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Myeloma metaanalysis

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https://www.readbyqxmd.com/read/23769670/risk-of-rash-associated-with-lenalidomide-in-cancer-patients-a-systematic-review-of-the-literature-and-meta-analysis
#1
REVIEW
Beatrice Nardone, Shenhong Wu, Benjamin C Garden, Dennis P West, Lilian M Reich, Mario E Lacouture
BACKGROUND: Lenalidomide is indicated for treatment of multiple myeloma in combination with dexamethasone and as a single agent in myelodysplastic syndromes. The incidence and risk of rash has been inconsistently reported. MATERIALS AND METHODS: We conducted a systematic review and metaanalysis of the literature to determine the incidence and risk of developing rash. Relevant studies were identified from PubMed and abstracts presented at American Society of Clinical Oncology annual meetings...
August 2013: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/18069273/-chemotherapy-for-multiple-myeloma
#2
REVIEW
Tadao Ishida
The combination of the melphalan and prednisolone (MP) can induce objective responses in about 50% of patients with multiple myeloma (MM) since its introduction in 1960. Since then many combination chemotherapy regimens have been used, but a large metaanalysis showed that the combination of oral MP is as effective as combination regimens including intravenous drugs. In recent years, many novel agents (including bortezomib, thalidomide, and liposomal doxorubicin) have been developed for the MM treatment. More recently, MP has been used in combination with these novel agents...
December 2007: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/10676551/multiple-myeloma-an-update-on-biology-and-treatment
#3
REVIEW
H Ludwig, J Meran, N Zojer
Recently, several advances have been made in understanding the pathogenesis of multiple myeloma. Increasing evidence favours a pre-switched, but somatically mutated B-cell as myeloma stem cell to give rise to the malignant clone. Deletions of the p53-gene, partial or total loss of chromosome 13 and rearrangements of band 14q32 and 11q13 are frequently found in multiple myeloma, and were shown to harbour prognostic significance. Presence or absence of distinct chromosomal aberrations may guide selection of treatment strategies in the future...
1999: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/8798281/evolution-of-multiple-myeloma-treatment-from-melphalan-monotherapy-to-bone-marrow-transplantation
#4
REVIEW
R Hájek, Z Adam, I Vásová, Z Král
Melphalan has brought the first improvement in the therapy of multiple myeloma at the beginning of the sixties. The median of survival was prolonged from several months to 3 years. In the following 3 decades new drugs were tested, but no other drug brought better results than melphalan. The comparative studies have proved, that therapy response has been reached more rapidly after polychemotherapy than after monotherapy, but none of the treatment modalities differed in the survival parameters. The significance of interferon alpha for the treatment of multiple myeloma has been tested since the beginning of the eighties...
1996: Acta Medica Austriaca
https://www.readbyqxmd.com/read/8693716/-treatment-of-multiple-myeloma-melphalan-monotherapy-after-bone-marrow-transplantation
#5
REVIEW
R Hájek, Z Adam, M Krejcí, I Vásová, Z Král, J Vorlícek
Melphalan has brought the first improvement in the therapy of multiple myeloma at the beginning of the sixties. The median of survival was prolonged from several months to three years. In the following three decades new drugs were tested, but no other drug brought better results than melphalan. The comparative studies have proved, that therapy response has been reached more rapidly after polychemotherapy than monotherapy, but none of the treatment modalities differed in the survival parameters. The significance of interferon alpha for the treatment of multiple myeloma has been tested since the beginning of the eighties...
April 1996: Vnitr̆ní Lékar̆ství
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