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https://www.readbyqxmd.com/read/29146455/successful-nonoperative-management-of-uncomplicated-appendicitis-predictors-and-outcomes
#1
Tyler J Loftus, Scott C Brakenridge, Chasen A Croft, R Stephen Smith, Philip A Efron, Frederick A Moore, Alicia M Mohr, Janeen R Jordan
BACKGROUND: Our objective was to identify predictors of successful nonoperative management (NOM) of uncomplicated appendicitis. We hypothesized that the absence of diabetes, absence of an appendicolith, short duration of symptoms, absence of systemic inflammation, and low modified Alvarado score would predict successful NOM. METHODS: We performed a retrospective cohort analysis of 81 consecutive patients who underwent NOM of uncomplicated appendicitis. Successful NOM was defined as resolution of appendicitis with antibiotics alone and no recurrent appendicitis within 180 days...
November 13, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29136682/exploring-the-cancer-caregiver-s-journey-through-web-based-meaning-centered-psychotherapy
#2
A J Applebaum, K L Buda, E Schofield, M Farberov, N D Teitelbaum, K Evans, R Cowens-Alvarado, R S Cannady
PURPOSE: Psychosocial interventions are historically underutilized by cancer caregivers, but support programs delivered flexibly over the Internet address multiple barriers to care. We adapted Meaning-Centered Psychotherapy for Cancer Caregivers, an in-person psychotherapeutic intervention intended to augment caregivers' sense of meaning and purpose and ameliorate burden, for delivery in a self-administered web-based program, the Care for the Cancer Caregiver (CCC) Workshop. The present study evaluated the feasibility, acceptability, and preliminary effects of this program...
November 14, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29136645/a-4-mirna-signature-to-predict-survival-in-glioblastomas
#3
Simon K Hermansen, Mia D Sørensen, Anker Hansen, Steen Knudsen, Alvaro G Alvarado, Justin D Lathia, Bjarne W Kristensen
Glioblastomas are among the most lethal cancers; however, recent advances in survival have increased the need for better prognostic markers. microRNAs (miRNAs) hold great prognostic potential being deregulated in glioblastomas and highly stable in stored tissue specimens. Moreover, miRNAs control multiple genes representing an additional level of gene regulation possibly more prognostically powerful than a single gene. The aim of the study was to identify a novel miRNA signature with the ability to separate patients into prognostic subgroups...
2017: PloS One
https://www.readbyqxmd.com/read/29128890/the-alvarado-score-is-accurate-in-pregnancy-a-retrospective-case-control-study
#4
F Tatli, Y Yucel, O Gozeneli, A Dirican, A Uzunkoy, H C Yalçın, A Ozgonul, O Bardakci, H Uyanikoglu, A İncebiyik
BACKGROUND: Acute appendicitis is the most frequent abdominal condition that requires non-obstetric surgical intervention during pregnancy. This study aims to scan pregnant patients operated on for acute appendicitis to evaluate the efficiency of using the Alvarado Score (AS) for diagnosis. METHODS: Our study included 48 pregnant patients who were pre-diagnosed with acute appendicitis and operated on at our department of general surgery from January 2010 to July 2016 and whose files were accessed...
November 11, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29123606/evaluation-of-a-point-of-care-ultrasound-curriculum-for-indonesian-physicians-taught-by-first-year-medical-students
#5
Jonathan B Lee, Christina Tse, Thomas Keown, Michael Louthan, Christopher Gabriel, Alexander Anshus, Bima Hasjim, Katrina Lee, Esther Kim, Luke Yu, Allen Yu, Shadi Lahham, Steven Bunch, Maili Alvarado, Abdulatif Gari, John C Fox
BACKGROUND: The purpose of this study was to assess the short-term efficacy of a 4-week ultrasound curriculum taught by American first-year medical students to general practitioners working in public health care clinics, or puskesmas, in Bandung, Indonesia. METHODS: We performed a prospective, observational study of Indonesian health care practitioners from public clinics in Bandung, Indonesia. These practitioners were enrolled in a 4-week ultrasound training course taught by first-year American medical students...
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29123605/evaluation-of-modified-alvarado-scoring-system-and-ripasa-scoring-system-as-diagnostic-tools-of-acute-appendicitis
#6
Abdullah Shuaib, Ali Shuaib, Zainab Fakhra, Bader Marafi, Khalid Alsharaf, Abdullah Behbehani
BACKGROUND: Acute appendicitis is the most common surgical condition presented in emergency departments worldwide. Clinical scoring systems, such as the Alvarado and modified Alvarado scoring systems, were developed with the goal of reducing the negative appendectomy rate to 5%-10%. The Raja Isteri Pengiran Anak Saleha Appendicitis (RIPASA) scoring system was established in 2008 specifically for Asian populations. The aim of this study was to compare the modified Alvarado with the RIPASA scoring system in Kuwait population...
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29092844/adolescent-childbirth-is-associated-with-greater-framingham-risk-scores-for-cardiovascular-disease-among-participants-of-the-imias-international-mobility-in-aging-study
#7
Nicole T A Rosendaal, Beatriz Alvarado, Yan Yan Wu, Maria P Velez, Saionara M Aires da Câmara, Catherine M Pirkle
BACKGROUND: Previous studies observe associations between lifetime parity and cardiovascular disease, but relatively fewer investigate age at first childbirth (AFB). Herein, we examine the association of AFB with a summary cardiovascular risk measure (Framingham Risk Score [FRS]). METHODS AND RESULTS: As part of the IMIAS (International Mobility in Aging Study), data were collected in 2012 among 1047 women, aged 65 to 74 years, from Canada, Albania, Colombia, and Brazil...
November 1, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29055962/can-clinical-scoring-systems-improve-the-diagnostic-accuracy-in-patients-with-suspected-adult-appendicitis-and-equivocal-preoperative-computed-tomography-findings
#8
Min Seok Chae, Chong Kun Hong, Young Rock Ha, Minjung Kathy Chae, Young Sik Kim, Tae Yong Shin, Jung Hwan Ahn
Objective: Adult appendicitis (AA) with equivocal computed tomography (CT) findings remains a diagnostic challenge for physicians. Herein we evaluated the diagnostic performance of several clinical scoring systems in adult patients with suspected appendicitis and equivocal CT findings. Methods: We retrospectively evaluated 189 adult patients with equivocal CT findings. Alvarado, Eskelinen, appendicitis inflammatory response, Raja Isteri Pengiran Anak Saleha Appendicitis (RIPASA), and adult appendicitis score (AAS) scores were evaluated, receiver operating characteristic analysis was conducted, and the optimal, low, and high cut-off values were determined for patient classification into three groups: low, intermediate, or high...
October 20, 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/28992348/location-of-glomerular-immune-deposits-not-codeposition-of-immunoglobulin-g-influences-definitive-renal-outcomes-in-immunoglobulin-a-nephropathy
#9
Anthony S Alvarado, Nicole K Andeen, Sergey Brodsky, Alice Hinton, Tibor Nadasdy, Charles E Alpers, Christopher Blosser, Behzad Najafian, Brad H Rovin
Background: It has been suggested that the prognosis of immunoglobulin (IgA) nephropathy (IgAN) is adversely affected if there is codeposition of IgG in the glomeruli or if immune deposits are present in the glomerular capillary walls. We sought to understand how these variables affect clinical outcome. Methods: A total of 80 IgAN biopsies were retrospectively divided into groups: (i) IgA without IgG deposition versus IgA + IgG and (ii) immune deposits restricted to the mesangium versus mesangium and peripheral capillary walls (PCWs)...
August 16, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28988188/enterobius-vermicularis-pinworm-infestation-in-a-child-presenting-with-symptoms-of-acute-appendicitis-a-wriggly-tale
#10
Louise Dunphy, Zoe Clark, Mazhar H Raja
Acute appendicitis is the most common surgical emergency worldwide. However, it can still present a challenging diagnosis especially in the young, elderly and those individuals of reproductive age, thus encompassing a wide spectrum of varied clinical presentations. Parasitic infections of the appendix are a rare cause of acute appendicitis. However, they must be considered in children presenting with abdominal pain. We report a case of Enterobius vermicularis infestation mimicking the features of acute appendicitis in a 10-year-old girl...
October 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28944334/evaluation-of-the-alvarado-scoring-system-in-the-management-of-acute-appendicitis
#11
Zeki Özsoy, Erdinç Yenidoğan
OBJECTIVE: In this study, we aimed to show the effectiveness of Alvarado score and its components to predict the correct diagnosis of acute appendicitis and to find an optimum cut-off value for Alvarado score. MATERIAL AND METHODS: The patients who underwent surgical operation between January 2011 and January 2012 with the suspicion of acute appendicitis were included in the study. Their demographic and clinical features and histopathological results were retrieved from the medical records...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28888674/geographical-variations-in-clinical-presentation-and-outcomes-of-decompressive-surgery-in-patients-with-symptomatic-degenerative-cervical-myelopathy-analysis-of-a-prospective-international-multicenter-cohort-study-of-757-patients
#12
Michael G Fehlings, Branko Kopjar, Ahmed Ibrahim, Lindsay A Tetreault, Paul M Arnold, Helton Defino, Shashank Sharad Kale, S Tim Yoon, Giuseppe M Barbagallo, Ronald H M Bartels, Qiang Zhou, Alexander R Vaccaro, Mehmet Zileli, Gamaliel Tan, Yasutsugu Yukawa, Darrel S Brodke, Christopher I Shaffrey, Osmar Santos de Moraes, Eric J Woodard, Massimo Scerrati, Masato Tanaka, Tomoaki Toyone, Rick C Sasso, Michael E Janssen, Ziya L Gokaslan, Manuel Alvarado, Ciaran Bolger, Christopher M Bono, Mark B Dekutoski
BACKGROUND CONTEXT: Degenerative cervical myelopathy (DCM) is a progressive degenerative spine disease and the most common cause of spinal cord impairment in adults worldwide. There is a paucity of studies reporting on regional variations in demographics, clinical presentation, disease causation and surgical effectiveness. PURPOSE: To evaluate differences in demographics, causative pathology, management strategies, surgical outcomes, length of hospital stay and complications across four geographic regions...
September 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28888024/airflow-and-symptom-outcomes-between-allergic-and-non-allergic-rhinitis-patients-from-turbinoplasty
#13
K Parthasarathi, J M Christensen, R Alvarado, H P Barham, R Sacks, R J Harvey
BACKGROUND: Inferior turbinate procedures are applied to relieve medically refractory nasal obstruction. However, the nature of congestion differs between allergic(AR) and non-allergic rhinitis(NAR). This study compares surgical outcomes between AR and NAR patients. METHODOLOGY: A case-control study of patients undergoing turbinate with or without septoplasty surgery for nasal obstruction was performed. Patient reported outcomes were: nasal obstruction, global nasal function(GNF), and sino-nasal outcome test(SNOT-22) with rhinitis, facial symptom, sleep and psychological sub-scores...
September 9, 2017: Rhinology
https://www.readbyqxmd.com/read/28887605/the-possible-protective-effect-of-marital-status-in-quality-of-life-among-elders-in-a-u-s-mexico-border-city
#14
Marisela Gutiérrez-Vega, Oscar Armando Esparza-Del Villar, Irene Concepción Carrillo-Saucedo, Priscila Montañez-Alvarado
The purpose of this study was to determine how marital status may have an impact on quality of life in a group of older adults living in a U.S.-Mexico border city. Two-hundred and seventy-six older adults completed the Spanish version of the World Health Organization Quality of Life Assessment, composed of four domains: physical health, psychological health, social relationships, and environment. Participants answered a measure of sociodemographic variables. In the psychological health component of quality of life, single and married older adults had the highest scores as compared to widowed and divorced...
September 8, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28876141/utility-of-soluble-triggering-receptor-expressed-on-myeloid-cells-1-strem-1-as-biomarker-to-predict-therapeutic-response-to-methotrexate-in-rheumatoid-arthritis
#15
Jorge I Gamez-Nava, David Bonilla-Lara, Juan M Ponce-Guarneros, J Alejandro Zuñiga-Mora, Edsaul E Perez-Guerrero, Jessica D Murillo-Vazquez, Itzel N Becerra-Alvarado, N Alejandra Rodriguez-Jimenez, A Miriam Saldaña-Cruz, M Luisa Vazquez-Villegas, Erika Y Vera-Navarrete, Fabiola Gonzalez-Ponce, Laura Gonzalez-Lopez
The objective of this study was to investigate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in predicting short-term therapeutic response to methotrexate (MTX) in rheumatoid arthritis (RA). Patients with active RA, with Disease Activity Score-28 joints (DAS-28) >3.2, starting oral MTX, were included. We measured at baseline, 3 and 6 mo: DAS-28, Health Assessment Questionnaire-Disability Index (HAQ-DI), patient's perception of disease severity, morning stiffness and pain, as well as modifications in sTREM-1 levels...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28846723/habitat-quality-affects-the-incidence-of-morphological-abnormalities-in-the-endangered-salamander-ambystoma-ordinarium
#16
Carlos Soto-Rojas, Ireri Suazo-Ortuño, José Arturo Montoya Laos, Javier Alvarado-Díaz
Identification of early warning signals previous to the occurrence of population decline or extinction is a major challenge for the conservation of animal species. Prevalence of morphological abnormalities in a population can be one of these signals. We registered morphological abnormalities in the salamander Ambystoma ordinarium. We also evaluated the relation between habitat quality and the prevalence of abnormalities in this species. We used scores from rapid bioassessment protocols (RBPs) to assess the habitat quality of streams inhabited by A...
2017: PloS One
https://www.readbyqxmd.com/read/28833159/best-practices-for-multidisciplinary-integration-of-a-dcis-genomic-assay-into-clinical-practice
#17
Michael Alvarado, Anthony Lucci, Jennifer Manders
Most newly diagnosed ductal carcinoma in situ (DCIS) is treated with breast-conserving surgery (BCS) ± radiation therapy (RT). A key challenge is deciding whether or not to include RT with BCS. This decision is often determined by the degree of risk associated with disease recurrence. However, methods for risk assessment have not kept pace with diagnostic advances. The DCIS Score is an independent predictor and quantifier of individualized recurrence risk in patients with DCIS. Although the test is the only available genomic classifier for DCIS, the degree of adoption is varied, and it has not yet been fully accepted as standard practice...
August 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28774880/randomized-phase-2-study-of-low-dose-decitabine-vs-low-dose-azacitidine-in-lower-risk-mds-and-mds-mpn
#18
RANDOMIZED CONTROLLED TRIAL
Elias Jabbour, Nicholas J Short, Guillermo Montalban-Bravo, Xuelin Huang, Carlos Bueso-Ramos, Wei Qiao, Hui Yang, Chong Zhao, Tapan Kadia, Gautam Borthakur, Naveen Pemmaraju, Koji Sasaki, Zeev Estrov, Jorge Cortes, Farhad Ravandi, Yesid Alvarado, Rami Komrokji, Mikkael A Sekeres, David P Steensma, Amy DeZern, Gail Roboz, Hagop Kantarjian, Guillermo Garcia-Manero
Hypomethylating agents (HMAs) improve survival in patients with higher-risk myelodysplastic syndromes (MDS) but are less well-studied in lower-risk disease. We compared the safety and efficacy of low-dose decitabine vs low-dose azacitidine in this group of patients. Adults with low- or intermediate 1-risk MDS or MDS/myeloproliferative neoplasm (MPN), including chronic myelomonocytic leukemia, according to the International Prognostic Scoring System, were randomly assigned using a Bayesian adaptive design to receive either azacitidine 75 mg/m(2) intravenously/subcutaneously daily or decitabine 20 mg/m(2) intravenously daily for 3 consecutive days on a 28-day cycle...
September 28, 2017: Blood
https://www.readbyqxmd.com/read/28755908/communication-skills-in-candidates-for-accreditation-in-rheumatology-are-correlated-with-candidate-s-performance-in-the-objective-structured-clinical-examination
#19
Virginia Pascual-Ramos, Diana Elsa Flores-Alvarado, Margarita Portela-Hernández, María Del Rocío Maldonado-Velázquez, Luis Manuel Amezcua-Guerra, Judith López-Zepeda, Everardo Álvarez, Nadina Rubio, Olga Vera Lastra, Miguel Ángel Saavedra, César Alejandro Arce-Salinas
BACKGROUND: The Mexican Accreditation Council for Rheumatology annually certifies trainees in Rheumatology using a multiple-choice test and an objective structured clinical examination (OSCE). Since 2015, candidate's communication skills (CS) have been rated by both patients and by physician examiners and correlated with results on the OSCE. This study compared the CS from candidates to annual accreditation in Rheumatology as rated by patients and by physician examiners, and assessed whether these correlated with candidate's performance in the OSCE...
July 26, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28738954/the-utility-of-the-alvarado-score-in-the-diagnosis-of-acute-appendicitis-in-the-elderly
#20
Anastasiya Shchatsko, Rebecca Brown, Trista Reid, Sasha Adams, Amy Alger, Anthony Charles
Clinical scores determining the likelihood of acute appendicitis (AA), including the Alvarado score, were devised using a younger population, and their efficacy in predicting AA in elderly patients is not well documented. This study's purpose is to evaluate the utility of Alvarado scores in this population. A retrospective chart review of patients >65 years old presenting with pathologically diagnosed AA from 2000 to 2010 was performed. Ninety-six patients met inclusion criteria. The average age was 73.7 ± 1...
July 1, 2017: American Surgeon
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