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https://www.readbyqxmd.com/read/28430906/past-and-current-cause-specific-mortality-in-eisenmenger-syndrome
#1
Cristel M Sørensen Hjortshøj, Aleksander Kempny, Annette Schophuus Jensen, Keld Sørensen, Edit Nagy, Mikael Dellborg, Bengt Johansson, Virginija Rudiene, Gu Hong, Alexander R Opotowsky, Werner Budts, Barbara J Mulder, Lidia Tomkiewicz-Pajak, Michele D'Alto, Katja Prokšelj, Gerhard-Paul Diller, Konstantinos Dimopoulos, Mette-Elise Estensen, Henrik Holmstrøm, Maila Turanlahti, Ulf Thilén, Michael A Gatzoulis, Lars Søndergaard
Aims: Eisenmenger syndrome (ES) is associated with considerable morbidity and mortality. Therapeutic strategies have changed during the 2000s in conjunction with an emphasis on specialist follow-up. The aim of this study was to determine the cause-specific mortality in ES and evaluate any relevant changes between 1977 and 2015. Methods and results: This is a retrospective, descriptive multicentre study. A total of 1546 patients (mean age 38.7 ± 15.4 years; 36% male) from 13 countries were included...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28428772/molecular-characterization-of-staphylococcus-aureus-isolated-from-bovine-mastitis-and-close-human-contacts-in-south-african-dairy-herds-genetic-diversity-and-inter-species-host-transmission
#2
Tracy Schmidt, Marleen M Kock, Marthie M Ehlers
Staphylococcus aureus is one of the most common etiological agents of contagious bovine mastitis worldwide. The purpose of this study was to genetically characterize a collection of S. aureus isolates (bovine = 146, human = 12) recovered from cases of bovine mastitis and nasal swabs of close human contacts in the dairy environment. Isolates were screened for a combination of clinically significant antimicrobial and virulence gene markers whilst the molecular epidemiology of these isolates and possible inter-species host transmission was investigated using a combination of genotyping techniques...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28428532/ceftriaxone-induced-hemolytic-anemia-in-a-jehovah-s-witness
#3
James Tasch, Pedro Gonzalez-Zayaz
BACKGROUND Drug-induced immune hemolytic anemia (DIIHA) is a rare condition that may result from the administration of an antibiotic, most notably the cephalosporin class, commonly used in both the adult and pediatric populations. A delay in recognition by a provider may lead to continuation of the offending agent and possibly result in fatal outcomes. CASE REPORT We report the case of a 65-year-old woman on ceftriaxone infusions after being diagnosed with acute mitral valve endocarditis 3 weeks prior, which presented with severe anemia and bilateral transient vision loss...
April 21, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28426446/providing-anesthesia-in-resource-limited-settings
#4
Lena E Dohlman
PURPOSE OF REVIEW: The article reviews the reality of anesthetic resource constraints in low and middle-income countries (LMICs). Understanding these limitations is important to volunteers from high-income countries who desire to teach or safely provide anesthesia services in these countries. RECENT FINDINGS: Recently published information on the state of anesthetic resources in LMICs is helping to guide humanitarian outreach efforts from high-income countries. The importance of using context-appropriate anesthesia standards and equipment is now emphasized...
April 19, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28426132/a-parasitoid-wasp-s-odd-pupal-vigil
#5
Eric F LoPresti, Douglass H Morse
No abstract text is available yet for this article.
April 20, 2017: Ecology
https://www.readbyqxmd.com/read/28420160/global-transmission-dynamics-of-measles-in-the-measles-elimination-era
#6
Yuki Furuse, Hitoshi Oshitani
Although there have been many epidemiological reports of the inter-country transmission of measles, systematic analysis of the global transmission dynamics of the measles virus (MV) is limited. In this study, we applied phylogeographic analysis to characterize the global transmission dynamics of the MV using large-scale genetic sequence data (obtained for 7456 sequences) from 115 countries between 1954 and 2015. These analyses reveal the spatial and temporal characteristics of global transmission of the virus, especially in Australia, China, India, Japan, the UK, and the USA in the period since 1990...
April 16, 2017: Viruses
https://www.readbyqxmd.com/read/28419772/visual-memory-uniquely-predicts-anhedonia-in-schizophrenia-but-not-bipolar-disorder
#7
Anjuli S Bodapati, Lisanne M Jenkins, Rajiv P Sharma, Cherise Rosen
OBJECTIVE: Deficits in memory have been suggested as an influential mechanism of anhedonia, because while pleasant experiences may be enjoyed in-the-moment, the cognitive processes involved in reporting anticipated or remembered enjoyable experiences is thought to be impaired. This study will determine whether any aspects of memory, including visual memory, verbal memory or working memory, are significantly predictive of anhedonia in a sample of schizophrenia, psychotic bipolar disorder and healthy controls...
April 17, 2017: Journal of Neuropsychology
https://www.readbyqxmd.com/read/28419578/disordered-eating-patterns-in-coeliac-disease-a-framework-analysis
#8
R-M Satherley, S Higgs, R Howard
OBJECTIVE: The need for dietary-management in coeliac disease may lead to the development of disordered eating patterns. A theoretical model of disordered eating has been proposed to explain disordered eating in coeliac disease. The aim of this study was to explore the experiences of typical and disordered eating in coeliac disease to gain a greater understanding of these processes and explore specific pathways within this model. METHODS: We interviewed 21 individuals with coeliac disease, recruited from a previous database, about their experiences with food and food environments...
April 17, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28419373/trends-in-the-prevalence-of-morbid-obesity-among-children-and-adolescents-in-shandong-china-1995-2014
#9
Ying-Xiu Zhang, Zun-Hua Chu, Su-Yun Li, Jin-Shan Zhao, Jing-Yang Zhou
Background: : Childhood obesity has increased dramatically during the past decades; however, data on the prevalence of morbid obesity is limited. The present study examined the prevalent trends in morbid obesity among children and adolescents during the past 19 years (1995-2014) in Shandong, China. Methods: : Data for this study were obtained from five cross-sectional surveys (1995, 2000, 2005, 2010 and 2014) of schoolchildren in Shandong Province, China. A total of 41 500 students aged 7-18 years were included in this study...
April 17, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28419299/pregnancy-and-labor-complications-in-female-survivors-of-childhood-cancer-the-british-childhood-cancer-survivor-study
#10
Raoul C Reulen, Chloe J Bright, David L Winter, Miranda M Fidler, Kwok Wong, Joyeeta Guha, Julie S Kelly, Clare Frobisher, Angela B Edgar, Roderick Skinner, W Hamish B Wallace, Mike M Hawkins
Background: Female survivors of childhood cancer treated with abdominal radiotherapy who manage to conceive are at risk of delivering premature and low-birthweight offspring, but little is known about whether abdominal radiotherapy may also be associated with additional complications during pregnancy and labor. We investigated the risk of developing pregnancy and labor complications among female survivors of childhood cancer in the British Childhood Cancer Survivor Study (BCCSS). Methods: Pregnancy and labor complications were identified by linking the BCCSS cohort (n = 17 980) to the Hospital Episode Statistics (HES) for England...
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28418764/disease-surveillance-of-california-ground-squirrels-spermophilus-beecheyi-in-a-drive-through-zoo-in-oregon-usa
#11
Julia Ter Beest, Andrew Cushing, Modesto McClean, Wendy Hsu, Robert Bildfell
Rodents and other small wild mammals are often considered to be pests and vectors for disease in zoos that house small populations of valuable threatened and endangered animals. In 2005, three nonhuman primates at a drive-through zoo in Oregon, USA, acquired tularemia from an unknown source. Due to an abundance of California ground squirrels ( Spermophilus beecheyi ) on zoo grounds, we instituted serosurveillance of this species from July through September 2008 to determine the prevalence of antibodies against pathogens considered to be potentially transmissible to collection animals...
April 18, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28416929/role-of-coma-acidosis-malaria-score-in-patients-with-severe-malaria-among-indian-population-a-tertiary-care-center-experience
#12
Hari Krishan Aggarwal, Deepak Jain, Avinash Rao, Rajinish Kalra
OBJECTIVE: Malaria is a prime public health threat in developing countries like India. There is an unmet need of a simplified methodology for the purpose of triage and provision of intensive care to the severely infected patients in these areas. MATERIALS AND METHODS: We did a prospective study in patients (n=60) admitted with severe malaria in a single tertiary care center in the state of Haryana, India. We assessed the role of coma acidosis malaria (CAM) score in these patients when predicting mortality and morbidity events...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28416582/relationship-between-oxygen-concentration-and-temperature-in-an-exothermic-warming-device
#13
Ben Brooks, Charles D Deakin
INTRODUCTION: Actively warming hypothermic patients or preventing hypothermia is critical in optimising outcomes in patients with traumatic injuries. Our aim was to investigate the effect of ambient oxygen concentration on the rate and change in temperature of the TechTrade Ready-Heat II exothermic (oxygen-activated) warming blanket, to evaluate safety and ascertain the risk of thermal injury. METHODS: A mannequin covered with an exothermic blanket was placed in a sealed oxygen tent...
April 17, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28416426/-the-jard%C3%A3-law-a-real-simplification-of-research-in-france
#14
C Levy, A Rybak, R Cohen, C Jung
The Jardé law was voted in 2012 and its implementing decrees were published in November 2016. The delay between the vote and the decrees highlights the difficulties encountered. This law concerns all research, interventional and otherwise, involving the human person. Each research study must receive the approval of a randomly assigned ethics committee or Committee for the Protection of Persons. The approach here is based on risk in three types of study: interventional studies, studies with minimal risk and intervention, and non-interventional studies (observational studies)...
April 14, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28415933/incidence-risk-factors-and-the-effect-of-polyomavirus-infection-in-hematopoietic-stem-cell-transplant-recipients
#15
Jianhua Hu, Siying Li, Meifang Yang, Lichen Xu, Xuan Zhang, Hong Zhao, Huihui Dong, Yaping Huang, Jun Fan, Lanjuan Li
Objective The effect of polyomavirus infection in HSCT recipients is poorly understood. Methods We evaluated 38 HSCT recipients. Polyomavirus was detected by nested qualitative polymerase chain reaction (PCR) assays of urine. The risk factors for BK virus and JC virus were analysed. The kidney and liver functions of infected and uninfected patients were compared. Results BK virus, JC virus, and simian virus 40 were detected in 21%, 42%, and 0% of HSCT recipients respectively. HCMV infection was found to be an independent risk factor for JC virus infection (odds ratio (OR): 8...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28413694/first-neonatal-demise-with-travel-associated-zika-virus-infection-in-the-united-states-of-america
#16
Nikolaos Zacharias, Janice Whitty, Sarah Noblin, Sophia Tsakiri, Jose Garcia, Michael Covinsky, Meenakshi Bhattacharjee, David Saulino, Nina Tatevian, Sean Blackwell
Zika virus is increasingly recognized as a fetal pathogen worldwide. We describe the first case of neonatal demise with travel-associated Zika virus infection in the United States of America, including a novel prenatal ultrasound finding. A young Latina presented to our health care system in Southeast Texas for prenatal care at 23 weeks of gestation. Fetal Dandy-Walker malformation, asymmetric cerebral ventriculomegaly, single umbilical artery, hypoechoic fetal knee, dorsal foot edema, and mild polyhydramnios were noted upon initial screening prenatal sonography at 26 weeks...
April 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28411671/evidence-to-support-screening-women-in-their-40s
#17
REVIEW
Kimberly M Ray, Elissa R Price, Bonnie N Joe
A large body of evidence demonstrates a 30% to 50% mortality benefit of screening mammography for women aged 40 to 49. Because of more rapid cancer growth rates in younger women, annual screening is more effective than biennial. Studies indicate that selective screening of women aged 40 to 49 would miss the majority of breast cancers. If implemented, recent US Preventive Services Task Force breast cancer screening guidelines, which recommend against routine screening of women in their 40s, could result in thousands of preventable breast cancer deaths per year...
May 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28406674/randomization-to-randomization-probability-estimating-treatment-effects-under-actual-conditions-of-use
#18
Brandon J George, Peng Li, Harris R Lieberman, Greg Pavela, Andrew W Brown, Kevin R Fontaine, Madeline M Jeansonne, Gareth R Dutton, Adeniyi J Idigo, Mariel A Parman, Donald B Rubin, David B Allison
Blinded randomized controlled trials (RCT) require participants to be uncertain if they are receiving a treatment or placebo. Although uncertainty is ideal for isolating the treatment effect from all other potential effects, it is poorly suited for estimating the treatment effect under actual conditions of intended use-when individuals are certain that they are receiving a treatment. We propose an experimental design, randomization to randomization probabilities (R2R), which significantly improves estimates of treatment effects under actual conditions of use by manipulating participant expectations about receiving treatment...
April 13, 2017: Psychological Methods
https://www.readbyqxmd.com/read/28405956/the-impact-of-polypharmacy-and-drug-interactions-among-the-elderly-population-in-western-sicily-italy
#19
Giulia Scondotto, Fanny Pojero, Sebastiano Pollina Addario, Mauro Ferrante, Maurizio Pastorello, Michele Visconti, Salvatore Scondotto, Alessandra Casuccio
AIM: Primary endpoint was to report polypharmacy distribution in the general population vs ≥65 years old people and to examine the frequency of drug-drug interactions (DDIs) in the Health Local Unit of Palermo, Italy, in relationship with patients' age. METHODS: Drug prescription data for the year 2014 were extracted from the database of the Local Health Unit of Palermo Province, Italy. Patients were divided into five age groups (0-13, 14-64, 65-69, 70-74, and ≥75 year old)...
April 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28404200/symptoms-and-patient-factors-associated-with-diagnostic-intervals-for-pancreatic-cancer-symptom-pancreatic-study-a-prospective-cohort-study
#20
Fiona M Walter, Katie Mills, Silvia C Mendonça, Gary A Abel, Bristi Basu, Nick Carroll, Sue Ballard, John Lancaster, William Hamilton, Greg P Rubin, Jon D Emery
BACKGROUND: Pancreatic cancer is the tenth most common cancer in the UK; however, outcomes are poor, in part due to late diagnosis. We aimed to identify symptoms and other clinical and sociodemographic factors associated with pancreatic cancer diagnosis and diagnostic intervals. METHODS: We did this prospective cohort study at seven hospitals in two regions in England. We recruited participants aged 40 years or older who were referred for suspicion of pancreatic cancer...
December 2016: Lancet. Gastroenterology & Hepatology
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