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citric acid cycle

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https://www.readbyqxmd.com/read/28093038/metabonomic-strategy-to-the-evaluation-of-chinese-medicine-salvia-miltiorrhiza-and-dalbergia-odorifera-interfering-myocardial-ischemia-reperfusion-injury-in-rats
#1
Fei Mu, Jialin Duan, Haixu Bian, Xiaohu Zhai, Peijin Shang, Rui Lin, Meina Zhao, Dongmei Hu, Ying Yin, Aidong Wen, Miaomiao Xi
Extract of Salvia miltiorrhiza and Dalbergia Odorifera (SM-DOO) has been traditionally used for the prevention and treatment of cardiovascular diseases. However, information regarding the pharmacodyamic material basis and potential mechanism remain unknown. Male Sprague-Dawley rats were divided into four groups: Sham, Model, Diltiazem and SM-DOO group, n=6. Rats were pretreated with homologous drugs for 7 days, then subjected to 30 min of ischemia followed by 180 min of reperfusion. Cardioprotection effects of SM-DOO on myocardial ischemia/reperfusion (MI/R) injury rats were examined by hemodynamic, infarct area, histopathology, biochemical indicators and western blot analysis...
January 16, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28073690/citrate-pathophysiology-and-metabolism
#2
REVIEW
Mehran Monchi
By chelating ionized calcium, citrate allows extracorporeal circuit anticoagulation without a bleeding risk for the patient. Citrate anticoagulation is also associated with a reduced activation of leucocytes and platelets. Citrate clearance by citric acid cycle (Krebs cycle) is not modified by renal failure, but is reduced by about 50% in patients with cirrhosis. Toxic effects of citrate result from a decrease in plasma ionized calcium of the patient. The first side effect is a prolongation of the QT interval...
December 30, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28056169/concomitant-leaching-and-electrochemical-extraction-of-rare-earth-elements-from-monazite
#3
Synthia Maes, Wei-Qin Zhuang, Korneel Rabaey, Lisa Alvarez-Cohen, Tom Hennebel
Rare earth elements (REEs) have become increasingly important in modern day technologies. Unfortunately, their recycling is currently limited, and the conventional technologies for their extraction and purification are exceedingly energy and chemical intensive. New sustainable technologies for REE extraction from both primary and secondary resources would be extremely beneficial. This research investigated a two-stage recovery strategy focused on the recovery of neodymium (Nd) and lanthanum (La) from monazite ore that combines microbially based leaching (using citric acid and spent fungal supernatant) with electrochemical extraction...
January 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28055179/a-non-natural-protein-rescues-cells-deleted-for-a-key-enzyme-in-central-metabolism
#4
Katherine M Digianantonio, Maria Korolev, Michael H Hecht
An important goal of synthetic biology is to create novel proteins that provide life-sustaining functions in living organisms. Recent attempts to produce novel proteins have focused largely on rational design involving significant computational efforts. In contrast, nature does not design sequences a priori. Instead, nature relies on Darwinian evolution to select biologically functional sequences from non-designed sequence space. To mimic natural selection in the laboratory, we combed through libraries of novel sequences and selected proteins that rescue E...
January 5, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28038423/citric-acid-application-for-denitrification-process-support-in-biofilm-reactor
#5
Artur Mielcarek, Joanna Rodziewicz, Wojciech Janczukowicz, Dorota Dabrowska, Slawomir Ciesielski, Arthur Thornton, Joanna Struk-Sokołowska
The study demonstrated that citric acid, as an organic carbon source, can improve denitrification in Anaerobic Sequencing Batch Biofilm Reactor (AnSBBR). The consumption rate of the organic substrate and the denitrification rate were lower during the period of the reactor's acclimatization (cycles 1-60; 71.5 mgCOD L(-1) h(-1) and 17.81 mgN L(-1) h(-1), respectively) than under the steady state conditions (cycles 61-180; 143.8 mgCOD L(-1) h(-1) and 24.38 mgN L(-1) h(-1)). The biomass yield coefficient reached 0...
December 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/28034986/influence-of-sexual-hormones-on-neural-orofacial-perception
#6
Bruna Alves, Flavia Ibuki, Alyne Simões Gonçalves, Manoel Jacobsen Teixeira, Silvia Regina Dowgan Tesseroli De Siqueira
OBJECTIVE  : To investigate the trigeminal somatosensory (thermal, pain, tactile, vibratory, and electric), gustative (salty, bitter, sweet, sour), and olfactory thresholds in healthy women during the menstrual cycle and investigate any association with estradiol and progesterone levels in saliva. METHODS : We examined/tested 39 women between age 19 and 47 years and with regular menstrual cycles and no comorbidities. All women were informed about the purposes of the study, and only those who signed the informed consent were included...
December 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28018404/functional-and-integrative-analysis-of-the-proteomic-profile-of-radish-root-under-pb-exposure
#7
Yan Wang, Liang Xu, Mingjia Tang, Haiyan Jiang, Wei Chen, Wei Zhang, Ronghua Wang, Liwang Liu
Lead (Pb) is one of the most abundant heavy metal (HM) pollutants, which can penetrate the plant through the root and then enter the food chain causing potential health risks for human beings. Radish is an important root vegetable crop worldwide. To investigate the mechanism underlying plant response to Pb stress in radish, the protein profile changes of radish roots respectively upon Pb(NO3)2 at 500 mg L(-1)(Pb500) and 1000 mg L(-1)(Pb1000), were comprehensively analyzed using iTRAQ (Isobaric Tag for Relative and Absolute Quantification)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28007948/genome-metabolite-associations-revealed-low-heritability-high-genetic-complexity-and-causal-relations-for-leaf-metabolites-in-winter-wheat-triticum-aestivum
#8
Andrea Matros, Guozheng Liu, Anja Hartmann, Yong Jiang, Yusheng Zhao, Huange Wang, Erhard Ebmeyer, Viktor Korzun, Ralf Schachschneider, Ebrahim Kazman, Johannes Schacht, Friedrich Longin, Jochen Christoph Reif, Hans-Peter Mock
We investigated associations between the metabolic phenotype, consisting of quantitative data of 76 metabolites from 135 contrasting winter wheat (Triticum aestivum) lines, and 17 372 single nucleotide polymorphism (SNP) markers. Metabolite profiles were generated from flag leaves of plants from three different environments, with average repeatabilities of 0.5-0.6. The average heritability of 0.25 was unaffected by the heading date. Correlations among metabolites reflected their functional grouping, highlighting the strict coordination of various routes of the citric acid cycle...
December 22, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27997141/neonatal-metabolomic-profiles-related-to-prenatal-arsenic-exposure
#9
Jessica E Laine, Kathryn A Bailey, Andrew F Olshan, Lisa Smeester, Zuzana Drobná, Miroslav Stýblo, Christelle Douillet, Gonzalo García-Vargas, Marisela Rubio-Andrade, Wimal Pathmasiri, Susan McRitchie, Susan J Sumner, Rebecca C Fry
Prenatal inorganic arsenic (iAs) exposure is associated with health effects evident at birth and later in life. An understanding of the relationship between prenatal iAs exposure and alterations in the neonatal metabolome could reveal critical molecular modifications, potentially underpinning disease etiologies. In this study, nuclear magnetic resonance (NMR) spectroscopy-based metabolomic analysis was used to identify metabolites in neonate cord serum associated with prenatal iAs exposure in participants from the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort, in Gómez Palacio, Mexico...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27996265/improved-cycling-performance-of-a-si-nanoparticle-anode-utilizing-citric-acid-as-a-surface-modifying-agent
#10
Cao Cuong Nguyen, Daniel M Seo, K W D K Chandrasiri, Brett L Lucht
Citric acid and its analogues have been investigated as surface-modifying agents for Si nanoparticle anodes using electrochemical cycling, attenuated total reflectance infrared (ATR IR), and X-ray photoelectron spectroscopy (XPS). A Si nanoparticle anode prepared with citric acid (CA) has better capacity retention than one containing 1,2,3,4-butanetetracarboxylic acid (BA), but both electrodes outperform Si-PVDF. The Si-CA anode has an initial specific capacity of 3530 mA h/g and a first cycle efficiency of 82%...
December 20, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27979739/genetic-variants-in-sirt3-transcriptional-regulatory-region-affect-promoter-activity-and-fat-deposition-in-three-cattle-breeds
#11
Linsheng Gui, Jieyun Hong, Sayed Haidar Abbas Raza, Linsen Zan
Sirtuin 3 (SIRT3) is a mitochondrial nicotinamide adenine dinucleotide (NAD)-dependent deacetylase. It has crucial roles in regulating the respiratory chain, in adenosine triphosphate (ATP) production, and in both the citric acid and urea cycles. The aim of this study was to investigate whether SIRT3 could be used as a candidate gene in the breeding of cattle. Expression analysis by quantitative real-time polymerase chain reactions (qPCR) indicated that expression levels of SIRT3 were highest in the kidney, rumen, liver, omasum and muscle...
December 12, 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/27958316/the-key-role-of-meteorites-in-the-formation-of-relevant-prebiotic-molecules-in-a-formamide-water-environment
#12
Luca Rotelli, Josep M Trigo-Rodríguez, Carles E Moyano-Cambero, Eleonora Carota, Lorenzo Botta, Ernesto Di Mauro, Raffaele Saladino
We show that carbonaceous chondrite meteorites actively and selectively catalyze the formation of relevant prebiotic molecules from formamide in aqueous media. Specific catalytic behaviours are observed, depending on the origin and composition of the chondrites and on the type of water present in the system (activity: thermal > seawater > pure). We report the one-pot synthesis of all the natural nucleobases, of aminoacids and of eight carboxylic acids (forming, from pyruvic acid to citric acid, a continuous series encompassing a large part of the extant Krebs cycle)...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27957274/effect-of-toothpastes-containing-different-naf-concentrations-or-a-snf2-naf-combination-on-root-dentine-erosive-lesions-in-vitro
#13
Iliana Diamanti, Haroula Koletsi-Kounari, Eleni Mamai-Homata
BACKGROUND: Fluoride toothpastes presumably offer some protection against acid erosion. However, uncertainty exists towards fluoride's efficacy relatively to the concentration and the type of chemical compound used. This in vitro study evaluated the relative efficacy of toothpastes containing sodium fluoride in different concentrations or a stabilized stannous fluoride/sodium fluoride system on root dentine erosion. MATERIAL AND METHODS: Bovine dentin specimens were allocated into four groups (n=10): control (no F), 1450ppm F (as NaF), 5000ppm F (as NaF) and 1450ppm F (1100ppm as stabilized SnF2 and 350ppm as NaF)/sodium hexamethaphosphate...
December 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27941349/lipotoxic-palmitate-impairs-the-rate-of-%C3%AE-oxidation-and-citric-acid-cycle-flux-in-rat-neonatal-cardiomyocytes
#14
Taha Haffar, Ali Akoumi, Nicolas Bousette
BACKGROUND/AIMS: Diabetic hearts exhibit intracellular lipid accumulation. This suggests that the degree of fatty acid oxidation (FAO) in these hearts is insufficient to handle the elevated lipid uptake. We previously showed that palmitate impaired the rate of FAO in primary rat neonatal cardiomyocytes. Here we were interested in characterizing the site of FAO impairment induced by palmitate since it may shed light on the metabolic dysfunction that leads to lipid accumulation in diabetic hearts...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27940340/inhibition-of-tyrosinase-by-fumaric-acid-integration-of-inhibition-kinetics-with-computational-docking-simulations
#15
Lin Gou, Jinhyuk Lee, Jun-Mo Yang, Yong-Doo Park, Hai-Meng Zhou, Yi Zhan, Zhi-Rong Lü
Fumaric acid (FA), which is naturally found in organisms, is a well known intermediate of the citric acid cycle. We evaluated the effects of FA on tyrosinase activity and structure via enzyme kinetics and computational simulations. FA was found to be a reversible inhibitor of tyrosinase and its induced mechanism was the parabolic non-competitive inhibition type with IC50=13.7±0.25mM and Kislope=12.64±0.75mM. We newly established the equation for the dissociation constant (Kislope) for the parabolic inhibition type in this study...
December 7, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27933436/emerging-biotechnologies-for-production-of-itaconic-acid-and-its-applications-as-a-platform-chemical
#16
REVIEW
Badal C Saha
Recently, itaconic acid (IA), an unsaturated C5-dicarboxylic acid, has attracted much attention as a biobased building block chemical. It is produced industrially (>80 g L(-1)) from glucose by fermentation with Aspergillus terreus. The titer is low compared with citric acid production (>200 g L(-1)). This review summarizes the latest progress on enhancing the yield and productivity of IA production. IA biosynthesis involves the decarboxylation of the TCA cycle intermediate cis-aconitate through the action of cis-aconitate decarboxylase (CAD) enzyme encoded by the CadA gene in A...
December 8, 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27928693/accumulation-of-lactate-in-the-rat-brain-during-hyperammonaemia-is-not-associated-with-impaired-mitochondrial-respiratory-capacity
#17
Anne Møller Witt, Fin Stolze Larsen, Peter Nissen Bjerring
In acute liver failure (ALF) cerebral oedema and high intracranial pressure (ICP) are potentially deadly complications. Astrocytes cultured in ammonia have shown mitochondrial dysfunction and in rat models of liver failure, de novo lactate production in the brain has been observed and has led to a hypothesis of compromised brain metabolism during ALF. In contrast, normal lactate levels are found in cerebral microdialysate of ALF patients and the oxygen: glucose ratio of cerebral metabolic rates remains normal...
December 7, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27908232/iron-sulfur-clusters-in-mitochondrial-metabolism-multifaceted-roles-of-a-simple-cofactor
#18
REVIEW
Johnny Stiban, Minyoung So, Laurie S Kaguni
Iron-sulfur metabolism is essential for cellular function and is a key process in mitochondria. In this review, we focus on the structure and assembly of mitochondrial iron-sulfur clusters and their roles in various metabolic processes that occur in mitochondria. Iron-sulfur clusters are crucial in mitochondrial respiration, in which they are required for the assembly, stability, and function of respiratory complexes I, II, and III. They also serve important functions in the citric acid cycle, DNA metabolism, and apoptosis...
October 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27886402/analysis-of-paracoccidioides-lutzii-mitochondria-a-proteomic-approach
#19
L Casaletti, P S Lima, L N Lima, C L Borges, S N Báo, A M Bailão, C M A Bailão
The genus Paracoccidioides is composed of thermal dimorphic fungi, causative agents of paracoccidioidomycosis, one of the most frequent systemic mycoses in Latin America. Mitochondria have sophisticated machinery for ATP production, which involves metabolic pathways such as citric acid and glyoxylate cycles, electron transport chain and oxidative phosphorylation. In addition, this organelle performs a variety of functions in the cell, working as an exceptional metabolic signaling center that contributes to cellular stress responses, as autophagy and apoptosis in eukaryotic organisms...
November 25, 2016: Yeast
https://www.readbyqxmd.com/read/27885626/anaplerosis-for-glutamate-synthesis-in-the-neonate-and-in-adulthood
#20
Eva Brekke, Tora Sund Morken, Anne B Walls, Helle Waagepetersen, Arne Schousboe, Ursula Sonnewald
A central task of the tricarboxylic acid (TCA, Krebs, citric acid) cycle in brain is to provide precursors for biosynthesis of glutamate, GABA, aspartate and glutamine. Three of these amino acids are the partners in the intricate interaction between astrocytes and neurons and form the so-called glutamine-glutamate (GABA) cycle. The ketoacids α-ketoglutarate and oxaloacetate are removed from the cycle for this process. When something is removed from the TCA cycle it must be replaced to permit the continued function of this essential pathway, a process termed anaplerosis...
2016: Advances in Neurobiology
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