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https://www.readbyqxmd.com/read/28075422/inflammation-cardiometabolic-markers-and-functional-changes-in-a-randomized-controlled-trial-of-a-12-month-exercise-program-for-prostate-cancer-men
#1
Katarzyna Hojan, Eliza Kwiatkowska-Borowczyk, Ewa Leporowska, Piotr Milecki
INTRODUCTION    Previous studies have shown that physical exercise in cancer patients during radiotherapy (RT) and androgen deprivation therapy (ADT) improves cardiac fitness and quality of life (QoL), and reduces fatigue but it is still not entirely known how it affects inflammation or metabolic factors and what its consequences are in prostate cancer (PCa) patients. OBJECTIVES    Effect of a 12-month physical exercise program on inflammatory and cardiometabolic factors, and on functional status in PCa patients undergoing RT and ADT...
January 10, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28068243/sentinel-lymph-node-dissection-to-select-clinically-node-negative-prostate-cancer-patients-for-pelvic-radiation-therapy-effect-on-biochemical-recurrence-and-systemic-progression
#2
Nikolaos Grivas, Esther Wit, Floris Pos, Jeroen de Jong, Erik Vegt, Axel Bex, Kees Hendricksen, Simon Horenblas, Gijs KleinJan, Bas van Rhijn, Henk van der Poel
PURPOSE: To assess the efficacy of robotic-assisted laparoscopic sentinel lymph node (SLN) dissection (SLND) to select those patients with prostate cancer (PCa) who would benefit from additional pelvic external beam radiation therapy and long-term androgen deprivation therapy (ADT). METHODS AND MATERIALS: Radioisotope-guided SLND was performed in 224 clinically node-negative patients scheduled to undergo external beam radiation therapy. Patients with histologically positive SLNs (pN1) were also offered radiation therapy to the pelvic lymph nodes, combined with 3 years of ADT...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28067607/hormone-therapy-for-prostate-cancer-increases-the-risk-of-alzheimer-s-disease-a-nationwide-4-year-longitudinal-cohort-study
#3
Jhen-Hao Jhan, Yuan-Han Yang, Yu-Han Chang, Shiao-Jin Guu, Chia-Chun Tsai
INTRODUCTION: Androgen-deprivation therapy (ADT) is recognized to be the preferred first-line treatment for advanced prostate cancer. However, the risk-benefit ratio of ADT remains poorly defined and the relationship between androgen depletion and dementia is not clear. AIM: To investigate the risk of developing Alzheimer's disease (AD) in patients undergoing ADT for prostate cancer. METHODS: Data from 24 360 prostate cancer patients were collected from the Longitudinal Health Insurance Database of Taiwan...
January 9, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28062546/the-clinical-importance-of-quantifying-fat-distribution-during-androgen-deprivation
#4
Stephen John Foulkes, Robin M Daly, Steve Fraser
Androgen deprivation therapy (ADT) is now considered a mainstay in the treatment of metastatic and locally advanced prostate cancer (PCa). Despite well-established benefits of ADT in relation to overall survival, this treatment has been associated with a number of adverse effects, particularly with regard to key cardiometabolic risk factors including the development of insulin resistance, dyslipidaemia and increases in total and regional fat mass. In non-ADT populations, increased levels of visceral adipose tissue (VAT) are thought to be a key mediator of the increased cardiometabolic risk associated with weight gain, but this has received limited attention in men treated with ADT...
January 6, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28061904/classifying-high-risk-versus-very-high-risk-prostate-cancer-is-it-relevant-to-outcomes-of-conformal-radiotherapy-and-androgen-deprivation
#5
Akram Saad, Jeffrey Goldstein, Yaacov R Lawrence, Benjamin Spieler, Raya Leibowitz-Amit, Raanan Berger, Tima Davidson, Damien Urban, Lev Tsang, Dror Alezra, Ilana Weiss, Zvi Symon
OBJECTIVE: To evaluate outcomes in prostate cancer patients classified as high-risk (HR) or very high-risk (VHR) who were treated with conformal radiation therapy (CRT) and androgen deprivation therapy (ADT). METHODS: Between 11/2001 and 3/2012, 203 patients with HR disease received CRT to the prostate (78-82 Gy) and pelvic lymph nodes (46-50 Gy) with ADT (6 m-2 years). Median follow-up was 50 months (12 m-142 m). Biochemical failure was defined according to Phoenix definition...
January 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28055108/impact-of-ethnicity-on-the-outcome-of-men-with-metastatic-hormone-sensitive-prostate-cancer
#6
Brandon Bernard, Vinayak Muralidhar, Yu-Hui Chen, Srikala S Sridhar, Edith P Mitchell, Curtis A Pettaway, Michael A Carducci, Paul L Nguyen, Christopher J Sweeney
BACKGROUND: Prostate cancer (PCa) outcomes are impacted by socioeconomic and biologic factors. Ethnicity plays a role in the former, but little is known about the responsiveness of metastatic PCa to androgen-deprivation therapy (ADT) among races. METHODS: The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify men who were diagnosed with distant, de novo, metastatic PCa from 2004 to 2012. Patterns of presentation, overall survival (OS), and PCa-specific mortality (PCSM) were determined for each race...
January 5, 2017: Cancer
https://www.readbyqxmd.com/read/28052297/androgen-receptor-gene-copy-number-and-protein-expression-in-treatment-na%C3%A3-ve-prostate-cancer
#7
Filip Poelaert, Candy Kumps, Nicolaas Lumen, Stephanie Verschuere, Louis Libbrecht, Marleen Praet, Sylvie Rottey, Tom Claeys, Piet Ost, Karel Decaestecker, Gert De Meerleer, Charles Van Praet
OBJECTIVES: To evaluate the androgen receptor (AR) gene copy number in androgen deprivation therapy (ADT) treatment-naïve prostate cancer (PCa) patients and to evaluate the corresponding AR protein expression and assess the association between these features and prognostic factors. MATERIALS AND METHODS: Chromosome X and AR gene copy number, using fluorescence-in-situ-hybridization, and epithelial-stromal AR expression, using AR immunohistochemistry, were analyzed in 62 ADT treatment-naïve PCa patients and 8 castration-refractory patients...
January 5, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28045496/magnetic-nanoliposomes-as-in-situ-microbubble-bombers-for-multimodality-image-guided-cancer-theranostics
#8
Yang Liu, Fang Yang, Chuxiao Yuan, Mingxi Li, Tuantuan Wang, Bo Chen, Juan Jin, Peng Zhao, Jiayi Tong, Shouhua Luo, Ning Gu
Nano-sized drug delivery systems have offered promising approaches for cancer theranostics. However, few are effective to simultaneously maximize tumor specific uptake, imaging and therapy in a single nanoplatform. Here, we report a simple yet stimuli-responsive anethole dithiolethione (ADT) loaded magnetic nanoliposomes (AMLs) delivery system, which consists of ADT, hydrogen sulfide (H2S) pro-drug, doped in the lipid bilayer, and superparamagnetic nanoparticles (MNPs) encapsulated inside. HepG2 cells could be effectively bombed after 6 h co-incubation with AMLs...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28045114/treatment-of-m1a-m1b-prostate-cancer-with-or-without-radical-prostatectomy-at-diagnosis
#9
M Moschini, A Morlacco, E Kwon, L J Rangel, R J Karnes
BACKGROUND: The aim of the study was to evaluate survival and perioperative outcomes of metastatic prostate cancer (mPCa) patients treated with surgery or androgen deprivation treatment (ADT) only. METHODS: We retrospectively selected 47 metastatic PCa patients treated at a single center (Mayo Clinic, Rochester, MN) by two urologists (RJK and EK) between 2007 and 2014. Overall, 31 (66%) underwent radical prostatectomy (RP) with or without adjuvant therapies and 16 (34%) underwent ADT only...
January 3, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28043947/five-year-quality-of-life-assessment-after-carbon-ion-radiotherapy-for-prostate-cancer
#10
Katsuya Maruyama, Hiroshi Tsuji, Takuma Nomiya, Hiroyuki Katoh, Hitoshi Ishikawa, Tadashi Kamada, Masaru Wakatsuki, Koichiro Akakura, Jun Shimazaki, Hidefumi Aoyama, Hirohiko Tsujii
The aim of this study was to prospectively assess 5-year health-related quality of life (HRQOL) of patients treated with carbon ion radiotherapy (C-ion RT) for clinically localized prostate cancer. A total of 417 patients received carbon ion radiotherapy at a total dose of 63-66 Gray-equivalents (GyE) in 20 fractions over 5 weeks, and neoadjuvant and adjuvant androgen deprivation therapy (ADT) were administered for intermediate and high-risk patients. A HRQOL assessment was performed at five time points (immediately before the initiation of C-ion RT, immediately after, and at 12, 36 and 60 months after completion of C-ion RT) using Functional Assessment of Cancer Therapy (FACT) questionnaires...
January 1, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28043112/the-influence-of-androgen-deprivation-therapy-on-prostate-size-and-voiding-symptoms-in-prostate-cancer-patients-in-korea
#11
Hoon Choi, Hong Chung, Jae Young Park, Jeong Gu Lee, Jae Hyun Bae
PURPOSE: The goal of this study is to investigate the effects of androgen deprivation therapy (ADT) on total prostate volume and lower urinary tract symptoms (LUTS). METHODS: Between January 2007 and June 2014, 110 patients who received androgen deprivation treatment were enrolled in this retrospective study. Clinical parameters and urodynamic parameters along with changes at follow-up were analyzed. Factors such as reduction in prostate volume, changes in LUTS, and prostate volume tertiles were compared 1 year after ADT...
December 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/28039695/docetaxel-in-the-treatment-of-castrate-resistant-advanced-prostate-cancer-a-paradigm-in-change
#12
Mircea Dediu, Florentina Bratu, Mihaela Amarandei, Eniko Fejer
Until last year, the international guidelines recommended the use of docetaxel in advanced prostate cancer (PC) at the time of progression following androgen deprivation therapy (ADT). Nevertheless, two randomized phase III trials, CHAARTED and STAMPEDE, delivered level I evidence showing that upfront introduction of docetaxel, during the androgen sensitive course of disease, is able to significantly improve the patients' overall survival. As such, this strategy was rapidly included in the current guideline recommendations, with slightly different indications in the ESMO as compared to the NCCN version...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28036278/a-novel-nonsense-mutation-in-androgen-receptor-confers-resistance-to-cyp17-inhibitor-treatment-in-prostate-cancer
#13
Dong Han, Shuai Gao, Kevin Valencia, Jude Owiredu, Wanting Han, Eric de Waal, Jill A Macoska, Changmeng Cai
The standard treatment for prostate cancer (PCa) is androgen deprivation therapy (ADT) that blocks transcriptional activity of androgen receptor (AR). However, ADT invariably leads to the development of castration-resistant PCa (CRPC) with restored activity of AR. CRPC can be further treated with CYP17 inhibitors to block androgen synthesis pathways, but most patients still relapse after a year of such treatment. The mechanisms that drive this progression are not fully understood, but AR activity, at least in a subset of cancers, appears to be restored again...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28029404/a-combined-single-high-dose-rate-brachytherapy-boost-with-hypofractionated-external-beam-radiotherapy-results-in-a-high-rate-of-biochemical-disease-free-survival-in-localised-intermediate-and-high-risk-prostate-cancer-patients
#14
Nuradh Joseph, Cathy Taylor, Catherine O'Hara, Ananya Choudhury, Tony Elliott, John Logue, James Wylie
INTRODUCTION: Dose escalation has been shown to improve biochemical outcome in localised prostate cancer. An HDR brachytherapy boost is an effective strategy for dose escalation, since it exploits the low α/β ratio in prostate cancer, allowing the delivery of a high biological dose to the tumour. We sought to evaluate the biochemical disease free survival in patients with intermediate and high risk localised prostate cancer treated with EBRT plus HDR brachytherapy as a boost, in our institution...
October 28, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28028737/efficacy-of-testosterone-suppression-with-sustained-release-triptorelin-in-advanced-prostate-cancer
#15
Jürgen Breul, Eija Lundström, Daniela Purcea, Werner P Venetz, Patrick Cabri, Pascale Dutailly, Evan R Goldfischer
INTRODUCTION: Androgen deprivation therapy (ADT) is a mainstay of treatment against advanced prostate cancer (PC). As a treatment goal, suppression of plasma testosterone levels to <50 ng/dl has been established over decades. Evidence is growing though that suppression to even lower levels may add further clinical benefit. Therefore, we undertook a pooled retrospective analysis on the efficacy of 1-, 3-, and 6-month sustained-release (SR) formulations of the gonadotropin-releasing hormone (GnRH) agonist triptorelin to suppress serum testosterone concentrations beyond current standards...
December 27, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/28028164/thermoperiodic-control-of-floral-induction-involves-modulation-of-the-diurnal-flowering-locus-t-expression-pattern
#16
Micael Wendell, Linda Ripel, YeonKyeong Lee, Odd Arne Rognli, Sissel Torre, Jorunn E Olsen
Thermoperiodism is defined as the ability to discriminate between day (DT) and night temperature (NT). Our aim was to shed light on the mechanistic basis of thermoperiodic floral induction with acceleration under lower DT than NT compared to other DT-NT-combinations at the same average daily temperature (ADT), a response exploited in temperate area greenhouses. Arabidopsis thaliana floral pathway mutants and a lhy circadian clock mutant as well as the expression of floral integrators and LHY were studied under different DT-NT-combinations, all at the same ADT...
December 27, 2016: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28018903/impact-of-lymph-node-burden-on-survival-of-high-risk-prostate-cancer-patients-following-radical-prostatectomy-and-pelvic-lymph-node-dissection
#17
Lisa Moris, Thomas Van den Broeck, Lorenzo Tosco, Anthony Van Baelen, Paolo Gontero, Robert Jeffrey Karnes, Wouter Everaerts, Maarten Albersen, Patrick J Bastian, Piotr Chlosta, Frank Claessens, Felix K Chun, Markus Graefen, Christian Gratzke, Burkhard Kneitz, Giansilvio Marchioro, Rafael Sanchez Salas, Bertrand Tombal, Henk Van Der Poel, Jochen Christoph Walz, Gert De Meerleer, Alberto Bossi, Karin Haustermans, Francesco Montorsi, Hendrik Van Poppel, Martin Spahn, Alberto Briganti, Steven Joniau
AIM: To determine the impact of the extent of lymph node invasion (LNI) on long-term oncological outcomes after radical prostatectomy (RP). MATERIAL AND METHODS: In this retrospective study, we examined the data of 1,249 high-risk, non-metastatic PCa patients treated with RP and pelvic lymph node dissection (PLND) between 1989 and 2011 at eight different tertiary institutions. We fitted univariate and multivariate Cox models to assess independent predictors of cancer-specific survival (CSS) and overall survival (OS)...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/28011219/in-silico-selection-and-cell-based-characterization-of-selective-and-bioactive-compounds-for-androgen-dependent-prostate-cancer-cell
#18
Elisa C Santa Cruz, Adriel R Carecho, Marta E Saidel, Carlos Alberto Montanari, Andrei Leitão
Prostate cancer is one of the most prevalent types of cancer in male population. It is a hormone driven disease, especially in its initial phase. Hence, androgen deprivation therapy (ADT) is the major chemotherapeutic effort and novel AR inhibitors with improved pharmacological profiles are needed. In this report, a novel bioactive compound was selected and investigated using in silico and cell-based assays. Neq0502 compound was selective for the testosterone stimulated AR-dependent prostate cancer cell (LNCaP, GI50=22...
December 11, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28007137/hotballoon-ablation-of-the-pulmonary%C3%A2-veins-for-paroxysmal-af-a-multicenter-randomized-trial-in-japan
#19
Hiroshi Sohara, Tohru Ohe, Ken Okumura, Shigeto Naito, Kenzo Hirao, Morio Shoda, Youichi Kobayashi, Yasuteru Yamauchi, Yoshio Yamaguchi, Taishi Kuwahara, Haruo Hirayama, Chun YeongHwa, Kengo Kusano, Kazuaki Kaitani, Kimikazu Banba, Satoki Fujii, Koichiro Kumagai, Hisashi Yoshida, Masashi Matsushita, Shutaro Satake, Kazutaka Aonuma
BACKGROUND: Point-by-point catheter ablation is an established treatment for drug-refractory paroxysmal atrial fibrillation (PAF). However, it is time consuming, requires excellent technique to achieve complete pulmonary vein (PV) isolation, and is associated with severe complications. OBJECTIVES: The purpose of this study was to evaluate the safety and effectiveness of a HotBalloon ablation (HBA) compared with antiarrhythmic drug therapy (ADT) for the treatment of PAF...
December 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28004824/high-performing-solution-coated-electrolyte-gated-organic-field-effect-transistors-for-aqueous-media-operation
#20
Qiaoming Zhang, Francesca Leonardi, Stefano Casalini, Inés Temiño, Marta Mas-Torrent
Since the first demonstration, the electrolyte-gated organic field-effect transistors (EGOFETs) have immediately gained much attention for the development of cutting-edge technology and they are expected to have a strong impact in the field of (bio-)sensors. However EGOFETs directly expose their active material towards the aqueous media, hence a limited library of organic semiconductors is actually suitable. By using two mostly unexplored strategies in EGOFETs such as blended materials together with a printing technique, we have successfully widened this library...
December 22, 2016: Scientific Reports
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