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https://www.readbyqxmd.com/read/28618076/priorities-for-methodological-research-on-patient-and-public-involvement-in-clinical-trials-a-modified-delphi-process
#1
Anna Kearney, Paula Williamson, Bridget Young, Heather Bagley, Carrol Gamble, Simon Denegri, Delia Muir, Natalie A Simon, Stephen Thomas, Jim T Elliot, Helen Bulbeck, Joanna C Crocker, Claire Planner, Claire Vale, Mike Clarke, Tim Sprosen, Kerry Woolfall
BACKGROUND: Despite increasing international interest, there is a lack of evidence about the most efficient, effective and acceptable ways to implement patient and public involvement (PPI) in clinical trials. OBJECTIVE: To identify the priorities of UK PPI stakeholders for methodological research to help resolve uncertainties about PPI in clinical trials. DESIGN: A modified Delphi process including a two round online survey and a stakeholder consensus meeting...
June 15, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28585053/circulating-levels-of-dickkopf-1-osteoprotegerin-and-sclerostin-are-higher-in-old-compared-with-young-men-and-women-and-positively-associated-with-whole-body-bone-mineral-density-in-older-adults
#2
J Coulson, L Bagley, Y Barnouin, S Bradburn, G Butler-Browne, H Gapeyeva, J-Y Hogrel, T Maden-Wilkinson, A B Maier, C Meskers, C Murgatroyd, M Narici, M Pääsuke, L Sassano, S Sipilä, N Al-Shanti, L Stenroth, D A Jones, J S McPhee
Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young. INTRODUCTION: This study aims to investigate the relationship between whole-body bone mineral density (WBMD) and levels of circulating factors with known roles in bone remodelling during 'healthy' ageing...
June 5, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28574333/depression-as-an-independent-predictor-of-postoperative-delirium-in-spine-deformity-patients-undergoing-elective-spine-surgery
#3
Aladine A Elsamadicy, Owoicho Adogwa, Emily Lydon, Amanda Sergesketter, Rayan Kaakati, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
OBJECTIVE Depression is the most prevalent affective disorder in the US, and patients with spinal deformity are at increased risk. Postoperative delirium has been associated with inferior surgical outcomes, including morbidity and mortality. The relationship between depression and postoperative delirium in patients undergoing spine surgery is relatively unknown. The aim of this study was to determine if depression is an independent risk factor for the development of postoperative delirium in patients undergoing decompression and fusion for deformity...
June 2, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28573751/early-weaning-stress-induces-chronic-functional-diarrhea-intestinal-barrier-defects-and-increased-mast-cell-activity-in-a-porcine-model-of-early-life-adversity
#4
C S Pohl, J E Medland, E Mackey, L L Edwards, K D Bagley, M P DeWilde, K J Williams, A J Moeser
BACKGROUND: Early life adversity (ELA) is a risk factor for development of gastrointestinal disorders later in life. The underlying mechanisms through which ELA and sex interact to influence disease susceptibility remains poorly understood. METHODS: Utilizing a porcine early weaning stress (EWS) model to mimic ELA, we investigated the long-term effects of EWS on functional diarrhea, ileal permeability, mast cell activity and mast cell relationship with enteric ganglia...
June 1, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28553066/usefulness-of-the-crafft-to-diagnose-alcohol-or-cannabis-use-disorders-in-a-sample-of-emerging-adults-with-past-month-alcohol-or-cannabis-use
#5
Sarah M Bagley, Bradley J Anderson, Michael D Stein
No abstract text is available yet for this article.
2017: Journal of Child & Adolescent Substance Abuse
https://www.readbyqxmd.com/read/28549411/fluorender-joint-freehand-segmentation-and-visualization-for-many-channel-fluorescence-data-analysis
#6
Yong Wan, Hideo Otsuna, Holly A Holman, Brig Bagley, Masayoshi Ito, A Kelsey Lewis, Mary Colasanto, Gabrielle Kardon, Kei Ito, Charles Hansen
BACKGROUND: Image segmentation and registration techniques have enabled biologists to place large amounts of volume data from fluorescence microscopy, morphed three-dimensionally, onto a common spatial frame. Existing tools built on volume visualization pipelines for single channel or red-green-blue (RGB) channels have become inadequate for the new challenges of fluorescence microscopy. For a three-dimensional atlas of the insect nervous system, hundreds of volume channels are rendered simultaneously, whereas fluorescence intensity values from each channel need to be preserved for versatile adjustment and analysis...
May 26, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28541854/the-feasibility-and-time-required-for-routine-health-literacy-assessment-in-surgical-practice-and-effect-on-patient-satisfaction
#7
Ryan D Eubanks, Jesse N Nodora, Chiu-Hsieh Hsu, Marian Bagley, Marcia E Bouton, Maria Elena Martinez, Ian K Komenaka
Patients with limited health literacy (HL) have higher likelihood of problems with communication and may decrease patient satisfaction. This study was performed to determine the time required for routine HL assessment and its effect on patient satisfaction. Retrospective review over four years of consecutive patients who attended a breast clinic who underwent HL assessment as part of routine care. A total of 3126 consecutive patients from 2010 to 2014. Of the 3126 patients (96.9%), 3030 of were capable of undergoing HL assessment...
May 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28531553/hiv-1-viral-load-measurement-in-venous-blood-and-fingerprick-blood-using-abbott-realtime-hiv-1-dbs-assay
#8
Ning Tang, Vihanga Pahalawatta, Andrea Frank, Zowie Bagley, Raquel Viana, John Lampinen, Gregor Leckie, Shihai Huang, Klara Abravaya, Carole L Wallis
BACKGROUND: HIV RNA suppression is a key indicator for monitoring success of antiretroviral therapy. From a logistical perspective, viral load (VL) testing using Dried Blood Spots (DBS) is a promising alternative to plasma based VL testing in resource-limited settings. OBJECTIVES: To evaluate the analytical and clinical performance of the Abbott RealTime HIV-1 assay using a fully automated one-spot DBS sample protocol. STUDY DESIGN: Limit of detection (LOD), linearity, lower limit of quantitation (LLQ), upper limit of quantitation (ULQ), and precision were determined using serial dilutions of HIV-1 Virology Quality Assurance stock (VQA Rush University), or HIV-1-containing armored RNA, made in venous blood...
May 13, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28504681/fused-cerebral-organoids-model-interactions-between-brain-regions
#9
Joshua A Bagley, Daniel Reumann, Shan Bian, Julie Lévi-Strauss, Juergen A Knoblich
Human brain development involves complex interactions between different regions, including long-distance neuronal migration or formation of major axonal tracts. Different brain regions can be cultured in vitro within 3D cerebral organoids, but the random arrangement of regional identities limits the reliable analysis of complex phenotypes. Here, we describe a coculture method combining brain regions of choice within one organoid tissue. By fusing organoids of dorsal and ventral forebrain identities, we generate a dorsal-ventral axis...
May 10, 2017: Nature Methods
https://www.readbyqxmd.com/read/28481225/impact-of-environmental-factors-on-alloimmunity-and-transplant-fate
#10
Leonardo V Riella, Jessamyn Bagley, John Iacomini, Maria-Luisa Alegre
Although gene-environment interactions have been investigated for many years to understand people's susceptibility to autoimmune diseases or cancer, a role for environmental factors in modulating alloimmune responses and transplant outcomes is only now beginning to emerge. New data suggest that diet, hyperlipidemia, pollutants, commensal microbes, and pathogenic infections can all affect T cell activation, differentiation, and the kinetics of graft rejection. These observations reveal opportunities for novel therapeutic interventions to improve graft outcomes as well as for noninvasive biomarker discovery to predict or diagnose graft deterioration before it becomes irreversible...
May 8, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28451264/one-pot-palladium-catalyzed-synthesis-of-sulfonyl-fluorides-from-aryl-bromides
#11
Alyn T Davies, John M Curto, Scott W Bagley, Michael C Willis
A mild, efficient synthesis of sulfonyl fluorides from aryl and heteroaryl bromides utilizing palladium catalysis is described. The process involves the initial palladium-catalyzed sulfonylation of aryl bromides using DABSO as an SO2 source, followed by in situ treatment of the resultant sulfinate with the electrophilic fluorine source NFSI. This sequence represents the first general method for the sulfonylation of aryl bromides, and offers a practical, one-pot alternative to previously described syntheses of sulfonyl fluorides, allowing rapid access to these biologically important molecules...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28435917/effect-of-employment-status-on-length-of-hospital-stay-30-day-readmission-and-patient-reported-outcomes-after-spine-surgery
#12
Owoicho Adogwa, Aladine A Elsamadicy, Jared Fialkoff, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Isaac O Karikari, Carlos A Bagley
BACKGROUND: Growing scrutiny has placed hospitals at the center of readmission prevention. The relationship between pre-operative employment status, length of hospital stays (LOS) and 30-day readmission rates after elective spine surgery remains unclear. METHODS: The medical records of 360 patients (employed: n=174, unemployed: n=70, retired: n=40, disabled: n=76) undergoing elective spine surgery at a major academic medical center were reviewed. Patient demographics, comorbidities, and post-operative complication rates were recorded...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28435915/impact-of-surgical-approach-on-complication-rates-after-elective-spinal-fusion-%C3%A2-3-levels-for-adult-spine-deformity
#13
Aladine A Elsamadicy, Owoicho Adogwa, Shay Behrens, Amanda Sergesketter, Angel Chen, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: While there are variations in techniques and surgical approaches to spinal fusion, there is not a defined consensus on a recommended surgical approach. The aim of this study is to determine if there was a difference in intra- and post-operative complication rates between different surgical approaches after elective spinal fusion (≥3 levels) for adult spine deformity. METHODS: The medical records of 443 adult spine deformity patients undergoing elective spinal fusion (≥3) at a major academic institution from 2005 to 2015 were reviewed...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28429378/expanding-access-to-naloxone-for-family-members-the-massachusetts-experience
#14
Sarah M Bagley, Leah S Forman, Sarah Ruiz, Kevin Cranston, Alexander Y Walley
INTRODUCTION AND AIMS: The Massachusetts Department of Public Health Overdose Education and Naloxone Distribution Program provides overdose education and naloxone rescue kits to people at risk for overdose and bystanders, including family members. Using Massachusetts Department of Public Health data, the aims are to: (i) describe characteristics of family members who receive naloxone; (ii) identify where family members obtain naloxone; and (iii) describe characteristics of rescues by family members...
April 20, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28415920/what-can-the-food-and-drink-industry-do-to-help-achieve-the-5-free-sugars-goal
#15
Sigrid Gibson, Margaret Ashwell, Jenny Arthur, Lindsey Bagley, Alison Lennox, Peter J Rogers, Sara Stanner
AIMS: To contribute evidence and make recommendations to assist in achieving free sugars reduction, with due consideration to the broader picture of weight management and dietary quality. METHODS: An expert workshop in July 2016 addressed options outlined in the Public Health England report 'Sugar reduction: The evidence for action' that related directly to the food industry. Panel members contributed expertise in food technology, public heath nutrition, marketing, communications, psychology and behaviour...
April 1, 2017: Perspectives in Public Health
https://www.readbyqxmd.com/read/28399547/early-ambulation-decreases-length-of-hospital-stay-peri-operative-complications-and-improves-functional-outcomes-in-elderly-patients-undergoing-surgery-for-correction-of-adult-degenerative-scoliosis
#16
Owoicho Adogwa, Aladine A Elsamadicy, Jared Fialkoff, Joseph Cheng, Isaac O Karikari, Carlos Bagley
STUDY DESIGN: Ambispective cohort review. OBJECTIVE: To examine the effects of early mobilization on patient outcomes, complications profile and 30-day readmission rates. SUMMARY OF BACKGROUND DATA: Prolonged immobilization after surgery can result in functional decline and an increased risk of hospital-associated complications. METHODS: We conducted an ambispective study of 125 elderly patients (> 65 years old) undergoing elective spinal surgery for correction of adult degenerative scoliosis...
April 10, 2017: Spine
https://www.readbyqxmd.com/read/28399073/association-of-intraoperative-blood-transfusions-on-postoperative-complications-30-day-readmission-rates-and-1-year-patient-reported-outcomes
#17
Aladine A Elsamadicy, Owoicho Adogwa, Victoria D Vuong, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
STUDY DESIGN: Ambispective cohort review. OBJECTIVE: The aim of this study was to determine the effect of allogeneic red blood cell (RBC) transfusion on postoperative patient complications profiles and 30-day readmission rates following elective spine surgery. SUMMARY OF BACKGROUND DATA: Thirty-day hospital readmission rates are being used as a proxy for quality of care. Intra- or perioperative allogeneic RBC transfusions are associated with deleterious effects...
April 15, 2017: Spine
https://www.readbyqxmd.com/read/28380563/a-novel-approach-to-estimating-nitrous-oxide-emissions-during-wetting-events-from-single-timepoint-flux-measurements
#18
Brian W Davis, Brian A Needelman, Michel A Cavigelli, Stephanie A Yarwood, Jude E Maul, Gwendolyn A Bagley, Steven B Mirsky
Precipitation and irrigation induce pulses of NO emissions in agricultural soils, but the magnitude, duration, and timing of these pulses remain uncertain. This uncertainty makes it difficult to accurately extrapolate emissions from unmeasured time periods between chamber sampling events. Therefore, we developed a modeling protocol to predict NO emissions from data collected daily for 7 d after wetting events. Within a cover crop-based corn ( L.) production system in Beltsville, MD, we conducted the 7-d time series during four time periods representing a range of corn growth stages in 2013 and 2014...
March 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28359921/increased-30-day-complication-rates-associated-with-laminectomy-in-874-adult-patients-with-spinal-deformity-undergoing-elective-spinal-fusion-a-single-institutional-study
#19
Aladine A Elsamadicy, Owoicho Adogwa, Hunter Warwick, Amanda Sergesketter, Emily Lydon, Ronnie L Shammas, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
OBJECTIVE: Recent studies have reported that decompression with fusion leads to superior outcomes in correction of spinal deformity. The aim of this study was to determine if there is a difference in intraoperative and 30-day postoperative complication rates in patients undergoing spinal fusion with and without decompression. METHODS: Medical records of 874 adult (≥18 years old) patients with spinal deformity undergoing elective spinal fusion at a major academic institution from 2005 to 2015 were reviewed; 374 (42...
June 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28350632/30-day-readmission-after-spine-surgery-an-analysis-of-1400-consecutive-spine-surgery-patients
#20
Owoicho Adogwa, Aladine A Elsamadicy, Jing L Han, Isaac O Karikari, Joseph Cheng, Carlos A Bagley
STUDY DESIGN: Retrospective cohort review. OBJECTIVE: To identify the rates, causes, and risk factors for 30-day unplanned readmissions in after elective spine surgery at our institution. SUMMARY OF BACKGROUND DATA: Early readmission after spine surgery is being used as a proxy for quality of care. One-fifth of patients are rehospitalized within 30 days after spine surgery. Nearly 60% of these readmissions are unplanned, which translates into billions of dollars in healthcare costs...
April 1, 2017: Spine
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