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wint/beta signaling

Mary Beth Genter, Kathleen H Goss, Joanna Groden
Chloracetanilide herbicides are multisite carcinogens in rodents. Progression of alachlor-induced olfactory tumors in rats is accompanied by cytoplasmic accumulation and nuclear localization of beta-catenin, suggesting activation of Wint signaling. Female CD-1 mice were resistant to alachlor-induced olfactory carcinogenesis. The current studies were performed to determine whether Apc(Min/+) mice, which have activated Wnt signaling due to mutation of the second allele of Apc, would be susceptible to alachlor olfactory carcinogenesis...
November 2004: Toxicologic Pathology
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