keyword
https://read.qxmd.com/read/38494099/the-relationship-between-oxidative-stress-markers-and-1h-magnetic-resonance-spectroscopy-findings-in-obsessive-compulsive-disorder
#1
JOURNAL ARTICLE
Fatma Subaşı Turgut, Mahmut Bulut, Salih Hattapoğlu, Mehmet Güneş, Mehmet Cemal Kaya, Faysal Ekici, Mehmet Guli Çetinçakmak, İbrahim Kaplan, Murad Atmaca
INTRODUCTION: The purpose of this study was to examine N-acetyl aspartate (NAA)/creatine (Cr) and glutamate, glutamine, and gamma-aminobutyric acid complex (Glx)/Cr levels in patients with obsessive compulsive disorder (OCD) and healthy controls' orbitofrontal cortex (OFC) and caudate nucleus (CN) by proton magnetic resonance spectroscopy (1H-MRS) method and to investigate their relationship with oxidative stress markers glutathione peroxidase (GPx) and superoxide dismutase (SOD). METHODS: This study included patients with OCD (n = 25) and healthy controls (n = 25) ranging in age from 18 to 65...
March 15, 2024: Brain Research
https://read.qxmd.com/read/38434271/assessment-of-sepsis-associated-encephalopathy-by-quantitative-magnetic-resonance-spectroscopy-in-a-rat-model-of-cecal-ligation-and-puncture
#2
JOURNAL ARTICLE
Siqi Liu, Zhifeng Liu, Gongfa Wu, Haoyi Ye, Zhihua Wu, Zhengfei Yang, Shanping Jiang
Proton magnetic resonance spectroscopy (1H-MRS) is the only non-invasive technique to quantify neurometabolic compounds in the living brain. We used 1H-MRS to evaluate the brain metabolites in a rat model of Sepsis-associated encephalopathy (SAE) established by cecal ligation and puncture (CLP). 36 male Sprague-Dawley rats were randomly divided into sham and CLP groups. Each group was further divided into three subgroups: subgroup O, subgroup M, and subgroup N. Neurological function assessments were performed on the animals in the subgroup O and subgroup N at 24 h, 48 h, and 72 h...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38430105/the-developmental-trajectory-of-1h-mrs-brain-metabolites-from-childhood-to-adulthood
#3
JOURNAL ARTICLE
Alice R Thomson, Hannah Hwa, Duanghathai Pasanta, Benjamin Hopwood, Helen J Powell, Ross Lawrence, Zeus G Tabuenca, Tomoki Arichi, Richard A E Edden, Xiaoqian Chai, Nicolaas A Puts
Human brain development is ongoing throughout childhood, with for example, myelination of nerve fibers and refinement of synaptic connections continuing until early adulthood. 1H-Magnetic Resonance Spectroscopy (1H-MRS) can be used to quantify the concentrations of endogenous metabolites (e.g. glutamate and γ -aminobutyric acid (GABA)) in the human brain in vivo and so can provide valuable, tractable insight into the biochemical processes that support postnatal neurodevelopment. This can feasibly provide new insight into and aid the management of neurodevelopmental disorders by providing chemical markers of atypical development...
March 1, 2024: Cerebral Cortex
https://read.qxmd.com/read/38419937/resting-state-and-activated-brain-glutamate-glutamine-brain-lactate-cognition-and-psychopathology-among-males-with-schizophrenia-a-3-tesla-proton-magnetic-resonance-spectroscopic-1h-mrs-study
#4
JOURNAL ARTICLE
Ujjwal Singh, Basudeb Das, Sourav Khanra, Chandramouli Roy
BACKGROUND: Research on glutamate (Glu) in schizophrenia has so far been inconclusive. Based on preclinical studies on Glu lactate interaction, researchers have now focused on brain lactate level as a sign of major pathology, including cognitive dysfunctions in the brain. Our study aimed to examine changes at resting and activated states in brain lactate and Glu-glutamine (Glx) at the anterior cingulate cortex (ACC) in schizophrenia. METHODS: A hospital-based prospective study was conducted with twenty-two male cases of schizophrenia and matched healthy controls (HCs)...
January 2024: Indian Journal of Psychiatry
https://read.qxmd.com/read/38419647/preliminary-study-on-early-diagnosis-of-alzheimer-s-disease-in-app-ps1-transgenic-mice-using-multimodal-magnetic-resonance-imaging
#5
JOURNAL ARTICLE
Meng Xu, Jipeng Liu, Qingguo Liu, Yu Gong, Yinyin Li, Jing Zhang, Shufeng Shi, Yuanyuan Shi
Alzheimer's disease (AD) has an insidious onset and lacks clear early diagnostic markers, and by the time overt dementia symptoms appear, the disease is already in the mid-to-late stages. The search for early diagnostic markers of AD may open a critical window for Alzheimer's treatment and facilitate early intervention to slow the progression of AD. In this study, we aimed to explore the imaging markers for early diagnosis of AD through the combined application of structural magnetic resonance imaging (sMRI), resting-state functional magnetic resonance imaging (rs-fMRI), and 1 H-magnetic resonance spectroscopy (1 H-MRS) multimodal magnetic resonance imaging (MRI) techniques at the animal experimental level, with the aim to provide a certain reference for early clinical diagnosis of AD...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38414634/the-contribution-of-preclinical-magnetic-resonance-imaging-and-spectroscopy-to-huntington-s-disease
#6
REVIEW
Jean-Baptiste Pérot, Emmanuel Brouillet, Julien Flament
Huntington's disease is an inherited disorder characterized by psychiatric, cognitive, and motor symptoms due to degeneration of medium spiny neurons in the striatum. A prodromal phase precedes the onset, lasting decades. Current biomarkers include clinical score and striatal atrophy using Magnetic Resonance Imaging (MRI). These markers lack sensitivity for subtle cellular changes during the prodromal phase. MRI and MR spectroscopy offer different contrasts for assessing metabolic, microstructural, functional, or vascular alterations in the disease...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38373256/histamine-3-receptor-availability-and-glutamate-levels-in-the-brain-a-pet-1h-mrs-study-of-patients-with-schizophrenia-and-healthy-controls
#7
JOURNAL ARTICLE
Atheeshaan Arumuham, Matthew M Nour, Mattia Veronese, Katherine Beck, Ellis Chika Onwordi, David J Lythgoe, Sameer Jauhar, Eugenii A Rabiner, Oliver D Howes
BACKGROUND: The histamine-3 receptor (H3R) may have a role in cognitive processes, through its action as a presynaptic heteroreceptor inhibiting the release of glutamate in the brain. To explore this, we examined anterior cingulate cortex (ACC) and striatum H3R availability in patients with schizophrenia, and characterised their relationships with glutamate levels in corresponding brain regions. METHODS: We employed a cross-sectional study, recruiting 12 patients with schizophrenia and 12 healthy volunteers...
February 19, 2024: International Journal of Neuropsychopharmacology
https://read.qxmd.com/read/38311073/the-effectiveness-of-vortioxetine-on-neurobiochemical-metabolites-and-cognitive-of-major-depressive-disorders-patients-a-8-week-follow-up-study
#8
JOURNAL ARTICLE
Yiliang Zhang, Shunkai Lai, Jianzhao Zhang, Ying Wang, Hui Zhao, Jiali He, Dong Huang, Guanmao Chen, Zhangzhang Qi, Pan Chen, Shuya Yan, Xiaosi Huang, Xiaodan Lu, Shuming Zhong, Yanbin Jia
OBJECTIVE: Vortioxetine has been shown to improve cognitive performance in people with depression. This study will look at the changes in neurobiochemical metabolites that occur when vortioxetine improves cognitive performance in MDD patients, with the goal of determining the neuroimaging mechanism through which vortioxetine improves cognitive function. METHODS: 30 depressed patients and 30 demographically matched healthy controls (HC) underwent MCCB cognitive assessment and 1H-MRS...
April 15, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38284542/mr-spectroscopy-assessment-of-daily-variations-of-gaba-levels-within-the-parietal-lobe-and-anterior-cingulate-gyrus-regions-of-healthy-young-adults
#9
JOURNAL ARTICLE
Yujie Ye, Zhaomin Zhong, Xiaojuan Wu, Yangyang Tian, Zifan Wei, Shuting Han, Peng Wu, Hui Dai, Lan Shen, Han Wang, Yonggang Li
BACKGROUND: The changes that occur in the gamma-aminobutyric acid (GABA) levels within specific brain regions throughout the day are less clear. PURPOSE: To evaluate the daily fluctuations of GABA levels within the parietal lobe (PL) and anterior cingulate gyrus (ACC) regions and explore their association with melatonin (MT) levels, heart rate (HR), and blood pressure. STUDY TYPE: Prospective. SUBJECTS: 26 healthy young adults (15 males and 11 females aged 22-27 years)...
January 29, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38263948/3t-31-p-1-h-calf-muscle-coil-for-1-h-and-31-p-mri-mrs-integrated-with-nirs-data-acquisition
#10
JOURNAL ARTICLE
Bei Zhang, Daniel Lowrance, Manoj Kumar Sarma, Miles Bartlett, David Zaha, Michael D Nelson, Anke Henning
PURPOSE: Our aim was to design and build a 3T 31 P/1 H calf coil that is capable of providing both good 31 P and 1 H transmit and receive performance, as well as being capable of accommodating a near-infrared spectroscopy (NIRS) device for simultaneous NIRS data and MRI/MRS acquisition. METHOD: In this work, we propose a new 3T 31 P/1 H birdcage combination design consisting of two co-centrically positioned birdcages on the same surface to maximize transmit efficiency and sensitivity for both nuclei...
January 24, 2024: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38249138/proton-magnetic-resonance-spectroscopy-based-evaluation-of-metabolic-abnormalities-in-the-right-dorsolateral-prefrontal-cortex-and-caudate-nucleus-in-treatment-na%C3%A3-ve-patients-with-obsessive-compulsive-disorder
#11
JOURNAL ARTICLE
Gagan Hans, Uma Sharma, Novy Gupte, Ragul Ganesh, Vaibhav Patil, Pratap Sharan
BACKGROUND: Obsessive-compulsive disorder (OCD) is a common psychiatric disorder whose underlying pathophysiology is insufficiently understood. The pathophysiology of OCD may be related to abnormalities in the biochemistry of neurotransmitters. AIM: The aim of the present study was to measure the absolute concentration of various metabolites in the right dorsolateral prefrontal cortex (DLPFC) and caudate nucleus (CN) in treatment-naive patients with OCD and compare it with healthy controls (HCs)...
November 2023: Indian Journal of Psychiatry
https://read.qxmd.com/read/38227598/longitudinal-mri-and-1h-mrs-study-of-sca7-mouse-forebrain-reveals-progressive-multiregional-atrophy-and-early-brain-metabolite-changes-indicating-early-neuronal-and-glial-dysfunction
#12
JOURNAL ARTICLE
Jean-Baptiste Pérot, Anna Niewiadomska-Cimicka, Emmanuel Brouillet, Yvon Trottier, Julien Flament
SpinoCerebellar Ataxia type 7 (SCA7) is an inherited disorder caused by CAG triplet repeats encoding polyglutamine expansion in the ATXN7 protein, which is part of the transcriptional coactivator complex SAGA. The mutation primarily causes neurodegeneration in the cerebellum and retina, as well as several forebrain structures. The SCA7140Q/5Q knock-in mouse model recapitulates key disease features, including loss of vision and motor performance. To characterize the temporal progression of brain degeneration of this model, we performed a longitudinal study spanning from early to late symptomatic stages using high-resolution magnetic resonance imaging (MRI) and in vivo 1H-magnetic resonance spectroscopy (1H-MRS)...
2024: PloS One
https://read.qxmd.com/read/38223456/in-vivo-mrs-study-of-long-term-effects-of-traumatic-intracranial-injection-of-a-culture-medium-in-mice
#13
JOURNAL ARTICLE
O B Shevelev, O P Cherkasova, I A Razumov, E L Zavjalov
Orthotopic transplantation of glioblastoma cells in the brain of laboratory mice is a common animal model for studying brain tumors. It was shown that 1H magnetic resonance spectroscopy (MRS) enables monitoring of the tumor's occurrence and its development during therapy based on the ratio of several metabolites. However, in studying new approaches to the therapy of glioblastoma in the model of orthotopic xenotransplantation of glioma cells into the brain of mice, it is necessary to understand which metabolites are produced by a growing tumor and which are the result of tumor cells injection along the modeling of the pathology...
October 2023: Vavilovskii Zhurnal Genetiki i Selektsii
https://read.qxmd.com/read/38206287/acetaldehyde-mediated-increase-in-glutamatergic-and-n-acetylaspartate-neurometabolite-levels-in-the-midcingulate-cortex-of-aldh2-1-2-heterozygous-young-adults
#14
JOURNAL ARTICLE
Fumihiko Ueno, Mutsuki Sakuma, Shinichiro Nakajima, Sakiko Tsugawa, Ryo Ochi, Hideaki Tani, Yoshihiro Noda, Ariel Graff-Guerrero, Hiroyuki Uchida, Masaru Mimura, Shunji Oshima, Sachio Matsushita
BACKGROUND: To elucidate the neurobiology underlying alcohol's effect on the human brain, we examined the acute effects of moderate alcohol administration on levels of glutamatergic neurometabolites and N-acetylaspartate, an amino acid found in neurons, may reflect disordered neuronal integrity. METHODS: Eighteen healthy Japanese participants (7 males/11 females) aged 20-30 years who were heterozygous for an inactive allele of acetaldehyde dehydrogenase-2 (ALDH/*1/*2) were included...
January 2024: Alcohol Clin Exp Res (Hoboken)
https://read.qxmd.com/read/38156270/reduced-gaba-concentration-in-patients-with-white-matter-hyperintensities
#15
JOURNAL ARTICLE
Xin Wang, Caihong Wang, Peifang Miao, Ying Wei, Liangjie Lin, Zhen Li, Yong Zhang, Jingliang Cheng, Cuiping Ren
To investigate potential alterations of white matter hyperintensities (WMHs) on J -edited MR spectroscopy (MRS) measures of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA). Twenty-four WMHs patients and 20 healthy controls (HCs) were recruited to undergo magnetic resonance spectroscopy (MRS) scan at 3T from voxels in left centrum semiovale white matter, using the MEGA point resolved spectroscopy (MEGA-PRESS) technique with the MATLAB-based Gannet tool to estimate GABA+ co-edited macromolecule (GABA+) levels and using Tarquin software to estimate levels of glutamate + glutamine (Glx), total N-acetylaspartate (tNAA), total choline (tCho), and total creatine (tCr)...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/38137114/cortical-gaba-levels-are-reduced-in-post-acute-covid-19-syndrome
#16
JOURNAL ARTICLE
Ksenija Marinkovic, David R White, Austin Alderson Myers, Katie S Parker, Donatello Arienzo, Graeme F Mason
After recovering from the acute COVID-19 illness, a substantial proportion of people continue experiencing post-acute sequelae of COVID-19 (PASC), also termed "long COVID". Their quality of life is adversely impacted by persistent cognitive dysfunction and affective distress, but the underlying neural mechanisms are poorly understood. The present study recruited a group of mostly young, previously healthy adults (24.4 ± 5.2 years of age) who experienced PASC for almost 6 months following a mild acute COVID-19 illness...
December 1, 2023: Brain Sciences
https://read.qxmd.com/read/38106257/metabolic-heterogeneity-in-different-subtypes-of-malformations-of-cortical-development-causing-epilepsy-a-proton-magnetic-resonance-spectroscopy-study
#17
JOURNAL ARTICLE
Huaxia Pu, Liping Wang, Wenyu Liu, Qiaoyue Tan, Xinyue Wan, Weina Wang, Xiaorui Su, Huaiqiang Sun, Simin Zhang, Qiang Yue, Qiyong Gong
BACKGROUND: The most common subtypes of malformations of cortical development (MCDs) are gray matter heterotopia (GMH), focal cortical dysplasia (FCD), and polymicrogyria (PMG). This study aimed to characterize the possible neurometabolic abnormalities and heterogeneity in different MCDs subtypes using proton magnetic resonance spectroscopy (1 H-MRS). METHODS: In this prospective cross-sectional study, we recruited 29 patients with MCDs and epilepsy, including ten with GMH, ten with FCD, and nine with PMG, as well as 25 age- and sex-matched healthy controls (HC) from the Epilepsy Center of West China Hospital of Sichuan University between August 2018 and November 2021...
December 1, 2023: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38065860/characteristic-early-changes-of-glu-and-cho-in-brain-regions-affected-by-different-types-of-subjective-cognitive-decline-and-their-clinical-significance
#18
JOURNAL ARTICLE
Zhen Zeng, Jing He, Tao Yao
To discuss the early changes of Glu and Cho in the affected areas of different types of subjective cognitive decline, including amnestic MCI (aMCl), non-amnestic MCI (naMCI) and vascular cognitive impairment no dementia (VCIND), using Proton Magnetic Resonance Spectroscopy (1H-MRS) technology. Routine head MRI and lH-MRS examinations were performed on 50 clearly diagnosed aMCI patients, 44 naMCI patients, 44 VCIND patients, and 44 elderly individuals with normal cognitive function. Measure the volume of the patient bilateral hippocampus...
December 8, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38029371/uncertainty-propagation-in-absolute-metabolite-quantification-for-in-vivo-mrs-of-the-human-brain
#19
JOURNAL ARTICLE
Ronald Instrella, Christoph Juchem
PURPOSE: Absolute spectral quantification is the standard method for deriving estimates of the concentration from metabolite signals measured using in vivo proton MRS (1 H-MRS). This method is often reported with minimum variance estimators, specifically the Cramér-Rao lower bound (CRLB) of the metabolite signal amplitude's scaling factor from linear combination modeling. This value serves as a proxy for SD and is commonly reported in MRS experiments. Characterizing the uncertainty of absolute quantification, however, depends on more than simply the CRLB...
November 29, 2023: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38010083/optimization-of-the-flip-angles-of-narrow-band-editing-pulses-in-j-difference-edited-mrs-of-lactate-at-3t
#20
JOURNAL ARTICLE
Jason E Moore, Ryan K Robison, Jie Hu, Saikat T Sengupta, Olaimatu S Mahdi, Adam W Anderson, Leo Y Luo, Alexander C Mohler, Ryan T Merrell, Changho Choi
PURPOSE: Application of highly selective editing RF pulses provides a means of minimizing co-editing of contaminants in J-difference MRS (MEGA), but it causes reduction in editing yield. We examined the flip angles (FAs) of narrow-band editing pulses to maximize the lactate edited signal with minimal co-editing of threonine. METHODS: The effect of editing-pulse FA on the editing performance was examined, with numerical and phantom analyses, for bandwidths of 17...
November 27, 2023: Magnetic Resonance in Medicine
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