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https://www.readbyqxmd.com/read/28202345/circulating-human-leucine-rich-%C3%AE-2-glycoprotein-1-mrna-and-protein-levels-to-detect-acute-appendicitis-in-patients-with-acute-abdominal-pain
#1
T H Rainer, L Y Leung, Cpy Chan, Y K Leung, N M Cheng, Pbs Lai, Y S Cheung, C A Graham
BACKGROUND: Elevated levels of circulating plasma and urine leucine-rich-2-glycoprotein-1 (LRG1) protein has been found in patients with acute appendicitis (AA) and may be useful for diagnosis. This study aimed to investigate whether combined tests including circulating LRG1 mRNA levels improves the early diagnosis of AA. METHODS: Between December 2011 and October 2012, a prospective study was conducted on patients aged 18years or older presenting to the ED with acute abdominal pain (<7days of symptom onset)...
February 12, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28193849/toxoplasma-gondii-exposure-and-parkinson-s-disease-a-case-control-study
#2
Cosme Alvarado-Esquivel, Edna Madai Méndez-Hernández, José Manuel Salas-Pacheco, Luis Ángel Ruano-Calderón, Jesús Hernández-Tinoco, Oscar Arias-Carrión, Luis Francisco Sánchez-Anguiano, Francisco Xavier Castellanos-Juárez, Ada Agustina Sandoval-Carrillo, Oliver Liesenfeld, Agar Ramos-Nevárez
OBJECTIVES: To determine the association between Toxoplasma gondii infection and Parkinson's disease and to investigate whether T. gondii seropositivity is associated with the general characteristics of patients with Parkinson's disease. DESIGN: Case-control study. SETTING: Cases and controls were enrolled in Durango City, Mexico. PARTICIPANTS: 65 patients with Parkinson's disease and 195 age- and gender-matched control subjects without Parkinson's disease...
February 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28161396/the-method-used-to-set-the-pass-mark-in-an-objective-structured-clinical-examination-defines-the-performance-of-candidates-for-certification-as-rheumatologists
#3
Virginia Pascual-Ramos, Gabriel Medrano-Ramírez, Eunice Solís-Vallejo, Ana Guilaisne Bernard-Medina, Diana Elsa Flores-Alvarado, Margarita Portela-Hernández, María Del Rocío Maldonado-Velázquez, Luis Javier Jara-Quezada, Luis Manuel Amezcua-Guerra, Judith López-Zepeda, Miguel Ángel Saavedra, César Alejandro Arce-Salinas
BACKGROUND: The Mexican Accreditation Council for Rheumatology certifies trainees (TR) on an annual basis using both a multiple-choice question (MCQ) test and an objective structured clinical examination (OSCE). For 2013 and 2014, the OSCE pass mark (PM) was set by criterion referencing as ≥6 (CPM), whereas overall rating of borderline performance method (BPM) was added for 2015 and 2016 accreditations. We compared OSCE TR performance according to CPM and BPM, and examined whether correlations between MCQ and OSCE were affected by PM...
February 1, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28069112/-immunohistochemical-assessment-of-her2-expression-in-gastric-cancer-a-clinicopathologic-study-of-93-cases
#4
Isabel Alvarado-Cabrero, Sara Gil-Hernández, Ana Ruelas-Perea, Diego Villaverde-Rodríguez, José Roberto Montes-Ochoa, Rafael Medrano-Guzmán
BACKGROUND: Gastric cancer in Mexico is ranked third in both males and females. Most patients present clinically with advanced disease and treatment options are sparse. HER2 overexpression in gastric cancer is related to poor outcome. Immunohistochemical testing for HER2 is becoming the standard of care for guiding adjuvant treatment of gastric cancer with trastuzumab. OBJECTIVES: To determine the frequency of HER2 overexpression in patients with gastric cancer in the Hospital de Oncología del Centro Médico Nacional, Siglo XXI and its association with other histopathological findings...
January 6, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28053898/aromatherapy-with-two-essential-oils-from-satureja-genre-and-mindfulness-meditation-to-reduce-anxiety-in-humans
#5
Marilú Roxana Soto-Vásquez, Paúl Alan Arkin Alvarado-García
The goal of this study was to verify whether association of aromatherapy with essential oils of Satureja brevicalyx or Satureja boliviana and mindfulness meditation can reduce anxiety levels in humans. A randomized experimental trial was carried out with 108 participants who were divided into 6 groups, comprising a waiting list control group and five experimental groups. Aromatherapy was carried out by inhalation of essential oils while mindfulness intervention program was focused on "flow meditation". The anxiety index was evaluated by State-Trait Anxiety Inventory (STAI)...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28043980/fear-of-falling-and-its-association-with-life-space-mobility-of-older-adults-a-cross-sectional-analysis-using-data-from-five-international-sites
#6
Mohammad Auais, Beatriz Alvarado, Ricardo Guerra, Carmen Curcio, Ellen E Freeman, Alban Ylli, Jack Guralnik, Nandini Deshpande
BACKGROUND: fear of falling (FOF) is a major health concern among community-dwelling older adults that could restrict mobility. OBJECTIVE: to examine the association of FOF with life-space mobility (i.e. the spatial area a person moves through in daily life) of community-dwelling older adults from five diverse sites. METHODS: in total, 1,841 older adults (65-74 years) were recruited from Kingston, Canada; Saint-Hyacinthe, Canada; Tirana, Albania; Manizales, Colombia and Natal, Brazil...
January 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28042240/prevalence-of-irritable-bowel-syndrome-and-health-related-quality-of-life-in-adults-aged-18-to-30-years-in-a-colombian-university-an-electronic-survey
#7
Martín Cañón, Alvaro J Ruiz, Martín Rondón, Jaime Alvarado
BACKGROUND: We estimated the prevalence of irritable bowel syndrome (IBS) and its impact on patient-reported health-related quality of life (HR-QOL) in a university-based population aged between 18 and 30 years in Bogotá, Colombia. METHODS: The study had a cross-sectional design. Students, faculty, and staff aged 18-30 years of the Pontificia Universidad Javeriana, Bogotá, Colombia were randomly selected and invited to complete an electronic survey containing the Rome III IBS diagnostic questionnaire and an IBS-specific HR-QOL instrument (IBS-QOL)...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/27981378/the-ripasa-score-is-sensitive-and-specific-for-the-diagnosis-of-acute-appendicitis-in-a-western-population
#8
Muhammad Usman Malik, Tara M Connelly, Faisal Awan, Frederik Pretorius, Constantino Fiuza-Castineira, Osama El Faedy, Paul Balfe
AIM: The definitive diagnosis of acute appendicitis (AA) requires histopathological examination. Various clinical diagnostic scoring systems attempt to reduce negative appendectomy rates. The most commonly used in Western Europe and the USA is the Alvarado score. The Raja Isteri Pengiran Anak Saleha appendicitis (RIPASA) score achieves better sensitivity and specificity in Asian and Middle Eastern populations. We aimed to determine the diagnostic accuracy of the RIPASA score in Irish patients with AA...
December 15, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27941962/microalbuminuria-and-its-association-with-subclinical-atherosclerosis-in-the-mexican-mestizo-population-the-gea-study
#9
Aida Medina-Urrutia, Juan Gabriel Juárez-Rojas, Rosalinda Posadas-Sánchez, Esteban Jorge-Galarza, Guillermo Cardoso-Saldaña, Gilberto Vargas-Alarcón, Rocío Martínez-Alvarado, Carlos Posadas-Romero
BACKGROUND: Microalbuminuria is an early marker of atherosclerosis. Ethnic differences for both conditions have been reported. We studied microalbuminuria prevalence and its association with coronary artery calcification as an early atherosclerosis marker in a Mexican-Mestizo population free of diabetes and hypertension (healthy), as well as in hypertensive and diabetic subjects. METHODS: In 1,472 adults (53.3 ± 9.4 years old, 50.3% women), anthropometric measurements, fasting blood glucose, and lipid profile were determined...
September 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27896652/the-long-term-efficacy-and-safety-of-pyloroplasty-combined-with-gastric-electrical-stimulation-therapy-in-gastroparesis
#10
Brian R Davis, Irene Sarosiek, Mohammad Bashashati, Ben Alvarado, Richard W McCallum
INTRODUCTION: Gastroparesis is delayed gastric emptying without mechanical obstruction. Symptomatic improvement can be 50-60% with gastric electrical stimulation. To address delayed gastric emptying, pyloroplasty was added. This study examines the long-term efficacy and safety of simultaneous gastric electrical stimulator implantation and pyloroplasty. METHODS: In this prospective single-arm trial conducted from 2012 to 2015, 27 [23 females; mean age 43 (22-63)] gastroparesis patients who underwent simultaneous gastric electrical stimulator implantation with Heineke-Mikulicz pyloroplasty were studied...
November 28, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27843179/the-alvarado-score-versus-computed-tomography-in-the-diagnosis-of-acute-appendicitis-a-prospective-study
#11
Ashraf F Al-Faouri, Khaled Y Ajarma, Abdulhamid M Al-Abbadi, Abdullah H Al-Omari, Tariq S Almunaizel, Alaa A Alzu'bi, Ra'ed Y Al-Jarrah, Omar Y Abo-Zaiton
BACKGROUND: To assess and compare performance of the Alvarado score and computed tomography scan in the diagnosis of acute appendicitis at King Hussein Medical Center. METHODS: A total of 320 patients with suspected acute appendicitis were included in this study over a period of 2 years. The Alvarado score was calculated for all of these patients and 112 CT scans were requested selectively by surgeons caring for the patients. The histopathology diagnosis was used as the gold standard against which diagnostic performance of Alvarado score and CT scan were compared...
October 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27806437/dilemma-of-mucosal-appendicitis-a-clinico-pathological-entity-a-retrospective-cohort-study
#12
Ryo Mizumoto, Adam T Cristaudo, Nai Kid Lai, Gamini Premaratne, Rasika Hendahewa
BACKGROUND: The presence of mucosal inflammation within appendicectomy specimens is poorly described in the literature, and there is debate regarding the clinical significance of this histological finding. The aim of this study is to correlate clinical and radiological data with histologically confirmed acute mucosal appendicitis (MA). METHODS: A retrospective cohort study was performed to identify all patients who underwent appendicectomy over 5 years at Caboolture Hospital...
November 2, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27803737/impact-of-ornithine-phenylacetate-ocr-002-in-lowering-plasma-ammonia-after-upper-gastrointestinal-bleeding-in-cirrhotic-patients
#13
Meritxell Ventura-Cots, Mar Concepción, José Antonio Arranz, Macarena Simón-Talero, Maria Torrens, Albert Blanco-Grau, Inma Fuentes, Pilar Suñé, Edilmar Alvarado-Tapias, Cristina Gely, Eva Roman, Beatriz Mínguez, German Soriano, Joan Genescà, Juan Córdoba
BACKGROUND: Ornithine phenylacetate (OP) has been proven effective in lowering ammonia plasma levels in animals, and to be well tolerated in cirrhotic patients. A trial to assess OP efficacy in lowering plasma ammonia levels versus placebo in cirrhotic patients after an upper gastrointestinal bleeding was performed. The primary outcome was a decrease in venous plasma ammonia at 24 hours. METHODS: A total of 38 consecutive cirrhotic patients were enrolled within 24 hours of an upper gastrointestinal bleed...
November 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/27733949/relationship-between-temperament-and-character-traits-mood-and-medications-in-bipolar-i-disorder
#14
Sergio B Chavez, Luis A Alvarado, Robert Gonzalez
INTRODUCTION: Bipolar I disorder is an illness causing mood shifts that can result in personality and character trait alterations. The relationship between mood and personality and character traits in bipolar I disorder is unclear at this time. METHODS: We conducted a study from February 2009 to March 2010 that included 42 subjects with bipolar I disorder, which was confirmed using the Structured Clinical Interview for DSM-IV Axis I Disorders. Mood was assessed via the Young Mania Rating Scale (YMRS) and the 30-item Clinician-rated Inventory of Depressive Symptomatology (IDS-C)...
2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27729567/allowing-new-opportunities-in-advanced-laparoscopy-training-using-a-full-high-definition-training-box
#15
Pablo Achurra, Antonia Lagos, Ruben Avila, Rodrigo Tejos, Erwin Buckel, Juan Alvarado, Camilo Boza, Nicolas Jarufe, Julian Varas
Introduction Simulated laparoscopy training is limited by its low-quality image. A high-definition (HD) laparoscopic training box was developed under the present necessity of simulating advanced surgery. Objective To describe and test a new HD laparoscopic training box for advanced simulation training. Methods We describe the features and image quality of the new training box. The simulator was tested and then evaluated by a group of 76 expert surgeons using a 4-item questionnaire. To assess the effectiveness of training using this simulation box, 15 general surgery residents were trained to perform a laparoscopic jejuno-jejunostomy in a validated simulation program...
October 10, 2016: Surgical Innovation
https://www.readbyqxmd.com/read/27723842/clinical-importance-of-the-heel-drop-test-and-a-new-clinical-score-for-adult-appendicitis
#16
Shin Ahn, Hyeji Lee, Wookjin Choi, Ryeok Ahn, Jung-Suk Hong, Chang Hwan Sohn, Dong Woo Seo, Yoon-Seon Lee, Kyung Soo Lim, Won Young Kim
OBJECTIVE: We tried to evaluate the accuracy of the heel drop test in patients with suspected appendicitis and tried to develop a new clinical score, which incorporates the heel drop test and other parameters, for the diagnosis of this condition. METHODS: We performed a prospective observational study on adult patients with suspected appendicitis at two academic urban emergency departments between January and August 2015. The predictive characteristics of each parameter, along with heel drop test results were calculated...
2016: PloS One
https://www.readbyqxmd.com/read/27625212/incidence-of-normal-white-cell-count-and-c-reactive-protein-in-adults-with-acute-appendicitis
#17
Nalin H Dayawansa, Julian D S Segan, Henry H I Yao, Hon I Chong, Paul J Sitzler
BACKGROUND: Normal C-reactive protein (CRP) and white cell count (WCC) are often used to exclude a diagnosis of acute appendicitis in the Emergency Department (ED). Retrospective review of 281 adult patients with acute appendicitis was performed to study the incidence of normal CRP and WCC on admission and examine any possible predisposing factors. METHOD: Retrospective analysis of patient clinical records yielded CRP, WCC, operative diagnosis, time of symptom onset, imaging results and history and examination features...
September 14, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27613754/diagnostic-accuracy-of-the-appy1-test-in-patients-aged-2-20-years-with-suspected-acute-appendicitis-presenting-to-emergency-departments
#18
Juan González Del Castillo, Francisco Javier Ayuso, Victoria Trenchs, Mikel Martinez Ortiz de Zarate, Carmen Navarro, Kinda Altali, Cristina Fernandez, David Huckins, Francisco Javier Martín-Sánchez
OBJECTIVE: Evaluate the diagnostic accuracy of the APPY1 Test alone and in combination with the Alvarado score (AS) to rule out acute appendicitis (AA) in patients presenting to EDs with abdominal pain suspicious for AA. METHODOLOGY: Observational study in a prospective consecutive cohort including all patients from 2 to 20 years with abdominal pain suggestive of AA in four EDs. The APPY1 Test was performed and AS was calculated to determine risk stratification for each patient...
December 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27577252/test-characteristics-of-common-appendicitis-scores-with-and-without-laboratory-investigations-a-prospective-observational-study
#19
Ijab Khanafer, Dori-Ann Martin, Tatum P Mitra, Robin Eccles, Mary E Brindle, Alberto Nettel-Aguirre, Graham C Thompson
BACKGROUND: Despite the poor independent test characteristics of the white blood cell count (WBC) and neutrophil count (NC) in identifying appendicitis, common clinical decision supports including the Pediatric Appendicitis Score (PAS) and Alvarado Score (AS), require the WBC and NC values. Moreover, blood tests cause discomfort/pain to children and require time for processing results. Scores based on clinical information alone may be of benefit in the pediatric population. The objective of our study was to determine the test characteristics of the PAS and the AS with and without laboratory investigations (mPAS, mAS respectively) as well as the Lintula Score...
August 30, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27566595/results-of-colon-cancer-surgery-in-patients-over-75-years-old
#20
Lucinda Pérez Domínguez, Nieves Cáceres Alvarado, Ángeles Toscano Novella, José Enrique Casal Núñez
BACKGROUND: Colon cancer is the second most frequent cause of death in both genders. Survival has increased since 1980, although this increase has been lower in patients ≥75 years old. We analyzed the results of surgical treatment for this pathology in this group of patients. METHODS: This retrospective, observational and descriptive study analyzed data relating to 315 patients undergoing colon cancer surgery between January 2010 and December 2011. Surgical results (surgical procedure, mean postoperative stay, isolated lymph nodes, postoperative morbidity and mortality) were compared between patients who were <75 and ≥75 years old...
August 26, 2016: ANZ Journal of Surgery
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