keyword
https://read.qxmd.com/read/38401462/the-emerging-role-of-%C3%AE-7nachrs-caspase-3-nrf-2-signaling-pathway-in-citicoline-improved-autistic-behavior-induced-by-thimerosal-in-mice
#1
JOURNAL ARTICLE
Nourhan A Khattab, Aya H El-Kadem, Samar S Elblehi, Nageh Ahmed El-Mahdy, Nagla A El-Shitany
AIMS: Autism spectrum disorder (ASD) is a global concern,affecting around 75 million individuals.Various factors contribute to ASD,including mercury-containing preservatives like thimerosal (Thim) found in some vaccines.This study explored whether citicoline could be a therapeutic option for Thim-induced neuronal damage in a mouse model of ASD.Additionally,the study investigated the effects of citicoline on the α7nAChRs/Akt/Nrf2/caspase-3 pathway,which may be involved in the development of ASD...
February 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38332973/creating-a-low-stimulus-clinic-to-improve-immunization-success-rates-for-children-with-alternate-environment-needs-a-quality-improvement-initiative
#2
JOURNAL ARTICLE
Megan McDonald, Shauna Gallaugher, Elise Kammerer, Samina Ali
Patients with specific sensory needs may face barriers to receiving their immunizations. Therefore, a Low-Stimulus Clinic was created in Alberta. Modifications to regular clinic space included lower visual and auditory input, access to longer appointment times and private clinic spaces, development of pre-appointment comfort plans, and offering of in-vehicle immunization. Between April 2021 and May 2022, 90% (641/712) of booked patients were successfully immunized. The top reasons for accessing the clinic included autism spectrum disorder (229/712, 32%), and needle fear/phobia (195/712, 27%)...
February 2024: Paediatrics & Child Health
https://read.qxmd.com/read/38326911/exploring-knowledge-of-autism-its-causes-and-treatment-among-immigrant-and-nonimmigrant-parents-in-somalia-somaliland
#3
JOURNAL ARTICLE
Hodan A Duale, Abdi Gele
BACKGROUND: The prevalence of autism spectrum disorders (ASDs) has increased over the recent years; however, little is known about the experience of parents of children with autism in Africa such as Somalia. The aim of this study is to understand the knowledge on autism of Somali parents of children with autism and their perceptions of causes and treatment of ASD. METHODS: We conducted a qualitative study involving 22 parents of children with autism who lived in Mogadishu and Hargeisa; the two largest cities in Somalia...
February 7, 2024: Child and Adolescent Psychiatry and Mental Health
https://read.qxmd.com/read/38245390/mixed-methods-examination-of-attitudes-and-behaviors-related-to-covid-19-vaccines-among-parents-of-children-with-autism-and-autistic-adults
#4
JOURNAL ARTICLE
Melissa M Mitchell, Adriana Klott, Jared Scholtes, B Blair Braden, Christopher J Smith, Nicole L Matthews
Increased risks associated with Coronavirus disease 2019 (COVID-19) among individuals with autism spectrum disorder (ASD) combined with previous reports of heightened vaccine hesitancy among parents of children with ASD indicate the need for a better understanding of attitudes and behaviors related to COVID-19 vaccines among the ASD community. This study is the first to our knowledge to use a mixed-methods approach to understand attitudes toward COVID-19 vaccines among parents of children with ASD and autistic adults...
January 19, 2024: Vaccine
https://read.qxmd.com/read/38204225/environmental-risk-factors-in-autism-spectrum-disorder-a-narrative-review
#5
JOURNAL ARTICLE
Konstantin Yenkoyan, Meri Mkhitaryan, Geir Bjørklund
Existing evidence indicates that environmental factors might contribute up to 50% of the variance in autism spectrum disorder (ASD) risk. This structured narrative review offers a comprehensive synthesis of current knowledge on environmental risk factors in ASD, including evaluation of conflicting evidence, exploration of underlying mechanisms, and suggestions for future research directions. Analysis of diverse epidemiological investigations indicates that certain environmental factors, including advanced parental age, preterm birth, delivery complications, and exposure to toxic metals, drugs, air pollutants, and endocrine-disrupting chemicals, are linked to an increased ASD risk through various mechanisms such as oxidative stress, inflammation, hypoxia, and its consequences, changes in neurotransmitters, disruption of signaling pathways and some others...
January 10, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38198049/prenatal-exposure-to-covid-19-mrna-vaccine-bnt162b2-induces-autism-like-behaviors-in-male-neonatal-rats-insights-into-wnt-and-bdnf-signaling-perturbations
#6
JOURNAL ARTICLE
Mumin Alper Erdogan, Orkun Gurbuz, Mehmet Fatih Bozkurt, Oytun Erbas
The COVID-19 pandemic catalyzed the swift development and distribution of mRNA vaccines, including BNT162b2, to address the disease. Concerns have arisen about the potential neurodevelopmental implications of these vaccines, especially in susceptible groups such as pregnant women and their offspring. This study aimed to investigate the gene expression of WNT, brain-derived neurotrophic factor (BDNF) levels, specific cytokines, m-TOR expression, neuropathology, and autism-related neurobehavioral outcomes in a rat model...
April 2024: Neurochemical Research
https://read.qxmd.com/read/37977941/assessing-parental-intention-to-vaccinate-against-covid-19-influenza-and-rsv-in-the-united-states-in-late-2023
#7
JOURNAL ARTICLE
Simon F Haeder
Vaccine hesitancy is a substantial public health threat. We used a national survey to query parents about their intention to vaccinate their children against COVID-19, influenza, and RSV in the fall and winter 2023-2024. We found that about 40% of parents intended to vaccinate their children against COVID-19, 63% against influenza, and 71% against RSV. Intention to vaccinate was consistently correlated with concerns about the disease, trust in health institutions, and previous vaccinations. Women showed lower intentions for COVID-19 and influenza...
November 15, 2023: Vaccine
https://read.qxmd.com/read/37858447/u-s-public-support-and-opposition-to-vaccination-mandates-in-k-12-education-in-light-of-the-covid-19-pandemic
#8
JOURNAL ARTICLE
Simon F Haeder
BACKGROUND: Vaccination mandates have long been an effective tool in increasing vaccination rates and reducing the potential for disease outbreaks. In the wake of COVID-19, opposition to mandates in the K-12 setting has garnered more attention, and policymakers opposed to them have become more active. This study sought to assess whether these efforts are supported by the U.S. public. METHODS: We fielded a large, national survey (N = 16,461) from January to April of 2022 to assess U...
November 22, 2023: Vaccine
https://read.qxmd.com/read/37773493/overall-and-cervical-cancer-survival-in-patients-with-and-without-mental-disorders
#9
JOURNAL ARTICLE
Eva Herweijer, Jiangrong Wang, Kejia Hu, Unnur A Valdimarsdóttir, Hans-Olov Adami, Pär Sparén, Karin Sundström, Fang Fang
IMPORTANCE: Individuals with a mental disorder experience substantial health disparity and are less likely to participate in cervical screening and human papillomavirus vaccination. Additionally, this population may benefit less from tertiary cancer prevention. OBJECTIVE: To compare clinical characteristics and survival patterns between patients with cervical cancer with and without a preexisting diagnosis of a mental disorder at the time of cervical cancer diagnosis...
September 5, 2023: JAMA Network Open
https://read.qxmd.com/read/37766077/a-qualitative-analysis-of-social-ecological-factors-shaping-childhood-immunisation-hesitancy-and-delay-in-the-eastern-province-of-saudi-arabia
#10
JOURNAL ARTICLE
Marwa Alabadi, Victoria Pitt, Zakariya Aldawood
(1) Background: Immunisation is a crucial and effective method for preventing infectious diseases, with its success dependent on high immunisation rates to protect under-immunised individuals and promote herd immunity. This qualitative descriptive study is part of a larger explanatory sequential mixed method design that aims to explore factors influencing parents' decision making to complete childhood immunisation in the Eastern Province of Saudi Arabia, a country experiencing disparities in immunisation coverage across its population...
August 22, 2023: Vaccines
https://read.qxmd.com/read/37759331/correction-to-acceptance-of-covid-19-vaccination-among-parents-of-children-with-autism-and-other-neurodevelopmental-disorders-in-saudi-arabia-a-cross-sectional-study
#11
Ali Jawad Al Saad, Mohammed Ghadeer Alhassan, Maryam Saleh, Fatimah Fathi Alqattan, Fatimah Ali Aleisa, Hawra Wasel Abdulmohsen
No abstract text is available yet for this article.
September 28, 2023: BMC Public Health
https://read.qxmd.com/read/37750434/-the-silent-shot-an-analysis-of-the-origin-sustenance-and-implications-of-the-mmr-vaccine-autism-rumour-in-the-somali-diaspora-in-sweden-and-beyond
#12
JOURNAL ARTICLE
Sibylle Herzig van Wees, Samira Dini
This article traces the origin, sustenance and implications of a persistent rumour that is responsible for low measles mumps and rubella (MMR) vaccination uptake in the Somali diaspora in a number of countries across the globe. The rumour stipulates that the MMR vaccine - the silent shot - causes autism spectrum disorder (ASD). Although the association between MMR and ASD is non-causal, and various public health initiatives have promoted health information campaigns, the rumour continues to circulate in the Somali diaspora in many countries, including Sweden...
January 2023: Global Public Health
https://read.qxmd.com/read/37744481/factors-associated-with-covid-19-vaccine-confidence-among-primary-care-providers-in-kazakhstan-march-april-2021
#13
JOURNAL ARTICLE
Dilyara Nabirova, Roberta Horth, Lena Kassabekova, Alden Henderson, Aizhan Yesmagambetova, Sevak Alaverdyan, J Pekka Nuorti, Manar Smagul
INTRODUCTION: Vaccination is a critical public health intervention, and vaccine hesitancy is a major threat. Globally, confidence in COVID-19 vaccines has been low, and rates of routine immunizations decreased during the COVID-19 pandemic. Because healthcare providers are a trusted source of information on vaccination in Kazakhstan, it was vital to understand their knowledge, attitudes and practices (KAP) related to both routine and COVID-19 vaccines. METHODS: From March to April 2021, we conducted a cross-sectional study among the healthcare providers responsible for vaccination in 54 primary care facilities in three cities in Kazakhstan...
2023: Frontiers in Public Health
https://read.qxmd.com/read/37722656/acute-mastoiditis-in-cochlear-implanted-children-a-single-centre-experience
#14
JOURNAL ARTICLE
Andrea Ciorba, Virginia Fancello, Beatrice Sacchet, Michela Borin, Nicola Malagutti, Chiara Bianchini, Francesco Stomeo, Stefano Pelucchi
BACKGROUND: Acute mastoiditis (AM) is the most common complication of acute otitis media and primarily affects children under the age of two; current data on its prevalence in paediatric patients with cochlear implant (CI) are still scant. Proper management of AM in CI children is crucial in order to avoid the implications (financial and emotional) of an explant. Aim of this paper is to describe the cases of AM occurred among young patients with CI in follow up at our department, also in order to evaluate its prevalence, potential predisposing factors, clinical course and therapeutic strategies...
September 16, 2023: Acta otorrinolaringologica española
https://read.qxmd.com/read/37605699/the-needle-anxiety-program-a-patient-centered-initiative-for-individuals-with-developmental-disabilities
#15
JOURNAL ARTICLE
Julianna Rava, Kashia A Rosenau, Kendal Wilkie, Jessica Bernacki, Eric Curcio, Alice Kuo
Objective To describe the development process of a patient-centered initiative focused on improving primary care health outcomes of patients with intellectual and developmental disabilities (IDD) and needle-related anxiety using evidence-based practices and novel approaches that can be implemented in outpatient settings. The overall outcome of the program is to increase vaccine uptake and accessibility in the IDD population as well as improve needle-related procedures in primary care settings to be more humane and effective...
July 2023: Curēus
https://read.qxmd.com/read/37602094/implementation-of-a-minimal-sedation-protocol-for-patients-with-developmental-disabilities-and-needle-phobia
#16
JOURNAL ARTICLE
Julianna Rava, Kashia A Rosenau, Kendal Wilkie, Eric Curcio, Alice Kuo
Objective Patients with intellectual and developmental disabilities (IDD) experience needle phobia at greater rates than individuals in the general population. Needle phobia deters patients with IDD from receiving routine medical procedures, which impacts their physical health outcomes. The aim of this quality improvement study was to assess the feasibility of a minimal sedation protocol in an outpatient care setting for patients with IDD and needle phobia. Methods The sample included 18 patients characterized as having a diagnosis of IDD only or IDD and needle phobia compared to patients with only a diagnosis of needle phobia...
July 2023: Curēus
https://read.qxmd.com/read/37589194/thiamine-metabolism-dysfunction-syndrome-5-thmd5-mimicking-acute-disseminated-encephalomyelitis
#17
Zachary E Thompson, Natalie K Boyd, Mellad M Khoshnood, Jonathan D Santoro
Thiamine pyrophosphate (TPP), the substrate of Thiamine pyrophosphate kinase (TPK), is an important cofactor in carbohydrate metabolism, specifically as a cofactor of the Pyruvate dehydrogenase complex (PDH) complex. The nervous system is particularly dependent on TPP due to its reliance on glucose metabolism. In this case, a four-year-old girl had a previously unreported pathogenic variant of the gene encoding TPK (TPK1) which presented as Thiamine metabolism dysfunction syndrome 5 (THMD5; OMIM 614458). She had been diagnosed with acute disseminated encephalomyelitis and autism spectrum disorder (ASD), and initially presented with fever and agitation following vaccinations...
December 2023: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/37575828/knowledge-attitude-and-practice-of-vaccination-among-parents-in-jeddah-city-saudi-arabia
#18
JOURNAL ARTICLE
Amany Ali Alghamdi, Hani A Alghamdi
Background Vaccine misconception plays an important role in delaying vaccination for children, which can lead to serious health problems. Assessing the knowledge, attitude, and practice (KAP) and potential associated factors among Saudi parents of preschool and school-age children and adolescents for all types of vaccines would help increase vaccine coverage. Methodology This cross-sectional, questionnaire-based survey was performed among parents in Jeddah, Saudi Arabia. The study enrolled all Saudi parents visiting primary healthcare centers (PHC) in Jeddah with their children aged 3-18 years old...
July 2023: Curēus
https://read.qxmd.com/read/37365523/acceptance-of-covid-19-vaccination-among-parents-of-children-with-autism-and-other-neurodevelopmental-disorders-in-saudi-arabia-a-cross-sectional-study
#19
JOURNAL ARTICLE
Ali Jawad Al Saad, Ghadeer Mohammed Alhassan, Maryam Saleh Albedaiwi, Fatimah Fathi Alqattan, Fatimah Ali Alessa, Hawra Wasel Alabdulmohsen
BACKGROUND: Acceptance of COVID-19 vaccination was noticed to be less common among parents of children with autism spectrum disorder (ASD) and other neurodevelopmental disorders. This study aimed to explore the beliefs and willingness of parents of children with neurodevelopmental disorders about COVID-19 vaccine and understand how certain factors influencing the vaccine decision-making process differ between them and other parents' groups. METHODS: A cross-sectional study was conducted between August to November 2021...
June 26, 2023: BMC Public Health
https://read.qxmd.com/read/37323041/-the-impact-of-covid-19-according-to-people-in-care-at-fact-and-autism-teams-wave-1-and-2-and-omikron-wave
#20
JOURNAL ARTICLE
S Castelein, S Crutzen, I D C van Balkom, J Bruins
BACKGROUND: COVID-19 affected our collective well-being. Measures during a pandemic may disproportionately impact individuals with mental illness. AIM: To measure the impact of COVID-19 on clients of FACT and autism teams over three waves. METHOD: Through a digital questionnaire participants (wave 1: n=100; wave 2: n=150; Omikron wave: n=15) reported on: <br />1. mental health, 2. outpatient care experiences, 3. government measures and information services...
2023: Tijdschrift Voor Psychiatrie
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