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https://www.readbyqxmd.com/read/27903157/obesity-and-other-cancers
#1
Lin Yang, Bettina F Drake, Graham A Colditz
Purpose Evidence on overweight, obesity, and an increased risk of cancer continues to accumulate and was updated in the 2016 handbook on weight control from the International Agency for Research on Cancer (IARC). The underlying primary data, together with dose-response meta-analysis and, finally, pooled analysis of individual participant data, add insight into the relation between obesity and cancer risk and prognosis. We summarize the evidence for mortality from prostate cancer, hematologic malignancies, and kidney cancer...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27888116/hpv16-induces-a-wasting-syndrome-in-transgenic-mice-amelioration-by-dietary-polyphenols-via-nf-%C3%AE%C2%BAb-inhibition
#2
Rui M Gil da Costa, Sofia Aragão, Magda Moutinho, Antonieta Alvarado, Diogo Carmo, Fátima Casaca, Sandra Silva, Joana Ribeiro, Hugo Sousa, Rita Ferreira, Rita Nogueira-Ferreira, Maria João Pires, Bruno Colaço, Carlos Venâncio, Maria Manuel Oliveira, Margarida M S M Bastos, Carlos Lopes, Paula A Oliveira
Cancer patients often show a wasting syndrome for which there are little therapeutic options. Dietary polyphenols have been proposed for treating this syndrome, but their usefulness in cases associated with human papillomavirus (HPV)-induced cancers is unknown. We characterized HPV16-transgenic mice as a model of cancer cachexia and tested the efficacy of long-term oral supplementation with polyphenols curcumin and rutin. Both compounds were orally administered to six weeks-old HPV16-transgenic mice showing characteristic multi-step skin carcinogenesis, for 24weeks...
November 22, 2016: Life Sciences
https://www.readbyqxmd.com/read/27877037/acute-and-subacute-toxicity-profiles-of-thymoquinone-loaded-nanostructured-lipid-carrier-in-balb-c-mice
#3
Yong Sze Ong, Latifah Saiful Yazan, Wei Keat Ng, Mustapha M Noordin, Sarah Sapuan, Jhi Biau Foo, Yin Sim Tor
BACKGROUND: Thymoquinone (TQ), the predominant active lipophilic component in Nigella sativa seed oil, has a variety of pharmacological properties such as anticancer activities. However, translation of TQ to clinical phase is still not possible due to its hydrophobic properties. This problem can be solved by encapsulating it in nanoformulations to enhance its pharmacological properties. In our previous study, TQ has been successfully encapsulated in a nanostructured lipid carrier (hereinafter referred to as TQNLC) with excellent physiochemical properties such as high encapsulation efficiency, high drug-loading capacity, particle diameter less than 100 nm, and stability up to 2 years...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27876589/usa-hospitalizations-for-malignant-pleural-effusions-data-from-the-2012-national-inpatient-sample
#4
Niloofar Taghizadeh, Marc Fortin, Alain Tremblay
BACKGROUND: Malignant pleural effusions (MPE) are a common complication of advanced malignancy, but little is known regarding their prevalence and overall burden on a population level. METHODS: We conducted a retrospective analysis of MPE associated hospitalizations using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample, Agency for Healthcare Research and Quality (HCUP-NIS 2012). Cases were included if MPE was coded as a primary or secondary diagnosis or if an unspecified pleural effusion was coded in addition to a diagnosis of cancer with either of these being the primary diagnosis...
November 19, 2016: Chest
https://www.readbyqxmd.com/read/27870568/morbidity-and-mortality-differences-between-hematopoietic-cell-transplantation-survivors-and-other-cancer-survivors
#5
Eric J Chow, Kara L Cushing-Haugen, Guang-Shing Cheng, Michael Boeckh, Nandita Khera, Stephanie J Lee, Wendy M Leisenring, Paul J Martin, Beth A Mueller, Stephen M Schwartz, K Scott Baker
Purpose To compare the risks of serious health outcomes among hematopoietic cell transplantation (HCT) survivors versus a matched population of patients with cancer who did not undergo HCT, where the primary difference may be exposure to HCT. Methods Two-year HCT survivors treated at a comprehensive cancer center from 1992 through 2009 who were Washington State residents (n = 1,792; 52% allogeneic and 90% hematologic malignancies) were frequency matched by demographic characteristics and underlying cancer diagnosis (as applicable) to non-HCT 2-year cancer survivors, using the state cancer registry (n = 5,455) and the general population (n = 16,340) using driver's license files...
November 21, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27843210/an-audit-of-early-complications-of-radical-cystectomy-using-clavien-dindo-classification
#6
Nitesh Patidar, Priyank Yadav, Sanjoy Kumar Sureka, Varun Mittal, Rakesh Kapoor, Anil Mandhani
INTRODUCTION: Despite the major improvements in surgical technique and perioperative care, radical cystectomy (RC) remains a major operative procedure with a significant morbidity and mortality. The present study analyzes the early complications of RC and urinary diversion using a standardized reporting system. MATERIALS AND METHODS: Modified Clavien-Dindo classification was used to retrospectively assess the peri-operative course of 212 patients who had RC with urinary diversion between October 2003 and October 2014 at a single institution...
October 2016: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/27837506/serological-approaches
#7
Barbora Weinbergerova, Iva Kocmanova, Zdenek Racil, Jiri Mayer
The diagnosis of invasive fungal diseases (IFD) based on clinical, radiological, and conventional microbiological findings is not reliable and is often delayed. Non-culture-based methods with higher sensitivity and specificity may reduce diagnostic time and result in decreased IFD morbidity and mortality. These methods are now increasingly used to manage patients at risk of IFD. Among available biomarkers, fungal antigens have been investigated as an aid to early diagnosis and are predominantly used as screening tests to prompt antifungal treatment mainly in patients with hematological malignancies...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27834937/improved-survival-for-patients-diagnosed-with-chronic-lymphocytic-leukemia-in-the-era-of-chemo-immunotherapy-a-danish-population-based-study-of-10455-patients
#8
C da Cunha-Bang, J Simonsen, K Rostgaard, C Geisler, H Hjalgrim, C U Niemann
The treatment of chronic lymphocytic leukemia (CLL) is in rapid transition, and during recent decades both combination chemotherapy and immunotherapy have been introduced. To evaluate the effects of this development, we identified all CLL patients registered in the nation-wide Danish Cancer Register between 1978 and 2013. We identified 10 455 CLL patients and 508 995 CLL-free control persons from the general population. Compared with the latter, the relative mortality rate between CLL patients and their controls decreased from 3...
November 11, 2016: Blood Cancer Journal
https://www.readbyqxmd.com/read/27815226/utility-of-the-serum-galactomannan-assay-for-the-diagnosis-of-invasive-aspergillosis-in-children-with-acute-lymphoblastic-leukemia
#9
Gulhadiye Avcu, Deniz Yilmaz Karapinar, Ayse Burcu Akinci, Zuhal Onder Sivis, Akkiz Sahin, Zumrut Sahbudak Bal, Suleyha Hilmioglu Polat, Dilek Yesim Metin, Fadil Vardar, Yesim Aydinok
OBJECTIVES: Invasive aspergillosis (IA) is an important cause of mortality and morbidity in children with hematological malignancies. The monitoring of serum galactomannan (GM) antigen is considered useful in the diagnosis of IA . The aim of this study was to determine the utility of serum GM monitoring in the early diagnosis of IA and the role of positive antigenemia in the management of children with acute lymphoblastic leukemia (ALL). METHODS: The cases of 141 children who were being treated for ALL in the Division of Pediatric Hematology of the Medical School of Ege University between January 2006 and February 2015 were reviewed retrospectively...
November 1, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27784742/allogeneic-stem-cell-transplantation-a-historical-and-scientific-overview
#10
REVIEW
Anurag K Singh, Joseph P McGuirk
The field of hematopoietic stem cell transplant (HSCT) has made ground-breaking progress in the treatment of many malignant and nonmalignant conditions. It has also pioneered the concepts of stem cell therapy and immunotherapy as a tool against cancer. The success of transplant for hematologic malignancies derives both from the ability to treat patients with intensive chemoradiotherapy and from potent graft-versus-leukemia (GVL) effects mediated by donor immunity. Additionally, HSCT has been a curative therapy for several nonmalignant hematologic disorders through the provision of donor-derived hematopoiesis and immunity...
October 26, 2016: Cancer Research
https://www.readbyqxmd.com/read/27777768/jak2-v617f-mutation-multiple-hematologic-and-non-hematologic-processes-an-association
#11
Kenneth G Liu, Amit Verma, Olga Derman, Noah Kornblum, Murali Janakiram, Ira Braunschweig, Ramakrishna Battini
BACKGROUND: Population studies showed that patients with JAK2 V617F mutation had increased mortality, and increased risk of any cancer, hematologic cancer, and myeloproliferative disease. CASE PRESENTATION: A 68-year-old Asian male with JAK2 V617F mutation developed four different hematologic and non-hematologic neoplastic processes. In 2009, he was diagnosed with stage IA lung adenocarcinoma and also noted to have worsening leukocytosis and thrombocytosis with peak platelet count of 1,054,000/mL)...
2016: Biomarker Research
https://www.readbyqxmd.com/read/27737963/long-term-single-institute-experience-with-trimodal-bladder-preserving-therapy-with-proton-beam-therapy-for-muscle-invasive-bladder-cancer
#12
Ei-Ichiro Takaoka, Jun Miyazaki, Hitoshi Ishikawa, Koji Kawai, Tomokazu Kimura, Ryutaro Ishitsuka, Takahiro Kojima, Reiko Kanuma, Daichi Takizawa, Toshiyuki Okumura, Hideyuki Sakurai, Hiroyuki Nishiyama
OBJECTIVE: We retrospectively elucidated the oncological outcomes, prognostic factors and toxicities of proton beam therapy in trimodal bladder-preserving therapy for muscle-invasive bladder cancer at our institution. METHODS: From 1990 to 2015, 70 patients with cT2-3N0M0 muscle-invasive bladder cancer underwent trimodal bladder-preserving therapy consisting of maximal transurethral resection of the bladder tumor, small pelvis photon irradiation, intra-arterial chemotherapy and proton beam therapy...
October 13, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27710851/cancer-mortality-among-adolescents-and-young-adults-a-historical-cohort-in-a-reference-institution-for-cancer-treatment-in-santa-catarina-south-of-brazil-2002-2013
#13
Lizana Arend Henrique, Isabela de Carlos Back
OBJECTIVE: To identify factors associated with early mortality from cancer in adolescents and young adults in a reference institution for oncology treatment in Santa Catarina, Brazil. METHODS: We studied a retrospective cohort with an intentional sample of adolescents (ages 15-19) and young adults (ages 20-29) diagnosed with neoplasia. Secondary data were acquired from January 2002 to December 2013. Kaplan-Meier and Cox regression methods were used for survival analysis...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27699030/chemotherapy-induced-fatal-hepatitis-b-virus-reactivation-in-a-small-cell-lung-cancer-patient
#14
Lei Qin, Fang Wang, Bing-Wen Zou, Zhen-Yu Ding
Hepatitis B virus (HBV) reactivation during chemotherapy is a major concern and is widely reported, particularly in association with hematological malignancies and lymphomas. While lung cancer ranks first in incidence and mortality worldwide, HBV reactivation has been largely overlooked in this disease. As regards small-cell lung cancer (SCLC), HBV reactivation has rarely been reported. We herein report the case of a hepatitis B surface antigen-seropositive SCLC patient in whom HBV was reactivated during the course of chemotherapy, despite preemptive use of lamivudine...
October 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27650839/team-cognition-as-a-means-to-improve-care-delivery-in-critically-ill-patients-with-cancer-after-hematopoietic-cell-transplantation
#15
Nathan J McNeese, Nandita Khera, Sara E Wordingham, Noel Arring, Sharon Nyquist, Amy Gentry, Brian Tomlinson, Nancy J Cooke, Ayan Sen
Hematopoietic cell transplantation (HCT) is an important and complex treatment modality for a variety of hematologic malignancies and some solid tumors. Although outcomes of patients who have undergone HCT and require care in intensive care units (ICUs) have improved over time, mortality rates remain high and there are significant associated costs. Lack of a team-based approach to care, especially during critical illness, is detrimental to patient autonomy and satisfaction, and to team morale, ultimately leading to poor quality of care...
September 20, 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27633880/cytoreductive-surgery-plus-hyperthermic-intraperitoneal-chemotherapy-with-lobaplatin-and-docetaxel-improves-survival-for-patients-with-peritoneal-carcinomatosis-from-abdominal-and-pelvic-malignancies
#16
Hai-Tao Wu, Xiao-Jun Yang, Chao-Qun Huang, Jian-Hua Sun, Zhong-He Ji, Kai-Wen Peng, Qian Zhang, Yan Li
BACKGROUND: This work was to evaluate the perioperative safety and efficacy of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) with lobaplatin and docetaxel in patients with peritoneal carcinomatosis (PC) from gastrointestinal and gynecological cancers. METHODS: Patients were treated by CRS + HIPEC with lobaplatin 50 mg/m(2) and docetaxel 60 mg/m(2) in 6000 mL of normal saline at 43 ± 0.5 °C for 60 min. Vital signs were recorded for 6 days after CRS + HIPEC procedures...
September 15, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27621244/menopausal-hormone-therapy-in-cancer-survivors-a-narrative-review-of-the-literature
#17
REVIEW
Carol L Kuhle, Ekta Kapoor, Richa Sood, Jacqueline M Thielen, Aminah Jatoi, Stephanie S Faubion
Decision making regarding the use of menopausal hormone therapy (MHT) for the treatment of bothersome menopausal symptoms in a cancer survivor can be complex, and includes assessment of its impact on disease-free or overall survival. Estrogen receptors are present in several cancer types, but this does not always result in estrogen-mediated tumor proliferation and adverse cancer-related outcomes. Estrogen may even be protective against certain cancers. Menopausal hormone therapy is associated with an increased risk of recurrence and mortality after diagnosis of some cancer types, but not others...
October 2016: Maturitas
https://www.readbyqxmd.com/read/27581780/candidemia-in-cancer-patients-focus-mainly-on-hematological-malignancyand-hematopoietic-stem-cell-transplantation
#18
Keiji Okinaka
Although many new antifungals have become commercially available since 2000, candidemia remains an important public health issue because of its poor prognosis. Some studies have suggested that early antifungal therapy is associated with decreased mortality; however, it is difficult to promptly diagnose candidemia because of the poor sensitivity of blood cultures. Thus, prophylaxis against Candida infection is recommended in patient groups in whom the risk of infection is high, such as allogeneic hematopoietic stem cell transplant recipients or those undergoing intensive remission-induction chemotherapy for acute leukemia...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27575937/clostridium-tertium-in-neutropenic-patients-case-series-at-a-cancer-institute
#19
Sweta Shah, Jennifer Hankenson, Smitha Pabbathi, John Greene, Sowmya Nanjappa
OBJECTIVE: Clostridium tertium is considered an uncommon pathogen in humans, but is a cause of bacteremia in patients with underlying hematological malignancies and neutropenia. A case series highlighting 10 years of experience with C. tertium as a cause of bacteremia in this population is presented; the cases were seen at a National Cancer Institute designated cancer center. METHODS: Institutional review board approval was obtained prior to the start of the study...
August 26, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27570854/prevalence-and-risk-factors-of-gram-negative-bacilli-causing-blood-stream-infection-in-patients-with-malignancy
#20
Fawzia E Al-Otaibi, Elham E Bukhari, Mona Badr, Abdulkarim A Alrabiaa
OBJECTIVES: To evaluate the epidemiology, risk factors, and antibiotic resistance of Gram negative bacteria (GNB) in patients with hematologic or solid organ malignancies.   METHODS: This is a retrospective study of 61 episodes of GNB bacteremia occurring in 56 patients with malignancy admitted to the Oncology Units in King Khalid University Hospital, Riyadh. Kingdom of Saudi Arabia during the period from January 2013 to October 2015. Data were retrieved from the computerized database of the microbiology laboratory and the patient's medical records...
September 2016: Saudi Medical Journal
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