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https://www.readbyqxmd.com/read/29353447/the-combined-pn-stage-and-breast-cancer-subtypes-in-breast-cancer-a-better-discriminator-of-outcome-can-be-used-to-refine-the-8th-ajcc-staging-manual
#1
Zheng-Jun Yang, Yue Yu, Jiang-Rui Chi, Meng Guan, Ying Zhao, Xu-Chen Cao
BACKGROUND: pN stage and breast cancer subtypes (BCS) are both well-recognized prognostic indicators. Our previous work has highlighted that patients even with the same pN stage exhibited a significant survival difference in different BCS. Given this achievement, we hypothesized that a statistical interaction might exist between pN stage and BCS. The aim of this retrospective cohort study was to compare the prognostic value of the combined pN stage and BCS (pNnew stage) with either pN stage or BCS alone, and to determine if this combined new stage could serve as an alternative discriminator of outcome...
January 20, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29353396/the-differences-in-the-assessments-of-side-effects-at-an-oncology-outpatient-clinic
#2
A Bayraktar-Ekincioglu, E Kucuk
Background There is a growing interest in the use of targeted and immunotherapies in oncology. However, the assessment of side effects can be different due to interpretation of patients' health status by healthcare professionals in oncology outpatient clinics. Objective To demonstrate the differences in the assessments of side effects conducted independently by a clinical pharmacist and nurses in patients who receive targeted therapies at an oncology outpatient clinic. Setting The study was conducted at the University Oncology Hospital in an outpatient clinic from October 2015 to March 2016...
January 20, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29353385/the-relative-importance-of-clinical-economic-patient-values-and-feasibility-criteria-in-cancer-drug-reimbursement-in-canada-a-revealed-preferences-analysis-of-recommendations-of-the-pan-canadian-oncology-drug-review-2011-2017
#3
Chris Skedgel, Dominika Wranik, Min Hu
BACKGROUND: Most Canadian provinces and territories rely on the pan-Canadian Oncology Drug Review (pCODR) to provide recommendations regarding public reimbursement of cancer drugs. The pCODR review process considers four dimensions of value-clinical benefit, economic evaluation, patient-based values and adoption feasibility-but they do not define weights for individual decision criteria or an acceptable threshold for any of the criteria. Given this implicit review process, it is of interest to understand which factors appear to carry the most weight in pCODR recommendations using a revealed preferences approach...
January 20, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29353153/productivity-losses-due-to-premature-mortality-from-cancer-in-brazil-russia-india-china-and-south-africa-brics-a-population-based-comparison
#4
Alison Pearce, Linda Sharp, Paul Hanly, Anton Barchuk, Freddie Bray, Marianna de Camargo Cancela, Prakash Gupta, Filip Meheus, You-Lin Qiao, Freddy Sitas, Shao-Ming Wang, Isabelle Soerjomataram
BACKGROUND: Over two-thirds of the world's cancer deaths occur in economically developing countries; however, the societal costs of cancer have rarely been assessed in these settings. Our aim was to estimate the value of productivity lost in 2012 due to cancer-related premature mortality in the major developing economies of Brazil, the Russian Federation, India, China and South Africa (BRICS). METHODS: We applied an incidence-based method using the human capital approach...
January 16, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29353152/tgf%C3%AE-c-509t-tgf%C3%AE-t869c-xrcc1-arg194trp-ikb%C3%AE-c642t-il4-c-590t-genetic-polymorphisms-combined-with-socio-economic-lifestyle-diet-factors-and-gastric-cancer-risk-a-case-control-study-in-south-indian-population
#5
Dhayalan Pavithra, Majumdar Gautam, Ranganathan Rama, Rajaraman Swaminathan, Gopisetty Gopal, Ayyalur Seshadri Ramakrishnan, Thangarajan Rajkumar
BACKGROUND: Gastric cancer is worldwide the third major cause of cancer related death. Risk factors for gastric cancer includes Helicobacter pylori infection, gastric ulcer, less hygienic condition, use of tobacco, alcohol consumption, use of salted, smoked food, genetic alterations etc. In order to identify the risk factors associated with gastric cancer in South Indian population a case-control study involving 200 proven gastric cancer cases and 400 controls was conducted. METHODS: A structured questionnaire was used to interview all the subjects who participated in our study...
January 17, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29352986/association-of-androgen-deprivation-therapy-and-thromboembolic-events-a-systematic-review-and-meta-analysis
#6
Kevin T Nead, Ninjin Boldbaatar, David D Yang, Sumi Sinha, Paul L Nguyen
OBJECTIVES: To investigate the association of androgen deprivation therapy (ADT) for prostate cancer with thromboembolic events. METHODS: PubMed, Web of Science, and Scopus were queried April 5, 2017 for systematic review. Additionally, The World Health Organization International Trials Registry Platform was queried June 23rd, 2017. Eligible studies reported thromboembolic events among individuals with prostate cancer exposed to ADT versus a lesser-exposed group...
January 15, 2018: Urology
https://www.readbyqxmd.com/read/29352642/lgals4-ceacam6-tspan8-and-col1a2-blood-markers-for-colorectal-cancer-validation-in-a-cohort-of-subjects-with-positive-fecal-immunochemical-test-result
#7
Maria Teresa Rodia, Rossella Solmi, Francesco Pasini, Elena Nardi, Gabriella Mattei, Giampaolo Ugolini, Luigi Ricciardiello, Pierluigi Strippoli, Rossella Miglio, Mattia Lauriola
BACKGROUND: A noninvasive blood test for the early detection of colorectal cancer (CRC) is highly required. We evaluated a panel of 4 mRNAs as putative markers of CRC. MATERIALS AND METHODS: We tested LGALS4, CEACAM6, TSPAN8, and COL1A2, referred to as the CELTiC panel, using quantitative reverse transcription polymerase chain reaction, on subjects with positive fecal immunochemical test (FIT) results and undergoing colonoscopy. Using a nonparametric test and multinomial logistic model, FIT-positive subjects were compared with CRC patients and healthy individuals...
December 12, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29352608/differences-in-lung-injury-after-imrt-or-proton-therapy-assessed-by-18fdg-pet-imaging
#8
Nadya Shusharina, Zhongxing Liao, Radhe Mohan, Amy Liu, Andrzej Niemierko, Noah Choi, Thomas Bortfeld
BACKGROUND AND PURPOSE: To compare lung injury among non-small cell lung cancer (NSCLC) patients treated with IMRT or proton therapy as revealed by 18F-FDG post-treatment uptake and to determine factors predictive for clinically symptomatic radiation pneumonitis. MATERIAL AND METHODS: For 83 patients treated with IMRT or proton therapy, planning CT and follow up 18F-FDG PET-CT were analyzed. Post-treatment PET-CT was aligned with planning CT to establish a voxel-to-voxel correspondence between PET and planning dose images...
January 15, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29351801/high-expression-of-tmem40-is-associated-with-the-malignant-behavior-and-tumorigenesis-in-bladder-cancer
#9
Zhen-Fei Zhang, Han-Rong Zhang, Qing-Yan Zhang, Shu-Yu Lai, Yu-Zhen Feng, Yi Zhou, Si-Rong Zheng, Rong Shi, Jue-Yu Zhou
BACKGROUND: Bladder cancer (BCa) is one of the most common cancers in the urinary system among the world. Previous studies suggested that TMEM40 expression level was significantly associated with clinicopathological parameters including histological grade, clinical stage and pT status of bladder cancer. However, the molecular mechanism of TMEM40 in BCa remains poorly understood. METHODS: Real-time quantitative RT-PCR (qRT-PCR) and western blot (WB) were used to examine the expression levels of TMEM40 in BCa tissues, paired non-cancer tissues and cell lines...
January 19, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29351761/selective-serotonin-reuptake-inhibitor-use-and-breast-cancer-survival-a-population-based-cohort-study
#10
John Busby, Ken Mills, Shu-Dong Zhang, Fabio Giuseppe Liberante, Chris R Cardwell
BACKGROUND: Nearly 50% of breast cancer patients suffer from depression or anxiety. Selective serotonin reuptake inhibitors (SSRIs), the first-line pharmacological treatment for depression, have been implicated in breast cancer development through increased prolactin levels and tamoxifen metabolism inhibition. Previous studies of breast cancer progression have focused on tamoxifen users, or have been limited by their small sample size and methodology. Therefore, we used UK population-based data to more robustly investigate the association between SSRI use and cancer-specific mortality...
January 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29351612/a-mutational-signature-associated-with-alcohol-consumption-and-prognostically-significantly-mutated-driver-genes-in-esophageal-squamous-cell-carcinoma
#11
X C Li, M Y Wang, M Yang, H J Dai, B F Zhang, W Wang, X L Chu, X Wang, H Zheng, R F Niu, W Zhang, K X Chen
Background: Esophageal squamous cell carcinoma (ESCC) is often diagnosed at an advanced and incurable stage. Information on driver genes and prognosticators in ESCC remains incomplete. The objective was to elucidate significantly mutated genes (SMGs), mutational signatures, and prognosticators in ESCC. Patients and Methods: Three MutSig algorithms (i.e. MutSigCV, MutSigCL and MutSigFN) and "20/20+" ratio-metric were employed to identify SMGs. Nonnegative matrix factorization was used to decipher mutational signatures...
January 16, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29351573/multicenter-french-harmonization-study-for-pd-l1-ihc-testing-in-non-small-cell-lung-cancer
#12
J Adam, N Le Stang, I Rouquette, A Cazes, C Badoual, H Pinot-Roussel, L Tixier, C Danel, F Damiola, D Damotte, F Penault-Llorca, S Lantuéjoul
Background: Various PD-L1 immunohistochemistry (IHC) assays have been developed and used in clinical trials in association with different drugs. In order to harmonize and make PD-L1 testing in non-small cell lung cancer (NSCLC) widely available, we conducted a multicenter study comparing PD-L1 standardized assays and laboratory-developed tests (LDT). Methods: IHC with five anti-PD-L1 monoclonal antibodies (28-8, 22C3, E1L3N, SP142 and SP263) was performed concomitantly on 41 NSCLC surgical specimens in 7 centers using Dako Autostainer Link 48 (3 centers), Leica Bond (2 centers) or Ventana BenchMark Ultra (2 centers), platforms...
January 16, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29350706/symptom-burden-and-self-advocacy-exploring-the-relationship-among-female-cancer-survivors%C3%A2
#13
Teresa L Hagan, Stephanie Gilbertson-White, Susan M Cohen, Jennifer S Temel, Joseph A Greer, Heidi S Donovan
BACKGROUND: Although patient self-advocacy is a critical component of patient-centered care, the association between symptom burden and self-
advocacy has received little attention. 
. OBJECTIVES: This analysis evaluates the degree to which self-advocacy is associated with symptom burden among women with a history of cancer. 
. METHODS: Participants completed online or paper questionnaires. Descriptive statistics and ordinary least squares regression models were used to analyze the association between the three dimensions of self-advocacy and two dimensions of symptom burden...
February 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29350495/the-current-landscape-of-3d-in-vitro-tumor-models-what-cancer-hallmarks-are-accessible-for-drug-discovery
#14
REVIEW
Darren Rodenhizer, Teresa Dean, Elisa D'Arcangelo, Alison P McGuigan
Cancer prognosis remains a lottery dependent on cancer type, disease stage at diagnosis, and personal genetics. While investment in research is at an all-time high, new drugs are more likely to fail in clinical trials today than in the 1970s. In this review, a summary of current survival statistics in North America is provided, followed by an overview of the modern drug discovery process, classes of models used throughout different stages, and challenges associated with drug development efficiency are highlighted...
January 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29350424/prevalence-of-high-grade-cervical-intraepithelial-neoplasia-in-women-with-persistent-high-risk-hpv-genotypes-and-negative-cytology
#15
M Macdonald, J Crossley, K Ellis, N Dudding, R Lyon, J H F Smith, J A Tidy, J E Palmer
INTRODUCTION: Primary HPV screening will be implemented into the English Cervical Screening Programme by 2019. Its impact upon women referred to colposcopy, with negative cytology but persistently positive high-risk HPV (hrHPV), remains unreported from UK Sentinel sites. HPV primary screening was introduced in Sheffield, UK in April 2013; this paper reports its impact on the service. METHODS: A retrospective cohort study was performed from June 2014 to July 2016 at the Jessop Wing Colposcopy Unit, Sheffield...
January 19, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29350312/genesurance-counseling-patient-perspectives
#16
Chelsea Wagner, Lauren Murphy, Jacqueline Harkenrider, Sandra Darilek, Eleazar Soto-Torres, Quinn Stein, Jennifer Hoskovec
Genetic counselors (GCs) have reported an increase in discussion of insurance-related, or "genesurance," topics during genetic counseling sessions. Despite increasing frequency, there have been no studies examining patient expectations of GCs in these discussions. This study aimed to explore patient expectations of GCs in these discussions, as well as examine factors that may impact expectations. A 38-item survey was administered prior to patients receiving prenatal or cancer genetic counseling at 11 clinic sites across UTHealth, Baylor College of Medicine, and Sanford Health, with 360 responses analyzed...
January 19, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29349933/patient-s-specific-integration-of-oar-doses-d2%C3%A2-cc-from-ebrt-and-3d-image-guided-brachytherapy-for-cervical-cancer
#17
Edgar Gelover, Cabel Katherine, Christopher Mart, Wenqing Sun, Yusung Kim
The objective of this study was to assess the recommended DVH parameter (e.g., D2 cc) addition method used for combining EBRT and HDR plans, against a reference dataset generated from an EQD2-based DVH addition method. A revised DVH parameter addition method using EBRT DVH parameters derived from each patient's plan was proposed and also compared with the reference dataset. Thirty-one biopsy-proven cervical cancer patients who received EBRT and HDR brachytherapy were retrospectively analyzed. A parametrial and/or paraaortic EBRT boost were clinically performed on 13 patients...
January 19, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29349669/positive-correlation-between-matrix-metalloproteinases-and-epithelial-to-mesenchymal-transition-and-its-association-with-clinical-outcome-in-bladder-cancer-patients
#18
R Singh, A Mandhani, V Agrawal, Minal Garg
Involvement of matrix metalloproteinases (MMPs) in the pathogenesis of urothelial carcinoma elects them to be sensitive marker for clinical and prognostic implications. MMPs regulate tumor growth and invasion by inducing epithelial-to-mesenchymal transition (EMT) which is characterized by the complex reprogramming of epithelial cells and ultimately bring about major changes in the structural organization of bladder urothelium. The present study has been undertaken to evaluate the clinical relevance of MMPs in two distinct types of bladder cancer disease...
January 18, 2018: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/29349510/uncertain-effect-of-preventative-shoulder-rehabilitation-for-patients-who-underwent-total-laryngectomy-with-neck-dissection
#19
Peixia Wu, Zhengrong Peng, Junyi Chen, Yan Hu
INTRODUCTION: Total laryngectomy (TL) with neck dissection (ND) is considered as crucial management for advanced-stage of laryngeal cancer. Shoulder dysfunction has long been recognized as a potential complication resulting from neck dissection. The aim of this study was to evaluate the effect of early prophylactic rehabilitation program in patients who underwent TL with ND. METHODS: A prospective, nonrandomized design was used. Seventy-six participants who underwent TL with ND were assigned into either an intervention or a control group...
January 18, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29348902/feasibility-and-outcome-of-primary-laparoscopic-cytoreductive-surgery-for-advanced-epithelial-ovarian-cancer-a-comparison-to-laparotomic-surgery-in-retrospective-cohorts
#20
Huamao Liang, Hongyan Guo, Chunyu Zhang, FuLi Zhu, Yu Wu, Kun Zhang, Hua Li, Jinsong Han
Objectives: To assess the feasibility and outcome of primary laparoscopic cytoreductive surgery on advanced epithelial ovarian cancer in comparison with conventional open surgery. Materials and Methods: Patients undergoing primary laparoscopic cytoreductive surgery (LCS) from March 2007 to December 2016 were matched to controls treated with laparotomic cytoreduction during the same period. Procedural data and outcomes were analyzed. Results: The LCS group (n = 64) and laparotomic group (n = 68) had similar age, BMI, stages, histologic type and grading...
December 22, 2017: Oncotarget
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