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Owoicho Adogwa, Daniel T Lilly, Victoria D Vuong, Shyam A Desai, Bichun Ouyang, Syed Khalid, Ryan Khanna, Carlos A Bagley, Joseph Cheng
BACKGROUND: Healthcare systems are increasing efforts to minimize postoperative hospital stays to improve resource use. Common explanations for extended postoperative stay are baseline patient sickness, postoperative complications, or physician practice differences. However, the degree extended length of stay (LOS) represents patient illness or postoperative complications remains unknown. The aim is to investigate the influence of postoperative complications and elderly patient comorbidities on extended LOS after anterior cervical discectomy and fusion (ACDF)...
April 21, 2018: World Neurosurgery
Donald E Tsai, Stephen Bagley, Ran Reshef, Abraham Shaked, Roy D Bloom, Vivek Ahya, Lee Goldberg, Albert Chung, Fotini Debonera, Stephen J Schuster, Scott F Huntington
Posttransplant lymphoproliferative disorder (PTLD) typically presents with either polymorphic or monomorphic histology. While both are the end result of immunosuppressive therapies, their origins are felt to be different with different prognoses and responsiveness to therapy, resulting in two different malignancies. We attempted to confirm reports suggesting that the relative frequency of these two histologies is shifting over time. We analyzed 3040 adult PTLD cases in the UNOS OPTN database from 1999 to 2013...
April 16, 2018: American Journal of Hematology
Elnaz Menhaji-Klotz, Kevin D Hesp, Allyn Timothy Londregan, Amit S Kalgutkar, David W Piotrowski, Markus Boehm, Kun Song, Tim Ryder, Kevin Beaumont, Rhys M Jones, Karen Atkinson, Janice A Brown, John Litchfield, Jun Xiao, Daniel P Canterbury, Kristen Burford, Benjamin A Thuma, Chris Limberakis, Wenhua Jiao, Scott W Bagley, Saket Agarwal, Danielle Crowell, Stephen Pazdziorko, Jessica Ward, David A Price, Valerie Clerin
C-X-C chemokine receptor type 7 (CXCR7) is involved in cardiac and immune pathophysiology. We report the discovery of a novel 1,4-diazepine CXCR7 modulator, demonstrating for the first time, the role of pharmacological CXCR7 intervention in cardiac repair. Structure-activity relationship (SAR) studies demonstrated that a net reduction in lipophilicity (logD) and incorporation of saturated ring systems yielded compounds with good CXCR7 potency and improvements in oxidative metabolic stability in human liver microsomes (HLM)...
April 8, 2018: Journal of Medicinal Chemistry
Alexander M Kulminski, Jian Huang, Yury Loika, Konstantin G Arbeev, Olivia Bagley, Arseniy Yashkin, Matt Duan, Irina Culminskaya
A conceptual difficulty in genetics of age-related phenotypes that make individuals vulnerable to disease in post-reproductive life is genetic heterogeneity attributed to an undefined role of evolution in establishing their molecular mechanisms. Here, we performed univariate and pleiotropic genome-wide meta-analyses of 20 age-related phenotypes leveraging longitudinal information in a sample of 33,431 individuals and dealing with the natural-selection-free genetic heterogeneity. We identified 142 non-proxy single nucleotide polymorphisms (SNPs) with phenotype-specific (18 SNPs) and pleiotropic (124 SNPs) associations at genome-wide level...
March 29, 2018: Aging
Mark Hammer, Stephen Bagley, Charu Aggarwal, Joshua Bauml, Arun Nachiappan, Charles B Simone, Corey Langer, Sharyn I Katz
PURPOSE: Treatment with anti-programmed death receptor-1 (PD-1) therapeutics can lead to unconventional responses and side effect profiles due to their potentiating effects on the immune system. Here we evaluate the radiologic manifestations of anti-PD-1 therapy in the chest in patients with non-small cell lung cancer (NSCLC) receiving anti-PD-1 therapy. MATERIALS AND METHODS: A retrospective review of real-world clinical practice was conducted of all the patients with NSCLC receiving anti-PD-1 therapy at our institution between 2013 and 2016...
January 31, 2018: Current Problems in Diagnostic Radiology
Robert L Dow, Mark Ammirati, Scott W Bagley, Samit K Bhattacharya, Leonard Buckbinder, Christian Cortes, Ayman F El-Kattan, Kristen Ford, Gary B Freeman, Cristiano R W Guimaraes, Shenping Liu, Mark Niosi, Athanasia Skoura, David Tess
Studies have linked the serine-threonine kinase MAP4K4 to the regulation of a number of biological processes/diseases including diabetes, cancer, inflammation and angiogenesis. With a majority of the members of our lead series (e.g. 1) suffer-ing from time-dependent inhibition of CYP3A4, we sought design avenues that would eliminate this risk. One such approach arose from the observation that carboxylic acid-based intermediates employed in our discovery efforts retained potent MAP4K4 inhibitory potency and were devoid of the TDI risk...
March 23, 2018: Journal of Medicinal Chemistry
Kimberly A Bagley, Sarah E Dunn, Eliseu Y Chuang, Victoria J Dorr, Julie A Thompson, Sophia K Smith
BACKGROUND: A community hospital combined its medical and surgical patients with cancer on one unit, which resulted in nurses not trained in oncology caring for this patient population. OBJECTIVES: The Oncology Intensives Initiative (ONCii) involved the (a) design and implementation of a daylong didactic boot camp class and a four-hour simulation session and (b) the examination of nurses' worries, attitudes, self-efficacy, and perception of interdisciplinary teamwork...
April 1, 2018: Clinical Journal of Oncology Nursing
Liam Bagley, Nasser Al-Shanti, Steven Bradburn, Osamah Baig, Mark Slevin, Jamie S McPhee
BACKGROUND: Regular sprint interval training (SIT) improves whole-body aerobic capacity and muscle oxidative potential, but very little is known about knee extensor anabolic or fatigue resistance adaptations, or whether effects are similar for males and females. The purpose of this study was to compare sex-related differences in knee extensor size, torque-velocity relationship and fatigability adaptations to 12 weeks SIT. METHODS: Sixteen males and fifteen females (mean (SEM) age: 41 (±2...
March 12, 2018: Journal of Strength and Conditioning Research
Stephen J Bagley, Arati S Desai, Gerald P Linette, Carl H June, Donald M O'Rourke
In patients with certain hematologic malignancies, the use of autologous T cells genetically modified to express chimeric antigen receptors (CARs) has led to unprecedented clinical responses. Although progress in solid tumors has been elusive, recent clinical studies have demonstrated the feasibility and safety of CAR T cell therapy for glioblastoma. In addition, despite formidable barriers to T cell localization and effector function in glioblastoma, signs of efficacy have been observed in select patients...
March 2, 2018: Neuro-oncology
Philippa R Pavia, Allyson C Berent, Chick W Weisse, Dana Neiman, Kenneth Lamb, Demetrius Bagley
OBJECTIVE To describe the technique and short- and long-term outcomes for dogs undergoing double-pigtail ureteral stent placement for treatment of benign ureteral obstruction. DESIGN Retrospective case series. ANIMALS 44 dogs (57 ureters). PROCEDURES Medical records of dogs that underwent ureteral stenting for treatment of benign ureteral obstruction between 2010 and 2013 were reviewed. Signal-ment, history, pertinent diagnostic imaging results, endourologic and post-procedural details, duration of hospitalization, complications, and outcome (short term, 7 to 30 days; long term, > 30 days) were recorded...
March 15, 2018: Journal of the American Veterinary Medical Association
Megan Cray, Allyson C Berent, Chick W Weisse, Demetrius Bagley
CASE DESCRIPTION 4 cats were examined because of ureteral obstruction. CLINICAL FINDINGS Clinical and clinicopathologic abnormalities were nonspecific and included anorexia, lethargy, weight loss, anemia, leukocytosis, neutrophilia, lymphopenia, and azotemia. A diagnosis of pyonephrosis was made in all cats. The presence of bacteriuria was confirmed by means of urinalysis in 2 cats, bacterial culture of a urine sample obtained by means of preoperative cystocentesis in 2 cats, and bacterial culture of samples obtained from the renal pelvis intraoperatively in 3 cats...
March 15, 2018: Journal of the American Veterinary Medical Association
Sue Bagley
Since the 1980s, the emergency nurse practitioner (ENP) role has evolved as increasing socioeconomic pressures and changing government policy have led to new working practices in emergency departments. Similarly, a lack of consensus regarding educational support for ENPs and the regulation of ENP training, mean that variations remain in the scope of practice, role description and academic requirements for ENPs. AIM: To explore ENPs' perceptions of their changing role, including their educational requirements and whether their training needs are being met...
February 21, 2018: Nursing Standard
David J Disabato, Jerome L Short, Diane M Lameira, Karen D Bagley, Stephanie J Wong
OBJECTIVES: This study sought to replicate and extend research on social facilitators of college student's help seeking for psychological problems. PARTICIPANTS: We collected data on 420 ethnically diverse college students at a large public university (September 2008 - May 2010). METHODS: Students completed a cross-sectional online survey. RESULTS: We found that students who were aware of close others' (e.g., family, friends) help seeking were two times more likely to have sought formal (e...
February 15, 2018: Journal of American College Health: J of ACH
James B McGivney, Andrew T Csordas, Faye M Walker, Elizabeth R Bagley, Emily M Gruber, Peter L Mage, Jose Casas-Finet, Margaret A Nakamoto, Michael Eisenstein, Christopher J Larkin, Robert J Strouse, H Tom Soh
Biologic drugs are typically manufactured in mammalian host cells, and it is critical from a drug safety and efficacy perspective to detect and remove host cell proteins (HCPs) during production. This is currently achieved with sets of polyclonal antibodies (pAbs), but these suffer from critical shortcomings because their composition is inherently undefined, and they cannot detect nonimmunogenic HCPs. In this work, we report a high-throughput screening and array-based binding characterization strategy that we employed to generate a set of aptamers that overcomes these limitations to achieve sensitive, broad-spectrum detection of HCPs from the widely used Chinese hamster ovary (CHO) cell line...
February 13, 2018: Analytical Chemistry
Mitra Menon, Justin C Bagley, Christopher J Friedline, Amy V Whipple, Anna W Schoettle, Alejandro Leal-Saenz, Christian Wehenkel, Francisco Molina-Freaner, Lluvia Flores-Renteria, M Socorro Gonzalez-Elizondo, Richard A Sniezko, Samuel A Cushman, Kristen M Waring, Andrew J Eckert
Interactions between extrinsic factors, such as disruptive selection, and intrinsic factors, such as genetic incompatibilities among loci, often contribute towards the maintenance of species boundaries. The relative roles of these factors in the establishment of reproductive isolation can be examined using species pairs characterized by gene flow throughout their divergence history. We investigated the process of speciation and the maintenance of species boundaries between Pinus strobiformis and P. flexilis...
February 7, 2018: Molecular Ecology
M Ali Fazal, Caroline Bagley, Parag Garg
PURPOSE: The aim of our study was to determine predictive factors and requirement for perioperative blood transfusion in elderly patients with extra capsular hip fractures treated with cephalo-medullary device. METHODS: Seventy-nine patients with extra capsular hip fractures treated with cephalo-medullary nailing were included in the study. Age, sex, ASA grade, timing of surgery, preoperative and postoperative haemoglobin, length of hospital stay, fracture type, number of units transfused and 30-day mortality were recorded...
December 8, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
Jon R Davids, Nina Q Cung, Robin Pomeroy, Brooke Schultz, Leslie Torburn, Vedant A Kulkarni, Sean Brown, Anita M Bagley
BACKGROUND: Abnormal hip rotation is a common deviation in children with cerebral palsy (CP). Clinicians typically assess hip rotation during gait by observing the direction that the patella points relative to the path of walking, which is referred to as the knee progression angle (KPA). Two kinematic methods for calculating the KPA are compared with each other. Video-based qualitative assessment of KPA is compared with the quantitative methods to determine reliability and validity. METHODS: The KPA was calculated by both direct and indirect methods for 32 typically developing (TD) children and a convenience cohort of 43 children with hemiplegic type CP...
April 2018: Journal of Pediatric Orthopedics
Nicholas Bagley
No abstract text is available yet for this article.
January 30, 2018: JAMA: the Journal of the American Medical Association
Steven Woloshin, Lisa M Schwartz, Pamela J Bagley, Heather B Blunt, Brian White
No abstract text is available yet for this article.
January 23, 2018: JAMA: the Journal of the American Medical Association
Irene S Tobias, Kara K Lazauskas, Jose A Arevalo, James R Bagley, Lee E Brown, Andrew J Galpin
Human skeletal muscle is a heterogeneous mixture of multiple fiber types (FT). Unfortunately, present methods for FT-specific study are constrained by limits of protein detection in single-fiber samples. These limitations beget compensatory resource-intensive procedures, ultimately dissuading investigators from pursuing FT-specific research. Additionally, previous studies neglected hybrid FT, confining their analyses to only pure FT. Here we present novel methods of protein detection across a wider spectrum of human skeletal muscle FT using fully automated capillary nanoimmunoassay (CNIA) technology...
April 1, 2018: Journal of Applied Physiology
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