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https://www.readbyqxmd.com/read/29913516/medication-for-opioid-use-disorder-after-nonfatal-opioid-overdose-and-association-with-mortality-a-cohort-study
#1
Marc R Larochelle, Dana Bernson, Thomas Land, Thomas J Stopka, Na Wang, Ziming Xuan, Sarah M Bagley, Jane M Liebschutz, Alexander Y Walley
Background: Opioid overdose survivors have an increased risk for death. Whether use of medications for opioid use disorder (MOUD) after overdose is associated with mortality is not known. Objective: To identify MOUD use after opioid overdose and its association with all-cause and opioid-related mortality. Design: Retrospective cohort study. Setting: 7 individually linked data sets from Massachusetts government agencies...
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29870850/impact-of-chronic-obstructive-pulmonary-disease-on-post-operative-complication-rates-ambulation-and-length-of-hospital-stay-after-elective-spinal-fusion-%C3%A2-3-levels-in-elderly-spine-deformity-patients
#2
Aladine A Elsamadicy, Amanda R Sergesketter, Hanna Kemeny, Owoicho Adogwa, Aaron Tarnasky, Lefko Charalambous, David E T Lubkin, Mark A Davison, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
No abstract text is available yet for this article.
June 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29866621/reply
#3
Kymora Scotland, Scott G Hubosky, Kelly A Healy, Demetrius H Bagley
No abstract text is available yet for this article.
June 1, 2018: Urology
https://www.readbyqxmd.com/read/29860014/extended-length-of-stay-in-elderly-patients-after-lumbar-decompression-and-fusion-surgery-is-may-not-be-attributable-to-baseline-illness-severity-or-postoperative-complications
#4
Owoicho Adogwa, Shyam A Desai, Victoria D Vuong, Daniel T Lilly, Bichun Ouyang, Mark Davison, Syed Khalid, Carlos A Bagley, Joseph Cheng
BACKGROUND: Hospital leaders are seeking ways to improve resource utilization and minimize long postoperative hospital stays. Common explanations for extended stay are baseline patient illness, postoperative complications, or physician practice differences. However, the degree extended length of stay (LOS) represents illness severity or postoperative complications remains unknown. The aim is to investigate the influence of postoperative complications and patient comorbidities on extended length of stay after lumbar spine surgery in elderly patients...
May 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29796370/immediate-postoperative-pain-scores-predict-neck-pain-profile-up-to-1-year-following-anterior-cervical-discectomy-and-fusion
#5
Owoicho Adogwa, Aladine A Elsamadicy, Victoria D Vuong, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
Study Design: Retrospective cohort review. Objective: To assess whether immediate postoperative neck pain scores accurately predict 12-month visual analog scale-neck pain (VAS-NP) outcomes following Anterior Cervical Discectomy and Fusion surgery (ACDF). Methods: This was a retrospective study of 82 patients undergoing elective ACDF surgery at a major academic medical center. Patient reported outcomes measures VAS-NP scores were recorded on the first postoperative day, then at 6-weeks, 3, 6, and 12-months after surgery...
May 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29792976/simultaneous-bilateral-ureteral-calculi-a-new-paradigm-for-management
#6
Kymora B Scotland, Scott G Hubosky, Ryuta Tanimoto, Robert Cooper, Kelly A Healy, Demetrius H Bagley
OBJECTIVES: To define the need for emergent intervention between patients with SBUC compared to unilateral ureteral calculi (UUC). Patients with simultaneous bilateral ureteral calculi (SBUC) represent a potential urological emergency due to possible anuria and/or electrolyte imbalance. While conventional practice mandates immediate intervention in these patients, little data exist to define the rate of these events. METHODS: Records of all patients with ureteral stones treated ureteroscopically over an 11-year period were reviewed to identify those with SBUC...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29772370/does-nasal-carriage-of-staphylococcus-aureus-increase-the-risk-of-post-operative-infections-after-elective-spine-surgery-do-most-infections-occur-in-carriers
#7
Owoicho Adogwa, Victoria D Vuong, Aladine A Elsamadicy, Daniel T Lilly, Shyam A Desai, Syed Khalid, Joseph Cheng, Carlos A Bagley
BACKGROUND: Wound infections following adult spinal deformity surgery place a high toll on patients, providers, and the healthcare system. Staphylococcus aureus is a common cause of postoperative wound infections, and nasal colonization by this organism may be an important factor development of surgical site infections (SSI's). The aim is to investigate whether post-operative surgical site infections after elective spine surgery occur at a higher rate in patients with Methicillin-Resistant Staphylococcus Aureus (MRSA) nasal colonization...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29755047/domestic-violence-and-pregnancy-a-cbpr-coalition-approach-to-identifying-needs-and-informing-policy
#8
Candace Forbes Bright, Braden Bagley, Ivie Pulliam, Amy Swetha Newton
BACKGROUND: Community engagement-the collaborative process of addressing issues that impact the well-being of a community-is a strategic effort to address community issues. The Gulf States Health Policy Center (GS-HPC) formed the Hattiesburg Area Health Coalition (HAHC) in November 2014 for the purpose of addressing policies impacting the health of Forrest and Lamar counties in Mississippi. OBJECTIVES: To chronicle the community-based participatory research (CBPR) process used by HAHC's identification of infant and maternal health as a policy area, domestic violence in pregnancy as a priority area within infant and maternal health, and a community action plan (CAP) regarding this priority area...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29755043/domestic-violence-and-pregnancy-a-community-based-participatory-research-coalition-approach-to-identifying-needs-and-informing-policy
#9
Candace Forbes Bright, Braden Bagley, Ivie Pulliam, Amy Swetha Newton
No abstract text is available yet for this article.
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29740395/maternal-diet-metabolic-state-and-inflammatory-response-exert-unique-and-long-lasting-influences-on-offspring-behavior-in-non-human-primates
#10
Jacqueline R Thompson, Hanna C Gustafsson, Madison DeCapo, Diana L Takahashi, Jennifer L Bagley, Tyler A Dean, Paul Kievit, Damien A Fair, Elinor L Sullivan
Nutritional status influences brain health and gestational exposure to metabolic disorders (e.g. obesity and diabetes) increases the risk of neuropsychiatric disorders. The aim of the present study was to further investigate the role of maternal Western-style diet (WSD), metabolic state, and inflammatory factors in the programming of Japanese macaque offspring behavior. Utilizing structural equation modeling, we investigated the relationships between maternal diet, prepregnancy adiposity, third trimester insulin response, and plasma cytokine levels on 11-month-old offspring behavior...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29738824/radiologic-pseudoprogression-during-anti-pd1-therapy-for-advanced-non-small-cell-lung-cancer
#11
Sharyn I Katz, Mark Hammer, Stephen Bagley, Charu Aggarwal, Joshua Bauml, Jeffrey C Thompson, Arun C Nachiappan, Charles B Simone, Corey Langer
INTRODUCTION: Anti-PD1 (programmed cell death protein 1) therapy can lead to unconventional tumor responses including radiologic pseudoprogression. Here we determine the real-world incidence of radiologic pseudoprogression in advanced non-small cell lung cancer (NSCLC) and compare radiologic response criteria for disease response assessment. METHODS: Electronic medical records of all NSCLC patients receiving anti-PD1 therapy at our institution over a 3-year period were retrospectively reviewed and patients with clinically suspected radiologic pseudoprogression identified...
May 5, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29732915/retrograde-ureteroscopic-management-of-large-renal-calculi-a-single-institutional-experience-and-concise-literature-review
#12
Kymora Scotland, Benjamin Rudnick, Kelly A Healy, Scott G Hubosky, Demetrius Bagley
INTRODUCTION: Advances in flexible ureteroscope design and accessory instrumentation have allowed for more challenging cases to be treated ureteroscopically. Here we evaluate our experience with ureteroscopy for the management of large renal calculi (≥ 2cm) and provide a concise review of recent reports.. METHODS: A retrospective review was undertaken of all ureteroscopy cases between 2004 and 2014 performed by the endourologic team at a single academic tertiary care institution...
May 5, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29730987/stigma-associated-with-medication-treatment-for-young-adults-with-opioid-use-disorder-a-case-series
#13
Scott E Hadland, Tae Woo Park, Sarah M Bagley
BACKGROUND: Opioid-related overdose deaths have risen sharply among young adults. Despite this increase, access to evidence-based medication for opioid agonist treatment (OAT) for youth remains low. Among older adults, barriers to OAT include the paucity of buprenorphine-waivered prescribers and low rates of prescribing among waivered physicians. We have increasingly found in our clinical practice significant stigma related to using OAT to treat addiction for young adults. In this series, we describe three cases of young adults who faced significant stigma related to their treatment...
May 7, 2018: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29719177/reform-at-risk-mandating-participation-in-alternative-payment-plans
#14
Scott Levy, Nicholas Bagley, Rahul Rajkumar
In an ambitious effort to slow the growth of health care costs, the Affordable Care Act created the Center for Medicare and Medicaid Innovation (CMMI) and armed it with broad authority to test new approaches to reimbursement for health care (payment models) and delivery-system reforms. CMMI was..
May 3, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29707053/reliability-and-efficiency-of-three-methods-of-calculating-migration-percentage-on-radiographs-for-hip-surveillance-in-children-with-cerebral-palsy
#15
V A Kulkarni, J R Davids, A D Boyles, N Q Cung, A Bagley
Purpose: Hip surveillance programmes for children with cerebral palsy (CP) utilize the migration percentage (MP) measurement to initiate referrals and recommend treatment. This study assesses the reliability and efficiency of three methods of MP measurement on anteroposterior (AP) pelvis radiographs. Methods: A total of 20 AP pelvis radiographs (40 hips) of children with CP were measured by three raters on two occasions using three methods: digital measurement (DM) on a Picture Archiving and Communication System monitor, computer-aided measurement (CA) using a digital templating tool and mobile device application measurement (MA) using a freely available MP measurement tool...
April 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29700869/tree-nut-allergies-allergen-homology-cross-reactivity-and-implications-for-therapy
#16
REVIEW
J M Smeekens, K Bagley, M Kulis
Tree nut allergy is a potentially life-threatening disease that is increasing in prevalence, now affecting 1% of the general population in the United States. While other food allergies often resolve spontaneously, tree nut allergies are outgrown in less than 10% of cases. Due to the likelihood of cross-sensitization to multiple tree nut allergens, the current treatment guideline is strict avoidance of all nuts once one tree nut allergy has been diagnosed. For example, walnut and pecan are highly cross-reactive, along with cashew and pistachio, but the extent of clinical, IgE-mediated cross-reactivity among other tree nuts remains unclear, therefore making avoidance of all tree nuts a safe approach...
April 27, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29689404/extended-length-of-stay-in-elderly-patients-after-anterior-cervical-discectomy-and-fusion-is-not-attributable-to-baseline-illness-severity-or-postoperative-complications
#17
Owoicho Adogwa, Daniel T Lilly, Victoria D Vuong, Shyam A Desai, Bichun Ouyang, Syed Khalid, Ryan Khanna, Carlos A Bagley, Joseph Cheng
BACKGROUND: Health care systems are increasing efforts to minimize postoperative hospital stays to improve resource use. Common explanations for extended postoperative stay are baseline patient sickness, postoperative complications, or physician practice differences. However, the degree to which extended length of stay (LOS) represents patient illness or postoperative complications remains unknown. The aim is to investigate the influence of postoperative complications and elderly patient comorbidities on extended LOS after anterior cervical discectomy and fusion...
April 22, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29659047/the-changing-face-of-adult-posttransplant-lymphoproliferative-disorder-changes-in-histology-between-1999-and-2013
#18
Donald E Tsai, Stephen Bagley, Ran Reshef, Abraham Shaked, Roy D Bloom, Vivek Ahya, Lee Goldberg, Albert Chung, Fotini Debonera, Stephen J Schuster, Scott F Huntington
Posttransplant lymphoproliferative disorder (PTLD) typically presents with either polymorphic or monomorphic histology. While both are the end result of immunosuppressive therapies, their origins are felt to be different with different prognoses and responsiveness to therapy, resulting in 2 different malignancies. We attempted to confirm reports suggesting that the relative frequency of these 2 histologies is shifting over time. We analyzed 3040 adult PTLD cases in the UNOS OPTN database from 1999 to 2013. Changes in PTLD cases over time were analyzed for histology, time from transplant to diagnosis, and patient EBV serostatus...
April 16, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29627981/discovery-of-a-novel-small-molecule-modulator-of-c-x-c-chemokine-receptor-type-7-as-a-treatment-for-cardiac-fibrosis
#19
Elnaz Menhaji-Klotz, Kevin D Hesp, Allyn T Londregan, Amit S Kalgutkar, David W Piotrowski, Markus Boehm, Kun Song, Tim Ryder, Kevin Beaumont, Rhys M Jones, Karen Atkinson, Janice A Brown, John Litchfield, Jun Xiao, Daniel P Canterbury, Kristen Burford, Benjamin A Thuma, Chris Limberakis, Wenhua Jiao, Scott W Bagley, Saket Agarwal, Danielle Crowell, Stephen Pazdziorko, Jessica Ward, David A Price, Valerie Clerin
C-X-C chemokine receptor type 7 (CXCR7) is involved in cardiac and immune pathophysiology. We report the discovery of a novel 1,4-diazepine CXCR7 modulator, demonstrating for the first time the role of pharmacological CXCR7 intervention in cardiac repair. Structure-activity-relationship (SAR) studies demonstrated that a net reduction in lipophilicity (log D) and an incorporation of saturated ring systems yielded compounds with good CXCR7 potencies and improvements in oxidative metabolic stability in human-liver microsomes (HLM)...
April 26, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29615537/strong-impact-of-natural-selection-free-heterogeneity-in-genetics-of-age-related-phenotypes
#20
Alexander M Kulminski, Jian Huang, Yury Loika, Konstantin G Arbeev, Olivia Bagley, Arseniy Yashkin, Matt Duan, Irina Culminskaya
A conceptual difficulty in genetics of age-related phenotypes that make individuals vulnerable to disease in post-reproductive life is genetic heterogeneity attributed to an undefined role of evolution in establishing their molecular mechanisms. Here, we performed univariate and pleiotropic genome-wide meta-analyses of 20 age-related phenotypes leveraging longitudinal information in a sample of 33,431 individuals and dealing with the natural-selection-free genetic heterogeneity. We identified 142 non-proxy single nucleotide polymorphisms (SNPs) with phenotype-specific (18 SNPs) and pleiotropic (124 SNPs) associations at genome-wide level...
March 29, 2018: Aging
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