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https://www.readbyqxmd.com/read/29053530/innovative-teaching-for-undergraduate-nursing-students-through-mastery-modeling
#1
Kathleen A Gordon, Kelly E Carmany, Janet R Baker, Laura M Goliat
Mastery modeling was implemented to support the transfer of classroom diabetes content to the clinical area. Interactive teaching methodologies that exemplified mastery modeling included scripted classroom video and vignettes, simulation-based learning experiences, and a worksheet relating to diabetes-specific groups to use in the clinical setting. When mastery modeling teaching methodologies were implemented, transfer of knowledge through clinical reasoning was noted at a higher level for the diabetes-specific groups over the standard groups...
October 20, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29049409/protocol-vulnerability-detection-based-on-network-traffic-analysis-and-binary-reverse-engineering
#2
Shameng Wen, Qingkun Meng, Chao Feng, Chaojing Tang
Network protocol vulnerability detection plays an important role in many domains, including protocol security analysis, application security, and network intrusion detection. In this study, by analyzing the general fuzzing method of network protocols, we propose a novel approach that combines network traffic analysis with the binary reverse engineering method. For network traffic analysis, the block-based protocol description language is introduced to construct test scripts, while the binary reverse engineering method employs the genetic algorithm with a fitness function designed to focus on code coverage...
2017: PloS One
https://www.readbyqxmd.com/read/29047143/rising-drug-costs-drives-the-growth-of-pharmacy-benefit-managers-exclusion-lists-are-exclusion-decisions-value-based
#3
Joshua P Cohen, Christelle El Khoury, Christopher-Paul Milne, Sandra M Peters
OBJECTIVE: We examine whether drugs' excluded versus recommended status on pharmacy benefit manager exclusion lists corresponds to evidence from cost-effectiveness analyses, lack of evidence, or rebates. DATA SOURCES: To find cost-effectiveness data for drugs on 2016 exclusion lists of CVS Caremark and Express Scripts, we searched the Tufts Cost-Effectiveness Analysis Registry and the peer-reviewed literature. STUDY DESIGN: For each excluded and recommended drug, we compared the mean cost-per-QALY, and we calculated the difference between the numbers of excluded and recommended drugs for which we could find no cost-effectiveness evidence...
October 18, 2017: Health Services Research
https://www.readbyqxmd.com/read/29045635/caregiving-spouses-and-the-experience-of-involuntary-separation
#4
Willow C Glasier, Kelly J Arbeau
Background and Objectives: We explored the meaning of the experience of involuntary separation, as defined formally by the Canadian government and informally by our participants, in formerly caregiving spouses whose partners had been admitted to long-term care. Our goal was to explore their lifeworld experience of separation, including factors influencing well-being as spouses shifted from at-home caregiving to involuntary separation. Research Design and Methods: Guided, semi-scripted personal interviews were conducted with 10 individuals who had become involuntarily separated up to 4 years prior to the interview...
October 13, 2017: Gerontologist
https://www.readbyqxmd.com/read/29037171/peakcaller-an-automated-graphical-interface-for-the-quantification-of-intracellular-calcium-obtained-by-high-content-screening
#5
Elena Artimovich, Russell K Jackson, Michaela B C Kilander, Yu-Chih Lin, Michael W Nestor
BACKGROUND: Intracellular calcium is an important ion involved in the regulation and modulation of many neuronal functions. From regulating cell cycle and proliferation to initiating signaling cascades and regulating presynaptic neurotransmitter release, the concentration and timing of calcium activity governs the function and fate of neurons. Changes in calcium transients can be used in high-throughput screening applications as a basic measure of neuronal maturity, especially in developing or immature neuronal cultures derived from stem cells...
October 16, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/29036584/cgheliparm-analysis-of-dsdna-helical-parameters-for-coarse-grained-martini-molecular-dynamics-simulations
#6
Ignacio Faustino, S J Marrink
Summary: We introduce cgHeliParm, a python program that provides the conformational analysis of Martini-based coarse-grained double strand DNA molecules. The software calculates the helical parameters such as base, base pair and base pair step parameters. cgHeliParm can be used for the analysis of coarse grain Martini molecular dynamics trajectories without transformation into atomistic models. Availability and implementation: This package works with Python 2.7 on MacOS and Linux...
July 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036557/standardizing-biomass-reactions-and-ensuring-complete-mass-balance-in-genome-scale-metabolic-models
#7
Siu H J Chan, Jingyi Cai, Lin Wang, Margaret N Simons-Senftle, Costas D Maranas
Motivation: In a genome-scale metabolic model, the biomass produced is defined to have a molecular weight (MW) of 1 g mmol -1 . This is critical for correctly predicting growth yields, contrasting multiple models and more importantly modeling microbial communities. However, the standard is rarely verified in the current practice and the chemical formulae of biomass components such as proteins, nucleic acids and lipids are often represented by undefined side groups (e.g. X, R). Results: We introduced a systematic procedure for checking the biomass weight and ensuring complete mass balance of a model...
July 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036497/forecasting-residue-residue-contact-prediction-accuracy
#8
P P Wozniak, B M Konopka, J Xu, G Vriend, M Kotulska
Motivation: Apart from meta-predictors, most of today's methods for residue-residue contact prediction are based entirely on Direct Coupling Analysis (DCA) of correlated mutations in multiple sequence alignments (MSAs). These methods are on average ∼40% correct for the 100 strongest predicted contacts in each protein. The end-user who works on a single protein of interest will not know if predictions are either much more or much less correct than 40%, which is especially a problem if contacts are predicted to steer experimental research on that protein...
June 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29035079/action-and-perception-in-literacy-a-common-code-for-spelling-and-reading
#9
George Houghton
There is strong evidence that reading and spelling in alphabetical scripts depend on a shared representation (common-coding). However, computational models usually treat the two skills separately, producing a wide variety of proposals as to how the identity and position of letters is represented. This article treats reading and spelling in terms of the common-coding hypothesis for perception-action coupling. Empirical evidence for common representations in spelling-reading is reviewed. A novel version of the Start-End Competitive Queuing (SE-CQ) spelling model is introduced, and tested against the distribution of positional errors in Letter Position Dysgraphia, data from intralist intrusion errors in spelling to dictation, and dysgraphia because of nonperipheral neglect...
October 16, 2017: Psychological Review
https://www.readbyqxmd.com/read/29034486/-everyone-assumes-a-man-to-be-quite-strong-men-masculinity-and-rheumatoid-arthritis-a-case-study-approach
#10
Caroline Flurey, Alan White, Karen Rodham, John Kirwan, Robert Noddings, Sarah Hewlett
Current literature has overlooked the impact of chronic illness on masculine identity. We therefore aimed to investigate the impact of rheumatoid arthritis (a long term condition, affecting more women than men) on masculine identity. Six focus groups with 22 men with rheumatoid arthritis (RA) (data reported elsewhere) followed by five one-to-one interviews with men (English, mean age: 59 years) sampled to reflect a heterogeneous experience of life with RA based on knowledge gained from the focus groups. Transcripts were analysed using thematic analysis and are presented as individual case studies...
October 15, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29032870/insurance-status-and-access-to-urgent-primary-care-follow-up-after-an-emergency-department%C3%A2-visit-in-2016
#11
Shih-Chuan Chou, Yanhong Deng, Jerry Smart, Vivek Parwani, Steven L Bernstein, Arjun K Venkatesh
STUDY OBJECTIVE: We examine the availability of follow-up appointments for emergency department (ED) patients without established primary care by insurance and clinical condition. METHODS: We used "secret shopper" methodology, employing 2 black men to telephone all 53 primary care practices in greater New Haven, posing as new patients discharged from the ED and requesting follow-up appointments. Each practice received 6 scripted calls from each caller during an 8-month period, reflecting all possible scenarios based on 3 insurance types (Medicaid, state exchange, and commercial) and 2 conditions (hypertension and back pain)...
October 4, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29028963/zcchc17-is-a-master-regulator-of-synaptic-gene-expression-in-alzheimer-s-disease
#12
Zeljko Tomljanovic, Mitesh Patel, William Shin, Andrea Califano, Andrew F Teich
Motivation: In an effort to better understand the molecular drivers of synaptic and neurophysiologic dysfunction in Alzheimer's disease (AD), we analyzed neuronal gene expression data from human AD brain tissue to identify master regulators of synaptic gene expression. Results: Master regulator analysis identifies ZCCHC17 as normally supporting the expression of a network of synaptic genes, and predicts that ZCCHC17 dysfunction in AD leads to lower expression of these genes...
September 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028889/segway-2-0-gaussian-mixture-models-and-minibatch-training
#13
Rachel C W Chan, Maxwell W Libbrecht, Eric G Roberts, Jeffrey A Bilmes, William Stafford Noble, Michael M Hoffman
Summary: Segway performs semi-automated genome annotation, discovering joint patterns across multiple genomic signal datasets. We discuss a major new version of Segway and highlight its ability to model data with substantially greater accuracy. Major enhancements in Segway 2.0 include the ability to model data with a mixture of Gaussians, enabling capture of arbitrarily complex signal distributions, and minibatch training, leading to better learned parameters. Availability and Implementation: Segway and its source code are freely available for download at http://segway...
September 22, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028265/stereogene-rapid-estimation-of-genome-wide-correlation-of-continuous-or-interval-feature-data
#14
Elena D Stavrovskaya, Tejasvi Niranjan, Elana J Fertig, Sarah J Wheelan, Alexander V Favorov, Andrey A Mironov
Motivation: Genomics features with similar genome-wide distributions are generally hypothesized to be functionally related, for example, colocalization of histones and transcription start sites indicate chromatin regulation of transcription factor activity. Therefore, statistical algorithms to perform spatial, genome-wide correlation among genomic features are required. Results: Here, we propose a method, StereoGene, that rapidly estimates genome-wide correlation among pairs of genomic features...
October 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29027042/-sex-in-a-relationship-versus-sex-during-a-one-night-stand-the-link-between-mental-representations-of-consensual-sexuality-mating-strategies-and-sexual-experience-in-heterosexual-women-and-men
#15
Steffen Landgraf, Isabella von Treskow, Michael Osterheider
Sexual scripts, that is, the mental representations of sexual behavior, are highly influenced by mating strategies and sexual experience. The relationship between these factors and sexual scripts is, however, poorly understood. Therefore, we assessed how long-term (e.g., "sex in a relationship") and short-term (e.g., "one-night stand") strategies, as well as experience with highly scripted sexual practices (BDSM: bondage-discipline, dominance-submission, sadism-masochism), influence verbalized sexual script composition and detailedness...
October 12, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29023934/spontaneous-emergence-of-legibility-in-writing-systems-the-case-of-orientation-anisotropy
#16
Olivier Morin
Cultural forms are constrained by cognitive biases, and writing is thought to have evolved to fit basic visual preferences, but little is known about the history and mechanisms of that evolution. Cognitive constraints have been documented for the topology of script features, but not for their orientation. Orientation anisotropy in human vision, as revealed by the oblique effect, suggests that cardinal (vertical and horizontal) orientations, being easier to process, should be overrepresented in letters. As this study of 116 scripts shows, the orientation of strokes inside written characters massively favors cardinal directions, and it is organized in such a way as to make letter recognition easier: Cardinal and oblique strokes tend not to mix, and mirror symmetry is anisotropic, favoring vertical over horizontal symmetry...
October 10, 2017: Cognitive Science
https://www.readbyqxmd.com/read/29021608/amyloidogenic-motifs-revealed-by-n-gram-analysis
#17
Michał Burdukiewicz, Piotr Sobczyk, Stefan Rödiger, Anna Duda-Madej, Paweł Mackiewicz, Małgorzata Kotulska
Amyloids are proteins associated with several clinical disorders, including Alzheimer's, and Creutzfeldt-Jakob's. Despite their diversity, all amyloid proteins can undergo aggregation initiated by short segments called hot spots. To find the patterns defining the hot spots, we trained predictors of amyloidogenicity, using n-grams and random forest classifiers. Since the amyloidogenicity may not depend on the exact sequence of amino acids but on their more general properties, we tested 524,284 reduced amino acid alphabets of different lengths (three to six letters) to find the alphabet providing the best performance in cross-validation...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29019297/reducing-potentially-inappropriate-prescribing-for-older-people-in-primary-care-cost-effectiveness-of-the-opti-script-intervention
#18
Paddy Gillespie, Barbara Clyne, Adam Raymakers, Tom Fahey, Carmel M Hughes, Susan M Smith
OBJECTIVES: This study examines the cost-effectiveness of the OPTI-SCRIPT intervention on potentially inappropriate prescribing in primary care. METHODS: Economic evaluation, using incremental cost-effectiveness and cost utility analyses, conducted alongside a cluster randomized controlled trial of twenty-one general practices and 196 patients, to compare a multifaceted intervention with usual practice in primary care in Ireland. Potentially inappropriate prescriptions (PIPs) were determined by a pharmacist...
October 11, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29018588/do-chain-pharmacies-perform-better-than-independent-pharmacies-evidence-from-a-standardised-patient-study-of-the-management-of-childhood-diarrhoea-and-suspected-tuberculosis-in-urban-india
#19
Rosalind Miller, Catherine Goodman
INTRODUCTION: Pharmacies and drug stores are frequently patients' first point of care in many low-income and middle-income countries, but their practice is often poor. Pharmacy retailing in India has traditionally been dominated by local, individually owned shops, but recent years have seen the growth of pharmacy chains. In theory, lower-powered profit incentives and self-regulation to preserve brand identity may lead to higher quality in chain stores. In practice, this has been little studied...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29016696/a-battery-less-and-wireless-wearable-sensor-system-for-identifying-bed-and-chair-exits-in-a-pilot-trial-in-hospitalized-older-people
#20
Roberto L Shinmoto Torres, Renuka Visvanathan, Derek Abbott, Keith D Hill, Damith C Ranasinghe
Falls in hospitals are common, therefore strategies to minimize the impact of these events in older patients and needs to be examined. In this pilot study, we investigate a movement monitoring sensor system for identifying bed and chair exits using a wireless wearable sensor worn by hospitalized older patients. We developed a movement monitoring sensor system that recognizes bed and chair exits. The system consists of a machine learning based activity classifier and a bed and chair exit recognition process based on an activity score function...
2017: PloS One
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