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https://www.readbyqxmd.com/read/28430648/radioimmunotherapy-for-cd133-colonic-cancer-stem-cells-inhibits-tumor-development-in-nude-mice
#1
Dinghu Weng, Xueyan Jin, Saimei Qin, Xiaoli Lan, Chong Chen, Xun Sun, Xianliang She, Changling Dong, Rui An
Accumulating evidence indicates that cancer stem cells (CSCs) are the cause of tumor drug/radio-resistance or distant metastasis; therefore, it is essential to eliminate CSCs to cure cancer completely. The purpose of this study was to utilize radioimmunotherapy (RIT) to target CD133(+) colonic CSCs and observe whether this prevented tumor development, by assessing the maximum tolerated dose (MTD) of HCT116 tumor-bearing nude mice with escalating doses of 131I-AC133.1 monoclonal antibody (mAb), and determining the therapeutic efficacy of RIT with 131I-AC133...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28393196/preparation-of-human-single-chain-variable-fragment-antibodies-against-anaplastic-thyroid-carcinoma-and-single-photon-emission%C3%A2-computed-tomography-computed-tomography-imaging-in-tumor-bearing-nude-mice
#2
Qian Liu, Hua Pang, Qiong Liu, Jing Zhou, Ying Liu
Anaplastic thyroid carcinoma (ATC) is the most aggressive malignant thyroid tumor with the worst prognosis, and the response to treatment is poor. We investigated soluble human single-chain variable fragment (scFv) which provides unique information for diagnostics, and for monitoring and optimizing responses to therapy. Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression of scFv. The expression and relative molecular mass of soluble scFv were assessed by sodium dodecyl sulfate‑polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting, respectively...
April 5, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28380420/imaging-and-targeted-therapy-of-pancreatic-ductal-adenocarcinoma-using-the-theranostic-sodium-iodide-symporter-nis-gene
#3
Kathrin A Schmohl, Aayush Gupta, Geoffrey K Grünwald, Marija Trajkovic-Arsic, Kathrin Klutz, Rickmer Braren, Markus Schwaiger, Peter J Nelson, Manfred Ogris, Ernst Wagner, Jens T Siveke, Christine Spitzweg
The theranostic sodium iodide symporter (NIS) gene allows detailed molecular imaging of transgene expression and application of therapeutic radionuclides. As a crucial step towards clinical application, we investigated tumor specificity and transfection efficiency of epidermal growth factor receptor (EGFR)-targeted polyplexes as systemic NIS gene delivery vehicles in an advanced genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC) that closely reflects human disease. PDAC was induced in mice by pancreas-specific activation of constitutively active KrasG12D and deletion of Trp53...
March 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28380100/short-and-long-term-effects-of-zinc-treatment-on-lacrimal-gland-histopathology-and-tear-functions-tests-in-radioiodine-administered-rats
#4
Firdevs Ornek, Damla Erginturk Acar, Ugur Acar, Ozdemir Ozdemir, Hasan Ikbal Atilgan, Nihat Yumusak, Basak Boztok Ozgermen
Purpose: To investigate the short-term (1 week) and long-term (8 weeks) protective effects of zinc administration on radioiodine (RAI)-induced lacrimal gland damage of rats. Methods: A total of 40 rats were divided into two groups: an RAI group (n=20), which was administrated a single dose of 3 mCi of 131I and 1 mL physiologic saline for 7 days by gastric gavage, and a zinc group (n=20), which received a single dose of 3 mCi of 131I and 1 mL of physiologic saline containing zinc sulfate at a concentration of 10 mg/kg concentration for 7 days by gastric gavage...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28372461/decontamination-of-rat-and-human-skin-experimentally-contaminated-with-99mtc-201tl-131i-radionuclides-using-dermadecon-a-skin-decontamination-kit-an-efficacy-study
#5
Dhruv Kumar Nishad, Supriya Bhalla, Kushagra Khanna, Braj Gaurav Sharma, Harish Singh Rawat, Mittal Gaurav, Aseem Bhatnagar
Radioactive skin contamination is one of the most likely risks after accidental or occupational radiological accidents apart from internal contamination. In such cases where the radioactive contamination has occurred, the person contaminated should be decontaminated as soon as possible to reduce the damaging health effects of radiation. In present study, the decontamination efficiency of a developed skin decontamination kit 'Dermadecon' has been evaluated in animal models and human subjects using gamma scintigraphy...
April 3, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28296315/effective-method-of-measuring-the-radioactivity-of-%C3%A2-131i-capsule-prior-to-radioiodine-therapy-with-significant-reduction-of-the-radiation-exposure-to-the-medical-staff
#6
Ulf Lützen, Yi Zhao, Marlies Marx, Thea Imme, Isong Assam, Frank-Andre Siebert, Juraj Culman, Maaz Zuhayra
Radiation Protection in Radiology, Nuclear Medicine and Radio Oncology is of the utmost importance. Radioiodine therapy is a frequently used and effective method for the treatment of thyroid disease. Prior to each therapy the radioactivity of the [ 131I]-capsule must be determined to prevent misadministration. This leads to a significant radiation exposure to the staff. We describe an alternative method, allowing a considerable reduction of the radiation exposure. Two [ 131I]-capsules (A01=2818.5; A02=73...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28252265/comparison-of-curative-effect-of-131i-and-antithyroid-drugs-in-graves-disease-a-meta-analysis
#7
Ju Yuan, Xiuqing Lu, Yan Yue
BACKGROUND: Radioactive 131I is currently reported to be a potential effective intervention for Graves' Disease treatment in China. Whether 131I treatment was associated with effective outcome or reduced risk of side effects, reccurence rate remained unknown. EVIDENCE ACQUISITION: Eligible studies were selected from Chinese VIP, Wangfang, CNKI databases using the keywords "Iodine" and "Graves Disease". Finally, 13 clinical trials met the inclusion criterion and were included this meta-analysis...
March 1, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28222107/transcriptional-response-to-131i-exposure-of-rat-thyroid-gland
#8
Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Humans are exposed to 131I in medical diagnostics and treatment but also from nuclear accidents, and better knowledge of the molecular response in thyroid is needed. The aim of the study was to examine the transcriptional response in thyroid tissue 24 h after 131I administration in rats. The exposure levels were chosen to simulate both the clinical situation and the case of nuclear fallout. Thirty-six male rats were i.v. injected with 0-4700 kBq 131I, and killed at 24 h after injection (Dthyroid = 0.0058-3...
2017: PloS One
https://www.readbyqxmd.com/read/28207853/numerical-simulations-of-atmospheric-dispersion-of-iodine-131-by-different-models
#9
Ádám Leelőssy, Róbert Mészáros, Attila Kovács, István Lagzi, Tibor Kovács
Nowadays, several dispersion models are available to simulate the transport processes of air pollutants and toxic substances including radionuclides in the atmosphere. Reliability of atmospheric transport models has been demonstrated in several recent cases from local to global scale; however, very few actual emission data are available to evaluate model results in real-life cases. In this study, the atmospheric dispersion of 131I emitted to the atmosphere during an industrial process was simulated with different models, namely the WRF-Chem Eulerian online coupled model and the HYSPLIT and the RAPTOR Lagrangian models...
2017: PloS One
https://www.readbyqxmd.com/read/28166158/interrupted-131i-procedures-for-patients-with-differentiated-thyroid-cancer-comparing-thyroxine-withdrawal-with-recombinant-thyrotropin-preparation-techniques
#10
Shawn Karls, Gad Abikhzer, Michael Tamilia, Stephan Probst
OBJECTIVE: In patients with differentiated thyroid carcinoma scheduled to receive doses of I for diagnostic or therapeutic purposes, we compared patients prepared with thyroid hormone withdrawal (THW) versus recombinant human thyroid stimulating hormone (rh-TSH) to evaluate the incidence of cancelled procedures because of inadequate thyroid stimulation. METHODS: Thyroid cancer patients after thyroidectomy who were scheduled for diagnostic or therapeutic I procedures between January 2012 and June 2015 were retrospectively reviewed...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28165859/exercise-induced-hypoxemia-in-juvenile-thyroid-carcinoma-with-lung-metastases
#11
Florian J Segerer, Johannes Biko, Christoph Reiners, Clemens Wirth, Helge Hebestreit
PURPOSE: Exercise-induced arterial hypoxemia (EIAH) has been reported in patients with juvenile thyroid cancer treated with radioiodine for lung metastases. This retrospective study tested the hypothesis that EIAH is due to ventilation-perfusion-mismatch in this rare pulmonary condition. METHOD: 50 patients (age 13 -23 years) treated for juvenile thyroid carcinoma and lung metastasis with 131I and 24 controls with thyroid cancer but without lung metastases and prior 131I-treatment were assessed in a state of acute hypothyroidism by computed tomography of the lungs, pulmonary function testing, cardiopulmonary exercise test with measurements of gas exchange, oxygen saturation, alveolar-arterial difference in pO2 (p(A-a)O2) and pCO2 (p(ET-a)CO2)...
February 6, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28134695/multiple-endocrine-neoplasia-type-2b-unmasked-by-18f-fdg-pet-ct-and-131i-mibg-spect-ct
#12
Xun Sun, Maher Mohamad Rajab Arnous, Xiaoli Lan
F-FDG PET/CT was performed to detect an occult malignancy in a 26-year-old woman with complicated medical history which included paroxysmal hypertension and significantly elevated tumor marker. The images revealed lesions in the thyroid, lymph nodes, and bilateral adrenal glands. Further I-MIBG SPECT/CT revealed intense activity in the lesion in the left adrenal gland, which was consistent with pheochromocytoma. The pathology examination after subsequent neck biopsy demonstrated medullary thyroid carcinoma...
January 27, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28133244/-a-case-of-minimal-thyroid-carcinoma-diagnosed-by-a-solitary-pulmonary-metastasis
#13
Hiroshi Kawai, Ryoma Sugimoto, Norichika Iga, Hirokuni Ikeda, Ryosuke Yoshida, Naohisa Waki, Masahiro Ishizaki, Hideyuki Nishi, Kazuki Yamashita
We report a case of minimal thyroid carcinoma diagnosed by a solitary pulmonary metastasis. A 70's man visited a medical practitioner because of chest discomfort, and there was an abnormality on the chest X-ray. Chest computed tomography(CT) showed a nodule in the right middle lobe of the lung. Positron emission tomography with 18-fluorodeoxyglucose(FDG)-PET revealed increased FDG uptake in that tumor, but did not reveal any other lesion. The tumor was clinically suspected to be a carcinoid tumor, primary lung cancer, metastatic lung cancer, or a benign tumor...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28104741/recombinant-human-thyroid-stimulating-hormone-versus-thyroid-hormone-withdrawal-in-124i-pet-ct-based-dosimetry-for-131i-therapy-of-metastatic-differentiated-thyroid-cancer
#14
Donika Plyku, Robert F Hobbs, Kevin Huang, Frank Atkins, Carlos Garcia, George Sgouros, Douglas Van Nostrand
PURPOSE: Patients with metastatic differentiated thyroid cancer (DTC) may be prepared using either thyroid stimulating hormone withdrawal (THW) or recombinant human thyroid-stimulating hormone (rhTSH) injections prior to (131)I administration for treatment. The objective of this study was to compare the absorbed dose (D) to the critical organs and tumors determined by (124)I-Positron Emission Tomography/Computed Tomography (PET/CT) based dosimetry for (131)I therapy of metastatic DTC when the same patient was prepared with and imaged after both THW and rhTSH injections...
January 19, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28099584/iodine-131-treatment-of-thyroid-cancer-cells-leads-to-suppression-of-cell-proliferation-followed-by-induction-of-cell-apoptosis-and-cell-cycle-arrest-by-regulation-of-b-cell-translocation-gene-2-mediated-jnk-nf-%C3%AE%C2%BAb-pathways
#15
L M Zhao, A X Pang
Iodine-131 (131I) is widely used for the treatment of thyroid-related diseases. This study aimed to investigate the expression of p53 and BTG2 genes following 131I therapy in thyroid cancer cell line SW579 and the possible underlying mechanism. SW579 human thyroid squamous carcinoma cells were cultured and treated with 131I. They were then assessed for 131I uptake, cell viability, apoptosis, cell cycle arrest, p53 expression, and BTG2 gene expression. SW579 cells were transfected with BTG2 siRNA, p53 siRNA and siNC and were then examined for the same aforementioned parameters...
January 16, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28098666/estimated-internal-and-external-radiation-exposure-of-caregivers-of-patients-with-pediatric-neuroblastoma-undergoing-131i-metaiodobenzylguanidine-therapy-a-prospective-pilot-study
#16
Sangwon Han, Seon Hee Yoo, Kyung-Nam Koh, Jong Jin Lee
PURPOSE: Current recommendations suggest that family members should participate in the care of children receiving in-hospital I metaiodobenzylguanidine (MIBG) therapy for neuroblastoma. The present study aimed to measure the external radiation exposure and estimate the internal radiation exposure of caregivers during the hospital stay for I MIBG therapy. MATERIALS AND METHODS: Caregivers received radiation safety instructions and a potassium iodide solution for thyroid blockade before patient admission...
January 16, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28079570/incidental-gallbladder-cancer-visualized-from-posttreatment-131i-whole-body-scan-reply
#17
Chanika Sritara
No abstract text is available yet for this article.
March 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28049190/the-efficacy-of-rituximab-combined-with-131i-for-ophthalmic-outcomes-of-graves-ophthalmopathy-patients
#18
RANDOMIZED CONTROLLED TRIAL
Jiagen Li, Zhangsheng Xiao, Xianjie Hu, Yun Li, Xing Zhang, Songze Zhang, Weikun Gong, Jianqiang Zhao, Xuemei Ye
PURPOSE: The purpose of this study is to examine the effectiveness of introducing both rituximab (RTX) and 131I for active Graves' ophthalmopathy (GO) with hyperthyroidism. METHODS: In total, 217 patients suffering from active GO with hyperthyroidism were included in this research. All subjects were randomly assigned to 3 groups. Patients in group A solely received 131I treatment; group B1 underwent a methylprednisolone treatment in combination with 131I treatment; and group B2 received an RTX in combination with 131I treatment...
2017: Pharmacology
https://www.readbyqxmd.com/read/28033221/re-131i-and-124i-accumulation-in-a-thymic-cyst
#19
Paolo Zanotti-Fregonara, Elif Hindie
No abstract text is available yet for this article.
December 28, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28007013/dynamic-risk-estimates-of-outcome-in-chinese-patients-with-well-differentiated-thyroid-cancer-after-total-thyroidectomy-and-radioactive-iodine-remnant-ablation
#20
Feng-Chih Shen, Ching-Jung Hsieh, I-Chin Huang, Yen-Hsiang Chang, Pei-Wen Wang
BACKGROUND: This study was conducted to compare the staging systems for the prediction of long-term disease status in patients with well-differentiated thyroid carcinoma (WDTC), and to find out the earliest postoperative period predictor of long-term persistence/recurrence of disease. METHODS: Patients with WDTC (n = 356; Mage = 41.5 ± 12.7 years) followed for at least five years (12.3 ± 5.0 years) after thyroidectomy and (131)I remnant ablation at a tertiary regional hospital in Taiwan were retrospectively studied...
April 2017: Thyroid: Official Journal of the American Thyroid Association
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