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Max O Krucoff, Steven Cook, Owoicho Adogwa, Jessica Moreno, Siyun Yang, Jichun Xie, Alexander O Firempong, Nandan Lad, Carlos A Bagley
OBJECT: To examine the role of race, gender, and socioeconomics on presentations and outcomes of adult Chiari 1 malformations. METHODS: The charts of 638 adult patients with Chiari 1 malformations were reviewed, and 287 patients were included. Race, gender, insurance status, symptoms, depth of cerebellar tonsillar herniation, and presence of syringomyelia were examined as covariates in multivariate logistic regression models to identify independent predictors of presentation and outcome...
October 14, 2016: World Neurosurgery
Merritt D Kinon, Rani Nasser, Jonathan Nakhla, Rupen Desai, Jessica R Moreno, Reza Yassari, Carlos A Bagley
Pediatric emergency physicians must have a high clinical suspicion for atlantoaxial rotatory subluxation (AARS), particularly when a child presents with neck pain and an abnormal head posture without the ability to return to a neutral position. As shown in the neurosurgical literature, timely diagnosis and swift initiation of treatment have a greater chance of treatment success for the patient. However, timely treatment is complicated because torticollis can result from a variety of maladies, including: congenital abnormalities involving the C1-C2 joint or the surrounding supporting muscles and ligaments, central nervous system abnormalities, obstetric palsies from brachial plexus injuries, clavicle fractures, head and neck surgery, and infection...
October 2016: Pediatric Emergency Care
Erika J Bagley, Kelly M Tu, Joseph A Buckhalt, Mona El-Sheikh
OBJECTIVE: The goal of this study was to examine links between concerns about community violence and objective and subjective sleep parameters in an adolescent sample. Sex was considered as a moderator of effects. DESIGN: The study used a cross-sectional design. PARTICIPANTS: The community-based sample included 252 adolescents (53% girls) with an average age of 15.79 years (SD = 0.81) from the Southeastern United States. The sample included 34% African American and 66% European American adolescents from a wide range of socioeconomic backgrounds...
March 2016: Sleep Health
Owoicho Adogwa, Aladine A Elsamadicy, Joseph Cheng, Carlos Bagley
BACKGROUND: The prospective acquisition of reliable patient-reported outcomes (PROs) measures demonstrating the effectiveness of spine surgery, or lack thereof, remains a challenge. The aims of this study are to compare the reliability of functional outcomes metrics obtained using full time employee (FTE) vs. non-FTE-dependent methodologies and to determine the independent predictors of response reliability using non FTE-dependent methodologies. METHODS: One hundred and nineteen adult patients (male: 65, female: 54) undergoing one- and two-level lumbar fusions at Duke University Medical Center were enrolled in this prospective study...
March 2016: J Spine Surg
Owoicho Adogwa, Aladine Elsamadicy, Elizabeth Reiser, Cole Ziegler, Kyle Freischlag, Joseph Cheng, Carlos A Bagley
BACKGROUND: The primary aim of this study was to assess and compare the complications profile as well as long-term clinical outcomes between patients undergoing an Anterior Cervical Discectomy and Fusion (ACDF) procedure with and without the use of an intra-operative microscope. METHODS: One hundred and forty adult patients (non-microscope cohort: 81; microscope cohort: 59) undergoing ACDF at a major academic medical center were included in this study. Enrollment criteria included available demographic, surgical and clinical outcome data...
March 2016: J Spine Surg
Alexander M Kulminski, Yelena Kernogitski, Irina Culminskaya, Yury Loika, Konstantin G Arbeev, Olivia Bagley, Matt Duan, Liubov Arbeeva, Svetlana V Ukraintseva, Deqing Wu, Eric Stallard, Anatoliy I Yashin
Traditionally, genomewide association studies (GWAS) have emphasized the benefits of large samples in the analyses of age-related traits rather than their specific properties. We adopted a realistic concept of genetic susceptibility to inherently heterogeneous, age-related traits driven by the elusive role of evolution in their properties. We analyzed in detail the associations of rs693 and rs562338 polymorphisms representing the Apolipoprotein B locus with endophenotypes (total cholesterol [TC] and high-density lipoprotein cholesterol) and phenotypes (myocardial infarction [MI] and survival) in four large-scale studies, which include 20 748 individuals with 2357 MI events...
September 28, 2016: Aging Cell
Susan A Holechek, Megan S McAfee, Lizbeth M Nieves, Vanessa P Guzman, Kavita Manhas, Timothy Fouts, Kenneth Bagley, Joseph N Blattman
In order for vaccines to induce efficacious immune responses against mucosally transmitted pathogens, such as HIV-1, activated lymphocytes must efficiently migrate to and enter targeted mucosal sites. We have previously shown that all-trans retinoic acid (ATRA) can be used as a vaccine adjuvant to enhance mucosal CD8(+) T cell responses during vaccination and improve protection against mucosal viral challenge. However, the ATRA formulation is incompatible with most recombinant vaccines, and the teratogenic potential of ATRA at high doses limits its usage in many clinical settings...
September 23, 2016: Vaccine
Aparupa Sengupta, Dibyendu Sarkar, Padmini Das, Saumik Panja, Chinmayi Parikh, Dilrukshi Ramanathan, Susan Bagley, Rupali Datta
Environmental contamination by antibiotics not only perturbs the ecological balance but also poses a risk to human health by promoting the development of multiantibiotic-resistant bacteria. This study focuses on identifying the biochemical pathways associated with tetracycline (TC) transformation/degradation in vetiver grass that has the potential to be used as a biological remediation system in TC-contaminated water sources. A hydroponic experimental setup was used with four initial TC concentrations (0, 5, 35, 75 ppm), and TC uptake was monitored over a 30-day period...
September 23, 2016: Environmental Science and Pollution Research International
John A Batsis, Lydia E Gill, Rebecca K Masutani, Anna M Adachi-Mejia, Heather B Blunt, Pamela J Bagley, Francisco Lopez-Jimenez, Stephen J Bartels
OBJECTIVES: To identify geriatric obesity interventions that can guide clinical recommendations. DESIGN: Systematic review using Medline (PubMed), Cochrane Central Register of Controlled Trials, Web of Science, CINAHL, EMBASE (Ovid), and PsycINFO (Proquest) from January 1, 2005, to October 12, 2015, to identify English-language randomized controlled trials. PARTICIPANTS: Individuals aged 60 and older (mean age ≥65) and classified as having obesity (body mass index ≥30 kg/m(2) )...
September 19, 2016: Journal of the American Geriatrics Society
Emily Andrisevic, David E Westberry, Linda I Pugh, Anita M Bagley, Stephanie Tanner, Jon R Davids
BACKGROUND: Excessive internal or external tibial torsion is frequently present in children with cerebral palsy. Several surgical techniques have been described to correct excessive tibial torsion, including isolated distal tibial rotation osteotomy (TRO). The anatomic changes surrounding this technique are poorly understood. The goal of the study was to examine the anatomic relationship between the tibia and fibula following isolated distal TRO in children with cerebral palsy. METHODS: Twenty patients with 29 limbs were prospectively entered for study...
October 2016: Journal of Pediatric Orthopedics
Jeffrey C Thompson, Stephanie S Yee, Andrea B Troxel, Samantha L Savitch, Ryan Fan, David Balli, David B Lieberman, Jennifer D Morrissette, Tracey L Evans, Joshua Bauml, Charu Aggarwal, John A Kosteva, Evan Alley, Christine Ciunci, Roger B Cohen, Stephen Bagley, Susan Stonehouse-Lee, Victoria E Sherry, Elizabeth Gilbert, Corey Langer, Anil Vachani, Erica L Carpenter
PURPOSE: The expanding number of targeted therapeutics for non-small cell lung cancer (NSCLC) necessitates real-time tumor genotyping, yet tissue biopsies are difficult to perform serially and often yield inadequate DNA for next-generation sequencing (NGS). We evaluated the feasibility of using cell-free circulating tumor DNA (ctDNA) NGS as a complement or alternative to tissue NGS. EXPERIMENTAL DESIGN: 112 plasma samples obtained from a consecutive study of 102 prospectively enrolled patients with advanced NSCLC were subjected to ultra-deep sequencing of up to 70 genes and matched with tissue samples, when possible...
September 6, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Aladine A Elsamadicy, Owoicho Adogwa, Victoria D Vuong, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Isaac O Karikari, Carlos A Bagley
BACKGROUND: Hospital readmission within 30-days of index surgery is receiving increased scrutiny as an indicator of poor quality of care. Accordingly, reducing readmissions achieves the dual benefit of improving quality and reducing costs. With the growing prevalence of obesity, understanding its impact on 30-day unplanned readmissions and patients' perception of health status is important for appropriate risk stratification of patients. The aim of this study is to determine if obesity is an independent risk factor for unplanned 30-day readmissions following elective spine surgery...
September 1, 2016: World Neurosurgery
Scott G Hubosky, Kelly A Healy, Amar J Raval, Costas D Lallas, Joanne Filicko-O'Hara, Demetrius H Bagley
Two cases of incidentally found follicular lymphoma during surveillance for ureteroscopically treated upper tract urothelial carcinoma with cross-sectional imaging are described. Multiple independent primary malignancies should be considered in this population.
2016: J Endourol Case Rep
Aladine A Elsamadicy, Owoicho Adogwa, Jared Fialkoff, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
BACKGROUND: Prompt decompression in clinically significant cervical stenosis is important in the prevention of neurologic sequelae. Disparities exist along the continuum on spine care, with black patients both receiving less surgery and experiencing worse post-operative outcomes. The aim of this study was to assess whether black race was an independent predictor for a prolonged time to diagnosis and treatment. METHODS: The medical records of 133 patients undergoing elective ACDF surgery at a major academic medical center between 2010 and 2012 were reviewed...
August 24, 2016: World Neurosurgery
Kelley A Saia, Davida Schiff, Elisha M Wachman, Pooja Mehta, Annmarie Vilkins, Michelle Sia, Jordana Price, Tirah Samura, Justin DeAngelis, Clark V Jackson, Sawyer F Emmer, Daniel Shaw, Sarah Bagley
PURPOSE OF THE REVIEW: Opioid use disorder in the USA is rising at an alarming rate, particularly among women of childbearing age. Pregnant women with opioid use disorder face numerous barriers to care, including limited access to treatment, stigma, and fear of legal consequences. This review of opioid use disorder in pregnancy is designed to assist health care providers caring for pregnant and postpartum women with the goal of expanding evidence-based treatment practices for this vulnerable population...
2016: Current Obstetrics and Gynecology Reports
Demetrius H Bagley
No abstract text is available yet for this article.
August 20, 2016: Urology
Aaron D Skolnik, Laurie A Loevner, Deepak M Sampathu, Jason G Newman, John Y Lee, Linda J Bagley, Kim O Learned
Schwannomas are benign nerve sheath tumors that may arise along the complex course of the cranial nerves (CNs), anywhere in the head and neck. Sound knowledge of the CN anatomy and imaging features of schwannomas is paramount for making the correct diagnosis. In this article, we review approaches to diagnosing CN schwannomas by describing their imaging characteristics and the associated clinical presentations. Relevant anatomic considerations are highlighted by using illustrative examples and key differential diagnoses categorized according to regions, which include the anterior skull base, orbit, cavernous sinus, basal cisterns, and neck...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Jon R Davids, Kevin Diaz, Thu-Ba Leba, Samuel Adams, David E Westberry, Anita M Bagley
BACKGROUND: Children who have had surgery involving the placement of an implant frequently undergo a subsequent surgery for hardware removal. The cosmesis of surgical scars following initial and subsequent surgeries is unpredictable. Scar incision (subsequent surgical incision through the initial scar) or excision (around the initial scar) is selected on the basis of the quality of the initial scar. The outcomes following these techniques have not been determined. METHODS: This prospective, consecutive case series was designed to compare outcomes following surgical scar incision versus excision at the time of implant removal in children with cerebral palsy...
August 17, 2016: Journal of Bone and Joint Surgery. American Volume
Susan Sienko, Cathleen Buckon, Eileen Fowler, Anita Bagley, Loretta Staudt, Mitell Sison-Williamson, Kathy Zebracki, Craig M McDonald, Michael Sussman
The aim of this study was to determine whether prednisone and deflazacort play a different role in child behavior and perceived health related psychosocial quality of life in ambulant boys with Duchenne Muscular Dystrophy. As part of a prospective natural-history study, parents of sixty-seven ambulant boys with DMD (27 taking prednisone, 15 taking deflazacort, 25 were steroid naïve) completed the Child Behavior Checklist (CBCL) for assessment of behavioral, emotional and social problems and both parents and boys with DMD completed the PedsQL™4...
2016: PLoS Currents
Steven Bradburn, Jamie S McPhee, Liam Bagley, Sarianna Sipila, Lauri Stenroth, Marco Vincenzo Narici, Mati Pääsuke, Helena Gapeyeva, Gabrielle Osborne, Lorraine Sassano, Carel G M Meskers, Andrea B Maier, Jean-Yves Hogrel, Yoann Barnouin, Gillian Butler-Browne, Chris Murgatroyd
INTRODUCTION: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults. METHODS: this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry...
August 11, 2016: Age and Ageing
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