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1H-MRS

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https://www.readbyqxmd.com/read/28793304/frontal-cortex-myo-inositol-is-associated-with-sleep-and-depression-in-adolescents-a-proton-magnetic-resonance-spectroscopy-study
#1
Anna S Urrila, Antti Hakkarainen, Anu Castaneda, Tiina Paunio, Mauri Marttunen, Nina Lundbom
AIM: This study used proton magnetic resonance spectroscopy (1H MRS) to evaluate the neurochemistry of the frontal cortex in adolescents with symptoms of sleep and depression. METHODS: Nineteen non-medicated adolescent boys (mean age 16.0 years; 9 clinical cases with depression/sleep symptoms and 10 healthy controls) underwent 1H MRS at 3 T. MR spectra were acquired from the anterior cingulate cortex (ACC), the dorsolateral prefrontal cortex, and frontal white matter...
August 10, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28770629/ipragliflozin-a-sodium-glucose-co-transporter-2-inhibitor-reduces-intrahepatic-lipid-content-and-abdominal-visceral-fat-volume-in-patients-with-type-2-diabetes
#2
Akio Ohta, Hiroyuki Kato, Satoshi Ishii, Yosuke Sasaki, Yuta Nakamura, Tomoko Nakagawa, Yoshio Nagai, Yasushi Tanaka
OBJECTIVE: We recently investigated the effect of ipragliflozin, a sodium glucose co-transporter-2 inhibitor (SGLT-2I), in Japanese patients with type 2 diabetes by a 24-week. SGLT-2Is also have an anti-obesity effect, and reduction of body fat has been demonstrated by indirect methods. However, evaluation of the effect on the total visceral fat volume and intrahepatic lipid content has not been performed. RESEARCH DESIGN AND METHODS: We measured the abdominal subcutaneous fat volume (SFV) and visceral fat volume (VFV) by whole abdominal CT scanning, the intrahepatic lipid (IHL) content by proton magnetic resonance spectroscopy (1H-MRS), and the fat mass index (FI) and appendicular skeletal mass index (ASMI) by dual X-ray absorptiometry (DXA) in 20 patients from our previous study...
August 3, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28694162/impaired-bone-strength-estimates-at-the-distal-tibia-and-its-determinants-in-adolescents-with-anorexia-nervosa
#3
Vibha Singhal, Shreya S Tulsiani, Karen Joanie Campoverde, Deborah M Mitchell, Meghan Slattery, Melanie Schorr, Karen K Miller, Miriam A Bredella, Madhusmita Misra, Anne Klibanski
BACKGROUND: Altered bone microarchitecture and higher marrow adipose tissue (MAT) may reduce bone strength. High resolution pQCT (HRpQCT) allows assessment of volumetric BMD (vBMD), and size and microarchitecture parameters of bone, while 1H-magnetic resonance spectroscopy (1H-MRS) allows MAT evaluation. We have reported impaired microarchitecture at the non-weight bearing radius in adolescents with anorexia nervosa (AN) and that these changes may precede aBMD deficits. Data are lacking regarding effects of AN on microarchitecture and strength at the weight-bearing tibia in adolescents and young adults, and the impact of changes in microarchitecture and MAT on strength estimates...
July 7, 2017: Bone
https://www.readbyqxmd.com/read/28634390/increased-glutamate-in-somatosensory-cortex-in-functional-dyspepsia
#4
Arthur D P Mak, Georg Northoff, David K W Yeung, Winnie C W Chu, Steve C N Hui, Cynthia Cheung, Jessica Ching, Linda Lam, Sing Lee, Justin Wu
Functional Dyspepsia-Post-prandial Distress Syndrome (FD-PDS) was associated with mood-related increases in resting activity and lowered activation threshold in the somatosensory cortex (SSC), insula and perigenual anterior cingulate cortex(pgACC) in functional imaging studies. The underlying cortical neurochemical changes are unknown. We performed proton Magnetic Resonance Spectroscopy (1H-MRS) on 17 consecutive tertiary clinic-recruited psychotropic-naïve Rome III FD-PDS female and 17 age-sex matched healthy controls...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633367/cortical-glutamate-in-migraine
#5
Ronald Zielman, Jannie P Wijnen, Andrew Webb, Gerrit L J Onderwater, Itamar Ronen, Michel D Ferrari, Hermien E Kan, Gisela M Terwindt, Mark C Kruit
Cortical hyperexcitability due to enhanced glutamatergic activity has been implicated in migraine pathophysiology but direct evidence is lacking. Here we assessed glutamate levels and intracellular mobility of glutamate in the visual cortex of migraineurs in-between attacks. We included 50 migraineurs (23 with aura and 27 without aura) and 24 age- and gender-matched non-headache controls. We used proton magnetic resonance spectroscopy (1H-MRS) and diffusion weighted spectroscopy at 7 T with a single volume of interest (2 × 2 × 3 cm) located in the primary and secondary visual cortex...
July 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28629281/noninvasive-quantitative-assessment-of-hepatic-steatosis-by-proton-magnetic-resonance-spectroscopy-among-adult-patients-receiving-home-parenteral-nutrition
#6
Angelique Huijbers, Geert Wanten, Helena Maria Dekker, Marinette van der Graaf
BACKGROUND: Intestinal failure-associated liver disease is a frequent complication in patients with chronic intestinal failure (CIF), with steatosis as a dominant feature in adults. Proton magnetic resonance spectroscopy (1H-MRS) is a noninvasive method to quantify liver fat content (LFC). In this study, LFC was assessed with 1H-MRS, taking into account the possible accumulation of paramagnetic components of home parenteral nutrition (HPN) that may disturb these measurements. METHODS: LFC was measured in 15 adult CIF patients who had been receiving HPN for >6 months...
June 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28575232/liver-safety-of-statins-in-prediabetes-or-t2dm-and-nonalcoholic-steatohepatitis-post-hoc-analysis-of-a-randomized-trial
#7
Fernando Bril, Paola Portillo Sanchez, Romina Lomonaco, Beverly Orsak, Joan Hecht, Fermin Tio, Kenneth Cusi
Context: Patients with NAFLD have a high cardiovascular risk, but statins are rarely prescribed due to fear of hepatotoxicity. Objective: To perform a prospective assessment of the long-term safety of statins in patients with prediabetes/T2DM and NASH. Design: Post-hoc analysis of statin use during a randomized, controlled trial (RCT) assessing pioglitazone vs. placebo in patients with NASH. Patients: A total of 101 subjects (86 on statins) with biopsy-proven NASH and prediabetes/T2DM were followed for up to 36 months...
June 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28534874/shifting-brain-inhibitory-balance-and-connectivity-of-the-prefrontal-cortex-of-adults-with-autism-spectrum-disorder
#8
L A Ajram, J Horder, M A Mendez, A Galanopoulos, L P Brennan, R H Wichers, D M Robertson, C M Murphy, J Zinkstok, G Ivin, M Heasman, D Meek, M D Tricklebank, G J Barker, D J Lythgoe, R A E Edden, S C Williams, D G M Murphy, G M McAlonan
Currently, there are no effective pharmacologic treatments for the core symptoms of autism spectrum disorder (ASD). There is, nevertheless, potential for progress. For example, recent evidence suggests that the excitatory (E) glutamate and inhibitory (I) GABA systems may be altered in ASD. However, no prior studies of ASD have examined the 'responsivity' of the E-I system to pharmacologic challenge; or whether E-I modulation alters abnormalities in functional connectivity of brain regions implicated in the disorder...
May 23, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28498852/ultra-high-field-7tesla-magnetic-resonance-spectroscopy-in-amyotrophic-lateral-sclerosis
#9
Nazem Atassi, Maosheng Xu, Christina Triantafyllou, Boris Keil, Robert Lawson, Paul Cernasov, Elena Ratti, Christopher J Long, Sabrina Paganoni, Alyssa Murphy, Nouha Salibi, Ravi Seethamraju, Bruce Rosen, Eva-Maria Ratai
The main objective of this study was to utilize high field (7T) in vivo proton magnetic resonance imaging to increase the ability to detect metabolite changes in people with ALS, specifically, to quantify levels of glutamine and glutamine separately. The second objective of this study was to correlate metabolic markers with clinical outcomes of disease progression. 13 ALS participants and 12 age-matched healthy controls (HC) underwent 7 Tesla MRI and MRS. Single voxel MR spectra were acquired from the left precentral gyrus using a very short echo time (TE = 5 ms) STEAM sequence...
2017: PloS One
https://www.readbyqxmd.com/read/28494456/proton-magnetic-resonance-spectroscopy-study-on-the-metabolism-changes-of-cerebellum-in-patients-with-post-stroke-depression
#10
Lei Zhang, Ru-Bo Sui
OBJECTIVE: To study the metabolic changes of cerebellum by proton magnetic resonance Spectroscopy (1H-MRS) and discuss the relationships between the cerebellar changes and depression severity in patients with post-stroke depression. METHODS AND RESULTS: Data of demographic characteristics, individual history and life style of all subjects were collected. 40 patients with stroke and 20 controls were enrolled. All groups received T1WI, T2WI, DWI and 1H-MRS examination...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28445498/metabolic-profiles-by-1h-magnetic-resonance-spectroscopy-in-natalizumab-associated-post-pml-lesions-of-multiple-sclerosis-patients-who-survived-progressive-multifocal-leukoencephalopathy-pml
#11
Ruth Schneider, Barbara Bellenberg, Robert Hoepner, Eva-Maria Kolb, Gisa Ellrichmann, Aiden Haghikia, Ralf Gold, Carsten Lukas
PURPOSE: Early diagnosis and treatment of multiple sclerosis-related progressive multifocal leukoencephalopathy (PML) significantly improve clinical outcomes. However, there is a lack of information regarding the restart of immunomodulatory therapy in the post-PML setting, when multiple sclerosis activity reappears. We aimed at the examination of metabolic differences using 1H-magnetic resonance spectroscopy (1H-MRS) in multiple sclerosis patients at various post-PML stages and at the exploration of differences according to their disease and JC virus (JCV) status...
2017: PloS One
https://www.readbyqxmd.com/read/28431025/1h-magnetic-resonance-spectroscopy-of-live-human-sperm
#12
S Reynolds, S J Calvert, M N Paley, A A Pacey
STUDY QUESTION: Can 1H Magnetic Resonance Spectroscopy (MRS) be used to obtain information about the molecules and metabolites in live human spermatozoa? SUMMARY ANSWER: Percoll-based density gradient centrifugation (DGC) followed by a further two washing steps, yielded enough sperm with minimal contamination (<0.01%) from seminal fluid to permit effective MRS which detected significant differences (p < 0.05) in the choline/glycerophosphocholine, lipid and lactate regions of the 1H MRS spectrum between sperm in the pellet and those from the 40/80% interface...
April 18, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28397726/long-term-brain-tissue-monitoring-after-semi-brain-irradiation-in-rats-using-proton-magnetic-resonance-spectroscopy-a-preliminary-study-in-vivo
#13
Hong Chen, Yu-Shu Cheng, Zheng-Rong Zhou
BACKGROUND: In head and neck neoplasm survivors treated with brain irradiation, metabolic alterations would occur in the radiation-induced injury area. The mechanism of these metabolic alterations has not been fully understood, while the alternations could be sensitively detected by proton (1H) nuclear magnetic resonance spectroscopy (MRS). In this study, we investigated the metabolic characteristics of radiation-induced brain injury through a long-term follow-up after radiation treatment using MRS in vivo...
April 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28368474/human-brown-fat-radiodensity-indicates-underlying-tissue-composition-and-systemic-metabolic-health
#14
Mueez U Din, Juho Raiko, Teemu Saari, Virva Saunavaara, Nobu Kudomi, Olof Solin, Riitta Parkkola, Pirjo Nuutila, Kirsi A Virtanen
Context: Metabolic imaging studying brown adipose tissue (BAT) physiology has increased, where computed tomography (CT) is commonly used as an anatomical reference for metabolic PET (positron emission tomography) imaging. However, the capacity of CT to provide metabolic information has been underexploited. Objective: To evaluate whether CT radiodensity of BAT could non-invasively estimate underlying tissue morphology, regarding amount of stored triglycerides. Further, could the alteration in tissue characteristics due to cold stimulus, as a marker for active BAT, be detected with radiodensity...
March 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28364102/-value-of-1h-mrs-on-sca3-mjd-diagnosis-and-clinical-course
#15
Wu Xing, Xinxin Liao, Tingting Guan, Fangfang Xie, Lu Shen, Weihua Liao, Xiaoyi Wang
To investigate the value of proton magnetic resonance spectroscopy (1H-MRS) on the diagnosis of SCA3/MJD, and to calculate the correlation between 1H-MRS ratio and the clinical score.
 Methods: Sixteen patients with SCA3/MJD and 19 healthy volunteers were scanned with 1H-MRS. The data of N-acetyl aspartate, creatine, choline-containing compounds, myoinositol, NAA/Cr, Cho/Cr, and mI/Cr ratio were collected, which were grouped for comparative study. The onset patients with SCA3/MJD were evaluated with the International Cooperative Ataxia Rating Scale and Scale for the Assessment and Rating of Ataxia, the correlation between NAA/Cr, Cho/Cr or mI/Cr ratio and the clinical score was calculated...
March 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28334548/waist-circumference-is-associated-with-liver-fat-in-black-and-white-adolescents
#16
SoJung Lee, Jennifer L Kuk, Chris Boesch, Silva Arslanian
We examined whether waist circumference (WC) is associated with liver fat in black and white adolescents. Liver fat was measured using a 3T proton magnetic resonance spectroscopy ((1)H-MRS) in 152 overweight/obese adolescents (94 black and 58 white, body mass index (BMI) ≥85th percentile, aged 12-18 years) without liver diseases or diabetes. WC was measured at the last rib. Total and visceral adipose tissue (VAT) were measured by dual-energy X-ray absorptiometry and magnetic resonance imaging, respectively...
March 23, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28323929/human-brown-adipose-tissue-temperature-and-fat-fraction-are-related-to-its-metabolic-activity
#17
Kalle Koskensalo, Juho Raiko, Teemu Saari, Virva Saunavaara, Olli Eskola, Pirjo Nuutila, Jani Saunavaara, Riitta Parkkola, Kirsi A Virtanen
Background and Aim: The metabolic activity of human brown adipose tissue (BAT) has been previously examined using positron emission tomography (PET). The aim of this study was to use proton magnetic resonance spectroscopy (1H MRS) to investigate whether the temperature and the fat fraction (FF) of BAT and white adipose tissue (WAT) are associated with BAT metabolic activity determined by deoxy-2-18F-fluoro-d-glucose (18F-FDG)-PET. Materials and Methods: Ten healthy subjects (four women, six men; 25 to 45 years of age) were studied using PET-magnetic resonance imaging during acute cold exposure and at ambient room temperature...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28284390/creatine-defects-and-central-nervous-system
#18
Carmen Fons, Jaume Campistol
Creatine deficiency syndromes are a group of disorders of creatine (Cr) synthesis and transport characterized by intellectual disability, language delay, epilepsy, autism spectrum disorder, and movement disorders secondary to decrease of Cr concentration in the brain. Synthesis defects are treatable, therefore an early diagnosis and treatment is essential. The aim of this article is to review the Cr metabolism and function in the central nervous system. We describe the optimal diagnostic protocol in Cr deficiency syndromes based on biochemical methods, neuroradiological (1H-MRS), and molecular analysis...
November 2016: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/28236618/common-1h-mrs-characteristics-in-patients-with-alzheimer-s-disease-and-vascular-dementia-diagnosed-with-kidney-essence-deficiency-syndrome-a-preliminary-study
#19
Zhongwei Guo, Xiaozheng Liu, Yulin Cao, Hongtao Hou, Xingli Chen, Yongcan Chen, Feihua Huang, Wei Chen
Context • Traditional Chinese medicine (TCM) indicates that both Alzheimer's disease (AD) and vascular dementia (VD) should be categorized as dementia and that they have a common etiology and pathogenesis under TCM classification of syndromes, such as with kidney essence deficiency syndrome (KEDS). The pathological location is mainly in the brain. However, it remains unclear whether AD and VD patients with KEDS exhibit a metabolic commonality in the same region of the brain. Objective • The study intended to investigate the metabolic characteristics of the brain using proton magnetic resonance spectroscopy (1H-MRS) in patients with AD and VD who had been diagnosed with KEDS...
May 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28195849/detection-and-alterations-of-acetylcarnitine-in-human-skeletal-muscles-by-1h-mrs-at-7-t
#20
Radka Klepochová, Ladislav Valkovič, Martin Gajdošík, Thomas Hochwartner, Harald Tschan, Michael Krebs, Siegfried Trattnig, Martin Krššák
OBJECTIVES: The aims of this study were to detect the acetylcarnitine resonance line at 2.13 ppm in the human vastus lateralis and soleus muscles, assess T1 and T2 relaxation times, and investigate the diurnal and exercise-related changes in absolute concentration noninvasively, using proton magnetic resonance spectroscopy at 7 T. MATERIALS AND METHODS: All measurements were performed on a 7 T whole-body Magnetom MR system with a 28-channel knee coil. Five healthy, moderately trained volunteers participated in the assessment of the detectability, repeatability, and relaxation times of acetylcarnitine...
July 2017: Investigative Radiology
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