keyword
MENU ▼
Read by QxMD icon Read
search

131I

keyword
https://www.readbyqxmd.com/read/27902975/timing-of-hormone-withdrawal-in-children-undergoing-131i-whole-body-scans-for-thyroid-cancer
#1
Sophie Turpin, Raymond Lambert, Cheri Deal
BACKGROUND: Little objective pediatric data exist to guide the optimal time needed to achieve thyroid-stimulating hormone (TSH) levels ≥30 μIU/mL prior to performing 131I or 123I whole-body scan (WBS) imaging in children with thyroid cancer in the post-thyroidectomy period or after hormone discontinuation. METHODS: Retrospective study of patients aged 5-19 years who underwent WBS. Patient data collection included type and duration of withdrawal (liothyronine [L-T3], levothyroxine [L-T4], or post-thyroidectomy status without hormonal replacement) and TSH measured prior to WBS (level and timing)...
December 1, 2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27856495/clinical-outcomes-of-a-cohort-of-patients-with-central-nervous-system-metastases-from-thyroid-cancer
#2
Joana Simões-Pereira, Daniel Macedo, Maria João Bugalho
INTRODUCTION: Metastases to central nervous system (M1-CNS) are rarely reported in thyroid cancer (TC) patients. We aimed to characterize patients with M1-CNS from TC followed in our department. METHODS: Review of the medical records of 27 patients with TC-related M1-CNS. RESULTS: Mean age at TC diagnosis was 56.9 ± 19.1 years. Papillary TC (55.6%) was the commonest histological type, followed by poorly differentiated (18.5%), medullary (11...
November 2016: Endocrine Connections
https://www.readbyqxmd.com/read/27852633/predictors-of-malignancy-in-patients-with-pheochromocytomas-paragangliomas-asian-indian-experience
#3
Kranti Khadilkar, Vijaya Sarathi, Rajeev Kasaliwal, Reshma Pandit, Manjunath Goroshi, Gaurav Malhotra, Abhay Dalvi, Ganesh Bakshi, Anil Bhansali, Rajesh Rajput, Vyankatesh Shivane, Anurag Ranjan Lila, Tushar Ramkrishna Bandgar, Nalini Shah
BACKGROUND AND AIMS: Malignant transformation of pheochromocytomas/paragangliomas (PCC/PGL) is a rare occurrence and predictive factors for the same are not well understood. This study aims to identify predictors of malignancy in patients with PCC/PGL. MATERIALS AND METHODS: We performed a retrospective analysis of 142 patients with either PCC or PGL registered at our institute between 2000 and 2015. Records were evaluated for clinical parameters like age, gender, familial/syndromic presentation, symptomatic presentation, biochemistry, size, number and location of tumours and presence of metastases and mode of its diagnosis...
November 16, 2016: Endocrine Connections
https://www.readbyqxmd.com/read/27846002/renal-metastasis-from-primary-thyroid-cancer-on-131i-and-mri-imaging
#4
Darshan R Patel, Bhishak H Kamat, Michael D Farwell
A 66-year-old woman with a history of papillary thyroid cancer status after total thyroidectomy underwent I radioiodine ablation therapy 3 months after surgery. Posttherapy whole body planar imaging revealed focal intense I uptake in the posterior right abdomen. SPECT/CT of this region localized the uptake to the medial lower pole of the right kidney. Further evaluation with MRI demonstrated a correlative suspicious right renal mass. The patient underwent right partial nephrectomy with pathology demonstrating that the renal mass was of thyroidal origin (papillary subtype)...
November 11, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27844413/relationship-between-circulating-anti-thyroglobulin-antibodies-tgab-and-tumor-metabolism-in-patients-with-differentiated-thyroid-cancer-dtc-prognostic-implications
#5
S Morbelli, G Ferrarazzo, E Pomposelli, F Pupo, G Pesce, I Calamia, F Fiz, A Clapasson, M Bauckneht, M Minuto, G Sambuceti, M Giusti, M Bagnasco
PURPOSE: TgAb have been proposed as tumor markers in DTC. Recent evidence links TgAb levels with DTC aggressiveness. We aimed to evaluate the relationship between TgAb and tumor glucose metabolism in DTC patients. METHODS: Seventy-one DTC patients who underwent (18)F-FDG PET/CT were included. According to TgAb value and trends, patients were divided into TgAb positive (TgAb+) or negative (TgAb-) as well as in patients with increasing (Inc-TgAb) or decreasing (Dec-TgAb) trend...
November 14, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27802029/an-integrative-folate-based-metal-complex-nanotube-as-a-potent-antitumor-nanomedicine-as-well-as-an-efficient-tumor-targeted-drug-carrier
#6
Lixiang Liu, Bingxia Li, Qiyan Wang, Zhipeng Dong, Hongmei Li, Qiaomei Jin, Hao Hong, Jian Zhang, Yue Wang
Metal-organic complexes (MOCs) are emerging developing functional materials, the different categories of metal ions and organic biomolecules provide great possibilities for the morphologies, sizes and properties of the products. Enlightened by the previous works of folate-nickel nanotubes (FA-Ni NTs), herein, a series of metal ions are tested to coordinate with folate (FA) by solvothermal method, among which folate-cobalt (2+) complex is formed to be a scaffold for the nanotube with the length of 150-500 nm and inner diameter of 6-11 nm, while the other metal ions fail...
November 1, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27775934/ganglion-cyst-on-131i-whole-body-scintigraphy
#7
Anunita Khasgiwala, Kent P Friedman, Munir Ghesani, Roy A Raad
Interpretation of iodine I whole-body scintigraphy can be challenging, as there are many nonpathologic findings that may present with increased radiotracer uptake. Radiotracer uptake has been reported in the literature involving the salivary glands, thymus, renal cysts, skin contamination, and other benign etiologies. We present the case of an incidental right wrist ganglion cyst demonstrating persistent increased uptake on I whole-body scintigraphy.
October 21, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27751975/adverse-reactions-to-radioiodine-131i-therapy-of-goiter-in-west-african-tertiary-hospital
#8
Yetunde A Onimode, John E Ejeh, Akintunde T Orunmuyi
OBJECTIVE: Radioactive iodine therapy (RAIT) is established as an efficient means of treating toxic goiter (TG) globally. The field of nuclear medicine (NM) still appears novel to many Nigerian clinicians and patients. A culturally embedded dread of radiation may raise ethical and moral concerns about potential adverse effects in the wake of RAIT in our setting. An adverse drug reaction may be described as "a response to a drug which is noxious and unintended, and which occurs at doses normally used in man"...
October 5, 2016: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/27749419/131i-and-124i-accumulation-in-a-thymic-cyst
#9
Tom Wilhelm, Thomas Winkens, Almut Kunze, Martin Freesmeyer
A 65-year-old woman presented with increased human thyroglobulin (3.3 ng/mL) 5 years after resection of a papillary thyroid carcinoma and successful I radioiodine therapy. I whole-body scintigraphy showed a small focus ventrally in the right lower neck, leading to suspicion of a papillary thyroid carcinoma recurrence. I-PET/CT and real-time PET/US fusion matched to a small hypoechoic/anechoic ovoid structure situated between the right sternoclavicular joint and the brachiocephalic trunk. After surgical resection, histology allowed a diagnosis of thymic cyst...
October 5, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27734699/-thyroid-hormones-and-cardiovascular-system
#10
Zdeňka Límanová, Jan Jiskra
Cardiovascular system is essentially affected by thyroid hormones by way of their genomic and non-genomic effects. Untreated overt thyroid dysfunction is associated with higher cardiovascular risk. Although it has been studied more than 3 decades, in subclinical thyroid dysfunction the negative effect on cardiovascular system is much more controversial. Large meta-analyses within last 10 years have shown that subclinical hyperthyroidism is associated with higher cardiovascular risk than subclinical hypothyroidism...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27592576/-analysis-on-clinical-characteristics-of-primary-hypothyroidism-induced-mental-disorder
#11
Jinhua Fu, Hongping Wei, Xiaojuan Li
OBJECTIVE: To summarize the clinical features and early diagnostic evidence for mental disorders due to primary hypothyroidism after primary overactive thyroid surgery or 131I therapy. 
 METHODS: The retrospective analysis was conducted on 15 patients in terms of the clinical features with primary hypothyroidism-induced mental disorder after primary overactive thyroid surgery or 131I therapy. The data regarding past history of hyperthyroidism parallel operation or 131I treatment, thyroid function biochemical indexes were collected...
July 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27588323/rate-of-elimination-of-radioiodine-avid-lymph-node-metastases-of-differentiated-thyroid-carcinoma-by-postsurgical-radioiodine-ablation-a-bicentric-study
#12
Harun Ilhan, Mona Mustafa, Peter Bartenstein, Torsten Kuwert, Daniela Schmidt
: SPECT/CT detects radioiodine-positive cervical lymph node metastases (LNMs) of differentiated thyroid carcinoma (DTC) at the time of postsurgical radioablation (RA). Preliminary evidence indicates that the majority of LNMs are successfully treated by RA. The aim of this study was to confirm this evidence in a bicentric setting and to evaluate whether size is a predictor for successful elimination. PATIENTS AND METHODS: Since 01/2007 and 05/2008, respectively, SPECT/spiral-CT is performed routinely in all patients with DTC at RA in two University Clinics...
September 2, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27585492/-131i-and-99mtc-uptake-in-focal-thyroid-autonomies-development-in-germany-since-the-1980s
#13
Christian Happel, W Tilman Kranert, Benjamin Bockisch, Hüdayi Korkusuz, Frank Grünwald
: Germany has developed into a country with a nationwide largely sufficient iodine supply due to improved alimentary iodine supply. The reduction of iodine uptake in focal autonomies induced by reduced iodine avidity was evaluated by Gotthardt et al. 2006, showing a significant decline of pertechnetate uptake up to the year 2004. AIM: This study was intended to carry this investigation forward to the present day to analyze the course of a conjectural stabilization of iodine uptake values...
September 2, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27576533/parameters-influencing-curative-effect-of-131i-therapy-on-pediatric-differentiated-thyroid-carcinoma-a-retrospective-study
#14
Lu Xu, Qiong Liu, Ying Liu, Hua Pang
BACKGROUND This study aimed to investigate the parameters influencing the effectiveness of first 131I thyroid remnant ablation and then 131I treatment of metastatic lesions in children and adolescents with differentiated thyroid carcinoma (DTC). MATERIAL AND METHODS A total of 88 children and adolescents with DTC were divided into 2 groups: 56 in the complete-ablation group and 32 in the incomplete-ablation group for the first 131I ablation; 32 in the incomplete-ablation group were further divided: 19 in the complete-remission group and 13 in the incomplete-remission group for subsequent 131I treatment of metastatic lesions...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27531898/combretastatin-a4-phosphate-improves-the-distribution-and-antitumor-efficacy-of-albumin-bound-paclitaxel-in-w256-breast-carcinoma-model
#15
Meng Gao, Dongjian Zhang, Qiaomei Jin, Cuihua Jiang, Cong Wang, Jindian Li, Fei Peng, Dejian Huang, Jian Zhang, Shaoli Song
Nanomedicine holds great promise for fighting against malignant tumors. However, tumor elevated interstitial fluid pressure (IFP) seriously hinders convective transvascular and interstitial transport of nanomedicines and thus damages its antitumor efficacy. In this study, combretastatin-A4 phosphate (CA4P) was utilized to reduce tumor IFP, and thereby to improve the intratumoral distribution and antitumor efficacy of nanoparticle albumin-bound paclitaxel (nab-paclitaxel). IFP was measured using the wick-in-needle method in tumors growing subcutaneously pretreatment and posttreatment with a single intravenous injection of CA4P...
August 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27498452/pheochromocytoma-of-the-urinary-bladder-a-case-report
#16
Predrag Marić, Novak Milović, Vladimir Bancević, Branko Kosević, Predrag Aleksić, Snezana Kuzmić Janković, Zoran Hajduković, Bosko Milev, Snezana Cerović
INTRODUCTION: Pheochromocytoma of the urinary bladder is a rare tumor and presents less than 0.06% of all urinary bladder tumors. CASE REPORT: We presented a 49-year-old female patient with a history of daily paroxysmal hypertension accompanied with flushing of the face and upper chest, palpitations and excessive sweating prior to micturition. Ultrasonography reported a 3 cm bladder wall tumor. The 131I-metaiodobenzylguanidine (131I-MIBG) scan showed a pathological isotope accumulation in the projection of the bladder...
June 2016: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/27458162/hypoxia-targeted-131i-therapy-of-hepatocellular-cancer-after-systemic-mesenchymal-stem-cell-mediated-sodium-iodide-symporter-gene-delivery
#17
Andrea M Müller, Kathrin A Schmohl, Kerstin Knoop, Christina Schug, Sarah Urnauer, Anna Hagenhoff, Dirk-André Clevert, Michael Ingrisch, Hanno Niess, Janette Carlsen, Christian Zach, Ernst Wagner, Peter Bartenstein, Peter J Nelson, Christine Spitzweg
Adoptively transferred mesenchymal stem cells (MSCs) home to solid tumors. Biologic features within the tumor environment can be used to selectively activate transgenes in engineered MSCs after tumor invasion. One of the characteristic features of solid tumors is hypoxia. We evaluated a hypoxia-based imaging and therapy strategy to target expression of the sodium iodide symporter (NIS) gene to experimental hepatocellular carcinoma (HCC) delivered by MSCs.MSCs engineered to express transgenes driven by a hypoxia-responsive promoter showed robust transgene induction under hypoxia as demonstrated by mCherry expression in tumor cell spheroid models, or radioiodide uptake using NIS...
July 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27455475/effective-method-of-measuring-the-radioactivity-of-131i-capsule-prior-to-radioiodine-therapy-with-significant-reduction-of-the-radiation-exposure-to-the-medical-staff
#18
Ulf Lützen, Yi Zhao, Malies Marx, Thea Imme, Isong Assam, Frank-Andre Siebert, Juaraj Culman, Maaz Zuhayra
Radiation Protection in Radiology, Nuclear Medicine and Radio Oncology is of the utmost importance. Radioiodine therapy is a frequently used and effective method for the treatment of thyroid disease. Prior to each therapy the radioactivity of the [131I]-capsule must be determined to prevent misadministration. This leads to a significant radiation exposure to the staff. We describe an alternative method, allowing a considerable reduction of the radiation exposure. Two [131I]-capsules (A01 = 2818.5; A02 = 7355...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27440185/pet-radiopharmaceuticals-for-personalized-medicine
#19
Sushil K Sharma
Recent advances in the self-shielded cyclotrons, improved targets, video-monitored hot cells design, and automated PET radiopharmaceutical (RPs) synthesis modules, utilizing computer-controlled graphic user interphase (GUI) has revolutionized PET molecular imaging technology for basic biomedical research and theranostics to accomplish the ultimate goal of evidence-based personalized medicine. Particularly, [18F]HX4: (3-[18F]fluoro-2-(4-((2-nitro-1Himidazol-1-yl)methyl)-1H-1,2,3,-triazol-1-yl)-propan-1-ol), 18F-FAZA: 1-(5-[18F]Fluoro-5-deoxy-α-D-arabinofuranosyl)-2-nitroimidazole, and 18F-FMSIO: 18F-Ffluoromisonidazole to assess tumor hypoxia, [18F]FB-VAD-FMK: [18F]4-fluorobenzylcarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone to determine in vivo apoptosis, 64Cu-PTSM: 64Cu-Pyrualdehyde Bis-N-Methylthiosemicarbazone for brain and myocardial perfusion imaging, and 68Ga-DOTATOC: 68Ga-DOTAD-Phy1-Tyr3-octreotide and 68Ga-DOTANOC: 68Ga-(1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid)-1-NaI3-octreotide for neuroendocrine and neural crest tumors have demonstrated great promise in personalized theranostics...
July 19, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27363025/regression-of-experimental-nis-expressing-breast-cancer-brain-metastases-in-response-to-radioiodide-gemcitabine-dual-therapy
#20
Corinne Renier, John Do, Andrea Reyna-Neyra, Deshka Foster, Abhijit De, Hannes Vogel, Stefanie S Jeffrey, Victor Tse, Nancy Carrasco, Irene Wapnir
Treating breast cancer brain metastases (BCBMs) is challenging. Na+/I- symporter (NIS) expression in BCBMs would permit their selective targeting with radioiodide (131I-). We show impressive enhancement of tumor response by combining131I- with gemcitabine (GEM), a cytotoxic radiosensitizer. Nude mice mammary fat-pad (MFP) tumors and BCBMs were generated with braintropic MDA-MB-231Br cells transduced with bicistronically-linked NIS and firefly luciferase cDNAs. Response was monitored in vivo via bioluminescent imaging and NIS tumor expression...
June 23, 2016: Oncotarget
keyword
keyword
58228
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"