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https://www.readbyqxmd.com/read/28759518/assessment-of-organ-dosimetry-for-planning-repeat-treatments-of-high-dose-131i-mibg-therapy-123i-mibg-versus-posttherapy-131i-mibg-imaging
#1
Neeta Pandit-Taskar, Pat Zanzonico, Patrick Hilden, Irina Ostrovnaya, Jorge A Carrasquillo, Shakeel Modak
PURPOSE: To evaluate detailed organ-based radiation-absorbed dose for planning double high-dose treatment with I-MIBG. METHODS: In a prospective study, 33 patients with high-risk refractory or recurrent neuroblastoma were treated with high-dose I-MIBG. Organ dosimetry was estimated from the first I-MIBG posttherapy imaging and from subsequent I-MIBG imaging prior to the planned second administration. Three serial whole-body scans were performed per patient 2 to 6 days after I-MIBG therapy (666 MBq/kg or 18 mCi/kg) and approximately 0...
July 29, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28751451/131i-labeled-anti-her2-camelid-sdab-as-a-theranostic-tool-in-cancer-treatment
#2
Matthias D'Huyvetter, Jens De Vos, Catarina Xavier, Marek Pruszynski, Yann G J Sterckx, Sam Massa, Geert Raes, Vicky Caveliers, Michael Zalutsky, Tony Lahoutte, Nick Devoogdt
<p>Camelid single-domain antibody-fragments (sdAbs) have beneficial pharmacokinetic properties, and those targeted to HER2 can be used for imaging of HER2-overexpressing cancer. Labeled with a therapeutic radionuclide, they may be used for HER2-targeted therapy. Here we describe the generation of a (131)I-labeled sdAb as a theranostic drug to treat HER2-overexpressing cancer.</p> <br />Experimental Design: <p>Anti-HER2 sdAb 2Rs15d was labeled with (131)I using [(131)I]SGMIB and evaluated in vitro Biodistribution was evaluated in two HER2(+) murine xenograft models by micro-SPECT/CT imaging and at necropsy, and under challenge with trastuzumab and pertuzumab...
July 27, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28719405/clinical-outcomes-1-year-after-empiric-131i-therapy-for-hyperthyroid-disorders-real-life-experience-and-predictive-factors-of-functional-response
#3
Lavinia Vija Racaru, Charlotte Fontan, Mathilde Bauriaud-Mallet, Séverine Brillouet, Olivier Caselles, Slimane Zerdoud, Delphine Bastié, Delphine Vallot, Philippe Caron, Manuel Bardiès, Frederic Courbon
: Radioiodine is a therapeutic option in Europe for Graves' disease (GD) and toxic multinodular goiter (MNG). PURPOSE: To compare empiric and calculated I activities using 2013 EANM recommendations. To look for predictive factors of therapeutic response to an empiric activity of I. To assess clinical situations favoring calculated treatment modalities. PATIENTS AND METHODS: Prospective monocentric study of clinical outcomes at 1 year follow-up in 86 patients with GD and MNG who received empiric I therapeutic activities (348-939 MBq)...
July 17, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28707573/synthesis-radiosynthesis-and-metabolism-of-131i-y-c-cgrraggsc
#4
Jilai Xie, Donghui Pan, Mudan Lu, Xuan Chen, Yu Chen, Ting Zhang, Yan Xie, Huan Zhou, Lu Liu, Min Yang, Jiajun Wang, Daozhen Chen
BACKGROUND: The formation of the complex interleukin-11(IL-11) and IL-11 receptor (IL-11R) is closely related with tumor progression. Binding of IL-11 to the IL-11 receptor α-chain (IL-11Rα) has been suggested as a target for human cancer. The cyclic peptide c(CGRRAGGSC) is a mimic of IL-11. OBJECTIVE: To explore 131I-Y-c(CGRRAGGSC) synthesis and radiosynthesis, and metabolism in SKOV3 tumor-bearing mice. METHOD: In this study, 131I labeled c(CGRRAGGSC) was designed and characterized...
July 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28662033/a-phase-i-study-of-pazopanib-in-combination-with-escalating-doses-of-131i-in-patients-with-well-differentiated-thyroid-carcinoma-borderline-refractory-to-radioiodine
#5
Laura Q Chow, Rafael Santana-Davila, Austin Pantel, Mara Roth, Leslie N Anderson, Alan Failor, Robert Doot, David Mankoff
OBJECTIVE: This trial was conducted to evaluate the ability of pazopanib to overcome therapeutic 131I resistance. MATERIALS, METHODS AND PATIENTS: This phase 1 trial assesses the combination of pazopanib and escalating doses of radioiodine (131I) in patients with recurrent or metastatic thyroid cancer that are borderline or relatively iodine refractory. Radioiodine uptake scans were assessed post therapy and compared to historical pre-treatment scans. Patients underwent FDG PET/CT before and after the initial pazopanib treatment to identify the impact of pazopanib on the cancer prior to 131I therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28605448/efficacy-of-peptide-receptor-radionuclide-therapy-prrt-for-functional-metastatic-paraganglioma-and-phaeochromocytoma
#6
Grace Kong, Simona Grozinsky-Glasberg, Michael S Hofman, Jason Callahan, Amichay Meirovitz, Ofra Maimon, David A Pattison, David J Gross, Rodney J Hicks
Purpose: Treatment options for unresectable Paraganglioma (PGL)/Phaeochromocytoma (PCC), especially with uncontrolled secondary hypertension (HTN) are limited. Preliminary studies with PRRT suggest efficacy but data on HTN control and survival are lacking. We assessed PRRT outcomes in such patients from 2 referral centres. Methods: 20 consecutive patients (M:F=13:7; 21-77y.o.) with high somatostatin receptor (SSTR) expression treated with 177Lu-DOTA-octreotate, 9 with radiosensitising chemotherapy, were retrospectively reviewed...
June 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28566531/sdhb-mutation-carriers-with-malignant-pheochromocytoma-respond-better-to-cvd
#7
Lauren Fishbein, Sivan Ben-Maimon, Stephen Keefe, Keith Cengel, Daniel A Pryma, Arturo Loaiza-Bonilla, Douglas L Fraker, Katherine L Nathanson, Debbie L Cohen
Pheochromocytomas and paragangliomas (PCC/PGL) are tumors in the adrenal medulla and extra adrenal sites, respectively. About a quarter are metastatic, often with a long latency period. Some PCC/PGL are defined as clinically aggressive given extensive local invasion into adjacent normal tissue. These tumors, like metastatic PCC/PGL, cannot be surgically cured and patients can have continued secretion of excessive catecholamines with all related sequelae. For patients with metastatic or aggressive tumors, treatment options are limited...
May 31, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28506066/de-novo-computational-design-for-development-of-a-peptide-ligand-oriented-to-vegfr-3-with-high-affinity-and-long-circulation
#8
Hong M Li, Zhi P Dong, Qi Y Wang, Li X Liu, Bing X Li, Xiao N Ma, Ming S Lin, Tao Lu, Yue Wang
The overexpression of VEGFR-3 is correlated with a worse prognosis in lung cancer and has been regarded as a rational target for specific drug delivery. Here, VEGFR-3 homing peptide library was efficiently established by computational design. Strong fluorescent signals of selected peptides were observed in A549 cells, but much weaker in other cells. The positive immunostaining overlapped with VEGFR-3 confirmed high affinity and selectivity of one novel peptide (CP-7). In addition, cell uptake of FITC-CP-7 peptide was significantly blocked by coinjection of excess CP-7 peptide...
May 31, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28482084/response-to-letter-postoperative-thyroglobulin-and-neck-ultrasound-in-the-risk-restratification-and-decision-to-perform-131i-ablation
#9
Rossella Elisei, Francesca Binchi, Antonio Matrone
No abstract text is available yet for this article.
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28482079/letter-to-the-editor-postoperative-thyroglobulin-and-neck-ultrasound-in-the-risk-restratification-and-decision-to-perform-131i-ablation
#10
Luca Giovanella, Luca Ceriani, Pierpaolo Trimboli
No abstract text is available yet for this article.
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28430648/radioimmunotherapy-for-cd133-colonic-cancer-stem-cells-inhibits-tumor-development-in-nude-mice
#11
Dinghu Weng, Xueyan Jin, Saimei Qin, Xiaoli Lan, Chong Chen, Xun Sun, Xianliang She, Changling Dong, Rui An
Accumulating evidence indicates that cancer stem cells (CSCs) are the cause of tumor drug/radio-resistance or distant metastasis; therefore, it is essential to eliminate CSCs to cure cancer completely. The purpose of this study was to utilize radioimmunotherapy (RIT) to target CD133(+) colonic CSCs and observe whether this prevented tumor development, by assessing the maximum tolerated dose (MTD) of HCT116 tumor-bearing nude mice with escalating doses of 131I-AC133.1 monoclonal antibody (mAb), and determining the therapeutic efficacy of RIT with 131I-AC133...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28393196/preparation-of-human-single-chain-variable-fragment-antibodies-against-anaplastic-thyroid-carcinoma-and-single-photon-emission%C3%A2-computed-tomography-computed-tomography-imaging-in-tumor-bearing-nude-mice
#12
Qian Liu, Hua Pang, Qiong Liu, Jing Zhou, Ying Liu
Anaplastic thyroid carcinoma (ATC) is the most aggressive malignant thyroid tumor with the worst prognosis, and the response to treatment is poor. We investigated soluble human single-chain variable fragment (scFv) which provides unique information for diagnostics, and for monitoring and optimizing responses to therapy. Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression of scFv. The expression and relative molecular mass of soluble scFv were assessed by sodium dodecyl sulfate‑polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting, respectively...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28380420/imaging-and-targeted-therapy-of-pancreatic-ductal-adenocarcinoma-using-the-theranostic-sodium-iodide-symporter-nis-gene
#13
Kathrin A Schmohl, Aayush Gupta, Geoffrey K Grünwald, Marija Trajkovic-Arsic, Kathrin Klutz, Rickmer Braren, Markus Schwaiger, Peter J Nelson, Manfred Ogris, Ernst Wagner, Jens T Siveke, Christine Spitzweg
The theranostic sodium iodide symporter (NIS) gene allows detailed molecular imaging of transgene expression and application of therapeutic radionuclides. As a crucial step towards clinical application, we investigated tumor specificity and transfection efficiency of epidermal growth factor receptor (EGFR)-targeted polyplexes as systemic NIS gene delivery vehicles in an advanced genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC) that closely reflects human disease. PDAC was induced in mice by pancreas-specific activation of constitutively active KrasG12D and deletion of Trp53...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28380100/short-and-long-term-effects-of-zinc-treatment-on-lacrimal-gland-histopathology-and-tear-functions-tests-in-radioiodine-administered-rats
#14
Firdevs Ornek, Damla Erginturk Acar, Ugur Acar, Ozdemir Ozdemir, Hasan Ikbal Atilgan, Nihat Yumusak, Basak Boztok Ozgermen
Purpose: To investigate the short-term (1 week) and long-term (8 weeks) protective effects of zinc administration on radioiodine (RAI)-induced lacrimal gland damage of rats. Methods: A total of 40 rats were divided into two groups: an RAI group (n=20), which was administrated a single dose of 3 mCi of 131I and 1 mL physiologic saline for 7 days by gastric gavage, and a zinc group (n=20), which received a single dose of 3 mCi of 131I and 1 mL of physiologic saline containing zinc sulfate at a concentration of 10 mg/kg concentration for 7 days by gastric gavage...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28372461/decontamination-of-rat-and-human-skin-experimentally-contaminated-with-99m-tc-201-tl-and-131-i-radionuclides-using-dermadecon-a-skin-decontamination-kit-an-efficacy-study
#15
Dhruv Kumar Nishad, Supriya Bhalla, Kushagra Khanna, Braj Gaurav Sharma, Harish Singh Rawat, Gaurav Mittal, Aseem Bhatnagar
Radioactive skin contamination is one of the most likely risks which occurs after accidental or occupational radiological accidents apart from internal contamination. In such cases where the radioactive contamination has occurred, the person who is contaminated should be decontaminated as early as possible to reduce the damaging health effects of radiation. In the present study, the decontamination efficiency of a developed skin decontamination kit "dermadecon" has been evaluated in animal models and human subjects using gamma scintigraphy...
May 3, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28296315/effective-method-of-measuring-the-radioactivity-of-%C3%A2-131i-capsule-prior-to-radioiodine-therapy-with-significant-reduction-of-the-radiation-exposure-to-the-medical-staff
#16
Ulf Lützen, Yi Zhao, Marlies Marx, Thea Imme, Isong Assam, Frank-Andre Siebert, Juraj Culman, Maaz Zuhayra
Radiation Protection in Radiology, Nuclear Medicine and Radio Oncology is of the utmost importance. Radioiodine therapy is a frequently used and effective method for the treatment of thyroid disease. Prior to each therapy the radioactivity of the [ 131I]-capsule must be determined to prevent misadministration. This leads to a significant radiation exposure to the staff. We describe an alternative method, allowing a considerable reduction of the radiation exposure. Two [ 131I]-capsules (A01=2818.5; A02=73...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28252265/comparison-of-curative-effect-of-131i-and-antithyroid-drugs-in-graves-disease-a-meta-analysis
#17
Ju Yuan, Xiuqing Lu, Yan Yue
BACKGROUND: Radioactive 131I is currently reported to be a potential effective intervention for Graves' Disease treatment in China. Whether 131I treatment was associated with effective outcome or reduced risk of side effects, reccurence rate remained unknown. EVIDENCE ACQUISITION: Eligible studies were selected from Chinese VIP, Wangfang, CNKI databases using the keywords "Iodine" and "Graves Disease". Finally, 13 clinical trials met the inclusion criterion and were included this meta-analysis...
March 1, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28222107/transcriptional-response-to-131i-exposure-of-rat-thyroid-gland
#18
Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Humans are exposed to 131I in medical diagnostics and treatment but also from nuclear accidents, and better knowledge of the molecular response in thyroid is needed. The aim of the study was to examine the transcriptional response in thyroid tissue 24 h after 131I administration in rats. The exposure levels were chosen to simulate both the clinical situation and the case of nuclear fallout. Thirty-six male rats were i.v. injected with 0-4700 kBq 131I, and killed at 24 h after injection (Dthyroid = 0.0058-3...
2017: PloS One
https://www.readbyqxmd.com/read/28207853/numerical-simulations-of-atmospheric-dispersion-of-iodine-131-by-different-models
#19
Ádám Leelőssy, Róbert Mészáros, Attila Kovács, István Lagzi, Tibor Kovács
Nowadays, several dispersion models are available to simulate the transport processes of air pollutants and toxic substances including radionuclides in the atmosphere. Reliability of atmospheric transport models has been demonstrated in several recent cases from local to global scale; however, very few actual emission data are available to evaluate model results in real-life cases. In this study, the atmospheric dispersion of 131I emitted to the atmosphere during an industrial process was simulated with different models, namely the WRF-Chem Eulerian online coupled model and the HYSPLIT and the RAPTOR Lagrangian models...
2017: PloS One
https://www.readbyqxmd.com/read/28166158/interrupted-131i-procedures-for-patients-with-differentiated-thyroid-cancer-comparing-thyroxine-withdrawal-with-recombinant-thyrotropin-preparation-techniques
#20
COMPARATIVE STUDY
Shawn Karls, Gad Abikhzer, Michael Tamilia, Stephan Probst
OBJECTIVE: In patients with differentiated thyroid carcinoma scheduled to receive doses of I for diagnostic or therapeutic purposes, we compared patients prepared with thyroid hormone withdrawal (THW) versus recombinant human thyroid stimulating hormone (rh-TSH) to evaluate the incidence of cancelled procedures because of inadequate thyroid stimulation. METHODS: Thyroid cancer patients after thyroidectomy who were scheduled for diagnostic or therapeutic I procedures between January 2012 and June 2015 were retrospectively reviewed...
April 2017: Clinical Nuclear Medicine
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