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https://www.readbyqxmd.com/read/28222368/direct-and-label-free-influenza-virus-detection-based-on-multisite-binding-to-sialic-acid-receptors
#1
Yukichi Horiguchi, Tatsuro Goda, Akira Matsumoto, Hiroaki Takeuchi, Shoji Yamaoka, Yuji Miyahara
A system to discriminate human or avian influenza A remains a highly sought-after tool for prevention of influenza pandemics in humans. Selective binding of the influenza A viral hemagglutinin (HA) to specific sialic acid (SA) receptors (Neu5Acα(2-6)Gal in humans, Neu5Acα(2-3)Gal in birds) is determined by the genotype of the HA and neuraminidase (NA) segments, making it one of the key characteristics that distinguishes human or avian influenza A virus. Here we demonstrate the direct detection of whole H1N1 influenza A virus using 6'-sialyllactose (Neu5Acα(2-6)Galβ(1-4)Glc, 6SL)-immobilized gold electrodes as biosensing surfaces...
February 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28222363/very-short-term-reactive-forecasting-of-the-solar-ultraviolet-index-using-an-extreme-learning-machine-integrated-with-the-solar-zenith-angle
#2
Ravinesh C Deo, Nathan Downs, Alfio V Parisi, Jan F Adamowski, John M Quilty
Exposure to erythemally-effective solar ultraviolet radiation (UVR) that contributes to malignant keratinocyte cancers and associated health-risk is best mitigated through innovative decision-support systems, with global solar UV index (UVI) forecast necessary to inform real-time sun-protection behaviour recommendations. It follows that the UVI forecasting models are useful tools for such decision-making. In this study, a model for computationally-efficient data-driven forecasting of diffuse and global very short-term reactive (VSTR) (10-min lead-time) UVI, enhanced by drawing on the solar zenith angle (θs) data, was developed using an extreme learning machine (ELM) algorithm...
February 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28222256/dynamic-melting-of-freezing-droplets-on-ultra-slippery-superhydrophobic-surfaces
#3
Fuqiang Chu, Xiaomin Wu, Lingli Wang
Condensed droplet freezing and freezing droplet melting phenomena on the prepared ultra-slippery superhydrophobic surface were observed and discussed in this study. Although the freezing delay performance of the surface is common, the melting of the freezing droplets on the surface is quite interesting. Three self-propelled movements of the melting droplets (ice water mixture) were found including the droplet rotating, the droplet jumping and the droplet sliding. The melting droplet rotating, which means that the melting droplet rotates spontaneously on the superhydrophobic surface like a spinning-top, is first reported in this study, and may have some potential applications in various engineering fields...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28222240/a-computerized-family-planning-counseling-aid-a%C3%A2-pilot%C3%A2-study-evaluation-of-smart-choices
#4
Helen P Koo, Ellen K Wilson, Alexandra M Minnis
CONTEXT: Resource constraints may make it challenging for family planning clinics to provide comprehensive contraceptive counseling; technological tools that help providers follow recommended practices without straining resources merit evaluation. METHODS: A pilot study using a two-group, posttest-only experimental design evaluated Smart Choices, a computer-based tool designed to help providers offer more patient-centered counseling and enable patients to participate proactively in the counseling session...
February 21, 2017: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/28221963/prevalence-and-antimicrobial-resistance-of-enterobacteriaceae-in-shell-eggs-from-small-scale-poultry-farms-and-farmers-markets
#5
A Kilonzo-Nthenge, S N Nahashon, S Godwin, S Liu, D Long
Public health concerns over the emergence of antimicrobial resistant bacteria have increased recently. The purpose of this study was to investigate the prevalence of antimicrobial resistant Enterobacteriaceae in shell eggs purchased from small poultry farms and farmers' markets. A total of 504 eggs were pooled to make 252 composite samples, consisting of 2 eggs per composite. The microbial quality of shell eggs was determined by standard quantitative, biochemical, and PCR techniques. Susceptibility to 13 antimicrobial agents was determined by the Kirby-Bauer disk diffusion technique, and results were interpreted based on Clinical and Laboratory Standards Institute values...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221819/a-prospective-study-of-endoscopic-injection-sclerotherapy-and-endoscopic-variceal-ligation-in-the-treatment-of-esophageal-varices
#6
Syed Mohsin Ali, Shanbin Wu, Hongwei Xu, Hui Liu, Jinghua Hao, Chengyong Qin
INTRODUCTION: The aim of this study was to compare the effectiveness and safety of endoscopic injection sclerotherapy (EIS) with endoscopic variceal ligation (EVL) in the management of esophageal variceal bleeding (EVB). PATIENTS AND METHODS: In this prospective study, we compared the EIS and EVL in 124 patients who had endoscopically proved bleeding from esophageal varices. According to different treatment methods, they were randomly divided into the EIS and the EVL groups...
October 24, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28220971/2d-materials-for-optical-modulation-challenges-and-opportunities
#7
REVIEW
Shaoliang Yu, Xiaoqin Wu, Yipei Wang, Xin Guo, Limin Tong
Owing to their atomic layer thickness, strong light-material interaction, high nonlinearity, broadband optical response, fast relaxation, controllable optoelectronic properties, and high compatibility with other photonic structures, 2D materials, including graphene, transition metal dichalcogenides and black phosphorus, have been attracting increasing attention for photonic applications. By tuning the carrier density via electrical or optical means that modifies their physical properties (e.g., Fermi level or nonlinear absorption), optical response of the 2D materials can be instantly changed, making them versatile nanostructures for optical modulation...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28220761/electrically-tunable-terahertz-polarization-converter-based-on-overcoupled-metal-isolator-metal-metamaterials-infiltrated-with-liquid-crystals
#8
Borislav Vasić, Dimitrios C Zografopoulos, Goran Isić, Romeo Beccherelli, Radoš Gajić
Large birefringence and its electrical modulation by means of Fréedericksz transition makes nematic liquid crystals (LCs) a promising platform for tunable terahertz (THz) devices. The thickness of standard LC cells is in the order of the wavelength, requiring high driving voltages and allowing only a very slow modulation at THz frequencies. Here, we first present the concept of overcoupled metal-isolator-metal (MIM) cavities that allow for achieving simultaneously both very high phase difference between orthogonal electric field components and large reflectance...
February 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28220275/open-source-vendor-independent-automated-multi-beat-tissue-doppler-echocardiography-analysis
#9
Niti M Dhutia, Massoud Zolgharni, Michael Mielewczik, Madalina Negoita, Stefania Sacchi, Karikaran Manoharan, Darrel P Francis, Graham D Cole
Current guidelines for measuring cardiac function by tissue Doppler recommend using multiple beats, but this has a time cost for human operators. We present an open-source, vendor-independent, drag-and-drop software capable of automating the measurement process. A database of ~8000 tissue Doppler beats (48 patients) from the septal and lateral annuli were analyzed by three expert echocardiographers. We developed an intensity- and gradient-based automated algorithm to measure tissue Doppler velocities. We tested its performance against manual measurements from the expert human operators...
February 20, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28220187/-emergency-medical-training-through-simulation-always-the-same-for-everyone
#10
A Schaumberg, T Schröder, M Sander
Simulation assumes a growing importance in the field of emergency medical education. Many rescue service schools work with simulators or even have their own simulation center. Classic resuscitation training in the classroom is increasingly being replaced by realistic case scenarios. But simulators themselves do not train! Using a simulator in emergency medical training does not necessarily mean achieving sustained learning success among the participants. Depending on the skills, abilities or competences being taught, there seems to be different requirements for simulation...
February 20, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28220100/season-and-weather-effects-on-travel-related-mood-and-travel-satisfaction
#11
Dick Ettema, Margareta Friman, Lars E Olsson, Tommy Gärling
This study examines the effects of season and weather on mood (valence and activation) and travel satisfaction (measured by the Satisfaction with Travel Scale). Analyses are presented of 562 time-sampled morning commutes to work made by 363 randomly sampled people in three different Swedish cities asking them to use smartphones to report their mood in their home before and directly after the commutes. These reports as well as satisfaction with the commute obtained in summer and winter are linked to weather data and analyzed by means of fixed-effects regression analyses...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28219799/uplc-ms-ms-method-for-the-simultaneous-quantification-of-three-new-antiretroviral-drugs-dolutegravir-elvitegravir-and-rilpivirine-and-other-thirteen-antiretroviral-agents-plus-cobicistat-and-ritonavir-boosters-in-human-plasma
#12
Marco Simiele, Alessandra Ariaudo, Amedeo De Nicolò, Fabio Favata, Martina Ferrante, Chiara Carcieri, Stefano Bonora, Giovanni Di Perri, Antonio De Avolio
Rilpivirine (RPV), dolutegravir (DTG) and elvitegravir (EVG) are the latest antiretroviral drugs approved for treatment of HIV infection. Currently, poor information is currently available concerning their pharmacokinetic and pharmacodynamic properties, thus making the use of therapeutic drug monitoring for these drugs not useful. This lack of information is partially due to the absence of an high-throughput method for their simultaneous quantification together with other antiretroviral drugs. In this work, we describe the development and validation of a new UPLC-MS/MS method to quantify these drugs, together with other fourteen antiretroviral agents, in human plasma...
February 3, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28219777/nutrition-metabolism-and-targeting-aging-in-nonhuman-primates
#13
REVIEW
Priya Balasubramanian, Julie A Mattison, Rozalyn M Anderson
This short review focuses on the importance of nonhuman primate nutrition and aging studies and makes the case that a targeted expansion of the use of this highly translatable model would be advantageous to the biology of aging field. First, we describe the high degree of similarity of the model in terms of aging phenotypes including incidence and prevalence of common human age-related diseases. Second, we discuss the importance of the nonhuman primate nutrition and aging studies and the extent to which the outcomes of two ongoing long-term studies of caloric restriction are congruent with short-term equivalent studies in humans...
February 17, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28219638/traffic-safety-effects-of-new-speed-limits-in-sweden
#14
Anna Vadeby, Åsa Forsman
The effects of speed, both positive and negative, make speed a primary target for policy action. Driving speeds affect the risk of being involved in a crash and the injury severity as well as the noise and exhaust emissions. Starting 2008, the Swedish Transport Administration performed a review of the speed limits on the national rural road network. This review resulted in major changes of the speed limits on the rural road network. It was predominantly roads with a low traffic safety standard and unsatisfactory road sides that were selected for reduced speed limits, as well as roads with a good traffic safety record being selected for an increase in speed limits...
February 17, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28219478/assessment-of-the-multi-criteria-evaluation-system-of-the-welfare-quality%C3%A2-protocol-for-growing-pigs
#15
I Czycholl, C Kniese, L Schrader, J Krieter
Animal welfare has become an important subject of public and political debate, leading to the necessity of an objective evaluation system for on-farm use. As welfare is a multi-dimensional concept, it makes sense to use a multi-criteria aggregation system to obtain an overall welfare score. Such an aggregation system is provided by the Welfare Quality® Network. The present paper focusses on the assessment of the multi-criteria evaluation model included in the Welfare Quality® protocol for growing pigs in order to aggregate the animal-based indicators first to criteria, then to principles and finally to an overall welfare score...
February 21, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28219392/meaning-and-barriers-to-quality-care-service-provision-in-child-and-adolescent-mental-health-services-qualitative-study-of-stakeholder-perspectives
#16
Nadzeya Svirydzenka, Pablo Ronzoni, Nisha Dogra
BACKGROUND: Defining quality in health presents many challenges. The Institute of Medicine (IOM) defined quality clinical care as care that is equitable, timely, safe, efficient, effective and patient centred. However, it is not clear how different stakeholders within a child and adolescent mental health service (CAMHS) understand and/or apply this framework. This project aims to identify key stakeholders" understanding of the meaning of quality in the context of CAMHS. METHOD: The study sample comprised of three groups: (i) patients and carers, (ii) CAMHS clinical staff, and (iii) commissioners (Total N = 24)...
February 20, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28219348/distribution-based-nearest-neighbor-imputation-for-truncated-high-dimensional-data-with-applications-to-pre-clinical-and-clinical-metabolomics-studies
#17
Jasmit S Shah, Shesh N Rai, Andrew P DeFilippis, Bradford G Hill, Aruni Bhatnagar, Guy N Brock
BACKGROUND: High throughput metabolomics makes it possible to measure the relative abundances of numerous metabolites in biological samples, which is useful to many areas of biomedical research. However, missing values (MVs) in metabolomics datasets are common and can arise due to both technical and biological reasons. Typically, such MVs are substituted by a minimum value, which may lead to different results in downstream analyses. RESULTS: Here we present a modified version of the K-nearest neighbor (KNN) approach which accounts for truncation at the minimum value, i...
February 20, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28219015/the-expectations-of-antenatal-screening-and-experiences-of-the-first-trimester-screening-scan
#18
Maarit Nykänen, Katri Vehviläinen-Julkunen, Reija Klemetti
AIM: to describe the expectations to and knowledge of antenatal screening of expecting parents, and their experiences concerning the first-trimester screening scan. DESIGN: survey study with a consecutive sampling method. SETTING: two hospital districts in Finland, namely the capital area and Eastern Finland. Together these two districts include the six different municipal units in which the first-trimester screening scans discussed in the study were done during spring 2015...
February 15, 2017: Midwifery
https://www.readbyqxmd.com/read/28218502/serous-tubal-intraepithelial-carcinomas-associated-with-high-grade-serous-ovarian-carcinomas-a-systematic-review
#19
REVIEW
F Chen, K Gaitskell, M J Garcia, A Albukhari, J Tsaltas, A A Ahmed
BACKGROUND: Serous tubal intraepithelial carcinomas (STICs) have been documented in high-grade serous ovarian carcinomas (HGSOCs). However, the rate of association between STICs and HGSOCs and, therefore, the fraction of HGSOCs that are likely to have originated from the fallopian tube (FT), has remained unclear. OBJECTIVE: To appraise the literature describing the association between STICs and established HGSOCs. SEARCH STRATEGY: Ovid MEDLINE and EMBASE were searched...
February 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28217731/relationship-between-the-physical-and-psychosocial-conditions-of-postoperative-gastrointestinal-cancer-patients-and-their-responses-to-an-informational-material
#20
Michiyo Mizuno, Jun Kataoka, Fumiko Oishi
OBJECTIVE: Postoperative patients with gastrointestinal (GI) cancer have multiple adaptation tasks and care needs to improve their quality of life (QOL). Whether their supportive care needs differ according to their physical and psychosocial conditions is unclear. This study investigated patients' (1) physical and psychosocial conditions (QOL, fatigue, anxiety, cognitive plight, and resilience) and (2) responses to an informational booklet describing cancer patients' problems and adaptation tasks, and examined the association between the two factors...
January 2017: Asia-Pacific Journal of Oncology Nursing
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