROUND: Early diagnosis of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) in very low birth weight (VLBW, <1,500 g) infants is challenging due to non-specific clinical signs. Inflammatory biomarkers increase in response to infection, but non-infectious conditions also cause inflammation. Cardiorespiratory data contain physiological biomarkers, or physiomarkers, of sepsis that may be useful in combination with inflammatory hematologic biomarkers for sepsis diagnosis...
2024: Frontiers in Pediatrics
#3
JOURNAL ARTICLE
Grace O Adeniyi-Ipadeola, Kristi L Hoffman, Heeju Yang, Sara J Javornik Cregeen, Geoffrey A Preidis, Sasirekha Ramani, Amy B Hair
BACKGROUND: In very low birth weight (VLBW) infants, human milk cream added to standard human milk fortification is used to improve growth. This study aimed to evaluate the impact of cream supplement on the intestinal microbiome of VLBW infants. METHODS: Whole genome shotgun sequencing was performed on stool (n = 57) collected from a cohort of 23 infants weighing 500-1250 grams (control = 12, cream = 11). Both groups received an exclusive human milk diet (mother's own milk, donor human milk, and donor human milk-derived fortifier) with the cream group receiving an additional 2 kcal/oz cream at 100 mL/kg/day of fortified feeds and then 4 kcal/oz if poor growth...
January 16, 2024: Pediatric Research
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JOURNAL ARTICLE
Sophie J Jansen, Shole D L Broer, Marieke A C Hemels, Douwe H Visser, Tim A J Antonius, Ilja E Heijting, Klasien A Bergman, Jacqueline U M Termote, Matthias C Hütten, Jacqueline P F van der Sluijs, Esther J d'Haens, René F Kornelisse, Enrico Lopriore, Vincent Bekker
BACKGROUND: The establishment of an epidemiological overview provides valuable insights needed for the (future) dissemination of infection-prevention initiatives. AIM: To describe the nation-wide epidemiology of central-line associated bloodstream infections (CLABSI) among Dutch Neonatal Intensive Care Units (NICUs). METHODS: Data from 2,935 neonates born <32 weeks' gestation and/or with a birth weight <1,500 grams admitted to all 9 Dutch NICUs over a two-year surveillance period (2019-2020) were analysed...
December 14, 2023: Journal of Hospital Infection
#5
JOURNAL ARTICLE
Ryo Itoshima, Arata Oda, Ryo Ogawa, Toshimitsu Yanagisawa, Takehiko Hiroma, Tomohiko Nakamura
BACKGROUND: In infants born weighing ≤500 g, little has been studied about the association between neurodevelopmental prognosis and growth. This study aimed to evaluate the association between neurodevelopmental impairment (NDI) and z-scores of physical measurements in infants born weighing ≤500 g. METHODS: A single-center, retrospective cohort study in a level IV neonatal intensive care unit in Japan. Infants born weighing ≤500 g between 2010 and 2019 were eligible...
2023: Pediatrics International: Official Journal of the Japan Pediatric Society
#6
JOURNAL ARTICLE
Keisuke Yoshii, Naho Morisaki, Aurélie Piedvache, Shinya Nakada, Kazuhiko Arima, Kiyoshi Aoyagi, Hiroki Nakashima, Nobufumi Yasuda, Isao Muraki, Kazumasa Yamagishi, Isao Saito, Tadahiro Kato, Kozo Tanno, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane, Norie Sawada
BACKGROUND: An association between birth weight and cardiovascular disease (CVD) in adulthood has been observed in many countries; however, only a few studies have been conducted in Asian populations. METHODS: We used data from the baseline survey (2011-2016) of the Japan Public Health Center-based Prospective Study for the Next Generation Cohort, which included 114,105 participants aged 40-74 years. Adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were calculated from the prevalence of present and past histories of CVD and other lifestyle-related diseases, including hypertension, diabetes, hyperlipidemia, and gout, by birth weight, using Poisson regression...
November 18, 2023: Journal of Epidemiology
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JOURNAL ARTICLE
Bikila Regassa Feyisa, Yosef Mulatu, Firehiwot Fentahun, Bayise Biru, Evan Atlantis
BACKGROUND: Low Birth Weight (LBW) remains a major public health concern globally, especially in lower and middle-income countries. In Ethiopia in general and in the study area in particular there is limited evidence regarding maternal factors associated with low birth weight. This study aimed to identify the maternal factors associated with low birth weight among neonates born in public health facilities in the west Wollega zone, West Ethiopia. METHODS: We used a case-control study design and selected participant mothers with a newborn using the delivery database from three public hospitals and five health centers, between March 2022 and April 2022...
2023: Frontiers in Public Health
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JOURNAL ARTICLE
George O Agogo, Jennifer R Verani, Nancy A Otieno, Bryan O Nyawanda, Marc-Alain Widdowson, Sandra S Chaves
INTRODUCTION: Measurement error in gestational age (GA) may bias the association of GA with a health outcome. Ultrasound-based GA is considered the gold standard and is not readily available in low-resource settings. We corrected for measurement error in GA based on fundal height (FH) and date of last menstrual period (LMP) using ultrasound from the sub-cohort and adjusted for the bias in associating GA with neonatal mortality and low birth weight (< 2,500 grams, LBW). METHODS: We used data collected from 01/2015 to 09/2019 from pregnant women enrolled at two public hospitals in Siaya county, Kenya ( N = 2,750)...
2023: Frontiers in Medicine
#9
JOURNAL ARTICLE
Luca Maria Pesando, Komin Qiyomiddin
There is increasing evidence that digital technologies such as mobile phones have the potential to shape some of the United Nations (UN) Sustainable Development Goals (SDGs) such as health, education, and nutrition, even among the most resource-deprived countries and communities in the world. Nonetheless, little research has focused on the intergenerational implications of digital technologies for infant health and wellbeing. This study leverages Demographic and Health Survey (DHS) data from 29 low- and middle-income countries (LMICs) to explore associations between mothers' ownership of mobile phones and their children's health at birth, as measured by birth weight and low birth weight (LBW), i...
2023: PloS One
#10
JOURNAL ARTICLE
José Ramón Jiménez-Jiménez, Jose Alfredo Sierra-Ramírez, Rodolfo Rivas-Ruiz, Leonardo Cruz-Reynoso, Marta Elena Hernández-Caballero
Background Adequate nutritional support is crucial for achieving optimal growth and development in very-low-birth-weight (VLBW) preterm infants. This study evaluated the efficacy of combined nutrition (CN) (parenteral plus enteral nutrition (EN)) as an alternative nutrition protocol for VLBW infants in the neonatal intensive care unit (NICU). Methods This retrospective cohort study collected clinical and growth data from the medical records of VLBW infants weighing between 1,000 and 1,500 grams in the NICU of the Hospital of Obstetrics and Gynecology "Dr...
August 2023: Curēus
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JOURNAL ARTICLE
Priyanka Gaur, Kristin C Darwin, Jaden R Kohn, Katelyn Uribe, Ernie Shippey, Ahizechukwu Eke
BACKGROUND: Despite findings that maternal COVID-19 infection in pregnancy is associated with low birth weight (LBW; weight < 2,500 grams), previous studies demonstrate no difference in LBW risk between COVID-19 vaccinated and unvaccinated pregnant persons. Few studies, however, have examined the association of unvaccinated, incomplete, and complete vaccination on LBW, and they have been limited by small sample sizes and lack of adjustment for covariates. OBJECTIVE: We sought to address key limitations of prior work and evaluate this association between unvaccinated, incomplete, and complete COVID-19 vaccination status in pregnancy and LBW...
June 15, 2023: American journal of obstetrics & gynecology MFM
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JOURNAL ARTICLE
Baek Sup Shin, Seung Han Shin, Seul Gi Park, Ee-Kyung Kim, Han-Suk Kim
BACKGROUND: Vancomycin (VCM) is a widely used antibiotic for the treatment of gram-positive microorganisms, with some nephrotoxic effects. Recent studies have suggested that piperacillin-tazobactam (TZP) aggravates VCM-induced nephrotoxicity in adults and adolescents. However, there is a lack of research investigating these effects in the newborn population. Therefore, this study investigates whether the concomitant use of TZP with VCM use increases the risk of acute kidney injury (AKI) and to explore the factors associated with AKI in preterm infants treated with VCM...
June 16, 2023: BMC Pediatrics
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JOURNAL ARTICLE
Neal J Russell, Wolfgang Stöhr, Nishad Plakkal, Aislinn Cook, James A Berkley, Bethou Adhisivam, Ramesh Agarwal, Nawshad Uddin Ahmed, Manica Balasegaram, Daynia Ballot, Adrie Bekker, Eitan Naaman Berezin, Davide Bilardi, Suppawat Boonkasidecha, Cristina G Carvalheiro, Neema Chami, Suman Chaurasia, Sara Chiurchiu, Viviane Rinaldi Favarin Colas, Simon Cousens, Tim R Cressey, Ana Carolina Dantas de Assis, Tran Minh Dien, Yijun Ding, Nguyen Trong Dung, Han Dong, Angela Dramowski, Madhusudhan Ds, Ajay Dudeja, Jinxing Feng, Youri Glupczynski, Srishti Goel, Herman Goossens, Doan Thi Huong Hao, Mahmudul Islam Khan, Tatiana Munera Huertas, Mohammad Shahidul Islam, Daniel Jarovsky, Nathalie Khavessian, Meera Khorana, Angeliki Kontou, Tomislav Kostyanev, Premsak Laoyookhon, Sorasak Lochindarat, Mattias Larsson, Maia De Luca, Surbhi Malhotra-Kumar, Nivedita Mondal, Nitu Mundhra, Philippa Musoke, Marisa M Mussi-Pinhata, Ruchi Nanavati, Firdose Nakwa, Sushma Nangia, Jolly Nankunda, Alessandra Nardone, Borna Nyaoke, Christina W Obiero, Maxensia Owor, Wang Ping, Kanchana Preedisripipat, Shamim Qazi, Lifeng Qi, Tanusha Ramdin, Amy Riddell, Lorenza Romani, Praewpan Roysuwan, Robin Saggers, Emmanuel Roilides, Samir K Saha, Kosmas Sarafidis, Valerie Tusubira, Reenu Thomas, Sithembiso Velaphi, Tuba Vilken, Xiaojiao Wang, Yajuan Wang, Yonghong Yang, Liu Zunjie, Sally Ellis, Julia A Bielicki, A Sarah Walker, Paul T Heath, Mike Sharland
BACKGROUND: There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predicting mortality in neonatal sepsis to inform future clinical trial design. METHODS AND FINDINGS: Hospitalized infants <60 days with clinical sepsis were enrolled during 2018 to 2020 by 19 sites in 11 countries (mainly Asia and Africa)...
June 2023: PLoS Medicine
#14
JOURNAL ARTICLE
Katherine A Gallaway, Kayla Cann, Katherine Oetting, Mary Rothenberger, Andra Raibulet, James E Slaven, Kristen Suhrie, Emma M Tillman
OBJECTIVE: To evaluate the use of drugs with pharmacogenomic (PGx) guidelines from the Clinical Pharmacogenetics Implementation Consortium (CPIC) in early childhood. STUDY DESIGN: A retrospective observational study of neonatal intensive care (NICU) patients admitted between 2005 - 2018 with at least one subsequent hospitalization at or after 5 years of age was performed to determine PGx-drug exposure. Data regarding hospitalizations, drug exposures, gestational age, birth weight, and congenital anomalies and/or a primary genetic diagnosis were collected...
May 16, 2023: Journal of Pediatrics
#15
JOURNAL ARTICLE
Ludmila Gerios, Victor H B Rodrigues, José E Corrente, João C Lyra, Ligia M S S Rugolo, Maria R Bentlin
OBJECTIVES: This study aimed to assess the incidence of late-onset sepsis (LOS), associated risk factors, and short-term prognosis in very low birth weight (VLBW) infants in a 10-year period. STUDY DESIGN: A cohort study was conducted with 752 VLBW preterm infants-23 to 33 gestational weeks and 400 to 1,500 g birth weight-admitted to a neonatal intensive care unit from 2008 to 2017 and who survived over 72 hours. LOS was defined as clinical and laboratory signs of infection, whether or not confirmed by blood culture...
May 11, 2023: American Journal of Perinatology
#16
JOURNAL ARTICLE
Kimberly L Parra, Robin B Harris, Leslie V Farland, Paloma Beamer, Melissa Furlong
OBJECTIVE: To examine fetal growth outcomes from agricultural worker households. METHODS: Using Arizona 2006-2013 birth certificates with parental occupation, we identified N = 623,185 live births by agricultural household status. Logistic regression models estimated adjusted Odds Ratios (aOR) for macrosomia (>4,000 grams), postterm birth (>41 weeks), low birth weight (LBW <2,500 grams), pre-term birth (PTB <37 weeks), large-for-gestational-age (LGA), small-for-gestational-age (SGA), and 5 min-APGAR (<7)...
May 9, 2023: Journal of Occupational and Environmental Medicine
#17
JOURNAL ARTICLE
Nadine Scholten, Alicia Fitzgerald, Katja Matthias, Mi-Ran Okumu, Tim Ohnhäuser, Katharina Schmitz, Christine Schreiner, Isabella Schwab, Anna Stirner, Ricarda Wullenkord, Till Dresbach
INTRODUCTION: Mother's own milk is the best nutrition for every newborn and especially for vulnerable infants such as preterm infants with a very low birth weight below 1,500 grams (VLBW). If no MOM is available, human donor milk is the alternative of choice. Mothers of preterm born infants face challenging conditions that impair sufficient milk production. For this reason, it is particularly important to provide structural lactation support and, at the same time, to promote the establishment of human donor milk banks...
2023: PloS One
#18
JOURNAL ARTICLE
Andrea V Margulis, Brian Calingaert, Alison T Kawai, Elena Rivero-Ferrer, Mary S Anthony
PURPOSE: We aimed to describe the distribution of gestational age at birth (GAB) to inform the estimation of GAB when clinical or obstetric estimates are not available for perinatal pharmacoepidemiology studies. METHODS: We estimated GAB (median, mode, mean, standard deviation) and percentage born at each gestational week in groups based on plurality and other variables for live births in CDC's US birth data. RESULTS: In 2020, 3,617,213 newborns had birth certificates with nonmissing GAB...
April 17, 2023: Pharmacoepidemiology and Drug Safety
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JOURNAL ARTICLE
Cristiane Valéria Batista Pereira Abdo, Camila Gonçalves Miranda Shimoya Belém, Enrico Antonio Colosimo, Maria Cândida Ferrarez Bouzada Viana, Ivani Novato Silva
OBJECTIVE: To investigate, at school age, the metabolic profile of children born preterm. METHODS: A cross-sectional study of children 5 to 8 years old, born with gestational age (GA) < 34 weeks and/or weight ≤ 1,500 grams. Clinical and anthropometric data were assessed by a single trained pediatrician. Biochemical measurements were done at the organization's Central Laboratory using standard methods. Data on health conditions, eating, and daily life habits were retrieved from medical charts and through validated questionnaires...
April 12, 2023: Jornal de Pediatria
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JOURNAL ARTICLE
Rebecca A Gourevitch, Laura A Hatfield
OBJECTIVE: To evaluate whether the expansion of Federally Qualified Health Centers (FQHCs) improved late prenatal care initiation, low birth weight, and preterm birth among Medicaid-covered or uninsured individuals. DATA SOURCES AND STUDY SETTING: We identified all FQHCs in California using the Health Resources and Services Administration's Uniform Data System from 2000 to 2019. We used data from the U.S. Census American Community Survey to describe area characteristics...
November 7, 2022: Health Services Research
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