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structural MRI, DTI, and 1H-MRS)

Lorena I Petrella, João M Castelhano, Mario Ribeiro, José V Sereno, Sónia I Gonçalves, Mário N Laço, Michael R Hayden, A Cristina Rego, Miguel Castelo-Branco
Huntington's disease (HD) is a neurodegenerative disorder causing cognitive and motor impairments, evolving to death within 15-20 years after symptom onset. We previously established a mouse model with the entire human HD gene containing 128 CAG repeats (YAC128) which accurately recapitulates the natural history of the human disease. Defined time points in this natural history enable the understanding of longitudinal trajectories from the neurochemical and structural points of view using non-invasive high-resolution multi-modal imaging...
June 15, 2018: Human Molecular Genetics
Lauren E Libero, Thomas P DeRamus, Adrienne C Lahti, Gopikrishna Deshpande, Rajesh K Kana
Neuroimaging techniques, such as fMRI, structural MRI, diffusion tensor imaging (DTI), and proton magnetic resonance spectroscopy (1H-MRS) have uncovered evidence for widespread functional and anatomical brain abnormalities in autism spectrum disorder (ASD) suggesting it to be a system-wide neural systems disorder. Nevertheless, most previous studies have focused on examining one index of neuropathology through a single neuroimaging modality, and seldom using multiple modalities to examine the same cohort of individuals...
May 2015: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Myrle M Stouten-Kemperman, Michiel B de Ruiter, Vincent Koppelmans, Willem Boogerd, Liesbeth Reneman, Sanne B Schagen
Adjuvant chemotherapy (CT) for breast cancer (BC) is associated with very late side-effects on brain function and structure. However, little is known about neurotoxicity of specific treatment regimens. To compare neurotoxicity profiles after different treatment strategies, we used neurocognitive testing and multimodality MRI in BC survivors randomized to high-dose (HI), conventional-dose (CON-) CT or radiotherapy (RT) only and a healthy control (HC) group. BC survivors who received CON-CT (n = 20) and HC (n = 20) were assessed using a neurocognitive test battery and multimodality MRI including 3D-T1, Diffusion Tensor Imaging (DTI) and 1H-MR spectroscopy (1H-MRS) to measure various aspects of cerebral white (WM) and gray matter (GM)...
June 2015: Brain Imaging and Behavior
Rex E Jung, Brittany S Mead, Jessica Carrasco, Ranee A Flores
Creativity is a vast construct, seemingly intractable to scientific inquiry-perhaps due to the vague concepts applied to the field of research. One attempt to limit the purview of creative cognition formulates the construct in terms of evolutionary constraints, namely that of blind variation and selective retention (BVSR). Behaviorally, one can limit the "blind variation" component to idea generation tests as manifested by measures of divergent thinking. The "selective retention" component can be represented by measures of convergent thinking, as represented by measures of remote associates...
2013: Frontiers in Human Neuroscience
M G Bruzzone, L D'Incerti, L L Farina, V Cuccarini, G Finocchiaro
Imaging plays a crucial role in the management of patients with brain tumors. The technical improvement of computed tomography (CT) and magnetic resonance (MRI) with the development of, new imaging techniques strongly improved the detection and characterization of brain tumors. For the optimal therapeutic management of the oncologic patient not only the recognition of the lesion is needed, but also the exclusion of other diseases that can mimic brain tumors. The preoperative assessment of malignancy and of relationships of the tumor with surrounding eloquent structures are also necessary to allow the correct choice of therapy and to warn surgeons of possible risks of the surgical approach...
April 2012: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Jitender Saini, Somenath Chatterjee, Bejoy Thomas, Chandrasekharan Kesavadas
BACKGROUND: Tumefactive demyelination (TD) is a relatively uncommon entity which mimics other focal intracranial lesions. Conventional radiological findings in tumefactive demyelination have been well described. However, DTI and MRS findings in TD have not been studied in detail. PURPOSE: To evaluate the usefulness of conventional magnetic resonance imaging (MRI), multivoxel 1H spectroscopy (MRS) and diffusion tensor imaging (DTI) in diagnosis and follow-up of TD of the brain...
December 1, 2011: Acta Radiologica
Cheuk Y Tang, Joseph Friedman, Dikoma Shungu, Linda Chang, Thomas Ernst, Daniel Stewart, Arash Hajianpour, David Carpenter, Johnny Ng, Xiangling Mao, Patrick R Hof, Monte S Buchsbaum, Kenneth Davis, Jack M Gorman
BACKGROUND: Evidence suggests that white matter integrity may play an underlying pathophysiological role in schizophrenia. N-acetylaspartate (NAA), as measured by Magnetic Resonance Spectroscopy (MRS), is a neuronal marker and is decreased in white matter lesions and regions of axonal loss. It has also been found to be reduced in the prefrontal and temporal regions in patients with schizophrenia. Diffusion Tensor Imaging (DTI) allows one to measure the orientations of axonal tracts as well as the coherence of axonal bundles...
June 19, 2007: BMC Psychiatry
V Leuzzi, M Tosetti, D Montanaro, C Carducci, C Artiola, C Carducci, I Antonozzi, M Burroni, F Carnevale, F Chiarotti, T Popolizio, G M Giannatempo, V D'Alesio, T Scarabino
OBJECTIVE: To gain insights into the nature and pathogenesis of white matter (WM) abnormalities in PKU. METHODS: Thirty-two patients with phenylalanine hydroxylase deficiency (21 with early and 11 with late diagnosis and treatment) and 30 healthy controls underwent an integrated clinical, neuroimaging (3.0 T MRI, diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI)) and neurochemical (1H MRS) investigation. RESULTS: All patients had white matter abnormalities on T2-weighted (T2W) and fluid-attenuated inversion recovery (FLAIR) scans; parietal white was consistently affected, followed by occipital, frontal and temporal white matter...
April 2007: Journal of Inherited Metabolic Disease
Paul E Sijens, Roy Irwan, Jan Hendrik Potze, Jop P Mostert, Jacques De Keyser, Matthijs Oudkerk
Primary progressive multiple sclerosis (ppMS; n=4) patients and controls (n=4) were examined by 1H magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) in order to map choline (Cho), creatine and N-acetylaspartate (NAA), the fractional anisotropy (FA) and the apparent diffusion constant (ADC). After chemical shift imaging (point-resolved spectroscopy, repetition time/echo time 1,500 ms/135 ms) of a supraventricular volume of interest of 8x8x2 cm3 (64 voxels) MRS peak areas were matched to the results of DTI for the corresponding volume elements...
August 2005: European Radiology
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