Wei Wang, Robin K Yuan, Jude F Mitchell, Kirsi-Marja Zitting, Melissa A St Hilaire, James K Wyatt, Frank A J L Scheer, Kenneth P Wright, Emery N Brown, Joseph M Ronda, Elizabeth B Klerman, Jeanne F Duffy, Derk-Jan Dijk, Charles A Czeisler
Circadian clocks drive cyclic variations in many aspects of physiology, but some daily variations are evoked by periodic changes in the environment or sleep-wake state and associated behaviors, such as changes in posture, light levels, fasting or eating, rest or activity and social interactions; thus, it is often important to quantify the relative contributions of these factors. Yet, circadian rhythms and these evoked effects cannot be separated under typical 24-h day conditions, because circadian phase and the length of time awake or asleep co-vary...
February 2023: Nature Protocols