keyword
MENU ▼
Read by QxMD icon Read
search

131I

keyword
https://www.readbyqxmd.com/read/29768630/what-determines-mortality-in-malignant-pheochromocytoma-report-of-a-case-with-eighteen-year-survival-and-review-of-the-literature
#1
Matheus de Oliveira Andrade, Vinícius Santos da Cunha, Dayana Carla de Oliveira, Olívia Laquis de Moraes, Adriana Lofrano-Porto
Pheochromocytoma (PCC) is a tumor derived from adrenomedullary chromaffin cells. Prognosis of malignant PCC is generally poor due to local recurrence or metastasis. We aim to report a case of malignant PCC with 18-year survival and discuss which factors may be related to mortality and long-term survival in malignant pheochromocytoma. The patient, a 45-year-old man, reported sustained arterial hypertension with paroxysmal episodes of tachycardia, associated with head and neck burning sensation, and hand and foot tremors...
March 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29694635/outcomes-of-patients-with-bone-metastases-from-differentiated-thyroid-cancer
#2
Inés Califano, Susana Deutsch, Alicia Löwenstein, Carmen Cabezón, Fabián Pitoia
Objective Bone metastases (BM) from differentiated thyroid cancer (DTC) are associated with poor survival rates. Due to the low frequency of this entity, we performed a multicentric retrospective study that aimed to evaluate the presentation, outcome and causes of death in this population. Subjects and methods We reviewed file records from 10 databases. BM were diagnosed by: i) biopsy and/or ii) radioiodine (RAI) bone uptake + elevated thyroglobulin (Tg) levels and/or c) bone uptake of 18-FDG in the PET-CT scan + elevated Tg levels...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29658563/preclinical-evaluation-of-a-novel-engineered-recombinant-human-anti-cd44v6-antibody-for-potential-use-in-radio-immunotherapy
#3
Anja C Mortensen, Diana Spiegelberg, Anna-Karin Haylock, Hans Lundqvist, Marika Nestor
CD44v6 is overexpressed in a variety of cancers, rendering it a promising target for radio-immunotherapy (RIT). In this study, we have characterized a novel engineered recombinant monoclonal anti-CD44v6 antibody, AbN44v6, and assessed its potential for use in RIT using either 177Lu or 131I as therapeutic radionuclides. In vitro affinity and specificity assays characterized the binding of the antibody labeled with 177Lu, 125I or 131I. The therapeutic effects of 177Lu-AbN44v6 and 131I-AbN44v6 were investigated using two in vitro 3D tumor models with different CD44v6 expression...
April 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29652748/the-scintigraphic-biodistribution-and-histopathological-evaluation-of-the-effect-of-experimental-131i-administration-on-the-gastrointestinal-system-and-the-demonstration-of-the-na-i-symporter-by-immunohistochemistry-in-rats
#4
Rahsan Yilmaz, Nihat Yumusak, Murat Sadic, Hasan I Atilgan, Meliha Korkmaz, Faruk Bozkaya
OBJECTIVE: The aim of this study was to investigate histopathological changes and biodistribution of iodine-131 (I) in the gastrointestinal system (GIS) and also Na/I Symporter (NIS) presence by immunohistochemically in the experimental treatment of rats with radioactive iodine (RAI). MATERIALS AND METHODS: Rats were divided into experimental and control groups as random early group 2 (24 h), intermediate group 3 (3 weeks), and late period group 4 (3 months). Experimental groups were administered 100 MBq (∼3 mCi, 12 mCi/kg) by orogastric route with orogastric tube...
April 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29618130/131i-dose-estimation-from-intake-of-tap-water-in-the-early-phase-after-fukushima-daiichi-nuclear-power-plant-accident
#5
Masaki Kawai, Nobuaki Yoshizawa, Gen Suzuki
In March 2011, the Fukushima Daiichi Nuclear Power Plant Accident occurred and a large amount of radionuclides was released. To study its effect, we estimated the internal exposure due to intake of tap water in the early phase after the accident. As the number of measured values of tap water following the accident was limited, 131I concentration in tap water was estimated by 1-compartment model using the deposition amount of radionuclides calculated by an atmospheric transport, dispersion and deposition simulation...
April 1, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29590674/-influence-of-glucocorticoid-therapy-on-intratherapeutic-biodistribution-of-131i-radioiodine-therapy-in-graves-disease
#6
Jörg Halstenberg, Wolfgang Tilman Kranert, Hüdayi Korkusuz, Amelie Mayer, Hanns Ackermann, Frank Grünwald, Christian Happel
AIM: Radioiodine therapy (RIT) is an important therapeutic method in the definitive treatment of Graves' disease (GD). However, RIT may trigger development of Graves' ophthalmopathy (GO) or exacerbate a pre-existing GO. Therefore, the procedure recommendation of the DGN (German Society of Nuclear Medicine) for RIT of benign thyroid diseases recommends an additional glucocorticoid therapy for patients with pre-existing GO. Aim of this study was to analyze the influence of a protective glucocorticoid therapy on131 I biokinetics during RIT of patients with GD...
April 2018: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/29584908/methodology-at-ciemat-whole-body-counter-for-in-vivo-monitoring-of-radioiodine-in-the-thyroid-of-exposed-population-in-case-of-nuclear-emergency
#7
B Pérez López, J F Navarro, M A López
Iodine-131 is one of the main concerns from the point of view of radiological protection in a short term after a nuclear accident. The WBC Laboratory of CIEMAT has developed a methodology for in vivo monitoring of radioiodine in the thyroid of exposed individuals in case of emergency. Thyroid-neck phantoms of different sizes are required for calibrating the detection systems in appropriate counting geometries for the measurement of exposed population. A Low-Energy Germanium (LEGe) detector and a Fastscan Counter were calibrated using a set of thyroid phantoms fabricated by CIEMAT...
March 23, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29579409/the-effect-of-131i-induced-hypothyroidism-on-the-levels-of-nitric-oxide-no-interleukin-6-il-6-tumor-necrosis-factor-alpha-tnf-%C3%AE-total-nitric-oxide-synthase-nos-activity-and-expression-of-nos-isoforms-in-rats
#8
Jing Zhou, Gang Cheng, Hua Pang, Qian Liu, Ying Liu
Accumulating evidence has shown that hypothyroidism affects the cardiovascular system, significantly increasing the incidence of cardiovascular diseases. In the present study we investigated the effect of radioactive iodine (I-131)-induced hypothyroidism on several parameters of vascular function, such as nitric oxide (NO), total nitric oxide synthase (NOS) activity and expression of NOS isoforms, as well as on interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) as indicators of inflammation, in rats...
March 10, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29549769/hybrid-vision-fusion-system-for-whole-body-scintigraphy
#9
Marko Barjaktarović, Milica M Janković, Marija Jeremić, Milovan Matović
Radioiodine therapy in the treatment of differentiated thyroid carcinoma (DTC) is used in clinical practice for the ablation of thyroid residues and/or destruction of tumour tissue. Whole-body scintigraphy for visualization of the spatial 131I distribution performed by a gamma camera (GC) is a standard procedure in DTC patients after application of radioiodine therapy. A common problem is the precise topographic localization of regions where radioiodine is accumulated even in SPECT imaging. SPECT/CT can provide precise topographic localization of regions where radioiodine is accumulated, but it is often unavailable, especially in developing countries because of the high price of the equipment...
May 1, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29517576/pretherapeutic-124i-dosimetry-reliably-predicts-intratherapeutic-blood-kinetics-of-131i-in-patients-with-differentiated-thyroid-carcinoma-receiving-high-therapeutic-activities
#10
Marcus Ruhlmann, Wilfried Sonnenschein, James Nagarajah, Ina Binse, Ken Herrmann, Walter Jentzen
AIM: The aim of this study was to assess the agreement between predicted blood uptake values using I and actually measured I blood uptake values (reference) in patients with differentiated thyroid carcinoma receiving largely high therapeutic activities. PATIENTS AND METHODS: Fourteen patients were analyzed retrospectively, who underwent a series of both pretherapeutic and intratherapeutic blood sampling using median I activities of 23 MBq and median therapy I activities of 10 GBq...
May 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29517545/false-positive-uptake-of-131i-due-to-tubal-ligation-in-a-patient-with-papillary-thyroid-cancer
#11
Junyu Tong, Yuchen Jin, Min Liu, Zhongwei Lv, Libo Chen
A 39-year-old woman with papillary thyroid cancer underwent I therapy after thyroidectomy. Posttherapeutic I whole-body scan accidentally showed symmetric "hot spots" in the pelvic region beyond known bone metastases. SPECT/CT was immediately added and revealed metal artifacts with I accumulation in the nearby uterus. Further inquiry discovered that she underwent tubal ligation 19 years ago. Our case demonstrates that I accumulation can occur at the site of oviducts many years after tubal ligation, which should be distinguished from I-avid metastases...
May 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29504625/fractionated-dosage-of-radioiodine-for-the-ablation-of-differentiated-thyroid-cancer-has-no-impact-on-survival
#12
Kosma Woliński, Rafał Czepczyński, Adam Stangierski, Maciej Trojanowski, Magdalena Rewaj-Łosyk, Katarzyna Ziemnicka, Maciej Bączyk, Agnieszka Dyzmann-Sroka, Marek Ruchała
INTRODUCTION: Due to a limited number of hospital beds dedicated to radioiodine therapy (RIT) in some countries, a fractionated dose of radioiodine may be considered as the ablation therapy of differentiated thyroid cancer (DTC). The aim of the study was to compare the late effects of ablation therapy with single and fractionated dose of radioiodine in patients with DTC. PATIENTS AND METHODS: Patients with low-risk DTC referred to our institution 5-16 weeks after thyroidectomy, treated with 2...
March 5, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29485411/response-of-retinoic-acid-in-patients-with-radioactive-iodine-refractory-thyroid-cancer-a-meta-analysis
#13
Kyoungjune Pak, Seunghyeon Shin, Seong-Jang Kim, In-Joo Kim, Samuel Chang, Phillip Koo, Jennifer Kwak, Jae-Ho Kim
PURPOSE: The purpose of this study was to evaluate the response of retinoic acid (RA) in radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC). METHODS: Systematic searches of MEDLINE (from inception to December 2016) and of EMBASE (from inception to December 2016) were performed for English-language publications on thyroid cancer treated with RA. Studies were classified according to the response criteria used: (1) 123I or 131I whole body scintigraphy (WBS), (2) serum thyroglobulin (Tg) level, (3) the response evaluation criteria in solid tumors (RECIST) version 1...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29484944/risk-stratification-of-282-differentiated-thyroid-cancers-found-incidentally-in-1369-total-thyroidectomies-according-to-the-2015-ata-guidelines-implications-for-management-and-treatment
#14
I Christakis, S Dimas, I D Kafetzis, N Roukounakis
Introduction The purpose of this study was to evaluate the incidence of incidental differentiated thyroid carcinoma in thyroid operations for a benign preoperative diagnosis, to identify the risk factors involved and to risk stratify the cancer patients according to the 2015 American Thyroid Association (ATA) guidelines. Materials and methods The study was a retrospective review of all thyroidectomy operations performed in a single institution (January 2004 to January 2009). We excluded patients with a preoperative diagnosis of thyroid malignancy...
May 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29439614/effect-of-thyroglobulin-autoantibodies-on-the-metabolic-clearance-of-serum-thyroglobulin
#15
Francesco Latrofa, Debora Ricci, Sara Bottai, Federica Brozzi, Luca Chiovato, Paolo Piaggi, Michele Marinò, Paolo Vitti
BACKGROUND: In order to establish whether thyroglobulin autoantibodies (TgAb) influence the metabolic clearance of thyroglobulin (Tg) in humans, serum Tg and TgAb were correlated shortly after radioiodine (131 I) treatment. METHODS: Samples were collected from 30 consecutive patients undergoing 131 I activity for Graves' hyperthyroidism at the time of treatment and every 15 days thereafter, up to 90 days. Tg and TgAb were measured by immunometric assays (functional sensitivities: 0...
March 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29432588/method-for-occupational-skin-dose-estimation-in-upper-extremity-131i-mibg-contamination
#16
Dennise Magill, Natalie Beckmann, Marc Felice, Megan Harkins
This study examines upper extremity skin contamination of nuclear medicine and radiation safety staff during 131I-Metaiodobenzylguanidine (MIBG) therapy. Utilizing retrospective data, a methodology for performing a rapid assessment of the radiation dose to the skin of the upper extremities is presented. Using the skin contamination measurements and calculated skin dose for each contamination incident at our facility, a conversion factor (XE) was derived that estimates skin dose (DE) based on the initial contamination measurement...
February 8, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29430108/impact-of-the-amount-of-liquid-intake-on-the-dose-rate-of-patients-treated-with-radioiodine
#17
Mahdi Haghighatafshar, Aida Banani, Banafsheh Zeinali-Rafsanjani, Zahra Etemadi, Tahereh Ghaedian
Purpose: Despite therapeutic effects of radioiodine in patients with differentiated thyroid cancer, there are some disadvantages due to harmful radiation to other tissues. According to the current guidelines, patients are recommended to drink lots of water and frequent voiding to reduce the amount of 131 I in the body. This study was designed to assess the impact of the amount of liquid intake on reduction of the measured dose rate of radioiodine-treated patients. Materials and Methods: A total of 42 patients with differentiated thyroid cancer without metastasis who had undergone total thyroidectomy and had been treated with radioiodine were selected...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29422483/the-effects-of-isopropyl-methylphosphono-fluoridate-impf-poisoning-on-tumor-growth-and-angiogenesis-in-balb-c-mice
#18
Robert Zdanowski, Monika Leśniak, Urszula Karczmarczyk, Marek Saracyn, Marek Bilski, Anna Kiepura, Jacek Z Kubiak, Sławomir Lewicki
BACKGROUND Acetylcholinesterase (AChE) and cholinergic receptors have an important role in the immune system and angiogenesis. This work evaluated the effects of isopropyl methylphosphonofluoridate (IMPF), an irreversible inhibitor of AChE, on tumor growth and selected parameters associated with tumor angiogenesis. MATERIAL AND METHODS Experiments were performed on male BALB/c mice exposed to IMPF (study group) or saline buffer (control group) and inoculated with L-1 sarcoma; the number of new blood vessels (TIA test) and the level of αvβ3 integrin (131I-MAb-antiβ3 assay) were analyzed at seven, 14, or 21 days after implantation of the tumor cells...
February 9, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29420945/improved-approach-for-routine-monitoring-of-129-i-activity-and-129-i-127-i-atom-ratio-in-environmental-samples-using-tmah-extraction-and-icp-ms-ms
#19
Guosheng Yang, Hirofumi Tazoe, Masatoshi Yamada
To reconstruct 131 I deposition and identify the source of radioiodine due to the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, 129 I activity and 129 I/127 I atom ratio should be obtained by preparing and analyzing large numbers of samples economically. In this study, great efforts were made to realize mild TMAH (tetramethyl ammonium hydroxide) extraction of environmental samples at 90 °C to obtain solutions suitable for the following triple-quadrupole inductively coupled plasma-mass spectrometry (ICP-QQQ) MS/MS mode analysis...
May 30, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29415268/comparative-analysis-of-the-countermeasures-taken-to-mitigate-exposure-of-the-public-to-radioiodine-following-the-chernobyl-and-fukushima-accidents-lessons-from-both-accidents
#20
Vladimir Uyba, Alexander Samoylov, Sergey Shinkarev
In the case of a severe radiation accident at a nuclear power station, the most important radiation hazard for the public is internal exposure of the thyroid to radioiodine. The purposes of this paper were (i) to compare countermeasures conducted (following the Chernobyl and Fukushima accidents) aimed at mitigation of exposure to the thyroid for the public, (ii) to present comparative estimates of doses to the thyroid and (iii) to derive lessons from the two accidents. The scale and time of countermeasures applied in the early phase of the accidents (sheltering, evacuation, and intake of stable iodine to block the thyroid) and at a later time (control of 131I concentration in foodstuffs) have been described...
February 3, 2018: Journal of Radiation Research
keyword
keyword
58228
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"