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1H-MRS

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https://www.readbyqxmd.com/read/29748628/7t-1-h-mrs-in-major-depressive-disorder-a-ketamine-treatment-study
#1
Jennifer W Evans, Níall Lally, Li An, Ningzhi Li, Allison C Nugent, Dipavo Banerjee, Sam L Snider, Jun Shen, Jonathan P Roiser, Carlos A Zarate
The glutamatergic modulator ketamine has striking and rapid antidepressant effects in major depressive disorder (MDD), but its mechanism of action remains unknown. Proton magnetic resonance spectroscopy (1H-MRS) is the only non-invasive method able to directly measure glutamate levels in vivo; in particular, glutamate and glutamine metabolite concentrations are separable by 1H-MRS at 7T. This double-blind, placebo-controlled, crossover study that included 1 H-MRS scans at baseline and at 24 h post ketamine and post-placebo infusions sought to determine glutamate levels in the pregenual anterior cingulate (pgACC) of 20 medication-free MDD subjects and 17 healthy volunteers (HVs) 24 h post ketamine administration, and to evaluate any other measured metabolite changes, correlates, or predictors of antidepressant response...
April 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29728816/quantitative-mr-spectroscopy-reveals-metabolic-changes-in-the-dorsolateral-prefrontal-cortex-of-patients-with-temporal-lobe-epilepsy
#2
Qiaoyue Tan, Huaiqiang Sun, Weina Wang, Xintong Wu, Nanya Hao, Xiaorui Su, Xibiao Yang, Simin Zhang, Jingkai Su, Qiang Yue, Qiyong Gong
OBJECTIVE: To characterize possible metabolic changes of the dorsolateral prefrontal cortex (DLPFC) in patients with temporal lobe epilepsy (TLE). METHODS: Quantitative proton magnetic resonance spectroscopy (1H-MRS) studies were performed on 24 TLE patients and 22 healthy controls. Metabolite concentrations were calculated using a linear combination model (LCModel) and corrected for cerebrospinal fluid contamination. Comparisons were performed between the TLE patients and the controls and between the left DLPFC and right DLPFC in each group...
May 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29718334/low-dose-levothyroxine-reduces-intrahepatic-lipid-content-in-patients-with-type-2-diabetes-mellitus-and-nafld
#3
Eveline Bruinstroop, Rinkoo Dalan, Cao Yang, Yong Mong Bee, Kurumbian Chandran, Li Wei Cho, Shui Boon Soh, Eng Kiong Teo, Sue-Anne Toh, Melvin Khee Shing Leow, Rohit A Sinha, Suresh Anand Sadananthan, Navin Michael, Heather Stapleton, Christopher Leung, Peter W Angus, Sheila K Patel, Louise M Burrell, Lim Su Chi, Sum Chee Fang, S Sendhil Velan, Paul M Yen
Context/Objective: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in patients with type 2 diabetes mellitus and associated with significant morbidity and mortality. Thyroid hormone (TH) increases β-oxidation of fatty acids and decreases intrahepatic lipid content (IHLC) in rodents with NAFLD. In this study we investigated the possibility of low intrahepatic TH concentration in NAFLD and studied the effect of TH treatment in humans. Design/Setting: We performed a phase 2b single arm study in six hospitals in Singapore to study whether TH reduced IHLC...
April 27, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29668904/a-whole-brain-longitudinal-study-in-the-yac128-mouse-model-of-huntington-s-disease-shows-distinct-trajectories-of-neurochemical-structural-connectivity-and-volumetric-changes
#4
Lorena I Petrella, João M Castelhano, Mario Ribeiro, José V Sereno, Sónia I Gonçalves, Mário N Laço, Michael R Hayden, Ana C Rego, Miguel Castelo-Branco
Huntington's disease (HD) is a neurodegenerative disorder causing cognitive and motor impairments, evolving to death within 15-20 years after symptom onset. We previously established a mouse model with the entire human HD gene containing 128 CAG repeats (YAC128) which accurately recapitulates the natural history of the human disease. Defined time points in this natural history enable the understanding of longitudinal trajectories from the neurochemical and structural points of view using non-invasive high-resolution multimodal imaging...
April 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29569535/changing-to-a-vegetarian-diet-reduces-the-body-creatine-pool-in-omnivorous-women-but-appears-not-to-affect-carnitine-and-carnosine-homeostasis-a-randomised-trial
#5
Laura Blancquaert, Audrey Baguet, Tine Bex, Anneke Volkaert, Inge Everaert, Joris Delanghe, Mirko Petrovic, Chris Vervaet, Stefaan De Henauw, Dumitru Constantin-Teodosiu, Paul Greenhaff, Wim Derave
Balanced vegetarian diets are popular, although they are nearly absent in creatine and carnosine and contain considerably less carnitine than non-vegetarian diets. Few longitudinal intervention studies investigating the effect of a vegetarian diet on the availability of these compounds currently exist. We aimed to investigate the effect of transiently switching omnivores onto a vegetarian diet for 6 months on muscle and plasma creatine, carnitine and carnosine homeostasis. In a 6-month intervention, forty omnivorous women were ascribed to three groups: continued omnivorous diet (control, n 10), vegetarian diet without supplementation (Veg+Pla, n 15) and vegetarian diet combined with daily β-alanine (0·8-0·4 g/d) and creatine supplementation (1 g creatine monohydrate/d) (Veg+Suppl, n 15)...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29541417/metabolic-profiling-of-the-three-neural-derived-embryonal-pediatric-tumors-retinoblastoma-neuroblastoma-and-medulloblastoma-identifies-distinct-metabolic-profiles
#6
Sarah E Kohe, Christopher D Bennett, Simrandip K Gill, Martin Wilson, Carmel McConville, Andrew C Peet
The rare pediatric embryonal tumors retinoblastoma, medulloblastoma and neuroblastoma derive from neuroectodermal tissue and share similar histopathological features despite different anatomical locations and diverse clinical outcomes. As metabolism can reflect genetic and histological features, we investigated whether the metabolism of embryonal tumors reflects their similar histology, shared developmental and neural origins, or tumor location. We undertook metabolic profiling on 50 retinoblastoma, 39 medulloblastoma and 70 neuroblastoma using high resolution magic angle spinning magnetic resonance spectroscopy (1H-MRS)...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29496988/glutamatergic-biomarkers-for-cocaine-addiction-a-longitudinal-study-in-self-administering-rats-using-mrs-and-mglur5-pet
#7
Bart de Laat, Akila Weerasekera, Gil Leurquin-Sterk, Guy M Bormans, Uwe Himmelreich, Cindy Casteels, Koen Van Laere
Cocaine addiction is a disorder without diagnostic biomarkers or effective pharmacotherapy. Research on the glutamatergic system lacks longitudinal data starting before exposure to cocaine. We present findings in a rat model of cocaine self-administration that was followed-up longitudinally using the mGluR5 tracer 18 F-FPEB PET, 1H-MRS and behavioral tests. Methods: Forty-two Wistar rats were scanned with 18 F-FPEB PET and 1H-MRS before and after sucrose or IV cocaine self-administration, during withdrawal and relapse...
March 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29487562/aripiprazole-selectively-reduces-motor-tics-in-a-young-animal-model-for-tourette-s-syndrome-and-comorbid-attention-deficit-and-hyperactivity-disorder
#8
Francesca Rizzo, Ester Nespoli, Alireza Abaei, Izhar Bar-Gad, Dinesh K Deelchand, Jörg Fegert, Volker Rasche, Bastian Hengerer, Tobias M Boeckers
Tourette's syndrome (TS) is a neurodevelopmental disorder characterized primarily by motor and vocal tics. Comorbidities such as attention deficit and hyperactivity disorder (ADHD) are observed in over 50% of TS patients. We applied aripiprazole in a juvenile rat model that displays motor tics and hyperactivity. We additionally assessed the amount of ultrasonic vocalizations (USVs) as an indicator for the presence of vocal tics and evaluated the changes in the striatal neurometabolism using in vivo proton magnetic resonance spectroscopy (1H-MRS) at 11...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29449141/neurometabolites-alteration-in-the-acute-phase-of-mild-traumatic-brain-injury-mtbi-an-in-vivo-proton-magnetic-resonance-spectroscopy-1h-mrs-study
#9
Vigneswaran Veeramuthu, Pohchoo Seow, Vairavan Narayanan, Jeannie Hsiu Ding Wong, Li Kuo Tan, Aditya Tri Hernowo, Norlisah Ramli
RATIONALE AND OBJECTIVES: Magnetic resonance spectroscopy is a noninvasive imaging technique that allows for reliable assessment of microscopic changes in brain cytoarchitecture, neuronal injuries, and neurochemical changes resultant from traumatic insults. We aimed to evaluate the acute alteration of neurometabolites in complicated and uncomplicated mild traumatic brain injury (mTBI) patients in comparison to control subjects using proton magnetic resonance spectroscopy (1H magnetic resonance spectroscopy)...
February 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29444252/human-striatal-response-to-reward-anticipation-linked-to-hippocampal-glutamate-levels
#10
Matthijs G Bossong, Robin Wilson, Elizabeth Appiah-Kusi, Philip McGuire, Sagnik Bhattacharyya
Background: Dysfunctional reward processing is associated with a number of psychiatric disorders, such as addiction and schizophrenia. It is thought that reward is regulated mainly by dopamine transmission in the ventral striatum. Contemporary animal models suggest that striatal dopamine concentrations and associated behaviours are related to glutamatergic functioning in the ventral hippocampus. However, in humans the association between reward-related ventral striatal response and hippocampal glutamate levels is unclear...
February 10, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29430218/metabolomic-characterization-of-experimental-ovarian-cancer-ascitic-fluid
#11
Santosh K Bharti, Flonné Wildes, Chien-Fu Hung, T C Wu, Zaver M Bhujwalla, Marie-France Penet
Introduction: Malignant ascites (MA) is a major cause of morbidity that occurs in 37% of ovarian cancer patients. The accumulation of MA in the peritoneal cavity due to cancer results in debilitating symptoms and extremely poor quality of life. There is an urgent unmet need to expand the understanding of MA to design effective treatment strategies, and to improve MA diagnosis. Objective: Our purpose here is to contribute to a better characterization of MA metabolic composition in ovarian cancer...
October 2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/29426847/compositional-marker-in-vivo-reveals-intramyocellular-lipid-turnover-during-fasting-induced-lipolysis
#12
Ajay Thankamony, Graham J Kemp, Albert Koulman, Vlada Bokii, David B Savage, Chris Boesch, Leanne Hodson, David B Dunger, Alison Sleigh
Intramyocellular lipid (IMCL) is of particular metabolic interest, but despite many proton magnetic resonance spectroscopy (1 H MRS) studies reporting IMCL content measured by the methylene (CH2 ) resonance signal, little is known about its composition. Here we validated IMCL CH3 :CH2 ratio as a compositional marker using 1 H MRS at short echo time, and investigated IMCL content and composition during a 28-hour fast in 24 healthy males. Increases in IMCL CH2 relative to the creatine and phosphocreatine resonance (Cr) at 3...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29421322/differences-in-steady-state-glutamate-levels-and-variability-between-non-task-active-conditions-evidence-from-1-h-fmrs-of-the-prefrontal-cortex
#13
Jonathan Lynn, Eric A Woodcock, Chaitali Anand, Dalal Khatib, Jeffrey A Stanley
Proton functional magnetic resonance spectroscopy (1 H fMRS) is a noninvasive neuroimaging technique capable of detecting dynamic changes in glutamate related to task-related demands at a temporal resolution under 1 min. Several recent 1 H fMRS studies demonstrated elevated steady-state levels of glutamate of 2% or greater during different 'task-active' conditions, relative to a 'non-task-active' control condition. However, the 'control' condition from these studies does vary with respect to the degree of constraining behavior, which may lead to different glutamate levels or variability between 'control' conditions...
May 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29414127/striatal-neurometabolite-levels-in-patients-with-schizophrenia-undergoing-long-term-antipsychotic-treatment-a-proton-magnetic-resonance-spectroscopy-and-reliability-study
#14
Eric Plitman, Sofia Chavez, Shinichiro Nakajima, Yusuke Iwata, Jun Ku Chung, Fernando Caravaggio, Julia Kim, Youssef Alshehri, M Mallar Chakravarty, Vincenzo De Luca, Gary Remington, Philip Gerretsen, Ariel Graff-Guerrero
Previous proton magnetic resonance spectroscopy (1 H-MRS) studies have reported disrupted levels of various neurometabolites in patients with schizophrenia. An area of particular interest within this patient population is the striatum, which is highly implicated in the pathophysiology of schizophrenia. The present study examined neurometabolite levels in the striatum of 12 patients with schizophrenia receiving antipsychotic treatment for at least 1 year and 11 healthy controls using 3-Tesla 1 H-MRS (PRESS, TE = 35 ms)...
March 30, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29414126/proton-magnetic-resonance-spectroscopy-changes-after-lithium-treatment-systematic-review
#15
REVIEW
Agata Szulc, Magdalena Wiedlocha, Napoleon Waszkiewicz, Beata Galińska-Skok, Piotr Marcinowicz, Jacek Gierus, Anna Mosiolek
1H MRS is widely used in the research of mental disorders. It enables evaluation of concentration or ratios of several metabolites, which play important roles in brain metabolism: N-acetylaspartate (NAA), choline containing compounds, myo-inositol and glutamate, glutamine and GABA (together as Glx complex or separately). Specifically in bipolar disorder brain metabolite abnormalities include mostly NAA reduces and Glx increases in different brain regions. Bipolar disorder is associated with impairment in neurotrophic and cellular plasticity, resilience pathways and in neuroprotective processes...
March 30, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29407539/a-pilot-study-of-minocycline-for-the-treatment-of-bipolar-depression-effects-on-cortical-glutathione-and-oxidative-stress-in-vivo
#16
James W Murrough, Kathryn M Huryk, Xiangling Mao, Brian Iacoviello, Katherine Collins, Andrew A Nierenberg, Guoxin Kang, Dikoma C Shungu, Dan V Iosifescu
BACKGROUND: The antibiotic minocycline appears to promote neuroprotection through antioxidant and other mechanisms that may be relevant to the pathophysiology of bipolar disorder. The present study assessed the efficacy of minocycline in bipolar depression and examined the association between minocycline treatment and brain glutathione (GSH), an essential regulator of oxidative stress. METHOD: Twenty patients with bipolar disorder experiencing acute depressive symptoms enrolled in an 8-week, open-label trial of adjuvant minocycline...
April 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29401483/alcohol-consumption-but-not-smoking-is-associated-with-higher-mr-derived-liver-fat-in-an-asymptomatic-study-population
#17
Christian Bayerl, Roberto Lorbeer, Margit Heier, Christa Meisinger, Susanne Rospleszcz, Anina Schafnitzel, Hannah Patscheider, Sigrid Auweter, Annette Peters, Birgit Ertl-Wagner, Maximilian Reiser, Fabian Bamberg, Holger Hetterich
BACKGROUND: The aim of our study was to determine the relation of alcohol consumption and cigarette smoking on continuous-measured hepatic fat fraction (HFF) in a population free of cardiovascular disease. We suggested a direct correlation of alcohol consumption with HFF and increased HFF in former smokers compared to current smokers. METHODS: Data from 384 subjects (mean age: 56 years, 58% men) of a population-based cohort study (KORA) were included in a cross-sectional design...
2018: PloS One
https://www.readbyqxmd.com/read/29400109/evolution-of-the-neurochemical-profiles-in-the-g93a-sod1-mouse-model-of-amyotrophic-lateral-sclerosis
#18
Hongxia Lei, Elisabeth Dirren, Carole Poitry-Yamate, Bernard L Schneider, Rolf Gruetter, Patrick Aebischer
In vivo 1 H magnetic resonance spectroscopy (1 H-MRS) investigations of amyotrophic lateral sclerosis (ALS) mouse brain may provide neurochemical profiles and alterations in association with ALS disease progression. We aimed to longitudinally follow neurochemical evolutions of striatum, brainstem and motor cortex of mice transgenic for G93A mutant human superoxide dismutase type-1 (G93A-SOD1), an ALS model. Region-specific neurochemical alterations were detected in asymptomatic G93A-SOD1 mice, particularly in lactate (-19%) and glutamate (+8%) of brainstem, along with γ-amino-butyric acid (-30%), N-acetyl-aspartate (-5%) and ascorbate (+51%) of motor cortex...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29390267/rehabilitation-program-based-on-sensorimotor-recovery-improves-the-static-and-dynamic-balance-and-modifies-the-basal-ganglia-neurochemistry-a-pilot-1h-mrs-study-on-parkinson-s-disease-patients
#19
Stefano Delli Pizzi, Rosa Grazia Bellomo, Simona Maria Carmignano, Emilio Ancona, Raffaella Franciotti, Marco Supplizi, Giovanni Barassi, Marco Onofrj, Laura Bonanni, Raoul Saggini
Rehabilitation interventions represent an alternative strategy to pharmacological treatment in order to slow or reverse some functional aspects of disability in Parkinson's disease (PD). To date, the neurophysiological mechanisms underlying rehabilitation-mediated improvement in PD patients are still poorly understood. Interestingly, growing evidence has highlighted a key role of the glutamate in neurogenesis and brain plasticity. The brain levels of glutamate, and of its precursor glutamine, can be detected in vivo and noninvasively as "Glx" by means of proton magnetic resonance spectroscopy (H-MRS)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29368979/beyond-static-measures-a-review-of-functional-magnetic-resonance-spectroscopy-and-its-potential-to-investigate-dynamic-glutamatergic-abnormalities-in-schizophrenia
#20
Luke A Jelen, Sinead King, Paul G Mullins, James M Stone
Abnormalities of the glutamate system are increasingly implicated in schizophrenia but their exact nature remains unknown. Proton magnetic resonance spectroscopy (1H-MRS), while fundamental in revealing glutamatergic alterations in schizophrenia, has, until recently, been significantly limited and thought to only provide static measures. Functional magnetic resonance spectroscopy (fMRS), which uses sequential scans for dynamic measurement of a range of brain metabolites in activated brain areas, has lately been applied to a variety of task or stimulus conditions, producing interesting insights into neurometabolite responses to neural activation...
January 1, 2018: Journal of Psychopharmacology
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