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Attention deficit disorder pregnancy

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https://www.readbyqxmd.com/read/29127207/perinatal-outcomes-after-treatment-with-adhd-medication-during-pregnancy
#1
Ulrika Nörby, Birger Winbladh, Karin Källén
OBJECTIVES: To analyze perinatal outcomes after maternal use of attention-deficit/hyperactivity disorder (ADHD) medication during pregnancy. METHODS: The study included singletons born between 2006 and 2014 in Sweden. Data on prescription drug use, pregnancies, deliveries, and the newborn infants' health were obtained from the Swedish Medical Birth Register, the Prescribed Drug Register, and the Swedish Neonatal Quality Register. We compared infants exposed to ADHD medication during pregnancy with infants whose mothers never used these drugs and infants whose mothers used ADHD medication before or after pregnancy...
November 10, 2017: Pediatrics
https://www.readbyqxmd.com/read/29112657/placental-complications-associated-with-psychostimulant-use-in-pregnancy
#2
Jacqueline M Cohen, Sonia Hernández-Díaz, Brian T Bateman, Yoonyoung Park, Rishi J Desai, Kathryn J Gray, Elisabetta Patorno, Helen Mogun, Krista F Huybrechts
OBJECTIVE: To evaluate whether psychostimulants used to treat attention-deficit/hyperactivity disorder (ADHD) are associated with risk of adverse placental-associated pregnancy outcomes including preeclampsia, placental abruption, growth restriction, and preterm birth. METHODS: We designed a population-based cohort study in which we examined a cohort of pregnant women and their liveborn neonates enrolled in Medicaid from 2000 to 2010. Women who received amphetamine-dextroamphetamine or methylphenidate monotherapy in the first half of pregnancy were compared with unexposed women...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29100171/the-danger-of-being-inattentive%C3%A2-%C3%A2-adhd-symptoms-and-risky-sexual-behaviour-in-russian-adolescents
#3
J Isaksson, A Stickley, R Koposov, V Ruchkin
BACKGROUND: Prior research has indicated that attention-deficit/hyperactivity disorder (ADHD) symptoms may be associated with an increased likelihood of engaging in risky sexual behaviour (RSB). However, research on this association among adolescents has been comparatively limited and mainly confined to North America. The aim of this study was to examine if inattention and hyperactivity/impulsivity symptoms were linked to RSB in a community cohort sample of Russian adolescents. METHODS: The study was based on a group of 537 adolescents from Northern Russia...
September 28, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29063614/meta-analyses-of-externalizing-disorders-genetics-or-prenatal-alcohol-exposure
#4
Leah Wetherill, Tatiana Foroud, Charles Goodlett
BACKGROUND: Externalizing disorders are heritable precursors to alcohol dependence, common in children of alcoholics (COA), and in children with prenatal alcohol exposure (PAE). Pregnancies involving alcohol exposure sufficient to affect the fetus may involve women with genetic risk for alcohol dependence (AD). We hypothesized that known PAE will increase the odds of having an externalizing disorder compared to COA. METHODS: The odds ratios of three externalizing disorders [attention deficit hyperactivity (ADHD), conduct disorder (CD), and oppositional defiant disorder (ODD)] were obtained for two domains: (1) PAE and (2) COA, by estimating the logged odds ratios (LOR) for each study...
October 23, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28987706/combined-effects-of-prenatal-exposure-to-polycyclic-aromatic-hydrocarbons-and-material-hardship-on-child-adhd-behavior-problems
#5
Frederica P Perera, Kylie Wheelock, Ya Wang, Deliang Tang, Amy E Margolis, Gladys Badia, Whitney Cowell, Rachel L Miller, Virginia Rauh, Shuang Wang, Julie B Herbstman
IMPORTANCE: Polycyclic aromatic hydrocarbons (PAH) are carcinogenic and neurotoxic combustion by-products commonly found in urban air. Exposure to PAH is disproportionately high in low income communities of color who also experience chronic economic stress. OBJECTIVE: In a prospective cohort study in New York City (NYC) we previously found a significant association between prenatal PAH exposure and Attention Deficit Hyperactivity Disorder (ADHD) behavior problems at age 9...
October 4, 2017: Environmental Research
https://www.readbyqxmd.com/read/28982961/mechanisms-in-endocrinology-maternal-thyroid-dysfunction-during-pregnancy-and-behavioural-and-psychiatric-disorders-of-children-a-systematic-review
#6
REVIEW
Dagnachew Muluye Fetene, Kim S Betts, Rosa Alati
BACKGROUND: Maternal thyroid dysfunction during pregnancy may lead to persistent neurodevelopmental disorders in the offspring appearing in later life. This study aimed to review the available evidence concerning the relationship between maternal thyroid status during pregnancy and offspring behavioural and psychiatric disorders. METHODS: Systematic electronic database searches were conducted using PubMed, Embase, PsycNET, Scopus, Google Scholar and Cochrane library...
November 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28982838/hypertensive-disorders-of-pregnancy-and-risk-of-neurodevelopmental-disorders-in-the-offspring-a-systematic-review-and-meta-analysis-protocol
#7
Gillian M Maher, Gerard W O'Keeffe, Louise C Kenny, Patricia M Kearney, Ted G Dinan, Ali S Khashan
INTRODUCTION: Hypertensive disorders of pregnancy (HDPs), that is chronic hypertension, gestational hypertension, pre-eclampsia (de novo or superimposed on chronic hypertension) and white coat hypertension, affect approximately 5%-15% of pregnancies. HDP exposure has been linked to an increased risk of autism spectrum disorder, attention deficit/hyperactivity disorder and other neurodevelopmental disorders in children. However, findings are inconsistent, and a clear consensus on the impact of HDPs on the risk of neurodevelopmental disorders is needed...
October 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28982350/pilot-study-indicate-role-of-preferentially-transmitted-monoamine-oxidase-gene-variants-in-behavioral-problems-of-male-adhd-probands
#8
Arijit Karmakar, Rishov Goswami, Tanusree Saha, Subhamita Maitra, Anirban Roychowdhury, Chinmay Kumar Panda, Swagata Sinha, Anirban Ray, Kochupurackal P Mohanakumar, Usha Rajamma, Kanchan Mukhopadhyay
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is an etiologically complex childhood onset neurobehavioral disorder characterized by age-inappropriate inattention, hyperactivity, and impulsivity. Symptom severity varies widely and boys are diagnosed more frequently than girls. ADHD probands were reported to have abnormal transmissions of dopamine, serotonin, and/or noradrenaline. Monoamine oxidase A (MAOA) and B (MAOB), mitochondrial outer membrane bound two isoenzymes, mediate degradation of these neurotransmitters and thus regulating their circulating levels...
October 5, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28947451/use-of-glucocorticoids-during-pregnancy-and-risk-of-attention-deficit-hyperactivity-disorder-in-offspring-a-nationwide-danish-cohort-study
#9
Kristina Laugesen, Anna Byrjalsen, Trine Frøslev, Morten S Olsen, Henrik Toft Sørensen
OBJECTIVE: Prenatal exposure to excess endogenous glucocorticoid (GC) has been linked to attention-deficit/hyperactivity disorder (ADHD). We investigated whether prenatal exposure to exogenous GC is associated with ADHD. DESIGN: Nationwide cohort study. SETTING: A cohort of 875 996 singletons born alive between 1996 and 2009 in Denmark. Data were obtained from national registries. EXPOSURES: We identified children exposed prenatally to GCs, children unexposed prenatally and born to maternal former users, and children unexposed and born to maternal never users...
September 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28734254/childhood-polybrominated-diphenyl-ether-pbde-exposure-and-neurobehavior-in-children-at-8-years
#10
Ann M Vuong, Kimberly Yolton, Changchun Xie, Glenys M Webster, Andreas Sjödin, Joseph M Braun, Kim N Dietrich, Bruce P Lanphear, Aimin Chen
BACKGROUND: Prenatal polybrominated diphenyl ether (PBDE) exposure has been associated with decrements in IQ and increased attention deficit/hyperactivity disorder related behaviors in children; however, data are limited for the role of postnatal exposures. OBJECTIVES: We investigated the association between a series of childhood PBDE concentrations and Full-Scale Intelligence Quotient (FSIQ) and externalizing problems at 8 years. METHODS: We used data from 208 children in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort...
October 2017: Environmental Research
https://www.readbyqxmd.com/read/28729328/comparative-safety-of-antiepileptic-drugs-for-neurological-development-in-children-exposed-during-pregnancy-and-breast-feeding-a-systematic-review-and-network-meta-analysis
#11
Areti Angeliki Veroniki, Patricia Rios, Elise Cogo, Sharon E Straus, Yaron Finkelstein, Ryan Kealey, Emily Reynen, Charlene Soobiah, Kednapa Thavorn, Brian Hutton, Brenda R Hemmelgarn, Fatemeh Yazdi, Jennifer D'Souza, Heather MacDonald, Andrea C Tricco
OBJECTIVES: Compare the safety of antiepileptic drugs (AEDs) on neurodevelopment of infants/children exposed in utero or during breast feeding. DESIGN AND SETTING: Systematic review and Bayesian random-effects network meta-analysis (NMA). MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched until 27 April 2017. Screening, data abstraction and quality appraisal were completed in duplicate by independent reviewers. PARTICIPANTS: 29 cohort studies including 5100 infants/children...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28728761/predictors-of-co-occurring-neurodevelopmental-disabilities-in-children-with-autism-spectrum-disorders
#12
Lauren Head Zauche, Ashley E Darcy Mahoney, Melinda K Higgins
PURPOSE: Co-occurring neurodevelopmental disabilities (including cognitive and language delays and attention deficit hyperactivity disorder) affect over half of children with ASD and may affect later behavioral, language, and cognitive outcomes beyond the ASD diagnosis. However, no studies have examined predictors of co-occurring neurodevelopmental disabilities in children with ASD. This study investigated whether maternal sociodemographic, perinatal and neonatal factors are associated with co-occurring disabilities...
July 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28712019/maternal-body-mass-index-before-pregnancy-as-a-risk-factor-for-adhd-and-autism-in-children
#13
Christina Hebsgaard Andersen, Per Hove Thomsen, Ellen Aagaard Nohr, Sanne Lemcke
The risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) may be influenced by environmental factors such as maternal obesity before pregnancy. Previous studies investigating those associations have found divergent results. We aim to investigate in a large birth cohort this association further in children with ADHD, ASD and comorbid ADHD and ASD. Our study population consisted of 81,892 mother-child pairs participating in the Danish National Birth Cohort (DNBC). Information about pre-pregnancy weight and height was collected in week 16 of pregnancy; the analysis was divided into groups based on BMI...
July 15, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28685401/high-maternal-vitamin-d-levels-in-early-pregnancy-may-protect-against-behavioral-difficulties-at-preschool-age-the-rhea-mother-child-cohort-crete-greece
#14
Vasiliki Daraki, Theano Roumeliotaki, Katerina Koutra, Georgia Chalkiadaki, Marianna Katrinaki, Andriani Kyriklaki, Mariza Kampouri, Katerina Margetaki, Marina Vafeiadi, Stathis Papavasiliou, Manolis Kogevinas, Leda Chatzi
Animal studies suggest that prenatal vitamin D status may affect fetal brain growth. However, human studies are scarce with conflicting results. We aimed to investigate the association of maternal 25-hydroxyvitamin D [25(OH) D] levels with multiple neurodevelopmental outcomes at 4 years of age. We included 487 mother-child pairs from the prospective pregnancy cohort, "Rhea" in Crete, Greece. Maternal serum 25(OH) D concentrations were measured at the first prenatal visit (13 ± 2.4 weeks). Cognitive functions at 4 years were assessed by means of the McCarthy Scales of Children's Abilities...
July 6, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28664541/placebo-response-and-its-determinants-in-children-with-adhd-across-multiple-observers-and-settings-a-randomized-clinical-trial
#15
Weam Fageera, Alexandru Traicu, Sarojini M Sengupta, Marie-Eve Fortier, Zia Choudhry, Aurélie Labbe, Natalie Grizenko, Ridha Joober
This study aims to quantify placebo response (PR) in children with attention deficit hyperactivity disorder (ADHD) as assessed by parents and teachers and to explore some of its determinants. Five hundred and forty children with ADHD (ages 6-12) were recruited to a randomized, double-blind, placebo-controlled crossover trial with methylphenidate. The main outcome variable was Conners' Global Index (CGI), based on assessment of behaviour by parents (CGI-P) and teacher (CGI-T). PR was calculated as the difference between CGI-P/T scores at baseline and placebo week...
June 30, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28664227/within-family-effects-of-smoking-during-pregnancy-on-adhd-the-importance-of-phenotype
#16
Kristine Marceau, L Cinnamon Bidwell, Hollis C Karoly, Allison Schettini Evans, Alexandre A Todorov, Rohan H Palmer, Andrew C Heath, Valerie S Knopik
We sought to test within- and between- family associations of smoking during pregnancy (SDP) and attention deficit-hyperactivity disorder (ADHD) symptoms using a structured interview based on the conventional Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) symptoms and the Strengths and Weaknesses of ADHD-Symptoms and Normal-Behavior (SWAN) scale, which is a population based measure that grew out of the notion that an ADHD diagnosis exists on the extreme end of a continuum of normative behaviors and includes both above- and below- average performance on attention and activity...
June 30, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28662467/locus-specific-dna-methylation-changes-and-phenotypic-variability-in-children-with-attention-deficit-hyperactivity-disorder
#17
Sarojini M Sengupta, Alicia K Smith, Natalie Grizenko, Ridha Joober
Maternal smoking during pregnancy is the most commonly cited risk factor for ADHD. While the causal relation between this factor and ADHD is debated, several lines of evidence suggest that it modulates the severity of ADHD, particularly through higher association with conduct disorder (CD). We hypothesized that maternal smoking during pregnancy may be associated with differential methylation in selected genes in children with ADHD. DNA extracted from peripheral blood was used to examine methylation between 25 children exposed, and 22 children not exposed to maternal smoking during pregnancy...
June 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28661961/in-utero-exposure-to-antihypertensive-medication-and-neonatal-and-child-health-outcomes-a-systematic-review
#18
Catherine A Fitton, Markus F C Steiner, Lorna Aucott, Jill P Pell, Daniel F Mackay, Michael Fleming, James S McLay
BACKGROUND: Although medication is generally avoided wherever possible during pregnancy, pharmacotherapy is required for the treatment of pregnancy associated hypertension, which remains a leading cause of maternal and fetal morbidity and mortality. The long-term effects to the child of in-utero exposure to antihypertensive agents remains largely unknown. OBJECTIVE: The aim of this study was to systematically review published studies on adverse outcomes to the child associated with in-utero exposure to antihypertensive medications...
November 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28645698/radiological-studies-of-fetal-alcohol-spectrum-disorders-in-humans-and-animal-models-an-updated-comprehensive-review
#19
REVIEW
Van T Nguyen, Suyinn Chong, Quang M Tieng, Karine Mardon, Graham J Galloway, Nyoman D Kurniawan
Fetal Alcohol Spectrum Disorders encompass a wide range of birth defects in children born to mothers who consumed alcohol during pregnancy. Typical mental impairments in FASD include difficulties in life adaptation and learning and memory, deficits in attention, visuospatial skills, language and speech disabilities, mood disorders and motor disabilities. Multimodal imaging methods have enabled in vivo studies of the teratogenic effects of alcohol on the central nervous system, giving more insight into the FASD phenotype...
November 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28640459/antidepressant-use-in-pregnancy-and-the-risk-of-attention-deficit-with-or-without-hyperactivity-disorder-in-children
#20
Takoua Boukhris, Odile Sheehy, Anick Bérard
BACKGROUND: The association between antidepressant (AD) use during pregnancy and the risk of attention deficit with or without hyperactivity disorder (ADHD) in children is debated. We investigated the risk of ADHD associated with overall and class-specific antidepressant exposure in utero. METHODS: We designed a register-based cohort study using the Quebec Pregnancy/Children Cohort (QPC). A total of 144 406 singleton full-term live-born from 1998 to 2009 were included...
July 2017: Paediatric and Perinatal Epidemiology
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