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https://www.readbyqxmd.com/read/28340044/oral-ghrelin-receptor-agonist-mk-0677-increases-serum-insulin-like-growth-factor-1-in-hemodialysis-patients-a-randomized-blinded-study
#1
Garland A Campbell, James T Patrie, Bruce D Gaylinn, Michael O Thorner, Warren K Bolton
Background: . Protein-energy wasting (PEW) in end-stage renal disease (ESRD) patients is associated with increased morbidity and mortality, but options for treatment are limited. Growth hormone (GH) increases insulin-like growth factor 1 (IGF-1), with improved nutritional parameters, but must be given subcutaneously and does not provide normal GH secretion patterns. MK-0677, an oral ghrelin receptor agonist (GRA), maintains normal GH secretion and increases lean body mass in normal subjects; it has not been studied in dialysis patients, an essential step in assessing efficacy and safety prior to clinical trials...
March 3, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339523/factors-affecting-the-quality-of-life-of-chronic-dialysis-patients
#2
Beata Jankowska-Polanska, Izabella Uchmanowicz, Agata Wysocka, Bartosz Uchmanowicz, Katarzyna Lomper, Andrzej M Fal
: Patients on hemodialysis must adjust their life plans to the treatment. They are aware of losing their health and independence. Therefore, acceptance of illness (AI) is important and allows the patient to adjust to new situation and alleviates negative emotions The aim of study was to assess the impact of AI and other socioclinical variables on hemodialysis patients' quality of life (QoL).The study included 100 patients aged 20-85 (M = 57), treated with hemodialysis for at least 2 years. Two validated instruments were used: the Acceptance of Illness Scale (AIS) and the World Health Organization Quality of Life questionnaire...
October 19, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/28337715/is-incremental-hemodialysis-ready-to-return-on-the-scene-from-empiricism-to-kinetic-modelling
#3
REVIEW
Carlo Basile, Francesco Gaetano Casino, Kamyar Kalantar-Zadeh
Most people who make the transition to maintenance dialysis therapy are treated with a fixed dose thrice-weekly hemodialysis regimen without considering their residual kidney function (RKF). The RKF provides effective and naturally continuous clearance of both small and middle molecules, plays a major role in metabolic homeostasis, nutritional status, and cardiovascular health, and aids in fluid management. The RKF is associated with better patient survival and greater health-related quality of life, although these effects may be confounded by patient comorbidities...
March 23, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28325860/economic-costs-of-automated-and-continuous-ambulatory-peritoneal-dialysis-in-taiwan-a-combined-survey-and-retrospective-cohort-analysis
#4
Chao-Hsiun Tang, Yu-Ting Wu, Siao-Yuan Huang, Hsi-Hsien Chen, Ming-Ju Wu, Bang-Gee Hsu, Jer-Chia Tsai, Tso-Hsiao Chen, Yuh-Mou Sue
OBJECTIVES: Taiwan succeeded in raising the proportion of peritoneal dialysis (PD) usage after the National Health Insurance (NHI) payment scheme introduced financial incentives in 2005. This study aims to compare the economic costs between automated PD (APD) and continuous ambulatory PD (CAPD) modalities from a societal perspective. DESIGN AND SETTING: A retrospective cohort of patients receiving PD from the NHI Research Database was identified during 2004-2011...
March 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28321327/physical-activity-in-patients-treated-with-peritoneal-dialysis-a-protocol-for-a-systematic-review
#5
Tharshika Thangarasa, Rameez Imtiaz, Swapnil Hiremath, Deborah Zimmerman
BACKGROUND: Patients with chronic diseases are known to benefit from exercise. Despite a lack of compelling evidence, patients with end-stage kidney disease treated with peritoneal dialysis are often discouraged from participating in exercise programs that include resistance training due to concerns about the development of hernias and leaks. The actual effects of physical activity with or without structured exercise programs for these patients remain unclear. The purpose of this study is to more completely define the risks and benefits of physical activity in the end-stage kidney disease population treated with peritoneal dialysis...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28316636/the-siesta-trial-a-randomized-study-investigating-the-efficacy-safety-and-tolerability-of-acupressure-versus-sham-therapy-for-improving-sleep-quality-in-patients-with-end-stage-kidney-disease-on-hemodialysis
#6
Kunyu Shen, Yeoungjee Cho, Elaine M Pascoe, Carmel M Hawley, Veronica Oliver, Kathryn M Hughes, Richard Baer, Jeremy Frazier, Elizabeth Jarvis, Ken-Soon Tan, Xusheng Liu, Glenda Gobe, David W Johnson
Objectives. To compare the effectiveness of real acupressure versus sham acupressure therapy in improving sleep quality in patients receiving hemodialysis (HD) or hemodiafiltration (HDF). Methods. A multicenter, single-blind, randomized controlled trial was conducted in two Australian dialysis units located in Princess Alexandra Hospital and Logan Hospital, respectively. Forty-two subjects with self-reported poor sleep quality were randomly assigned to real (n = 21) or sham (n = 21) acupressure therapy delivered thrice weekly for four consecutive weeks during routine dialysis sessions...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28316002/the-impact-of-periodontal-disease-on-physical-and-psychological-domains-in-long-term-hemodialysis-patients-a-cross-sectional-study
#7
Gabriel Veisa, Alexandra Tasmoc, Ionut Nistor, Liviu Segall, Dimitrie Siriopol, Sorina Mihaela Solomon, Mihaela Dora Donciu, Luminita Voroneanu, Andra Nastasa, Adrian Covic
PURPOSE: Periodontal disease is a chronic infectious disease. Individuals with end-stage kidney disease (ESKD) experience impaired quality of life (QoL) and low oral health. This is the first comprehensive study which aimed to explore the link between periodontal disease and quality of life, assessed with the Short Form 36-Item Health Survey in hemodialysis patients. METHODS: In total, 101 patients (57 females) with ESKD were recruited from two Romanian dialysis centers...
March 18, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28314806/the-use-of-a-multidimensional-measure-of-dialysis-adequacy-moving-beyond-small-solute-kinetics
#8
REVIEW
Jeffrey Perl, Laura M Dember, Joanne M Bargman, Teri Browne, David M Charytan, Jennifer E Flythe, LaTonya J Hickson, Adriana M Hung, Michel Jadoul, Timmy Chang Lee, Klemens B Meyer, Hamid Moradi, Tariq Shafi, Isaac Teitelbaum, Leslie P Wong, Christopher T Chan
Urea removal has become a key measure of the intensity of dialysis treatment for kidney failure. Small solute removal, exemplified by Kt/Vurea, has been broadly applied as a means to quantify the dose of thrice weekly hemodialysis. Yet, the reliance on small solute clearances alone as a measure of dialysis adequacy fails fully to quantify the intended clinical effects of dialysis therapy. This review aims to (1) understand the strengths and limitations of small solute kinetics as a surrogate marker of dialysis dose, and (2) present the prospect of a more comprehensive construct for dialysis dose, one that considers more broadly the goals of ESRD care to maximize both quality of life and survival...
March 17, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28306566/anemia-management-in-chronic-kidney-disease-and-dialysis-a-narrative-review
#9
David Collister, Claudio Rigatto, Navdeep Tangri
PURPOSE OF REVIEW: This review describes the current state of anemia management with erythropoietin (EPO)-stimulating agents and iron supplementation in both chronic kidney disease and dialysis patients, with a focus on novel therapies. RECENT FINDINGS: We review the benefits and risks of EPO-stimulating agents, focusing on health-related quality of life and the uncertainties regarding optimal iron utilization in patients with kidney disease. We discuss novel therapies for iron supplementation including iron-based phosphate binders and dialysate iron delivery as well as alternatives to EPO-stimulating agents including hypoxia-inducible factor prolyl hydroxylase inhibitors...
March 16, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28304402/prospective-longitudinal-study-on-quality-of-life-in-relapsed-refractory-multiple-myeloma-patients-receiving-second-or-third-line-lenalidomide-or-bortezomib-treatment
#10
X Leleu, C Kyriakou, I Vande Broek, P Murphy, P Bacon, P Lewis, H Gilet, B Arnould, M T Petrucci
Treatment advances for multiple myeloma (MM) that have prolonged survival emphasise the importance of measuring patients' health-related quality of life (HRQoL) in clinical studies. HRQoL/functioning and symptoms of patients with relapsed/refractory MM (RRMM) receiving second- or third-line lenalidomide or bortezomib treatment were measured in a prospective European multicentre, observational study at different time points. At baseline, patients in the lenalidomide cohort were frailer than in the bortezomib cohort with more rapid disease progression at study entry (more patients with Eastern Cooperative Oncology Group performance status >2, shorter time from diagnosis, more chronic heart failure, higher serum creatinine levels, more patients with dialysis required)...
March 17, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28295744/contributing-factors-for-therapeutic-diet-adherence-in-patients-receiving-haemodialysis-treatment-an-integrative-review
#11
REVIEW
Lissete González Oquendo, José Miguel Morales Asencio, Candela Bonill de Las Nieves
AIMS AND OBJECTIVES: The objective of this integrative review is to identify the factors that contribute to diet adherence in people suffering from kidney disease who are receiving haemodialysis treatment. BACKGROUND: Adherence to the therapeutic regimen determines therapeutic success, quality of life, and survival in patients on haemodialysis. Lack of diet adherence ranges from 25 to 86% in patients receiving haemodialysis treatment and affects patient morbidity and mortality...
March 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28295607/incremental-hemodialysis-the-university-of-california-irvine-experience
#12
Mehrdad Ghahremani-Ghajar, Vanessa Rojas-Bautista, Wei-Ling Lau, Madeleine Pahl, Miguel Hernandez, Anna Jin, Uttam Reddy, Jason Chou, Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Connie M Rhee
Incremental hemodialysis has been examined as a viable hemodialysis regimen for selected end-stage renal disease (ESRD) patients. Preservation of residual kidney function (RKF) has been the driving impetus for this approach given its benefits upon the survival and quality of life of dialysis patients. While clinical practice guidelines recommend an incremental start of dialysis in peritoneal dialysis patients with substantial RKF, there remains little guidance with respect to incremental hemodialysis as an initial renal replacement therapy regimen...
March 14, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28291652/cost-effectiveness-of-hospital-treatment-and-outcomes-of-acute-methanol-poisoning-during-the-czech-republic-mass-poisoning-outbreak
#13
Jan Rulisek, Martin Balik, Ferdinand Polak, Petr Waldauf, Daniela Pelclova, Jan Belohlavek, Sergey Zakharov
PURPOSE: During an outbreak of mass methanol poisoning in the Czech Republic in 2012-2014, we compared the total hospital costs and one-year medical costs in the patients treated with different antidotes (fomepizole versus ethanol) and modalities of hemodialysis (intermittent hemodialysis, IHD, versus continuous renal replacement therapy, CRRT). METHODS: Cross-sectional study in 106 patients with confirmed diagnosis treated in 30 ICU settings. For each patient, the following data were analyzed: admission laboratory data, GCS, PSS, ICU length of stay, organ failures, treatment, outcome, and total hospital costs...
March 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28291581/a-real-world-cost-effectiveness-analysis-of-sevelamer-versus-calcium-acetate-in-korean-dialysis-patients
#14
Jang-Hee Cho, Hye Min Jang, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Chul Woo Yang, Dong-Chan Jin, Yong-Lim Kim
PURPOSE: Sevelamer, a noncalcium phosphate binder, has been shown to attenuate the progression of vascular calcification and improve survival in patients with chronic kidney disease undergoing dialysis compared with calcium-based binders. Using real-world data from a cohort study and the Health Insurance Review and Assessment Service database, we conducted a cost-effectiveness analysis comparing sevelamer with calcium acetate in dialysis patients from the perspective of the National Health Insurance Service in South Korea...
March 10, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28289413/mica-and-nkg2d-is-there-an-impact-on-kidney-transplant-outcome
#15
REVIEW
Matilde Risti, Maria da Graça Bicalho
This paper aims to present an overview of MICA and natural killer group 2 member D (NKG2D) genetic and functional interactions and their impact on kidney transplant outcome. Organ transplantation has gone from what can accurately be called a "clinical experiment" to a routine and reliable practice, which has proven to be clinically relevant, life-saving and cost-effective when compared with non-transplantation management strategies of both chronic and acute end-stage organ failures. The kidney is the most frequently transplanted organ in the world (transplant-observatory)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28277013/examining-the-efficacy-of-social-psychological-interventions-for-the-management-of-fatigue-in-end-stage-kidney-disease-eskd-a-systematic-review-with-meta-analysis
#16
Federica Picariello, Joanna L Hudson, Rona Moss-Morris, Iain C Macdougall, Joseph Chilcot
Fatigue affects between 42% and 89% of end-stage kidney disease (ESKD) patients, with significant repercussions on quality of life and clinical outcomes. Fatigue management revolves around pharmacotherapy or exercise, which have only modest and short-term improvements. The aim of this systematic review was to investigate whether social-psychological interventions are effective at reducing fatigue in ESKD. Databases were searched to identify randomized controlled trials (RCTs) and quasi-RCTs that determined the effect of social-psychological interventions on fatigue (primary or secondary outcome), in the renal patient population...
March 6, 2017: Health Psychology Review
https://www.readbyqxmd.com/read/28270642/kidney-disease-profile-of-syrian-refugee-children
#17
Mehtap Akbalik Kara, Beltinge Demircioglu Kilic, Nilgun Col, Ayse Aysima Ozcelik, Mithat Buyukcelik, Ayse Balat
INTRODUCTION: Although preventative nephrology is the effective management of childhood kidney diseases, it is hard to provide it in this undesirable conditions. In this study, we aimed to document the kidney disease profile of Syrian refugee children admitted to our hospital. MATERIALS AND METHODS: One hundred and thirty Syrian refugee children were admitted to the Pediatric Nephrology Department of the University of Gaziantep from September 2012 to January 2015...
March 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28270640/prevalence-of-depression-in-hemodialysis-patients-in-iran-a-systematic-review-and-meta-analysis
#18
Hamid Ravaghi, Masoud Behzadifar, Meysam Behzadifar, Masood Taheri Mirghaed, Aidin Aryankhesal, Morteza Salemi, Nicola Luigi Bragazzi
INTRODUCTION: Chronic kidney disease is a public health problem worldwide that is highly associated with psychological disorders. This study aimed to assess prevalence of depression in hemodialysis patients in Iran. MATERIALS AND METHODS: Relevant studies were identified from the PubMed, ISI Web of Science, Ovid, Scopus, EMBase, and Iranian databases including Magiran, SID, IranMedex, and Irandoc, up to December 2015. The DerSimonian-Laird random effects model was employed to estimate the overall pooled prevalence...
March 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28268711/nanoporous-membrane-robustness-stability-in-small-form-factor-microfluidic-filtration-system
#19
Dean G Johnson, Sabrina Pan, Andrew Hayden, James L McGrath
The development of wearable hemodialysis (HD) devices that replace center-based HD holds the promise to improve both outcomes and quality-of-life for patients with end-stage-renal disease (ERD). A prerequisite for these devices is the development of highly efficient membranes that can achieve high toxin clearance in small footprints. The ultrathin nanoporous membrane material developed by our group is orders of magnitude more permeable than conventional HD membranes. We report on our progress making a prototype wearable dialysis unit...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268708/evaluation-of-biofouling-for-implantable-micro-dialysis-system
#20
T Ota, N To, Y Kanno, N Miki
Implantable artificial kidney can drastically improve the quality of life of the renal disease patients. In previous study, our group has developed a multi-layered micro dialysis device which is composed of micro stainless steel channels and nano-porous polyethersulfone (PES) membranes. The device conducts hemofiltration without dialysis fluids, which is advantageous in miniaturization. We investigated the water-permeability of the PES membrane through in vivo experiments using rat model of renal disease for 5 hours and verified the effectiveness of the device...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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