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JOURNAL ARTICLE
Angélica Valencia, Carlos Viñals, Elsa Alvarado, Marcela Balderas, Joëlle Provasi
INTRODUCTION: Prechtl's method (GMA) is a test for the functional assessment of the young nervous system. It involves a global and a detailed assessment of the general movements (GMs) and has demonstrated validity. Data on the reliability of both assessments in the preterm period are scarce. This study aimed to evaluate the inter-rater reliability for the global and detailed assessments of the preterm writhing GMA. MATERIALS AND METHODS: The study participants were 69 infants born at <37 gestational weeks and admitted to the neonatal intensive care unit...
2024: PloS One
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JOURNAL ARTICLE
Ali Mansour, Plamena P Powla, Ronald Alvarado-Dyer, Farima Fakhri, Paramita Das, Peleg Horowitz, Fernando D Goldenberg, Christos Lazaridis
Traumatic brain injury (TBI) is a global health challenge; however, penetrating brain injury (PBI) remains under-represented in evidence-based knowledge and research efforts. This study utilized data from the Trauma Quality Improvement Program (TQIP) of the National Trauma Data Bank (NTDB) to investigate outcomes of PBI as compared with clinical-severity-matched non-penetrating or blunt TBI. A total of 1765 patients with PBI were 1:1 propensity score-matched for clinical severity with blunt TBI patients. The intent of PBI was self-inflicted in 34...
2024: Neurotrauma reports
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JOURNAL ARTICLE
Virginia McKay, Yichen Chen, Kim Prewitt, Sara Malone, Maria Puerto-Torres, Carlos Acuña-Aguirre, Yvania Alfonso-Carreras, Shilel Y Alvarez-Arellano, Leticia A Andrade-Sarmiento, Daniela Arce-Cabrera, Deiby Argüello-Vargas, Mariuxy D C Barragán-García, Rosario Batista-Del-Cid, Erika E Blasco-Arriaga, Maria D C Cach-Castaneda, Gloria I Ceballo-Batista, Mayra Chávez-Rios, Maria E Costa, Maria E Cuencio-Rodriguez, Rosdali Diaz-Coronado, Ever A Fing-Soto, Teresa D J García-Sarmiento, Wendy C Gómez-García, Cinthia J Hernández-González, Yajaira V Jimenez-Antolinez, Maria S Juarez-Tobias, Esmeralda M León-López, Norma A Lopez-Facundo, Ruth A Martínez Soria, Scheybi T Miralda-Méndez, Erika Montalvo, Carlos M Pérez-Alvarado, Clara K Perez-Fermin, Monica L Quijano-Lievano, Beatriz Salas-Mendoza, Edwin E Sanchez-Fuentes, Marcia X Serrano-Landivar, Veronica Soto-Chavez, Isidoro Tejocote-Romero, Sergio Valle, Elizabeth A Vasquez-Roman, Juliana Texeira Costa, Adolfo Cardenas-Aguirre, Meenakshi Devidas, Douglas A Luke, Asya Agulnik
Clinical capacity for sustainability, or the clinical resources needed to sustain an evidence-based practice, represent proximal determinants that contribute to intervention sustainment. We examine the relationship between clinical capacity for sustainability and sustainment of PEWS, an evidence-based intervention to improve outcomes for pediatric oncology patients in resource-variable hospitals. We conducted a cross-sectional survey among Latin American pediatric oncology centers participating in Proyecto Escala de Valoración de Alerta Temprana (EVAT), an improvement collaborative to implement Pediatric Early Warning Systems (PEWS)...
March 2024: Glob Implement Res Appl
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JOURNAL ARTICLE
Stefano Agnesi, Gabriele Mauro Di Lucca, Fabio Benedetti, Luca Fattori, Luca Degrate, Linda Roccamatisi, Marco Braga, Marco Ceresoli
Appendicitis is one of the most common abdominal emergencies. Evidence is controversial in determining if the in-hospital time delay to surgery can worsen the clinical presentation of appendicitis. This study aimed to clarify if in-hospital surgical delay significantly affected the proportion of complicated appendicitis in a large prospective cohort of patients treated with appendectomy for acute appendicitis. Patients were grouped into low, medium, and high preoperative risk for acute appendicitis based on the Alvarado scoring system...
April 2, 2024: Updates in Surgery
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JOURNAL ARTICLE
Aditya Subramanian, Babapelumi Adejuyigbe, Kian Niknam, Francisco Gomez-Alvarado, Saam Morshed, David Shearer
PURPOSE: There is high burden of long bone fractures in low- and middle-income countries (LMICs). Given a limited availability of fluoroscopy in LMICs, the Surgical Implant Generation Network (SIGN) developed two types of intramedullary nails: the SIGN standard nail and the SIGN Fin Nail. A limited number of studies have analyzed healing outcomes with the SIGN Fin Nail and the current study is the largest one to date. The purpose of this study is to compare outcomes between the SIGN standard nail and SIGN Fin Nails in adult femoral shaft fractures treated with a retrograde approach...
August 2024: Journal of Orthopaedics
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JOURNAL ARTICLE
Chloe N Matovina, Allie Sakowicz, Emma C Allen, Mayán I Alvarado-Goldberg, Danielle Millan, Emily S Miller
BACKGROUND: Postpartum depression affects 10-20% of birthing people and is associated with changes in healthcare utilization. Little is known about the association between postpartum depressive symptoms and choice to use contraception, however both un- or under-treated depression and short interpregnancy intervals pose significant perinatal health risks. OBJECTIVE: To evaluate whether postpartum depressive symptoms are associated with changes in decisions to use any method of contraception...
March 27, 2024: American Journal of Obstetrics and Gynecology
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JOURNAL ARTICLE
Federico Coccolini, Aleix Martinez-Perez, Gabriella Licitra, Nicola De Angelis, Camilla Cremonini, Silvia Strambi, Giuseppe Zocco, Adolfo Puglisi, Dario Tartaglia, Massimo Chiarugi
BACKGROUND: Controversies remain on the diagnostic strategy in suspected AA, considering the different settings worldwide. MATERIAL AND METHODS: A prospective observational international multicentric study including patients operated for suspected AA with a definitive histopathological analysis was conducted. Three groups were analyzed: (1) No radiology; (2) Ultrasound, and (3) Computed tomography. The aim was to analyze the performance of three diagnostic schemes...
March 28, 2024: World Journal of Surgery
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JOURNAL ARTICLE
Rimsha Anam, Muhammad Waqas Anwar, Muhammad Hasan Jamal, Usama Ijaz Bajwa, Isabel de la Torre Diez, Eduardo Silva Alvarado, Emmanuel Soriano Flores, Imran Ashraf
Named Entity Recognition (NER) is a natural language processing task that has been widely explored for different languages in the recent decade but is still an under-researched area for the Urdu language due to its rich morphology and language complexities. Existing state-of-the-art studies on Urdu NER use various deep-learning approaches through automatic feature selection using word embeddings. This paper presents a deep learning approach for Urdu NER that harnesses FastText and Floret word embeddings to capture the contextual information of words by considering the surrounding context of words for improved feature extraction...
2024: PloS One
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JOURNAL ARTICLE
Patricia Reis Wolfertstetter, John Blanford Ebert, Judith Barop, Markus Denzinger, Michael Kertai, Hans J Schlitt, Christian Knorr
BACKGROUND: Simple appendicitis may be self-limiting or require antibiotic treatment or appendectomy. The aim of this study was to assess the feasibility and safety of a nonoperative, antibiotic-free approach for suspected simple appendicitis in children. METHODS: This single-center, retrospective study included patients (0-17 years old) who were hospitalized at the pediatric surgery department due to suspected appendicitis between 2011 and 2012. Data from patients who primarily underwent appendectomy were used as controls...
March 13, 2024: Children
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JOURNAL ARTICLE
Gal Ben Haim, Adi Braun, Haggai Eden, Livnat Burshtein, Yiftach Barash, Avinoah Irony, Eyal Klang
BACKGROUND AND AIMS: Artificial Intelligence (AI) models like GPT-3.5 and GPT-4 have shown promise across various domains but remain underexplored in healthcare. Emergency Departments (ED) rely on established scoring systems, such as NIHSS and HEART score, to guide clinical decision-making. This study aims to evaluate the proficiency of GPT-3.5 and GPT-4 against experienced ED physicians in calculating five commonly used medical scores. METHODS: This retrospective study analyzed data from 150 patients who visited the ED over one week...
May 2024: American Journal of Emergency Medicine
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JOURNAL ARTICLE
Jorge Luis Ramírez-Melo, Daniel C Moreira, Ana Luisa Orozco-Alvarado, Fernando Sánchez-Zubieta, Regina M Navarro-Martín Del Campo
INTRODUCTION: Patients with optic pathway gliomas (OPG) have good survival rates although their long-term quality of life can be affected by the tumor or treatment-related morbidity. This retrospective study sought to describe the clinical presentation and outcomes of children with OPG at a tertiary center in Mexico. METHODS: Consecutive patients <18 years-of-age with newly diagnosed OPG between January 2002 and December 2020 at the Hospital Civil de Guadalajara Dr...
2024: Frontiers in Oncology
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JOURNAL ARTICLE
A Gewirtz-Meydan, M Koós, L Nagy, S W Kraus, Z Demetrovics, M N Potenza, R Ballester-Arnal, D Batthyány, S Bergeron, J Billieux, J Burkauskas, G Cárdenas-López, J Carvalho, J Castro-Calvo, L Chen, G Ciocca, O Corazza, R Csako, D P Fernandez, H Fujiwara, E F Fernandez, J Fuss, R Gabrhelík, B Gjoneska, M Gola, J B Grubbs, H T Hashim, M S Islam, M Ismail, M C Jiménez-Martínez, T Jurin, O Kalina, V Klein, A Költő, S-K Lee, K Lewczuk, C-Y Lin, C Lochner, S López-Alvarado, K Lukavská, P Mayta-Tristán, D J Miller, O Orosová, G Orosz, F P Ponce, G R Quintana, G C Quintero Garzola, J Ramos-Diaz, K Rigaud, A Rousseau, M De Tubino Scanavino, M K Schulmeyer, P Sharan, M Shibata, S Shoib, V Sigre-Leirós, L Sniewski, O Spasovski, V Steibliene, D J Stein, C Strong, B C Ünsal, M-P Vaillancourt-Morel, M C Van Hout, B Bőthe
OBJECTIVES: This study aimed to examine the psychometric properties of the P4 suicide screener in a multinational sample. The primary goal was to evaluate the reliability and validity of the scale and investigate its convergent validity by analyzing its correlation with depression, anxiety, and substance use. STUDY DESIGN: The study design is a cross-sectional self-report study conducted across 42 countries. METHODS: A cross-sectional, self-report study was conducted in 42 countries, with a total of 82,243 participants included in the final data set...
February 20, 2024: Public Health
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Eder Caceres, Afshin A Divani, Clio A Rubinos, Juan Olivella-Gómez, André Emilio Viñán-Garcés, Angélica González, Alexis Alvarado-Arias, Kunal Bathia, Uzma Samadani, Luis F Reyes
Background partial pressure of carbon dioxide (PaCO2) is generally known to influence outcome in patients with traumatic brain injury (TBI) at normal altitudes. Less is known about specific relationships of PaCO2 levels and clinical outcomes at high altitudes. Methods This is a prospective single-center cohort of consecutive TBI patients admitted to a trauma center located at 2600 meter above sea level. An unfavorable outcome was defined as the Glasgow Outcome Scale-Extended (GOSE) < 4 at 6-month follow-up...
January 24, 2024: Research Square
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JOURNAL ARTICLE
Alex Bataller, Guillermo Montalban-Bravo, Alexandre Bazinet, Yesid Alvarado, Kelly Chien, Sangeetha Venugopal, Jo Ishizawa, Danielle Hammond, Mahesh Swaminathan, Koji Sasaki, Ghayas C Issa, Nicholas J Short, Lucia Masarova, Naval G Daver, Tapan M Kadia, Simona Colla, Wei Qiao, Xuelin Huang, Rashmi Kanagal-Shamanna, Stephany Hendrickson, Farhad Ravandi, Elias Jabbour, Hagop Kantarjian, Guillermo Garcia-Manero
BACKGROUND: Hypomethylating agents are approved in higher-riskmyelodysplastic syndromes. The combination of a hypomethylating agent with venetoclax is standard of care in acute myeloid leukaemia. We investigated the safety and activity of the first totally oral combination of decitabine plus cedazuridine and venetoclax in patients with higher-risk-myelodysplastic syndromes and chronic myelomonocytic leukaemia. METHODS: We did a single-centre, dose-escalation and dose-expansion, phase 1/2, clinical trial...
March 2024: Lancet Haematology
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JOURNAL ARTICLE
Identification of complicated and non-complicated appendicitis: a new alvarado-based scoring system.
Arife Polat Düzgün, Hikmet Pehlevan Özel, Eda Şahingöz, Tolga Dinç
BACKGROUND: In the presence of non-complicated appendicitis, treatment typically involves a simple appendectomy and can even be managed medically. However, in cases of complicated appendicitis, surgery becomes more difficult, and the morbidity and mortality rates increase. This study aims to develop a method for recognizing complicated acute appendicitis operatively. METHODS: This retrospective study developed a scoring system based on the Alvarado score. Several variables were scored in this new scoring system, including the Alvarado score, female gender, elevated direct bilirubin, increased appendicitis thickness, and the presence of complications as evidenced by imaging or appendicoliths...
February 2024: Turkish Journal of Trauma & Emergency Surgery: TJTES
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JOURNAL ARTICLE
Sundus A Khan, Raza Ashraf, Narmeen Hassaan, Mubashar Naseer, Muhammad Hassan Azad, Hamza Javed
BACKGROUND: Acute appendicitis (AA), a common reason for episodes of acute abdomen, is a surgical emergency. Its immediate diagnosis and management are of immense significance, as its diagnosis can become challenging at times, especially in resource-limited setups. The goal of this study was to ascertain the threshold value for the neutrophil-to-lymphocyte ratio (NLR) in diagnosing AA and to calculate the validity parameters for the NLR. METHODOLOGY: A cross-sectional study was carried out involving 108 patients who were admitted to the surgical wards of Ayub Teaching Hospital, Abbottabad with suspicion of AA and subsequently underwent open appendectomy...
December 2023: Curēus
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JOURNAL ARTICLE
Reham Abd El-Aleem, Abdelrahman A Abd Allah, Mahmoud Refaat Shehata, Gehan S Seifeldein, Sara M Hassanein
PURPOSE: This study aims to evaluate the added value of duplex Doppler examination to the routinely graded compression grayscale ultrasound (US) for patients with suspected acute appendicitis (AA) in correlation with surgical management outcomes. METHODS: The study lasted from January 2020 to March 2021. Throughout that period, patients who had suspected appendicitis were included with a visible appendix in the grayscale US. These patients were categorized clinically based on Alvarado's score...
January 24, 2024: Emergency Radiology
#18
JOURNAL ARTICLE
Gonzalo R Quintana, Fernando P Ponce, Javier I Escudero-Pastén, Juan F Santibáñez-Palma, Léna Nagy, Mónika Koós, Shane W Kraus, Zsolt Demetrovics, Marc N Potenza, Rafael Ballester-Arnal, Dominik Batthyány, Sophie Bergeron, Joël Billieux, Peer Briken, Julius Burkauskas, Georgina Cárdenas-López, Joana Carvalho, Jesús Castro-Calvo, Lijun Chen, Giacomo Ciocca, Ornella Corazza, Rita I Csako, David P Fernandez, Elaine F Fernandez, Hironobu Fujiwara, Johannes Fuss, Roman Gabrhelík, Ateret Gewirtz-Meydan, Biljana Gjoneska, Mateusz Gola, Joshua B Grubbs, Hashim T Hashim, Md Saiful Islam, Mustafa Ismail, Martha C Jiménez-Martínez, Tanja Jurin, Ondrej Kalina, Verena Klein, András Költő, Chih-Ting Lee, Sang-Kyu Lee, Karol Lewczuk, Chung-Ying Lin, Christine Lochner, Silvia López-Alvarado, Kateřina Lukavská, Percy Mayta-Tristán, Dan J Miller, Oľga Orosová, Gábor Orosz, Gabriel C Quintero Garzola, Jano Ramos-Diaz, Kévin Rigaud, Ann Rousseau, Marco De Tubino Scanavino, Marion K Schulmeyer, Pratap Sharan, Mami Shibata, Sheikh Shoib, Vera Sigre-Leirós, Luke Sniewski, Ognen Spasovski, Vesta Steibliene, Dan J Stein, Berk C Ünsal, Marie-Pier Vaillancourt-Morel, Marie Claire Van Hout, Beáta Bőthe
BACKGROUND: Depression and anxiety are among the most prevalent mental health issues experienced worldwide. However, whereas cross-cultural studies utilize psychometrically valid and reliable scales, fewer can meaningfully compare these conditions across different groups. To address this gap, the current study aimed to psychometrically assess the Brief Symptomatology Index (BSI) in 42 countries. METHODS: Using data from the International Sex Survey (N = 82,243; Mage = 32...
January 18, 2024: Journal of Affective Disorders
#19
JOURNAL ARTICLE
Ammara Saif Ullah, Reemal Mushtaq, Haseeb Mehmood Qadri, Hasan Saeed, Muhammad Sheraz, Muhammad Faraz K Nizami, Saba Waheed, Momin Ijaz, Warda Fatima, Maha Saeed
Background Histopathology of a tissue specimen plays a crucial role in formulating the final diagnosis of any disease. It confirms whether the histopathological findings are in correspondence with the clinical diagnosis and thus suggests an optimal management plan. Standard surgical practices guide that every human tissue specimen must undergo postoperative tissue analysis unless indicated otherwise. Objective To determine the significance of histopathology in determining the final diagnosis of appendectomy specimens...
December 2023: Curēus
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JOURNAL ARTICLE
Margalida Calafat, Paola Torres, Joan Tosca-Cuquerella, Rubén Sánchez-Aldehuelo, Montserrat Rivero, Marisa Iborra, María González-Vivo, Isabel Vera, Luisa de Castro, Luis Bujanda, Manuel Barreiro-de Acosta, Carlos González-Muñoza, Xavier Calvet, José Manuel Benítez, Mónica Llorente-Barrio, Gerard Surís, Fiorella Cañete, Lara Arias-García, David Monfort, Andrés Castaño-García, Francisco Javier Garcia-Alonso, José M Huguet, Ignacio Marín-Jímenez, Rufo Lorente, Albert Martín-Cardona, Juan Ángel Ferrer, Patricia Camo, Javier P Gisbert, Ramón Pajares, Fernando Gomollón, Jesús Castro-Poceiro, Jair Morales-Alvarado, Jordina Llaó, Andrés Rodríguez, Cristina Rodríguez, Pablo Pérez-Galindo, Mercè Navarro, Nuria Jiménez-García, Marta Carrillo-Palau, Isabel Blázquez-Gómez, Eva Sesé, Pedro Almela, Patricia Ramírez de la Piscina, Carlos Taxonera, Iago Rodríguez-Lago, Lidia Cabrinety, Milagros Vela, Miguel Mínguez, Francisco Mesonero, María José García, Mariam Aguas, Lucía Márquez, Marisol Silva Porto, Juan R Pineda, Koldo García-Etxebarría, Federico Bertoletti, Eduard Brunet, Míriam Mañosa, Eugeni Domènech
BACKGROUND: Infliximab seems to be the most efficacious of the three available anti-TNF agents for ulcerative colitis (UC) but little is known when it is used as the second anti-TNF. OBJECTIVES: To compare the clinical and treatment outcomes of a second subcutaneous or intravenous anti-TNF in UC patients. DESIGN: Retrospective observational study. METHODS: Patients from the ENEIDA registry treated consecutively with infliximab and a subcutaneous anti-TNF (or vice versa), naïve to other biological agents, were identified and grouped according to the administration route of the first anti-TNF into IVi (intravenous initially) or SCi (subcutaneous initially)...
2024: Therapeutic Advances in Gastroenterology
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