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https://www.readbyqxmd.com/read/29672944/communication-skills-curriculum-scripting-too-soon
#1
Anne Zinski
No abstract text is available yet for this article.
May 2018: Medical Education
https://www.readbyqxmd.com/read/29671130/heterosexual-college-students-who-hookup-with-same-sex-partners
#2
Arielle Kuperberg, Alicia M Walker
Individuals who identify as heterosexual but engage in same-sex sexual behavior fascinate both researchers and the media. We analyzed the Online College Social Life Survey dataset of over 24,000 undergraduate students to examine students whose last hookup was with a same-sex partner (N = 383 men and 312 women). The characteristics of a significant minority of these students (12% of men and 25% of women) who labelled their sexual orientation "heterosexual" differed from those who self-identified as "homosexual," "bisexual," or "uncertain...
April 18, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29670317/-the-heart-desires-but-the-body-refuses-sexual-scripts-older-men-s-perceptions-of-sexuality-and-implications-for-their-mental-and-sexual-health
#3
Sylivia Karen Rutagumirwa, Ajay Bailey
We use sexual scripting theory in the present paper to gain a better understanding of older men's perceptions of their sexuality in relation to dominant Tanzanian cultural norms of masculinity. Qualitative in-depth interviews were conducted with 15 older men, and ten focus group discussions were conducted with 60 men aged 60-82. Participants' recruitment was guided by theoretical sampling strategies. Consistent with the principles of grounded theory, data collection and analysis occurred simultaneously. Our findings indicate that Jando (male initiation rites) serves as a script for male sexuality that outlines the expectations and rewards of male sexuality...
2018: Sex Roles
https://www.readbyqxmd.com/read/29667694/a-grounded-theory-investigation-into-sophomore-students-recall-of-depression-during-their-freshman-year-in-college-a-pilot-study
#4
Julie M Brandy, Theresa A Kessler, Christina H Grabarek
Using a grounded theory approach, the current descriptive qualitative design was conducted with sophomore students to understand the meaning participants gave their freshman experiences with depression. Twelve participants were recruited using scripted class announcements across campus. After informed consent, interviews began with the question: What was the experience of your freshman year in college? All interviews were completed with the primary investigator and transcribed verbatim. Interviews were analyzed using constant comparative methodology...
April 17, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29667314/the-diary-of-a-nonagenarian-centenarian-woman-with-dementia-memory-loss-life-changes-and-community-care-in-japan
#5
Sayuri Suwa, Saori Otani, Mayuko Tsujimura, Kotoko Nogawa, Yoko Shiya
AIM: This study aimed to explore the experiences and thoughts of a nonagenarian-centenarian woman with dementia living alone, through detailed analysis of her unsolicited diary. DATA SOURCE: After receiving consent from Aki (a pseudonym), her family and caregivers, copies of her diaries, hand-written in Japanese, were provided for analysis. METHODS: The content of the diaries was broadly organized into themes and qualitative content analysis carried out for each theme along a sequential timeline...
April 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29666043/mobile-app-usage-patterns-of-patients-prescribed-a-smoking-cessation-medicine-prospective-observational-study
#6
Marianna Bruno, Marcia Wright, Christine L Baker, Birol Emir, Eric Carda, Michelle Clausen, Catherine Sigler, Aanal Patel
BACKGROUND: Cigarette smoking is the leading preventable cause of death and is responsible for more than 480,000 deaths per year in the United States. Smoking cessation is challenging for many patients. Regardless of available treatment options, most quit attempts are unaided, and it takes multiple attempts before a patient is successful. With the ever-increasing use of smartphones, mobile apps hold promise in supporting cessation efforts. This study evaluates the ease of use and user satisfaction with the Pfizer Meds app to support smoking cessation among patients prescribed varenicline (Chantix)...
April 17, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29665295/family-photography-and-persecuted-communities-methodological-challenges
#7
Kirsten Emiko McAllister
This paper examines methodological challenges involved in conducting research on family photographs from persecuted communities, using Japanese Canadian photos as a case study. Approaching family photography as a social practice that instills dominant familial ideologies, the paper examines their "performative scripts" that arrange family members according to normative identities and roles. The paper argues that researchers are not immune to scripts that shape how and what we have been socialized to see (and not see) in family photos...
April 17, 2018: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/29664547/hsd3b2-hsd17b1-hsd17b2-esr1-esr2-and-ar-expression-in-infertile-women-with-endometriosis
#8
Maciej Osiński, Przemysław Wirstlein, Ewa Wender-Ożegowska, Mateusz Mikołajczyk, Paweł Piotr Jagodziński, Małgorzata Szczepańska
OBJECTIVES: The development of endometriosis is associated with changes in the expression of genes encoding the 3β-hydroxysteroid dehydrogenase type II (HSD3B2) and 17β-hydroxysteroid dehydrogenase type II (HSD17B2), estrogen receptors 1 (ESR1) and 2 (ESR2) and the androgen receptor (AR). However, little is known about the expression of HSD3B2, HSD17B1, HSD17B2, ESR1 ESR2 and AR during the endometrial phases in eutopic endometrium from infertile women with endometriosis. MATERIAL AND METHODS: Using RT-qPCR analysis, we assessed the expression of the studied genes in the follicular and luteal phases in eutopic endometrium from fertile women (n = 17) and infertile women (n = 35) with endometriosis...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29664470/curated-compendium-of-human-transcriptional-biomarker-data
#9
Nathan P Golightly, Avery Bell, Anna I Bischoff, Parker D Hollingsworth, Stephen R Piccolo
One important use of genome-wide transcriptional profiles is to identify relationships between transcription levels and patient outcomes. These translational insights can guide the development of biomarkers for clinical application. Data from thousands of translational-biomarker studies have been deposited in public repositories, enabling reuse. However, data-reuse efforts require considerable time and expertise because transcriptional data are generated using heterogeneous profiling technologies, preprocessed using diverse normalization procedures, and annotated in non-standard ways...
April 17, 2018: Scientific Data
https://www.readbyqxmd.com/read/29659514/coronial-practice-indigeneity-and-suicide
#10
Gordon Tait, Belinda Carpenter, Stephanie Jowett
All available data suggest that, like many other Indigenous peoples, Australian Aborigines are significantly more likely to kill themselves than are non-Aboriginal Australians. This statistical disparity is normally positioned an objective, ontological and undeniable social fact, a fact best explained as a function of endemic community disadvantage and disenfranchisement. This research explores the possibility that higher-than-normal Aboriginal suicide rates may also be a function of coronial decision-making practices...
April 16, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29656532/of-lamp-posts-keys-and-fabled-drunkards-a-perspectival-tale-of-4-guidelines
#11
Trisha Greenhalgh
BACKGROUND: Evidence-based medicine is the application of research findings to inform individual clinical decisions. There is a tension-both philosophical and practical-between the average result from a population study and the circumstances and needs of an individual patient. This personal account of "evidence-based" trauma care illustrates and explores this tension. THE CASE: The author, a keen athlete, describes her experience of a high-impact cycle accident that led to limb fractures (which were diagnosed and treated according to evidence-based guidelines) and also an occult injury to the cervical spine (which was not diagnosed at the time)...
April 15, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29655687/the-inhibitory-potential-of-broussochalcone-a-for-the-human-cytochrome-p450-2j2-isoform-and-its-anti-cancer-effects-via-foxo3-activation
#12
See-Hyoung Park, Jongsung Lee, Jong Cheol Shon, Nguyen Minh Phuc, Jun Goo Jee, Kwang-Hyeon Liu
BACKGROUND: Broussonetia papyrifera (L.) Ventenat, a traditional medicinal herb, has been applied as a folk medicine to treat various diseases. Broussochalcone A (BCA), a chalcone compound isolated from the cortex of Broussonetia papyrifera (L.) Ventenat, exhibits several biological activities including potent anti-oxidant, antiplatelet, and cytotoxic effects. PURPOSE: The purpose of this study is to elucidate the inhibitory effect of BCA against CYP2J2 enzyme which is predominantly expressed in human tumor tissues and carcinoma cell lines...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29650076/digital-tools-to-enhance-clinical-reasoning
#13
REVIEW
Reza Manesh, Gurpreet Dhaliwal
Physicians can improve their diagnostic acumen by adopting a simulation-based approach to analyzing published cases. The tight coupling of clinical problems and their solutions affords physicians the opportunity to efficiently upgrade their illness scripts (structured knowledge of a specific disease) and schemas (structured frameworks for common problems). The more times clinicians practice accessing and applying those knowledge structures through published cases, the greater the odds that they will have an enhanced approach to similar patient-cases in the future...
May 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29650016/evolution-of-computational-models-in-biomodels-database-and-the-physiome-model-repository
#14
Martin Scharm, Tom Gebhardt, Vasundra Touré, Andrea Bagnacani, Ali Salehzadeh-Yazdi, Olaf Wolkenhauer, Dagmar Waltemath
BACKGROUND: A useful model is one that is being (re)used. The development of a successful model does not finish with its publication. During reuse, models are being modified, i.e. expanded, corrected, and refined. Even small changes in the encoding of a model can, however, significantly affect its interpretation. Our motivation for the present study is to identify changes in models and make them transparent and traceable. METHODS: We analysed 13734 models from BioModels Database and the Physiome Model Repository...
April 12, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29630045/investigation-of-protein-recruitment-to-dna-lesions-using-405-nm-laser-micro-irradiation
#15
Antoine Gaudreau-Lapierre, Daniel Garneau, Billel Djerir, Frédéric Coulombe, Théo Morin, Alexandre Marechal
The DNA Damage Response (DDR) uses a plethora of proteins to detect, signal, and repair DNA lesions. Delineating this response is critical to understand genome maintenance mechanisms. Since recruitment and exchange of proteins at lesions are highly dynamic, their study requires the ability to generate DNA damage in a rapid and spatially-delimited manner. Here, we describe procedures to locally induce DNA damage in human cells using a commonly available laser-scanning confocal microscope equipped with a 405 nm laser line...
March 20, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29623747/attachment-styles-and-secure-base-priming-in-relation-to-emotional-reactivity-after-frustration-induction
#16
Annemiek Karreman, Ad J J M Vingerhoets, Marrie H J Bekker
In two experimental studies, we explored the role of attachment in predicting emotional reactivity after frustration induction. In the first study, using a cognitive frustration task, we examined in a college sample (N = 134) how attachment styles related to the experience and expression of emotions after frustration induction. In the second study, we investigated in college students (N = 198) the effect of conscious priming of the secure base schema on mood disturbance after the performance of a cognitive frustration task...
April 6, 2018: Cognition & Emotion
https://www.readbyqxmd.com/read/29618286/neuronal-activity-dependent-control-of-postnatal-neurogenesis-and-gliogenesis
#17
Ragnihldur T Káradóttir, Chay T Kuo
The addition of new neurons and oligodendroglia in the postnatal and adult mammalian brain presents distinct forms of gray and white matter plasticity. Substantial effort has been devoted to understanding the cellular and molecular mechanisms controlling postnatal neurogenesis and gliogenesis, revealing important parallels to principles governing the embryonic stages. While during central nervous system development, scripted temporal and spatial patterns of neural and glial progenitor proliferation and differentiation are necessary to create the nervous system architecture, it remains unclear what driving forces maintain and sustain postnatal neural stem cell (NSC) and oligodendrocyte progenitor cell (OPC) production of new neurons and glia...
April 4, 2018: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/29618009/constructing-lightweight-and-flexible-pipelines-using-plugin-based-microbiome-analysis-pluma
#18
Trevor Cickovski, Giri Narasimhan
Motivation: Software pipelines have become almost standardized tools for microbiome analysis. Currently many pipelines are available, often sharing some of the same algorithms as stages. This is largely because each pipeline has its own source language and file formats, making it typically more economical to reinvent the wheel than to learn and interface to an existing package. We present PluMA, or Plugin-Based Microbiome Analysis, which addresses this problem by providing a lightweight back end that can be infinitely extended using dynamically loaded plugin extensions...
March 29, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29617941/a-reference-peptide-database-for-proteome-quantification-based-on-experimental-mass-spectrum-response-curves
#19
Wanlin Liu, Lai Wei, Jianan Sun, Jinwen Feng, Gaigai Guo, Lizhu Liang, Tianyi Fu, Mingwei Liu, Kai Li, Yin Huang, Weimin Zhu, Bei Zhen, Yi Wang, Chen Ding, Jun Qin
Motivation: Mass spectrometry (MS) based quantification of proteins/peptides has become a powerful tool in biological research with high sensitivity and throughput. The accuracy of quantification, however, has been problematic as not all peptides are suitable for quantification. Several methods and tools have been developed to identify peptides that response well in mass spectrometry and they are mainly based on predictive models, and rarely consider the linearity of the response curve, limiting the accuracy and applicability of the methods...
March 30, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29608570/transfer-of-the-left-side-bias-effect-in-perceptual-expertise-the-case-of-simplified-and-traditional-chinese-character-recognition
#20
Tianyin Liu, Su-Ling Yeh, Janet H Hsiao
The left-side bias (LSB) effect observed in face and expert Chinese character perception is suggested to be an expertise marker for visual object recognition. However, in character perception this effect is limited to characters printed in a familiar font (font-sensitive LSB effect). Here we investigated whether the LSB and font-sensitive LSB effects depend on participants' familiarity with global structure or local component information of the stimuli through examining their transfer effects across simplified and traditional Chinese scripts: the two Chinese scripts share similar overall structures but differ in the visual complexity of local components in general...
2018: PloS One
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