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https://www.readbyqxmd.com/read/28437260/early-postoperative-neuropathic-pain-assessed-by-the-dn4-score-predicts-an-increased-risk-of-persistent-postsurgical-neuropathic-pain
#1
Helene Beloeil, Barthelemy Sion, Chloe Rousseau, Pierre Albaladejo, Mathieu Raux, Frederic Aubrun, Valeria Martinez
BACKGROUND: Acute neuropathic pain can occur in the postoperative period but any link with persistent post-surgical neuropathic pain remains unclear. OBJECTIVES: The objectives of this study were to prospectively describe the incidence of acute post-surgical neuropathic pain in a large population using the DN4 (clinician administered) questionnaire and to confirm the hypothetical link between acute and persistent neuropathic pain at 2 months after surgery in a large population using the DN2 (self administered) questionnaire...
April 21, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28432419/-driving-and-dementia-an-issue-for-general-practice
#2
REVIEW
Verena Leve, Katharina Ilse, Marie Ufert, Stefan Wilm, Michael Pentzek
BACKGROUND: With most forms of dementia, the risk of road traffic accidents increases with disease progression. Addressing the issue of fitness to drive at an early stage can help to reduce driving-related risks and simultaneously preserve mobility. General practitioners (GPs) are central contact persons for dementia patients and their relatives in medical and psychosocial matters, and also play a key role in addressing the issue of driving safety. OBJECTIVE: Identification of relevant aspects of managing fitness to drive in dementia, as well as of support requirements for German general practice...
April 21, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28427367/determinants-of-delayed-care-seeking-for-tb-suggestive-symptoms-in-seru-district-oromiya-region-ethiopia-a-community-based-unmatched-case-control-study
#3
Robel Yirgu, Firaol Lemessa, Selamawit Hirpa, Abraham Alemayehu, Eveline Klinkenberg
BACKGROUND: Early tuberculosis (TB) case finding and adequate chemotherapy are essential for interrupting disease transmission and preventing complications due to delayed care seeking. This study was undertaken in order to provide insights into the magnitude and determinants of patient delay. METHODS: The study was conducted in rural Seru district, employing a population based unmatched case-control study design. The WHO standardized TB screening tool was used to identify presumptive TB cases among the district population ages > 15 years...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28426715/acute-hypoxia-influences-collagen-and-matrix-metalloproteinase-expression-by-human-keratoconus-cells-in-vitro
#4
Tina B McKay, Jesper Hjortdal, Shrestha Priyadarsini, Dimitrios Karamichos
Keratoconus (KC) is a progressive corneal ectasia linked to thinning of the central cornea. Hard contact lenses, rigid gas permeable lenses, and scleral lenses are the primary treatment modalities for early to mid- stages of KC to correct refractive error and astigmatism that develops as a result of an irregular corneal structure. These treatments are associated with significant drawbacks, including reduced availability of the tear film and oxygen to the corneal epithelium and stroma. However, it remains unknown whether hypoxia affects corneal integrity in the KC pathobiology...
2017: PloS One
https://www.readbyqxmd.com/read/28422368/safety-and-efficacy-of-pulmonary-vein-isolation-using-a-surround-flow-catheter-with-contact-force-measurement-capabilities-a-multicenter-registry
#5
Giuseppe Stabile, Paolo Di Donna, Vincenzo Schillaci, Antonio Di Monaco, Assunta Iuliano, Domenico Caponi, Francesco Urraro, Francesco Solimene, Massimo Grimaldi, Marco Scaglione
INTRODUCTION: Pulmonary vein (PV) isolation is the cornerstone of catheter ablation in patients with atrial fibrillation (AF). Surround flow and contact force (CF) measurement capabilities might enhance procedure efficacy and safety. We report on the safety and mid-term efficacy of a novel ablation catheter for PV isolation in patients with AF. METHODS AND RESULTS: Two hundred thirty-three consecutive patients (57±11 years, 76% males, 51% with structural heart disease) referred for paroxysmal (157) or persistent (76) AF, underwent PV isolation by a surround flow catheter with CF measurement capability in 4 centers...
April 19, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28414762/transcriptional-networks-are-associated-with-resistance-to-mycobacterium-tuberculosis-infection
#6
Chetan Seshadri, Nafiseh Sedaghat, Monica Campo, Glenna Peterson, Richard D Wells, Gregory S Olson, David R Sherman, Catherine M Stein, Harriet Mayanja-Kizza, Ali Shojaie, W Henry Boom, Thomas R Hawn
RATIONALE: Understanding mechanisms of resistance to M. tuberculosis (M.tb) infection in humans could identify novel therapeutic strategies as it has for other infectious diseases, such as HIV. OBJECTIVES: To compare the early transcriptional response of M.tb-infected monocytes between Ugandan household contacts of tuberculosis patients who demonstrate clinical resistance to M.tb infection (cases) and matched controls with latent tuberculosis infection. METHODS: Cases (n = 10) and controls (n = 18) were selected from a long-term household contact study in which cases did not convert their tuberculin skin test (TST) or develop tuberculosis over two years of follow up...
2017: PloS One
https://www.readbyqxmd.com/read/28414681/what-can-erode-through-lungs-bone-and-skin
#7
J M Manalac, D Shankaranayanan, J Paul-Olivier, L Guidry, N R Sells
CASE: A 51 year old African American Man without significant past history presented with three weeks of persistent cough productive of copious yellow sputum. He denied fevers, chills, hemoptysis, dyspnea, weight or appetite changes, sick contacts, recent travel. On physical examination, the patient was afebrile and appeared comfortable. He had decreased air entry of the left lower lobe with dullness to percussion. A 5x3 cm fluctuant mass was incidentally found on the left anterior chest wall at the level of the 11th rib with yellow expressible exudate at which time the patient reported a minor trauma sustained 3 weeks prior...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28411078/performance-of-the-xpert-%C3%A2-carba-r-v2-in-the-daily-workflow-of-a-hygiene-unit-in-a-country-with-a-low-prevalence-of-carbapenemase-producing-enterobacteriaceae
#8
Yannick Hoyos, Souad Ouzani, Laurent Dortet, Nicolas Fortineau, Thierry Naas
Early detection of patients colonised with carbapenemase-producing Enterobacteriaceae (CPE) is crucial for implementing proper infection control measures. Here we evaluated the biological performance of the Xpert(®) Carba-R v2 (Cepheid) in the daily workflow of a hygiene unit in a country with a low CPE prevalence. Patients repatriated from countries known for high CPE prevalence or contact patients of a known CPE carrier were targeted as being 'high-risk patients' for CPE carriage. Between September 2015 and March 2016, 241 'high-risk patients' for CPE carriage were screened using the Xpert(®) Carba-R v2 and by plating on chromID(®) CARBA Smart medium (bioMérieux) with and without ertapenem-containing enrichment culture for 24 h...
April 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28409008/two-year-outcome-after-early-or-late-intervention-in-non-st-elevation-acute-coronary-syndrome
#9
Erik A Badings, Wouter S Remkes, Salem H K The, Jan-Henk E Dambrink, Geert Tjeerdsma, Saman Rasoul, Jorik R Timmer, Marloes L J van der Wielen, Dirk J A Lok, Renicus S Hermanides, Jan Van Wijngaarden, Harry Suryapranata, Arnoud W J van 't Hof
OBJECTIVE: To compare long-term outcome of an early to a delayed invasive strategy in high-risk patients with non-ST elevation acute coronary syndrome (NSTE-ACS). METHODS: This prospective, multicentre trial included patients with NSTE-ACS and at least two out of three of the following high-risk criteria: (1) evidence of extensive myocardial ischaemia on ECG, (2) elevated biomarkers for myocardial necrosis and (3) age above 65 years. Patients were randomised to either an early (angiography and revascularisation if appropriate <12 hours) or a delayed invasive strategy (>48 hours after randomisation)...
2017: Open Heart
https://www.readbyqxmd.com/read/28407505/a-randomized-controlled-trial-on-providing-ankle-foot-orthoses-in-patients-with-sub-acute-stroke-short-term-kinematic-and-spatiotemporal-effects-and-effects-of-timing
#10
Corien D M Nikamp, Marte S H Hobbelink, Job van der Palen, Hermie J Hermens, Johan S Rietman, Jaap H Buurke
Initial walking function is often limited after stroke, and regaining walking ability is an important goal in rehabilitation. Various compensatory movement strategies to ensure sufficient foot-clearance are reported. Ankle-foot orthoses (AFOs) are often prescribed to improve foot-clearance and may influence these strategies. However, research studying effects of actual AFO-provision early after stroke is limited. We conducted an explorative randomized controlled trial and aimed to study the short-term effects of AFO-provision on kinematic and spatiotemporal parameters in patients early after stroke...
March 30, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28403225/association-of-vitamin-d-deficiency-season-of-the-year-and-latent-tuberculosis-infection-among-household-contacts
#11
María Elvira Balcells, Patricia García, Camila Tiznado, Luis Villarroel, Natalia Scioscia, Camila Carvajal, Francesca Zegna-Ratá, Mariluz Hernández, Paulina Meza, Luis F González, Carlos Peña, Rodrigo Naves
OBJECTIVES: Vitamin D (VD) enhances the immune response against Mycobacterium tuberculosis in vitro, and VD deficiency has been described in patients with active tuberculosis (TB). However, the role of hypovitaminosis D in the pathogenesis of early TB infection acquisition is unclear. We aimed to evaluate the association of VD deficiency, season of the year, and latent TB infection in household contacts (HHC), given that this is a potentially modifiable condition often related to nutritional deficiencies and lack of sun exposure...
2017: PloS One
https://www.readbyqxmd.com/read/28401141/knowledge-attitude-willingness-and-readiness-of-primary-health-care-providers-to-provide-oral-health-services-to-children-in-niagara-ontario-a-cross-sectional-survey
#12
Sonica Singhal, Rafael Figueiredo, Sandy Dupuis, Rachel Skellet, Tara Wincott, Carolyn Dyer, Andrea Feller, Carlos Quiñonez
BACKGROUND: Most children are exposed to medical, but not dental, care at an early age, making primary health care providers an important player in the reduction of tooth decay. The goal of this research was to understand the feasibility of using primary health care providers in promoting oral health by assessing their knowledge, attitude, willingness and readiness in this regard. METHODS: Using the Dillman method, a mail-in cross-sectional survey was conducted among all family physicians and pediatricians in the Niagara region of Ontario who have primary contact with children...
January 2017: CMAJ Open
https://www.readbyqxmd.com/read/28400041/heart-attack-guidance-for-physicians-when-to-suspect-how-to-diagnose-what-to-do
#13
EDITORIAL
K K Aggarwal, Sundeep Mishra
Lack of awareness among the first contact physicians is one of the major causes for delay in reperfusion therapy in India. Physicians need not only clear-cut guidance about when to perform an ECG and when to refer a patient but also need to understand the mortality advantage of early intervention as well as medico-legal aspects of this condition.
April 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28395674/antipsychotic-treatment-resistance-in-first-episode-psychosis-prevalence-subtypes-and-predictors
#14
A Demjaha, J M Lappin, D Stahl, M X Patel, J H MacCabe, O D Howes, M Heslin, U A Reininghaus, K Donoghue, B Lomas, M Charalambides, A Onyejiaka, P Fearon, P Jones, G Doody, C Morgan, P Dazzan, R M Murray
BACKGROUND: We examined longitudinally the course and predictors of treatment resistance in a large cohort of first-episode psychosis (FEP) patients from initiation of antipsychotic treatment. We hypothesized that antipsychotic treatment resistance is: (a) present at illness onset; and (b) differentially associated with clinical and demographic factors. METHOD: The study sample comprised 323 FEP patients who were studied at first contact and at 10-year follow-up...
April 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28390069/antimicrobial-agents-for-preventing-peritonitis-in-peritoneal-dialysis-patients
#15
REVIEW
Denise Campbell, David W Mudge, Jonathan C Craig, David W Johnson, Allison Tong, Giovanni Fm Strippoli
BACKGROUND: Peritoneal dialysis (PD) is an important therapy for patients with end-stage kidney disease and is used in more than 200,000 such patients globally. However, its value is often limited by the development of infections such as peritonitis and exit-site and tunnel infections. Multiple strategies have been developed to reduce the risk of peritonitis including antibiotics, topical disinfectants to the exit site and antifungal agents. However, the effectiveness of these strategies has been variable and are based on a small number of randomised controlled trials (RCTs)...
April 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28389225/prognosis-of-asymptomatic-and-symptomatic-undiagnosed-copd-in-the-general-population-in-denmark-a-prospective-cohort-study
#16
Yunus Çolak, Shoaib Afzal, Børge G Nordestgaard, Jørgen Vestbo, Peter Lange
BACKGROUND: COPD can be diagnosed early using spirometry, but spirometry use is only recommended in symptomatic smokers, even though early stages of COPD can be asymptomatic. We investigated the prognosis of individuals with asymptomatic and symptomatic, undiagnosed COPD in the general population in Denmark. METHODS: In this prospective cohort study, we analysed data from 95 288 individuals aged 20-100 years from the Copenhagen General Population Study. 32 518 (34%) of these individuals were regarded as being at high risk for COPD (defined as individuals aged 40 years or older, with cumulative tobacco consumption of ten pack-years or higher, and without self-reported or a previous hospital contact for asthma)...
April 4, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28386925/vagus-nerve-stimulation-surgical-technique-of-implantation-and-revision-and-related-morbidity
#17
Flavio Giordano, Anna Zicca, Carmen Barba, Renzo Guerrini, Lorenzo Genitori
Indications for vagus nerve stimulation (VNS) therapy include focal, multifocal epilepsy, drop attacks (tonic/atonic seizures), Lennox-Gastaut syndrome, tuberous sclerosis complex (TSC)-related multifocal epilepsy, and unsuccessful resective surgery. Surgical outcome is about 50-60% for seizures control, and may also improve mood, cognition, and memory. On this basis, VNS has also been proposed for the treatment of major depression and Alzheimer's' disease. The vagus nerve stimulator must be implanted with blunt technique on the left side to avoid cardiac side effects through the classic approach for anterior cervical discectomy...
April 2017: Epilepsia
https://www.readbyqxmd.com/read/28384214/care-of-cancer-patients-at-the-end-of-life-in-a-german-university-hospital-a-retrospective-observational-study-from-2014
#18
Burkhard Dasch, Helen Kalies, Berend Feddersen, Caecilie Ruderer, Wolfgang Hiddemann, Claudia Bausewein
BACKGROUND: Cancer care including aggressive treatment procedures during the last phase of life in patients with incurable cancer has increasingly come under scrutiny, while integrating specialist palliative care at an early stage is regarded as indication for high quality end-of-life patient care. AIM: To describe the demographic and clinical characteristics and the medical care provided at the end of life of cancer patients who died in a German university hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28384084/strengthening-integrated-care-through-population-focused-primary-care-services-international-experiences-outside-the-united-states
#19
Rene Loewenson, Sarah Simpson
Many high- and middle-income countries (HMICs) are experiencing a burden of comorbidity and chronic diseases. Together with increasing patient expectations, this burden is raising demand for population health-oriented innovation in health care. Using desk review and country case studies, we examine strategies applied in HMICs outside the United States to address these challenges, with a focus on and use of a new framework for analyzing primary care (PC). The article outlines how a population health approach has been supported by focusing assessment on and clustering services around social groups and multimorbidity, with support for community roles...
March 20, 2017: Annual Review of Public Health
https://www.readbyqxmd.com/read/28379967/isolation-of-dengue-virus-from-the-upper-respiratory-tract-of-four-patients-with-dengue-fever
#20
Nai-Ming Cheng, Cheng Len Sy, Bao-Chen Chen, Tsi-Shu Huang, Susan Shin-Jung Lee, Yao-Shen Chen
BACKGROUND: Dengue fever is an important arboviral disease. The clinical manifestations vary from a mild non-specific febrile syndrome to severe life-threatening illness. The virus can usually be detected in the blood during the early stages of the disease. Dengue virus has also been found in isolated cases in the cerebrospinal fluid, urine, nasopharyngeal sections and saliva. In this report, we describe the isolation of dengue virus from the upper respiratory tract of four confirmed cases of dengue...
April 2017: PLoS Neglected Tropical Diseases
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