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https://www.readbyqxmd.com/read/27915238/pontine-changes-in-metabolites-and-axonal-fibres-of-rats-following-four-week-alcohol-exposure-in-vivo-diffusion-tensor-imaging-and-1h-magnetic-resonance-spectroscopy-study-at-7-0-t
#1
Jianming Luo, Zhiwei Shen, Guang Chen, Dian Wang, Xiaojun Yu
AIMS: We characterized the metabolite content and axonal fibre changes in the rat pontine, in vivo, using (1)H-magnetic resonance spectroscopy (1H-MRS) and diffusion tensor imaging (DTI) with a 7.0 T magnetic resonance imaging (MRI) scanner following chronic alcohol administration to explore new indicators for the early diagnosis and treatment of chronic alcoholism. METHODS: Forty male Sprague-Dawley rats were randomly divided into the EtOH and control groups (water group)...
December 3, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27909683/fronto-striatal-glutamate-in-children-with-tourette-s-disorder-and-attention-deficit-hyperactivity-disorder
#2
Jilly Naaijen, Natalie J Forde, David J Lythgoe, Sophie E A Akkermans, Thaira J C Openneer, Andrea Dietrich, Marcel P Zwiers, Pieter J Hoekstra, Jan K Buitelaar
OBJECTIVE: Both Tourette's disorder (TD) and attention-deficit/hyperactivity disorder (ADHD) have been related to abnormalities in glutamatergic neurochemistry in the fronto-striatal circuitry. TD and ADHD often co-occur and the neural underpinnings of this co-occurrence have been insufficiently investigated in prior studies. METHOD: We used proton magnetic resonance spectroscopy (1H-MRS) in children between 8 and 12 years of age (TD n = 15, ADHD n = 39, TD + ADHD n = 29, and healthy controls n = 53) as an in vivo method of evaluating glutamate concentrations in the fronto-striatal circuit...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27902528/increased-brain-lactate-during-depressive-episodes-and-reversal-effects-by-lithium-monotherapy-in-drug-naive-bipolar-disorder-a-3-t-1h-mrs-study
#3
Rodrigo Machado-Vieira, Marcus V Zanetti, Maria C Otaduy, Rafael T De Sousa, Marcio G Soeiro-de-Souza, Alana C Costa, Andre F Carvalho, Claudia C Leite, Geraldo F Busatto, Carlos A Zarate, Wagner F Gattaz
OBJECTIVE: Mitochondrial dysfunction and energy metabolism impairment are key components in the pathophysiology of bipolar disorder (BD) and may involve a shift from aerobic to anaerobic metabolism. Measurement of brain lactate in vivo using proton magnetic resonance spectroscopy (H-MRS) represents an important tool to evaluate mitochondrial and metabolic dysfunction during mood episodes, as well as to monitor treatment response. To date, very few studies have quantified brain lactate in BD...
November 28, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27889838/changes-of-brain-metabolite-concentrations-during-maturation-in-different-brain-regions-measured-by-chemical-shift-imaging
#4
Eva Bültmann, Thomas Nägele, Heinrich Lanfermann, Uwe Klose
INTRODUCTION: We examined the effect of maturation on the regional distribution of brain metabolite concentrations using multivoxel chemical shift imaging. METHODS: From our pool of pediatric MRI examinations, we retrospectively selected patients showing a normal cerebral MRI scan or no pathologic signal abnormalities at the level of the two-dimensional 1H MRS-CSI sequence and an age-appropriate global neurological development, except for focal neurological deficits...
November 26, 2016: Neuroradiology
https://www.readbyqxmd.com/read/27889757/morphological-and-metabolic-alteration-of-cerebellum-in-patients-with-post-stroke-depression
#5
Ling Zhang, Rubo Sui, Lei Zhang, Zhuang Zhang
BACKGROUND: To study morphological and metabolic changes of cerebellum with multimodality magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS), respective, to explore correlation between cerebellum alteration and severity of depression in patients with post-stroke depression. METHODS: 60 subjects, including 40 stroke patients and 20 healthy volunteers were enrolled. Depression of stroke patients was tested by Self-rating Depression Scale (SDS) and Hamilton Depression Scale (HAMD), based on which stroke-patients were grouped into post-stroke depression (PSD group) and without post-stroke depression (CONT group)...
November 25, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27869141/fronto-striatal-glutamate-in-autism-spectrum-disorder-and-obsessive-compulsive-disorder
#6
Jilly Naaijen, Marcel P Zwiers, Houshang Amiri, Steven Cr Williams, Sarah Durston, Bob Oranje, Daniel Brandeis, Regina Boecker-Schlier, Matthias Ruf, Isabella Wolf, Tobias Banaschewski, Jeffrey C Glennon, Barbara Franke, Jan K Buitelaar, David J Lythgoe
Autism spectrum disorders (ASD) and obsessive compulsive disorder (OCD) are often comorbid with the overlap based on compulsive behaviors. Although previous studies suggest glutamatergic deficits in fronto-striatal brain areas in both disorders, this is the first study to directly compare the glutamate concentrations across the two disorders with those in healthy control participants using both categorical and dimensional approaches. In the current multi-center study (four centers), we used proton magnetic resonance spectroscopy (1H MRS) in 51 children with ASD, 29 with OCD, and 53 healthy controls (aged 8 to 13 years) to investigate glutamate (Glu) concentrations in two regions of the fronto-striatal circuit: midline anterior cingulate cortex (ACC) and left dorsal striatum...
November 21, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27847932/neurochemical-alterations-in-anterior-cingulate-cortex-in-bipolar-disorder-a-proton-magnetic-resonance-spectroscopy-study-1h-mrs
#7
Beata Galińska-Skok, Beata Konarzewska, Bożena Kubas, Eugeniusz Tarasów, Agata Szulc
OBJECTIVES: The aim of this study was to determine neurochemical alterations in bipolar disorder using proton magnetic resonance spectroscopy (1H-MRS). METHODS: We investigated a group of 27 patients diagnosed with bipolar disorder (with manic and mixed episodes, depression and after remission of symptoms) and 10 healthy subjects. MR imaging and 1H-MRS were performed on a 1.5 T scanner. Voxels of 8 cm3 were positioned in the anterior cingulate, left frontal lobe and left temporal lobe...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27832096/mr-spectroscopy-in-prostate-cancer-new-algorithms-to-optimize-metabolite-quantification
#8
Giovanni Bellomo, Francesco Marcocci, David Bianchini, Emilio Mezzenga, Vincenzo D'Errico, Enrico Menghi, Romano Zannoli, Anna Sarnelli
Prostate cancer (PCa) is the most common non-cutaneous cancer in male subjects and the second leading cause of cancer-related death in developed countries. The necessity of a non-invasive technique for the diagnosis of PCa in early stage has grown through years. Proton magnetic resonance spectroscopy (1H-MRS) and proton magnetic resonance spectroscopy imaging (1H-MRSI) are advanced magnetic resonance techniques that can mark the presence of metabolites such as citrate, choline, creatine and polyamines in a selected voxel, or in an array of voxels (in MRSI) inside prostatic tissue...
2016: PloS One
https://www.readbyqxmd.com/read/27772535/1h-magnetic-resonance-spectroscopy-evidence-for-occipital-involvement-in-treatment-naive-paediatric-obsessive-compulsive-disorder
#9
Maria Ljungberg, Marie K L Nilsson, Karin Melin, Lars Jönsson, Arvid Carlsson, Åsa Carlsson, Eva Forssell-Aronsson, Tord Ivarsson, Maria Carlsson, Göran Starck
OBJECTIVE: Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder leading to considerable distress and disability. Therapies are effective in a majority of paediatric patients, however, many only get partial response. It is therefore important to study the underlying pathophysiology of the disorder. METHODS: 1H magnetic resonance spectroscopy (MRS) was used to study the concentration of brain metabolites in four different locations (cingulate gyrus and sulcus, occipital cortex, thalamus and right caudate nucleus)...
October 24, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27770643/1h-magnetic-resonance-spectroscopy-study-of-glutamate-related-abnormality-in-bipolar-disorder
#10
Hiroko Kubo, Masahito Nakataki, Satsuki Sumitani, Jun-Ichi Iga, Shusuke Numata, Naomi Kameoka, Shin-Ya Watanabe, Hidehiro Umehara, Makoto Kinoshita, Masatoshi Inoshita, Mai Tamaru, Masashi Ohta, Chiaki Nakayama-Yamauchi, Yasuhiro Funakoshi, Masafumi Harada, Tetsuro Ohmori
BACKGROUND: Previous studies of patients with bipolar disorder (BD) using magnetic resonance spectroscopy (MRS) have shown neurophysiological abnormalities related to the glutamate (Glu)-glutamine (Gln) cycle, membrane turnover, and neuronal integrity, although the results were neither consistent nor conclusive. Recently it has been reported the Gln/Glu ratio is the most useful index, quantifying neuronal-glial interactions and the balance of glutamatergic metabolites In this MRS study, we elucidated the abnormalities of metabolites in a larger sample of patients with BD with a high-field MRI system...
October 8, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27748207/metabolic-abnormality-in-the-right-dorsolateral-prefrontal-cortex-in-patients-with-obsessive-compulsive-disorder-proton-magnetic-resonance-spectroscopy
#11
Shin-Eui Park, Nam-Gil Choi, Gwang-Woo Jeong
OBJECTIVE: Proton magnetic resonance spectroscopy (1H-MRS) was used to evaluate metabolic changes in the dorsolateral prefrontal cortex (DLPFC) in patients with obsessive-compulsive disorder (OCD). METHODS: In total, 14 OCD patients (mean age 28.9±7.2 years) and 14 healthy controls (mean age 32.6±7.1 years) with no history of neurological and psychiatric illness participated in this study. Brain metabolite concentrations were measured from a localised voxel on the right DLPFC using a 3-Tesla 1H-MRS...
October 17, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27695638/frontal-metabolite-concentration-deficits-in-opiate-dependence-relate-to-substance-use-cognition-and-self-regulation
#12
Donna E Murray, Timothy C Durazzo, Thomas P Schmidt, Christoph Abé, Joseph Guydish, Dieter J Meyerhoff
OBJECTIVE: Proton magnetic resonance spectroscopy (1H MRS) in opiate dependence showed abnormalities in neuronal viability and glutamate concentration in the anterior cingulate cortex (ACC). Metabolite levels in dorsolateral prefrontal cortex (DLPFC) or orbitofrontal cortex (OFC) and their neuropsychological correlates have not been investigated in opiate dependence. METHODS: Single-volume proton MRS at 4 Tesla and neuropsychological testing were conducted in 21 opiate-dependent individuals (OD) on buprenorphine maintenance therapy...
August 2016: Journal of Addiction Research & Therapy
https://www.readbyqxmd.com/read/27631243/in-vivo-neurometabolic-profiling-in-orthostatic-tremor
#13
Julián Benito-León, Elan D Louis, Virginia Mato-Abad, Ulrike Dydak, Juan Álvarez-Linera, Juan Antonio Hernández-Tamames, José Antonio Molina-Arjona, Norberto Malpica, Michele Matarazzo, Juan Pablo Romero, Álvaro Sánchez-Ferro
The pathogenesis of orthostatic tremor (OT) remains unclear, although some evidence points to dysfunction in the brainstem or cerebellum. We used single voxel proton magnetic resonance spectroscopy (1H-MRS) (3 T) to investigate whether neurochemical changes underlie abnormal cerebellar or cortical function in OT. Fourteen OT patients and 14 healthy controls underwent 1H-MRS studies with voxels placed in midparietal gray matter and cerebellum (vermis and central white matter). Spectral analysis was analyzed using the software package LCModel (version 6...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27587950/in-vivo-proton-magnetic-resonance-spectroscopy-of-2-hydroxyglutarate-in-isocitrate-dehydrogenase-mutated-gliomas-a-technical-review-for-neuroradiologists
#14
REVIEW
Hyeonjin Kim, Sungjin Kim, Hyeong Hun Lee, Hwon Heo
The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently. However, due to severe spectral overlap with background signals, quantification of 2HG can be very challenging. In this technical review for neuroradiologists, first, the biochemistry of 2HG and its significance in the diagnosis of IDH-MT gliomas are summarized...
September 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27579785/influence-of-ethnicity-on-the-accuracy-of-non-invasive-scores-predicting-non-alcoholic-fatty-liver-disease
#15
Ming-Feng Xia, Hannele Yki-Järvinen, Hua Bian, Huan-Dong Lin, Hong-Mei Yan, Xin-Xia Chang, You Zhou, Xin Gao
OBJECTIVES: Presence of non-alcoholic fatty liver disease (NAFLD) can predict risks for diabetes, cardiovascular disease and advanced liver disease in the general population. We aimed to establish a non-invasive score for prediction of NAFLD in Han Chinese, the largest ethnic group in the world, and detect whether ethnicity influences the accuracy of such a score. METHODS: Liver fat content (LFAT) was measured by quantitative ultrasound in 3548 subjects in the Shanghai Changfeng Community and a Chinese score was created using multivariate logistic regression analyses...
2016: PloS One
https://www.readbyqxmd.com/read/27562377/altered-glutamate-and-regional-cerebral-blood-flow-levels-in-schizophrenia-a-1-h-mrs-and-pcasl-study
#16
S Andrea Wijtenburg, Susan N Wright, Stephanie A Korenic, Frank E Gaston, Nkemdilim Ndubuizu, Joshua Chiappelli, Robert P McMahon, Hongji Chen, Anya Savransky, Xiaoming Du, Danny J J Wang, Peter Kochunov, L Elliot Hong, Laura M Rowland
The neurobiology of schizophrenia (SZ) may be altered in older versus younger adults with SZ, as less frequent episodes of symptom exacerbation and increased sensitivity to medications are observed in older age. The goal of this study was to examine the effect of age and diagnosis on glutamate and cerebral blood flow (rCBF) in adults with SZ and healthy controls. Young and older adults with SZ and healthy controls were recruited to participate in this study. Participants completed a neuropsychological battery and neuroimaging that included optimized magnetic resonance spectroscopy to measure anterior cingulate (AC) glutamate (Glu) and glutamine (Gln) and arterial spin labeling evaluation for rCBF...
October 5, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27549605/can-neuroimaging-provide-reliable-biomarkers-for-obsessive-compulsive-disorder-a-narrative-review
#17
REVIEW
Ilana Frydman, Juliana B de Salles Andrade, Paula Vigne, Leonardo F Fontenelle
In this integrative review, we discuss findings supporting the use neuroimaging biomarkers in the diagnosis and treatment of obsessive-compulsive disorder (OCD). To do so, we have selected the most recent studies that attempted to identify the underlying pathogenic process associated with OCD and whether they provide useful information to predict clinical features, natural history or treatment responses. Studies using functional magnetic resonance (fMRI), voxel-based morphometry (VBM), diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in OCD patients are generally supportive of an expanded version of the earlier cortico-striatal-thalamus-cortical (CSTC) model of OCD...
October 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27547969/creatine-glutamine-plus-glutamate-and-macromolecules-are-decreased-in-the-central-white-matter-of-premature-neonates-around-term
#18
Meriam Koob, Angèle Viola, Yann Le Fur, Patrick Viout, Hélène Ratiney, Sylviane Confort-Gouny, Patrick J Cozzone, Nadine Girard
Preterm birth represents a high risk of neurodevelopmental disabilities when associated with white-matter damage. Recent studies have reported cognitive deficits in children born preterm without brain injury on MRI at term-equivalent age. Understanding the microstructural and metabolic underpinnings of these deficits is essential for their early detection. Here, we used diffusion-weighted imaging and single-voxel 1H magnetic resonance spectroscopy (MRS) to compare brain maturation at term-equivalent age in premature neonates with no evidence of white matter injury on conventional MRI except diffuse excessive high-signal intensity, and normal term neonates...
2016: PloS One
https://www.readbyqxmd.com/read/27513267/1h-magnetic-resonance-spectroscopy-in-first-episode-and-chronic-schizophrenia-patients
#19
Duygu Kirtaş, Rukiye Filiz Karadağ, Melike Ceyhan Balci Şengül, Yılmaz Kiroğlu
BACKGROUND/AIM: The aim of this study was to compare metabolite levels of the dorsolateral prefrontal cortex (DLPFC), anterior cingulate gyrus (ACG), thalamus, and hippocampus in patients with chronic schizophrenia (CSPs) and first psychotic episode patients (FEPs) by the use of magnetic resonance spectroscopy (MRS). MATERIALS AND METHODS: Thirty CSPs, 20 FEPs, and 30 healthy subjects participated in this study. N-Acetylaspartate (NAA), creatine, choline (Cho), and myoinositol levels of the DLPFC, ACG, thalamus, and hippocampus were measured by 1H-MRS...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27502517/therapeutic-prospective-of-infused-allogenic-cultured-mesenchymal-stem-cells-in-traumatic-brain-injury-mice-a-longitudinal-proton-magnetic-resonance-spectroscopy-assessment
#20
Sushanta Kumar Mishra, Poonam Rana, Subash Khushu, Gurudutta Gangenahalli
: : Improved therapeutic assessment of experimental traumatic brain injury (TBI), using mesenchymal stem cells (MSCs), would immensely benefit its therapeutic management. Neurometabolite patterns at injury site, measured with proton magnetic resonance spectroscopy (1H-MRS) after MSCs transplantation, may serve as a bio-indicator of the recovery mechanism. This study used in vivo magnetic resonance imaging and 1H-MRS to evaluate the therapeutic prospects of implanted MSCs at injury site in experimental mice longitudinally up to 21 days...
August 8, 2016: Stem Cells Translational Medicine
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