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K Delman

Nadia L Oussayef, Satish K Pillai, Margaret A Honein, C Ben Beard, Beth Bell, Coleen A Boyle, Lars M Eisen, Katrin Kohl, Matthew J Kuehnert, Eva Lathrop, Stacey W Martin, Rebecca Martin, Janet C McAllister, Elizabeth Pantino McClune, Paul Mead, Dana Meaney-Delman, Brett Petersen, Lyle R Petersen, Kara N D Polen, Ann M Powers, Stephen C Redd, James J Sejvar, Tyler Sharp, Julie Villanueva, Denise J Jamieson
The introduction of Zika virus into the Region of the Americas (Americas) and the subsequent increase in cases of congenital microcephaly resulted in activation of CDC's Emergency Operations Center on January 22, 2016, to ensure a coordinated response and timely dissemination of information, and led the World Health Organization to declare a Public Health Emergency of International Concern on February 1, 2016. During the past year, public health agencies and researchers worldwide have collaborated to protect pregnant women, inform clinicians and the public, and advance knowledge about Zika virus (Figure 1)...
January 6, 2017: MMWR. Morbidity and Mortality Weekly Report
Margaret A Honein, April L Dawson, Emily E Petersen, Abbey M Jones, Ellen H Lee, Mahsa M Yazdy, Nina Ahmad, Jennifer Macdonald, Nicole Evert, Andrea Bingham, Sascha R Ellington, Carrie K Shapiro-Mendoza, Titilope Oduyebo, Anne D Fine, Catherine M Brown, Jamie N Sommer, Jyoti Gupta, Philip Cavicchia, Sally Slavinski, Jennifer L White, S Michele Owen, Lyle R Petersen, Coleen Boyle, Dana Meaney-Delman, Denise J Jamieson
Importance: Understanding the risk of birth defects associated with Zika virus infection during pregnancy may help guide communication, prevention, and planning efforts. In the absence of Zika virus, microcephaly occurs in approximately 7 per 10 000 live births. Objective: To estimate the preliminary proportion of fetuses or infants with birth defects after maternal Zika virus infection by trimester of infection and maternal symptoms. Design, Setting, and Participants: Completed pregnancies with maternal, fetal, or infant laboratory evidence of possible recent Zika virus infection and outcomes reported in the continental United States and Hawaii from January 15 to September 22, 2016, in the US Zika Pregnancy Registry, a collaboration between the CDC and state and local health departments...
3, 2017: JAMA: the Journal of the American Medical Association
Emily E Petersen, Dana Meaney-Delman, Robyn Neblett-Fanfair, Fiona Havers, Titilope Oduyebo, Susan L Hills, Ingrid B Rabe, Amy Lambert, Julia Abercrombie, Stacey W Martin, Carolyn V Gould, Nadia Oussayef, Kara N D Polen, Matthew J Kuehnert, Satish K Pillai, Lyle R Petersen, Margaret A Honein, Denise J Jamieson, John T Brooks
CDC has updated its interim guidance for persons with possible Zika virus exposure who are planning to conceive (1) and interim guidance to prevent transmission of Zika virus through sexual contact (2), now combined into a single document. Guidance for care for pregnant women with possible Zika virus exposure was previously published (3). Possible Zika virus exposure is defined as travel to or residence in an area of active Zika virus transmission (, or sex* without a condom(†) with a partner who traveled to or lived in an area of active transmission...
October 7, 2016: MMWR. Morbidity and Mortality Weekly Report
D L Dickstein, M Y Pullman, C Fernandez, J A Short, L Kostakoglu, K Knesaurek, L Soleimani, B D Jordan, W A Gordon, K Dams-O'Connor, B N Delman, E Wong, C Y Tang, S T DeKosky, J R Stone, R C Cantu, M Sano, P R Hof, S Gandy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder most commonly associated with repetitive traumatic brain injury (TBI) and characterized by the presence of neurofibrillary tangles of tau protein, known as a tauopathy. Currently, the diagnosis of CTE can only be definitively established postmortem. However, a new positron emission tomography (PET) ligand, [(18)F]T807/AV1451, may provide the antemortem detection of tau aggregates, and thus various tauopathies, including CTE. Our goal was to examine [(18)F]T807/AV1451 retention in athletes with neuropsychiatric symptoms associated with a history of multiple concussions...
September 27, 2016: Translational Psychiatry
H Danish, K Patel, J Switchenko, T W Gillespie, J Jhaveri, M Chowdhary, M Abugideiri, K A Delman, D H Lawson, M K Khan
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Hasan H Danish, Kirtesh R Patel, Jeffrey M Switchenko, Theresa W Gillespie, Jaymin Jhaveri, Mudit Chowdhary, Mustafa Abugideiri, Keith A Delman, David H Lawson, Mohammad K Khan
Recently, TROG 02.01 results showed that in stage III melanoma patients with nodal metastasis, adjuvant radiation to lymph node basin after nodal dissection improves lymph node field relapse without an overall survival (OS) benefit. However, this trial was neither designed nor powered to detect an OS difference. In the present study, we analyzed patients in the National Cancer Database (NCDB) with stage III melanoma with pathologically involved nodes and compared survival outcomes of adjuvant radiation and no-radiation cohorts...
December 2016: Melanoma Research
Steven C Kim, Jeremy G Fisher, Keith A Delman, Johanna M Hinman, Jahnavi K Srinivasan
OBJECTIVE: Surgical simulation is an important adjunct in surgical education. The majority of operative procedures can be simplified to core components. This study aimed to quantify a cadaver-based simulation course utility in improving exposure to fundamental maneuvers, resident and attending confidence in trainee capability, and if this led to earlier operative independence. DESIGN: A list of fundamental surgical procedures was established by a faculty panel. Residents were assigned to a group led by a chief resident...
November 2016: Journal of Surgical Education
Dana Meaney-Delman, Titilope Oduyebo, Kara N D Polen, Jennifer L White, Andrea M Bingham, Sally A Slavinski, Lea Heberlein-Larson, Kirsten St George, Jennifer L Rakeman, Susan Hills, Christine K Olson, Alys Adamski, Lauren Culver Barlow, Ellen H Lee, Anna M Likos, Jorge L Muñoz, Emily E Petersen, Elizabeth M Dufort, Amy B Dean, Margaret M Cortese, Gilberto A Santiago, Julu Bhatnagar, Ann M Powers, Sherif Zaki, Lyle R Petersen, Denise J Jamieson, Margaret A Honein
OBJECTIVE: Zika virus infection during pregnancy is a cause of microcephaly and other fetal brain abnormalities. Reports indicate that the duration of detectable viral RNA in serum after symptom onset is brief. In a recent case report involving a severely affected fetus, Zika virus RNA was detected in maternal serum 10 weeks after symptom onset, longer than the duration of RNA detection in serum previously reported. This report summarizes the clinical and laboratory characteristics of pregnant women with prolonged detection of Zika virus RNA in serum that were reported to the U...
October 2016: Obstetrics and Gynecology
Titilope Oduyebo, Irogue Igbinosa, Emily E Petersen, Kara N D Polen, Satish K Pillai, Elizabeth C Ailes, Julie M Villanueva, Kim Newsome, Marc Fischer, Priya M Gupta, Ann M Powers, Margaret Lampe, Susan Hills, Kathryn E Arnold, Laura E Rose, Carrie K Shapiro-Mendoza, Charles B Beard, Jorge L Muñoz, Carol Y Rao, Dana Meaney-Delman, Denise J Jamieson, Margaret A Honein
CDC has updated its interim guidance for U.S. health care providers caring for pregnant women with possible Zika virus exposure, to include the emerging data indicating that Zika virus RNA can be detected for prolonged periods in some pregnant women. To increase the proportion of pregnant women with Zika virus infection who receive a definitive diagnosis, CDC recommends expanding real-time reverse transcription-polymerase chain reaction (rRT-PCR) testing. Possible exposures to Zika virus include travel to or residence in an area with active Zika virus transmission, or sex* with a partner who has traveled to or resides in an area with active Zika virus transmission without using condoms or other barrier methods to prevent infection...
July 25, 2016: MMWR. Morbidity and Mortality Weekly Report
Regina M Simeone, Carrie K Shapiro-Mendoza, Dana Meaney-Delman, Emily E Petersen, Romeo R Galang, Titilope Oduyebo, Brenda Rivera-Garcia, Miguel Valencia-Prado, Kimberly B Newsome, Janice Pérez-Padilla, Tonya R Williams, Matthew Biggerstaff, Denise J Jamieson, Margaret A Honein
Zika virus is a cause of microcephaly and brain abnormalities (1), and it is the first known mosquito-borne infection to cause congenital anomalies in humans. The establishment of a comprehensive surveillance system to monitor pregnant women with Zika virus infection will provide data to further elucidate the full range of potential outcomes for fetuses and infants of mothers with asymptomatic and symptomatic Zika virus infection during pregnancy. In February 2016, Zika virus disease and congenital Zika virus infections became nationally notifiable conditions in the United States (2)...
May 27, 2016: MMWR. Morbidity and Mortality Weekly Report
Emily E Petersen, Kara N D Polen, Dana Meaney-Delman, Sascha R Ellington, Titilope Oduyebo, Amanda Cohn, Alexandra M Oster, Kate Russell, Jennifer F Kawwass, Mateusz P Karwowski, Ann M Powers, Jeanne Bertolli, John T Brooks, Dmitry Kissin, Julie Villanueva, Jorge Muñoz-Jordan, Matthew Kuehnert, Christine K Olson, Margaret A Honein, Maria Rivera, Denise J Jamieson, Sonja A Rasmussen
CDC has updated its interim guidance for U.S. health care providers caring for women of reproductive age with possible Zika virus exposure to include recommendations on counseling women and men with possible Zika virus exposure who are interested in conceiving. This guidance is based on limited available data on persistence of Zika virus RNA in blood and semen. Women who have Zika virus disease should wait at least 8 weeks after symptom onset to attempt conception, and men with Zika virus disease should wait at least 6 months after symptom onset to attempt conception...
2016: MMWR. Morbidity and Mortality Weekly Report
Stefan Katharios-Lanwermeyer, Jon-Erik Holty, Marissa Person, James Sejvar, Dana Haberling, Heather Tubbs, Dana Meaney-Delman, Satish K Pillai, Nathaniel Hupert, William A Bower, Katherine Hendricks
BACKGROUND: Bacillus anthracis, the causative agent of anthrax, is a potential bioterrorism agent. Anthrax meningitis is a common manifestation of B. anthracis infection, has high mortality, and requires more aggressive treatment than anthrax without meningitis. Its rapid identification and treatment are essential for successful management of an anthrax mass casualty incident. METHODS: Three hundred six published reports from 1880 through 2013 met predefined inclusion criteria...
June 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Christine K Olson, Martha Iwamoto, Kiran M Perkins, Kara N D Polen, Jeffrey Hageman, Dana Meaney-Delman, Irogue I Igbinosa, Sumaiya Khan, Margaret A Honein, Michael Bell, Sonja A Rasmussen, Denise J Jamieson
Zika virus transmission was detected in the Region of the Americas (Americas) in Brazil in May 2015, and as of March 21, 2016, local mosquito-borne transmission of Zika virus had been reported in 32 countries and territories in the Americas, including Puerto Rico and the U.S. Virgin Islands.* Most persons infected with Zika virus have a mild illness or are asymptomatic. However, increasing evidence supports a link between Zika virus infection during pregnancy and adverse pregnancy and birth outcomes (1), and a possible association between recent Zika virus infection and Guillain-Barré syndrome has been reported (2)...
2016: MMWR. Morbidity and Mortality Weekly Report
Dana Meaney-Delman, Susan L Hills, Charnetta Williams, Romeo R Galang, Preetha Iyengar, Andrew K Hennenfent, Ingrid B Rabe, Amanda Panella, Titilope Oduyebo, Margaret A Honein, Sherif Zaki, Nicole Lindsey, Jennifer A Lehman, Natalie Kwit, Jeanne Bertolli, Sascha Ellington, Irogue Igbinosa, Anna A Minta, Emily E Petersen, Paul Mead, Sonja A Rasmussen, Denise J Jamieson
After reports of microcephaly and other adverse pregnancy outcomes in infants of mothers infected with Zika virus during pregnancy, CDC issued a travel alert on January 15, 2016, advising pregnant women to consider postponing travel to areas with active transmission of Zika virus. On January 19, CDC released interim guidelines for U.S. health care providers caring for pregnant women with travel to an affected area, and an update was released on February 5. As of February 17, CDC had received reports of nine pregnant travelers with laboratory-confirmed Zika virus disease; 10 additional reports of Zika virus disease among pregnant women are currently under investigation...
March 4, 2016: MMWR. Morbidity and Mortality Weekly Report
Kevin E Fisher, Linsheng Zhang, Jason Wang, Geoffrey H Smith, Scott Newman, Thomas M Schneider, Rathi N Pillai, Ragini R Kudchadkar, Taofeek K Owonikoko, Suresh S Ramalingam, David H Lawson, Keith A Delman, Bassel F El-Rayes, Malania M Wilson, H Clifford Sullivan, Annie S Morrison, Serdar Balci, N Volkan Adsay, Anthony A Gal, Gabriel L Sica, Debra F Saxe, Karen P Mann, Charles E Hill, Fadlo R Khuri, Michael R Rossi
We tested and clinically validated a targeted next-generation sequencing (NGS) mutation panel using 80 formalin-fixed, paraffin-embedded (FFPE) tumor samples. Forty non-small cell lung carcinoma (NSCLC), 30 melanoma, and 30 gastrointestinal (12 colonic, 10 gastric, and 8 pancreatic adenocarcinoma) FFPE samples were selected from laboratory archives. After appropriate specimen and nucleic acid quality control, 80 NGS libraries were prepared using the Illumina TruSight tumor (TST) kit and sequenced on the Illumina MiSeq...
March 2016: Journal of Molecular Diagnostics: JMD
Alisa K Lincoln, Lori Wallace, Mary Sharon Kaminski, Kirstin Lindeman, Louise Aulier, Jonathan Delman
Psychiatric emergency services (PES) remain a critical and under-examined component of the community mental health system. We describe how a unique community-academic partnership came together to examine repeat use of PES through the design and conduct of a qualitative study using a CBPR approach. The goals of the project were to: (1) develop a model of research which promoted the inclusion of people who use mental health services in the research process; and (2) design and conduct a study to examine the repeat use of PES through the inclusion of the perspectives and experiences of people who use these services...
January 22, 2016: Community Mental Health Journal
Eileen Huang, Satish K Pillai, William A Bower, Katherine A Hendricks, Julie T Guarnizo, Jamechia D Hoyle, Susan E Gorman, Anne E Boyer, Conrad P Quinn, Dana Meaney-Delman
Concern about use of anthrax as a bioweapon prompted development of novel anthrax antitoxins for treatment. Clinical guidelines for the treatment of anthrax recommend antitoxin therapy in combination with intravenous antimicrobials; however, a large-scale or mass anthrax incident may exceed antitoxin availability and create a need for judicious antitoxin use. We conducted a systematic review of antitoxin treatment of inhalation anthrax in humans and experimental animals to inform antitoxin recommendations during a large-scale or mass anthrax incident...
November 2015: Health Security
Satish K Pillai, Eileen Huang, Julie T Guarnizo, Jamechia D Hoyle, Stefan Katharios-Lanwermeyer, Theresa K Turski, William A Bower, Katherine A Hendricks, Dana Meaney-Delman
Systemic anthrax is associated with high mortality. Current national guidelines, developed for the individualized treatment of systemic anthrax, outline the use of combination intravenous antimicrobials for a minimum of 2 weeks, bactericidal and protein synthesis inhibitor antimicrobials for all cases of systemic anthrax, and at least 3 antimicrobials with good blood-brain barrier penetration for anthrax meningitis. However, in an anthrax mass casualty incident, large numbers of anthrax cases may create challenges in meeting antimicrobial needs...
November 2015: Health Security
Devora M Delman, Carol J Fabian, Bruce F Kimler, Henry Yeh, Brian K Petroff
Breast cancer prevention efforts are focused increasingly on potentially beneficial dietary modifications due to their ease of implementation and wide acceptance. Secoisolariciresinol diglucoside (SDG) is a lignan found in high concentration in flaxseed that may have selective estrogen receptor modulator-like effects resulting in antiestrogenic activity in a high estrogen environment. In parallel with a human phase II prevention trial, female ACI rats (n = 8-10/group) received 0, 10, or 100 ppm SDG in the feed...
2015: Nutrition and Cancer
Martina L Badell, Dana Meaney-Delman, Methodius G Tuuli, Sonja A Rasmussen, Brett W Petersen, Jeanne S Sheffield, Richard H Beigi, Inger K Damon, Denise J Jamieson
OBJECTIVE: To estimate the maternal and fetal risks of smallpox vaccination during pregnancy. DATA SOURCES: MEDLINE, Web of Science, EMBASE, Global Health,, and CINHAL from inception to September 2014. METHODS OF STUDY SELECTION: We included published articles containing primary data regarding smallpox vaccination during pregnancy that reported maternal or fetal outcomes (spontaneous abortion, congenital defect, stillbirth, preterm birth, or fetal vaccinia)...
June 2015: Obstetrics and Gynecology
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