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https://www.readbyqxmd.com/read/29165642/the-corticospinal-reserve-capacity-reorganization-of-motor-area-and-excitability-as-a-novel-pathophysiological-concept-in-cervical-myelopathy
#1
Anna Zdunczyk, Vera Schwarzer, Michael Mikhailov, Brendon Bagley, Tizian Rosenstock, Thomas Picht, Peter Vajkoczy
BACKGROUND: In degenerative cervical myelopathy (DCM), the dynamics of disease progression and the outcome after surgical decompression vary interindividually and do not necessarily correlate with radiological findings. OBJECTIVE: To improve diagnostic power in DCM by better characterization of the underlying pathophysiology using navigated transcranial magnetic stimulation (nTMS). METHODS: Eighteen patients with DCM due to cervical spinal canal stenosis were examined preoperatively with nTMS...
November 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29125432/association-between-baseline-cognitive-impairment-and-postoperative-delirium-in-elderly-patients-undergoing-surgery-for-adult-spinal-deformity
#2
Owoicho Adogwa, Aladine A Elsamadicy, Victoria D Vuong, Jared Fialkoff, Joseph Cheng, Isaac O Karikari, Carlos A Bagley
OBJECTIVE Postoperative delirium is common in elderly patients undergoing spine surgery and is associated with a longer and more costly hospital course, functional decline, postoperative institutionalization, and higher likelihood of death within 6 months of discharge. Preoperative cognitive impairment may be a risk factor for the development of postoperative delirium. The aim of this study was to investigate the relationship between baseline cognitive impairment and postoperative delirium in geriatric patients undergoing surgery for degenerative scoliosis...
November 10, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29114742/scientific-trials-in-the-laboratories-not-the-courts
#3
Nicolas Bagley, Aaron E Carroll, Pieter A Cohen
No abstract text is available yet for this article.
November 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29109065/the-impact-of-chronic-kidney-disease-on-post-operative-outcomes-in-patients-undergoing-lumbar-decompression-and-fusion
#4
Owoicho Adogwa, Aladine A Elsamadicy, Amanda Sergesketter, Deborah Oyeyemi, Diego Galan, Victoria D Vuong, Syed Khalid, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: Little is known of the impact of pre-operative chronic kidney disease (CKD) on post-operative complications in patients undergoing lumbar arthrodesis. The aim of this study is to determine whether pre-operative CKD is associated with inferior peri-operative outcomes. METHODS: The medical records of 293 adult (≥18 years-old) spine deformity patients undergoing elective lumbar spine decompression and fusion at a major academic institution from 2006 to 2015 were reviewed...
November 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29083203/brief-optogenetic-inhibition-of-rat-lateral-or-ventrolateral-periaqueductal-gray-augments-the-acquisition-of-pavlovian-fear-conditioning
#5
Neda Assareh, Elena E Bagley, Pascal Carrive, Gavan P McNally
The midbrain periaqueductal gray (PAG) coordinates the expression and topography of defensive behaviors to threat and also plays an important role in Pavlovian fear learning itself. Whereas the role of PAG in the expression of defensive behavior is well understood, the relationship between the activity of PAG neurons and fear learning, the exact timing of PAG contributions to learning during the conditioning trial, and the contributions of different PAG columns to fear learning are poorly understood. We assessed the effects of optogenetic inhibition of lateral (LPAG) and ventrolateral PAG (VLPAG) neurons on fear learning...
October 30, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29081391/independent-association-between-pre-operative-cognitive-status-and-discharge-location-after-surgery-a-strategy-to-reduce-resource-use-after-surgery-for-deformity
#6
Owoicho Adogwa, Aladine A Elsamadicy, Amanda Sergesketter, Victoria D Vuong, Jessica Moreno, Joseph Cheng, Isaac O Karikari, Carlos A Bagley
BACKGROUND: The aim of this study is to determine if preoperative scores on a screening measure for cognitive status(the Saint Louis Mental Status), were associated with discharge to a location other than home in elderly patients undergoing surgery for deformity. METHODS: Elderly subjects (≥65 years) undergoing a planned elective spinal surgery for correction of adult degenerative scoliosis were enrolled in this study. Pre-operative baseline cognition was assessed using the validated Saint Louis Mental Status (SLUMS) test...
October 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29069593/phospholipid-homeostasis-regulates-dendrite-morphogenesis-in-drosophila-sensory-neurons
#7
Shan Meltzer, Joshua A Bagley, Gerardo Lopez Perez, Caitlin E O'Brien, Laura DeVault, Yanmeng Guo, Lily Yeh Jan, Yuh-Nung Jan
Disruptions in lipid homeostasis have been observed in many neurodevelopmental disorders that are associated with dendrite morphogenesis defects. However, the molecular mechanisms of how lipid homeostasis affects dendrite morphogenesis are unclear. We find that easily shocked (eas), which encodes a kinase with a critical role in phospholipid phosphatidylethanolamine (PE) synthesis, and two other enzymes in this synthesis pathway are required cell autonomously in sensory neurons for dendrite growth and stability...
October 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/29057350/impact-of-alcohol-use-on-30-day-complication-and-readmission-rates-after-elective-spinal-fusion-%C3%A2-2-levels-for-adult-spine-deformity-a-single-institutional-study-of-1-010-patients
#8
Aladine A Elsamadicy, Owoicho Adogwa, Victoria D Vuong, Amanda Sergesketter, Gireesh Reddy, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: Alcohol use has been shown to affect surgical outcomes. However, it is unknown what effect alcohol use has on postoperative complications or readmission rates in spinal fusion surgery. The aim of this study is to determine the impact of preoperative alcohol use on 30-day readmission rates or the complications profile after adult elective spinal fusion for deformity correction (≥2 levels). METHODS: The medical records of 1,010 adult patients undergoing elective spinal fusion (≥2 levels) for spinal deformities at a major academic institution from 2005 to 2015 were reviewed...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29057343/the-prevalence-of-undiagnosed-pre-surgical-cognitive-impairment-and-its-post-surgical-clinical-impact-in-elderly-patients-undergoing-surgery-for-adult-spinal-deformity
#9
Owoicho Adogwa, Aladine A Elsamadicy, Emily Lydon, Victoria D Vuong, Joseph Cheng, Isaac O Karikari, Carlos A Bagley
BACKGROUND: Pre-existing cognitive impairment (CI) is emerging as a predictor of poor post-operative outcomes in elderly patients. Little is known about impaired preoperative cognition and outcomes after elective spine surgery in this patient population. The purpose of this study was to assess the prevalence of neuro CI in elderly patients undergoing deformity surgery and its impact on postoperative outcomes. METHODS: Elderly subjects undergoing elective spinal surgery for correction of adult degenerative scoliosis were enrolled in this study...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29056351/estradiol-increases-choice-of-cocaine-over-food-in-male-rats
#10
Jared R Bagley, Julia Adams, Rachel V Bozadjian, Lana Bubalo, Kyle L Ploense, Tod E Kippin
Estradiol modulates the rewarding and reinforcing properties of cocaine in females, including an increase in selection of cocaine over alternative reinforcers. However, the effects of estradiol on male cocaine self-administration behavior are less studied despite equivalent levels of estradiol in the brains of adult males and females, estradiol effects on motivated behaviors in males that share underlying neural substrates with cocaine reinforcement as well as expression of estrogen receptors in the male brain...
October 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29031030/ectopic-bone-as-a-nidus-for-calcium-oxalate-urocystolithiasis-in-a-cat
#11
J P Lulich, H S Prasad, M Manno, B Bagley
A 7-year-old female spayed domestic shorthair cat was referred to the urology service for nonsurgical urocystolith removal. A urolith was attached to the urothelium by ectopic bone. Interventional removal without surgery was successful. Follow-up evaluation 3 years after urolith removal revealed recurrent uroliths, bladder wall mineralization, and marked renal mineralization. This case illustrates the metaplastic potential of the urothelium and that ectopic bone should be included among the pathological factors that promote lithogenesis...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28973659/perfluorooctane-sulfonate-induced-hepatic-steatosis-in-male-sprague-dawley-rats-is-not-attenuated-by-dietary-choline-supplementation
#12
Bradford D Bagley, Shu-Ching Chang, David J Ehresman, Alan Eveland, Jeremiah Zitzow, George A Parker, Jeffrey M Peters, Kendall B Wallace, John L Butenhoff
Perfluorooctane sulfonate (PFOS) is an environmentally persistent chemical. Dietary 100 ppm PFOS fed to male mice and rats for four weeks caused hepatic steatosis through an unknown mechanism. Choline deficient diets can cause hepatic steatosis. A hepatic choline:PFOS ion complex was hypothesized to cause this effect in mice. This study tested whether dietary choline supplementation attenuates PFOS-induced hepatic steatosis in rats. Sprague Dawley rats (12/sex/group) were fed control, choline supplemented (CS), 100 ppm PFOS, or 100 ppm PFOS + CS diets for three weeks...
August 30, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28972020/innovative-contracting-for-pharmaceuticals-and-medicaid-s-best-price-rule
#13
Rachel Sachs, Nicholas Bagley, Darius N Lakdawalla
In recent years, drug manufacturers and private payers have expressed interest in novel pricing models that more closely link a drug's price to its value. Indication-based pricing, outcome-based pricing, drug licenses, and drug mortgages have all been discussed as alternatives to paying strictly for volume. Manufacturers and payers have complained, however, that Medicaid's "best-price rule" inhibits their ability to enter into these new pricing arrangements. This article examines the best-price rule and assesses to what extent, if any, it might frustrate the goal of paying for value...
September 28, 2017: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/28964830/causal-effects-of-cardiovascular-risk-factors-on-onset-of-major-age-related-diseases-a-time-to-event-mendelian-randomization-study
#14
Liang He, Irina Culminskaya, Yury Loika, Konstantin G Arbeev, Olivia Bagley, Matt Duan, Anatoliy I Yashin, Alexander M Kulminski
BACKGROUNDS: Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures. METHODS: We conducted two-stage time-to-event Mendelian randomization meta-analyses combining five large-scale longitudinal cohorts to investigate dynamic causal effects of cardiovascular disease risk factors including body mass index (BMI), systolic blood pressure (SBP), and lipids on the age-at-onset of age-related diseases...
September 28, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28960161/geriatric-comanagement-reduces-perioperative-complications-and-shortens-duration-of-hospital-stay-after-lumbar-spine-surgery-a-prospective-single-institution-experience
#15
Owoicho Adogwa, Aladine A Elsamadicy, Victoria D Vuong, Jessica Moreno, Joseph Cheng, Isaac O Karikari, Carlos A Bagley
OBJECTIVE Geriatric patients undergoing lumbar spine surgery have unique needs due to the physiological changes of aging. They are at risk for adverse outcomes such as delirium, infection, and iatrogenic complications, and these complications, in turn, contribute to the risk of functional decline, nursing home admission, and death. Whether preoperative and perioperative comanagement by a geriatrician reduces the incidence of in-hospital complications and length of in-hospital stay after elective lumbar spine surgery remains unknown...
September 29, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28952977/to-improve-substance-use-disorder-prevention-treatment-and-recovery-engage-the-family
#16
Alicia S Ventura, Sarah M Bagley
: Approximately 21 million people in the United States have a substance use disorder (SUD); the number of family members impacted by a loved one's SUD is exponentially greater. Affected family members of individuals with SUDs are at high risk for developing chronic medical and psychiatric health conditions, are high utilizers of the health care system, and have high health care expenditures. Family members play a central role in the lives of many individuals with SUDs; information given to family members can have a significant impact on persons with addiction and therefore the SUD treatment that an individual might receive...
August 4, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28939359/streptococcus-suis-meningitis-can-require-a-prolonged-treatment-course
#17
Jean Dejace, Patrick Bagley, Emily Wood
We report a case of recrudescent Streptococcus suis meningitis requiring a prolonged treatment course. A few similar cases can be found in the burgeoning literature on what remains a relatively uncommon disease in humans, and these patients should be monitored carefully upon completion of therapy.
September 20, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28902101/early-ambulation-decreases-length-of-hospital-stay-perioperative-complications-and-improves-functional-outcomes-in-elderly-patients-undergoing-surgery-for-correction-of-adult-degenerative-scoliosis
#18
Owoicho Adogwa, Aladine A Elsamadicy, Jared Fialkoff, Joseph Cheng, Isaac O Karikari, Carlos Bagley
STUDY DESIGN: Ambispective cohort review. OBJECTIVE: To examine the effects of early mobilization on patient outcomes, complications profile, and 30-day readmission rates. SUMMARY OF BACKGROUND DATA: Prolonged immobilization after surgery can result in functional decline and an increased risk of hospital-associated complications. METHODS: We conducted an ambispective study of 125 elderly patients (>65 years) undergoing elective spinal surgery for correction of adult degenerative scoliosis...
September 15, 2017: Spine
https://www.readbyqxmd.com/read/28901218/four-week-dietary-supplementation-with-10-and-or-15-fold-basal-choline-caused-decreased-body-weight-in-sprague-dawley-rats
#19
Bradford D Bagley, Shu-Ching Chang, David J Ehresman, Alan Eveland, George A Parker, Jeffrey M Peters, John L Butenhoff
Choline is an essential nutrient utilized for phosphatidylcholine biosynthesis and lipoprotein packaging and secretion. Recently, choline supplementation has been used by athletes and the public for weight loss. However, the potential toxicological impact of choline dietary supplementation requires further investigation. This study examined the effects of choline dietary supplementation in Sprague Dawley rats for 4 weeks. Rats were fed diets containing basal choline levels (control) or 5-, 10-, or 15-fold (5×, 10×, or 15×) basal diet concentration...
October 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28900588/correction-hydration-status-as-a-predictor-of-high-altitude-mountaineering-performance
#20
Eric Ladd, Katherine M Shea, Patrick Bagley, Paul S Auerbach, Elizabeth A Pirrotta, Ewen Wang, Grant Lipman
[This corrects the article DOI: 10.7759/cureus.918.].
September 8, 2017: Curēus
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