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Saja Ahmad Karaja, Mai Abdulsalam Halloum, Sanaa Yasser Mansour, Alae Aldin Almasri
INTRODUCTION AND IMPORTANCE: Melanoma represents only 1% of all skin cancers. Acral lentigious melanoma (ALM) which usually arises from feet, is the rarest main subtype of melanoma. Subungual melanoma (SUM) is a rare variant of ALM. Amelanotic melanoma (AM) is found only in 4-27.5% of melanomas, and the mean age for patients affected by AM exceeds 50 years. Late diagnosing leads to unfavourable prognosis. CASE PRESENTATION: The authors present a case of subungual amelanotic melanoma that affected the nail unit of the right thumb which is a rare case, especially when the patient is only 39 years old...
April 2024: Annals of Medicine and Surgery
#22
JOURNAL ARTICLE
Insiyah Campwala, Paolo D A Vignali, Brittani Kn Seynnaeve, Alexander J Davit, Kurt Weiss, Marcus M Malek
BACKGROUND: Indocyanine green (ICG) is a fluorescent dye with increasing use for adult sentinel lymph node biopsy (SLNB). The utility of ICG in pediatric oncology remains understudied. We aim to describe our experience using ICG for SLNB in pediatrics versus standard blue dye. METHODS: A retrospective review of pediatric patients with melanoma or sarcoma who underwent SLNB with technetium plus ICG or blue dye from 2014 to 2023 at a large academic children's hospital was conducted...
March 14, 2024: Journal of Pediatric Surgery
#23
JOURNAL ARTICLE
Xue Bai, Ahmed Shaheen, Charlotte Grieco, Paolo D d'Arienzo, Florentia Mina, Juliane A Czapla, Aleigha R Lawless, Eleonora Bongiovanni, Umberto Santaniello, Helena Zappi, Dominika Dulak, Andrew Williamson, Rebecca Lee, Avinash Gupta, Caili Li, Lu Si, Martina Ubaldi, Naoya Yamazaki, Dai Ogata, Rebecca Johnson, Benjamin C Park, Seungyeon Jung, Gabriele Madonna, Juliane Hochherz, Yoshiyasu Umeda, Yasuhiro Nakamura, Christoffer Gebhardt, Lucia Festino, Mariaelena Capone, Paolo Antonio Ascierto, Douglas B Johnson, Serigne N Lo, Georgina V Long, Alexander M Menzies, Kenjiro Namikawa, Mario Mandala, Jun Guo, Paul Lorigan, Yana G Najjar, Andrew Haydon, Pietro Quaglino, Genevieve M Boland, Ryan J Sullivan, Andrew J S Furness, Ruth Plummer, Keith T Flaherty
No abstract text is available yet for this article.
May 2024: EClinicalMedicine
#24
JOURNAL ARTICLE
Markéta Pícková, Zuzana Kahounová, Tomasz Radaszkiewicz, Jiřina Procházková, Radek Fedr, Michaela Nosková, Katarzyna Anna Radaszkiewicz, Petra Ovesná, Vítězslav Bryja, Karel Souček
Metastatic melanoma, a highly lethal form of skin cancer, presents significant clinical challenges due to limited therapeutic options and high metastatic capacity. Recent studies have demonstrated that cancer dissemination can occur earlier, before the diagnosis of the primary tumor. The progress in understanding the kinetics of cancer dissemination is limited by the lack of animal models that accurately mimic disease progression. We have established a xenograft model of human melanoma that spontaneously metastasizes to lymph nodes and lungs...
April 3, 2024: Scientific Reports
#25
JOURNAL ARTICLE
Antoine Braud, Pierre Auloge, Nicolas Meyer, Caroline Bouvrais, Mousselim Gharbi, Hervé Lang, Afshin Gangi, Dan Lipsker
PURPOSE: Complete lymph node dissection is the recommended treatment for clinically detectable lymph nodes in stage III melanoma. This surgery is associated with substantial morbidity. We hypothesize that combining percutaneous imaging-guided cryoablation of locoregional lymph nodes metastases with neoadjuvant in situ and systemic immunotherapy could allow disease control and evaluate the feasibility of this combination in this proof-of-concept study. METHODS: We enrolled 15 patients with stage IIIB/IIIC melanoma...
April 3, 2024: Cardiovascular and Interventional Radiology
#26
JOURNAL ARTICLE
Hiroko Okabayashi, Seiya Nakashima, Kosuke Fujino, Miyu Imai, Shohei Hamada, Aiko Masunaga, Hidenori Ichiyasu, Makoto Suzuki, Takuro Sakagami
Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM)-associated interstitial lung disease (ILD) can sometimes be complicated by pneumomediastinum, although tension pneumomediastinum is extremely rare. We herein report a case of anti-MDA5 antibody-positive DM-ILD that worsened subcutaneous and mediastinal emphysema during treatment. Hypotension and worsening respiratory failure were observed on day 20 of treatment. Mediastinal drainage under video-assisted thoracoscopic surgery promptly improved the patient's circulatory and respiratory status...
April 2, 2024: Internal Medicine
#27
JOURNAL ARTICLE
Ram Krishan, Sachita Pandey, Puja Sakhuja, Surbhi Goyal, Krishna Bhardwaj, B G Vageesh, Anil K Agarwal
Melanoma is a relatively rare malignancy with a highly aggressive biological behavior. Metastases to other sites, like lymph nodes and liver are common, but primary hepatic melanoma is a rarity with poor survival ranging from months to few years. Diagnosis of primary hepatic melanoma via clinical features and imaging technology is difficult because of its ambiguous features. Here, we present a 26-year-old North Indian woman admitted in the department of gastrointestinal surgery at our tertiary care hospital with the complaint of pain in the abdomen for a month associated with the loss of appetite and subsequent weight loss...
April 3, 2024: International Journal of Surgical Pathology
#28
Syeda Sara Tajammul, Salim Chaib Rassou, Javeria Munir, Zubair Ahmed, Asma Naaz Nadaf
Primary intracranial meningeal melanomas are rare. Diagnosing primary meningeal melanomas mostly involves comprehensive assessment through clinical and radiological means. This evaluation should encompass a detailed dermal and ophthalmic examination. Any suspicious lesion must be biopsied and examined microscopically. This is crucial not only to differentiate primary intracranial melanoma from other brain tumors but also to rule out metastases from potential sources of primary cutaneous or non-cutaneous melanomas...
March 2024: Curēus
#29
JOURNAL ARTICLE
R Salih, F Ismail, G E Orchard
Introduction: Lentigo maligna (LM) and lentigo maligna melanoma (LMM) predominantly affect the head and neck areas in elderly patients, presenting as challenging ill-defined pigmented lesions with indistinct borders. Surgical margin determination for complete removal remains intricate due to these characteristics. Morphological examination of surgical margins is the key form of determining successful treatment in LM/LMM and underpin the greater margin control provided through the Slow Mohs micrographic surgery (SMMS) approach...
2024: British Journal of Biomedical Science
#30
JOURNAL ARTICLE
Yuanyuan Xia, Albert Taiching Liao, Jihjong Lee
BACKGROUND: Effective treatment for canine oral malignant melanoma ( e.g. , curative-intent surgery) may not be feasible or radiation therapy may be unavailable. However, chemotherapy is usually an option, and more information is needed regarding its use without adequate local treatments. OBJECTIVE: Our objective was to investigate the efficacy of chemotherapy in canine oral malignant melanoma without adequate local control, using carboplatin with dose reduction in small-breed dogs and metronomic chemotherapy...
April 2024: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
#31
JOURNAL ARTICLE
Morgan E Roberts, Katie Vines, Frances G Sullivan, Thuy Phung, Joe S Liles, John H Howard
No abstract text is available yet for this article.
April 2, 2024: American Surgeon
#32
JOURNAL ARTICLE
Chen Shen, Jennifer K Shah, Priscila Cevallos, Rahim Nazerali, Joseph M Rosen
INTRODUCTION: Treatment for melanoma after a positive sentinel lymph node biopsy includes nodal observation or lymphadenectomy. Important considerations for management, however, involve balancing the risk of recurrence and the risk of lymphedema after lymphadenectomy. METHODS: From the Merative MarketScan Research Databases, adult patients were queried from 2007 to 2021. International Classification of Disease, Ninth (ICD-9) and Tenth (ICD-10) Editions, diagnosis codes and Current Procedural Terminology codes were used to identify patients with melanoma diagnoses who underwent an index melanoma excision with a positive sentinel lymph node biopsy (SLNB)...
April 1, 2024: Annals of Plastic Surgery
#33
JOURNAL ARTICLE
Omar Ani, Wen Xu, Benjamin Chang, Ines C Lin
HYPOTHESIS: The natural history of pediatric melanonychia and the necessity of biopsy for ruling out melanoma are debated in the literature. We hypothesize that there is a low rate of malignant nail pathology among pediatric patients undergoing nail bed biopsy for melanonychia. METHODS: We performed a retrospective chart review of 54 pediatric patients (age <18 years) at a single institution who presented with melanonychia and underwent nail bed biopsy from 2007 to 2022...
April 1, 2024: Annals of Plastic Surgery
#34
JOURNAL ARTICLE
Rachel C Hill, Benedict Ho, Shari R Lipner
No abstract text is available yet for this article.
March 29, 2024: Journal of the American Academy of Dermatology
#35
JOURNAL ARTICLE
Alicia C Greene, Olivia Ziegler, McKell Quattrone, Michael J Stack, Benjamin Becker, Colette R Pameijer, Chan Shen
BACKGROUND: Early detection and standardized treatment are crucial for enhancing outcomes for patients with cutaneous melanoma, the commonly diagnosed skin cancer. However, access to quality health care services remains a critical barrier for many patients, particularly the uninsured. Whereas Medicaid expansion (ME) has had a positive impact on some cancers, its specific influence on cutaneous melanoma remains understudied. METHODS: The National Cancer Database identified 87,512 patients 40-64 years of age with a diagnosis of non-metastatic cutaneous melanoma between 2004 and 2017...
March 29, 2024: Annals of Surgical Oncology
#36
JOURNAL ARTICLE
Mary E McMinn, Kelly A Brister, W Shannon Orr, Natale T Sheehan, Wade O Christopher
Melanoma is an aggressive malignancy accounting for approximately 1% of all skin cancers. The standard of care for distant melanoma of the skin is immunotherapy with PD-1 inhibitors (nivolumab) or CTLA-4 inhibitors. In March 2022, the FDA approved the combination of nivolumab with relatlimab, a lymphocyte-activation gene 3 antibody. There are few reports on the efficacy of treating widespread multivisceral metastatic melanoma with nivolumab plus relatlimab with a complete clinical response. We describe the diagnosis and management of a patient with metastatic nodular melanoma treated with palliative resection of the primary tumor followed by immunotherapy with nivolumab and relatlimab...
March 29, 2024: American Surgeon
#37
Akira Yoneda, Ryosuke Ogata, Shintaro Ryu, Kyohei Yoshino, Saeko Fukui, Takahiro Ikeda, Amane Kitasato, Nozomu Sugiyama, Hiroaki Takeshita, Shigeki Minami, Masahiro Ito, Tamotsu Kuroki
INTRODUCTION: Primary malignant melanoma of the esophagus is a very rare disease with a poor prognosis. We herein report a patient with primary malignant melanoma of the esophagus who underwent surgical resection. CASE PRESENTATION: A 73-year-old female underwent an upper gastrointestinal endoscopy during follow-up for colonic diverticulitis. An endoscopic examination and constructed radiography revealed a slightly elevated black pigmented lesion in the upper esophagus and a black pigmented area in the esophagogastric junction...
2024: Case Reports in Gastroenterology
#38
Claire V Ong, Wolfram Samlowski
Mucosal melanoma represents an uncommon melanoma subtype. Wide excision has long represented the standard therapeutic approach. Unfortunately, there is a high relapse rate and mortality. Neoadjuvant therapy with ipilimumab plus nivolumab has shown significant activity in cutaneous melanoma. We present two cases of mucosal melanoma, each with potential regional dissemination, who were treated with neoadjuvant immunotherapy with minimal toxicity. Both patients were closely monitored and achieved radiologic and pathologic complete responses...
2024: Frontiers in Oncology
#39
JOURNAL ARTICLE
F Grace Sullivan, Keith B Adler, Madeleine D Boudreaux, Lexie M Hensley, Morgan E Roberts, J Spencer Liles, J Harrison Howard
Melanoma surveillance guidelines vary. Melanoma recurrence patterns and detection methods were examined. Resected melanoma patients were reviewed. Recurrence detection included patient complaint (PC), physical exam (PE), cross-sectional imaging (CSI), and ultrasound (US). 276 patients were included: 131 stage I, 83 stage II, and 62 stage III. Recurrence rates were 8%, 24%, and 27%, respectively. For stage I patients, 46% of recurrences were local, 18% regional, and 36% distant. Patient complaint identified 55% of recurrences, PE 36%, and CSI 9%...
March 28, 2024: American Surgeon
#40
JOURNAL ARTICLE
Miguel T Campos, Filipa A L S Silva, José Ramiro Fernandes, Susana G Santos, Fernão D Magalhães, Maria J Oliveira, Artur M Pinto
Non-melanoma skin cancer (NMSC) is one of the most common types of cancer worldwide. Despite the low mortality rate, rising incidence and recurrence rates are a burden on healthcare systems. Standard treatments such as chemotherapy, radiotherapy, and surgery are either invasive or toxic to healthy tissues; therefore, new, alternative, selective treatments are needed. In this work, a combined photothermal and chemotherapeutic approach is proposed. MoS2 was used as photothermal agent. It was prepared by a liquid-phase exfoliation and intercalation method using polyvinylpyrrolidone (PVP), followed by recirculation through a custom-built high-power ultrasonication probe...
March 4, 2024: Pharmaceutics
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