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https://www.readbyqxmd.com/read/29917324/effects-of-h1-antihistamine-addition-to-intranasal-corticosteroid-for-allergic-rhinitis-a-systematic-review-and-meta-analysis
#1
REVIEW
Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Dichapong Kanjanawasee, Likhit Khattiyawittayakun, Kornkiat Snidvongs
BACKGROUND: A combination of H1 antihistamine (AH) with intranasal corticosteroid (INCS) is commonly prescribed to patients with allergic rhinitis (AR) who have an inadequate response to monotherapy. In this systematic review we aimed to determine the effects of AH combined with INCS (AH-INCS) for treating AR. METHODS: Literature searches were performed using Medline and Embase. Randomized, controlled trials that studied the effects of AH-INCS vs INCS monotherapy for treating patients with AR were included...
June 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29917205/efficacy-and-safety-of-dipeptidyl-peptidase-4-inhibitors-in-the-treatment-of-type-2-diabetes-mellitus-patients-with-moderate-to-severe-renal-impairment-a-meta-analysis
#2
Y Chen, K Men, X-F Li, J Li, M Liu, Z-Q Fan
OBJECTIVE: Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of oral antidiabetic agents for type 2 diabetes mellitus (T2DM) patients. However, the effects and safety of DPP-4 inhibitors in T2DM patients with renal impairment (RI) remain controversial. Therefore, we conducted this meta-analysis to assess the efficacy and safety of DPP-4 inhibitors in T2DM patients with moderate to severe RI. MATERIALS AND METHODS: The PubMed, Embase, and Web of Science database were searched for published randomized controlled trials (RCTs), which compared DPP-4 inhibitors with placebo or a control regimen...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917092/systematic-review-and-meta-analysis-of-controlled-intervention-studies-on-the-effectiveness-of-long-chain-omega-3-fatty-acids-in-patients-with-nonalcoholic-fatty-liver-disease
#3
Kathy Musa-Veloso, Carolina Venditti, Han Youl Lee, Maryse Darch, Seth Floyd, Spencer West, Ryan Simon
Context: Treatment options for nonalcoholic fatty liver disease (NAFLD) are needed. Objective: The aim of this review was to systematically assess the effects of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs), particularly eicosapentaenoic acid and docosahexaenoic acid, on liver-related and metabolic outcomes in adult and pediatric patients with NAFLD. Data Sources: The online information service ProQuest Dialog was used to search 8 literature databases...
June 15, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29917045/the-association-between-gait-speed-and-cognitive-status-in-community-dwelling-older-people-a-systematic-review-and-meta-analysis
#4
Nancye May Peel, Linson John Alapatt, Lee Vanessa Jones, Ruth Eleanor Hubbard
Background: Gait speed and cognitive performance tend to decline with age. A better understanding of the dynamics of the association between gait speed and cognitive status may identify preclinical markers and improve diagnostic assessments. The objective was to quantify the association between gait speed and cognitive status in later life. Methods: A systematic search was undertaken of relevant databases for original articles published prior to June 2017, measuring the association between gait speed and cognition cross-sectionally or longitudinally among the community-dwelling population...
June 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29916349/antimicrobial-stewardship-in-veterinary-medicine
#5
David H Lloyd, Stephen W Page
While antimicrobial resistance is already a public health crisis in human medicine, therapeutic failure in veterinary medicine due to antimicrobial resistance remains relatively uncommon. However, there are many pathways by which antimicrobial resistance determinants can travel between animals and humans: by close contact, through the food chain, or indirectly via the environment. Antimicrobial stewardship describes measures that can help mitigate the public health crisis and preserve the effectiveness of available antimicrobial agents...
May 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29915945/pressure-matters-intrarenal-pressures-during-normal-and-pathological-conditions-and-impact-of-increased-values-to-renal-physiology
#6
REVIEW
Theodoros Tokas, Thomas R W Herrmann, Andreas Skolarikos, Udo Nagele
PURPOSE: To perform a review on the latest evidence related to normal and pathological intrarenal pressures (IRPs), complications of incremented values, and IRP ranges during endourology. METHODS: A literature search was performed using PubMed, restricted to original English-written articles, including animal, artificial model, and human studies. Different keywords were: percutaneous nephrolithotomy, PCNL, ureteroscopy, URS, RIRS, irrigation flow, irrigation pressure, intrarenal pressure, intrapelvic pressure and renal pelvic pressure...
June 18, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29915888/moyamoya-disease-in-pregnancy-a-systematic-review
#7
REVIEW
Georgios A Maragkos, Luis C Ascanio, Kohei Chida, Myles D Boone, Christopher S Ogilvy, Ajith J Thomas, Ekkehard M Kasper
BACKGROUND: Moyamoya disease (MMD) management during pregnancy poses a challenge to health care providers, and recommendations are outdated, vague, and controversial. We conducted a systematic review to investigate and present the available evidence. METHOD: We searched five online databases and bibliographies of relevant published original studies to identify case reports, case series, cohort studies, and reviews reporting on patients diagnosed with MMD before, during, or shortly after pregnancy...
June 19, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29915620/telemonitoring-and-hemodynamic-monitoring-to-reduce-hospitalization-rates-in-heart-failure-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-and-real-world-studies
#8
Gary Tse, Cynthia Chan, Mengqi Gong, Lei Meng, Jian Zhang, Xiao-Ling Su, Sadeq Ali-Hasan-Al-Saegh, Abhishek C Sawant, George Bazoukis, Yun-Long Xia, Ji-Chao Zhao, Alex Pui Wai Lee, Leonardo Roever, Martin Cs Wong, Adrian Baranchuk, Tong Liu
Background: Heart failure is a significant problem leading to repeated hospitalizations. Telemonitoring and hemodynamic monitoring have demonstrated success in reducing hospitalization rates, but not all studies reported significant effects. The aim of this systematic review and meta-analysis is to examine the effectiveness of telemonitoring and wireless hemodynamic monitoring devices in reducing hospitalizations in heart failure. Methods & Results: PubMed and Cochrane Library were searched up to 1st May 2017 for articles that investigated the effects of telemonitoring or hemodynamic monitoring on hospitalization rates in heart failure...
April 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29915538/efficacy-and-safety-of-once-weekly-semaglutide-for-the-treatment-of-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
Fang-Hong Shi, Hao Li, Min Cui, Zai-Li Zhang, Zhi-Chun Gu, Xiao-Yan Liu
Background: Semaglutide, a newly once-weekly glucagon like peptide-1 (GLP-1) receptor agonist, has showed a favorable effect on glycaemic control and weight reduction in type 2 diabetes mellitus (T2DM). This meta-analysis was conducted to evaluate the clinical efficacy and safety of semaglutide in T2DM. Methods: A comprehensive searching was performed for Phase III randomized controlled trials (RCTs) which reported the efficacy and safety data of semaglutide and other therapies. The efficacy data expressed as weight mean difference (WMD) and the safety data expressed as risk ratios (RRs) were calculated by employing random-effects model...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29914662/meta-analysis-indicates-that-resistant-starch-lowers-serum-total-cholesterol-and-low-density-cholesterol
#10
REVIEW
H C Yuan, Y Meng, H Bai, D Q Shen, B C Wan, L Y Chen
The effects of resistant starch (RS) on serum cholesterol levels have been previously investigated. However, the results of those studies are inconsistent. The purpose of our meta-analysis was to determine if RS affects blood lipids based on the current literature. The methods included searching databases (PubMed, Embase, Scopus, and Cochrane Library) up to September 2017, as well as hand-searching reference lists of articles published in English. The initial search yielded 1228 articles. Of these, 14 articles (20 trials) were included in our investigation focusing on the effects of RS on total cholesterol (TC; 19 trials), triglycerides (TG; 19 trials), low-density lipoprotein cholesterol (LDL-C; 16 trials), and high-density lipoprotein cholesterol (17 trials)...
June 2018: Nutrition Research
https://www.readbyqxmd.com/read/29914568/canine-breeds-associated-with-gastric-carcinoma-metaplasia-and-dysplasia-diagnosed-by-histopathology-of-endoscopic-biopsy-samples
#11
Marcus Vinicius Candido, Pernilla Syrjä, Susanne Kilpinen, Thomas Spillmann
BACKGROUND: Gastric carcinoma (GC) is a rather rare pathological finding in dogs, with the exception of some breeds which seem predisposed. The etiopathogenesis is largely unknown in dogs, whereas in humans GC often develops from gastric mucosal metaplasia and dysplasia. This study investigates whether dogs of certain breeds are more often subject to gastroduodenoscopy (GDS), and diagnosed with GC, mucosal metaplasia or dysplasia. A retrospective clinical database search was performed at the Veterinary Teaching Hospital at the University of Helsinki, Finland...
June 18, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29914534/efficacy-of-low-protein-diet-for-diabetic-nephropathy-a-systematic-review-of-randomized-controlled-trials
#12
Huan-Gao Zhu, Zhao-Shun Jiang, Pi-Yun Gong, Dong-Mei Zhang, Zhi-Wei Zou, Qian-Zhang, Hui-Mei Ma, Zhen-Gang Guo, Jun-Yu Zhao, Jian-Jun Dong, Lin-Liao
BACKGROUND: A low-protein diet (LPD) is believed to be beneficial in slowing the progression of kidney disease. It is reported that low protein diet can improve protein, sugar and lipid metabolism, and reduce the symptoms and complications of renal insufficiency. However, there has been controversial regarding the effects of protein restriction on diabetic nephropathy (DN). OBJECTIVE: To investigate the efficacy of LPD on renal function in patients with type 1 or 2 DN by meta-analysis of randomized controlled trials (RCTs)...
June 19, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29914296/meta-analysis-of-randomized-trials-on-percutaneous-patent-foramen-ovale-closure-for-prevention-of-migraine
#13
Ayman Elbadawi, Kirolos Barssoum, Ahmed S Abuzaid, Ahmed Rezq, Nishit Biniwale, Erfan Alotaki, Ahmed H Mohamed, Sowjanya Vuyyala, Gbolahan O Ogunbayo, Marwan Saad
BACKGROUND: The role of percutaneous patent foramen ovale (PFO) closure for prevention of migraine is controversial. METHODS: We performed a computerised search of MEDLINE, EMBASE and COCHRANE databases through December 2017 for randomised trials evaluating PFO closure versus control in patients with migraine headaches (with or without aura). The main study outcome was the reduction in monthly migraine attacks after PFO closure compared with the control group. RESULTS: The final analysis included three randomised trials with a total of 484 patients...
June 18, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29914254/evaluation-of-mesenteric-panniculitis-with-computed-tomography-benign-condition-or-paraneoplastic-syndrome
#14
Ali Küpeli, Ayşegül Cansu, Şükrü Oğuz, Süleyman Bekirçavuşoğlu, Süha Türkmen, Ali Ahmetoğlu, Gürkan Danışan
Background/aim: This study aimed to investigate the prevalence and association of mesenteric panniculitis (MP) with other diseases and the clinicoradiological features of MP, and to examine computed tomography findings to estimate the presence of malignancy in patients with MP. Materials and methods: Between September 2012 and August 2016, we used a keyword search to identify patients diagnosed with MP. Associated diseases and malignancies of patients were recorded. Cut-off values and diagnostic efficiencies of total MP scores and short and long diameters of the greatest lymph nodes were determined...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29913781/does-evidence-support-physiotherapy-management-of-adult-female-chronic-pelvic-pain-a-systematic-review
#15
S Loving, J Nordling, P Jaszczak, T Thomsen
Background and purpose Chronic pelvic pain (CPP) is a debilitating condition among women with a major impact on health-related quality of life, work productivity and health care utilisation. The exact prevalence of chronic pelvic pain is not known, but 3.8% is commonly suggested. Musculoskeletal dysfunction is frequently cited as a possible aetiology. Physiotherapy is therefore recommended as one treatment modality. The aim of this systematic review was to source and critically evaluate the evidence for an effect of physiotherapy on pain, physical activity and quality of life in the treatment of female CPP...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913645/a-pediatric-patients-pain-evaluation-in-the-emergency-unit
#16
Anette Lemström
AimsHelsinki University Hospital for Children and Adolescents treats 0-to 16-year old pediatric and surgical patients. The patients arrive to the emergency unit by ambulance, referral or by decision of the triage nurse. The most common reason for visit is pain. VAS pain scale should be used, but pain is not evaluated properly. The aim of this study was to review literature on evaluation and treatment of pain in pediatric emergency unit. MethodsA search from Cinahl and Finnish Medic-database covering last 10 years was performed using: pain, child, trauma, documentation, evaluation, emergency and assessment as keywords...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913526/tolerability-and-efficacy-of-ipragliflozin-in-the-management-of-inadequately-controlled-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#17
Ahmed Elgebaly, Nesrine Abdelazeim, Bassant Abdelazeim, Gehad El Ashal, Omar Mattar, Lubaba Namous, Noha Nasreldin
AIM: Ipragliflozin is a new antidiabetic agent that works through enhancing renal glucose excretion. We aim to synthesize evidence from published randomized controlled trials (RCTs) on the safety and efficacy of ipragliflozin in the management of type 2 diabetes mellitus (T2DM). METHODS: We searched PubMed, Scopus, Web of Science, and Cochrane Central register of clinical trials using relevant keywords. Records were screened for eligible studies and data were extracted and synthesized using Review Manager Version 5...
June 18, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29913275/rates-and-factors-associated-with-placebo-response-in-trials-of-pharmacotherapies-for-nonalcoholic-steatohepatitis-systematic-review-and-meta-analysis
#18
REVIEW
Ma Ai Thanda Han, Osama Altayar, Shadi Hamdeh, Varun Takyar, Yaron Rotman, Ohad Etzion, Eric Lefebvre, Rifaat Safadi, Vlad Ratziu, Larry J Prokop, Mohammad Hassan Murad, Mazen Noureddin
BACKGROUND & AIMS: Understanding the extent of the placebo effect in randomized controlled trials of studying nonalcoholic steatohepatitis (NASH) is important for optimal trial design, including sample size calculations and treatment endpoint definition. METHODS: We performed a systematic review and meta-analysis of the placebo groups from randomized controlled trials of adults with NASH that provided histological and/or magnetic resonance image-based measurements of intrahepatic triglyceride...
June 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29913256/the-effect-of-glucocorticoids-on-bone-mineral-density-in-patients-with-rheumatoid-arthritis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Anne-Birgitte Blavnsfeldt, Annette de Thurah, Malissa Dawn Thomsen, Simon Tarp, Bente Langdahl, Ellen-Margrethe Hauge
PURPOSE: The role of glucocorticoids in the treatment of rheumatoid arthritis (RA) is widely debated. Impairment of bone formation may be counter-balanced by reduced systemic inflammation. This review aims to assess the effect of prednisolone/prednisone on bone mineral density (BMD) in patients with RA analyzed in randomized, controlled trials. METHODS: We performed a systematic literature search and identified randomized, double-blinded placebo-controlled studies including patients with RA and using prednisolone or prednisone as the intervention...
June 15, 2018: Bone
https://www.readbyqxmd.com/read/29913231/a-systematic-review-and-meta-analysis-of-metal-concentrations-in-canned-tuna-fish-in-iran-and-human-health-risk-assessment
#20
Jamal Rahmani, Yadolah Fakhri, Ali Miri, Abbas Shahsavani, Zohreh Bahmani, Mauricio A Urbina, Salvatore Chirumbolo, Hassan Keramati, Bigard Moradi, Abotaleb Bay, Geir Bjørklund
Human consumption of fish protein, including canned tuna fish, is increasing steadily worldwide. However, there are some concerns about the potential exposure to elevated concentrations of metals in canned tuna fish. Several studies have been conducted in Iran regarding the concentration of metals in seafood, including copper (Cu), selenium (Se), iron (Fe), zinc (Zn), mercury (Hg), lead (Pb), chromium (Cr), arsenic (As), nickel (Ni), tin (Sn), and cadmium (Cd) in canned tuna fish. The main aim of this study was to gather data from existing papers and to perform a meta-analysis of the pooled concentrations of metals to evaluate their non-carcinogenic and carcinogenic risks in children and adults consumers...
June 15, 2018: Food and Chemical Toxicology
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