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https://www.readbyqxmd.com/read/29621258/diva-metabolomics-differentiating-vaccination-status-following-viral-challenge-using-metabolomic-profiles
#1
Darren W Gray, Michael D Welsh, Fawad Mansoor, Simon Doherty, Olivier P Chevallier, Christopher T Elliott, Mark H Mooney
Bovine Respiratory Disease (BRD) is a major source of economic loss within the agricultural industry. Vaccination against BRD-associated viruses does not offer complete immune protection and vaccine failure animals present potential routes for disease spread. Serological differentiation of infected from vaccinated animals (DIVA) is possible using antigen-deleted vaccines, but during virus outbreaks DIVA responses are masked by wild-type virus preventing accurate serodiagnosis. Previous work by the authors has established the potential for metabolomic profiling to reveal metabolites associated with systemic immune responses to vaccination...
2018: PloS One
https://www.readbyqxmd.com/read/29581547/protein-targeting-chimeric-molecules-specific-for-bromodomain-and-extra-terminal-motif-family-proteins-are-active-against-pre-clinical-models-of-multiple-myeloma
#2
Xiaohui Zhang, Hans C Lee, Fazal Shirazi, Veerabhadran Baladandayuthapani, Heather Lin, Isere Kuiatse, Hua Wang, Richard J Jones, Zuzana Berkova, Ram Kumar Singh, Jing Lu, Yimin Qian, Kanak Raina, Kevin G Coleman, Craig M Crews, Bingzong Li, Huihan Wang, Yared Hailemichael, Sheeba K Thomas, Zhiqiang Wang, R Eric Davis, Robert Z Orlowski
Bromodomain and extraterminal (BET) domain containing protein (BRD)-4 modulates the expression of oncogenes such as c-myc, and is a promising therapeutic target in diverse cancer types. We performed pre-clinical studies in myeloma models with bi-functional protein-targeting chimeric molecules (PROTACs) which target BRD4 and other BET family members for ubiquitination and proteasomal degradation. PROTACs potently reduced the viability of myeloma cell lines in a time-dependent and concentration-dependent manner associated with G0 /G1 arrest, reduced levels of CDKs 4 and 6, increased p21 levels, and induction of apoptosis...
March 27, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29576039/performance-health-and-physiological-responses-of-newly-weaned-feedlot-cattle-supplemented-with-feed-grade-antibiotics-or-alternative-feed-ingredients
#3
K A de Souza, R F Cooke, K M Schubach, A P Brandão, T F Schumaher, I N Prado, R S Marques, D W Bohnert
With increased regulations regarding the use of feed-grade antimicrobials in livestock systems, alternative strategies to enhance growth and immunity of feedlot cattle are warranted. Hence, this experiment compared performance, health and physiological responses of cattle supplemented with feed-grade antibiotics or alternative feed ingredients during the initial 60 days in the feedlot. Angus×Hereford calves (63 steers+42 heifers) originating from two cow-calf ranches were weaned on day -3, obtained from an auction yard on day -2 and road-transported (800 km; 12 h) to the feedlot...
March 26, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29567837/the-brd3-et-domain-recognizes-a-short-peptide-motif-through-a-mechanism-that-is-conserved-across-chromatin-remodelers-and-transcriptional-regulators
#4
Dorothy C Wai, Taylor N Szyszka, Amy E Campbell, Cherry Kwong, Lorna E Wilkinson-White, Ana P G Silva, Jason K K Low, Ann H Kwan, Roland Gamsjaeger, James N Chalmers, Wayne M Patrick, Bin Lu, Christopher R Vakoc, Gerd Blobel, Joel P Mackay
Members of the bromodomain and extra-terminal domain (BET) family of proteins (bromodomain-containing (BRD) 2, 3, 4 and T) are widely expressed and highly conserved regulators of gene expression in eukaryotes. These proteins have been intimately linked to human disease and more than a dozen clinical trials are currently underway to test BET-protein inhibitors as modulators of cancer therapies. However, although it is clear that these proteins use their bromodomains to bind both histones and transcription factors bearing acetylated lysine residues, the molecular mechanisms by which BET-family proteins regulate gene expression are not well defined...
March 22, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29561307/synergistic-in-vitro-effects-of-combining-an-antiglycolytic-3-bromopyruvate-and-a-bromodomain-4-inhibitor-on-u937-myeloid-leukemia-cells
#5
Nicolette Kapp, Xiao X Stander, Barend A Stander
This project investigated the in-vitro effects of a glycolytic inhibitor, 3-bromopyruvate (3-BrP), in combination with and a new in silico-designed inhibitor of the bromodomain-4 (BRD-4) protein, ITH-47, on the U937 acute myeloid leukemia cell line. 3-BrP is an agent that targets the altered metabolism of cancer cells by interfering with glucose metabolism in the glycolytic pathway. ITH-47 is an acetyl-lysine inhibitor that displaces bromdomain 4 proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of this bromodomain and extraterminal (BET) BRD protein, thereby preventing transcription of cancer-associated genes and further cell growth...
March 20, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29525311/the-effect-of-lung-consolidation-as-determined-by-ultrasonography-on-first-lactation-milk-production-in-holstein-dairy-calves
#6
T R Dunn, T L Ollivett, D L Renaud, K E Leslie, S J LeBlanc, T F Duffield, D F Kelton
Bovine respiratory disease (BRD) is a complex disease process and many reports emphasize the negative implications of clinical BRD in dairy calves. Early diagnosis can be difficult because of inconsistent or absent clinical signs; however, the use thoracic ultrasonography has the potential to improve detection of respiratory disease. Earlier detection of BRD may result in actions to improve calf welfare and production. The objective of this prospective cohort study was to determine if lung consolidation (LC) in young dairy calves influenced age at first calving (AFC), first-lactation milk production, and survival to the end of first lactation...
March 7, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29523178/the-bromodomain-containing-protein-ibd1-links-multiple-chromatin-related-protein-complexes-to-highly-expressed-genes-in-tetrahymena-thermophila
#7
Alejandro Saettone, Jyoti Garg, Jean-Philippe Lambert, Syed Nabeel-Shah, Marcelo Ponce, Alyson Burtch, Cristina Thuppu Mudalige, Anne-Claude Gingras, Ronald E Pearlman, Jeffrey Fillingham
BACKGROUND: The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attributed to SNF2/Brg1. RESULTS: Using affinity purification coupled to mass spectrometry (AP-MS) we identified members of a SWI/SNF complex (SWI/SNFTt ) in Tetrahymena thermophila. SWI/SNFTt is composed of 11 proteins, Snf5Tt , Swi1Tt , Swi3Tt , Snf12Tt , Brg1Tt , two proteins with potential chromatin-interacting domains and four proteins without orthologs to SWI/SNF proteins in yeast or mammals...
March 9, 2018: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29515533/-vibrio-tapetis-displays-an-original-type-iv-secretion-system-in-strains-pathogenic-for-bivalve-molluscs
#8
Graciela M Dias, Adeline Bidault, Patrick Le Chevalier, Gwenaëlle Choquet, Clio Der Sarkissian, Ludovic Orlando, Claudine Medigue, Valerie Barbe, Sophie Mangenot, Cristiane C Thompson, Fabiano L Thompson, Annick Jacq, Vianney Pichereau, Christine Paillard
The Brown Ring Disease (BRD) caused high mortality rates since 1986 in the Manila clam Venerupis philippinarum introduced and cultured in Western Europe from the 1970s. The causative agent of BRD is a Gram-Negative bacterium, Vibrio tapetis , which is also pathogenic to fish. Here we report the first assembly of the complete genome of V. tapetis CECT4600T , together with the genome sequences of 16 additional strains isolated across a broad host and geographic range. Our extensive genome dataset allowed us to describe the pathogen pan- and core genomes and to identify putative virulence factors...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29483155/a-mechanism-for-epigenetic-control-of-dna-replication
#9
Courtney G Sansam, Katarzyna Pietrzak, Blanka Majchrzycka, Maciej A Kerlin, Jingrong Chen, Susannah Rankin, Christopher L Sansam
DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication. Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4. Abrogation of this interaction impairs TICRR binding to acetylated chromatin and disrupts normal S-phase progression...
February 1, 2018: Genes & Development
https://www.readbyqxmd.com/read/29482563/risk-factors-associated-with-exposure-to-bovine-respiratory-disease-pathogens-during-the-peri-weaning-period-in-dairy-bull-calves
#10
Gerard M Murray, Simon J More, Tracy A Clegg, Bernadette Earley, Rónan G O'Neill, Dayle Johnston, John Gilmore, Mikhail Nosov, Máire C McElroy, Thomas J Inzana, Joseph P Cassidy
BACKGROUND: Bovine respiratory disease (BRD) remains among the leading causes of death of cattle internationally. The objective of this study was to identify risk factors associated with exposure to BRD pathogens during the peri-weaning period (day (d)-14 to d 14 relative to weaning at 0) in dairy bull calves using serological responses to these pathogens as surrogate markers of exposure. Clinically normal Holstein-Friesian and Jersey breed bull calves (n = 72) were group housed in 4 pens using a factorial design with calves of different breeds and planes of nutrition in each pen...
February 27, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29481657/applying-definitions-for-multidrug-resistance-extensive-drug-resistance-and-pandrug-resistance-to-clinically-significant-livestock-and-companion-animal-bacterial-pathogens
#11
Michael T Sweeney, Brian V Lubbers, Stefan Schwarz, Jeffrey L Watts
Standardized definitions for MDR are currently not available in veterinary medicine despite numerous reports indicating that antimicrobial resistance may be increasing among clinically significant bacteria in livestock and companion animals. As such, assessments of MDR presented in veterinary scientific reports are inconsistent. Herein, we apply previously standardized definitions for MDR, XDR and pandrug resistance (PDR) used in human medicine to animal pathogens and veterinary antimicrobial agents in which MDR is defined as an isolate that is not susceptible to at least one agent in at least three antimicrobial classes, XDR is defined as an isolate that is not susceptible to at least one agent in all but one or two available classes and PDR is defined as an isolate that is not susceptible to all agents in all available classes...
February 22, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29471391/comparative-efficacy-of-enrofloxacin-to-that-of-tulathromycin-for-the-control-of-bovine-respiratory-disease-and-prevalence-of-antimicrobial-resistance-in-mannheimia-haemolytica-in-calves-at-high-risk-of-developing-bovine-respiratory-disease
#12
S Crosby, B Credille, S Giguère, R Berghaus
Bovine respiratory disease (BRD) is the most common cause of morbidity and mortality in North American beef cattle. Mannheimia haemolytica (Mh) is the bacterial pathogen most often isolated from cattle with BRD and the prevalence of antimicrobial resistance (AMR) in this organism has increased in recent years. Antimicrobials are commonly used to prevent BRD in cattle at high-risk of developing BRD, however, recent work would suggest that this practice might be one factor contributing to the increased prevalence of AMR in Mh...
February 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29426400/role-of-the-stress-associated-chemicals-norepinephrine-epinephrine-and-substance-p-in-dispersal-of-mannheimia-haemolytica-from-biofilms
#13
Deepti K Pillai, Elva Cha, Derek Mosier
Bovine respiratory disease (BRD) is a major problem for the cattle industry that is triggered by various environmental stressors, pathogens and host responses. Mannheimia hemolytica, an important bacterial component of BRD, are present within the nasopharayngeal region of normal calves as commensal biofilm communities. However, following stress there are changes in the nasopharyngeal microenvironment that triggers the transition of the commensal M. haemolytica into a pulmonary pathogen. The factors responsible for this transition in- vivo are unknown...
February 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29408026/injectable-antimicrobials-in-commercial-feedlot-cattle-and-their-effect-on-the-nasopharyngeal-microbiota-and-antimicrobial-resistance
#14
Devin B Holman, Edouard Timsit, Calvin W Booker, Trevor W Alexander
Beef cattle in North America that are deemed to be at high risk of developing bovine respiratory disease (BRD) are frequently administered a metaphylactic antibiotic injection to control the disease. Cattle may also receive in-feed antimicrobials to prevent specific diseases and ionophores to improve growth and feed efficiency. Presently, attempts to evaluate the effects that these medications have on antibiotic resistance in the bovine nasopharyngeal microbiota have been focused on culturable bacteria that are associated with BRD...
February 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29406078/the-reporting-characteristics-of-bovine-respiratory-disease-clinical-intervention-trials-published-prior-to-and-following-publication-of-the-reflect-statement
#15
Sarah C Totton, Jonah N Cullen, Jan M Sargeant, Annette M O'Connor
The goal of the REFLECT Statement (Reporting guidElines For randomized controLled trials in livEstoCk and food safeTy) (published in 2010) was to provide the veterinary research community with reporting guidelines tailored for randomized controlled trials for livestock and food safety. Our objective was to determine the prevalence of REFLECT Statement reporting of items 1-19 in controlled trials published in journals between 1970 and 2017 examining the comparative efficacy of FDA-registered antimicrobials against naturally acquired BRD (bovine respiratory disease) in weaned beef calves in Canada or the USA, and to compare the prevalence of reporting before and after 2010, when REFLECT was published...
February 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29399399/bromodomain-inhibition-exerts-its-therapeutic-potential-in-malignant-pleural-mesothelioma-by-promoting-immunogenic-cell-death-and-changing-the-tumor-immune-environment
#16
Chiara Riganti, Marcello Francesco Lingua, Iris Chiara Salaroglio, Chiara Falcomatà, Luisella Righi, Deborah Morena, Francesca Picca, Daniele Oddo, Joanna Kopecka, Monica Pradotto, Roberta Libener, Sara Orecchia, Paolo Bironzo, Valentina Comunanza, Federico Bussolino, Silvia Novello, Giorgio Vittorio Scagliotti, Federica Di Nicolantonio, Riccardo Taulli
Systemic treatment of malignant pleural mesothelioma (MPM) is moderately active for the intrinsic pharmacological resistance of MPM cell and its ability to induce an immune suppressive environment. Here we showed that the expression of bromodomain (BRD) proteins BRD2, BRD4 and BRD9 was significantly higher in human primary MPM cells compared to normal mesothelial cells (HMC). Nanomolar concentrations of bromodomain inhibitors (BBIs) JQ1 or OTX015 impaired patient-derived MPM cell proliferation and induced cell-cycle arrest without affecting apoptosis...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29377356/efficacy-of-oral-administration-of-sodium-iodide-to-prevent-bovine-respiratory-disease-complex
#17
B M Shoemake, B L Vander Ley, B W Newcomer, M C Heller
BACKGROUND: The prevention of bovine respiratory disease complex (BRD) in beef cattle is important to maintaining health and productivity of calves in feeding operations. OBJECTIVE: Determine whether BRD bacterial and viral pathogens are susceptible to the lactoperoxidase/hydrogen peroxide/iodide (LPO/H2 O2 /I- ) system in vitro and to determine whether the oral administration of sodium iodide (NaI) could achieve sufficient concentrations of iodine (I) in the respiratory secretions of weaned beef calves to inactivate these pathogens in vivo...
January 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29330058/haptoglobin-and-serum-amyloid-a-as-putative-biomarker-candidates-of-naturally-occurring-bovine-respiratory-disease-in-dairy-calves
#18
Vivek Joshi, V K Gupta, A G Bhanuprakash, R S K Mandal, U Dimri, Y Ajith
Bovine respiratory disease (BRD) is one of the leading causes of morbidity and mortality in dairy calves. Identification of reliable biomarkers of naturally occurring BRD is essential for ensuring early diagnosis and treatment of calves and monitoring treatment efficacy. This need is punctuated, especially in mild to moderate cases that would greatly help to decrease recurrence and the overall prevalence of BRD. The present study was conducted to investigate the changes in serum concentrations of haptoglobin (Hpt) and serum amyloid A (SAA) and association between oxidative stress and acute phase proteins (APPs) in BRD...
March 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29329830/theoretical-research-in-structure-characteristics-of-different-inhibitors-and-differences-of-binding-modes-with-cbp-bromodomain
#19
Xue-Song Wang, Qing-Chuan Zheng
The CBP (CREB (cAMP responsive element binding protein) binding protein) bromodomain (BRD) could recognize and bind with acetyl K382 of human tumor suppressor protein p53 which the mutation of encoding gene might cause human cancers. CBP-BRD serves as a promising drug target for several disease pathways and a series of effective drug have been discovered. In this study, molecular dynamics (MD) simulations and molecular mechanics generalized born surface area (MM-GB/SA) approaches were performed to investigate the different binding modes between five inhibitors with CBP-BRD...
February 1, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29290447/herd-level-prevalence-of-the-ultrasonographic-lung-lesions-associated-with-bovine-respiratory-disease-and-related-environmental-risk-factors
#20
S Buczinski, M E Borris, J Dubuc
Bovine respiratory disease complex (BRD) is a major calf disease during the preweaning period. Thoracic ultrasound (TUS) has been recently described as a reliable tool for assessing BRD-associated lung lesions. The objectives of this study were to define the herd-level prevalence of lung consolidation assessed by TUS (CONSTUS). A total of 39 Québec dairy herds were randomly chosen to participate in this cross-sectional study. Between 6 and 12 preweaned calves were examined for signs of CONSTUS defined by any site with ≥3 cm consolidated lung tissue during 1 visit in summer and 1 visit in winter...
March 2018: Journal of Dairy Science
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