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Dilated Aorta

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https://www.readbyqxmd.com/read/28903936/aortic-valve-stenosis-alters-expression-of-regional-aortic-wall-shear-stress-new-insights-from-a-4-dimensional-flow-magnetic-resonance-imaging-study-of-571-subjects
#1
Pim van Ooij, Michael Markl, Jeremy D Collins, James C Carr, Cynthia Rigsby, Robert O Bonow, S Chris Malaisrie, Patrick M McCarthy, Paul W M Fedak, Alex J Barker
BACKGROUND: Wall shear stress (WSS) is a stimulus for vessel wall remodeling. Differences in ascending aorta (AAo) hemodynamics have been reported between bicuspid aortic valve (BAV) and tricuspid aortic valve patients with aortic dilatation, but the confounding impact of aortic valve stenosis (AS) is unknown. METHODS AND RESULTS: Five hundred seventy-one subjects underwent 4-dimensional flow magnetic resonance imaging in the thoracic aorta (210 right-left BAV cusp fusions, 60 right-noncoronary BAV cusp fusions, 245 tricuspid aortic valve patients with aortic dilatation, and 56 healthy controls)...
September 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28902822/assessing-the-effect-of-endoprosthetic-repair-of-the-thoracic-portion-on-aortic-remodelling-after-surgical-correction-for-debakey-type-i-dissection
#2
V V Bazylev, M G Shmatkov, D A Zakharov, Z A Morozov
OBJECTIVE: The purpose of the study was to evaluate the influence of endoprosthetic repair of the aortic thoracic portion on remodelling of the descending aorta in patients after the surgical stage of correction for DeBakey type I aortic dissection. PATIENTS AND METHODS: The authors retrospectively analysed a group of 12 patients (9 men and 3 women) subjected to endoprosthetic repair of the aortic thoracic portion after previously performed surgical correction of the ascending aorta and its braches...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28894052/-three-surgical-cases-of-quadricuspid-aortic-valve
#3
Yoshikazu Motohashi, Takahiro Katsumata, Tatsuya Suzuki, Ryo Shimada, Hayato Konishi, Shinji Fukuhara, Sachiko Kanki, Masahiro Daimon, Hideki Ozawa, Shintaro Nemoto
Quadricuspid aortic valve is a rare congenital disease. We experienced 3 surgical cases of quadricuspid aortic valve. Patient 1 was a 72-year-old man who was noted to have a quadricuspid aortic valve associated with aortic regurgitation and an ascending aortic aneurysm(51 mm in diameter). He underwent replacement of the aortic valve and the ascending aorta. Patient 2 was a 71-year-old man with severe aortic stenosis, regurgitation, and coronary triple vessel disease. He underwent aortic valve replacement and coronary artery bypass grafting...
September 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28893830/assessment-of-paravalvular-leakage-after-transcatheter-aortic-valve-implantation-add-clinical-signs-to-echocardiographic-data
#4
Corstiaan A den Uil, Mihai Strachinaru, Ben van der Hoven, J Han J Meeder
A 62-year old male with pulmonary fibrosis and aortic valve stenosis underwent TAVI (Corevalve Evolut XL 34 mm) in the build-up for lung transplantation (LuTx). Following post-dilation for a large annular perimeter, moderate paravalvular aortic regurgitation (AR) was observed. After 6 weeks, he was admitted to the ICU with respiratory failure(A). TTE demonstrated residual mild AR (based on a small excentric paravalvular AR jet, <10% circumferential extent, pressure half-time was not reliably measured) and together with borderline elevated NT-pro-BNP, the consultant cardiologist authorized LuTx listing...
September 11, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28890987/impact-of-patient-specific-inflow-velocity-profile-on-hemodynamics-of-the-thoracic-aorta
#5
Pouya Youssefi, Alberto Gomez, Christopher Arthurs, Rajan Sharma, Marjan Jahangiri, Alberto Figueroa
Background-Computational fluid dynamics (CFD) provides a non-invasive method to functionally assess aortic hemodynamics. The thoracic aorta has an anatomically complex inlet comprising of the aortic valve, which is highly prone to different morphologies and pathologies. We investigated the effect of using patient-specific inflow velocity profiles compared to idealised profiles based on the patient's flow waveform. Methods-A healthy 31yo with a normally functioning tricuspid aortic valve (subject A), and a 52yo with a bicuspid aortic valve, aortic valvular stenosis and dilated ascending aorta (subject B) were studied...
September 11, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28890470/circulating-angptl2-levels-increase-in-humans-and-mice-exhibiting-cardiac-dysfunction
#6
Zhe Tian, Keishi Miyata, Jun Morinaga, Haruki Horiguchi, Tsuyoshi Kadomatsu, Motoyoshi Endo, Jiabin Zhao, Shunshun Zhu, Taichi Sugizaki, Michio Sato, Kazutoyo Terada, Takahiro Okumura, Toyoaki Murohara, Yuichi Oike
BACKGROUND: Recently, it was reported that angiopoietin-like protein 2 (ANGPTL2) secreted from a pathologically stressed heart accelerates cardiac dysfunction in an autocrine/paracrine manner, and that suppression of ANGPTL2 production in the heart restored cardiac function and myocardial energy metabolism, thereby blocking heart failure (HF) development. Interestingly, circulating ANGPTL2 concentrations reportedly increase in HF patients, suggesting a possible endocrine effect on cardiac dysfunction...
September 8, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28887562/metformin-improves-endothelial-function-and-reduces-blood-pressure-in-diabetic-spontaneously-hypertensive-rats-independent-from-glycemia-control-comparison-to-vildagliptin
#7
Mahdi Hamidi Shishavan, Robert H Henning, Azuwerus van Buiten, Maaike Goris, Leo E Deelman, Hendrik Buikema
Metformin confers vascular benefits beyond glycemia control, possibly via pleiotropic effects on endothelial function. In type-1-diabetes-mellitus (T1DM-)patients metformin improved flow-mediated dilation but also increased prostaglandin(PG)-F2α, a known endothelial-contracting factor. To explain this paradoxical finding we hypothesized that metformin increased endothelial-vasodilator mediators (e.g. NO and EDHF) to an even larger extent. Spontaneously-hypertensive-rats (SHR) display impaired endothelium-dependent relaxation (EDR) involving contractile PGs...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886508/effects-of-clinico-pathological-risk-factors-on-in-vitro-mechanical-properties-of-human-dilated-ascending-aorta
#8
Anna Ferrara, Pasquale Totaro, Simone Morganti, Ferdinando Auricchio
Ascending aorta aneurysms (AsAA) are associated with a degeneration of the aortic wall tissue, which leads to changes in tissue mechanical properties. Risk factors for the development of the AsAA disease are recognized in patient age and gender, valve type, hypertension, diabetes mellitus, smoking history, and a prior diagnosis of Marfan syndrome. The present study aims to assess how such clinico-pathological factors can affect the mechanical properties of human dilated ascending aorta. Specimens of AsAA are excised from 68 patients who underwent elective AsAA surgical repair and stretched until rupture during the execution of uniaxial tensile tests...
August 31, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28884233/in-vivo-strain-analysis-of-dilated-ascending-thoracic-aorta-by-ecg-gated-ct-angiographic-imaging
#9
Salvatore Pasta, Valentina Agnese, Marzio Di Giuseppe, Giovanni Gentile, Giuseppe M Raffa, Diego Bellavia, Michele Pilato
Accurate assessment of aortic extensibility is a requisite first step for elucidating the pathophysiology of an ascending thoracic aortic aneurysm (ATAA). This study aimed to develop a framework for the in vivo evaluation of the full-field distribution of the aortic wall strain by imaging analysis of electrocardiographic- (ECG) gated thoracic data of 34 patients with ATAA. Seven healthy controls (i.e., non-aneurysmal aorta) from patients who underwent ECG-gated CT angiography for coronary artery diseases were included for comparison...
September 7, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28874282/smad4-gene-mutation-increases-the-risk-of-aortic-dilation-in-patients-with-hereditary-haemorrhagic-telangiectasia
#10
V M M Vorselaars, A Diederik, V Prabhudesai, S Velthuis, J-A Vos, R J Snijder, C J J Westermann, B J Mulder, J K Ploos van Amstel, J J Mager, M E Faughnan, M C Post
BACKGROUND: Mutations in the genes ENG, ACVRL1 and SMAD4 that are part of the transforming growth factor-beta signalling pathway cause hereditary haemorrhagic telangiectasia (HHT). Mutations in non-HHT genes within this same pathway have been found to associate with aortic dilation. Therefore, we investigated the presence of aortic dilation in a large cohort of HHT patients as compared to non-HHT controls. METHODS: Chest computed tomography of consecutive HHT patients (ENG, ACVRL1 and SMAD4 mutation carriers) and non-HHT controls were reviewed...
October 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28870223/modified-candy-plug-technique-for-chronic-type-b-aortic-dissection-with-aneurysmal-dilatation-a-case-report
#11
Sohsyu Kotani, Yoshito Inoue, Mio Kasai, Satoru Suzuki, Takashi Hachiya
BACKGROUND: The original 'candy-plug' technique has been reported to be beneficial for the treatment of residual perfused false lumen in patients with aortic dissection. However, this technique is also associated with several problems, such as narrowing of the true lumen and damage to the flap or vessel wall. Therefore, we modified the procedure to overcome these problems. Here we report a case in which the patient was successfully treated using the modified procedure. CASE PRESENTATION: A 59-year-old man presented with chronic type B aortic dissection with aneurysmal dilatation...
September 5, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28868315/impact-of-thoracic-endovascular-repair-on-pulsatile-aortic-strain-in-acute-type-b-aortic-dissection-preliminary-results
#12
Foeke J H Nauta, Guido H W van Bogerijen, Michele Conti, Chiara Trentin, Frans L Moll, Joost A Van Herwaarden, Ferdinando Auricchio, Santi Trimarchi
BACKGROUND: The impact of thoracic endovascular aortic repair (TEVAR) on pulsatile aortic strain remains undetermined in patients with Type B aortic dissection (TBAD). Therefore, we quantified pulsatile aortic strain in TBAD patients and control subjects. METHODS: We retrospectively analyzed two TBAD patients from our database with cardiac-gated computed tomography angiography imaging available before and after TEVAR and two control subjects (67- and 76-year-old males)...
April 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28865366/buyanghuanwu-decoction-alleviated-pressure-overload-induced-cardiac-remodeling-by-suppressing-tgf-%C3%AE-smads-and-mapks-signaling-activated-fibrosis
#13
Huihua Chen, Haiyan Song, Xiao Liu, Jing Tian, Wenzhu Tang, Tongtong Cao, Pei Zhao, Chen Zhang, Wei Guo, Ming Xu, Rong Lu
Buyanghuanwu Decoction (BHD), a traditional Chinese medicine recipe, is a representative prescription for the treatment of qi-deficiency and blood-stasis syndrome. In this study, the effect of BHD on pressure overload induced cardiac remodeling was investigated and possible mechanism underlying was explored. Rats were randomly divided into four groups: sham, transverse aorta constriction (TAC) with saline, TAC with telmisartan (TAC+Tel), and TAC with BHD (TAC+BHD) for 16 weeks (n=6∼8 in each group). Cardiac morphological and functional changes were evaluated by echocardiography and histological methods, the molecular alterations were detected by western blotting...
August 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28864719/anatomical-and-clinical-predictors-of-valve-dysfunction-and-aortic-dilation-in-bicuspid-aortic-valve-disease
#14
Arturo Evangelista, Pastora Gallego, Francisco Calvo-Iglesias, Javier Bermejo, Juan Robledo-Carmona, Violeta Sánchez, Daniel Saura, Roman Arnold, Amelia Carro, Giuliana Maldonado, Augusto Sao-Avilés, Gisela Teixidó, Laura Galian, José Rodríguez-Palomares, David García-Dorado
OBJECTIVE: Bicuspid aortic valve (BAV) is associated with early valvular dysfunction and proximal aorta dilation with high heterogeneity. This study aimed to assess the determinants of these complications. METHODS: Eight hundred and fifty-two consecutive adults diagnosed of BAV referred from cardiac outpatient clinics to eight echocardiographic laboratories of tertiary hospitals were prospectively recruited. Exclusion criteria were aortic coarctation, other congenital disorders or intervention...
September 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28861437/saccular-kommerell-aneurysm-a-potential-pitfall-on-mdct-imaging-a-review-of-imaging-features-and-potential-mimics
#15
REVIEW
Hui Lin Wong, Charlene Jin Yee Liew, Angeline Choo Choo Poh
Saccular Kommerell aneurysm represents a potential pitfall on Multidetector CT (MDCT) imaging, mimicking conditions such as saccular aneurysm of the thoracic aorta, ductus diverticulum and dilated Kommerell diverticulum. Accurate diagnosis of this condition is critical in the management of this potentially fatal condition. This paper reviews the MDCT imaging features of Kommerell aneurysms and its mimics and demonstrates how to make an accurate diagnosis through a series of four cases. MDCT features of Kommerell aneurysms, either saccular or fusiform types arising from a Kommerell diverticulum with atherosclerotic plaque and mural thrombus are discussed...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28858090/prenatal-ultrasonic-diagnosis-of-absent-pulmonary-valve-syndrome-a-case-report
#16
Wen-Jun Zhang, Zhong-Lei Zhang, Jun-Jie Chang, Xiao-Yu Song
RATIONALE: Absent pulmonary valve syndrome (APVS) is a rare congenital heart disease that is often associated with tetralogy of Fallot (TOF). Here, we report 2 cases of APVS associated with TOF diagnosed via fetal echocardiography and discuss their specific ultrasonographic characteristics. PATIENT CONCERNS: Two pregnant women with suspicion of fetal heart anomaly were referred from their local hospitals to our hospital for fetal malformation screening and detailed fetal echocardiography...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28843154/numerical-analysis-of-wall-shear-stress-in-ascending-aorta-before-tearing-in-type-a-aortic-dissection
#17
Qingzhuo Chi, Ying He, Yong Luan, Kairong Qin, Lizhong Mu
Although the incidence of many cardiovascular diseases has declined as medical treatments have improved, the prevalence of aortic dissection (AD) has increased. Compared to type B dissections, type A dissections are more severe, and most patients with type A dissections require surgical treatment. The objective of this study was to investigate the relationships between the wall shear stress (WSS) on the aortic endothelium and the frequent tearing positions using computational fluid dynamics. Five type A dissection cases and two normal aortas were included in the study...
August 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28839206/grape-seed-polyphenols-play-a-protective-role-in-elastase-induced-abdominal-aortic-aneurysm-in-mice
#18
Chao Wang, Yunxia Wang, Maomao Yu, Cong Chen, Lu Xu, Yini Cao, Rong Qi
Abdominal aortic aneurysm (AAA) is a kind of disease characterized by aortic dilation, whose pathogenesis is linked to inflammation. This study aimed to determine whether grape-seed polyphenols (GSP) has anti-AAA effects and what mechanism is involved, thus to find a way to prevent occurrence and inhibit expansion of small AAA. In our study, AAA was induced by incubating the abdominal aorta of the mice with elastase, and GSP was administrated to the mice by gavage at different doses beginning on the day of the AAA inducement...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833432/elasticity-of-ascending-aorta-and-left-ventricular-myocardial-functions-in-children-with-bicuspid-aortic-valve
#19
Filiz Ekici, Diyar Uslu, Selen Bozkurt
BACKGROUND: The aim of the study was to determine the aortic elasticity parameters (EPs) and myocardial function in children with bicuspid aortic valve (BAV). Additionally, we evaluated the effect of aortic leaflet phenotype (ALP) and aortic dilatation on elasticity parameters. METHODS: Sixty-two children diagnosed with isolated BAV (mean age 9.3 years old; patient group) and 63 healthy children (control group) have been evaluated for this study. Patient group was divided into three age subgroups: between 0-6, 7-11 and 12-17 age intervals...
August 22, 2017: Echocardiography
https://www.readbyqxmd.com/read/28830708/analysis-of-origin-of-the-supra-aortic-trunks-from-the-aortic-arch
#20
Daniela Mazzaccaro, Massimiliano Sciarrini, Giovanni Nano
OBJECTIVE: The objective of this study was to describe in the general population the anatomy of the supra-aortic trunks (SATs: brachiocephalic trunk [BCT], left common carotid artery [LCCA], and left subclavian artery [LSA]) arising from the aortic arch in terms of mutual distances from the valvular aortic plane (VAP), ostial diameters, and clock face orientation from the sagittal aortic axis, with an analysis of each distribution. METHODS: Measurements of 252 computed tomography angiograms of the aortic arch and SATs in three groups of patients (84 without any disease of the aortic arch, group A; 84 with dilation of the aortic arch, group B; 84 with dilation of the descending thoracic aorta below the LSA, group C) were retrospectively collected and analyzed...
August 19, 2017: Journal of Vascular Surgery
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