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Mortality hematologic cancer

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https://www.readbyqxmd.com/read/29688266/anti-infective-vaccination-strategies-in-patients-with-hematologic-malignancies-or-solid-tumors-guideline-of-the-infectious-diseases-working-party-agiho-of-the-german-society-for-hematology-and-medical-oncology-dgho
#1
C T Rieger, B Liss, S Mellinghoff, D Buchheidt, O A Cornely, G Egerer, W J Heinz, M Hentrich, G Maschmeyer, K Mayer, M Sandherr, G Silling, A Ullmann, M J G T Vehreschild, M von Lilienfeld-Toal, H H Wolf, N Lehners
Infectious complications are a significant cause of morbidity and mortality in patients with malignancies specifically when receiving anticancer treatments. Prevention of infection through vaccines is an important aspect of clinical care of cancer patients. Immunocompromising effects of the underlying disease as well as of antineoplastic therapies need to be considered when devising vaccination strategies. This guideline provides clinical recommendations on vaccine use in cancer patients including autologous stem cell transplant recipients, while allogeneic stem cell transplantation is subject of a separate guideline...
April 24, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29668734/prognostic-value-of-hematological-parameters-in-patients-with-acute-myocardial-infarction-intrahospital-outcomes
#2
José Gildo de Moura Monteiro Júnior, Dilênia de Oliveira Cipriano Torres, Maria Cleide Freire Clementino da Silva, Cyntia Maria de Holanda Martins, Izadora Karina da Silva, Monique Evelyn Mendonça do Nascimento, Ana Célia Oliveira Dos Santos, Ulisses Ramos Montarroyos, Dário Celestino Sobral Filho
BACKGROUND: The intensity of the inflammatory response and hemodynamic repercussion in acute myocardial infarction causing the presence in the peripheral circulation of nucleated red blood cells (NRBCs), increases in mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) are associated with a poorer prognosis. The aim of this study was to assess the role of these hematological biomarkers as predictors of all causes of mortality during the hospitalization of patients with acute myocardial infarction...
2018: PloS One
https://www.readbyqxmd.com/read/29649549/bloodstream-infections-in-cancer-patients-risk-factors-associated-with-mortality
#3
Beda Islas-Muñoz, Patricia Volkow-Fernández, Cynthia Ibanes-Gutiérrez, Alberto Villamar-Ramírez, Diana Vilar-Compte, Patricia Cornejo-Juárez
OBJECTIVE: The aim of this study was to evaluate the clinical characteristics and risk factors associated with mortality in cancer patients with bloodstream infections (BSI), analyzing multidrug resistant bacteria (MDRB). METHODS: We conducted a prospective observational study at a cancer referral center from August 2016 to July 2017, which included all BSI. RESULTS: 4,220 patients were tested with blood cultures; 496 were included. Mean age was 48 years...
April 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29621990/risk-factors-for-long-term-mortality-in-patients-admitted-with-severe-infection
#4
J Francisco, I Aragão, T Cardoso
BACKGROUND: Severe infection is a main cause of mortality. We aim to describe risk factors for long-term mortality among inpatients with severe infection. METHODS: Prospective cohort study in a 600-bed university hospital in Portugal including all patients with severe infection admitted into intensive care, medical, surgical, hematology and nephrology wards over one-year period. The outcome of interest was 5-year mortality following infection. Variables of patient background and infectious episode were studied in association with the main outcome through multiple logistic regression...
April 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29621007/disseminated-intravascular-coagulation-is-it-fact-or-fancy
#5
Jae C Chang
: 'Disseminated intravascular coagulation (DIC)' occurs commonly in critical illnesses such as sepsis, trauma, cancer, and complications of surgery and pregnancy. Mortality is very high. The pathogenesis has been ascribed to tissue factor-initiated coagulation disorder, resulting in disseminated microblood clots that are made of platelets, plasma factors, fibrins, and blood cells. True DIC depletes coagulation factors and consumes platelets, and activates fibrinolysis. 'DIC' is assumed to orchestrate thrombocytopenia, microangiopathic hemolytic anemia and hypoxic multiorgan dysfunction syndrome, and causes hemorrhagic disorder due to depleted coagulation factors...
April 4, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29620191/arsenic-disulfide%C3%A2-induced-apoptosis-and-its-potential-mechanism-in-two%C3%A2-and-three%C3%A2-dimensionally-cultured-human-breast-cancer-mcf%C3%A2-7-cells
#6
Yuxue Zhao, Kenji Onda, Bo Yuan, Sachiko Tanaka, Anna Kiyomi, Kentaro Sugiyama, Munetoshi Sugiura, Norio Takagi, Toshihiko Hirano
In China, arsenic disulfide (As2S2) has been used for the treatment of hematological malignancies. The present study aimed to evaluate the effects of As2S2 on the human breast cancer MCF‑7 cell line cultured in both two‑dimensional (2D) monolayers and three‑dimensional (3D) spheroids to explore its therapeutic potential in breast cancer treatment. Cellular viability and the induction of apoptosis were examined with a cell counting kit‑8 (CCK‑8) assay and flow cytometric analysis, respectively. Alterations in the expression levels of apoptosis‑associated proteins, including Bcl‑2‑associated X protein (Bax), B‑cell lymphoma 2 (Bcl‑2), p53, and caspase‑7, as well as the cell survival‑associated proteins, phosphatidylinositol 3‑kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR), were assessed by western blotting...
April 4, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29617053/efficacy-and-safety-of-rivaroxaban-compared-to-enoxaparin-in-treatment-of-cancer-associated-venous-thromboembolism
#7
Benjamin Simmons, Waldemar Wysokinski, Rayya A Saadiq, Dalene Bott-Kitslaar, Stanislav Henkin, Ana Casanegra, Charles Lenz, Paul Daniels, Haraldur Bjarnason, Emily Vargas, David Hodge, Sara J Holton, James R Cerhan, Charles Loprinzi, Robert McBane
BACKGROUND: Low molecular weight heparin (LMWH) is the guideline endorsed treatment for cancer associated venous thromboembolism (cVTE). Study objectives were to compare the efficacy and safety of rivaroxaban and enoxaparin in cVTE. METHODS: Using a cohort study design, consecutive patients with cVTE (3/1/2013-7/31/2016), enrolled in the Mayo Thrombophilia Clinic Direct Oral Anticoagulants Registry were compared to contemporary cancer patients receiving enoxaparin...
April 4, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29608111/profile-of-non-hematological-pediatric-tumors-a-clinicopathological-study-at-a-tertiary-health-care-centre
#8
Kashmi Sharma, Mehar Aziz, Nishat Afroz, Aaliya Ehsan
BACKGROUND: Tumors in pediatric age group are biologically different from tumors in adults and emerging as a significant contributor to morbidity/mortality in children. OBJECTIVES: This study evaluated the epidemiological profile of pediatric solid tumors in 0-18 years of age over a period of 5 years in a general hospital in India. RESULTS: A total of 510 cases of tumors were included, which accounted for 5.1% of the total tumor burden of the hospital...
April 2, 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29582210/in-hospital-and-day-120-survival-of-critically-ill-solid-cancer-patients-after-discharge-of-the-intensive-care-units-results-of-a-retrospective-multicenter-study-a-groupe-de-recherche-respiratoire-en-r%C3%A3-animation-en-onco-h%C3%A3-matologie-grrr-oh-study
#9
François Vincent, Marcio Soares, Djamel Mokart, Virginie Lemiale, Fabrice Bruneel, Marouane Boubaya, Frédéric Gonzalez, Yves Cohen, Elie Azoulay, Michaël Darmon
OBJECTIVES: To assess outcomes at hospital discharge and day-120 after intensive care unit (ICU) discharge among patients with solid cancer admitted to ICU and to identify characteristics associated with in-hospital and day-120 after ICU discharge mortalities. DESIGN: International, multicenter, retrospective study. SETTING: Five ICUs in France and Brazil, two located in cancer centers, two in university affiliated and one in general hospitals...
March 27, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29579884/prevalence-and-survival-of-cancer-after-pancreas-kidney-transplantation
#10
M V Pendón-Ruiz de Mier, M L Agüera, M D Navarro, A Rodriguez-Benot, P Aljama
BACKGROUND: Malignancy is an important cause of mortality in solid organ transplantation. There have been few studies of de novo solid organ malignancy (NSOM) after pancreas-kidney transplantation (PKT). The aim of this study was analyze the prevalence of NSOM and transplant outcomes. METHODS: We studied the development of NSOM after PKT in our center from May 1990 to February 2017. We analyzed demographic characteristics, prevalence of cancer, and survival after cancer diagnosis...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29555313/a-comparison-of-the-myeloablative-conditioning-regimen-fludarabine-busulfan-with-cyclophosphamide-total-body-irradiation-for-allogeneic-stem-cell-transplantation-in-the-modern-era-a-cohort-analysis
#11
Mahasweta Gooptu, Haesook T Kim, Vincent T Ho, Edwin P Alyea, John Koreth, Philippe Armand, Jerome Ritz, Sarah Nikiforow, Brett E Glotzbecker, Prashant Nageshwar, Robert J Soiffer, Joseph H Antin, Corey S Cutler
INTRODUCTION: With improvement in transplantation practices in the modern era, non-relapse mortality (NRM) following allogeneic hematopoietic stem cell transplantation (HSCT) has improved, while disease relapse rates have remained unchanged. Survival outcomes are therefore driven by NRM in the modern era. Myeloablative conditioning (MAC) regimens are used to maximize disease control and facilitate engraftment; however their use is often limited by toxicity. The commonly used MAC regimens incorporate either chemotherapy plus total body irradiation (TBI) or combination chemotherapy...
March 16, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29551235/oncological-patients-admitted-to-an-intensive-care-unit-analysis-of-predictors-of-in-hospital-mortality
#12
D Díaz-Díaz, M Villanova Martínez, E Palencia Herrejón
OBJECTIVE: To analyze the factors influencing in-hospital mortality among cancer patients admitted to an Intensive Care Unit (ICU). DESIGN: A retrospective observational study was carried out. SETTING: The ICU of a community hospital. PATIENTS: Adults diagnosed with solid or hematological malignancies admitted to the ICU, excluding those admitted after scheduled surgery and those with an ICU stay of under 24h. INTERVENTIONS: Review of clinical data...
March 15, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29531285/defining-cure-in-multiple-myeloma-a-comparative-study-of-outcomes-of-young-individuals-with-myeloma-and-curable-hematologic-malignancies
#13
Praful Ravi, Shaji K Kumar, James R Cerhan, Matthew J Maurer, David Dingli, Stephen M Ansell, S Vincent Rajkumar
Advances in therapy in recent years have led investigators to challenge the dogma that multiple myeloma (MM) is incurable. We assessed overall (OS) and progression-free survival (PFS) of young patients ( ≤ 50 years) with MM and compared outcomes with follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and Hodgkin lymphoma (HL). All patients ≤ 50 years with newly diagnosed MM (n = 212), FL (n = 168), DLBCL (n = 195), and HL (n = 233) between 1 January 2005 and 31 December 2015 were included...
February 28, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29485154/embryonic-exposure-to-an-aqueous-coal-dust-extract-results-in-gene-expression-alterations-associated-with-the-development-and-function-of-connective-tissue-and-the-hematological-system-immunological-and-inflammatory-disease-and-cancer-in-zebrafish
#14
Karina Caballero-Gallardo, Sara E Wirbisky-Hershberger, Jesus Olivero-Verbel, Jesus de la Rosa, Jennifer L Freeman
Coal mining is one of the economic activities with the greatest impact on environmental quality. At all stages contaminants are released as particulates such as coal dust. The first aim of this study was to obtain an aqueous coal dust extract and characterize its composition in terms of trace elements by ICP-MS. In addition, the developmental toxicity of the aqueous coal extract was evaluated using zebrafish (Danio rerio) after exposure to different concentrations (0-1000 ppm; μg mL-1 ) to establish acute toxicity, morphology and transcriptome changes...
February 27, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29483708/an-off-the-shelf-fratricide-resistant-car-t-for-the-treatment-of-t-cell-hematologic-malignancies
#15
Matthew L Cooper, Jaebok Choi, Karl Staser, Julie K Ritchey, Jessica M Devenport, Kayla Eckardt, Michael P Rettig, Bing Wang, Linda G Eissenberg, Armin Ghobadi, Leah N Gehrs, Julie L Prior, Samuel Achilefu, Christopher A Miller, Catrina C Fronick, Julie O'Neal, Feng Gao, David M Weinstock, Alejandro Gutierrez, Robert S Fulton, John F DiPersio
T cell malignancies represent a group of hematologic cancers with high rates of relapse and mortality in patients for whom no effective targeted therapies exist. The shared expression of target antigens between chimeric antigen receptor (CAR) T cells and malignant T cells has limited the development of CAR-T because of unintended CAR-T fratricide and an inability to harvest sufficient autologous T cells. Here, we describe a fratricide-resistant "off-the-shelf" CAR-T (or UCART7) that targets CD7+ T cell malignancies and, through CRISPR/Cas9 gene editing, lacks both CD7 and T cell receptor alpha chain (TRAC) expression...
February 20, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29467672/serum-iron-levels-decreased-in-patients-with-hbv-related-hepatocellular-carcinoma-as-a-risk-factor-for-the-prognosis-of-hbv-related-hcc
#16
Yanyan Wei, Wei Ye, Wei Zhao
Background: Hepatocellular carcinoma (HCC) is common and the second leading causes of cancer-related deaths. HCC usually occurs on the basis of chronic liver diseases. At present, the study of iron metabolism in chronic liver diseases was limited to chronic HCV infection, nonalcoholic fatty liver disease, and alcoholic liver disease. This study aimed to investigate the effect of serum iron levels on the progression of chronic HBV infection and the relationship with the prognosis of HBV-related HCC. Methods: A respective study involving 277 healthy individuals as controls (HC), 295 patients with chronic hepatitis B (CHB), 224 patients with HBV-related liver cirrhosis (HBV-related LC), and 586 patients with HBV- related HCC were enrolled in this study...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29449166/clinical-characteristics-and-treatment-outcomes-of-pulmonary-invasive-fungal-infection-among-adult-patients-with-hematological-malignancy-in-a-medical-centre-in-taiwan-2008-2013
#17
Chien-Yuan Chen, Wang-Huei Sheng, Feng-Ming Tien, Po-Chu Lee, Shang-Yi Huang, Jih-Luh Tang, Woei Tsay, Hwei-Fang Tien, Po-Ren Hsueh
BACKGROUND/PURPOSE: This study was aimed to investigate clinical characteristics and treatment outcomes of pulmonary invasive fungal infection (IFI) among patients with hematological malignancy. METHODS: All patients with hematological malignancy who were treated at a medical centre from 2008 to 2013 were evaluated. Pulmonary IFI was classified according to the European Organization for Research and Treatment of Cancer 2008 consensus. RESULTS: During the study period, 236 (11...
January 31, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29427174/adverse-effects-associated-with-clinical-applications-of-car-engineered-t-cells
#18
REVIEW
Zohreh Sadat Badieyan, Sayed Shahabuddin Hoseini
Cancer has been ranked as the second leading cause of death in the United States. To reduce cancer mortality, immunotherapy is gaining momentum among other therapeutic modalities, due to its impressive results in clinical trials. The genetically engineered T cells expressing chimeric antigen receptors (CARs) are emerging as a new approach in cancer immunotherapy, with the most successful outcomes in the refractory/relapse hematologic malignancies. However, the widespread clinical applications are limited by adverse effects some of which are life-threatening...
February 9, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29410023/histone-deacetylase-inhibitors-upregulate-snail-via-smad2-3-phosphorylation-and-stabilization-of-snail-to-promote-metastasis-of-hepatoma-cells
#19
Wei Xu, Hao Liu, Zhi-Gang Liu, Hong-Sheng Wang, Fan Zhang, Hao Wang, Ji Zhang, Jing-Jing Chen, Hong-Jun Huang, Yuan Tan, Meng-Ting Cao, Jun Du, Qiu-Gui Zhang, Guan-Min Jiang
Hepatocellular carcinoma (HCC) remains the third most common cause of cancer-related mortality. Resection and transplantation are the only curative treatments available, but are greatly hampered by high recurrence rates. Histone deacetylase inhibitors (HDACIs) are considered to be promising anticancer agents in drug development. Currently, four HDACIs have been granted Food and Drug Administration (FDA) approval for cancer. HDACIs have shown significant efficacy in hematological malignancies. However, they have limited effects in epithelial cell-derived cancers, including HCC, and the mechanisms of these are not elucidated...
January 30, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29395053/clonal-hematopoiesis-and-evolution-to-hematopoietic-malignancies
#20
REVIEW
Robert L Bowman, Lambert Busque, Ross L Levine
Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood cells with one or more somatic mutations. Individuals with CH are at greater risk for hematological malignancies, cardiovascular disease, and increased mortality from non-hematological cancers. Understanding the causes of CH and how these mutant cells interact with cells of other tissues will provide critical insights into preleukemic development, stem cell biology, host-immune interactions, and cancer evolution. Here we discuss the clinical manifestations of CH, mechanisms contributing to its development, the role of CH in clonal evolution toward leukemia, and the contribution of CH to non-hematological disease states...
February 1, 2018: Cell Stem Cell
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