keyword
https://read.qxmd.com/read/38314597/severe-acro-osteolysis-mimicking-arthritis-mutilans-in-a-patient-with-primary-hyperparathyroidism-a-case-report
#1
Tanya Sapundzhieva, Lyubomir Sapundzhiev, Kamen Klinkanov, Martin Mitev, Anastas Batalov
BACKGROUND: Primary hyperparathyroidism (PHPT) should be considered in the differential diagnosis of a patient with suspected secondary osteoporosis, and severe osteoporosis with multiple fractures is frequently the first clinical manifestation of the disease. CASE PRESENTATION: Mutilating arthritis (arthritis mutilans) can be part of the clinical presentation of a number of rheumatic diseases, most commonly seen in psoriatic arthritis, rheumatoid arthritis, and juvenile idiopathic arthritis, but also in systemic lupus, systemic sclerosis, and multicentric reticulohistiocytosis...
January 2, 2024: Current Rheumatology Reviews
https://read.qxmd.com/read/38006373/papa-syndrome-challenges-in-achieving-long-term-remission
#2
JOURNAL ARTICLE
Hana Smajlović, Asja Prohić
For over two decades, the acronym PAPA syndrome has been used to describe an autoinflammatory condition caused by missense mutations in the PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1) gene and clinically characterized by the presence of pyogenic arthritis, pyoderma gangrenosum (PG), and acne (1,2). Due to the involvement of the PSTPIP1 gene in the regulation of innate immunity, mutations of this gene cause abnormal activation of inflammasomes, complexes of NLRP3/ASC/caspase-1 proteins...
November 2023: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/37144266/clinical-characteristics-and-treatment-outcomes-of-children-with-primary-osteoporosis
#3
JOURNAL ARTICLE
Sirmen Kızılcan Çetin, Zeynep Şıklar, Zehra Aycan, Elif Özsu, Ayşegül Ceran, Gizem Şenyazar, Seda Erişen Karaca, Merih Berberoğlu
OBJECTIVE: Primary osteoporosis is a rare and essential problem in childhood that can cause severe skeletal deformities. We aimed to reveal the spectrum of primary osteoporosis and assess the effectiveness and safety of bisphosphonates in increasing bone mineral density and reducing fractures. MATERIALS AND METHODS: Patients with primary osteoporosis who received at least one course of pamidronate or zoledronic acid were included in the study. Patients were divided into 2 groups, osteogenesis imperfecta and non-osteogenesis imperfecta subjects...
May 2023: Turkish archives of pediatrics
https://read.qxmd.com/read/36217542/safety-and-efficacy-of-probiotic-supplementation-in-8-types-of-inflammatory-arthritis-a-systematic-review-and-meta-analysis-of-34-randomized-controlled-trials
#4
Liuting Zeng, Ying Deng, Qi He, Kailin Yang, Jun Li, Wang Xiang, Huiping Liu, Xiaofei Zhu, Hua Chen
OBJECTIVE: To evaluate Safety and efficacy of probiotic supplementation in inflammatory arthritis. METHODS: The literature on the treatment of inflammatory arthritis with probiotics has been collected in databases such as CNKI, Pubmed, Cochrane library, Embase, etc. The search time is for them to build the database until May 2022. The included literatures are randomized controlled trials (RCTs) of probiotics in the treatment of hyperuricemia and gout. The Cochrane risk assessment tool was used for quality evaluation, and the Rev Man5...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36213368/foot-and-ankle-conventional-radiography-in-juvenile-idiopathic-arthritis-does-it-still-matter
#5
JOURNAL ARTICLE
Magdalena Posadzy, Anna Sowińska, Filip Vanhoenacker, Piotr Gietka, Ewa Żelnio, Iwona Sudoł-Szopińska
Objectives: The aim of this study was to evaluate the residual value of Conventional Radiography in children with arthralgia clinically suspected of Juvenile Idiopathic Arthritis (JIA). Materials and Methods: Three hundred seventy-two patients aged 1-18 years suspected of JIA were retrospectively reviewed. All patients had foot and ankle plain films performed in standard two projections: ankle in antero-posterior and lateral, and foot in antero-posterior and oblique...
2022: Journal of the Belgian Society of Radiology
https://read.qxmd.com/read/35628529/bone-health-in-children-with-rheumatic-disorders-focus-on-molecular-mechanisms-diagnosis-and-management
#6
REVIEW
Francesca Di Marcello, Giulia Di Donato, Debora Mariarita d'Angelo, Luciana Breda, Francesco Chiarelli
Bone is an extremely dynamic and adaptive tissue, whose metabolism and homeostasis is influenced by many different hormonal, mechanical, nutritional, immunological and pharmacological stimuli. Genetic factors significantly affect bone health, through their influence on bone cells function, cartilage quality, calcium and vitamin D homeostasis, sex hormone metabolism and pubertal timing. In addition, optimal nutrition and physical activity contribute to bone mass acquisition in the growing age. All these factors influence the attainment of peak bone mass, a critical determinant of bone health and fracture risk in adulthood...
May 20, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/34749805/progressive-pseudorheumatoid-dysplasia-misdiagnosed-as-juvenile-idiopathic-arthritis-a-case-report
#7
JOURNAL ARTICLE
Anjumanara Anver Omar, Salman Ahmed, John Chris Rodrigues, Allan Kayiza, Lawrence Owino
BACKGROUND: Progressive pseudorheumatoid dysplasia is a rare, autosomal recessively inherited, noninflammatory musculoskeletal disorder caused by mutations occurring in the WNT1-inducible signaling pathway protein 3 gene. Joint cartilage is the primary site of involvement, leading to arthralgia, joint stiffness, contractures, enlargement of the epiphyses and metaphysis of the hand joints, spinal abnormalities, short stature, early osteoarthritis, and osteoporosis. Juvenile idiopathic arthritis is the most common chronic rheumatic disease in childhood and has unknown etiology...
November 8, 2021: Journal of Medical Case Reports
https://read.qxmd.com/read/34341698/premature-senescence-of-t-cells-favors-bone-loss-during-osteolytic-diseases-a-new-concern-in-the-osteoimmunology-arena
#8
JOURNAL ARTICLE
Luis González-Osuna, Alfredo Sierra-Cristancho, Carolina Rojas, Emilio A Cafferata, Samanta Melgar-Rodríguez, Angélica M Cárdenas, Rolando Vernal
Cellular senescence is a biological process triggered in response to time-accumulated DNA damage, which prioritizes cell survival over cell function. Particularly, senescent T lymphocytes can be generated prematurely during chronic inflammatory diseases regardless of chronological aging. These senescent T lymphocytes are characterized by the loss of CD28 expression, a co-stimulatory receptor that mediates antigen presentation and effective T-cell activation. An increased number of premature senescent CD4+ CD28- T lymphocytes has been frequently observed in osteolytic diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, osteopenia, osteoporosis, and osteomyelitis...
August 2021: Aging and Disease
https://read.qxmd.com/read/34331423/idiopathic-juvenile-osteoporosis-in-a-child-a-four-year-follow-up-with-review-of-literature
#9
REVIEW
Aashima Dabas, Rakhi Malhotra, Ravindra Kumar, Rajesh Khadgawat
OBJECTIVES: Childhood osteoporosis is an uncommon condition that usually develops secondary to underlying disease states. Idiopathic juvenile osteoporosis or early onset osteoporosis is a rare cause of primary osteoporosis in childhood associated with mutations in "bone fragility" genes. CASE PRESENTATION: The index case presented with upper back pain and was detected to have multiple vertebral fractures. Further workup for the cause revealed a homozygous benign mutation in low-density lipoprotein receptor-related protein 5, which was also detected in the mother who remained asymptomatic till presentation...
November 25, 2021: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/34307793/multicentric-osteolysis-nodulosis-and-arthropathy-in-two-unrelated-children-with-matrix-metalloproteinase-2-variants-genetic-skeletal-correlations
#10
Hanan Elsebaie, Mohamed Abdelhafiz Mansour, Solaf M Elsayed, Shady Mahmoud, Tamer A El-Sobky
Multicentric Osteolysis, Nodulosis, and Arthropathy (MONA) syndrome is a rare genetic skeletal dysplasia. Its diagnosis can be deceptively similar to childhood-onset genetic skeletal dysplasias and juvenile idiopathic arthritis. We aimed to report the syndrome's clinical and radiologic features with emphasis on skeletal manifestations. And establish relevant phenotype-genotype correlations. We evaluated two boys, 4-and-7-years-old with MONA syndrome. Both patients had consanguineous parents. We verified the diagnosis by correlating the outcomes of clinical, radiologic and molecular analysis...
December 2021: Bone Reports
https://read.qxmd.com/read/34218632/efficacy-and-safety-of-intravenous-pamidronate-infusion-for-treating-osteoporosis-in-children-and-adolescents
#11
JOURNAL ARTICLE
Ji-Hee Yoon, Yunha Choi, Yena Lee, Han-Wook Yoo, Jin-Ho Choi
PURPOSE: Osteoporosis is a skeletal disorder characterized by reduced bone mass that results in increased risk of fractures. Pediatric osteoporosis can be caused by monogenic diseases, chronic diseases, and/or their treatment. This study was performed to investigate the effect of pamidronate infusion on osteoporosis in children and adolescents. METHODS: This study included 13 unrelated pediatric patients (10 males and 3 females) whose bone mineral density (BMD) z-score was <-2...
June 2021: Annals of Pediatric Endocrinology & Metabolism
https://read.qxmd.com/read/34040998/progressive-idiopathic-juvenile-osteoporosis-in-pregnancy-a-case-report-of-two-successive-pregnancies-in-the-same-woman
#12
Kaori Kishimoto, Chisato Kodera, Fumitaka Saito, Takashi Ohba, Hidetaka Katabuchi
A 33-year-old primiparous woman with progressive idiopathic juvenile osteoporosis (IJO) who had had multiple vertebral compressions and bilateral femoral neck fractures since the age of 15 years presented for perinatal management at 11 weeks of gestation. Her vertebral bone mass was 0.634 g/cm2 before pregnancy. The target calcium intake was set at 800 mg/day. Cephalopelvic disproportion led to the patient having an elective cesarean section at 39 weeks 3 days of gestation and she delivered a female infant weighing 2785 g...
July 2021: Case Reports in Women's Health
https://read.qxmd.com/read/33609795/bone-health-in-idiopathic-inflammatory-myopathies
#13
REVIEW
Miriam Cox, Robert D Sandler, Marco Matucci-Cerinic, Michael Hughes
OBJECTIVE: To review the extant literature relating to bone health in the idiopathic inflammatory myopathies (IIM) including both adult and juvenile patients. METHODS: A PubMed search® identified relevant studies from 1966 to 2020 in accordance with PRISMA guidelines. Two independent reviewers screened and extracted the abstracts/full manuscripts, and a third author was consulted in the case of disagreement. RESULTS: We identified 37 articles (3 review articles, 2 RCTs, 9 cross-sectional, 16 cohort and 7 case-control studies)...
April 2021: Autoimmunity Reviews
https://read.qxmd.com/read/33515210/effect-of-interleukin-6-17-21-22-and-23-and-stat3-on-signal-transduction-pathways-and-their-inhibition-in-autoimmune-arthritis
#14
REVIEW
Izabela Woś, Jacek Tabarkiewicz
Rheumatic diseases are complex autoimmune diseases which include among others rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and psoriatic arthritis (PsA). These diseases are characterized by prolonged and increased secretion of inflammatory factors, eventually leading to inflammation. This is often accompanied by persistent pain and stiffness in the joint and finally bone destruction and osteoporosis. These diseases can occur at any age, regardless of gender or origin. Autoimmune arthritis is admittedly associated with long-term treatment, and discontinuation of medication is associated with unavoidable relapse...
February 2021: Immunologic Research
https://read.qxmd.com/read/33141069/bisphosphonates-in-veterinary-medicine-the-new-horizon-for-use
#15
JOURNAL ARTICLE
Larry J Suva, Alexis Cooper, Ashlee E Watts, Frank H Ebetino, Joanna Price, Dana Gaddy
Bisphosphonates (BPs) are characterized by their ability to bind strongly to bone mineral and inhibit bone resorption. However, BPs exert a wide range of pharmacological activities beyond the inhibition of bone resorption, including the inhibition of cancer cell metastases and angiogenesis and the inhibition of proliferation and apoptosis in vitro. Additionally, the inhibition of matrix metalloproteinase activity, altered cytokine and growth factor expression, as well as reductions in parameters of pain have also been reported...
January 2021: Bone
https://read.qxmd.com/read/32960409/do-bisphosphonates-alleviate-pain-in-children-a-systematic-review
#16
JOURNAL ARTICLE
Mercedes Rodriguez Celin, Jackeline C Simon, Joseph J Krzak, Alissa V Fial, Karen M Kruger, Peter A Smith, Gerald F Harris
PURPOSE OF REVIEW: The goal of this systematic review is to analyze the effectiveness of bisphosphonates (BPs) to treat bone pain in children and adolescents who have diseases with skeletal involvement. RECENT FINDINGS: We included 24 studies (2 randomized controlled trials, 3 non-randomized controlled trials, 10 non-randomized open-label uncontrolled studies, 8 retrospective studies, and 1 study with design not specified). The majority of included studies assessed pain from a unidimensional approach, with pain intensity the most frequently evaluated dimension...
October 2020: Current Osteoporosis Reports
https://read.qxmd.com/read/32880031/insights-into-the-knowledge-attitude-and-practices-for-the-treatment-of-idiopathic-inflammatory-myopathy-from-a-cross-sectional-cohort-survey-of-physicians
#17
JOURNAL ARTICLE
Latika Gupta, Hafis Muhammed, R Naveen, Rajat Kharbanda, Harikrishnan Gangadharan, Durga P Misra, James B Lilleker, Hector Chinoy, Vikas Agarwal
The idiopathic inflammatory myopathies (IIM) are heterogeneous and lead to high morbidity and mortality. Knowledge deficits among healthcare professionals could be detrimental to clinical care. Identifying areas of deficient Knowledge, Attitude and Practice (KAP) of IIM can improve physician education and patient outcomes. To assess the proportion of physicians treating IIM with poor KAP and identify the key areas of deficit. An anonymised and validated e-survey (57 questions) was circulated among physicians treating IIM (purposive sampling)...
December 2020: Rheumatology International
https://read.qxmd.com/read/31340943/antiresorptive-associated-spontaneous-fractures-of-both-tibiae-followed-by-an-atypical-femur-fracture-during-the-sequential-treatment-with-alendronate-denosumab-then-teriparatide
#18
REVIEW
Juan Tan, Hiroshige Sano, Kenneth Poole
A 35-year-old man with juvenile idiopathic arthritis since childhood presented with bilateral atypical tibial fractures, followed by a later, single atypical fracture of the femur. The fractures were associated with 6 years of oral alendronate treatment immediately followed by subcutaneous denosumab therapy and later teriparatide therapy for osteoporosis. Atypical fractures are known to occur in the femur following bisphosphonate therapy; however, there are only a few documented cases of atypical fractures in the tibia...
July 23, 2019: BMJ Case Reports
https://read.qxmd.com/read/30948682/tofacitinib-treatment-of-refractory-systemic-juvenile-idiopathic-arthritis
#19
JOURNAL ARTICLE
Zhixiang Huang, Pui Y Lee, Xiaoyan Yao, Shaoling Zheng, Tianwang Li
Systemic juvenile idiopathic arthritis (sJIA) is an aggressive form of childhood arthritis accompanied by persistent systemic inflammation. Patients with sJIA often exhibit poor response to conventional disease-modifying antirheumatic drugs, and chronic glucocorticoid use is associated with significant adverse effects. Although biologics used to target interleukin 1 and interleukin 6 are efficacious, the long-term commitment to frequent injections or infusions remains a challenge in young children. Janus-activated kinase (JAK) inhibitors block the signaling of numerous proinflammatory cytokines and are now used clinically for the treatment of rheumatoid arthritis in adults...
May 2019: Pediatrics
https://read.qxmd.com/read/29850656/is-it-possible-to-predict-a-risk-of-osteoporosis-in-patients-with-juvenile-idiopathic-arthritis-a-study-of-serum-levels-of-bone-turnover-markers
#20
JOURNAL ARTICLE
Marta Janicka-Szczepaniak, Krzysztof Orczyk, Katarzyna Szymbor, Danuta Chlebna-Sokół, Elzbieta Smolewska
BACKGROUND: Low bone mineral density is a common finding in children with systemic connective tissue diseases, including juvenile idiopathic arthritis (JIA). The influence of the ongoing process of bone remodeling on the disease course merits further investigation. The aim of this study was to assess the clinical relevance of markers of bone turnover and their potential role as predictors of higher fracture risk and, by extension, risk of osteoporosis. MATERIALS AND METHODS: Blood samples were collected from 59 patients diagnosed with JIA in order to determine serum levels of the following markers of bone turnover: Beta-Crosslaps, osteocalcin, bone alkaline phosphatase, osteoprotegerin and receptor activator for nuclear factor kappa-B ligand...
2018: Acta Biochimica Polonica
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