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https://www.readbyqxmd.com/read/28888674/geographical-variations-in-clinical-presentation-and-outcomes-of-decompressive-surgery-in-patients-with-symptomatic-degenerative-cervical-myelopathy-analysis-of-a-prospective-international-multicenter-cohort-study-of-757-patients
#1
Michael G Fehlings, Branko Kopjar, Ahmed Ibrahim, Lindsay A Tetreault, Paul M Arnold, Helton Defino, Shashank Sharad Kale, S Tim Yoon, Giuseppe M Barbagallo, Ronald H M Bartels, Qiang Zhou, Alexander R Vaccaro, Mehmet Zileli, Gamaliel Tan, Yasutsugu Yukawa, Darrel S Brodke, Christopher I Shaffrey, Osmar Santos de Moraes, Eric J Woodard, Massimo Scerrati, Masato Tanaka, Tomoaki Toyone, Rick C Sasso, Michael E Janssen, Ziya L Gokaslan, Manuel Alvarado, Ciaran Bolger, Christopher M Bono, Mark B Dekutoski
BACKGROUND CONTEXT: Degenerative cervical myelopathy (DCM) is a progressive degenerative spine disease and the most common cause of spinal cord impairment in adults worldwide. There is a paucity of studies reporting on regional variations in demographics, clinical presentation, disease causation and surgical effectiveness. PURPOSE: To evaluate differences in demographics, causative pathology, management strategies, surgical outcomes, length of hospital stay and complications across four geographic regions...
September 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28888024/airflow-and-symptom-outcomes-between-allergic-and-non-allergic-rhinitis-patients-from-turbinoplasty
#2
K Parthasarathi, J M Christensen, R Alvarado, H P Barham, R Sacks, R J Harvey
BACKGROUND: Inferior turbinate procedures are applied to relieve medically refractory nasal obstruction. However, the nature of congestion differs between allergic(AR) and non-allergic rhinitis(NAR). This study compares surgical outcomes between AR and NAR patients. METHODOLOGY: A case-control study of patients undergoing turbinate with or without septoplasty surgery for nasal obstruction was performed. Patient reported outcomes were: nasal obstruction, global nasal function(GNF), and sino-nasal outcome test(SNOT-22) with rhinitis, facial symptom, sleep and psychological sub-scores...
September 9, 2017: Rhinology
https://www.readbyqxmd.com/read/28887605/the-possible-protective-effect-of-marital-status-in-quality-of-life-among-elders-in-a-u-s-mexico-border-city
#3
Marisela Gutiérrez-Vega, Oscar Armando Esparza-Del Villar, Irene Concepción Carrillo-Saucedo, Priscila Montañez-Alvarado
The purpose of this study was to determine how marital status may have an impact on quality of life in a group of older adults living in a U.S.-Mexico border city. Two-hundred and seventy-six older adults completed the Spanish version of the World Health Organization Quality of Life Assessment, composed of four domains: physical health, psychological health, social relationships, and environment. Participants answered a measure of sociodemographic variables. In the psychological health component of quality of life, single and married older adults had the highest scores as compared to widowed and divorced...
September 8, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28876141/utility-of-soluble-triggering-receptor-expressed-on-myeloid-cells-1-strem-1-as-biomarker-to-predict-therapeutic-response-to-methotrexate-in-rheumatoid-arthritis
#4
Jorge I Gamez-Nava, David Bonilla-Lara, Juan M Ponce-Guarneros, J Alejandro Zuñiga-Mora, Edsaul E Perez-Guerrero, Jessica D Murillo-Vazquez, Itzel N Becerra-Alvarado, N Alejandra Rodriguez-Jimenez, A Miriam Saldaña-Cruz, M Luisa Vazquez-Villegas, Erika Y Vera-Navarrete, Fabiola Gonzalez-Ponce, Laura Gonzalez-Lopez
The objective of this study was to investigate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in predicting short-term therapeutic response to methotrexate (MTX) in rheumatoid arthritis (RA). Patients with active RA, with Disease Activity Score-28 joints (DAS-28) >3.2, starting oral MTX, were included. We measured at baseline, 3 and 6 mo: DAS-28, Health Assessment Questionnaire-Disability Index (HAQ-DI), patient's perception of disease severity, morning stiffness and pain, as well as modifications in sTREM-1 levels...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28846723/habitat-quality-affects-the-incidence-of-morphological-abnormalities-in-the-endangered-salamander-ambystoma-ordinarium
#5
Carlos Soto-Rojas, Ireri Suazo-Ortuño, José Arturo Montoya Laos, Javier Alvarado-Díaz
Identification of early warning signals previous to the occurrence of population decline or extinction is a major challenge for the conservation of animal species. Prevalence of morphological abnormalities in a population can be one of these signals. We registered morphological abnormalities in the salamander Ambystoma ordinarium. We also evaluated the relation between habitat quality and the prevalence of abnormalities in this species. We used scores from rapid bioassessment protocols (RBPs) to assess the habitat quality of streams inhabited by A...
2017: PloS One
https://www.readbyqxmd.com/read/28833159/best-practices-for-multidisciplinary-integration-of-a-dcis-genomic-assay-into-clinical-practice
#6
Michael Alvarado, Anthony Lucci, Jennifer Manders
Most newly diagnosed ductal carcinoma in situ (DCIS) is treated with breast-conserving surgery (BCS) ± radiation therapy (RT). A key challenge is deciding whether or not to include RT with BCS. This decision is often determined by the degree of risk associated with disease recurrence. However, methods for risk assessment have not kept pace with diagnostic advances. The DCIS Score is an independent predictor and quantifier of individualized recurrence risk in patients with DCIS. Although the test is the only available genomic classifier for DCIS, the degree of adoption is varied, and it has not yet been fully accepted as standard practice...
August 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28774880/a-randomized-phase-ii-study-of-low-dose-decitabine-versus-low-dose-azacitidine-in-lower-risk-mds-and-mds-mpn
#7
Elias Jabbour, Nicholas J Short, Guillermo Montalban-Bravo, Xuelin Huang, Carlos Bueso-Ramos, Wei Qiao, Hui Yang, Chong Zhao, Tapan Kadia, Gautam Borthakur, Naveen Pemmaraju, Koji Sasaki, Zeev Estrov, Jorge Cortes, Farhad Ravandi, Yesid Alvarado, Rami Komrokji, Mikkael A Sekeres, David P Steensma, Amy DeZern, Gail Roboz, Hagop Kantarjian, Guillermo Garcia-Manero
BACKGROUND: Hypomethylating agents (HMAs) improve survival in patients with higher-risk myelodysplastic syndromes (MDS) but are less well-studied in lower-risk disease. We compared the safety and efficacy of low-dose decitabine versus low-dose azacitidine in this group of patients. METHODS: Adults with low- or intermediate-1-risk MDS or MDS/myeloproliferative neoplasm (MPN), including chronic myelomonocytic leukemia, by the International Prognostic Scoring System were randomized using a Bayesian adaptive design to receive either azacitidine 75 mg/m(2) IV/SC daily or decitabine 20 mg/m(2) IV daily for 3 consecutive days on a 28-day cycle...
August 3, 2017: Blood
https://www.readbyqxmd.com/read/28755908/communication-skills-in-candidates-for-accreditation-in-rheumatology-are-correlated-with-candidate-s-performance-in-the-objective-structured-clinical-examination
#8
Virginia Pascual-Ramos, Diana Elsa Flores-Alvarado, Margarita Portela-Hernández, María Del Rocío Maldonado-Velázquez, Luis Manuel Amezcua-Guerra, Judith López-Zepeda, Everardo Álvarez, Nadina Rubio, Olga Vera Lastra, Miguel Ángel Saavedra, César Alejandro Arce-Salinas
BACKGROUND: The Mexican Accreditation Council for Rheumatology annually certifies trainees in Rheumatology using a multiple-choice test and an objective structured clinical examination (OSCE). Since 2015, candidate's communication skills (CS) have been rated by both patients and by physician examiners and correlated with results on the OSCE. This study compared the CS from candidates to annual accreditation in Rheumatology as rated by patients and by physician examiners, and assessed whether these correlated with candidate's performance in the OSCE...
July 26, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28738954/the-utility-of-the-alvarado-score-in-the-diagnosis-of-acute-appendicitis-in-the-elderly
#9
Anastasiya Shchatsko, Rebecca Brown, Trista Reid, Sasha Adams, Amy Alger, Anthony Charles
Clinical scores determining the likelihood of acute appendicitis (AA), including the Alvarado score, were devised using a younger population, and their efficacy in predicting AA in elderly patients is not well documented. This study's purpose is to evaluate the utility of Alvarado scores in this population. A retrospective chart review of patients >65 years old presenting with pathologically diagnosed AA from 2000 to 2010 was performed. Ninety-six patients met inclusion criteria. The average age was 73.7 ± 1...
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28714072/survival-of-patients-with-cirrhosis-and-acute-peptic-ulcer-bleeding-compared-with-variceal-bleeding-using-current-first-line-therapies
#10
Alba Ardevol, Gemma Ibañez-Sanz, Joaquim Profitos, Carles Aracil, Josep M Castellvi, Edilmar Alvarado, Alba Cachero, Diana Horta, Josep Miñana, Bárbara Gomez-Pastrana, Oana Pavel, Eva Dueñas, Meritxell Casas, Montserrat Planella, Jose Castellote J, Candid Villanueva
The presence of cirrhosis increases the mortality of patients with peptic ulcer bleeding (PUB). Both acute variceal bleeding (AVB) and PUB are associated with substantial mortality in cirrhosis. This multicenter cohort study was performed to assess whether the mortality of cirrhotic patients with PUB is different from that of those with AVB. Patients with cirrhosis and acute gastrointestinal bleeding were consecutively included and treated with somatostatin and PPI infusion from admission and with antibiotic prophylaxis...
July 17, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28661313/acute-appendicitis-after-kidney-transplantation-experience-at-a-tertiary-care-hospital-in-mexico-city
#11
Edgar Ortiz-Brizuela, Alejandro Quiroz-Compeán, Mario Vilatobá-Chapa, Josefina Alberú-Gómez
OBJECTIVES: Here, we describe the presentation, treatment, and outcomes of acute appendicitis in kidney transplant recipients at a tertiary care hospital in Mexico City. MATERIALS AND METHODS: We conducted a retrospective case series study at a tertiary care hospital in Mexico City from January 2000 to January 2015. RESULTS: During our study period, 1186 patients received a kidney transplant; among these patients, we identified 10 cases of acute appendicitis (0...
June 28, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28648469/long-term-clinical-outcomes-following-radiofrequency-and-microwave-ablation-of-renal-cell-carcinoma-at-a-single-va-medical-center
#12
Salim E Abboud, Tanay Patel, Stephanie Soriano, Joseph Giesler, Nannette Alvarado, Preet Kang
PURPOSE: Microwave ablation (MWA) is a relatively newer treatment modality for treatment of renal cell carcinoma (RCC), and only a few small studies have examined the short- and long-term outcomes for MWA applied to renal tumors. The purpose of this retrospective review is to assess the initial experience including technical short- and long-term success rates of using radiofrequency ablation (RFA) and MWA for RCC at a single Veterans Affairs (VA) medical center. MATERIALS AND METHODS: Tumor characteristics were recorded using the R...
May 17, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28573428/a-retrospective-evaluation-of-the-modified-alvarado-score-for-the-diagnosis-of-acute-appendicitis-in-hiv-infected-patients
#13
S Sobnach, C Ede, G Van Der Linde, J Klopper, S Thomson, A Bhyat, D Kahn
BACKGROUND: The aim of this study was to evaluate and compare the diagnostic value of a Modified Alvarado Score (MAS) ≥7 for acute appendicitis in both Human Immunodeficiency Virus (HIV)-negative (HIVneg) and positive (HIVpos) patientcohorts. METHODS: This retrospective study included all HIV-tested patients undergoing appendectomy at a regional hospital from March 2010 to March 2011. The MAS was calculated for all patients, as well as for the HIVneg and HIVpos groups separately...
June 1, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28559857/spanish-adaptation-and-validation-of-the-outcome-questionnaire-oq-30-2
#14
Paula Errázuriz, Sebastián Opazo, Alex Behn, Oscar Silva, Sergio Gloger
This study assessed the psychometric properties of a Spanish version of the Shortened Outcome Questionnaire (OQ-30.2, Lambert et al., 2004) validated with a sample of 546 patients in an outpatient mental health clinic and 100 non-clinical adults in Chile. Our results show that this measure has similar normative data to the original measure, with a cutoff score for the Chilean population set at 43.36, and the reliable change index at 14. This Spanish OQ-30.2 has good internal consistency (α = 0.90), has concurrent validity with the Depressive, Anxious, and Somatoform disorders measuring scale (Alvarado and Vera, 1991), and is sensitive to change during psychotherapy...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28548309/tau-%C3%AE-synuclein-ratio-and-inflammatory-proteins-in-parkinson-s-disease-an-exploratory-study
#15
Manuel Delgado-Alvarado, Belén Gago, Ana Gorostidi, Haritz Jiménez-Urbieta, Rosalía Dacosta-Aguayo, Irene Navalpotro-Gómez, Javier Ruiz-Martínez, Alberto Bergareche, José F Martí-Massó, Pablo Martínez-Lage, Andrea Izagirre, María C Rodríguez-Oroz
BACKGROUND: No CSF or plasma biomarker has been validated for diagnosis or progression of PD. OBJECTIVES: To assess whether the CSF and plasma levels of proteins associated with PD neuropathological inclusions and with neuroinflammation might have value in the diagnosis of PD or in relation to disease severity. METHODS: CSF levels of α-synuclein, amyloid-ß1-42, total tau, and threonine-181 phosphorylated tau, as well as CSF and plasma levels of cytokines (interleukin-1ß, interleukin-2, interleukin, interferon-γ, and tumor necrosis factor α) were studied in 40 PD patients and 40 healthy controls...
July 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28530770/diagnostic-value-of-appendicular-doppler-ultrasonography-in-acute-appendicitis
#16
Hüseyin Uzunosmanoğlu, Yunsur Çevik, Şeref Kerem Çorbacıoğlu, Emine Akıncı, Hakan Buluş, Kadir Ağladıoğlu
BACKGROUND: Acute appendicitis is one of the most common causes of acute abdominal pain prompting emergency department (ED) visits. It is critical for the physicians to promptly and accurately diagnose acute appendicitis. The present study aimed to evaluate the diagnostic efficacy of Doppler ultrasonography (USG) in patients with acute appendicitis and compare this new method with other commonly used radio-diagnostic tools. METHODS: All patients who were diagnosed with acute appendicitis at the Kecioren Training and Research Hospital ED and later underwent appendectomy between October 2012 and April 2013 were included in the study...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28492221/accuracy-of-modified-alvarado-score-eskelinen-score-and-ohmann-score-in-diagnosing-acute-appendicitis
#17
Pejana Rastović, Zoran Trninić, Gordan Galić, Zdrinko Brekalo, Josip Lesko, Marko Pavlović
INTRODUCTION: By processing the data of a large number of patients with abdominal pain, diagnostic scores whose implementation attempts to facilitate acute appendicitis diagnostics were developed. Modified Alvarado score, Ohmann score and Eskelinen score are used as assistance when setting the diagnosis and making a decision to undertake surgery. AIM: To assess accuracy of Alvarado score, Ohmann score and Eskelinen score in diagnosing acute appendicitis and to establish connection of total score of these scoring systems with histopathological degree of appendicitis...
May 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28489170/modified-alvarado-score-in-children-with-diagnosis-of-appendicitis
#18
Mehran Peyvasteh, Shahnam Askarpour, Hazhir Javaherizadeh, Sepideh Besharati
Background: Appendicitis is one of the most common abdominal emergency. Some predictive scoring systems are recommended to decrease the rate of negative appendectomy. Aim: To evaluate sensitivity, specificity, positive predictive value, and negative predictive value of modified Alvarado score in children who underwent appendectomy. Methods: Four hundred children with initial diagnosis of appendicitis were randomly selected from patients who underwent appendectomy...
January 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28486303/how-reliable-is-alvarado-score-and-its-subgroups-in-ruling-out-acute-appendicitis-and-suggesting-the-opportunity-of-nonoperative-management-or-surgery
#19
Salomone Di Saverio, Arianna Birindelli, Alice Piccinini, Fausto Catena, Andrea Biscardi, Gregorio Tugnoli
No abstract text is available yet for this article.
June 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28459797/a-highly-sensitive-and-specific-combined-clinical-and-sonographic-score-to-diagnose-appendicitis
#20
Swathi B Reddy, Michael Kelleher, S A Jamal Bokhari, Kimberly A Davis, Kevin M Schuster
BACKGROUND: CT scanning reduces the negative appendectomy rate however it exposes the patient to ionizing radiation. Ultrasound (US) does not carry this risk but may be non-diagnostic. We hypothesized that a clinical-ultrasound scoring system would improve diagnostic accuracy. METHODS: We conducted a retrospective review of all patients (>15 yo) who presented through the emergency department with suspected appendicitis and underwent initial US. An ultrasound score was developed using odds ratios for appendicitis given appendiceal diameter, compressibility, hyperemia, free fluid and focal or diffuse tenderness...
April 28, 2017: Journal of Trauma and Acute Care Surgery
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