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https://www.readbyqxmd.com/read/28736341/tfos-dews-ii-iatrogenic-report
#1
REVIEW
José Alvaro P Gomes, Dimitri T Azar, Christophe Baudouin, Nathan Efron, Masatoshi Hirayama, Jutta Horwath-Winter, Terry Kim, Jodhbir S Mehta, Elisabeth M Messmer, Jay S Pepose, Virender S Sangwan, Alan L Weiner, Steven E Wilson, James S Wolffsohn
Dry eye can be caused by a variety of iatrogenic interventions. The increasing number of patients looking for eye care or cosmetic procedures involving the eyes, together with a better understanding of the pathophysiological mechanisms of dry eye disease (DED), have led to the need of a specific report about iatrogenic dry eye within the TFOS DEWS II. Topical medications can cause DED due to their allergic, toxic and immuno-inflammatory effects on the ocular surface. Preservatives, such as benzalkonium chloride, may further aggravate DED...
May 5, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28735120/outpatient-lumbar-microdiscectomy-in-france-from-an-economic-imperative-to-a-clinical-standard-an-observational-study-of-201-cases
#2
Bertrand Debono, Pascal Sabatier, Valérie Garnault, Olivier Hamel, Philippe Bousquet, Jean-Paul Lescure, Jean-Yves Plas
PURPOSE: The outpatient lumbar discectomy procedures have been established for more than two decades. However, especially in Europe, there are still obstacles to the development of these procedures, which may be related to medico-economic imperatives, and to several factors concerning both surgeons and patients. We describe our initial experience in introducing this method in our institution. METHODS: Over a three year period, 201 patients met the criteria for ambulatory lumbar microdiscectomy...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28734985/safety-of-catheter-ablation-for-atrial-fibrillation-using-fiber-optic-based-contact-force-sensing
#3
Moussa Mansour, Dhanunjaya Lakkireddy, Douglas Packer, John D Day, Srijoy Mahapatra, Kyle Brunner, Vivek Reddy, Andrea Natale
BACKGROUND: While the body of evidence showing the benefit of contact force (CF) sensing catheters in improving AF ablation success rate is growing, real-world safety data of this technology are limited. OBJECTIVE: The aim of this study is to report the complication rate in patients undergoing ablation using one specific CF sensing catheter (TactiCath™Quartz Contact Force Ablation Catheter (Abbott, St Paul, MN)) in a large worldwide database. METHODS: - User-reported adverse event data from January 2014 - December 2015 was reviewed for the ablation catheter...
July 19, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28734140/deregulation-of-levels-of-angiopoietin-1-and-angiopoietin-2-is-associated-with-severe-courses-of-hantavirus-infection
#4
Christian Nusshag, Anja Osberghaus, Alexandra Baumann, Paul Schnitzler, Martin Zeier, Ellen Krautkrämer
BACKGROUND: Hantavirus disease is characterized by endothelial dysfunction. Angiopoietin-1 (Ang-1) and its antagonist angiopoietin-2 (Ang-2) play a key role in the control of capillary permeability. Ang-1 is responsible for maintenance of cell-to-cell contacts whereas Ang-2 destabilizes monolayers. An imbalance of Ang-1 and Ang-2 levels results in enhanced permeability and capillary leakage. OBJECTIVES: To analyze the involvement of angiopoietins in hantavirus-induced disruption of endothelia, we measured the levels of Ang-1 and Ang-2 in hantavirus infection...
July 11, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28733272/adherence-to-web-based-self-assessments-in-long-term-direct-to-patient-research-two-year-study-of-multiple-sclerosis-patients
#5
Peter Joseph Jongen, Ingrid E H Kremer, Elena Hristodorova, Silvia M A A Evers, Anton Kool, Esther M van Noort, Mickaël Hiligsmann
BACKGROUND: Direct-to-patient research via Web-based questionnaires is increasingly being used. Missed data or delayed reporting of data may negatively affect the quality of study results. It is insufficiently known to what degree patients adhere to agreed self-assessment schedule over the long term and whether questionnaires are filled out in a timely manner. OBJECTIVE: The objective of this study was to investigate patients' adherence to a self-assessment schedule with low-frequency long questionnaires versus that with a high-frequency short questionnaire...
July 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28728926/diagnostic-delays-in-537-symptomatic-cases-of-mers-cov-infection-in-saudi-arabia
#6
Anwar E Ahmed
BACKGROUND: Although the literature indicates the potential outcomes of a patient's delay in seeking medical support is associated with poor clinical outcomes, delays in the diagnosis itself remain poorly understood in patients with Middle East Respiratory Syndrome - Coronavirus (MERS-CoV). This study aims to estimate the median time interval of confirmed diagnosis after symptom onset and identify its potential predictors in Saudi Arabian MERS patients. METHODS: A retrospective study involved patients confirmed with MERS who were publicly reported by the World Health Organization (WHO)...
July 17, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28728078/femoral-head-necrosis-a-finite-element-analysis-of-common-and-novel-surgical-techniques
#7
Myriam Cilla, Sara Checa, Bernd Preininger, Tobias Winkler, Carsten Perka, Georg N Duda, Matthias Pumberger
BACKGROUND: Femoral head necrosis is a common cause of secondary osteoarthritis. At the early stages, treatment strategies are normally based on core decompression techniques, where the number, location and diameter of the drilling holes varies depending on the selected approach. The purpose of this study was to investigate the risk of femoral head, neck and subtrochanteric fracture following six different core decompression techniques. MATERIALS: Five common and a newly proposed techniques were analyzed in respect to their biomechanical consequences using finite element analysis...
July 6, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28720474/nitrous-oxide-cryotherapy-for-treatment-of-esophageal-squamous-cell-neoplasia-initial-multicenter-international-experience-with-a-novel-portable-cryoballoon-ablation-system-with-video
#8
Marcia Irene Canto, Julian Abrams, Hannah Kunzli, Bas Weusten, Yoshihiro Komatsu, Blair Jobe, Charles J Lightdale
BACKGROUND AND AIMS: Early esophageal squamous cell neoplasia (ESCN) can be successfully treated by endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or radiofrequency ablation (RFA). A new portable, battery-powered cryotherapy system using nitrous oxide (cryoballoon focal ablation system (CbFAS) has been used for Barrett's esophagus. It consists of a small hand-held device containing liquid nitrous oxide, which converts to gas within a low-pressure-compliant through-the-scope balloon and freezes targeted mucosa in contact with the balloon...
July 15, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28720199/a-national-survey-exploring-uk-trainees-perceptions-core-training-experience-and-decisions-to-pursue-advanced-training-in-breast-radiology
#9
S Lowes, M Bydder, R Sinnatamby
AIM: To investigate UK radiology trainees' perceptions of breast radiology and the factors that influenced their decision whether or not to choose breast radiology as an area of special interest. MATERIALS & METHODS: An online survey was compiled and distributed to all UK specialty trainees in clinical radiology via the Royal College of Radiologists Junior Radiologists' Forum (JRF) regional representatives. RESULTS: There were 275 respondents, representing 22% of all UK radiology trainees...
July 15, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28718321/breathlessness-services-as-a-new-model-of-support-for-patients-with-respiratory-disease
#10
Claudia Bausewein, Michaela Schunk, Philipp Schumacher, Julika Dittmer, Anna Bolzani, Sara Booth
The complexity of breathlessness in advanced disease requires a diversity of measures ideally tailored to the individual patient needs. 'Breathlessness services' have been systematically developed and tested to provide specific interventions and support for patients and their carers. The aim of this article is (1) to identify and describe components of breathlessness services and (2) to describe the clinical model of one specific service in more detail. This article is based on a systematic review evaluating randomized controlled trials (RCTs) and quasi-RCTs which examine the effectiveness of services aiming to improve breathlessness of patients with advanced disease...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28716580/-determination-of-prognostic-value-to-6-months-of-oesil-risk-score-in-a-colombian-cohort-with-syncope-evaluated-in-the-emergency-department-first-latin-american-experience
#11
Diana Carolina Díaz-Tribaldos, Guillermo Mora, Alejandro Olaya, Jorge Marín, Fabio Sierra Matamoros
OBJECTIVES: To establish the prognostic value with sensitivity, specificity, positive predictive value, and negative predictive value for the OESIL syncope risk score to predict the presentation of severe outcomes (death, invasive interventions, and readmission) within 6 months of observation in adults who consult to the emergency department because of syncope. METHODS: Observational, prospective, and multicenter study with enrolment of subjects older than 18 years, who consulted to the emergency department because of syncope...
July 14, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28715609/new-graduate-nurses-professional-commitment-antecedents-and-outcomes
#12
Sylvie Guerrero, Denis Chênevert, Steven Kilroy
PURPOSE: This study examines the factors that increase new graduate nurses' professional commitment and how this professional commitment in turn affects professional turnover intentions, anxiety, and physical health symptoms. DESIGN: The study was carried out in association with the nursing undergraduate's affiliation of Quebec, Canada. A three-wave longitudinal design was employed among nursing students. Nurses were surveyed before they entered the labor market, and then twice after they started working...
July 17, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28712355/using-digital-media-advertising-in-early-psychosis-intervention
#13
Michael L Birnbaum, Chantel Garrett, Amit Baumel, Maria Scovel, Asra F Rizvi, Whitney Muscat, John M Kane
OBJECTIVE: Identifying and engaging youth with early-stage psychotic disorders in order to facilitate timely treatment initiation remains a major public health challenge. Although advertisers routinely use the Internet to directly target consumers, limited efforts have focused on applying available technology to proactively encourage help-seeking in the mental health community. This study explores how one might take advantage of Google AdWords in order to reach prospective patients with early psychosis...
July 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28712132/impact-of-lipoprotein-apheresis-with-dextran-sulfate-adsorption-on-the-expression-of-genes-involved-in-cardiovascular-health-in-the-blood-of-patients-with-homozygous-familial-hypercholesterolemia
#14
Jean-Philippe Drouin-Chartier, André J Tremblay, Jean Bergeron, Nathalie Laflamme, Benoît Lamarche, Patrick Couture
Lipoprotein apheresis (LA) with dextran sulfate adsorption (DSA) is a reliable method to decrease LDL-cholesterol (C) concentrations in patients with homozygous familial hypercholesterolemia (HoFH). The objective of the present study was to investigate the impact of LA with DSA on the mRNA expression of genes associated with cardiovascular health in the whole blood of HoFH patients. Blood samples were collected before and after LA treatment with DSA in 9 HoFH patients. Microarray analyses were performed to measure the whole blood expression of >30 000 annotated genes pre- and post-LA...
July 16, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28711536/the-outcomes-of-primary-transsphenoidal-surgery-in-cushing-s-disease-experience-of-a-tertiary-center
#15
Fatma Ela Keskin, Hande Mefkure Ozkaya, Murat Bolayirli, Secil Erden, Pınar Kadioglu, Necmettin Tanriover, Nurperi Gazioglu
BACKGROUND: To report the initial and long-term remission rates and related factors, secondary treatments, and outcomes of a series of patients with Cushing's disease (CD). METHODS: One hundred forty-seven consecutive adult patients with CD who underwent primary trans-sphenoidal surgery between 1998 and 2014 were included in this study. Eighty-two were followed up in Cerrahpasa Medical Faculty Endocrinology and Metabolism outpatient clinic. The patients were requested to attend a long-term remission assessment; 55 could be contacted and data for the remaining 27 patients' last visit to the outpatient clinics were reviewed for early and late remission...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28708643/rare-complication-in-third-maxillary-molar-extraction-dislocation-in-infratemporal-fossa
#16
Andrea Battisti, Paolo Priore, Filippo Giovannetti, Giorgio Barbera, Francesco D'Alessandro, Valentino Valentini
AIM: Removal of impacted third maxillary molar is frequently carried out without difficulties and low rate of intraoperative complications. The rare and particularly challenger to manage it is the third molar dislocation into the infratemporal fossa (IF). In this clinical report, the authors present their solution to manage and resolve this particular complication. METHODS: A 28-year-old woman was referred to the emergency rescue unit of the authors' hospital by her dentistry, after the attempt to extract the left impacted maxillary third molar...
July 13, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28707137/surface-modification-of-esophageal-stent-materials-by-a-polyethylenimine-layer-aiming-at-anti-cancer-function
#17
Kun Zhang, Yuxin Bai, Xiaofeng Wang, Qian Li, Fangxia Guan, Jingan Li
Esophageal cancer is difficult to cure globally and possesses high mortality rate, and it is generally accepted that palliative care such as stent implantation is the main therapy method for esophageal cancer in later period. However, the restenosis caused by tumor cells and inflammatory cells seriously interferes the stent clinical application and limits its long-term services. To solve this problem, series of drug delivery stents were developed and proven rather effective in the early stage of implantation, but more serious restenosis occurred after the drug delivery was over, which endangered the patients' life...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28706084/rationale-and-protocol-for-the-after-diabetes-diagnosis-research-support-system-address-an-incident-and-high-risk-type-1-diabetes-uk-cohort-study
#18
Helen C Walkey, Akaal Kaur, Vassiliki Bravis, Ian F Godsland, Shivani Misra, Alistair J K Williams, Polly J Bingley, David B Dunger, Nick Oliver, Desmond G Johnston
INTRODUCTION: Type 1 diabetes is heterogeneous in its presentation and progression. Variations in clinical presentation between children and adults, and with ethnic group warrant further study in the UK to improve understanding of this heterogeneity. Early interventions to limit beta cell damage in type 1 diabetes are undergoing evaluation, but recruitment is challenging. The protocol presented describes recruitment of people with clinician-assigned, new-onset type 1 diabetes to understand the variation in their manner of clinical presentation, to facilitate recruitment into intervention studies and to create an open-access resource of data and biological samples for future type 1 diabetes research...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28705637/-do-children-with-attention-deficit-and-hyperactivity-disorder-adhd-have-a-diferent-gait-pattern-relationship-between-idiopathic-toe-walking-and-adhd
#19
Víctor Soto Insuga, Beatriz Moreno Vinués, Rebeca Losada Del Pozo, María Rodrigo Moreno, Marta Martínez González, Raquel Cutillas Ruiz, Carmen Mateos Carmen
INTRODUCTION: Idiopathic toe-walking (ITW) is described as a gait pattern with no contact between the heels and the ground in children older than 3years. The diagnosis is clinical, making it necessary to rule out other neurological and orthopaedic conditions. A relationship between ITW and vestibular dysfunction and/or proprioceptive sensibility has been proposed. Children with neurodevelopmental disorders (autism, language and cognitive disorders) often have ITW. OBJECTIVES: To determine the frequency of ITW in children with attention deficit disorder and hyperactivity (ADHD)...
July 10, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28705204/delay-along-the-care-seeking-journey-of-patients-with-ocular-surface-squamous-neoplasia-in-kenya
#20
Stephen Gichuhi, Joy Kabiru, Alain M'bongo Zindamoyen, Hillary Rono, Ernest Ollando, Joseph Wachira, Rhoda Munene, Timothy Onyuma, Mandeep S Sagoo, David Macleod, Helen A Weiss, Matthew J Burton
BACKGROUND: In Africa, accessing eye health services is a major challenge. Ocular surface squamous neoplasia (OSSN) is a substantial ocular health problem in Africa related to solar UV light exposure and HIV infection among other risk factors. The disease causes visual loss and even death in advanced cases. This study was conducted to assess referral pathway and treatment delay for patients with OSSN in Kenya. METHODS: Adults with conjunctival lesions presenting to four eye centres were asked about their occupations, when they noticed the growth, health facilities visited in seeking care, cost of consultation, surgery, medicines and histopathology and dates at each step...
July 14, 2017: BMC Health Services Research
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