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JOURNAL ARTICLE
Sarah Bagley, Dylan Glover, Jennifer Foreman, Scott Hadland, L J Punch, Darren Taichman
New England Journal of Medicine, Volume 390, Issue 4, January 2024.
January 25, 2024: New England Journal of Medicine
#22
JOURNAL ARTICLE
Justin J Fitzgerald, Marcus A Battraw, Michelle A James, Anita M Bagley, Jonathon S Schofield, Wilsaan M Joiner
Children with a unilateral congenital below elbow deficiency (UCBED) have one typical upper limb and one that lacks a hand, ending below the elbow at the proximal/mid forearm. UCBED is an isolated condition, and affected children otherwise develop normal sensorimotor control. Unlike adults with upper limb absence, the majority of whom have an acquired loss, children with UCBED never developed a hand, so their residual muscles have never actuated an intact limb. Their ability to purposefully modulate affected muscle activity is often assumed to be limited, and this assumption has influenced prosthetic design and prescription practices for this population as many modern devices derive control signals from affected muscle activity...
January 23, 2024: Journal of Neuroengineering and Rehabilitation
#23
REVIEW
Natasha Reid, Nykola Kent, Nicole Hewlett, Kerryn Bagley, Tracey W Tsang, Sarah Goldsbury, Robyn Williams, Lisa Akison, Lorelle Holland, Chelsea Vanderpeet, Michael Doyle, Nirosha Boaden, Nicole Hayes
We undertook a scoping review to identify the factors outside of current fetal alcohol spectrum disorder (FASD) diagnostic criteria to be considered as part of a holistic assessment process. This included physical, social, cultural, mental health and wellbeing factors to inform targeted recommendations and supports to improve outcomes for individuals with FASD. Evidence from this review will be used to inform the revision of the Australian Guide to the Diagnosis of FASD. Six electronic databases were searched...
November 2023: Alcohol Clin Exp Res (Hoboken)
#24
JOURNAL ARTICLE
Justin C Bagley, Cal C Johnson, Stuart W McGregor, Maria F Breitman, Jonathan W Armbruster, Phillip M Harris, Patrick E Oneil
Checklists are fundamental and important tools for organizing information about biodiversity that provide a basis for conservation and additional scientific research. While Alabama is recognized as an aquatic biodiversity hotspot with the highest native freshwater fish diversity in the contiguous United States, we currently lack an up-to-date list of the states fishes. In particular, much has changed over the past ~20 years regarding our knowledge of fishes from Alabama and the Mobile River Basin, rendering past comprehensive treatments by Mettee et al...
October 19, 2023: Zootaxa
#25
JOURNAL ARTICLE
Stephen J Bagley, Zev A Binder, Lamia Lamrani, Eliana Marinari, Arati S Desai, MacLean P Nasrallah, Eileen Maloney, Steven Brem, Robert A Lustig, Goldie Kurtz, Michelle Alonso-Basanta, Pierre-Emmanuel Bonté, Christel Goudot, Wilfrid Richer, Eliane Piaggio, Shawn Kothari, Lea Guyonnet, Coralie L Guerin, Joshua J Waterfall, Suyash Mohan, Wei-Ting Hwang, Oliver Y Tang, Meghan Logun, Meghna Bhattacharyya, Kelly Markowitz, Devora Delman, Amy Marshall, E John Wherry, Sebastian Amigorena, Gregory L Beatty, Jennifer L Brogdon, Elizabeth Hexner, Denis Migliorini, Cecile Alanio, Donald M O'Rourke
We previously showed that chimeric antigen receptor (CAR) T-cell therapy targeting epidermal growth factor receptor variant III (EGFRvIII) produces upregulation of programmed death-ligand 1 (PD-L1) in the tumor microenvironment (TME). Here we conducted a phase 1 trial (NCT03726515) of CAR T-EGFRvIII cells administered concomitantly with the anti-PD1 (aPD1) monoclonal antibody pembrolizumab in patients with newly diagnosed, EGFRvIII+ glioblastoma (GBM) (n = 7). The primary outcome was safety, and no dose-limiting toxicity was observed...
January 12, 2024: Nature Cancer
#26
JOURNAL ARTICLE
Sarah Bagley, Je'Mal Barnes, Barbara Blunt, Jennifer Foreman, Scott Hadland, Sandra Mayen, Raina McMahan, L J Punch, Darren Taichman
New England Journal of Medicine, Volume 390, Issue 2, January 2024.
January 11, 2024: New England Journal of Medicine
#27
JOURNAL ARTICLE
Caroline A King, Tamara Beetham, Natashia Smith, Honora Englander, Dana Button, Patrick C M Brown, Scott E Hadland, Sarah M Bagley, Olivia Rae Wright, P Todd Korthuis, Ryan Cook
Drug overdose deaths among adolescents are increasing in the United States. Residential treatment facilities are one treatment option for adolescents with substance use disorders, yet little is known about their accessibility or cost. Using the Substance Abuse and Mental Health Services Administration's treatment locator and search engine advertising data, we identified 160 residential addiction treatment facilities that treated adolescents with opioid use disorder as of December 2022. We called facilities while role-playing as the aunt or uncle of a sixteen-year-old child with a recent nonfatal overdose, to inquire about policies and costs...
January 2024: Health Affairs
#28
JOURNAL ARTICLE
B Soller, J M Martinez, H Rishel Brakey, N Mickel, A Sood
For faculty members, job satisfaction, compensation, and career advancement hinge on achieving 'critical' career milestones (e.g., external funding, tenure). Faculty face unique barriers to achieving career milestones (Bagley et al., 2018), and therefore must employ tailored strategies to overcome challenges. The current project extends research on barriers to career milestones (Soller et al., 2022) to examine strategies faculty employ to overcome barriers in the pursuit of critical career milestones. Thirty-seven faculty members participated across eight US academic institutions, including 22 under-represented minorities in science (URM-S; women or racial/ ethnic minorities)...
November 2023: The chronicle of mentoring & coaching
#29
JOURNAL ARTICLE
Corinne A Beaugard, Scott W Formica, Emily R Cummins, Sarah M Bagley, Leo Beletskey, Traci C Green, Stephen P Murray, Shapei Yan, Ziming Xuan, Alexander Y Walley, Jennifer J Carroll
BACKGROUND: Public health-public safety partnerships for post-overdose outreach have emerged in many communities to prevent future overdose events. These efforts often identify overdose survivors through emergency call data and seek to link them with relevant services. The aim of this study was to describe how post-overdose outreach programs in Massachusetts manage the confidentiality of identifiable information and privacy of survivors. METHODS: In 2019, 138 Massachusetts programs completed surveys eliciting responses to questions about program operations...
January 4, 2024: International Journal on Drug Policy
#30
REVIEW
George Bcharah, Nithin Gupta, Nicholas Panico, Spencer Winspear, Austin Bagley, Morgan Turnow, Randy D'Amico, Alvan-Emeka Ukachukwu
Neurosurgical technologies have become increasingly more adaptive, featuring real-time and patient-specific guidance in pre, intra, and postoperative settings. This review offers insight on how these integrative innovations compare to conventional approaches in spine surgery, focusing on Machine Learning (ML), Artificial Intelligence (AI), Augmented Reality (AR) and Virtual Reality (VR), and Spinal Navigation Systems. Data on technology applications, diagnostic and procedural accuracy, intraoperative times, radiation exposures, post-operative outcomes, and costs were extracted and compared to conventional methods to assess their advantages and limitations...
December 28, 2023: World Neurosurgery
#31
JOURNAL ARTICLE
Braden Hale Bagley, Candace Forbes Bright, Edward Sayre, Roma Hanks, Sarah Wraight
Guided by the problematic integration theory, the purpose of this study was to determine what probabilistic and evaluative orientations were formed during post-disaster decision-making following the 2010 Deepwater Horizon oil spill, the 2011 Tuscaloosa Tornado, the 2011 Mississippi Delta flooding, and a pair of tornados in Hattiesburg Mississippi in 2013 and 2017. A series of focus groups were conducted in communities impacted by these disasters. Five different themes emerged when coding the focus group data for probabilistic and evaluative orientations formed: (1) Distrust, (2) Disorientation, (3) Desperation, (4) Disparity, and (5) Disconnection...
2023: Qual Res Rep Commun
#32
JOURNAL ARTICLE
Marie Camerota, Jessica Bagley, Elisabeth C McGowan, Brian S Carter, Jennifer Check, Lynne M Dansereau, Sheri A DellaGrotta, Jennifer B Helderman, Julie A Hofheimer, Cynthia M Loncar, Charles R Neal, T Michael O'Shea, Steven L Pastyrnak, Lynne M Smith, Todd M Everson, Barry M Lester
OBJECTIVE: Broadband parent rating scales are commonly used to assess behavioral problems in children. Multiple rating scales are available, yet agreement between them is not well-understood. The objective of this study was to evaluate agreement between the Behavior Assessment System for Children, Third Edition (BASC-3), and Child Behavior Checklist 1.5 to 5 years (CBCL) in a sample of children born very preterm. METHOD: We assessed 73 children born < 30 weeks' gestational age whose caregivers completed the BASC-3 and CBCL at age 4...
December 20, 2023: Journal of Developmental and Behavioral Pediatrics: JDBP
#33
JOURNAL ARTICLE
Tudor Groza, Honghan Wu, Marcel E Dinger, Daniel Danis, Coleman Hilton, Anita Bagley, Jon R Davids, Ling Luo, Zhiyong Lu, Peter N Robinson
MOTIVATION: Methods for concept recognition (CR) in clinical texts have largely been tested on abstracts or articles from the medical literature. However, texts from electronic health records (EHRs) frequently contain spelling errors, abbreviations, and other non-standard ways of representing clinical concepts. RESULTS: Here, we present a method inspired by the BLAST algorithm for biosequence alignment that screens texts for potential matches on the basis of matching k-mer counts and scores candidates based on conformance to typical patterns of spelling errors derived from 2...
November 24, 2023: Bioinformatics
#34
JOURNAL ARTICLE
Ali Nabavizadeh, Stephen J Bagley
In this CCR Translations, we discuss pharmacological ascorbate as a novel therapeutic for glioblastoma. Aberrant iron metabolism in glioblastoma can be assessed noninvasively by MRI and exploited to potentially improve the efficacy of chemoradiotherapy. We contextualize the study's results and discuss the next steps to further develop this paradigm.
November 20, 2023: Clinical Cancer Research
#35
JOURNAL ARTICLE
Alice E Coyne, Elsa Mattson, Jenna M Bagley, Alexandra B Klein, Kathy Shekhtman, Sinan Payat, Daniella S Levine, Norah C Feeny, Lori A Zoellner
OBJECTIVE: Difficulties with emotion regulation (ER) are a risk factor for the development and maintenance of posttraumatic stress disorder (PTSD). Less is known about temporal relations between ER and PTSD symptom change during treatment, including whether ER may represent a more potent change ingredient for some patients relative to others. This study examined the association between within-patient changes in ER and next-session PTSD symptom change and whether this association was more pronounced for patients with poorer baseline ER, more severe depression, or higher borderline personality disorder symptoms...
November 16, 2023: Journal of Consulting and Clinical Psychology
#36
JOURNAL ARTICLE
Faraaz Azam, Soummitra Anand, Anthony Dragun, Kailee Furtado, Madelina Nguyen, Ishav Shukla, William H Hicks, Kristen Hall, Omar S Akbik, Carlos A Bagley
BACKGROUND AND IMPORTANCE: Adult spinal deformity (ASD) is becoming increasingly common in aging populations. Patient-reported outcome measures (PROMs) are self-reported patient surveys administered pre- and post-operatively that provide insight into patient improvement. We aim to compare three of the most utilized PROMs: PROMIS-29, Oswestry Disability Index (ODI), and Visual Analogue Scale (VAS), to investigate whether they provide unique and independent assessments of patient outcomes when assessed longitudinally...
November 13, 2023: World Neurosurgery
#37
REVIEW
Nastaran Khalili, Hossein Shooli, Nastaran Hosseini, Anahita Fathi Kazerooni, Ariana Familiar, Sina Bagheri, Hannah Anderson, Stephen J Bagley, Ali Nabavizadeh
Clinical management in neuro-oncology has changed to an integrative approach that incorporates molecular profiles alongside histopathology and imaging findings. While the World Health Organization (WHO) guideline recommends the genotyping of informative alterations as a routine clinical practice for central nervous system (CNS) tumors, the acquisition of tumor tissue in the CNS is invasive and not always possible. Liquid biopsy is a non-invasive approach that provides the opportunity to capture the complex molecular heterogeneity of the whole tumor through the detection of circulating tumor biomarkers in body fluids, such as blood or cerebrospinal fluid (CSF)...
October 29, 2023: Cancers
#38
JOURNAL ARTICLE
Michael A Gargano, Nicolas Matentzoglu, Ben Coleman, Eunice B Addo-Lartey, Anna V Anagnostopoulos, Joel Anderton, Paul Avillach, Anita M Bagley, Eduard Bakštein, James P Balhoff, Gareth Baynam, Susan M Bello, Michael Berk, Holli Bertram, Somer Bishop, Hannah Blau, David F Bodenstein, Pablo Botas, Kaan Boztug, Jolana Čady, Tiffany J Callahan, Rhiannon Cameron, Seth J Carbon, Francisco Castellanos, J Harry Caufield, Lauren E Chan, Christopher G Chute, Jaime Cruz-Rojo, Noémi Dahan-Oliel, Jon R Davids, Maud de Dieuleveult, Vinicius de Souza, Bert B A de Vries, Esther de Vries, J Raymond DePaulo, Beata Derfalvi, Ferdinand Dhombres, Claudia Diaz-Byrd, Alexander J M Dingemans, Bruno Donadille, Michael Duyzend, Reem Elfeky, Shahim Essaid, Carolina Fabrizzi, Giovanna Fico, Helen V Firth, Yun Freudenberg-Hua, Janice M Fullerton, Davera L Gabriel, Kimberly Gilmour, Jessica Giordano, Fernando S Goes, Rachel Gore Moses, Ian Green, Matthias Griese, Tudor Groza, Weihong Gu, Julia Guthrie, Benjamin Gyori, Ada Hamosh, Marc Hanauer, Kateřina Hanušová, Yongqun Oliver He, Harshad Hegde, Ingo Helbig, Kateřina Holasová, Charles Tapley Hoyt, Shangzhi Huang, Eric Hurwitz, Julius O B Jacobsen, Xiaofeng Jiang, Lisa Joseph, Kamyar Keramatian, Bryan King, Katrin Knoflach, David A Koolen, Megan L Kraus, Carlo Kroll, Maaike Kusters, Markus S Ladewig, David Lagorce, Meng-Chuan Lai, Pablo Lapunzina, Bryan Laraway, David Lewis-Smith, Xiarong Li, Caterina Lucano, Marzieh Majd, Mary L Marazita, Victor Martinez-Glez, Toby H McHenry, Melvin G McInnis, Julie A McMurry, Michaela Mihulová, Caitlin E Millett, Philip B Mitchell, Veronika Moslerová, Kenji Narutomi, Shahrzad Nematollahi, Julian Nevado, Andrew A Nierenberg, Nikola Novák Čajbiková, John I Nurnberger, Soichi Ogishima, Daniel Olson, Abigail Ortiz, Harry Pachajoa, Guiomar Perez de Nanclares, Amy Peters, Tim Putman, Christina K Rapp, Ana Rath, Justin Reese, Lauren Rekerle, Angharad M Roberts, Suzy Roy, Stephan J Sanders, Catharina Schuetz, Eva C Schulte, Thomas G Schulze, Martin Schwarz, Katie Scott, Dominik Seelow, Berthold Seitz, Yiping Shen, Morgan N Similuk, Eric S Simon, Balwinder Singh, Damian Smedley, Cynthia L Smith, Jake T Smolinsky, Sarah Sperry, Elizabeth Stafford, Ray Stefancsik, Robin Steinhaus, Rebecca Strawbridge, Jagadish Chandrabose Sundaramurthi, Polina Talapova, Jair A Tenorio Castano, Pavel Tesner, Rhys H Thomas, Audrey Thurm, Marek Turnovec, Marielle E van Gijn, Nicole A Vasilevsky, Markéta Vlčková, Anita Walden, Kai Wang, Ron Wapner, James S Ware, Addo A Wiafe, Samuel A Wiafe, Lisa D Wiggins, Andrew E Williams, Chen Wu, Margot J Wyrwoll, Hui Xiong, Nefize Yalin, Yasunori Yamamoto, Lakshmi N Yatham, Anastasia K Yocum, Allan H Young, Zafer Yüksel, Peter P Zandi, Andreas Zankl, Ignacio Zarante, Miroslav Zvolský, Sabrina Toro, Leigh C Carmody, Nomi L Harris, Monica C Munoz-Torres, Daniel Danis, Christopher J Mungall, Sebastian Köhler, Melissa A Haendel, Peter N Robinson
The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English...
January 5, 2024: Nucleic Acids Research
#39
JOURNAL ARTICLE
Faraaz Azam, Kailee Furtado, Soummitra Anand, Anthony Dragun, Madelina Nguyen, Ishav Shukla, William H Hicks, Kristen Hall, Omar Akbik, Carlos A Bagley
BACKGROUND: and Importance: Patients with adult spinal deformity (ASD) undergoing operative treatment may have varying degrees of improvement in patient-reported outcomes. The Oswestry Disability Index (ODI) assesses improvement in quality of life. We aim to measure longitudinal outcomes of ODI scores over three years to determine if early ODI scores predict late ODI scores and to analyze longitudinal changes in ODI scores. METHODS: 235 patients above the age of 18 who underwent surgical correction of ASD at a single institution from 2016 to 2021 and completed ODI questionnaires at follow-up appointments met inclusion criteria...
November 10, 2023: World Neurosurgery
#40
REVIEW
Jessica B Foster, Mateusz P Koptyra, Stephen J Bagley
PURPOSE OF REVIEW: Given the invasive and high-risk nature of brain surgery, the need for non-invasive biomarkers obtained from the peripheral blood is greatest in tumors of the central nervous system (CNS). In this comprehensive review, we highlight recent advances in blood biomarker development for adult and pediatric brain tumors. RECENT FINDINGS: We summarize recent blood biomarker development for CNS tumors across multiple key analytes, including peripheral blood mononuclear cells, cell-free DNA, cell-free RNA, proteomics, circulating tumor cells, and tumor-educated platelets...
December 2023: Current Neurology and Neuroscience Reports
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