keyword
MENU ▼
Read by QxMD icon Read
search

mechanical induction

keyword
https://www.readbyqxmd.com/read/29909290/induction-of-redd1-via-ap-1-prevents-oxidative-stress-mediated-injury-in-hepatocytes
#1
Sam Seok Cho, Kyu Min Kim, Ji Hye Yang, Ji Young Kim, Su Jung Park, Seung Jung Kim, Jae Kwang Kim, Il Je Cho, Sung Hwan Ki
Regulated in development and DNA damage responses 1 (REDD1) is an inducible gene in response to various stresses, which functions as a negative regulator of the mammalian target of rapamycin protein kinase in complex 1. In the present study, we identified the role of REDD1 under the oxidative stress-mediated hepatocyte injury and its regulatory mechanism. REDD1 protein was increased in H2 O2 or tert-butylhydroperoxide (t-BHP)-treated hepatocytes. H2 O2 also elevated REDD1 mRNA levels. This event was inhibited by antioxidants such as diphenyleneiodonium chloride, N-acetyl-L-cysteine, or butylated hydroxy anisole...
June 14, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29909236/antiepileptic-drugs-as-analgesics-adjuvants-in-inflammatory-pain-current-preclinical-evidence
#2
REVIEW
Tomić Maja, Pecikoza Uroš, Micov Ana, Vučković Sonja, Stepanović-Petrović Radica
Inflammatory pain is the most common type of pain that is treated clinically. The use of currently available treatments (classic analgesics - NSAIDs, paracetamol and opioids) is limited by insufficient efficacy and/or side effects/tolerance development. Antiepileptic drugs (AEDs) are widely used in neuropathic pain treatment, but there is substantial preclinical evidence on their efficacy against inflammatory pain, too. In this review we focus on gabapentinoids (gabapentin and pregabalin) and dibenzazepine AEDs (carbamazepine, oxcarbazepine, and recently introduced eslicarbazepine acetate) and their potential for relieving inflammatory pain...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29909233/phenotype-analyses-of-il-10-producing-foxp3-cd4-t-cells-increased-by-subcutaneous-immunotherapy-in-allergic-airway-inflammation
#3
Masaya Matsuda, Yuki Morie, Hirotaka Oze, Kana Doi, Tatsuya Tsutsumi, Junpei Hamaguchi, Miki Inaba, Takeshi Nabe
INTRODUCTION: The mechanisms of allergen immunotherapy are not fully elucidated. Here, we sought to develop a murine model to demonstrate the effectiveness of subcutaneous immunotherapy (SCIT) for allergic responses. As excessive antigen dosages may induce immune tolerance in sensitized mice, the effects of SCIT were assessed by varying the antigen dosage. The mechanisms of SCIT were analyzed by focusing on the induction of Foxp3+ Treg cells and IL-10-producing Foxp3- CD4+ T cells, as well as on the phenotype of the latter cells...
June 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29909064/development-of-the-astyanax-mexicanus-circadian-clock-and-non-visual-light-responses
#4
Inga A Frøland Steindal, Andrew Beale, Yoshiyuki Yamamoto, David Whitmore
Most animals and plants live on the planet exposed to periods of rhythmic light and dark. As such, they have evolved endogenous circadian clocks to regulate their physiology rhythmically, and non-visual light detection mechanisms to set the clock to the environmental light-dark cycle. In the case of fish, circadian pacemakers are not only present in the majority of tissues and cells, but these tissues are themselves directly light-sensitive, expressing a wide range of opsin photopigments. This broad non-visual light sensitivity exists to set the clock, but also impacts a wide range of fundamental cell biological processes, such as DNA repair regulation...
June 14, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29908986/hydroquinone-exposure-worsens-the-symptomatology-of-rheumatoid-arthritis
#5
Cintia Scucuglia Heluany, Leonard de Vinci Kanda Kupa, Mariana Nascimento Viana, Cristina Maria Fernandes, Sandra Helena Poliselli Farsky
The genesis of rheumatoid arthritis (RA) is complex and dependent on genetic background and exposure to environmental xenobiotic. Indeed, smoking is associated to developing and worsening pre-existing RA. Nevertheless, the mechanisms and cigarette compounds involved in the harmful processes have not been elucidated. Here, we investigated if the exposure to hydroquinone (HQ), an abundant pro-oxidative compound of cigarette and benzene metabolite, could worsen the ongoing RA. Hence, collagen-induced arthritis (CIA) was induced in male Wistar rats by s...
June 14, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29908495/phytol-shows-anti-angiogenic-activity-and-induces-apoptosis-in-a549-cells-by-depolarizing-the-mitochondrial-membrane-potential
#6
Ravi Sakthivel, Dicson Sheeja Malar, Kasi Pandima Devi
In the present study, the antiproliferative activity of phytol and its mechanism of action against human lung adenocarcinoma cell line A549 were studied in detail. Results showed that phytol exhibited potent antiproliferative activity against A549 cells in a dose and time-dependent manner with an IC50 value of 70.81 ± 0.32 μM and 60.7 ± 0.47 μM at 24 and 48 h, respectively. Phytol showed no adverse toxic effect in normal human lung cells (L-132), but mild toxic effect was observed when treated with maximum dose (67 and 84 μM)...
June 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29908368/tag-synthesis-and-storage-under-osmotic-stress-a-requirement-for-preserving-membrane-homeostasis-in-renal-cells
#7
Karen Weber, Cecilia Casali, Virginia Gaveglio, Susana Pasquaré, Emanuel Morel Gómez, Leandro Parra, Luciana Erjavec, Cecilia Perazzo, María C Fernández Tome
Hyperosmolarity is a controversial signal for renal cells. It can induce cell stress or differentiation and both require an active lipid metabolism. We showed that hyperosmolarity upregulates phospholipid (PL) de novo synthesis in renal cells. PL synthesis requires fatty acids (FA), usually stored as triglycerides (TAG). PL and TAG de novo synthesis utilize the same initial biosynthetic route: sn-glycerol 3P (G3P) → phosphatidic acid (PA) → diacylglycerol (DAG). In the present work, we evaluate how such pathway contributes to PL and TAG synthesis in renal cells subjected to hyperosmolarity...
June 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29908224/implication-of-surgical-procedure-in-the-induction-of-headache-and-generalized-painful-sensation-in-a-fluid-percussion-injury-model-in-rats
#8
Fernando da SilvaFiorin, Caroline Cunha do Espírito Santo, Adair Roberto Soares Santos, Michele Rechia Fighera, Luiz Fernando Freire Royes
BACKGROUND: This study demonstrated the effects of traumatic brain injury (TBI) and each step of the surgical procedure for a fluid percussion injury (FPI) model on periorbital allodynia. NEW METHOD: Adult male Wistar rats were divided in naive, incision, scraping, sham-TBI and TBI groups. Periorbital allodynia was evaluated using von Frey filaments, and heat hyperalgesia of the hindpaws was evaluated by a Plantar Test Apparatus. RESULTS: The statistical analyses revealed that the surgical procedure decreased von Frey filaments thresholds twenty-four hours after the surgery in all groups when compared to the naive group (p < 0...
June 13, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29908199/establishment-of-a-cell-model-of-x-linked-sideroblastic-anemia-using-genome-editing
#9
Kiriko Kaneko, Yoshiko Kubota, Kazumi Nomura, Haruka Hayashimoto, Taisei Chida, Naoto Yoshino, Marina Wayama, Katsutoshi Ogasawara, Yukio Nakamura, Ikuo Tooyama, Kazumichi Furuyama
ALAS2 gene mutations cause X-linked sideroblastic anemia. The presence of ring sideroblasts in a patient's bone marrow is the hallmark of sideroblastic anemia, but the precise mechanisms underlying sideroblast formation are largely unknown. Using a genome editing system, a mutation was introduced in the erythroid-specific enhancer of the ALAS2 gene in HUDEP2 cells, which were derived from human umbilical stem cells and can produce erythrocytes. The established cell line, termed HA2low, expressed less ALAS2 mRNA than did wild-type cells, even after erythroid differentiation...
June 13, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29908087/scotostimulation-of-reproductive-neural-pathways-and-gonadal-maturation-are-not-correlated-with-hypothalamic-expression-of-deiodinases-in-subtropical-spotted-munia
#10
Ila Mishra, Neha Agarwal, Sangeeta Rani, Vinod Kumar
Circannual rhythm regulates annual timing of reproduction in spotted munia, with sex-differences in its relationship with the external photoperiod environment. Interestingly, munia show an atypical photosensitivity and exhibit gonadal maturation when acutely exposed to an unnatural short photoperiod (e.g. 3 h light per day; i.e. a long scotoperiod). The proximate mechanisms regulating scotoperiod-induced hypothalamus-pituitary-gonadal (HPG) activation are unclear. Since thyroid hormone signalling plays a central role in photoperiodic induction, we hypothesized the involvement of similar mechanism, i...
June 16, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29908082/the-role-of-sigma-1-receptor-in-sex-specific-heat-shock-response-in-an-experimental-rat-model-of-renal-ischemia-reperfusion-injury
#11
Adam Hosszu, Zsuzsanna Antal, Apor Veres-Szekely, Lilla Lenart, Dora Bianka Balogh, Edgar Szkibinszkij, Lilla Illesy, Judit Hodrea, Nora F Banki, Laszlo Wagner, Adam Vannay, Attila J Szabo, Andrea Fekete
We previously showed that female rats are more protected against renal ischemia/reperfusion (I/R) injury than males, which is partly attributed to their more pronounced heat shock response. We recently described that Sigma-1 receptor (S1R) activation improves postischemic survival and renal function. 17β-estradiol activates S1R, thus here we investigated the role of sex-specific S1R activation and heat shock response in severe renal I/R injury. Proximal tubular cells were treated with 17β-estradiol, which caused direct S1R activation and subsequent induction of heat shock response...
June 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29907857/alterations-of-mtor-signaling-impact-metabolic-stress-resistance-in-colorectal-carcinomas-with-braf-and-kras-mutations
#12
Raphaela Fritsche-Guenther, Christin Zasada, Guido Mastrobuoni, Nadine Royla, Roman Rainer, Florian Roßner, Matthias Pietzke, Edda Klipp, Christine Sers, Stefan Kempa
Metabolic reprogramming is as a hallmark of cancer, and several studies have reported that BRAF and KRAS tumors may be accompanied by a deregulation of cellular metabolism. We investigated how BRAFV600E and KRASG12V affect cell metabolism, stress resistance and signaling in colorectal carcinoma cells driven by these mutations. KRASG12V expressing cells are characterized by the induction of glycolysis, accumulation of lactic acid and sensitivity to glycolytic inhibition. Notably mathematical modelling confirmed the critical role of MCT1 designating the survival of KRASG12V cells...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907771/mir-30-disrupts-senescence-and-promotes-cancer-by-targeting-both-p16-ink4a-and-dna-damage-pathways
#13
Weijun Su, Lixin Hong, Xin Xu, Shan Huang, Denise Herpai, Lisheng Li, Yingxi Xu, Lan Truong, Wen-Yuan Hu, Xiaohua Wu, Changchun Xiao, Wei Zhang, Jiahuai Han, Waldemar Debinski, Rong Xiang, Peiqing Sun
miR-30 is a microRNA frequently overexpressed in human cancers. However, the biological consequence of miR-30 overexpression in cancer has been unclear. In a genetic screen, miR-30 was found to abrogate oncogenic-induced senescence, a key tumor-suppressing mechanism that involves DNA damage responses, activation of p53 and induction of p16INK4A . In cells and mouse models, miR-30 disrupts senescence and promotes cancer by suppressing 2 targets, CHD7 and TNRC6A. We show that while CHD7 is a transcriptional coactivator essential for induction of p16INK4A in senescent cells, TNRC6A, a miRNA machinery component, is required for expression and functionality of DNA damage response RNAs (DDRNAs) that mediate DNA damage responses and p53 activation by orchestrating histone modifications, chromatin remodeling and recruitment of DNA damage factors at damaged sites...
June 15, 2018: Oncogene
https://www.readbyqxmd.com/read/29907758/mechanism-of-neuroprotection-by-trehalose-controversy-surrounding-autophagy-induction
#14
He-Jin Lee, Ye-Seul Yoon, Seung-Jae Lee
Trehalose is a non-reducing disaccharide with two glucose molecules linked through an α, α-1,1-glucosidic bond. Trehalose has received attention for the past few decades for its role in neuroprotection especially in animal models of various neurodegenerative diseases, such as Parkinson and Huntington diseases. The mechanism underlying the neuroprotective effects of trehalose remains elusive. The prevailing hypothesis is that trehalose protects neurons by inducing autophagy, thereby clearing protein aggregates...
June 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29907755/molecular-chaperoning-helps-safeguarding-mitochondrial-integrity-and-motor-functions-in-the-sahara-silver-ant-cataglyphis-bombycina
#15
Quentin Willot, Patrick Mardulyn, Matthieu Defrance, Cyril Gueydan, Serge Aron
The Sahara silver ant Cataglyphis bombycina is one of the world's most thermotolerant animals. Workers forage for heat-stricken arthropods during the hottest part of the day, when temperatures exceed 50 °C. However, the physiological adaptations needed to cope with such harsh conditions remain poorly studied in this desert species. Using transcriptomics, we screened for the most heat-responsive transcripts of C. bombycina with aim to better characterize the molecular mechanisms involved with macromolecular stability and cell survival to heat-stress...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907707/-leishmania-donovani-exploits-tollip-a-multitasking-protein-to-impair-tlr-il-1r-signaling-for-its-survival-in-the-host
#16
Naveen Parmar, Pragya Chandrakar, Preeti Vishwakarma, Kavita Singh, Kalyan Mitra, Susanta Kar
IL-1R/TLR signaling plays a significant role in sensing harmful foreign pathogens and mounting effective innate and adaptive immune responses. However, the precise mechanism by which Leishmania donovani, an obligate intramacrophagic pathogen, breaches IL-1R/TLR signaling and host-protective immunity remains obscure. In this study, we report the novel biphasic role of Toll-interacting protein (Tollip), a negative regulator of the IL-1R/TLR pathway, in the disease progression of experimental visceral leishmaniasis...
June 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29907679/the-tumour-suppressor-opcml-promotes-axl-inactivation-by-the-phosphatase-ptprg-in-ovarian-cancer
#17
Jane Antony, Elisa Zanini, Zoe Kelly, Tuan Zea Tan, Evdoxia Karali, Mohammad Alomary, Youngrock Jung, Katherine Nixon, Paula Cunnea, Christina Fotopoulou, Andrew Paterson, Sushmita Roy-Nawathe, Gordon B Mills, Ruby Yun-Ju Huang, Jean Paul Thiery, Hani Gabra, Chiara Recchi
In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI-anchored tumour suppressor OPCML Further, we demonstrate that AXL directly interacts with OPCML, preferentially so when AXL is activated by its ligand Gas6. As a consequence, AXL accumulates in cholesterol-rich lipid domains, where OPCML resides. Here, phospho-AXL is brought in proximity to the lipid domain-restricted phosphatase PTPRG, which de-phosphorylates the RTK/ligand complex...
June 15, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29907566/the-role-of-glycolysis-derived-hexose-phosphates-in-the-induction-of-the-crabtree-effect
#18
Mónica Rosas Lemus, Elodie Roussarie, Noureddine Hammad, Alexis Mougeolle, Stéphane Ransac, Razanne Issa, Jean-Pierre Mazat, Salvador Uribe-Carvajal, Michel Rigoulet, Anne Devin
Evidence for the Crabtree effect was first reported by H. Crabtree in 1929 and is defined as the glucose-induced decrease of cellular respiratory flux. This effect was observed in tumor cells and was not detected in most non-tumor cells. A number of hypotheses on the mechanism underlying the Crabtree effect have been formulated. However, to this day, no consensual mechanism for this effect has been described. In a previous study on isolated mitochondria, we have proposed that fructose-1,6-bisphosphate (F1,6bP), which inhibits the respiratory chain, induces the Crabtree effect...
June 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29907375/fndc5-expression-in-purkinje-neurons-of-adult-male-rats-with-acute-spinal-cord-injury-following-treatment-with-methylprednisolone
#19
Sajad Hassanzadeh, Seyed Behnamedin Jameie, Mehdi Mehdizadeh, Mansooreh Soleimani, Zeinab Namjoo, Maryam Soleimani
Spinal cord injury (SCI) is a serious and complex medical condition that can happen to anyone. At present, therapy mainly focuses on rehabilitation and pharmacological treatment, such as methylprednisolone (MP). Supra-spinal changes in certain structures, such as the cerebellum, that receive many afferents from the spinal cord might be one reason for unsuccessful therapeutic outcomes. Recently, the expression of FNDC5 was reported in cerebellar Purkinje cells as a possible neuroprotective agent. In the present study, we considered the expression of FNDC5 in Purkinje cells following SCI with and without MP administration in adult rats with SCI...
May 7, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29906774/2-3-butanediol-activated-disease-resistance-of-creeping-bentgrass-by-inducing-phytohormone-and-antioxidant-responses
#20
Yi Shi, Xinju Liu, Yuanyuan Fang, Qing Tian, Hanyu Jiang, Huiling Ma
Brown patch, caused by Rhizoctonia solani, is a serious disease in Agrostis stolonifera. 2, 3-butanediol (2, 3-BD) is the major component of volatile organic compounds and was found to initiate induced systemic resistance (ISR). To investigate the induced resistance mechanism of 2, 3-BD, we examined the effects of resistance by area affected, along with changes in the content of phytohormones (Zeatin (ZT), Abscisic Acid (ABA) and Indole-3-Acetic Acid (IAA)), the activities of three phenylpropanoid metabolic enzymes (Phenylalaninammo-Nialyase (PAL), Chalcone Isomerase (CHI) and 4-Coumarate:Coenzyme A Ligase (4CL)) and the level of secondary metabolites (total phenols, flavonoid and lignin)...
June 12, 2018: Plant Physiology and Biochemistry: PPB
keyword
keyword
58233
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"