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https://www.readbyqxmd.com/read/29447625/predicting-help-seeking-behavior-the-impact-of-knowing-someone-close-who-has-sought-help
#1
David J Disabato, Jerome L Short, Diane M Lameira, Karen D Bagley, Stephanie J Wong
OBJECTIVES: This study sought to replicate and extend research on social facilitators of college student's help seeking for psychological problems. PARTICIPANTS: We collected data on 420 ethnically diverse college students at a large public university (September 2008 - May 2010). METHODS: Students completed a cross-sectional online survey. RESULTS: We found that students who were aware of close others' (e.g., family, friends) help seeking were two times more likely to have sought formal (e...
February 15, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29436820/strategy-for-generating-sequence-defined-aptamer-reagent-sets-for-detecting-protein-contaminants-in-biotherapeutics
#2
James B McGivney, Andrew T Csordas, Faye M Walker, Elizabeth R Bagley, Emily M Gruber, Peter L Mage, Jose Casas-Finet, Margaret A Nakamoto, Michael Eisenstein, Christopher J Larkin, Robert J Strouse, H Tom Soh
Biologic drugs are typically manufactured in mammalian host cells, and it is critical from a drug safety and efficacy perspective to detect and remove host cell proteins (HCPs) during production. This is currently achieved with sets of polyclonal antibodies (pAbs), but these suffer from critical shortcomings because their composition is inherently undefined, and they cannot detect nonimmunogenic HCPs. In this work, we report a high-throughput screening and array-based binding characterization strategy that we employed to generate a set of aptamers that overcomes these limitations to achieve sensitive, broad-spectrum detection of HCPs from the widely used Chinese hamster ovary (CHO) cell line...
February 13, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29411444/the-role-of-hybridization-during-ecological-divergence-of-southwestern-white-pine-pinus-strobiformis-and-limber-pine-p-flexilis
#3
Mitra Menon, Justin C Bagley, Christopher J Friedline, Amy V Whipple, Anna W Schoettle, Alejandro Leal-Saenz, Christian Wehenkel, Francisco Molina-Freaner, Lluvia Flores-Renteria, M Socorro Gonzalez-Elizondo, Richard A Sniezko, Samuel A Cushman, Kristen M Waring, Andrew J Eckert
Interactions between extrinsic factors, such as disruptive selection, and intrinsic factors, such as genetic incompatibilities among loci, often contribute towards the maintenance of species boundaries. The relative roles of these factors in the establishment of reproductive isolation can be examined using species pairs characterized by gene flow throughout their divergence history. We investigated the process of speciation and the maintenance of species boundaries between Pinus strobiformis and P. flexilis...
February 7, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29398291/predictors-for-perioperative-blood-transfusion-in-elderly-patients-with-extra-capsular-hip-fractures-treated-with-cephalo-medullary-nailing
#4
M Ali Fazal, Caroline Bagley, Parag Garg
PURPOSE: The aim of our study was to determine predictive factors and requirement for perioperative blood transfusion in elderly patients with extra capsular hip fractures treated with cephalo-medullary device. METHODS: Seventy-nine patients with extra capsular hip fractures treated with cephalo-medullary nailing were included in the study. Age, sex, ASA grade, timing of surgery, preoperative and postoperative haemoglobin, length of hospital stay, fracture type, number of units transfused and 30-day mortality were recorded...
December 8, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29389721/quantitative-assessment-of-knee-progression-angle-during-gait-in-children-with-cerebral-palsy
#5
Jon R Davids, Nina Q Cung, Robin Pomeroy, Brooke Schultz, Leslie Torburn, Vedant A Kulkarni, Sean Brown, Anita M Bagley
BACKGROUND: Abnormal hip rotation is a common deviation in children with cerebral palsy (CP). Clinicians typically assess hip rotation during gait by observing the direction that the patella points relative to the path of walking, which is referred to as the knee progression angle (KPA). Two kinematic methods for calculating the KPA are compared with each other. Video-based qualitative assessment of KPA is compared with the quantitative methods to determine reliability and validity. METHODS: The KPA was calculated by both direct and indirect methods for 32 typically developing (TD) children and a convenience cohort of 43 children with hemiplegic type CP...
January 31, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29383376/are-medicaid-work-requirements-legal
#6
Nicholas Bagley
No abstract text is available yet for this article.
January 30, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29362786/characteristics-of-interim-publications-of-randomized-clinical-trials-and-comparison-with-final-publications
#7
COMPARATIVE STUDY
Steven Woloshin, Lisa M Schwartz, Pamela J Bagley, Heather B Blunt, Brian White
No abstract text is available yet for this article.
January 23, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29357518/fiber-type-specific-analysis-of-ampk-isoforms-in-human-skeletal-muscle-advancement-in-methods-via-capillary-nano-immunoassay
#8
Irene S Tobias, Kara K Lazauskas, Jose A Arevalo, James Robert Bagley, Lee E Brown, Andrew J Galpin
Human skeletal muscle is a heterogeneous mixture of multiple fiber types (FT). Unfortunately, current methods for FT-specific study are constrained by limits of protein detection in single muscle fiber samples. These limitations beget compensatory resource-intensive procedures, ultimately dissuading FT-specific research. Additionally, previous studies neglected hybrid FT, confining their analyses to only pure FT. Here we present novel methods of protein detection across a wider spectrum of human skeletal muscle FT using fully automated capillary nano-immunoassay (CNIA) technology...
December 14, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29355811/preoperative-hemoglobin-level-is-associated-with-increased-healthcare-utilization-after-elective-spinal-fusion-%C3%A2-3-levels-in-elderly-male-spine-deformity-patients
#9
Aladine A Elsamadicy, Owoicho Adogwa, Michael Ongele, Amanda R Sergesketter, Aaron Tarnasky, David E T Lubkin, Nicolas Drysdale, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: Measures of healthcare utilization such as length of hospital stay (LOS) are used as proxies for quality of care after spine surgery. Accordingly, hospitals and health systems are investing considerable resources into the pre-operative identification of patients at risk for prolonged LOS. This study aims to investigate the impact of preoperative hemoglobin on outcomes and LOS after spinal fusion. METHODS: The medical records of 204 elderly (≥60 years) male patients undergoing elective spinal fusion (≥3 levels) at a major academic institution from 2005 to 2015 were reviewed...
January 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29354739/posterolateral-thoracic-decompression-with-anterior-column-cage-reconstruction-versus-decompression-alone-for-spinal-metastases-with-cord-compression-analysis-of-perioperative-complications-and-outcomes
#10
Aladine A Elsamadicy, Owoicho Adogwa, Amanda Sergesketter, Emily Lydon, Carlos A Bagley, Isaac O Karikari
Background: The optimal surgical strategy for patients with spinal metastases remains unknown. The aim of this study was to determine if performing an anterior column reconstruction to a posterolateral approach adds to perioperative complications. Methods: A retrospective review of all adult patients with spinal metastases who had a posterolateral approach for resection between January 2000 and December 2008. Perioperative complications and functional outcomes were determined...
December 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29317368/interdisciplinary-care-model-independently-decreases-use-of-critical-care-services-after-corrective-surgery-for-adult-degenerative-scoliosis
#11
Owoicho Adogwa, Aladine A Elsamadicy, Amanda R Sergesketter, Michael Ongele, Victoria Vuong, Syed Khalid, Jessica Moreno, Joseph Cheng, Isaac O Karikari, Carlos A Bagley
OBJECTIVE: Interdisciplinary management of elderly patients requiring spine surgery has been shown to improve short and long-term outcomes. The aim of this study is to determine whether an interdisciplinary team approach mitigates use of intensive care unit (ICU) resources. METHODS: A unique co-management model for elderly patients undergoing lumbar fusion surgery was implemented at a major academic medical center. The Peri-operative Optimization of Senior Health Program(POSH) was launched with the aim of improving outcomes in elderly patients(>65-years-old) undergoing complex lumbar spine surgery...
January 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29298320/ensemble-method-for-dengue-prediction
#12
Anna L Buczak, Benjamin Baugher, Linda J Moniz, Thomas Bagley, Steven M Babin, Erhan Guven
BACKGROUND: In the 2015 NOAA Dengue Challenge, participants made three dengue target predictions for two locations (Iquitos, Peru, and San Juan, Puerto Rico) during four dengue seasons: 1) peak height (i.e., maximum weekly number of cases during a transmission season; 2) peak week (i.e., week in which the maximum weekly number of cases occurred); and 3) total number of cases reported during a transmission season. A dengue transmission season is the 12-month period commencing with the location-specific, historical week with the lowest number of cases...
2018: PloS One
https://www.readbyqxmd.com/read/29247432/antimicrobial-photodynamic-therapy-a-promising-treatment-for-prosthetic-joint-infections
#13
Timothy Briggs, Gordon Blunn, Simon Hislop, Rita Ramalhete, Caroline Bagley, David McKenna, Melanie Coathup
Periprosthetic joint infection (PJI) is associated with high patient morbidity and a large financial cost. This study investigated Photodynamic Therapy (PDT) as a means of eradicating bacteria that cause PJI, using a laser with a 665-nm wavelength and methylene blue (MB) as the photosensitizer. The effectiveness of MB concentration on the growth inhibition of methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Pseudomonas aeruginosa and Acinetobacter baumannii was investigated...
December 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29238642/effect-of-social-support-and-marital-status-on-perceived-surgical-effectiveness-and-30-day-hospital-readmission
#14
Owoicho Adogwa, Aladine A Elsamadicy, Victoria D Vuong, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
Study Design: Retrospective cohort review. Objective: To determine whether higher levels of social support are associated with improved surgical outcomes after elective spine surgery. Methods: The medical records of 430 patients (married, n = 313; divorced/separated/widowed, n = 71; single, n = 46) undergoing elective spine surgery at a major academic medical center were reviewed. Patients were categorized by their marital status at the time of surgery...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29225135/adult-spinal-ependymomas-an-epidemiological-study
#15
Syed I Khalid, Ryan Kelly, Owoicho Adogwa, Ankit Metha, Carlos Bagley, Joseph Cheng, John O'Toole
OBJECTIVE: In adults, spinal ependymomas constitute only 3-6% of central nervous system tumors. Due to their rarity and poor prognosis, large population-based studies are needed to assess the epidemiology and survival risk factors associated with these tumors in the hope of improving outcome. The authors undertook this retrospective study to explore factors that may influence survival in adult patients with spinal ependymomas. METHODS: Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, a prospective cancer registry, the authors retrospectively assessed survival in histologically confirmed spinal ependymomas in patients 18 years of age and older...
December 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29223680/dysregulation-of-c-x-c-motif-ligand-10-during-aging-and-association-with-cognitive-performance
#16
Steven Bradburn, Jamie McPhee, Liam Bagley, Michael Carroll, Mark Slevin, Nasser Al-Shanti, Yoann Barnouin, Jean-Yves Hogrel, Mati Pääsuke, Helena Gapeyeva, Andrea Maier, Sarianna Sipilä, Marco Narici, Andrew Robinson, David Mann, Antony Payton, Neil Pendleton, Gillian Butler-Browne, Chris Murgatroyd
Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand 10 (CXCL10) was found to be higher in older adults, compared with young, and negatively associated with working memory performance. This coincided with an age-related reduction in blood DNA methylation at specific CpGs within the CXCL10 gene promoter...
November 23, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29165642/the-corticospinal-reserve-capacity-reorganization-of-motor-area-and-excitability-as-a-novel-pathophysiological-concept-in-cervical-myelopathy
#17
Anna Zdunczyk, Vera Schwarzer, Michael Mikhailov, Brendon Bagley, Tizian Rosenstock, Thomas Picht, Peter Vajkoczy
BACKGROUND: In degenerative cervical myelopathy (DCM), the dynamics of disease progression and the outcome after surgical decompression vary interindividually and do not necessarily correlate with radiological findings. OBJECTIVE: To improve diagnostic power in DCM by better characterization of the underlying pathophysiology using navigated transcranial magnetic stimulation (nTMS). METHODS: Eighteen patients with DCM due to cervical spinal canal stenosis were examined preoperatively with nTMS...
November 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29125432/association-between-baseline-cognitive-impairment-and-postoperative-delirium-in-elderly-patients-undergoing-surgery-for-adult-spinal-deformity
#18
Owoicho Adogwa, Aladine A Elsamadicy, Victoria D Vuong, Jared Fialkoff, Joseph Cheng, Isaac O Karikari, Carlos A Bagley
OBJECTIVE Postoperative delirium is common in elderly patients undergoing spine surgery and is associated with a longer and more costly hospital course, functional decline, postoperative institutionalization, and higher likelihood of death within 6 months of discharge. Preoperative cognitive impairment may be a risk factor for the development of postoperative delirium. The aim of this study was to investigate the relationship between baseline cognitive impairment and postoperative delirium in geriatric patients undergoing surgery for degenerative scoliosis...
November 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29114742/scientific-trials-in-the-laboratories-not-the-courts
#19
Nicolas Bagley, Aaron E Carroll, Pieter A Cohen
No abstract text is available yet for this article.
November 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29109065/the-impact-of-chronic-kidney-disease-on-postoperative-outcomes-in-patients-undergoing-lumbar-decompression-and-fusion
#20
Owoicho Adogwa, Aladine A Elsamadicy, Amanda Sergesketter, Deborah Oyeyemi, Diego Galan, Victoria D Vuong, Syed Khalid, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
OBJECTIVE: To determine whether preoperative chronic kidney disease (CKD) is associated with inferior perioperative outcomes in patients undergoing lumbar arthrodesis. METHODS: Medical records of 293 adult (≥18 years old) patients with spine deformity undergoing elective lumbar spine decompression and fusion at a major academic institution from 2006 to 2015 were reviewed. We identified 18 (6.1%) patients with a clinical diagnosis of CKD (CKD group, n = 18; no-CKD group, n = 275)...
November 3, 2017: World Neurosurgery
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