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RSV and oxygen saturation

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https://www.readbyqxmd.com/read/26336601/vitamin-d-levels-are-unrelated-to-the-severity-of-respiratory-syncytial-virus-bronchiolitis-among-hospitalized-infants
#1
Avraham Beigelman, Mario Castro, Toni L Schweiger, Brad S Wilson, Jie Zheng, Huiquing Yin-DeClue, Geneline Sajol, Tusar Giri, Oscar L Sierra, Megan Isaacson-Schmid, Kaharu Sumino, Kenneth B Schechtman, Leonard B Bacharier
BACKGROUND: Vitamin D deficiency at birth has been reported as a risk factor for respiratory syncytial virus (RSV) lower respiratory tract infection during the first year of life. Limited data are available on whether an infant's vitamin D status is associated with the severity of acute RSV bronchiolitis. METHODS: Infants < 1 year of age and hospitalized with their first episode of RSV bronchiolitis were enrolled into the RSV Bronchiolitis in Early Life II cohort...
September 2015: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/26249835/alcohol-during-pregnancy-worsens-acute-respiratory-infections-in-children
#2
MULTICENTER STUDY
Romina Libster, Fausto M Ferolla, Diego R Hijano, Patricio L Acosta, Anabella Erviti, Fernando P Polack
AIM: This study explored whether alcohol consumption during pregnancy increased the risk of life-threatening respiratory infections in children. METHODS: We prospectively evaluated children under the age of two years admitted to hospitals in Buenos Aires, Argentina, with severe acute respiratory infections during the winters of 2011 and 2012. Information on maternal alcohol consumption during the third trimester of pregnancy was collected using standardised questionnaires and categorised as never, low if it was once a week and high if it was equal or more than once a week...
November 2015: Acta Paediatrica
https://www.readbyqxmd.com/read/25879805/severe-acute-respiratory-infection-in-children-in-a-densely-populated-urban-slum-in-kenya-2007-2011
#3
Robert F Breiman, Leonard Cosmas, M Njenga, John Williamson, Joshua A Mott, Mark A Katz, Dean D Erdman, Eileen Schneider, M Oberste, John C Neatherlin, Henry Njuguna, Daniel M Ondari, Kennedy Odero, George O Okoth, Beatrice Olack, Newton Wamola, Joel M Montgomery, Barry S Fields, Daniel R Feikin
BACKGROUND: Reducing acute respiratory infection burden in children in Africa remains a major priority and challenge. We analyzed data from population-based infectious disease surveillance for severe acute respiratory illness (SARI) among children <5 years of age in Kibera, a densely populated urban slum in Nairobi, Kenya. METHODS: Surveillance was conducted among a monthly mean of 5,874 (range = 5,778-6,411) children <5 years old in two contiguous villages in Kibera...
2015: BMC Infectious Diseases
https://www.readbyqxmd.com/read/25783105/severe-acute-respiratory-infection-in-children-in-a-densely-populated-urban-slum-in-kenya-2007-2011
#4
Robert F Breiman, Leonard Cosmas, M Kariuki Njenga, John Williamson, Joshua A Mott, Mark A Katz, Dean D Erdman, Eileen Schneider, M Steven Oberste, John C Neatherlin, Henry Njuguna, Daniel M Ondari, Kennedy Odero, George O Okoth, Beatrice Olack, Newton Wamola, Joel M Montgomery, Barry S Fields, Daniel R Feikin
BACKGROUND: Reducing acute respiratory infection burden in children in Africa remains a major priority and challenge. We analyzed data from population-based infectious disease surveillance for severe acute respiratory illness (SARI) among children <5 years of age in Kibera, a densely populated urban slum in Nairobi, Kenya. METHODS: Surveillance was conducted among a monthly mean of 5,874 (range = 5,778-6,411) children <5 years old in two contiguous villages in Kibera...
December 2015: BMC Infectious Diseases
https://www.readbyqxmd.com/read/25773054/leukotriene-inhibitors-for-bronchiolitis-in-infants-and-young-children
#5
REVIEW
Fang Liu, Jing Ouyang, Atul N Sharma, Songqing Liu, Bo Yang, Wei Xiong, Rufu Xu
BACKGROUND: Bronchiolitis is an acute inflammatory illness of the bronchioles common among infants and young children. It is often caused by the respiratory syncytial virus (RSV). Management of bronchiolitis varies between clinicians, reflecting the lack of evidence for a specific treatment approach. The leukotriene pathway has been reported to be involved in the pathogenesis of bronchiolitis. Leukotriene inhibitors such as montelukast have been used in infants and young children with bronchiolitis...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25436452/resveratrol-enhances-palmitate-induced-er-stress-and-apoptosis-in-cancer-cells
#6
Cristina Rojas, Belén Pan-Castillo, Cristina Valls, Gerard Pujadas, Santi Garcia-Vallve, Lluis Arola, Miquel Mulero
BACKGROUND: Palmitate, a saturated fatty acid (FA), is known to induce toxicity and cell death in various types of cells. Resveratrol (RSV) is able to prevent pathogenesis and/or decelerate the progression of a variety of diseases. Several in vitro and in vivo studies have also shown a protective effect of RSV on fat accumulation induced by FAs. Additionally, endoplasmic reticulum (ER) stress has recently been linked to cellular adipogenic responses. To address the hypothesis that the RSV effect on excessive fat accumulation promoted by elevated saturated FAs could be partially mediated by a reduction of ER stress, we studied the RSV action on experimentally induced ER stress using palmitate in several cancer cell lines...
2014: PloS One
https://www.readbyqxmd.com/read/25344148/inter-society-consensus-document-on-treatment-and-prevention-of-bronchiolitis-in-newborns-and-infants
#7
Eugenio Baraldi, Marcello Lanari, Paolo Manzoni, Giovanni A Rossi, Silvia Vandini, Alessandro Rimini, Costantino Romagnoli, Pierluigi Colonna, Andrea Biondi, Paolo Biban, Giampietro Chiamenti, Roberto Bernardini, Marina Picca, Marco Cappa, Giuseppe Magazzù, Carlo Catassi, Antonio Francesco Urbino, Luigi Memo, Gianpaolo Donzelli, Carlo Minetti, Francesco Paravati, Giuseppe Di Mauro, Filippo Festini, Susanna Esposito, Giovanni Corsello
Acute bronchiolitis is the leading cause of lower respiratory tract infection and hospitalization in children less than 1 year of age worldwide. It is usually a mild disease, but some children may develop severe symptoms, requiring hospital admission and ventilatory support in the ICU. Infants with pre-existing risk factors (prematurity, bronchopulmonary dysplasia, congenital heart diseases and immunodeficiency) may be predisposed to a severe form of the disease. Clinical diagnosis of bronchiolitis is manly based on medical history and physical examination (rhinorrhea, cough, crackles, wheezing and signs of respiratory distress)...
2014: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/25300167/antibiotics-for-bronchiolitis-in-children-under-two-years-of-age
#8
REVIEW
Rebecca Farley, Geoffrey K P Spurling, Lars Eriksson, Chris B Del Mar
BACKGROUND: Bronchiolitis is a serious, potentially life-threatening respiratory illness commonly affecting babies. It is often caused by respiratory syncytial virus (RSV). Antibiotics are not recommended for bronchiolitis unless there is concern about complications such as secondary bacterial pneumonia or respiratory failure. Nevertheless, they are often used. OBJECTIVES: To evaluate the effectiveness of antibiotics for bronchiolitis in children under two years of age compared to placebo or other interventions...
October 9, 2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24862359/infants-under-6-months-with-bronchiolitis-are-most-likely-to-need-major-medical-interventions-in-the-5-days-after-onset
#9
H Pruikkonen, M Uhari, T Dunder, T Pokka, M Renko
AIM: This study examined the need for, and timing of, major medical interventions (MMIs) in infants under 6 months of age with bronchiolitis. METHODS: We reviewed the medical records of 353 children who visited our emergency department with bronchiolitis. MMI was defined as the need for any of the following interventions during admission: supplementary oxygen, intravenous fluids, intravenous antibiotics or admission to the intensive care unit. RESULTS: Altogether 19% of the 353 patients required a MMI and 3% had apnoea...
October 2014: Acta Paediatrica
https://www.readbyqxmd.com/read/24606114/viral-aetiology-and-clinical-outcomes-in-hospitalised-infants-presenting-with-respiratory-distress
#10
Kathy Falkenstein-Hagander, Ann-Sofie Månsson, Johan Redmo, Percy Nilsson Wimar, Anders Widell
AIM: To determine the prevalence of various types of viruses in infants hospitalised due to respiratory distress, compare molecular diagnostic tests and evaluate symptom severity. METHODS: All 136 nasopharyngeal aspirates from infants hospitalised for respiratory distress over a 9-month period were analysed for virus type by in-house respiratory syncytial virus (RSV) polymerase chain reaction (PCR) microarray-based and/or Luminex-based multiplex molecular tests...
June 2014: Acta Paediatrica
https://www.readbyqxmd.com/read/24374757/predicting-the-severity-of-acute-bronchiolitis-in-infants-should-we-use-a-clinical-score-or-a-biomarker
#11
Flore Amat, Cécile Henquell, Matthieu Verdan, Laurence Roszyk, Aurélien Mulliez, André Labbé
Krebs von den Lungen 6 antigen (KL-6) has been shown to be a useful biomarker of the severity of Respiratory syncytial virus bronchiolitis. To assess the correlation between the clinical severity of acute bronchiolitis, serum KL-6, and the causative viruses, 222 infants with acute bronchiolitis presenting at the Pediatric Emergency Department of Estaing University Hospital, Clermont-Ferrand, France, were prospectively enrolled from October 2011 to May 2012. Disease severity was assessed with a score calculated from oxygen saturation, respiratory rate, and respiratory effort...
November 2014: Journal of Medical Virology
https://www.readbyqxmd.com/read/23602048/-food-intake-during-the-previous-24h-as-a-percentage-of-usual-intake-a-marker-of-hypoxia-in-infants-with-bronchiolitis-an-observational-prospective-multicenter-study
#12
MULTICENTER STUDY
F Corrard, F de La Rocque, E Martin, C Wollner, A Elbez, M Koskas, A Wollner, R Cohen
BACKGROUND: Hypoxia associated with bronchiolitis is not always easy to assess on clinical grounds alone. The aim of this study was to determine the value of food intake during the previous 24h (bottle and spoon feeding), as a percentage of usual intake (24h FI), as a marker of hypoxia, and to compare its diagnostic value with that of usual clinical signs. METHODS: In this observational, prospective, multicenter study, 18 community pediatricians, enrolled 171 infants, aged from 0 to 6 months, with bronchiolitis (rhinorrhea+dyspnea+cough+expiratory sounds)...
June 2013: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/23311899/food-intake-during-the-previous-24-h-as-a-percentage-of-usual-intake-a-marker-of-hypoxia-in-infants-with-bronchiolitis-an-observational-prospective-multicenter-study
#13
MULTICENTER STUDY
François Corrard, France de La Rocque, Elvira Martin, Claudie Wollner, Annie Elbez, Marc Koskas, Alain Wollner, Michel Boucherat, Robert Cohen
BACKGROUND: Hypoxia associated with bronchiolitis is not always easy to assess on clinical grounds alone. The aim of this study was to determine the value of food intake during the previous 24 hours (bottle and spoon feeding), as a percentage of usual intake (24h FI), as a marker of hypoxia, and to compare its diagnostic value with that of usual clinical signs. METHODS: In this observational, prospective, multicenter study, 18 community pediatricians, enrolled 171 infants, aged from 0 to 6 months, with bronchiolitis (rhinorrhea + dyspnea + cough + expiratory sounds)...
January 11, 2013: BMC Pediatrics
https://www.readbyqxmd.com/read/22937071/etiology-and-incidence-of-viral-and-bacterial-acute-respiratory-illness-among-older-children-and-adults-in-rural-western-kenya-2007-2010
#14
Daniel R Feikin, M Kariuki Njenga, Godfrey Bigogo, Barrack Aura, George Aol, Allan Audi, Geoffrey Jagero, Peter Ochieng Muluare, Stella Gikunju, Leonard Nderitu, Amanda Balish, Jonas Winchell, Eileen Schneider, Dean Erdman, M Steven Oberste, Mark A Katz, Robert F Breiman
BACKGROUND: Few comprehensive data exist on disease incidence for specific etiologies of acute respiratory illness (ARI) in older children and adults in Africa. METHODOLOGY/PRINCIPAL FINDINGS: From March 1, 2007, to February 28, 2010, among a surveillance population of 21,420 persons >5 years old in rural western Kenya, we collected blood for culture and malaria smears, nasopharyngeal and oropharyngeal swabs for quantitative real-time PCR for ten viruses and three atypical bacteria, and urine for pneumococcal antigen testing on outpatients and inpatients meeting a ARI case definition (cough or difficulty breathing or chest pain and temperature >38...
2012: PloS One
https://www.readbyqxmd.com/read/22914561/viral-and-bacterial-causes-of-severe-acute-respiratory-illness-among-children-aged-less-than-5-years-in-a-high-malaria-prevalence-area-of-western-kenya-2007-2010
#15
Daniel R Feikin, M Kariuki Njenga, Godfrey Bigogo, Barrack Aura, George Aol, Allan Audi, Geoffrey Jagero, Peter O Muluare, Stella Gikunju, Leonard Nderitu, Jonas M Winchell, Eileen Schneider, Dean D Erdman, M Steven Oberste, Mark A Katz, Robert F Breiman
BACKGROUND: Few comprehensive data exist on the etiology of severe acute respiratory illness (SARI) among African children. METHODS: From March 1, 2007 to February 28, 2010, we collected blood for culture and nasopharyngeal and oropharyngeal swabs for real-time quantitative polymerase chain reaction for 10 viruses and 3 atypical bacteria among children aged <5 years with SARI, defined as World Health Organization-classified severe or very severe pneumonia or oxygen saturation <90%, who visited a clinic in rural western Kenya...
January 2013: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/22389988/emergency-room-management-of-acute-bronchiolitis-a-randomized-trial-of-nebulized-epinephrine
#16
RANDOMIZED CONTROLLED TRIAL
Pelin Ozlem Simşek-Kiper, Nural Kiper, Gülşen Hasçelik, Anil Dolgun, Ebru Yalçin, Deniz Doğru-Ersöz, Uğur Ozçelik
Acute bronchiolitis is a common, potentially life-threatening condition with few therapeutic options. In the present randomized study, we compared the clinical efficacies of nebulized epinephrine and salbutamol in the emergency room management of acute bronchiolitis. Primary outcome measures were improvement in mean respiratory rate, mean oxygen saturation value and severity score. Secondary outcome measures were length of hospital stay, hospitalization and relapse rates. A total of 75 patients were analyzed (36 epinephrine, 39 salbutamol)...
November 2011: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/22185352/reduced-inflammation-and-altered-innate-response-in-neonates-during-paramyxoviral-infection
#17
Somashubhra Bhattacharya, Brandon T Beal, Ann M Janowski, Laurie P Shornick
BACKGROUND: Human infants are frequently hospitalized due to infection with the paramyxovirus respiratory syncytial virus (RSV). However, very little is known about the neonatal response to paramyxoviral infection. Here, a neonatal model of paramyxoviral infection is developed using the mouse pathogen Sendai virus (SeV). RESULTS: Adult mice infected with SeV developed a predominantly neutrophilic inflammatory cell influx and a concomitant reduction in lung function, as determined by oxygen saturation...
2011: Virology Journal
https://www.readbyqxmd.com/read/21927808/chest-physiotherapy-using-passive-expiratory-techniques-does-not-reduce-bronchiolitis-severity-a-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Isabelle Rochat, Patricia Leis, Marie Bouchardy, Christine Oberli, Hendrika Sourial, Margrit Friedli-Burri, Thomas Perneger, Constance Barazzone Argiroffo
Chest physiotherapy (CP) using passive expiratory manoeuvres is widely used in Western Europe for the treatment of bronchiolitis, despite lacking evidence for its efficacy. We undertook an open randomised trial to evaluate the effectiveness of CP in infants hospitalised for bronchiolitis by comparing the time to clinical stability, the daily improvement of a severity score and the occurrence of complications between patients with and without CP. Children <1 year admitted for bronchiolitis in a tertiary hospital during two consecutive respiratory syncytial virus seasons were randomised to group 1 with CP (prolonged slow expiratory technique, slow accelerated expiratory flow, rarely induced cough) or group 2 without CP...
March 2012: European Journal of Pediatrics
https://www.readbyqxmd.com/read/21683109/attenuated-interleukin-8-leukocyte-immunoresponse-in-preterm-infants-compared-with-term-infants-hospitalized-with-respiratory-syncytial-virus-bronchiolitis-a-pilot-study
#19
COMPARATIVE STUDY
Dagnachew Assefa, Nikhil Amin, Allen J Dozor, Lance A Parton
Decreased transplacental transfer of antibodies and altered immunoresponsiveness may place preterm (PT) infants at higher risk for serious consequences from respiratory syncytial virus (RSV) bronchiolitis. We hypothesize that among infants hospitalized with RSV bronchiolitis, immune response in PT infants may be different when compared with that of term infants. Nasal-wash samples were collected from 11 PT (<37 weeks of gestation) and 13 term infants (≥37 weeks of gestation) hospitalized with RSV bronchiolitis...
September 2011: Human Immunology
https://www.readbyqxmd.com/read/21678346/antibiotics-for-bronchiolitis-in-children
#20
REVIEW
Geoffrey Kp Spurling, Jenny Doust, Chris B Del Mar, Lars Eriksson
BACKGROUND: Bronchiolitis is a serious, potentially life-threatening respiratory illness commonly affecting babies. It is often caused by respiratory syncytial virus (RSV). Antibiotics are not recommended for bronchiolitis unless there is concern about complications such as secondary bacterial pneumonia or respiratory failure. Nevertheless, they are used at rates of 34% to 99% in uncomplicated cases. OBJECTIVES: To evaluate the effectiveness of antibiotics for bronchiolitis...
2011: Cochrane Database of Systematic Reviews
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