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Natalia Brenda Fernández, Daniela Lorenzo, María Elisa Picco, Gastón Barbero, Leonardo Sebastián Dergan-Dylon, María Paula Marks, Hernán García-Rivello, Liliana Gimenez, Vivian Labovsky, Luca Grumolato, Pablo Lopez-Bergami
The Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) is primarily expressed by neural crest cells during embryogenesis. Following a complete downregulation after birth, ROR1 was shown to re-express in various types of cancers. Little is known about ROR1 expression and function in melanoma. Here we show that ROR1 is aberrantly expressed in both melanoma cell lines and tumors and that its expression associates with poor Post-Recurrence Survival of melanoma. Using gain- and loss-of-function approaches we found that ROR1 enhances both anchorage-dependent and -independent growth of melanoma cells...
November 2016: Molecular Carcinogenesis
Gonzalo Montalvo-Esquivel, José Gregorio Chanona-Vilchis, Angel Herrera-Gómez, Antelmo Abelardo Meneses-García, David Isla-Ortiz
BACKGROUND: The carcinosarcoma, or Mixed Mullerian Malign Tumors, represent 1% of malignant ovarian neoplasm, they are formed by a component epithelium and another mesenquimal malignant both. OBJECTIVE: Report the experience of the Ginecological Department of the Instituto Nacional de Cancerología (Mexico) in the treatment of patients with ovarian carcinosarcoma or primary malignant of the ovary. METHODS: A retrospective of 8 cases of carcinosarcoma primary of ovary at National Institute of Cancerology, from January, 2005 to December, 2008...
July 2014: Ginecología y Obstetricia de México
Hakan Guven, Bora Koc, Fazil Saglam, Irem Akin Bayram, Gokhan Adas
BACKGROUND: Unexpected inflammatory cecal masses of uncertain etiology, encountered in the emergency surgical departments can be indistinguishable, and appropriate operative management of these cases is a dilemma for the surgeons. METHODS: Over a 30-months period between January 2009 and June 2011, a series of 3032 patients who live in sub-urban underwent emergency surgery for clinical diagnosis of acute appendicitis and ileocecal resection or right hemicolectomy for inflammatory cecal mass were performed in 48 patients...
January 20, 2014: World Journal of Emergency Surgery: WJES
Alexander Lozano Samaniego, Yukiyosi Kimura Fujikami, Sergio Criales Vera, Miguel Stoopen Rometti
Intrapancreatic lipoma is a mesenquimal tumor that currently is still considered a strange entity. There are numerous hypotheses about its pathophysiology; however, none has been clarified. Diagnosis is usually incidental, and computed tomography has been performed for other indications, with high sensibility and specificity, making histopathology confirmation unnecessary, hence suggesting image-follow up solely.
September 2011: Gaceta Médica de México
P B Aleixo, A A Hartmann, I C Menezes, R T Meurer, A M Oliveira
BACKGROUND: Well differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS) have been shown to have supernumerary chromosomes with amplified sequences of the MDM2 and CDK4 genes. MDM2 and CDK4 protein overexpression have also been identified in these tumours. AIM: To investigate whether immunohistochemistry (IHC) for MDM2 and CDK4 can be used to diagnose WDLPS and DDLPS. METHODS: IHC for MDM2/CDK4 was carried out on a series of 129 paraffin-embedded lipomatous and non-lipomatous soft tissue tumours...
December 2009: Journal of Clinical Pathology
S Martín Martín, C Muller Arteaga, V Gonzalo Rodríguez, E García Lagarto, J Egea Camacho, E Fernández del Busto
Bladder hemangiomas are mesenquimal tumors, generally benign and of difficult diagnosis, representing only 0.6% primary bladder tumors. Fundamental diagnosis is histological, since imaging test can't differenciate this from other bladder tumors. We present a case of a 60-year-old male who came to our service with macroscopic hematuria. RTU of one blue mass in the bladder was performed and the histological examination showed to be cavernous hemangioma. A review of literature was realized, commenting on the most typical clinical aspects, the diagnostic methods and the last therapeutic techniques in this type of lesions...
November 2007: Actas Urologicas Españolas
L Xambre, R Lages, M Cerqueira, V Silva, R Prisco, R Santos, F Carreira, M Honavar
Solitary fibrous tumour is a well defined pathological entity originally described as a tumour of the pleura, but the occurrence of this neoplasm has increasingly been described at other sites. At present the development of these tumours is recognized as possible in virtually all anatomical sites. The rarity of this type of pathology has not allowed up to the present time clarification of the histogenesis, clinical behaviour, treatment and prognosis of these tumours. Differential diagnosis becomes important, especially in extra-thoracic sites so as not to mistake them for much more aggressive mesenquimal tumours...
November 2003: Actas Urologicas Españolas
Ricardo Silva Centeno, Alessandra Augusta Gorgulho Pedroso, Emilio Marcelo Pereira, Aziz Rassi Neto
The solitary fibrous tumor (SFT) is a rare mesenquimal neoplasm, found originally in association with the pleura. Recently, SFT was reported in others sites. The extension into adjacent structures is not uncommon. The meningeal involvement by SFT is rare and there has only twenty-six cases been reported previously in the literature. We report a case of a 25 years-old female patient with generalized tonic clonic seizures in the last six years. During the neurologic investigation, a tumor in the left occipital region of the brain was found...
June 2002: Arquivos de Neuro-psiquiatria
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