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https://www.readbyqxmd.com/read/28086944/prenatal-treatment-for-opioid-dependency-observations-from-a-large-inner-city-clinic
#1
Kelley Saia, Sarah M Bagley, Elisha M Wachman, Payal P Patel, Marisa D Nadas, Susan B Brogly
BACKGROUND: The objective of this study was to review changes in the prevalence of opioid use disorder in pregnancy, and to describe the prenatal care and neonatal outcomes following the implementation of buprenorphine treatment at a large US obstetrical clinic during the on-going opioid epidemic. METHODS: We conducted a retrospective cohort study of 310 women (332 pregnancies) with opioid use disorders and their neonates delivered between June 2006 and December 2010 at an obstetrical clinic in the US...
January 13, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28028850/history-geography-and-host-use-shape-genome-wide-patterns-of-genetic-variation-in-the-redheaded-pine-sawfly-neodiprion-lecontei
#2
Robin K Bagley, Vitor C Sousa, Matthew L Niemiller, Catherine R Linnen
Divergent host use has long been suspected to drive population differentiation and speciation in plant-feeding insects. Evaluating the contribution of divergent host use to genetic differentiation can be difficult, however, as dispersal limitation and population structure may also influence patterns of genetic variation. In this study, we use double-digest restriction-associated DNA (ddRAD) sequencing to test the hypothesis that divergent host use contributes to genetic differentiation among populations of the redheaded pine sawfly (Neodiprion lecontei), a widespread pest that uses multiple Pinus hosts throughout its range in eastern North America...
December 28, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/28003170/impact-of-race-on-30-day-complication-rates-after-elective-complex-spinal-fusion-%C3%A2-5-levels-a-single-institutional-study-of-446-patients
#3
Aladine A Elsamadicy, Owoicho Adogwa, Amanda Sergesketter, Cassie Hobbs, Shay Behrens, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
OBJECTIVE: Racial disparities have been demonstrated to affect surgical outcomes. However, the effect of race on complex spinal fusion outcomes remains understudied. The aim of this study is to determine if patient race impacts 30-day complication rates after elective complex spinal fusion (≥5 levels). METHODS: The medical records of 490 adult spinal deformity patients undergoing elective complex spinal fusion (≥5 levels) at a major academic institution from 2005 to 2015 were reviewed...
December 18, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28002116/crossing-borders-an-online-interdisciplinary-course-in-health-informatics-for-students-from-two-countries
#4
Mariann Fossum, Ann Fruhling, Carl Erik Moe, Cheryl Bagley Thompson
A cross-countries and interprofessional novel approach for delivering an international interdisciplinary graduate health informatics course online is presented. Included in this discussion are the challenges, lessons learned, and pedagogical recommendations from the experiences of teaching the course. Four professors from three different fields and from three universities collaborated in offering an international health informatics course for an interdisciplinary group of 18 US and seven Norwegian students...
December 20, 2016: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/27984439/skeletal-muscle-fatigability-and-myosin-heavy-chain-fiber-type-in-resistance-trained-men
#5
James R Bagley, Kathryn A McLeland, Jose A Arevalo, Lee E Brown, Jared W Coburn, Andrew J Galpin
Forty years ago, Thorstensson and Karlsson (1976) described the link between muscle fatigability and fiber type, finding that more fast-twitch fibers were associated with a quicker onset of quadriceps fatigue. This provided the foundation for the Classic Thorstensson Test (CT) of fatigability and subsequent noninvasive fiber type prediction equation. This equation was developed with data from recreationally active (REC) men, but has been implemented in participants with heterogeneous physical activity/exercise backgrounds...
December 7, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27984277/impact-of-hyperlipidemia-on-alloimmunity
#6
Jessamyn Bagley, Jin Yuan, John Iacomini
PURPOSE OF REVIEW: Hyperlipidemia is a comorbidity affecting a significant number of transplant patients despite treatment with cholesterol lowering drugs. Recently, it has been shown that hyperlipidemia can significantly alter T-cell responses to cardiac allografts in mice, and graft rejection is accelerated in dyslipidemic mice. Here, we review recent advances in our understanding of hyperlipidemia in graft rejection. RECENT FINDINGS: Hyperlipidemic mice have significant increases in serum levels of proinflammatory cytokines, and neutralization of interleukin 17 (IL-17) slows graft rejection, suggesting that IL-17 production by Th17 cells was necessary but not sufficient for rejection...
February 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/27959725/trouble-on-the-exchanges-does-the-united-states-owe-billions-to-health-insurers
#7
Nicholas Bagley
Yet another bruising fight has erupted over health care reform. On September 9, 2016, the Obama administration offered to open settlement negotiations with health insurers that have sued the United States to recover billions of dollars that they claim they are owed. Congressional Republicans are..
November 24, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27935321/neighborhood-economic-deprivation-and-social-fragmentation-associations-with-children-s-sleep
#8
Erika J Bagley, Thomas E Fuller-Rowell, Ekjyot K Saini, Lauren E Philbrook, Mona El-Sheikh
BACKGROUND & OBJECTIVE: A growing body of work indicates that experiences of neighborhood disadvantage place children at risk for poor sleep. This study aimed to examine how both neighborhood economic deprivation (a measure of poverty) and social fragmentation (an index of instability) are associated with objective measures of the length and quality of children's sleep. PARTICIPANTS: Participants were 210 children (54.3% boys) living predominantly in small towns and semirural communities in Alabama...
December 9, 2016: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/27911511/assisting-veterans-with-employment
#9
Chistopher Bagley, James B Reed
No abstract text is available yet for this article.
October 2016: NCSL Legisbrief
https://www.readbyqxmd.com/read/27900150/sex-differences-in-the-effects-of-12%C3%A2-weeks-sprint-interval-training-on-body-fat-mass-and-the-rates-of-fatty-acid-oxidation-and-vo2max-during-exercise
#10
Liam Bagley, Mark Slevin, Steven Bradburn, Donghui Liu, Chris Murgatroyd, George Morrissey, Michael Carroll, Mathew Piasecki, William S Gilmore, Jamie S McPhee
BACKGROUND: The purpose of this study was to examine whether very short duration, very high intensity sprint interval training (SIT) leads to loss of body fat mass in association with improvements to VO2max and fatty acid oxidation, and to assess the extent of sex dimorphism in these physiological responses. METHODS: A total of 24 men and 17 women (mean (SEM) age: 39 (±2) years; body mass index 24.6 (0.6)) completed measurements of the maximal rate of oxygen uptake (VO2max) and fatty acid oxidation (FATmax)...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27863923/pretreatment-red-blood-cell-total-folate-concentration-is-associated-with-response-to-pemetrexed-in-stage-iv-nonsquamous-non-small-cell-lung-cancer
#11
Stephen J Bagley, Steven Vitale, Suhong Zhang, Charu Aggarwal, Tracey L Evans, Evan W Alley, Roger B Cohen, Corey J Langer, Ian A Blair, Anil Vachani, Alexander S Whitehead
INTRODUCTION: Pemetrexed inhibits folate-dependent enzymes involved in pyrimidine and purine synthesis. Previous studies of genetic variation in these enzymes as predictors of pemetrexed efficacy have yielded inconsistent results. We investigated whether red blood cell (RBC) total folate, a phenotypic rather than genotypic, marker of cellular folate status was associated with the response to pemetrexed-based chemotherapy in advanced nonsquamous non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: We conducted a prospective cohort study of patients with stage IV nonsquamous NSCLC receiving first-line chemotherapy containing pemetrexed...
October 26, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27857857/predictive-parameters-for-the-antecedent-development-of-hip-pathology-associated-with-long-segment-fusions-to-the-pelvis-for-the-treatment-of-adult-spinal-deformity
#12
Merritt D Kinon, Rani Nasser, Jonathan P Nakhla, Owoicho Adogwa, Jessica R Moreno, Michael Harowicz, Terence Verla, Reza Yassari, Carlos A Bagley
BACKGROUND: The surgical treatment of adult scoliosis frequently involves long segment fusions across the lumbosacral joints that redistribute tremendous amounts of force to the remaining mobile spinal segments as well as to the pelvis and hip joints. Whether or not these forces increase the risk of femoral bone pathology remains unknown. The aim of this study is to determine the correlation between long segment spinal fusions to the pelvis and the antecedent development of degenerative hip pathologies as well as what predictive patient characteristics, if any, correlate with their development...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27832070/pleiotropic-associations-of-allelic-variants-in-a-2q22-region-with-risks-of-major-human-diseases-and-mortality
#13
Alexander M Kulminski, Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G Arbeev, Elena Loiko, Liubov Arbeeva, Olivia Bagley, Matt Duan, Arseniy Yashkin, Fang Fang, Mikhail Kovtun, Svetlana V Ukraintseva, Deqing Wu, Anatoliy I Yashin
Gaining insights into genetic predisposition to age-related diseases and lifespan is a challenging task complicated by the elusive role of evolution in these phenotypes. To gain more insights, we combined methods of genome-wide and candidate-gene studies. Genome-wide scan in the Atherosclerosis Risk in Communities (ARIC) Study (N = 9,573) was used to pre-select promising loci. Candidate-gene methods were used to comprehensively analyze associations of novel uncommon variants in Caucasians (minor allele frequency~2...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27813404/high-throughput-discovery-of-aptamers-for-sandwich-assays
#14
Andrew T Csordas, Anna Jørgensen, Jinpeng Wang, Emily Gruber, Qiang Gong, Elizabeth R Bagley, Margaret A Nakamoto, Michael Eisenstein, H Tom Soh
Sandwich assays are among the most powerful tools in molecular detection. These assays use "pairs" of affinity reagents so that the detection signal is generated only when both reagents bind simultaneously to different sites on the target molecule, enabling highly sensitive and specific measurements in complex samples. Thus, the capability to efficiently screen affinity reagent pairs at a high throughput is critical. In this work, we describe an experimental strategy for screening "aptamer pairs" at a throughput of 10(6) aptamer pairs per hour-which is many orders of magnitude higher than the current state of the art...
November 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27790247/pleiotropic-meta-analyses-of-longitudinal-studies-discover-novel-genetic-variants-associated-with-age-related-diseases
#15
Liang He, Yelena Kernogitski, Irina Kulminskaya, Yury Loika, Konstantin G Arbeev, Elena Loiko, Olivia Bagley, Matt Duan, Arseniy Yashkin, Svetlana V Ukraintseva, Mikhail Kovtun, Anatoliy I Yashin, Alexander M Kulminski
Age-related diseases may result from shared biological mechanisms in intrinsic processes of aging. Genetic effects on age-related diseases are often modulated by environmental factors due to their little contribution to fitness or are mediated through certain endophenotypes. Identification of genetic variants with pleiotropic effects on both common complex diseases and endophenotypes may reveal potential conflicting evolutionary pressures and deliver new insights into shared genetic contribution to healthspan and lifespan...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27751919/racial-socioeconomic-and-gender-disparities-in-the-presentation-treatment-and-outcomes-of-adult-chiari-i-malformations
#16
Max O Krucoff, Steven Cook, Owoicho Adogwa, Jessica Moreno, Siyun Yang, Jichun Xie, Alexander O Firempong, Nandan Lad, Carlos A Bagley
OBJECT: To examine the role of race, gender, and socioeconomics on presentations and outcomes of adult Chiari 1 malformations. METHODS: The charts of 638 adult patients with Chiari 1 malformations were reviewed, and 287 patients were included. Race, gender, insurance status, symptoms, depth of cerebellar tonsillar herniation, and presence of syringomyelia were examined as covariates in multivariate logistic regression models to identify independent predictors of presentation and outcome...
October 14, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27749670/atlantoaxial-rotatory-subluxation-a-review-for-the-pediatric-emergency-physician
#17
Merritt D Kinon, Rani Nasser, Jonathan Nakhla, Rupen Desai, Jessica R Moreno, Reza Yassari, Carlos A Bagley
Pediatric emergency physicians must have a high clinical suspicion for atlantoaxial rotatory subluxation (AARS), particularly when a child presents with neck pain and an abnormal head posture without the ability to return to a neutral position. As shown in the neurosurgical literature, timely diagnosis and swift initiation of treatment have a greater chance of treatment success for the patient. However, timely treatment is complicated because torticollis can result from a variety of maladies, including: congenital abnormalities involving the C1-C2 joint or the surrounding supporting muscles and ligaments, central nervous system abnormalities, obstetric palsies from brachial plexus injuries, clavicle fractures, head and neck surgery, and infection...
October 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27695706/community-violence-concerns-and-adolescent-sleep
#18
Erika J Bagley, Kelly M Tu, Joseph A Buckhalt, Mona El-Sheikh
OBJECTIVE: The goal of this study was to examine links between concerns about community violence and objective and subjective sleep parameters in an adolescent sample. Sex was considered as a moderator of effects. DESIGN: The study used a cross-sectional design. PARTICIPANTS: The community-based sample included 252 adolescents (53% girls) with an average age of 15.79 years (SD = 0.81) from the Southeastern United States. The sample included 34% African American and 66% European American adolescents from a wide range of socioeconomic backgrounds...
March 2016: Sleep Health
https://www.readbyqxmd.com/read/27683695/independent-predictors-of-reliability-between-full-time-employee-dependent-acquisition-of-functional-outcomes-compared-to-non-full-time-employee-dependent-methodologies-a-prospective-single-institutional-study
#19
Owoicho Adogwa, Aladine A Elsamadicy, Joseph Cheng, Carlos Bagley
BACKGROUND: The prospective acquisition of reliable patient-reported outcomes (PROs) measures demonstrating the effectiveness of spine surgery, or lack thereof, remains a challenge. The aims of this study are to compare the reliability of functional outcomes metrics obtained using full time employee (FTE) vs. non-FTE-dependent methodologies and to determine the independent predictors of response reliability using non FTE-dependent methodologies. METHODS: One hundred and nineteen adult patients (male: 65, female: 54) undergoing one- and two-level lumbar fusions at Duke University Medical Center were enrolled in this prospective study...
March 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/27683692/comparison-of-surgical-outcomes-after-anterior-cervical-discectomy-and-fusion-does-the-intra-operative-use-of-a-microscope-improve-surgical-outcomes
#20
Owoicho Adogwa, Aladine Elsamadicy, Elizabeth Reiser, Cole Ziegler, Kyle Freischlag, Joseph Cheng, Carlos A Bagley
BACKGROUND: The primary aim of this study was to assess and compare the complications profile as well as long-term clinical outcomes between patients undergoing an Anterior Cervical Discectomy and Fusion (ACDF) procedure with and without the use of an intra-operative microscope. METHODS: One hundred and forty adult patients (non-microscope cohort: 81; microscope cohort: 59) undergoing ACDF at a major academic medical center were included in this study. Enrollment criteria included available demographic, surgical and clinical outcome data...
March 2016: Journal of Spine Surgery (Hong Kong)
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