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https://www.readbyqxmd.com/read/28795793/an-unprecedented-case-a-low-specific-surface-area-anatase-n-doped-carbon-nanocomposite-derived-from-a-new-single-source-precursor-affords-fast-and-stable-lithium-storage
#1
Man Gao, Kaixiang Zou, Yuanfu Deng, Zhenxia Zhao, Yingwei Li, Guohua Chen
A nanocomposite of ultra-fine anatase nanoparticles (< 5 nm) embedded N-doped carbon (TiO2-NPs/NC) with a relatively low specific surface area was successfully synthesized by in-situ pyrolysis of a new and cheap single source precursor of (H2en)3[Ti4(O2)4(Hcit)2(cit)2]∙12H2O (en = ethylenediamine and H4cit = citric acid) under 550 oC and inert atmosphere. The precursor in crystalline state was isolated from an aqueous solution containing of titanium butoxide, citric acid, hydrogen peroxide and ethylenediamine and was characterized...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28773224/er-doped-lini0-5mn1-5o%C3%A2-cathode-material-with-enhanced-cycling-stability-for-lithium-ion-batteries
#2
Shanshan Liu, Hongyuan Zhao, Ming Tan, Youzuo Hu, Xiaohui Shu, Meiling Zhang, Bing Chen, Xingquan Liu
The Er-doped LiNi0.5Mn1.5O₄ (LiNi0.495Mn1.495Er0.01O₄) sample was successfully prepared by citric acid-assisted sol-gel method with erbium oxide as an erbium source for the first time. Compared with the undoped sample, the Er-doped LiNi0.5Mn1.5O₄ sample maintained the basic spinel structure, suggesting that the substitution of Er(3+) ions for partial nickel and manganese ions did not change the intrinsic structure of LiNi0.5Mn1.5O₄. Moreover, the Er-doped LiNi0.5Mn1.5O₄ sample showed better size distribution and regular octahedral morphology...
July 27, 2017: Materials
https://www.readbyqxmd.com/read/28765595/integration-of-mirna-and-mrna-expression-profiles-reveals-microrna-regulated-networks-during-muscle-wasting-in-cardiac-cachexia
#3
Leonardo N Moraes, Geysson J Fernandez, Ivan J Vechetti-Júnior, Paula P Freire, Rodrigo W A Souza, Rolando A R Villacis, Silvia R Rogatto, Patricia P Reis, Maeli Dal-Pai-Silva, Robson F Carvalho
Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms have been proposed to explain muscle wasting during CC, its pathogenesis is still not understood. Here, we described an integrative analysis between miRNA and mRNA expression profiles of muscle wasting during CC. Global gene expression profiling identified 1,281 genes and 19 miRNAs differentially expressed in muscle wasting during CC. Several of these deregulated genes are known or putative targets of the altered miRNAs, including miR-29a-3p, miR-29b-3p, miR-210-5p, miR-214, and miR-489...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28761941/effects-of-different-concentrations-and-excipients-of-titanium-tetrafluoride-on-dentin-erosion-prevention
#4
Taís Mantilla, Thayanne Ramos-Oliveira, Camila Silva, Maria Cersosimo, Cecilia Turssi, Patricia Freitas
PURPOSE: To evaluate the preventive effect of titanium fluoride (TiF4) gel and solution, in different concentrations, on dentin erosion. MATERIALS AND METHODS: Of 140 root dentin slabs (3 x 3 x 1 mm) cut from 70 freshly extracted human third molars, 70 with intermediate Knoop microhardness and lowest surface curvature were selected and randomly divided into 7 groups (n = 10): G1: negative control (no treatment); G2: positive control (AmF/NaF/SnCl2 solution); G3: placebo gel (no fluoride); G4: 1% TiF4 solution; G5: 1% TiF4 gel; G6: 4% TiF4 solution; G7: 4% TiF4 gel...
July 31, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28759166/altered-metabolites-of-the-rat-hippocampus-after-mild-and-moderate-traumatic-brain-injury-a-combined-in-vivo-and-in-vitro-1-h-mrs-study
#5
Kavita Singh, Richa Trivedi, Ajay Verma, Maria M D'souza, Sunil Koundal, Poonam Rana, Bikash Baishya, Subash Khushu
Traumatic brain injury (TBI) has been shown to affect hippocampus-associated learning, memory and higher cognitive functions, which may be a consequence of metabolic alterations. Hippocampus-associated disorders may vary depending on the severity of injury [mild TBI (miTBI) and moderate TBI (moTBI)] and time since injury. The underlying hippocampal metabolic irregularities may provide an insight into the pathological process following TBI. In this study, in vivo and in vitro proton magnetic resonance spectroscopy ((1) H-MRS) data were acquired from the hippocampus region of controls and TBI groups (miTBI and moTBI) at D0 (pre-injury), 4 h, Day 1 and Day 5 post-injury (PI)...
July 31, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28758940/non-targeted-metabolomics-analysis-of-golden-retriever-muscular-dystrophy-affected-muscles-reveals-alterations-in-arginine-and-proline-metabolism-and-elevations-in-glutamic-and-oleic-acid-in-vivo
#6
Muhammad Abdullah, Joe N Kornegay, Aubree Honcoop, Traci L Parry, Cynthia J Balog-Alvarez, Sara K O'Neal, James R Bain, Michael J Muehlbauer, Christopher B Newgard, Cam Patterson, Monte S Willis
BACKGROUND: Like Duchenne muscular dystrophy (DMD), the Golden Retriever Muscular Dystrophy (GRMD) dog model of DMD is characterized by muscle necrosis, progressive paralysis, and pseudohypertrophy in specific skeletal muscles. This severe GRMD phenotype includes moderate atrophy of the biceps femoris (BF) as compared to unaffected normal dogs, while the long digital extensor (LDE), which functions to flex the tibiotarsal joint and serves as a digital extensor, undergoes the most pronounced atrophy...
July 29, 2017: Metabolites
https://www.readbyqxmd.com/read/28758716/tif4-gel-effects-on-tubular-occlusion-of-eroded-abraded-human-dentin
#7
Taís Fonseca Mantilla, Camila Vieira da Silva, Thayanne Monteiro Ramos-Oliveira, Cecilia Pedroso Turssi, Martha Simões Ribeiro, Patricia Moreira de Freitas
This in situ study evaluated the tubular occlusion caused by 4% TiF4 gel on the surface of eroded/abraded dentin. Sixty human dentin samples were eroded in vitro and assigned into six groups (n = 10) according to the in situ surface treatment and number of cycling days: 4% TiF4 gel applied once (TiF4 1), twice (TiF4 2), or three times (TiF4 3) followed by 2, 4, and 6 days of erosive/abrasive in situ cycling, respectively. Control groups (no treatment) were subjected to 2 (C1), 4 (C2), and 6 (C3) days of erosive/abrasive in situ cycling only...
July 31, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28758404/lycopene-prevents-mitochondrial-dysfunction-during-d-galactosamine-lipopolysaccharide-induced-fulminant-hepatic-failure-in-albino-rats
#8
Sheik Abdulazeez Sheriff, Shaikhussain Shaik Ibrahim, Thiruvengadam Devaki, Sandipan Chakraborty, Subhash Agarwal, Horacio Perez-Sanchez
Fulminant hepatic failure (FHF) is a serious health issue, with a high mortality rate and characterized by severe perturbation in mitochondrial function. D-Galactosamine/lipopolysaccharide (D-GalN/LPS) induced FHF is a renowned model to evaluate the efficacy of hepatoprotective agents. Lycopene is an antioxidant and phytonutrient from carotenoid family. The health benefits of lycopene are prominent against cancer, cardiovascular, lung, liver, and skin problems. Recent studies have demonstrated the hepatoprotective, antidyslipidemic, and antioxidant roles of lycopene...
July 31, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28747703/linking-the-morphological-and-metabolomic-response-of-lactuca-sativa-l-exposed-to-emerging-contaminants-using-gc%C3%A2-%C3%A3-%C3%A2-gc-ms-and-chemometric-tools
#9
Carlos Hurtado, Hadi Parastar, Víctor Matamoros, Benjamín Piña, Romà Tauler, Josep M Bayona
The occurrence of contaminants of emerging concern (CECs) in irrigation waters (up to low μg L(-1)) and irrigated crops (ng g(-1) in dry weight) has been reported, but the linkage between plant morphological changes and plant metabolomic response has not yet been addressed. In this study, a non-targeted metabolomic analysis was performed on lettuce (Lactuca sativa L) exposed to 11 CECs (pharmaceuticals, personal care products, anticorrosive agents and surfactants) by irrigation. The plants were watered with different CEC concentrations (0-50 µg L(-1)) for 34 days under controlled conditions and then harvested, extracted, derivatised and analysed by comprehensive two-dimensional gas chromatography coupled to a time-of-flight mass spectrometer (GC × GC-TOFMS)...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747166/cascade-fumarate-hydratase-mutation-screening-allows-early-detection-of-kidney-tumour-a-case-report
#10
Melanie M Y Chan, Angela Barnicoat, Faiz Mumtaz, Michael Aitchison, Lucy Side, Helen Brittain, Alan W H Bates, Daniel P Gale
BACKGROUND: Fumarate hydratase (FH) deficiency is a rare autosomal recessive disorder which results in a major defect in cellular metabolism. It presents in infancy with progressive encephalopathy, hypotonia, seizures and failure to thrive and is often fatal in childhood. It is caused by mutations in the FH gene (1q42.1) that result in deficiency of the citric acid cycle enzyme fumarate hydratase, resulting in accumulation of fumaric acid. Heterozygous germline mutations in the FH gene predispose to an aggressive autosomal dominant inherited early-onset kidney cancer syndrome: hereditary leiomyomatosis and renal cell cancer (HLRCC)...
July 26, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28743573/loading-of-chitosan-nano-metal-oxide-hybrids-onto-cotton-polyester-fabrics-to-impart-permanent-and-effective-multifunctions
#11
Nabil A Ibrahim, Basma M Eid, Eman Abd El-Aziz, Tarek M Abou Elmaaty, Shaimaa M Ramadan
New and durable multifunctional properties of cotton/polyester blended fabrics were developed through loading of chitosan (Cs) and various metal oxide nanoparticles (MONPs) namely ZnO, TiO2, and SiO2 onto fabric surface using citric acid/Sodium hypophosphite for ester-crosslinking and creating new anchoring and binding sites, COOH groups, onto the ester-crosslinked fabrics surface. The surface morphology and the presence of active ingredients (Cs & MONPs) onto selected - coated fabric samples were analyzed by SEM images and confirmed by EDS spectrums...
July 22, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28741793/telomerase-enzyme-deficiency-promotes-metabolic-dysfunction-in-murine-hepatocytes-upon-dietary-stress
#12
Raquel M Alves-Paiva, Sachiko Kajigaya, Xingmin Feng, Jichun Chen, Marie Desierto, Susan Wong, Danielle M Townsley, Flávia S Donaires, Adeline Bertola, Bin Gao, Neal S Young, Rodrigo T Calado
Short telomeres and genetic telomerase defects are risk factors for some human liver diseases, ranging from non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) to cirrhosis. In murine models, telomere dysfunction has been shown to metabolically compromise hematopoietic cells, liver, and heart via the activation of the p53-PGC axis METHODS: Tert- and Terc-deficient mice were challenged with liquid high fat diet (HFD). Liver metabolic contents were analyzed by CE-TOFMS and liver fat content was confirmed by confocal and electronic microscopy RESULTS: Tert-deficient but not Terc-deficient mice develop hepatocyte injury and frank steatosis when challenged with liquid HFD...
July 25, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28722260/effect-of-long-distance-transportation-on-serum-metabolic-profiles-of-steer-calves
#13
Satoshi Takemoto, Shozo Tomonaga, Masayuki Funaba, Tohru Matsui
Long-distance transportation is sometimes inevitable in the beef industry because of the geographic separation of major breeding and fattening areas. Long-distance transportation negatively impacts production and health of cattle, which may, at least partly, result from the disturbance of metabolism during and after transportation. However, alteration of metabolism remains elusive in transported cattle. We investigated the effects of transportation on the metabolomic profiles of Holstein steer calves. Non-targeted analysis of serum concentrations of low molecular weight metabolites was performed by gas chromatography mass spectrometry...
July 19, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28716362/phosphoenolpyruvate-phosphotransferase-system-components-positively-regulate-klebsiella-biofilm-formation
#14
Yu-Tze Horng, Chi-Jen Wang, Wen-Ting Chung, Huei-Jen Chao, Yih-Yuan Chen, Po-Chi Soo
BACKGROUND/PURPOSE: Klebsiella pneumoniae is one of the leading causes of device-related infections (DRIs), which are associated with attachment of bacteria to these devices to form a biofilm. The latter is composed of not only bacteria but also extracellular polymeric substances (EPSes) consisting of extracellular DNAs, polysaccharides, and other macromolecules. The phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS) regulates diverse processes of bacterial physiology...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28713420/modeling-the-metabolism-of-arabidopsis-thaliana-application-of-network-decomposition-and-network-reduction-in-the-context-of-petri-nets
#15
Ina Koch, Joachim Nöthen, Enrico Schleiff
Motivation:Arabidopsis thaliana is a well-established model system for the analysis of the basic physiological and metabolic pathways of plants. Nevertheless, the system is not yet fully understood, although many mechanisms are described, and information for many processes exists. However, the combination and interpretation of the large amount of biological data remain a big challenge, not only because data sets for metabolic paths are still incomplete. Moreover, they are often inconsistent, because they are coming from different experiments of various scales, regarding, for example, accuracy and/or significance...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28712602/anaplerotic-therapy-in-propionic-acidemia
#16
Nicola Longo, Leisa B Price, Eduard Gappmaier, Nancy L Cantor, Sharon L Ernst, Carrie Bailey, Marzia Pasquali
BACKGROUND: Propionic acidemia is a rare metabolic disorder caused by a deficiency of propionyl- CoA carboxylase, the enzyme converting propionyl-CoA to methylmalonyl-CoA that subsequently enters the citric acid cycle as succinyl-CoA. Patients with propionic acidemia cannot metabolize propionic acid, which combines with oxaloacetate to form methylcitric acid. This, with the defective supply of succinyl-CoA, may lead to a deficiency in citric acid cycle intermediates. PURPOSE: The objective of this study was to determine whether supplements with glutamine (400mg/kg per day), citrate (7...
July 12, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28690628/comparison-of-salt-tolerance-in-soja-based-on-metabolomics-of-seedling-roots
#17
Mingxia Li, Rui Guo, Yang Jiao, Xiaofei Jin, Haiyan Zhang, Lianxuan Shi
Soybean is an important economic crop that is continually threatened by abiotic stresses, especially salt stress. Wild soybean is an important germplasm resource for the breeding of cultivated soybean. The root system plays a very important role in plant salt tolerance. To explore the salt tolerance-related mechanisms among Soja, we have demonstrated the seedling roots' growth and metabolomics in wild soybean, semi-wild soybean, and cultivated soybean under two types of salt stress by using gas chromatography-mass spectrometry...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28688326/metabolic-peculiarities-of-the-citric-acid-overproduction-from-glucose-in-yeasts-yarrowia-lipolytica
#18
Svetlana V Kamzolova, Igor G Morgunov
Comparative study of 43 natural yeast strains belonging to 20 species for their capability for overproduction of citric acid (CA) from glucose under nitrogen limitation of cell growth was carried out. As a result, natural strain Yarrowia lipolytica VKM Y-2373 was selected. The effect of growth limitation by biogenic macroelements (nitrogen, phosphorus, or sulfur) on the CA production by the selected strain was studied. It was shown that yeasts Y. lipolytica grown under deficiency of nitrogen, phosphorus, or sulfur were able to excrete CA in industrially sufficient amounts (80-85g/L with the product yield (YCA) of 0...
June 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28674679/the-metabolic-phenotype-of-prostate-cancer
#19
REVIEW
Eric Eidelman, Jeffrey Twum-Ampofo, Jamal Ansari, Mohummad Minhaj Siddiqui
Prostate cancer is the most common non-cutaneous cancer in men in the United States. Cancer metabolism has emerged as a contemporary topic of great interest for improved mechanistic understanding of tumorigenesis. Prostate cancer is a disease model of great interest from a metabolic perspective. Prostatic tissue exhibits unique metabolic activity under baseline conditions. Benign prostate cells accumulate zinc, and this excess zinc inhibits citrate oxidation and metabolism within the citric acid cycle, effectively resulting in citrate production...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28673551/analyses-of-slc13a5-epilepsy-patients-reveal-perturbations-of-tca-cycle
#20
Matthew N Bainbridge, Erin Cooney, Marcus Miller, Adam D Kennedy, Jacob E Wulff, Taraka Donti, Shalini N Jhangiani, Richard A Gibbs, Sarah H Elsea, Brenda E Porter, Brett H Graham
OBJECTIVE: To interrogate the metabolic profile of five subjects from three families with rare, nonsense and missense mutations in SLC13A5 and Early Infantile Epileptic Encephalopathies (EIEE) characterized by severe, neonatal onset seizures, psychomotor retardation and global developmental delay. METHODS: Mass spectrometry of plasma, CSF and urine was used to identify consistently dysregulated analytes in our subjects. RESULTS: Distinctive elevations of citrate and dysregulation of citric acid cycle intermediates, supporting the hypothesis that loss of SLC13A5 function alters tricarboxylic acid cycle (TCA) metabolism and may disrupt metabolic compartmentation in the brain...
August 2017: Molecular Genetics and Metabolism
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