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https://www.readbyqxmd.com/read/28647949/the-key-to-adrenal-insufficiency-education-repetition-repetition-repetition
#1
Margaret F Keil, Carol Van Ryzin
Described more than 150 years ago by Thomas Addison, adrenal gland dysfunction, while treatable, remains a clinically significant and potentially fatal disease. Vague and non-specific symptomatology can delay diagnosis of adrenal insufficiency and lead to adrenal crisis. Affected individuals may delay self-management due to knowledge deficits or lack of required therapies. Advanced practice nurses must remain vigilant for signs and symptoms of adrenal insufficiency and prevention of crisis. Education of patients and their caregivers/family members must emphasize early intervention with regards to adrenal insufficiency in order to prevent adrenal crisis...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28647656/delayed-retroclival-and-cervical-spinal-subdural-hematoma-complicated-by-pre-existing-chiari-malformation-in-an-adult-trauma-patient
#2
Ha Nguyen, Hoon Choi, Shekar Kurpad, Hesham Soliman
INTRODUCTION: Traumatic spinal subdural hematoma involving the retroclival region and upper cervical spine is a rare pathology. To our knowledge, there have only been two prior cases in an adult trauma patient. We describe a patient with pre-existing Chiari 1 malformation, who recently sustained a unilateral Type 1 OCF (occipital condyle fracture) with associated disruption of the tectorial membrane and transverse ligament, that returned with a retroclival subdural hematoma extending down to C7, causing spinal cord compression and symptomatic obstructive hydrocephalus...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28647104/-french-haemovigilance-from-1994-to-nowadays-evolution-and-prospects
#3
B Lassale, G Daurat, M Besse-Moreau, J-P Aullen
Born in France in 1993, haemovigilance aims at monitoring the blood transfusion chain from the donor to the recipient, receiving labile blood products. It differs from the other vigilances due to its organization and its completeness dealing with the collected information. Prior to the European directive, the French agency created a new gravity level: grade 0, aiming at reporting and analyzing the blood transfusion chain dysfunction. Thus, haemovigilance gradually integrates the management of the risks and is given new missions in hospitals and private hospitals...
June 21, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28646879/discovery-of-a-single-male-aedes-aegypti-l-in-merseyside-england
#4
Thom Dallimore, Tony Hunter, Jolyon M Medlock, Alexander G C Vaux, Ralph E Harbach, Clare Strode
BACKGROUND: The mosquito Aedes aegypti (L.) is found in tropical and sub-tropical regions where it is the major vector of dengue fever, yellow fever, chikungunya and more recently Zika virus. Given its importance as a vector of arboviruses and its propensity to be transported to new regions, the European Centre for Disease Prevention and Control (ECDC) has placed Ae. aegypti on a list of potentially invasive mosquito species. It was previously reported in the United Kingdom (UK) in 1865 and 1919 but did not establish on either occasion...
June 24, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28646451/regulation-of-sustained-attention-false-alarm-responding-and-implementation-of-conditional-rules-by-prefrontal-gabaa-transmission-comparison-with-nmda-transmission
#5
Meagan L Auger, Juliet Meccia, Stan B Floresco
RATIONALE: Both prefrontal cortex (PFC) GABAA and NMDA transmission regulate attentional processes, yet how they may differentially regulate signal detection or other aspects of attention is unclear. OBJECTIVES: We examined PFC GABAA and NMDA receptor regulation of attention using a sustained attention task (SAT) permitting identification of distinct forms of impairments. As this task requires implementation of conditional rules, we also investigated how reducing PFC GABA transmission affected performance of visual and auditory conditional discriminations...
June 24, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28645320/acromegaly-discovered-during-a-routine-out-patient-surgical-procedure-a-case-report
#6
Chukwudi O Chiaghana, Julia M Bauerfeind, Cheri A Sulek, J Christopher Goldstein, Caleb A Awoniyi
BACKGROUND: Acromegaly is a rare syndrome in which there is unregulated hypersecretion of growth hormone. The anesthetic management of patients with this disorder is particularly challenging due to pre-existing cardiovascular and respiratory dysfunction, as well as recognized difficulties with airway management. Because of the insidious progression of the disease and the presence of nonspecific signs and symptoms, diagnosis is often made late when characteristic acromegalic features become apparent...
June 24, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28645000/manipulating-cues-in-mind-wandering-verbal-cues-affect-the-frequency-and-the-temporal-focus-of-mind-wandering
#7
Manila Vannucci, Claudia Pelagatti, Igor Marchetti
Our understanding of mind wandering (MW) has dramatically increased over the past decade. A key challenge still facing research is the identification of the processes and events that directly cause and control its occurrence. In the present study we sought to shed light on this question, by investigating the effects of verbal cues on the frequency and temporal focus of MW. To this aim, we experimentally manipulated the presence of irrelevant verbal cues during a vigilance task, in two independent groups (Verbal-cues group vs...
June 20, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28644222/pas-public-awareness-and-the-popular-media
#8
Reginald D Carter, Ruth Ballweg
From the very beginning, popular media has played an essential role in driving public awareness and recognition of physician assistants (PAs) as major contributors to healthcare. But for PAs, popular media can be a double-edged sword. Over time, the roles of PAs have evolved from bit players to leading characters on television medical dramas. Even so, on some occasions, the roles of PAs have been marginalized and misrepresented. In the future, the PA profession will need to remain vigilant about how PAs are portrayed in the popular media and must learn how to use the full benefit of the media to promote the profession's diversity, flexibility, collegiality, and civic-mindedness...
July 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28642476/prevention-of-long-term-memory-loss-after-retrieval-by-an-endogenous-camkii-inhibitor
#9
Fabio Antonio Vigil, Keiko Mizuno, Walter Lucchesi, Victoria Valls-Comamala, Karl Peter Giese
CaMK2N1 and CaMK2N2 are endogenous inhibitors of calcium/calmodulin-dependent protein kinase II (CaMKII), a key synaptic signaling molecule for learning and memory. Here, we investigated the learning and memory function of CaMK2N1 by knocking-down its expression in dorsal hippocampus of mice. We found that reduced CaMK2N1 expression does not affect contextual fear long-term memory (LTM) formation. However, we show that it impairs maintenance of established LTM, but only if retrieval occurs. CaMK2N1 knockdown prevents a decrease of threonine-286 (T286) autophosphorylation of αCaMKII and increases GluA1 levels in hippocampal synapses after retrieval of contextual fear LTM...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28639818/a-critical-examination-of-the-research-and-theoretical-underpinnings-discussed-in-thomson-besner-and-smilek-2016
#10
Nicholas W Fraulini, Gabriella M Hancock, Alexis R Neigel, Victoria L Claypoole, James L Szalma
Thomson, Besner, and Smilek (2016) propose that performance decrements associated with sustained attention are not consistently the result of a decline in perceptual sensitivity. Thomson et al. (2016) present empirical evidence using a novel, nontraditional vigilance task to support their assumptions. However, in the present rebuttal, we argue that the authors have not only have misinterpreted previous research in sustained attention, but also have misapplied those interpretations to their study. Thomson et al...
July 2017: Psychological Review
https://www.readbyqxmd.com/read/28638848/cytomegalovirus-infection-with-retinitis-after-brentuximab-vedotin-treatment-for-cd30-lymphoma
#11
Jean-Jacques Tudesq, Laure Vincent, Julie Lebrun, Yosr Hicheri, Ludovic Gabellier, Timothé Busetto, Corinne Merle, Nathalie Fegueux, Patrice Ceballos, Philippe Quittet, Robert Navarro, Dominique Hillaire-Buys, Guillaume Cartron
Brentuximab vedotin is an antibody-conjugated chemotherapy targeting CD30 indicated in treatment of several lymphomas. We report the first 3 cases of cytomegalovirus severe infections with retinitis following this treatment. Evolution was favorable, but relapse occurred after treatment rechallenge. We suggest vigilance about cytomegalovirus in patients treated with brentuximab vedotin.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28637525/eye-tracking-evidence-of-a-maintenance-bias-in-social-anxiety
#12
Catarina Fernandes, Susana Silva, Joana Pires, Alexandra Reis, Antónia Jimenez Ros, Luís Janeiro, Luís Faísca, Ana Teresa Martins
BACKGROUND: The mechanisms and triggers of the attentional bias in social anxiety are not yet fully determined, and the modulating role of personality traits is being increasingly acknowledged. AIMS: Our main purpose was to test whether social anxiety is associated with mechanisms of hypervigilance, avoidance (static biases), vigilance-avoidance or the maintenance of attention (dynamic biases). Our secondary goal was to explore the role of personality structure in shaping the attention bias...
June 22, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28636838/searching-for-affective-and-cognitive-restoration-examining-the-restorative-effects-of-casual-video-game-play
#13
Michael A Rupp, Richard Sweetman, Alejandra E Sosa, Janan A Smither, Daniel S McConnell
OBJECTIVE: We investigated the effects of a passive break, relaxation activity, and casual video game on affect, stress, engagement, and cognitive performance. BACKGROUND: Reducing stress and improving cognitive performance is critical across many domains. Previous studies investigated taking a break, relaxation techniques, or playing a game; however, these methods have not been compared within a single experiment. METHOD: Participants completed a baseline affective and cognitive assessment (ACA), which included the Positive and Negative Affect Schedule, shortened version of the Dundee Stress State Questionnaire, and backward digit-span...
June 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28633182/agreement-between-family-medicine-residency-program-directors-and-clerkship-directors-is-crucial-to-the-formation-of-the-next-generation-of-physicians
#14
https://www.readbyqxmd.com/read/28632163/melatonin-as-a-novel-interventional-candidate-for-fragile-x-syndrome-with-autism-spectrum-disorder-in-humans
#15
REVIEW
Jinyoung Won, Yunho Jin, Jeonghyun Choi, Sookyoung Park, Tae Ho Lee, Sang-Rae Lee, Kyu-Tae Chang, Yonggeun Hong
Fragile X syndrome (FXS) is the most common monogenic form of autism spectrum disorder (ASD). FXS with ASD results from the loss of fragile X mental retardation (fmr) gene products, including fragile X mental retardation protein (FMRP), which triggers a variety of physiological and behavioral abnormalities. This disorder is also correlated with clock components underlying behavioral circadian rhythms and, thus, a mutation of the fmr gene can result in disturbed sleep patterns and altered circadian rhythms. As a result, FXS with ASD individuals may experience dysregulation of melatonin synthesis and alterations in melatonin-dependent signaling pathways that can impair vigilance, learning, and memory abilities, and may be linked to autistic behaviors such as abnormal anxiety responses...
June 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28630552/decriminalization-and-women-s-access-to-abortion-in-australia
#16
Barbara Baird
This article considers the relationship between the decriminalization of abortion and women's access to abortion services. It focuses on the four Australian jurisdictions which are, with Canada, the only jurisdictions in the world where abortion has been removed from the criminal law. This paper draws on documentary evidence and an oral history project to give a "before and after" account of each jurisdiction. The paper assumes that the meaning and impact of decriminalization must be assessed in each local context...
June 2017: Health and Human Rights
https://www.readbyqxmd.com/read/28630324/trust-is-heritable-whereas-distrust-is-not
#17
Martin Reimann, Oliver Schilke, Karen S Cook
Why do people distrust others in social exchange? To what degree, if at all, is distrust subject to genetic influences, and thus possibly heritable, and to what degree is it nurtured by families and immediate peers who encourage young people to be vigilant and suspicious of others? Answering these questions could provide fundamental clues about the sources of individual differences in the disposition to distrust, including how they may differ from the sources of individual differences in the disposition to trust...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28630310/group-augmentation-collective-action-and-territorial-boundary-patrols-by-male-chimpanzees
#18
Kevin E Langergraber, David P Watts, Linda Vigilant, John C Mitani
How can collective action evolve when individuals benefit from cooperation regardless of whether they pay its participation costs? According to one influential perspective, collective action problems are common, especially when groups are large, but may be solved when individuals who have more to gain from the collective good or can produce it at low costs provide it to others as a byproduct. Several results from a 20-y study of one of the most striking examples of collective action in nonhuman animals, territorial boundary patrolling by male chimpanzees, are consistent with these ideas...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28628804/neuronal-substrates-of-sleep-homeostasis-lessons-from-flies-rats-and-mice
#19
REVIEW
Jeffrey M Donlea, Md Noor Alam, Ronald Szymusiak
Sleep homeostasis is a fundamental property of vigilance state regulation that is highly conserved across species. Neuronal systems and circuits that underlie sleep homeostasis are not well understood. In Drosophila, a neuronal circuit involving neurons in the ellipsoid body and in the dorsal Fan-shaped body is a candidate for both tracing sleep need during waking and translating it to increased sleep drive and expression. Sleep homeostasis in rats and mice involves multiple neuromodulators acting on multiple wake- and sleep-promoting neuronal systems...
June 16, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28628572/multimodal-analgesia-and-the-vigilance-of-heimdall
#20
Darin J Correll
No abstract text is available yet for this article.
July 2017: Anesthesia and Analgesia
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