keyword
MENU ▼
Read by QxMD icon Read
search

BRD

keyword
https://www.readbyqxmd.com/read/29426400/role-of-the-stress-associated-chemicals-norepinephrine-epinephrine-and-substance-p-in-dispersal-of-mannheimia-haemolytica-from-biofilms
#1
Deepti K Pillai, Elva Cha, Derek Mosier
Bovine respiratory disease (BRD) is a major problem for the cattle industry that is triggered by various environmental stressors, pathogens and host responses. Mannheimia hemolytica, an important bacterial component of BRD, are present within the nasopharayngeal region of normal calves as commensal biofilm communities. However, following stress there are changes in the nasopharyngeal microenvironment that triggers the transition of the commensal M. haemolytica into a pulmonary pathogen. The factors responsible for this transition in- vivo are unknown...
February 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29408026/injectable-antimicrobials-in-commercial-feedlot-cattle-and-their-effect-on-the-nasopharyngeal-microbiota-and-antimicrobial-resistance
#2
Devin B Holman, Edouard Timsit, Calvin W Booker, Trevor W Alexander
Beef cattle in North America that are deemed to be at high risk of developing bovine respiratory disease (BRD) are frequently administered a metaphylactic antibiotic injection to control the disease. Cattle may also receive in-feed antimicrobials to prevent specific diseases and ionophores to improve growth and feed efficiency. Presently, attempts to evaluate the effects that these medications have on antibiotic resistance in the bovine nasopharyngeal microbiota have been focused on culturable bacteria that are associated with BRD...
February 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29406078/the-reporting-characteristics-of-bovine-respiratory-disease-clinical-intervention-trials-published-prior-to-and-following-publication-of-the-reflect-statement
#3
Sarah C Totton, Jonah N Cullen, Jan M Sargeant, Annette M O'Connor
The goal of the REFLECT Statement (Reporting guidElines For randomized controLled trials in livEstoCk and food safeTy) (published in 2010) was to provide the veterinary research community with reporting guidelines tailored for randomized controlled trials for livestock and food safety. Our objective was to determine the prevalence of REFLECT Statement reporting of items 1-19 in controlled trials published in journals between 1970 and 2017 examining the comparative efficacy of FDA-registered antimicrobials against naturally acquired BRD (bovine respiratory disease) in weaned beef calves in Canada or the USA, and to compare the prevalence of reporting before and after 2010, when REFLECT was published...
February 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29399399/bromodomain-inhibition-exerts-its-therapeutic-potential-in-malignant-pleural-mesothelioma-by-promoting-immunogenic-cell-death-and-changing-the-tumor-immune-environment
#4
Chiara Riganti, Marcello Francesco Lingua, Iris Chiara Salaroglio, Chiara Falcomatà, Luisella Righi, Deborah Morena, Francesca Picca, Daniele Oddo, Joanna Kopecka, Monica Pradotto, Roberta Libener, Sara Orecchia, Paolo Bironzo, Valentina Comunanza, Federico Bussolino, Silvia Novello, Giorgio Vittorio Scagliotti, Federica Di Nicolantonio, Riccardo Taulli
Systemic treatment of malignant pleural mesothelioma (MPM) is moderately active for the intrinsic pharmacological resistance of MPM cell and its ability to induce an immune suppressive environment. Here we showed that the expression of bromodomain (BRD) proteins BRD2, BRD4 and BRD9 was significantly higher in human primary MPM cells compared to normal mesothelial cells (HMC). Nanomolar concentrations of bromodomain inhibitors (BBIs) JQ1 or OTX015 impaired patient-derived MPM cell proliferation and induced cell-cycle arrest without affecting apoptosis...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29377356/efficacy-of-oral-administration-of-sodium-iodide-to-prevent-bovine-respiratory-disease-complex
#5
B M Shoemake, B L Vander Ley, B W Newcomer, M C Heller
BACKGROUND: The prevention of bovine respiratory disease complex (BRD) in beef cattle is important to maintaining health and productivity of calves in feeding operations. OBJECTIVE: Determine whether BRD bacterial and viral pathogens are susceptible to the lactoperoxidase/hydrogen peroxide/iodide (LPO/H2 O2 /I- ) system in vitro and to determine whether the oral administration of sodium iodide (NaI) could achieve sufficient concentrations of iodine (I) in the respiratory secretions of weaned beef calves to inactivate these pathogens in vivo...
January 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29330058/haptoglobin-and-serum-amyloid-a-as-putative-biomarker-candidates-of-naturally-occurring-bovine-respiratory-disease-in-dairy-calves
#6
Vivek Joshi, V K Gupta, A G Bhanuprakash, R S K Mandal, U Dimri, Y Ajith
Bovine respiratory disease (BRD) is one of the leading causes of morbidity and mortality in dairy calves. Identification of reliable biomarkers of naturally occurring BRD is essential for ensuring early diagnosis and treatment of calves and monitoring treatment efficacy. This need is punctuated, especially in mild to moderate cases that would greatly help to decrease recurrence and the overall prevalence of BRD. The present study was conducted to investigate the changes in serum concentrations of haptoglobin (Hpt) and serum amyloid A (SAA) and association between oxidative stress and acute phase proteins (APPs) in BRD...
January 9, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29329830/theoretical-research-in-structure-characteristics-of-different-inhibitors-and-differences-of-binding-modes-with-cbp-bromodomain
#7
Xue-Song Wang, Qing-Chuan Zheng
The CBP (CREB (cAMP responsive element binding protein) binding protein) bromodomain (BRD) could recognize and bind with acetyl K382 of human tumor suppressor protein p53 which the mutation of encoding gene might cause human cancers. CBP-BRD serves as a promising drug target for several disease pathways and a series of effective drug have been discovered. In this study, molecular dynamics (MD) simulations and molecular mechanics generalized born surface area (MM-GB/SA) approaches were performed to investigate the different binding modes between five inhibitors with CBP-BRD...
December 26, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29290447/herd-level-prevalence-of-the-ultrasonographic-lung-lesions-associated-with-bovine-respiratory-disease-and-related-environmental-risk-factors
#8
S Buczinski, M E Borris, J Dubuc
Bovine respiratory disease complex (BRD) is a major calf disease during the preweaning period. Thoracic ultrasound (TUS) has been recently described as a reliable tool for assessing BRD-associated lung lesions. The objectives of this study were to define the herd-level prevalence of lung consolidation assessed by TUS (CONSTUS). A total of 39 Québec dairy herds were randomly chosen to participate in this cross-sectional study. Between 6 and 12 preweaned calves were examined for signs of CONSTUS defined by any site with ≥3 cm consolidated lung tissue during 1 visit in summer and 1 visit in winter...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29290433/associations-between-management-practices-and-within-pen-prevalence-of-calf-diarrhea-and-respiratory-disease-on-dairy-farms-using-automated-milk-feeders
#9
Catalina Medrano-Galarza, Stephen J LeBlanc, Andria Jones-Bitton, Trevor J DeVries, Jeffrey Rushen, Anne Marie de Passillé, Marcia I Endres, Derek B Haley
Data on management practices used with automated milk feeders (AMF) are needed to identify factors associated with calf health in these systems. The objectives of this observational, longitudinal, cross-sectional study were to estimate the prevalence of calf diarrhea (CD) and bovine respiratory disease (BRD), and to identify factors associated with prevalence of these diseases at the pen level on dairy farms feeding milk to group-housed calves with AMF. Seventeen dairy farms with AMF in Ontario, Canada, were visited 4 times, seasonally, over 1 yr...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29277170/supplementing-a-yeast-derived-product-to-enhance-productive-and-health-responses-of-beef-steers
#10
L G T Silva, R F Cooke, K M Schubach, A P Brandão, R S Marques, T F Schumaher, P Moriel, D W Bohnert
This experiment evaluated the impacts of supplementing a yeast-derived product (Celmanax; Church & Dwight Co., Inc., Princeton, NJ, USA) on productive and health responses of beef steers, and was divided into a preconditioning (days 4 to 30) and feedlot receiving phase (days 31 to 69). In all, 84 Angus × Hereford steers were weaned on day 0 (BW=245±2 kg; age=186±2 days), and maintained in a single group from days 0 to 3. On day 4, steers were allocated according to weaning BW and age to a 21-pen drylot (4 steers/pen)...
December 26, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29259784/prospective-cohort-study-to-assess-rates-of-contagious-disease-in-pre-weaned-uk-dairy-heifers-management-practices-passive-transfer-of-immunity-and-associated-calf-health
#11
Kate F Johnson, Natalie Chancellor, Charlotte C Burn, D Claire Wathes
Dairy calves are vulnerable to infectious diseases, particularly diarrhoea and bovine respiratory disease (BRD), causing mortality and reducing welfare and growth. A prospective cohort study was performed on 11 UK dairy farms to determine the underlying causes for calf disease. This first paper describes the incidence, timing and duration of infectious disease, mortality rates, passive transfer of immunity and key management practices that may contribute to disease incidence. Heifer calves were recruited in the first week of life (n=492) and a blood sample taken to measure IgG and total protein (TP)...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/29228881/unravelling-novel-congeners-from-acetyllysine-mimicking-ligand-targeting-a-lysine-acetyltransferase-pcaf-bromodomain
#12
Venkatesan Suryanarayanan, Sanjeev Kumar Singh
p300/CBP Associated Factor (PCAF) bromodomain (BRD), a lysine acetyltransferases, has emerged as a promising drug target as its dysfunction is linked to onset and progression of several diseases like cancer, diabetes, AIDS etc. In this study, a three featured E-Pharmacophore (ARR) was generated based on acetyllysine mimicking inhibitor of PCAF BRD which is available as co-crystal structure (PDB ID: 5FDZ). It was used for filtering small molecule databases followed by molecular docking and consequently validated using enrichment calculation...
December 11, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29206855/linking-disease-epidemiology-and-livestock-productivity-the-case-of-bovine-respiratory-disease-in-france
#13
Alexis Delabouglise, Andrew James, Jean-François Valarcher, Sara Hagglünd, Didier Raboisson, Jonathan Rushton
Concerns are growing over the impact of livestock farming on environment and public health. The livestock industry is faced with the double constraint of limiting its use of natural resources and antimicrobials while ensuring its economic sustainability. In this context, reliable methods are needed to evaluate the effect of the prevention of endemic animal diseases on the productivity of livestock production systems. In this study, an epidemiological and productivity model was used to link changes in Bovine Respiratory Disease (BRD) incidence with the productivity of the beef and dairy cattle sectors in France...
2017: PloS One
https://www.readbyqxmd.com/read/29197695/probing-numerical-laplace-inversion-methods-for-two-and-three-site-molecular-exchange-between-interconnected-pore-structures
#14
Emilia V Silletta, María B Franzoni, Gustavo A Monti, Rodolfo H Acosta
Two-dimension (2D) Nuclear Magnetic Resonance relaxometry experiments are a powerful tool extensively used to probe the interaction among different pore structures, mostly in inorganic systems. The analysis of the collected experimental data generally consists of a 2D numerical inversion of time-domain data where T2-T2 maps are generated. Through the years, different algorithms for the numerical inversion have been proposed. In this paper, two different algorithms for numerical inversion are tested and compared under different conditions of exchange dynamics; the method based on Butler-Reeds-Dawson (BRD) algorithm and the fast-iterative shrinkage-thresholding algorithm (FISTA) method...
November 30, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29189147/disrupting-acetyl-lysine-interactions-recent-advance-in-the-development-of-bet-inhibitors
#15
Fa Zhang, Shutao Ma
BACKGROUND: Histone acetylation is an essential way of post-translational modification (PTM) and a significant component of epigenetic regulation that is mediated by Bromodomain-containing protein (BRD). In recent years, many researchers have found that a variety of malignancy, inflammatory and other diseases occurrence and development are associated with BRD4 expression disorders or dysfunction. Meanwhile, many the bromodomain inhibitors of the bromodomains and extra-terminal (BET) family is reported in many papers...
November 29, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29185614/permanent-pacing-after-transcatheter-aortic-valve-implantation-incidence-predictors-and-evolution-of-left-ventricular-function
#16
Cláudio Monteiro, Andres Di Leoni Ferrari, Paulo Ricardo Avancini Caramori, Luiz Antonio Ferreira Carvalho, Dimytri Alexandre de Alvim Siqueira, Luiz Eduardo Koenig São Thiago, Marco Perin, Valter C de Lima, Enio Guérios, Fabio Sandoli De Brito
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a well-established procedure; however, atrioventricular block requiring permanent pacemaker implantation (PPI) is a common complication. OBJECTIVES: To determine the incidence, predictors and clinical outcomes of PPI after TAVI, focusing on how PPI affects left ventricular ejection fraction (LVEF) after TAVI. METHODS: The Brazilian Multicenter TAVI Registry included 819 patients submitted to TAVI due to severe aortic stenosis from 22 centers from January/2008 to January/2015...
November 27, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29180474/vitamin-c-sensitizes-melanoma-to-bet-inhibitors
#17
Sushmita Mustafi, Vladimir Camarena, Claude-Henry Volmar, Tyler C Huff, David W Sant, Shaun P Brothers, Zhao-Jun Liu, Claes Wahlestedt, Gaofeng Wang
Bromodomain and extraterminal inhibitors (BETi) are promising cancer therapies, yet prominent side effects of BETi at effective doses have been reported in phase I clinical trials. Here, we screened a panel of small molecules targeting epigenetic modulators against human metastatic melanoma cells. Cells were pretreated with or without ascorbate (vitamin C), which promotes DNA demethylation and subsequently changes the sensitivity to drugs. Top hits were structurally unrelated BETi, including JQ1, I-BET151, CPI-203, and BI-2536...
January 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29170739/market-impacts-of-reducing-the-prevalence-of-bovine-respiratory-disease-in-united-states-beef-cattle-feedlots
#18
Kamina Keiko Johnson, Dustin L Pendell
Bovine respiratory disease (BRD) is a common endemic disease among North American feedlot cattle. BRD can lead to significant economic losses for individual beef cattle feedlot producers through mortality and morbidity. With promising new management and technology research that could reduce BRD prevalence, this study evaluates the potential impacts of a reduction of BRD in the US beef cattle feedlot sector. Using a multi-market, multi-commodity partial equilibrium economic model of the US agricultural industry, we evaluate the market impacts of reduced BRD to producers from various livestock, meat, and feedstuffs industries...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29166709/-effects-of-dexmedetomidine-on-myocardium-of-rats-with-severe-burn-at-early-stage
#19
D Wang, P L Yang, X Zhang, Y Liu
Objective: To investigate the effects of dexmedetomidine on myocardium of rats at early stage after severe burn. Methods: Twenty specific pathogen free male SD rats were immersed in 90 ℃ hot water for 20 s, causing 30% total body surface area (TBSA) full-thickness scald (hereafter referred to as burn) on the back. And then they were divided into burn resuscitation group (BR) and burn resuscitation+ dexmedetomidine group (BRD) according to the random number table, with 10 rats in each group. Sodium lactate Ringer's solution (2 mL·kg(-1)·%TBSA(-1)) were intraperitoneally injected into rats of both groups after burn...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29150614/spatial-regulation-of-contractility-by-neuralized-and-bearded-during-furrow-invagination-in-drosophila
#20
Gantas Perez-Mockus, Khalil Mazouni, Vanessa Roca, Giulia Corradi, Vito Conte, François Schweisguth
Embryo-scale morphogenesis arises from patterned mechanical forces. During Drosophila gastrulation, actomyosin contractility drives apical constriction in ventral cells, leading to furrow formation and mesoderm invagination. It remains unclear whether and how mechanical properties of the ectoderm influence this process. Here, we show that Neuralized (Neur), an E3 ubiquitin ligase active in the mesoderm, regulates collective apical constriction and furrow formation. Conversely, the Bearded (Brd) proteins antagonize maternal Neur and lower medial-apical contractility in the ectoderm: in Brd-mutant embryos, the ventral furrow invaginates properly but rapidly unfolds as medial MyoII levels increase in the ectoderm...
November 17, 2017: Nature Communications
keyword
keyword
58166
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"