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Pneumonia in utero

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https://www.readbyqxmd.com/read/27325071/a-systematic-review-of-children-s-environmental-health-in-brazil
#1
REVIEW
Carmen I R Froes Asmus, Volney M Camara, Philip J Landrigan, Luz Claudio
In the region of the Americas, approximately 100,000 children under the age of 5 years die each year due to environmental hazards. Brazil, due to its large size and wide range of environmental challenges, presents numerous hazards to children's health. The aim of this study was to systematically review the scientific literature that describes children's exposures to environmental pollutants in Brazil and their effects on Brazilian children's health. A systematic review of the scientific literature was performed without language restrictions and time of publication (years)...
January 2016: Annals of Global Health
https://www.readbyqxmd.com/read/27068499/fetal-distress-and-in-utero-pneumonia-in-perinatal-dolphins-during-the-northern-gulf-of-mexico-unusual-mortality-event
#2
Kathleen M Colegrove, Stephanie Venn-Watson, Jenny Litz, Michael J Kinsel, Karen A Terio, Erin Fougeres, Ruth Ewing, D Ann Pabst, William A McLellan, Stephen Raverty, Jeremiah Saliki, Spencer Fire, Gina Rappucci, Sabrina Bowen-Stevens, Lauren Noble, Alex Costidis, Michelle Barbieri, Cara Field, Suzanne Smith, Ruth H Carmichael, Connie Chevis, Wendy Hatchett, Delphine Shannon, Mandy Tumlin, Gretchen Lovewell, Wayne McFee, Teresa K Rowles
An unusual mortality event (UME) involving primarily common bottlenose dolphins Tursiops truncatus of all size classes stranding along coastal Louisiana, Mississippi, and Alabama, USA, started in early 2010 and continued into 2014. During this northern Gulf of Mexico UME, a distinct cluster of perinatal dolphins (total body length <115 cm) stranded in Mississippi and Alabama during 2011. The proportion of annual dolphin strandings that were perinates between 2009 and 2013 were compared to baseline strandings (2000-2005)...
April 12, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/26681042/deep-sequencing-based-analysis-of-gene-expression-in-bovine-mammary-epithelial-cells-after-staphylococcus-aureus-escherichia-coli-and-klebsiella-pneumoniae-infection
#3
L Xiu, Y B Fu, Y Deng, X J Shi, Z Y Bian, A Ruhan, X Wang
The goal of this study was to characterize the transcriptome of primary bovine mammalian epithelial cells (pBMECs) and to identify candidate genes for response and resistance to Staphylococcus aureus (strain S108), Escherichia coli (strain E23), and Klebsiella pneumoniae (strain K96) infection. Using Solexa sequencing, approximately 4.9 million total sequence tags were obtained from each of the three infected libraries and the control library. Gene Ontology (GO) analysis of the S108-infected pBMECs showed differentially expressed genes (DEGs) were significantly involved in metabolic processes...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25987539/maternally-acquired-igg-immunity-in-neonates-born-to-renal-transplanted-women
#4
Patrícia Oliveira Viana, Erika Ono, Maria Isabel Saraiva Dinelli, Beatriz Tavares Costa-Carvalho, Amélia Miyashiro Nunes Dos Santos, Nelson Sass, Maria Isabel de Moraes-Pinto
Neonates born to renal transplanted women are exposed in utero to immunosuppressors and to antenatal conditions that may predispose the neonate to a high risk of prematurity and intrauterine growth retardation. These factors might interfere with the transfer of maternal IgG immunity. Total IgG levels and specific antibodies to measles, varicella, tetanus, Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae (serotypes 4,6B,9V,14,18C,19F and 23F) were evaluated on maternal and cord blood samples of 23 sets of renal transplanted women and their newborns and 32 sets of healthy women-newborns at term...
June 17, 2015: Vaccine
https://www.readbyqxmd.com/read/25754313/-spanish-society-for-pediatric-infectious-diseases-guidelines-on-tuberculosis-in-pregnant-women-and-neonates-i-epidemiology-and-diagnosis-congenital-tuberculosis
#5
F Baquero-Artigao, M J Mellado Peña, T Del Rosal Rabes, A Noguera Julián, A Goncé Mellgren, M de la Calle Fernández-Miranda, M L Navarro Gómez
Tuberculosis (TB) screening in pregnancy using tuberculin skin test (TST) is recommended in case of symptoms of TB disease, close contact with a patient with infectious TB, or high risk of developing active disease. The new interferon gamma release assay (IGRA) tests are recommended in BCG-vaccinated pregnant women with positive TST and no known risk factors for TB, and in those immunocompromised, with clinical suspicion of TB but negative TST. TB diagnosis is difficult due to the non-specific symptoms, the increased frequency of extrapulmonary disease, the delay in radiological examinations, and the high rate of tuberculin anergy...
October 2015: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/25444821/maternal-immunization-with-pneumococcal-9-valent-conjugate-vaccine-and-early-infant-otitis-media
#6
RANDOMIZED CONTROLLED TRIAL
Kathleen A Daly, G Scott Giebink, Bruce R Lindgren, JoAnn Knox, Betty Jo Haggerty, James Nordin, Sarah Goetz, Patricia Ferrieri
A randomized trial of an investigational 9-valent pneumococcal conjugate vaccine (PCV-9) or placebo given to pregnant women during the last trimester to prevent early infant otitis media (OM) was conducted. All infants received Prevnar(®) at 2, 4, 6, and 12 months. Clinic and adverse event records were reviewed to identify OM. Variables significantly related to acute OM by age 6 months (p<0.05) were: vaccine group (9 valent or placebo), sibling history of tympanostomy tubes, upper respiratory infection, and number of clinic visits by 6 months...
December 5, 2014: Vaccine
https://www.readbyqxmd.com/read/25390763/coinfection-and-vertical-transmission-of-brucella-and-morbillivirus-in-a-neonatal-sperm-whale-physeter-macrocephalus-in-hawaii-usa
#7
Kristi L West, Gregg Levine, Jessica Jacob, Brenda Jensen, Susan Sanchez, Kathleen Colegrove, David Rotstein
The viral genus Morbillivirus and the bacterial genus Brucella have emerged as important groups of pathogens that are known to affect cetacean health on a global scale, but neither pathogen has previously been reported from endangered sperm whales (Physeter macrocephalus). A female neonate sperm whale stranded alive and died near Laie on the island of Oahu, Hawaii, US, in May of 2011. Congestion of the cerebrum and enlarged lymph nodes were noted on the gross necropsy. Microscopic findings included lymphoid depletion, chronic meningitis, and pneumonia, suggesting an in utero infection...
January 2015: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/25306604/-variants-of-pathomorphological-changes-in-the-thymus-of-in-utero-infected-extremely-low-birth-weight-neonatal-infants
#8
L V Kulida, L P Peretiatko, S B Nazarov
OBJECTIVE: To analyze pathomorphological changes in the thymus of extremely low birth weight (ELBW) neonatal infants who have developed in the presence of in utero infection. SUBJECTS AND METHODS: A study group included 105 ELBW neonates who had developed in the presence of in utero infection. The main causes of their death were the following conditions: generalized viral and bacterial infection of mixed genesis (n = 56 (53.3%)), congenital pneumonia (n = 27 (25...
May 2014: Arkhiv Patologii
https://www.readbyqxmd.com/read/25031933/pregnancy-in-a-patient-with-cancer-and-heart-failure-challenges-and-complexities
#9
Anecita P Fadol, Tara Lech, Courtney Bickford, Syed Wamique Yusuf
A 24-year-old African American female (L.R.) with a history of smoking and gestational diabetes was diagnosed with Hodgkin lymphoma. She received multiple chemotherapies, including six cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), followed by radiation therapy to left inguinal areas for a total of 30.6 Gy in 17 fractions; she obtained complete remission. Two years later, L.R. had disease relapse in the mediastinum and received two cycles of ESHAP (etoposide, methylprednisolone, high-dose cytarabine, cisplatin) followed by etoposide and ifosfamide...
March 2012: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/24847698/perinatal-bisphenol-a-exposure-beginning-before-gestation-enhances-allergen-sensitization-but-not-pulmonary-inflammation-in-adult-mice
#10
E O'Brien, I L Bergin, D C Dolinoy, Z Zaslona, R J A Little, Y Tao, M Peters-Golden, P Mancuso
Bisphenol A (BPA), a monomer of polycarbonate plastics and epoxide resin, is a high-production-volume chemical implicated in asthma pathogenesis when exposure occurs to the developing fetus. However, few studies have directly examined the effect of in utero and early-life BPA exposure on the pathogenesis of asthma in adulthood. This study examines the influence of perinatal BPA exposure through maternal diet on allergen sensitization and pulmonary inflammation in adult offspring. Two weeks before mating, BALB/c dams were randomly assigned to a control diet or diets containing 50 ng, 50 μg or 50 mg BPA/kg of rodent chow...
April 2014: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/23158015/neonatal-outcome-of-preterm-infants-born-to-mothers-with-abnormal-genital-tract-colonisation-and-chorioamnionitis-a-cohort-study
#11
Joanna P Seliga-Siwecka, Maria K Kornacka
PURPOSE: We hypothesised that abnormal genital tract colonisation leading to an in utero inflammation/infection process, contributes to the risk of respiratory distress syndrome (RDS), patent ductus arteriosus (PDA), intra ventricular haemorrhage (IVH), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC) in preterm infants. METHODS: 396 placentas and umbilical cords of neonates born at 22-32weeks of gestation were evaluated...
May 2013: Early Human Development
https://www.readbyqxmd.com/read/23012868/-a-case-of-spinal-muscular-atrophy-type-0-in-japan
#12
Kentaro Okamoto, Kayoko Saito, Takatoshi Sato, Keiko Ishigaki, Makoto Funatsuka, Makiko Osawa
The patient was a 2-month-old female infant born at 41 weeks and 2 days of gestation presenting multiple arthrogryposis, severe muscle hypotonia and respiratory distress with difficulty in feeding. She suffered from repeated complications with aspiration pneumonia. On admission to our hospital, she exhibited fasciculation and absence of deep tendon reflexes. Examination of the motor nerve conduction velocity (MCV) revealed no muscle contraction. Deletions of the SMN and NAIP genes were noted. Based on severe clinical course and disease development in utero, she was given a diagnosis of spinal muscular atrophy (SMA) type 0 (very severe type)...
September 2012: No to Hattatsu. Brain and Development
https://www.readbyqxmd.com/read/22973041/impaired-surfactant-production-by-alveolar-epithelial-cells-in-a-scid-hu-lung-mouse-model-of-congenital-human-cytomegalovirus-infection
#13
Ekaterina Maidji, Galina Kosikova, Pheroze Joshi, Cheryl A Stoddart
Human cytomegalovirus (HCMV) is the leading viral cause of birth defects and life-threatening lung-associated diseases in premature infants and immunocompromised children. Although the fetal lung is a major target organ of the virus, HCMV lung pathogenesis has remained unexplored, possibly as a result of extreme host range restriction. To overcome this hurdle, we generated a SCID-hu lung mouse model that closely recapitulates the discrete stages of human lung development in utero. Human fetal lung tissue was implanted into severe combined immunodeficient (CB17-scid) mice and inoculated by direct injection with the VR1814 clinical isolate of HCMV...
December 2012: Journal of Virology
https://www.readbyqxmd.com/read/22858279/management-of-giant-congenital-pulmonary-airway-malformations-requiring-pneumonectomy
#14
Offir Ben-Ishay, Grace A Nicksa, Jay M Wilson, Terry L Buchmiller
BACKGROUND: Congenital pulmonary airway malformation (CPAM) is a rare congenital anomaly that occurs sporadically throughout fetal development. CPAM is usually a lobar process, but involvement of an entire lung is exceedingly rare. We present a small series of patients with multilobar CPAM who, to the best of our knowledge, are the first reported cases of giant CPAMs treated with pneumonectomy at birth. METHODS: After institutional review board approval, 93 medical records were reviewed for infants 0 to 12 months with congenital cystic adenomatoid malformation (CCAM) from 1990 to 2011...
October 2012: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/21853647/meconium-aspiration-syndrome-do-we-know
#15
REVIEW
Murat Yurdakök
Meconium is a common finding in amniotic fluid and placental specimens, particularly in the term or post-term pregnancy. The most important consequence of meconium-stained amniotic fluid (MSAF) is meconium aspiration syndrome (MAS), and at least 5% of infants born through MSAF develop MAS. MAS continues to be a threat to many newborns throughout the world, with a case fatality rate of 5% (as much as 40%), in addition to short- and long-term pulmonary and neurodevelopmental sequelae. The exact pathophysiology of meconium passage into the amniotic fluid and consequences of meconium aspiration are unknown...
March 2011: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/21649560/pulmonary-exposure-to-carbon-black-by-inhalation-or-instillation-in-pregnant-mice-effects-on-liver-dna-strand-breaks-in-dams-and-offspring
#16
Petra Jackson, Karin Sørig Hougaard, Anne Mette Z Boisen, Nicklas Raun Jacobsen, Keld Alstrup Jensen, Peter Møller, Gunnar Brunborg, Kristine Bjerve Gutzkow, Ole Andersen, Steffen Loft, Ulla Vogel, Håkan Wallin
Effects of maternal pulmonary exposure to carbon black (Printex 90) on gestation, lactation and DNA strand breaks were evaluated. Time-mated C57BL/6BomTac mice were exposed by inhalation to 42 mg/m(3) Printex 90 for 1 h/day on gestation days (GD) 8-18, or by four intratracheal instillations on GD 7, 10, 15 and 18, with total doses of 11, 54 and 268 μg/animal. Dams were monitored until weaning and some offspring until adolescence. Inflammation was assessed in maternal bronchoalveolar lavage (BAL) 3-5 days after exposure, and at weaning...
August 2012: Nanotoxicology
https://www.readbyqxmd.com/read/20362647/effects-of-prenatal-diesel-exhaust-inhalation-on-pulmonary-inflammation-and-development-of-specific-immune-responses
#17
Tuya Sharkhuu, Donald L Doerfler, Q Todd Krantz, Robert W Luebke, William P Linak, M Ian Gilmour
There is increasing evidence that exposure to air pollutants during pregnancy can result in a number of deleterious effects including low birth weight and the incidence of allergic asthma. To investigate the in utero effects of DE exposure, timed pregnant BALB/c mice were exposed to 0, 0.8 or 3.1 mg/m(3) of DE during gestation days (GD) 9 to GD 18. The number of successful pregnancies was 15/20 in the air controls and 10/20 in each of the diesel exposures. Immune function in the 6-week-old offspring as determined by development of delayed type hypersensitivity (DTH) reactions to bovine serum albumin (BSA), antibody titers to injected sheep red blood cells (SRBC), splenic T cells expressing CD45(+)CD3(+)CD8(+) and CD3(+)CD25(+), and mRNA expression of TNF-alpha, TLR2, SP-A, TGF-beta and Foxp3 in the lung were not affected by prenatal DE exposure...
June 16, 2010: Toxicology Letters
https://www.readbyqxmd.com/read/20211946/low-birth-weight-and-lung-function-in-adulthood-retrospective-cohort-study-in-china-1948-1996
#18
COMPARATIVE STUDY
Lijun Pei, Gong Chen, Jie Mi, Ting Zhang, Xinming Song, Jiapeng Chen, Ying Ji, Chengfu Li, Xiaoying Zheng
OBJECTIVE: The goal was to determine whether the components of low lung function in adulthood were associated with low birth weight in a Chinese population. METHODS: A retrospective cohort study was conducted from December 1995 to August 1996. A total of 627 men and women who were born between 1948 and 1954 were recruited; lung function indices were tested and respiratory diseases were examined in the Peking Union Medical College Hospital. Information on variables was recorded, and multivariate analysis of variance was performed to evaluate associations...
April 2010: Pediatrics
https://www.readbyqxmd.com/read/19292991/the-role-of-neuro-immune-cross-talk-in-the-regulation-of-inflammation-and-remodelling-in-asthma
#19
REVIEW
Tibor Z Veres, Sabine Rochlitzer, Armin Braun
Despite recent advances in the development of anti-asthmatic medication, asthma continues to be a major health problem worldwide. The symptoms of asthmatic patients include wheezing, chest tightness, cough and shortness of breath, which, together with airway hyperresponiveness, previously have been attributed to a dysfunction of airway nerves. However, research in the last two decades identified Th2-sensitization and the subsequent allergic reaction to innocuous environmental antigens as a basic immunological mechanism leading to chronic airway inflammation...
May 2009: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/19122105/ureaplasma-parvum-or-mycoplasma-hominis-as-sole-pathogens-cause-chorioamnionitis-preterm-delivery-and-fetal-pneumonia-in-rhesus-macaques
#20
Miles J Novy, Lynn Duffy, Michael K Axthelm, Drew W Sadowsky, Steven S Witkin, Michael G Gravett, Gail H Cassell, Kenneth B Waites
The authors assess causal, cellular and inflammatory links between intraamniotic infection with Ureaplasma parvum or Mycoplasma hominis and preterm labor in a nonhuman primate model. Long-term catheterized rhesus monkeys received intraamniotic inoculations of clinical isolates of Ureaplasma parvum serovar 1, M hominis, media control or physiological saline. Genital mycoplasmas were quantified in amniotic fluid (AF) and documented in fetal tissues by culture and PCR. In association with elevated AF colony counts for U parvum or M hominis, there was a sequential upregulation of AF leukocytes, proinflammatory cytokines, prostaglandin E2 and F2a, metalloproteinase-9 and uterine activity ( P< ...
January 2009: Reproductive Sciences
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