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https://www.readbyqxmd.com/read/29031030/ectopic-bone-as-a-nidus-for-calcium-oxalate-urocystolithiasis-in-a-cat
#1
J P Lulich, H S Prasad, M Manno, B Bagley
A 7-year-old female spayed domestic shorthair cat was referred to the urology service for nonsurgical urocystolith removal. A urolith was attached to the urothelium by ectopic bone. Interventional removal without surgery was successful. Follow-up evaluation 3 years after urolith removal revealed recurrent uroliths, bladder wall mineralization, and marked renal mineralization. This case illustrates the metaplastic potential of the urothelium and that ectopic bone should be included among the pathological factors that promote lithogenesis...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28973659/perfluorooctane-sulfonate-induced-hepatic-steatosis-in-male-sprague-dawley-rats-is-not-attenuated-by-dietary-choline-supplementation
#2
Bradford D Bagley, Shu-Ching Chang, David J Ehresman, Alan Eveland, Jeremiah Zitzow, George A Parker, Jeffrey M Peters, Kendall B Wallace, John L Butenhoff
Perfluorooctane sulfonate (PFOS) is an environmentally persistent chemical. Dietary 100 ppm PFOS fed to male mice and rats for four weeks caused hepatic steatosis through an unknown mechanism. Choline deficient diets can cause hepatic steatosis. A hepatic choline:PFOS ion complex was hypothesized to cause this effect in mice. This study tested whether dietary choline supplementation attenuates PFOS-induced hepatic steatosis in rats. Sprague Dawley rats (12/sex/group) were fed control, choline supplemented (CS), 100 ppm PFOS, or 100 ppm PFOS + CS diets for three weeks...
August 30, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28972020/innovative-contracting-for-pharmaceuticals-and-medicaid-s-best-price-rule
#3
Rachel Sachs, Nicholas Bagley, Darius N Lakdawalla
In recent years, drug manufacturers and private payers have expressed interest in novel pricing models that more closely link a drug's price to its value. Indication-based pricing, outcome-based pricing, drug licenses, and drug mortgages have all been discussed as alternatives to paying strictly for volume. Manufacturers and payers have complained, however, that Medicaid's "best-price rule" inhibits their ability to enter into these new pricing arrangements. This article examines the best-price rule and assesses to what extent, if any, it might frustrate the goal of paying for value...
September 28, 2017: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/28964830/causal-effects-of-cardiovascular-risk-factors-on-onset-of-major-age-related-diseases-a-time-to-event-mendelian-randomization-study
#4
Liang He, Irina Culminskaya, Yury Loika, Konstantin G Arbeev, Olivia Bagley, Matt Duan, Anatoliy I Yashin, Alexander M Kulminski
BACKGROUNDS: Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures. METHODS: We conducted two-stage time-to-event Mendelian randomization meta-analyses combining five large-scale longitudinal cohorts to investigate dynamic causal effects of cardiovascular disease risk factors including body mass index (BMI), systolic blood pressure (SBP), and lipids on the age-at-onset of age-related diseases...
September 28, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28960161/geriatric-comanagement-reduces-perioperative-complications-and-shortens-duration-of-hospital-stay-after-lumbar-spine-surgery-a-prospective-single-institution-experience
#5
Owoicho Adogwa, Aladine A Elsamadicy, Victoria D Vuong, Jessica Moreno, Joseph Cheng, Isaac O Karikari, Carlos A Bagley
OBJECTIVE Geriatric patients undergoing lumbar spine surgery have unique needs due to the physiological changes of aging. They are at risk for adverse outcomes such as delirium, infection, and iatrogenic complications, and these complications, in turn, contribute to the risk of functional decline, nursing home admission, and death. Whether preoperative and perioperative comanagement by a geriatrician reduces the incidence of in-hospital complications and length of in-hospital stay after elective lumbar spine surgery remains unknown...
September 29, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28952977/to-improve-substance-use-disorder-prevention-treatment-and-recovery-engage-the-family
#6
Alicia S Ventura, Sarah M Bagley
: Approximately 21 million people in the United States have a substance use disorder (SUD); the number of family members impacted by a loved one's SUD is exponentially greater. Affected family members of individuals with SUDs are at high risk for developing chronic medical and psychiatric health conditions, are high utilizers of the health care system, and have high health care expenditures. Family members play a central role in the lives of many individuals with SUDs; information given to family members can have a significant impact on persons with addiction and therefore the SUD treatment that an individual might receive...
August 4, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28939359/streptococcus-suis-meningitis-can-require-a-prolonged-treatment-course
#7
Jean Dejace, Emily Wood, Patrick Bagley
We report a case of recrudescent Streptococcus suis meningitis requiring a prolonged treatment course. A few similar cases can be found in the burgeoning literature on what remains a relatively uncommon disease in humans, and these patients should be monitored carefully upon completion of therapy.
September 19, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28902101/early-ambulation-decreases-length-of-hospital-stay-perioperative-complications-and-improves-functional-outcomes-in-elderly-patients-undergoing-surgery-for-correction-of-adult-degenerative-scoliosis
#8
Owoicho Adogwa, Aladine A Elsamadicy, Jared Fialkoff, Joseph Cheng, Isaac O Karikari, Carlos Bagley
STUDY DESIGN: Ambispective cohort review. OBJECTIVE: To examine the effects of early mobilization on patient outcomes, complications profile, and 30-day readmission rates. SUMMARY OF BACKGROUND DATA: Prolonged immobilization after surgery can result in functional decline and an increased risk of hospital-associated complications. METHODS: We conducted an ambispective study of 125 elderly patients (>65 years) undergoing elective spinal surgery for correction of adult degenerative scoliosis...
September 15, 2017: Spine
https://www.readbyqxmd.com/read/28901218/four-week-dietary-supplementation-with-10-and-or-15-fold-basal-choline-caused-decreased-body-weight-in-sprague-dawley-rats
#9
Bradford D Bagley, Shu-Ching Chang, David J Ehresman, Alan Eveland, George A Parker, Jeffrey M Peters, John L Butenhoff
Choline is an essential nutrient utilized for phosphatidylcholine biosynthesis and lipoprotein packaging and secretion. Recently, choline supplementation has been used by athletes and the public for weight loss. However, the potential toxicological impact of choline dietary supplementation requires further investigation. This study examined the effects of choline dietary supplementation in Sprague Dawley rats for 4 weeks. Rats were fed diets containing basal choline levels (control) or 5-, 10-, or 15-fold (5×, 10×, or 15×) basal diet concentration...
October 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28900588/correction-hydration-status-as-a-predictor-of-high-altitude-mountaineering-performance
#10
Eric Ladd, Katherine M Shea, Patrick Bagley, Paul S Auerbach, Elizabeth A Pirrotta, Ewen Wang, Grant Lipman
[This corrects the article DOI: 10.7759/cureus.918.].
September 8, 2017: Curēus
https://www.readbyqxmd.com/read/28893507/race-as-a-predictor-of-postoperative-hospital-readmission-after-spine-surgery
#11
Joel R Martin, Timothy Y Wang, Daniel Loriaux, Rupen Desai, Maragatha Kuchibhatla, Isaac O Karikari, Carlos A Bagley, Oren N Gottfried
Hospital readmission after surgery results in a substantial economic burden, and several recent studies have investigated the impact of race and ethnicity on hospital readmission rates, with the goal to identify hospitals and patients with high readmission risk. This single-institution, retrospective cohort study assesses the impact of race, along with other risk factors, on 30-day readmission rates following spinal surgery. This study is a single-institution retrospective cohort study with accrual from January 1, 2008, to December 31, 2010...
September 8, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28836959/strategies-for-improving-approximate-bayesian-computation-tests-for-synchronous-diversification
#12
Isaac Overcast, Justin C Bagley, Michael J Hickerson
BACKGROUND: Estimating the variability in isolation times across co-distributed taxon pairs that may have experienced the same allopatric isolating mechanism is a core goal of comparative phylogeography. The use of hierarchical Approximate Bayesian Computation (ABC) and coalescent models to infer temporal dynamics of lineage co-diversification has been a contentious topic in recent years. Key issues that remain unresolved include the choice of an appropriate prior on the number of co-divergence events (Ψ), as well as the optimal strategies for data summarization...
August 24, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28829860/why-it-s-so-hard-for-insurers-to-compete-over-technology
#13
Austin B Frakt, Nicholas Bagley
No abstract text is available yet for this article.
August 22, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28826716/relationship-between-koenig-depression-scale-and-post-operative-outcomes-ambulation-and-perception-of-pain-in-elderly-patients-%C3%A2-65-years-undergoing-elective-spinal-surgery-for-adult-scoliosis
#14
Aladine A Elsamadicy, Owoicho Adogwa, Amanda R Sergesketter, Collin Black, Aaron Tarnasky, Michael O Ongele, Victoria D Vuong, Syed Khalid, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: The aim of this study was to assess whether the Koenig Depression Scale (KDS) can identify depressed elderly patients undergoing elective spine surgery for deformity at-risk for inferior postoperative outcomes, including complication rates, ambulation ability, and patient reported outcomes. METHODS: The medical records of 92 elderly patients (≥65-years) undergoing a planned elective spinal surgery for correction of adult degenerative scoliosis were reviewed for this study...
August 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28792848/small-change-big-consequences-partial-medicaid-expansions-under-the-aca
#15
Adrianna McIntyre, Allan M Joseph, Nicholas Bagley
Though congressional efforts to repeal and replace the Affordable Care Act (ACA) seem to have stalled, the Trump administration retains broad executive authority to reshape the health care landscape. Perhaps the most consequential choices that the administration will make pertain to Medicaid, which..
September 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28790002/reduced-impact-of-smoking-status-on-30-day-complication-and-readmission-rates-after-elective-spinal-fusion-%C3%A2-3-levels-for-adult-spine-deformity-a-single-institutional-study-of-839-patients
#16
Aladine A Elsamadicy, Owoicho Adogwa, Amanda Sergesketter, Victoria D Vuong, Emily Lydon, Shay Behrens, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: Smoking status has been shown to affect postoperative outcomes after surgery. The aim of this study is to determine if patients' smoking status impacts 30-day complication and re-admission rates after elective complex spinal fusion (≥3 levels). METHODS: The medical records of 839 adult spinal deformity patients undergoing elective complex spinal fusion (≥3 levels) at a major academic institution from 2005 to 2015 were reviewed. We identified 124(14...
August 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28767537/addressing-stigma-in-medication-treatment-of-adolescents-with-opioid-use-disorder
#17
Sarah M Bagley, Scott E Hadland, Brittany L Carney, Richard Saitz
: In September 2016, the American Academic of Pediatrics released a policy statement that adolescents with opioid use disorder should be offered pharmacotherapy with buprenorphine/naloxone, methadone, or naltrexone. In our clinical practice, however, we have encountered the perception among patients, families, and clinicians alike that medications should be used as a last resort. That we should wait until things get worse is a discarded approach. As addiction specialists, it is imperative that we prevent and identify risky use and use disorders, then intervene early and offer timely, evidence-based treatment...
August 1, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28742285/variable-expressivity-and-incomplete-penetrance-in-a-large-family-with-non-classical-diamond-blackfan-anemia-associated-with-ribosomal-protein-l11-splicing-variant
#18
Colleen M Carlston, Zeinab A Afify, Janice C Palumbos, Heidi Bagley, Carlos Barbagelata, Whitney L Wooderchak-Donahue, Rong Mao, John C Carey
Diamond-Blackfan anemia (DBA) is a group of clinically and genetically heterogeneous bone marrow failure disorders with or without congenital anomalies. Variable expressivity and incomplete penetrance have been observed within affected families. Diamond-Blackfan anemia-7 (DBA7), caused by heterozygous mutations in ribosomal protein L11 (RPL11), accounts for approximately 5% of DBA. DBA7 is usually characterized by early-onset bone marrow failure often accompanied by congenital malformations, especially thumb defects...
July 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28727661/comparison-of-post-cesarean-section-opioid-analgesic-requirements-in-women-with-opioid-use-disorder-treated-with-methadone-or-buprenorphine
#19
Annmarie L Vilkins, Sarah M Bagley, Kristen A Hahn, Florencia Rojas-Miguez, Elisha M Wachman, Kelley Saia, Daniel P Alford
OBJECTIVE: Buprenorphine is a highly effective treatment for opioid use disorders, but its continuation in the perioperative setting remains controversial, unlike the accepted practice of perioperative methadone continuation. METHODS: We conducted a retrospective cohort study from 2006 to 2014 comparing post-cesarean section opioid analgesic requirements of women with opioid use disorders treated with methadone or buprenorphine. Preoperative, intraoperative, and postoperative opioid requirements (morphine equivalent dose [MED]), postoperative complications, and length of stay were compared between the methadone and buprenorphine groups...
September 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28722055/the-amyloid-architecture-provides-a-scaffold-for-enzyme-like-catalysts
#20
Z S Al-Garawi, B A McIntosh, D Neill-Hall, A A Hatimy, S M Sweet, M C Bagley, L C Serpell
Natural biological enzymes possess catalytic sites that are generally surrounded by a large three-dimensional scaffold. However, the proportion of the protein molecule that participates in the catalytic reaction is relatively small. The generation of artificial or miniature enzymes has long been a focus of research because enzyme mimetics can be produced with high activity at low cost. These enzymes aim to mimic the active sites without the additional architecture contributed by the protein chain. Previous work has shown that amyloidogenic peptides are able to self-assemble to create an active site that is capable of binding zinc and catalysing an esterase reaction...
August 3, 2017: Nanoscale
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