keyword
https://read.qxmd.com/read/37953848/reduced-evoked-cortical-beta-and-gamma-activity-and-neuronal-synchronization-in-succinic-semialdehyde-dehydrogenase-deficiency-a-disorder-of-%C3%AE-aminobutyric-acid-metabolism
#21
JOURNAL ARTICLE
Christos Papadelis, Georgios Ntolkeras, Itay Tokatly Latzer, Melissa L DiBacco, Onur Afacan, Simon Warfield, Xutong Shi, Jean-Baptiste Roullet, K Michael Gibson, Phillip L Pearl
Succinic semialdehyde dehydrogenase deficiency is a rare autosomal recessively inherited metabolic disorder of γ-aminobutyric acid catabolism manifested by intellectual disability, expressive aphasia, movement disorders, psychiatric ailments and epilepsy. Subjects with succinic semialdehyde dehydrogenase deficiency are characterized by elevated γ-aminobutyric acid and related metabolites, such as γ-guanidinobutyric acid, and an age-dependent downregulation of cerebral γ-aminobutyric acid receptors...
2023: Brain communications
https://read.qxmd.com/read/37874983/reduced-insulin-clearance-differently-relates-to-increased-liver-lipid-content-and-worse-glycemic-control-in-recent-onset-type-2-and-type-1-diabetes
#22
JOURNAL ARTICLE
Oana-Patricia Zaharia, Sofia Antoniou, Pavel Bobrov, Yanislava Karusheva, Kálmán Bódis, Yuliya Kupriyanova, Vera Schrauwen-Hinderling, Amalia Gastaldelli, Julia Szendroedi, Robert Wagner, Volker Burkart, Michael Roden
OBJECTIVE: Diabetes may feature impaired insulin kinetics, which could be aggravated by altered hepatic metabolism and glycemic control. Thus, we examined insulin clearance and its possible determinants in individuals with recent-onset diabetes. RESEARCH DESIGN AND METHODS: Participants of the German Diabetes Study (GDS) with type 1 diabetes (T1D) (n = 306), type 2 diabetes (T2D) (n = 489), or normal glucose tolerance (control [CON]) (n = 167) underwent hyperinsulinemic-euglycemic clamps for assessment of whole-body insulin sensitivity (M value) and insulin clearance (ICCLAMP)...
October 24, 2023: Diabetes Care
https://read.qxmd.com/read/37869290/comparative-study-of-bilateral-putamen-for-patients-with-severe-parkinson-s-disease-detected-by-1-h-magnetic-resonance-spectroscopy
#23
JOURNAL ARTICLE
Biao Qu, Xiaoyuan Li, Min Xiao, Runhan Chen, Hejuan Tan, Hongwei Sun, Rushuai Li, Jingjing Xu, Jiyang Dong, Gaofeng Zheng, Shuyue Ai, Xiaobo Qu
BACKGROUND: The diagnosis of Parkinson's disease (PD) is challenging because the clinical symptoms overlap with other neurodegenerative diseases. The discovery of reliable biomarkers is highly expected to facilitate clinical diagnosis. Through the analysis of the 1 H magnetic resonance spectroscopy (1 H-MRS) in the putamen, the purpose of the study was to discuss the possibility of the difference in metabolite concentrations between the left and right putamen as biomarkers for patients with severe PD...
October 1, 2023: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/37867757/hamstring-muscle-fibre-typology-is-not-associated-with-hamstring-strain-injury-history-or-performance-in-amateur-male-soccer-players-a-retrospective-magnetic-resonance-spectroscopy-study
#24
JOURNAL ARTICLE
Joke Schuermans, Erik Witvrouw, Evi Wezenbeek, Eline Lievens
Hamstring strain injuries (HSI) are still the most common injuries in soccer. Recent research has been focusing on the role of hamstring muscle morphology and architecture. The hamstring's fibre type composition might play a role as well, but this has never been investigated in the light of HSI risk in an athletic population. The purpose of this study was to investigate the association between hamstring muscle fibre type, hamstring strain injury history (HSIH), performance and isokinetic strength in a population of amateur male soccer players...
October 2023: Biology of Sport
https://read.qxmd.com/read/37821173/altered-in-utero-metabolic-brain%C3%A2-trajectories-in-chd-going-beyond-fetal-brain-structure-and-physiology
#25
EDITORIAL
Ashok Panigrahy, Stefan Blüml, Vidya Rajagopalan
No abstract text is available yet for this article.
October 17, 2023: Journal of the American College of Cardiology
https://read.qxmd.com/read/37817131/spectroscopic-abnormalities-in-the-pregenual-anterior-cingulate-cortex-in-obsessive-compulsive-disorder-using-proton-magnetic-resonance-spectroscopy-a-controlled-study
#26
JOURNAL ARTICLE
Eliška Kosová, Dita Pajuelo, Iveta Fajnerová, David Greguš, Martin Brunovský, Pavla Stopková, Antonín Škoch, Petra Fürstová, Filip Španiel, Jiří Horáček
BACKGROUND: The main aim of the present study is to determine the role of metabolites observed using proton magnetic resonance spectroscopy (1H-MRS) in obsessive-compulsive disorder (OCD). As the literature describing biochemical changes in OCD yields conflicting results, we focused on accurate metabolite quantification of total N-acetyl aspartate (tNAA), total creatine (tCr), total choline-containing compounds (tCh), and myo-inositol (mI) in the anterior cingulate cortex (ACC) to capture the small metabolic changes between OCD patients and controls and between OCD patients with and without medication...
October 10, 2023: BMC Psychiatry
https://read.qxmd.com/read/37794648/automated-analysis-of-the-total-choline-resonance-peak-in-breast-proton-magnetic-resonance-spectroscopy
#27
JOURNAL ARTICLE
Domagoj Javor, Barbara I Bennani-Baiti, Paola Clauser, Daria Kifjak, Pascal A T Baltzer
The aim of the current study was to compare the performance of fully automated software with human expert interpretation of single-voxel proton magnetic resonance spectroscopy (1H-MRS) spectra in the assessment of breast lesions. Breast magnetic resonance imaging (MRI) (including contrast-enhanced T1-weighted, T2-weighted, and diffusion-weighted imaging) and 1H-MRS images of 74 consecutive patients were acquired on a 3-T positron emission tomography-MRI scanner then automatically imported into and analyzed by SpecTec-ULR 1...
October 4, 2023: NMR in Biomedicine
https://read.qxmd.com/read/37777087/early-rise-of-glutamate-glutamine-levels-in-mild-cognitive-impairment-evidence-for-emerging-excitotoxicity
#28
JOURNAL ARTICLE
Laura Velu, Luc Pellerin, Adrien Julian, Marc Paccalin, Clément Giraud, Pierre Fayolle, Rémy Guillevin, Carole Guillevin
BACKGROUND: Use proton magnetic resonance spectroscopy (1H-MRS) non invasive technique to assess the modifications of glutamate-glutamine (Glx) and gammaaminobutyric acid (GABA) brain levels in patients reporting a cognitive complain METHODS: Posterior cingular cortex 1H-MRS spectra of 46 patients (19 male, 27 female) aged 57 to 87 years (mean : 73.32 ± 7.33 years) with a cognitive complaint were examined with a MEGA PRESS sequence at 3T, and compounds Glutamateglutamine (Glx), GABA, Creatine (Cr) and NAA were measured...
September 28, 2023: Journal of Neuroradiology. Journal de Neuroradiologie
https://read.qxmd.com/read/37766785/gaba-a-receptor-availability-relates-to-emotion-induced-bold-responses-in-the-medial-prefrontal-cortex-simultaneous-fmri-pet-with-11-c-flumazenil
#29
JOURNAL ARTICLE
Alexander Heinzel, Jörg Mauler, Hans Herzog, Frank Boers, Felix M Mottaghy, Karl-Josef Langen, Jürgen Scheins, Christoph Lerche, Bernd Neumaier, Georg Northoff, N Jon Shah
INTRODUCTION: The fMRI BOLD response to emotional stimuli highlighting the role of the medial prefrontal cortex (MPFC) has been thoroughly investigated. Recently, the relationship between emotion processing and GABA levels has been studied using MPFC proton magnetic resonance spectroscopy (1H-MRS). However, the role of GABAA receptors in the MPFC during emotion processing remains unexplored. METHODS: Using [11C]flumazenil PET, we investigated the relationship between the binding potential of GABAA receptors and emotion processing as measured using simultaneous fMRI BOLD...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/37752221/glutamatergic-basis-of-antipsychotic-response-in-first-episode-psychosis-a-dual-voxel-study-of-the-anterior-cingulate-cortex
#30
JOURNAL ARTICLE
Lejia Fan, Liangbing Liang, Yujue Wang, Xiaoqian Ma, Liu Yuan, Lijun Ouyang, Ying He, Zongchang Li, Chunwang Li, Xiaogang Chen, Lena Palaniyappan
A subgroup of patients with schizophrenia is believed to have aberrant excess of glutamate in the frontal cortex; this subgroup is thought to show poor response to first-line antipsychotic treatments that focus on dopamine blockade. If we can identify this subgroup early in the course of illness, we can reduce the repeated use of first-line antipsychotics and potentially stratify first-episode patients to intervene early with second-line treatments such as clozapine. The use of proton magnetic resonance spectroscopy (1H-MRS) to measure glutamate and Glx (glutamate plus glutamine) may provide a means for such a stratification...
September 26, 2023: Neuropsychopharmacology
https://read.qxmd.com/read/37735222/impact-of-cannabis-use-on-brain-metabolism-using-31-p-and-1-h-magnetic-resonance-spectroscopy
#31
JOURNAL ARTICLE
Maximilian Fenzl, Martin Backens, Silviu Bodea, Miriam Wittemann, Florian Werler, Jule Brielmaier, Robert Christian Wolf, Wolfgang Reith
PURPOSE: This prospective cross-sectional study investigated the influence of regular cannabis use on brain metabolism in young cannabis users by using combined proton and phosphorus magnetic resonance spectroscopy. METHODS: The study was performed in 45 young cannabis users aged 18-30, who had been using cannabis on a regular basis over a period of at least 2 years and in 47 age-matched controls. We acquired 31P MRS data in different brain regions at 3T with a double-resonant 1H/31P head coil, anatomic images, and 1H MRS data with a standard 20-channel 1H head coil...
November 2023: Neuroradiology
https://read.qxmd.com/read/37720681/brain-glutathione-increase-and-seizure-burden-decrease-in-patients-with-intractable-epilepsy-on-ketogenic-diet
#32
JOURNAL ARTICLE
Saman Hazany, Brittany DeClouette, Jessica Lowe, Darryl H Hwang, Paul E Kim, Stefan Bluml, Arthur Partikian
BACKGROUND AND PURPOSE: Ketogenic diet (KD) improves seizure control in patients with drug-resistant epilepsy. As increased mitochondrial levels of glutathione (GSH) might contribute to a change in seizure susceptibility, we quantified changes of absolute GSH levels in the brain by in vivo 1H magnetic resonance spectroscopy (1H MRS) and correlate that with degree of seizure control in patients on KD. METHODS: Five cognitively normal adult patients with drug-resistant epilepsy were initially included and 2 completed the study...
June 30, 2023: Journal of Epilepsy Research
https://read.qxmd.com/read/37688998/role-of-brain-metabolites-during-acute-phase-of-mild-traumatic-brain-injury-in-prognosis-of-post-concussion-syndrome-a-1h-mrs-study
#33
JOURNAL ARTICLE
Mohammad Haghani Dogahe, Sara Ramezani, Zoheir Reihanian, Samira Raminfard, Alireza Feizkhah, Babak Alijani, Sina Sedaghat Herfeh
This study has investigated the potency and accuracy of early magnetic resonance spectroscopy (MRS) to predict post-concussion syndrome (PCS) in adult patients with a single mild traumatic brain injury (mTBI) without abnormality on a routine brain scan. A total of 48 eligible mTBI patients and 24 volunteers in the control group participated in this project. Brain MRS over regions of interest (ROI) and signal stop task (SST) were done within the first 72 hours of TBI onset. After six months, PCS appearance and severity were determined...
August 28, 2023: Psychiatry Research. Neuroimaging
https://read.qxmd.com/read/37656734/using-the-metabolite-alterations-monitoring-the-aeg-1-expression-level-and-cell-biological-behaviour-of-u251-cell-in-vitro
#34
JOURNAL ARTICLE
Yurui Sheng, Di Yin, Qingshi Zeng
Astrocyte elevated gene-1 (AEG-1) is an important oncogene that overexpresses in gliomas and plays a vital role in their occurrence and progression. However, few reports have shown which biomarkers could reflect the level of AEG-1 expression in vivo so far. In recent years, intracellular metabolites monitored by proton magnetic resonance spectroscopy (1H MRS) as non-invasive imaging biomarkers have been applied to the precise diagnosis and therapy feedback of gliomas. Therefore, understanding the correlation between 1H MRS metabolites and AEG-1 gene expression in U251 cells may help to identify relevant biomarkers...
2023: PloS One
https://read.qxmd.com/read/37626897/alzheimer-s-disease-like-pathological-features-in-the-dorsal-hippocampus-of-wild-type-rats-subjected-to-methionine-diet-evoked-mild-hyperhomocysteinaemia
#35
JOURNAL ARTICLE
Maria Kovalska, Petra Hnilicova, Dagmar Kalenska, Marian Adamkov, Libusa Kovalska, Jan Lehotsky
Multifactorial interactions, including nutritional state, likely participate in neurodegeneration's pathogenesis and evolution. Dysregulation in methionine (Met) metabolism could lead to the development of hyperhomocysteinaemia (hHcy), playing an important role in neuronal dysfunction, which could potentially lead to the development of Alzheimer's disease (AD)-like pathological features. This study combines proton magnetic resonance spectroscopy (1 H MRS) with immunohistochemical analysis to examine changes in the metabolic ratio and histomorphological alterations in the dorsal rat hippocampus (dentate gyrus-DG) subjected to a high Met diet...
August 17, 2023: Cells
https://read.qxmd.com/read/37471385/perturbed-neurochemical-and-microstructural-organization-in-a-mouse-model-of-prenatal-opioid-exposure-a-multi-modal-magnetic-resonance-study
#36
JOURNAL ARTICLE
Syed Salman Shahid, Gregory G Grecco, Brady K Atwood, Yu-Chien Wu
Methadone-based treatment for pregnant women with opioid use disorder is quite prevalent in the clinical environment. A number of clinical and animal model-based studies have reported cognitive deficits in infants prenatally exposed to methadone-based opioid treatments. However, the long-term impact of prenatal opioid exposure (POE) on pathophysiological mechanisms that govern neurodevelopmental impairment is not well understood. Using a translationally relevant mouse model of prenatal methadone exposure (PME), the aim of this study is to investigate the role of cerebral biochemistry and its possible association with regional microstructural organization in PME offspring...
2023: PloS One
https://read.qxmd.com/read/37456524/acute-effects-of-single-and-repeated-mild-traumatic-brain-injury-on-levels-of-neurometabolites-lipids-and-mitochondrial-function-in-male-rats
#37
JOURNAL ARTICLE
Josh Allen, Louise Pham, Simon T Bond, William T O'Brien, Gershon Spitz, Sandy R Shultz, Brian G Drew, David K Wright, Stuart J McDonald
INTRODUCTION: Mild traumatic brain injuries (mTBIs) are the most common form of acquired brain injury. Symptoms of mTBI are thought to be associated with a neuropathological cascade, potentially involving the dysregulation of neurometabolites, lipids, and mitochondrial bioenergetics. Such alterations may play a role in the period of enhanced vulnerability that occurs after mTBI, such that a second mTBI will exacerbate neuropathology. However, it is unclear whether mTBI-induced alterations in neurometabolites and lipids that are involved in energy metabolism and other important cellular functions are exacerbated by repeat mTBI, and if such alterations are associated with mitochondrial dysfunction...
2023: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/37415068/function-and-biochemistry-of-the-dorsolateral-prefrontal-cortex-during-placebo-analgesia-how-the-certainty-of-prior-experiences-shapes-endogenous-pain-relief
#38
JOURNAL ARTICLE
Lewis S Crawford, Emily P Mills, A Peek, Vaughan G Macefield, Kevin A Keay, Luke A Henderson
Prior experiences, conditioning cues, and expectations of improvement are essential for placebo analgesia expression. The dorsolateral prefrontal cortex is considered a key region for converting these factors into placebo responses. Since dorsolateral prefrontal cortex neuromodulation can attenuate or amplify placebo, we sought to investigate dorsolateral prefrontal cortex biochemistry and function in 38 healthy individuals during placebo analgesia. After conditioning participants to expect pain relief from a placebo "lidocaine" cream, we collected baseline magnetic resonance spectroscopy (1H-MRS) at 7 Tesla over the right dorsolateral prefrontal cortex...
July 6, 2023: Cerebral Cortex
https://read.qxmd.com/read/37398967/increased-brain-1-h-mrs-glutamate-and-lactate-signals-following-maximal-aerobic-capacity-exercise-in-young-healthy-males-an-exploratory-study
#39
JOURNAL ARTICLE
Maciej Świątkiewicz, Stefan Gaździński, Michał Madeyski, Bartosz Kossowski, Józef Langfort, Piotr Bogorodzki, Ewelina Zawadzka-Bartczak, Katarzyna Sklinda, Jerzy Walecki, Paweł Grieb
Physical exercise involves increased neuronal activity of many brain structures, but 1H-MRS investigations on the effects of human brain glutamate (Glu) concentrations on acute exercise have been sparse. Previous studies consistently found increases in brain lactate (Lac) concentrations following graded exercise up to 85% of the predicted maximal heart rate. However, the reported effects on brain concentrations of glutamine and glutamate were not consistent. This study aimed to determine the effect of acute intense graded maximal exercise on 1H-MRS signals related to concentrations of Glu, glutamate+glutamine (Glx), and Lac...
July 2023: Biology of Sport
https://read.qxmd.com/read/37379033/growth-hormone-administration-improves-nonalcoholic-fatty-liver-disease-in-overweight-obesity-a-randomized-trial
#40
RANDOMIZED CONTROLLED TRIAL
Laura E Dichtel, Kathleen E Corey, Melanie S Haines, Mark L Chicote, Hang Lee, Allison Kimball, Caitlin Colling, Tracey G Simon, Michelle T Long, Jad Husseini, Miriam A Bredella, Karen K Miller
CONTEXT: Overweight and obesity are associated with relative growth hormone (GH) deficiency, which has been implicated in the development of nonalcoholic fatty liver disease (NAFLD). NAFLD is a progressive disease without effective treatments. OBJECTIVE: We hypothesized that GH administration would reduce hepatic steatosis in individuals with overweight/obesity and NAFLD. METHODS: In this 6-month randomized, double-blind, placebo-controlled trial of low-dose GH administration, 53 adults aged 18 to 65 years with BMI ≥25 kg/m2 and NAFLD without diabetes were randomized to daily subcutaneous GH or placebo, targeting insulin-like growth factor 1 (IGF-1) to the upper normal quartile...
November 17, 2023: Journal of Clinical Endocrinology and Metabolism
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