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https://www.readbyqxmd.com/read/28328565/control-of-walking-speed-in-children-with-cerebral-palsy
#1
Jon R Davids, Nina Q Cung, Suzy Chen, Mitell Sison-Williamson, Anita M Bagley
BACKGROUND: Children's ability to control the speed of gait is important for a wide range of activities. It is thought that the ability to increase the speed of gait for children with cerebral palsy (CP) is common. This study considered 3 hypotheses: (1) most ambulatory children with CP can increase gait speed, (2) the characteristics of free (self-selected) and fast walking are related to motor impairment level, and (3) the strategies used to increase gait speed are distinct among these levels...
March 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28327612/endogenous-opioids-regulate-moment-to-moment-neuronal-communication-and-excitability
#2
Bryony L Winters, Gabrielle C Gregoriou, Sarah A Kissiwaa, Oliver A Wells, Danashi I Medagoda, Sam M Hermes, Neil T Burford, Andrew Alt, Sue A Aicher, Elena E Bagley
Fear and emotional learning are modulated by endogenous opioids but the cellular basis for this is unknown. The intercalated cells (ITCs) gate amygdala output and thus regulate the fear response. Here we find endogenous opioids are released by synaptic stimulation to act via two distinct mechanisms within the main ITC cluster. Endogenously released opioids inhibit glutamate release through the δ-opioid receptor (DOR), an effect potentiated by a DOR-positive allosteric modulator. Postsynaptically, the opioids activate a potassium conductance through the μ-opioid receptor (MOR), suggesting for the first time that endogenously released opioids directly regulate neuronal excitability...
March 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28322594/development-of-endoscopic-diagnosis-and-treatment-for-chronic-unilateral-hematuria-35-years-experience
#3
Ryuta Tanimoto, Hiromi Kumon, Demetrius H Bagley
PURPOSE: Chronic unilateral hematuria (CUH) is also called lateralizing essential hematuria, benign essential hematuria, and benign lateralizing hematuria, which was defined as intermittent or continuous gross hematuria that cannot be diagnosed with standard radiology and hematology studies, together with unilateral bloody efflux by cystoscopy. CUH is rare, but sometimes confused with malignancy or life threatening hemorrhage. Therefore, it can cause considerable anxiety to not only patients but also urologists...
March 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28298505/ultrasound-safety-can-we-do-better
#4
Jennifer Bagley
No abstract text is available yet for this article.
March 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28296521/speech-language-pathology-intervention-in-a-youth-justice-setting-benefits-perceived-by-staff-extend-beyond-communication
#5
Pamela C Snow, Kerryn Bagley, Donna White
PURPOSE: Young people in youth justice (YJ) settings face high-risk for unidentified language disorder, however, speech-language pathology (SLP) services are not routinely offered in such settings. The aim of this study was to explore and describe the perceptions and experiences of YJ staff in a custodial centre of the utility of having a speech-language pathologist working with young offenders. METHOD: Following a SLP intervention trial, two staff focus groups were conducted by an independent SLP...
March 15, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28285682/pretreatment-neutrophil-to-lymphocyte-ratio-as-a-marker-of-outcomes-in-nivolumab-treated-patients-with-advanced-non-small-cell-lung-cancer
#6
Stephen J Bagley, Shawn Kothari, Charu Aggarwal, Joshua M Bauml, Evan W Alley, Tracey L Evans, John A Kosteva, Christine A Ciunci, Peter E Gabriel, Jeffrey C Thompson, Susan Stonehouse-Lee, Victoria E Sherry, Elizabeth Gilbert, Beth Eaby-Sandy, Faith Mutale, Gloria DiLullo, Roger B Cohen, Anil Vachani, Corey J Langer
OBJECTIVES: Efficient use of nivolumab in non-small-cell lung cancer (NSCLC) has been limited by the lack of a definitive predictive biomarker. In patients with metastatic melanoma treated with ipilimumab, a pretreatment neutrophil-to-lymphocyte ratio (NLR)<5 has been associated with improved survival. This retrospective cohort study aimed to determine whether the pretreatment NLR was associated with outcomes in NSCLC patients treated with nivolumab. METHODS: We reviewed the medical records of all patients with previously treated advanced NSCLC who received nivolumab between March 2015 and March 2016 outside of a clinical trial at the University of Pennsylvania...
April 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28263126/fluorescence-in-situ-hybridization-fish-in-the-diagnosis-of-bladder-and-upper-tract-urothelial-carcinoma-the-largest-single-institution-experience-to-date
#7
Leonard G Gomella, Mark J Mann, Ryan C Cleary, Scott G Hubosky, Demetrius H Bagley, Adeep B Thumar, Peter A McCue, Costas D Lallas, Edouard J Trabulsi
INTRODUCTION: We evaluated the UroVysion (Abbott Molecular, IL, USA) fluorescence in situ hybridization (FISH) assay for the diagnosis of urothelial cancer in patients diagnosed with or suspected to have bladder, upper tract urothelial carcinoma (UTUC), and combined upper and lower tract urothelial carcinoma (BC). MATERIALS AND METHODS: A single institution retrospective analysis comparing sensitivity, specificity, positive predictive value, and negative predictive values for FISH and urinary cytology...
February 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28251485/endoscopic-treatment-of-upper-tract-urothelial-carcinoma
#8
REVIEW
Daniel P Verges, Costas D Lallas, Scott G Hubosky, Demetrius H Bagley
PURPOSE OF REVIEW: This study aims to make the reader be aware of recent trends regarding the endoscopic management of upper tract urothelial carcinoma (UTUC) via review of the urologic literature over the past 5 years. Given the rare incidence of this disease, and the lack of level 1 evidence, systematic reviews and meta-analyses were also evaluated. Studies of importance are also considered and outlined in the annotated reference section. RECENT FINDINGS: The PubMed database was queried using the following medical subject headings (MeSH terms): "carcinoma, transitional cell," "ureter," "ureteral neoplasms," "kidney pelvis," "endoscopy," "laser therapy," "ureteroscopy," "urologic surgical procedures," and "ureteroscopes...
April 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28242610/stomach-curvature-is-generated-by-left-right-asymmetric-gut-morphogenesis
#9
Adam Davis, Nirav M Amin, Caroline Johnson, Kristen Bagley, H Troy Ghashghaei, Nanette Nascone-Yoder
Left-right (LR) asymmetry is a fundamental feature of internal anatomy, yet the emergence of morphological asymmetry remains one of the least understood phases of organogenesis. Asymmetric rotation of the intestine is directed by forces outside of the gut, but the morphogenetic events that generate anatomical asymmetry in other regions of the digestive tract remain unknown. Here we show that the mechanisms that drive the curvature of the stomach are intrinsic to the gut tube itself. The left wall of the primitive stomach expands more than the right wall, as the left epithelium becomes more polarized and undergoes radial rearrangement...
February 27, 2017: Development
https://www.readbyqxmd.com/read/28224062/correction-hydration-status-as-a-predictor-of-high-altitude-mountaineering-performance
#10
Eric Ladd, Katherine M Shea, Patrick Bagley, Sean Rundell, Paul S Auerbach, Elizabeth A Pirrotta, Ewen Wang, Grant S Lipman
[This corrects the article DOI: 10.7759/cureus.918.].
February 16, 2017: Curēus
https://www.readbyqxmd.com/read/28192260/risk-factors-and-independent-predictors-of-30-day-readmission-for-altered-mental-status-after-elective-spine-surgery-for-spine-deformity-a-single-institutional-study-of-1090-patients
#11
Aladine A Elsamadicy, Owoicho Adogwa, Gireesh B Reddy, Amanda Sergesketter, Hunter Warwick, Terrell Jones, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: Altered Mental Status (AMS) has been associated with inferior surgical outcomes. The factors leading to AMS after spine surgery are unknown. The aim of this study is to determine the risk factors and independent predictors of 30-day readmission for AMS in spine deformity patients after undergoing elective spine surgery. METHODS: The medical records of 1090 adult (≥18 years old) spine deformity patients undergoing elective spine surgery at a major academic institution from 2005 to 2015 were reviewed...
February 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28175462/315%C3%A2-race-as-a-predictor-of-postoperative-hospital-readmission-after-spine-surgery
#12
Joel Martin, Timothy Y Wang, Daniel B Loriaux, Rupen Desai, Owoicho Adogwa, Maragatha Kuchibhatla, Isaac O Karikari, Carlos Antonio Bagley, Oren N Gottfried
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28168606/strategies-for-translating-evidence-based-medicine-in-lung-cancer-into-community-practice
#13
REVIEW
Stephen A Rosenberg, Andrew M Baschnagel, Stephen J Bagley, Nadine Housri
The landscape of non-small cell lung cancer (NSCLC) treatment has rapidly evolved over the past decade. This is exemplified by the use of molecular targeted agents, immunotherapies, and newer technologies such as stereotactic body radiotherapy (SBRT). As the translation of preclinical discoveries into clinical practice continues, the effective dissemination and implementation of evidence-based treatment of NSCLC will remain a foremost challenge for oncologists. To further extend evidence-based medicine into the community setting, community oncologists are being engaged on multiple fronts including leadership and participation in national clinical trials and utilization of internet-based resources...
January 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28118056/multi-faceted-quality-improvement-initiative-to-decrease-pediatric-asthma-readmissions
#14
Nadia L Krupp, Cindy Fiscus, Russell Webb, Emily C Webber, Teresa Stanley, Rebecca Pettit, Ashley Davis, Judy Hollingsworth, Deborah Bagley, Marjorie McCaskey, John C Stevens, Andrea Weist, A Ioana Cristea, Heather Warhurst, Benjamin Bauer, Michele Saysana, Gregory S Montgomery, Michelle S Howenstine, Stephanie D Davis
BACKGROUND: Asthma is the most common chronic disease of childhood, and a leading cause of hospitalization in children. A primary goal of asthma control is prevention of hospitalizations. A hospital admission is the single strongest predictor of future hospital admissions for asthma. The 30-day asthma readmission rate at our institution was significantly above that of other hospitals in the Children's Hospital Association. As a result, a multi-faceted quality improvement project was undertaken with the goal of reducing the 30-day inpatient asthma readmission rate by 50% within two years...
January 24, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28086944/prenatal-treatment-for-opioid-dependency-observations-from-a-large-inner-city-clinic
#15
Kelley Saia, Sarah M Bagley, Elisha M Wachman, Payal P Patel, Marisa D Nadas, Susan B Brogly
BACKGROUND: The objective of this study was to review changes in the prevalence of opioid use disorder in pregnancy, and to describe the prenatal care and neonatal outcomes following the implementation of buprenorphine treatment at a large US obstetrical clinic during the on-going opioid epidemic. METHODS: We conducted a retrospective cohort study of 310 women (332 pregnancies) with opioid use disorders and their neonates delivered between June 2006 and December 2010 at an obstetrical clinic in the US...
January 13, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28028850/history-geography-and-host-use-shape-genomewide-patterns-of-genetic-variation-in-the-redheaded-pine-sawfly-neodiprion-lecontei
#16
Robin K Bagley, Vitor C Sousa, Matthew L Niemiller, Catherine R Linnen
Divergent host use has long been suspected to drive population differentiation and speciation in plant-feeding insects. Evaluating the contribution of divergent host use to genetic differentiation can be difficult, however, as dispersal limitation and population structure may also influence patterns of genetic variation. In this study, we use double-digest restriction-associated DNA (ddRAD) sequencing to test the hypothesis that divergent host use contributes to genetic differentiation among populations of the redheaded pine sawfly (Neodiprion lecontei), a widespread pest that uses multiple Pinus hosts throughout its range in eastern North America...
February 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28003170/impact-of-race-on-30-day-complication-rates-after-elective-complex-spinal-fusion-%C3%A2-5-levels-a-single-institutional-study-of-446-patients
#17
Aladine A Elsamadicy, Owoicho Adogwa, Amanda Sergesketter, Cassie Hobbs, Shay Behrens, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
OBJECTIVE: Racial disparities have been shown to affect surgical outcomes. However, the effect of race on complex spinal fusion outcomes remains understudied. The aim of this study is to determine if patient race affects 30-day complication rates after elective complex spinal fusion (≥5 levels). METHODS: The medical records of 490 adult patients with spinal deformity undergoing elective complex spinal fusion (≥5 levels) at a major academic institution from 2005 to 2015 were reviewed...
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28002116/crossing-borders-an-online-interdisciplinary-course-in-health-informatics-for-students-from-two-countries
#18
Mariann Fossum, Ann Fruhling, Carl Erik Moe, Cheryl Bagley Thompson
A cross-countries and interprofessional novel approach for delivering an international interdisciplinary graduate health informatics course online is presented. Included in this discussion are the challenges, lessons learned, and pedagogical recommendations from the experiences of teaching the course. Four professors from three different fields and from three universities collaborated in offering an international health informatics course for an interdisciplinary group of 18 US and seven Norwegian students...
December 20, 2016: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/27984439/skeletal-muscle-fatigability-and-myosin-heavy-chain-fiber-type-in-resistance-trained-men
#19
James R Bagley, Kathryn A McLeland, Jose A Arevalo, Lee E Brown, Jared W Coburn, Andrew J Galpin
Bagley, JR, McLeland, KA, Arevalo, JA, Brown, LE, Coburn, JW, and Galpin, AJ. Skeletal muscle fatigability and myosin heavy chain fiber type in resistance trained men. J Strength Cond Res 31(3): 602-607, 2017-Forty years ago, Thorstensson and Karlsson in 1976 described the link between muscle fatigability and fiber type, finding that more fast-twitch fibers were associated with a quicker onset of quadriceps fatigue. This provided the foundation for the Classic Thorstensson Test of fatigability and subsequent noninvasive fiber type prediction equation...
March 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27984277/impact-of-hyperlipidemia-on-alloimmunity
#20
Jessamyn Bagley, Jin Yuan, John Iacomini
PURPOSE OF REVIEW: Hyperlipidemia is a comorbidity affecting a significant number of transplant patients despite treatment with cholesterol lowering drugs. Recently, it has been shown that hyperlipidemia can significantly alter T-cell responses to cardiac allografts in mice, and graft rejection is accelerated in dyslipidemic mice. Here, we review recent advances in our understanding of hyperlipidemia in graft rejection. RECENT FINDINGS: Hyperlipidemic mice have significant increases in serum levels of proinflammatory cytokines, and neutralization of interleukin 17 (IL-17) slows graft rejection, suggesting that IL-17 production by Th17 cells was necessary but not sufficient for rejection...
February 2017: Current Opinion in Organ Transplantation
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