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Christian Hetzel, Marco Streibelt
BACKGROUND AND OBJECTIVE: Vocational retrainings (VR) in the context of vocational rehabilitation are lengthy and expansive interventions. The question is whether the return to work (RTW) 12 months after VR can be a proxy variable for long term income trajectories. METHODS: Based on register data of the German Pension Insurance (Scientific Use File SUFRSDLV09B) fixed-effects-regressions were calculated to measure the effect of VR on the annual mean daily income in each of the 3 years after VR compared to initial level prior to VR and depending on the RTW...
June 2018: Die Rehabilitation
Julio Cesar Teixeira, Carlos Afonso Maestri, Helymar da Costa Machado, Luiz Carlos Zeferino, Newton Sérgio de Carvalho
OBJECTIVE:  The aim of this study was to assess the time trends and pattern of cervical cancer diagnosed in the period from 2001 to 2012 by means of an opportunistic screening program from two developed regions in Brazil. METHODS:  An observational study analyzing 3,364 cancer records ( n  = 1,646 from Campinas and n  = 1,718 from Curitiba region) available in hospital-based cancer registries was done. An additional 1,836 records of CIN3/AIS from the region of Campinas was analyzed...
June 20, 2018: Revista Brasileira de Ginecologia e Obstetrícia
Oommen Mathew Arikupurathu, Linda Johnston, Alasdair MacInnes, Graeme Nicol, Manhal Nassif
The NexGen legacy posterior stabilized (LPS) prosthesis was introduced in 1997 after many design changes to its predecessor, the Insall-Burstein II prosthesis. However, there have been no reported long-term studies on the performance of this implant. Prospectively, collected data from a local database comprising primary total knee replacements (TKRs) with LPS between 1997 and 2002 was analyzed. All implants were fixed with cement. Patients were followed up at 1, 3, 5, 7, and 10 years, with patient satisfaction, range of movement, and Knee Society score (KSS) assessed...
June 20, 2018: Journal of Knee Surgery
Anne Tiedemann, Sandra O'Rourke, Catherine Sherrington
Objectives and importance of study: Yoga improves balance and mobility, and therefore has potential as a fall prevention strategy, yet its validity for preventing falls has not been established. The Otago Exercise Programme (OEP) and tai chi are proven to prevent falls. This study aimed to evaluate the perceptions and preferences of older people towards a yoga-based program with potential to decrease falls, to compare these perceptions to the views expressed about the OEP and tai chi, and to identify participant characteristics associated with a preference for the yoga program...
June 14, 2018: Public Health Research & Practice
Jin Soon Hwang, Hae Sang Lee, Kee-Hyoung Lee, Han-Wook Yoo, Dae-Yeol Lee, Byung-Kyu Suh, Cheol Woo Ko, Woo Yeong Chung, Dong-Kyu Jin, Choong Ho Shin, Heon-Seok Han, Song Han, Ho-Seong Kim
BACKGROUND/AIMS: To determine the optimal dose of LB03002, a sustained-release, once-weekly formulation of recombinant human growth hormone (rhGH), and to compare its efficacy and safety with daily rhGH in children with idiopathic short stature (ISS). METHODS: This multicenter, randomized, open-label, phase II study included GH-naïve, prepubertal children with ISS, randomized to receive daily rhGH 0.37 mg/kg/week (control, n = 16), LB03002 0.5 mg/kg/week (n = 14), or LB03002 0...
June 20, 2018: Hormone Research in Pædiatrics
Dianne E C van Beek, Iwan C C van der Horst, A Fred de Geus, Massimo A Mariani, Thomas W L Scheeren
PURPOSE: Low serum albumin (SA) is a prognostic factor for poor outcome after cardiac surgery. The aim of this study was to estimate the association between pre-operative SA, early post-operative SA and postoperative myocardial injury. METHODS: This single center cohort study included adult patients undergoing cardiac surgery during 4 consecutive years. Postoperative myocardial damage was defined by calculating the area under the curve (AUC) of troponin (Tn) values during the first 72 h after surgery and its association with SA analyzed using linear regression and with multivariable linear regression to account for patient related and procedural confounders...
June 6, 2018: Journal of Critical Care
A Kerasnoudis, P Ntasiou, G Barmpalios
INTRODUCTION: We report on the prognostic role of cross sectional area (CSA) enlargement and axonal damage in traumatic sural neuropathy (TSN). METHODS: Reference values were defined in 23 healthy subjects. 13patients with TSN underwent evaluation (Thessaloniki Hypesthesia Score (THS), ultrasound, electrophysiology). All patients were followed up with THS 6 months after initial evaluation. RESULTS: During initial evaluation, the 13 patients showed a mean THS of 2...
June 13, 2018: Journal of Electromyography and Kinesiology
Wenlong Xu, Elaheh Alizadeh, Ashok Prasad
A single-cell assay of active and passive intracellular mechanical properties of mammalian cells could give significant insight into cellular processes. Force spectrum microscopy (FSM) is one such technique, which combines the spontaneous motion of probe particles and the mechanical properties of the cytoskeleton measured by active microrheology using optical tweezers to determine the force spectrum of the cytoskeleton. A simpler and noninvasive method to perform FSM would be very useful, enabling its widespread adoption...
June 19, 2018: Biophysical Journal
Fouzia Bano, Markku I Tammi, David W Kang, Edward N Harris, Ralf P Richter
The extracellular polysaccharide hyaluronan (HA) is ubiquitous in all vertebrate tissues, where its various functions are encoded in the supramolecular complexes and matrices that it forms with HA-binding proteins (hyaladherins). In tissues, these supramolecular architectures are frequently subjected to mechanical stress, yet how this affects the intermolecular bonding is largely unknown. Here, we used a recently developed single-molecule force spectroscopy platform to analyze and compare the mechanical strength of bonds between HA and a panel of hyaladherins from the Link module superfamily, namely the complex of the proteoglycan aggrecan and cartilage link protein, the proteoglycan versican, the inflammation-associated protein TSG-6, the HA receptor for endocytosis (stabilin-2/HARE), and the HA receptor CD44...
June 19, 2018: Biophysical Journal
H R Sowman, N J Cave, M Dunowska
AIMS: To determine which of the common canine respiratory pathogens circulate among selected populations of healthy and diseased dogs in New Zealand. METHODS: Coagulated blood samples for serology and oropharyngeal swabs for virology were collected from healthy dogs (n=47) and from dogs with acute respiratory disease (n=49). For diseased dogs a convalescent blood sample was also collected 3-4 weeks later. Oropharyngeal swabs were subjected to virus isolation and tested for canine parainfluenza virus (CPIV), canine adenovirus (CAdV) 2, canine herpesvirus (CHV), canine respiratory coronavirus (CRCoV), canine influenza virus (CIV), canine distemper virus (CDV), Bordetella bronchiseptica, Streptococcus equi subsp...
June 20, 2018: New Zealand Veterinary Journal
Edward J Goetzl, Carlos Nogueras-Ortiz, Maja Mustapic, Roger J Mullins, Erin L Abner, Janice B Schwartz, Dimitrios Kapogiannis
Exosomes derived from chondroitin sulfate proteoglycan (CSPG) 4 type neural precursor cells (CSPG4Es) were purified from human plasma by sequential immunoabsorption with anti-CSPG4 and anti-platelet growth factor receptor α mAb to characterize the potential in vivo roles of CSPG4 cells in neuronal repair. Hepatocyte growth factor, fibroblast growth factors (FGFs)-2 and -13, and type 1 insulin-like growth factor (IGF-1), which enhance neuronal survival and functions, were quantified in CSPG4E extracts. For CSPG4Es of 24 healthy control subjects, mean levels of hepatocyte growth factor, FGF-13, and IGF-1, but not FGF-2, were significantly higher by up to 7-fold than in their neuronal-derived exosomes, and mean levels of all 4 growth factors were significantly higher by up to 8-fold than in their astrocyte-derived exosomes...
June 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Eric A Miller, Yara Jabbour Al Maalouf, Hadley D Sikes
In this work, we characterize the impact of large-volume processing upon the analytical sensitivity of flow-through paper-based immunoassays. Larger sample volumes feature greater molar quantities of available analyte, but the assay design principles which would enable the rapid collection of this dilute target are ill-defined. We developed a finite-element model to explore the operat-ing conditions under which processing large sample volumes via pressure-driven convective flow would yield improved binding signal...
June 20, 2018: Analytical Chemistry
Mary C Tolcher, Sherif A Shazly, Alireza A Shamshirsaz, William E Whitehead, Jimmy Espinoza, Alex C Vidaeff, Michael A Belfort, Ahmed A Nassr
BACKGROUND: Controversy exists regarding the optimal mode of delivery for fetuses with open neural tube defects. OBJECTIVE: To compare neurological outcomes among infants with open neural tube defects who underwent vaginal compared to caesarean delivery. SEARCH STRATEGY: Electronic databases MEDLINE, EMBASE, Scopus, and Clinicaltrials. gov were searched from inception to November 2017. SELECTION CRITERIA: Eligible studies included observational or randomised studies comparing vaginal and caesarean delivery in pregnancies with fetal open neural tube defects who did not undergo prenatal repair...
June 20, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Ting Fan, Ao Wang, Jia-Qi Li, Jian-Liang Ye, Xiao Zheng, Pei-Qiang Huang
The imino-Nazarov cyclization of the polysubstituted pentan-1,4-diene-3-imine is realized. To this aim, a one-pot procedure involving reductive alkenyliminylation of α,β-unsaturated secondary amides with potassium organotrifluoroborates followed by acid-catalyzed imino-Nazarov cyclization of the polysubstituted pentan-1,4-diene-3-imine intermediates is studied systematically. This mild, operationally simple, flexible, and high-yielding protocol efficiently affords polysubstituted pentan-1,4-diene-3-imines, cyclopentenimines, and α-amino cyclopentenones, which are useful scaffolds in organic synthesis...
June 20, 2018: Angewandte Chemie
Laura Pedrosa-Rodriguez, D A Outerelo, Francisco J Diaz-Otero
In this work we design, by means of a non-neutral plasma method, a linear trapping model for large ion clouds, which will become the core of an atomic clock. We first obtain the geometry and electromagnetic characteristics of the ion trap. We then perform a systematic analysis describing the main parameters of the ion cloud such as size, secular frequency and ion number per unit length in terms of temperature. The most appropriate operation point of the ion trap in terms of a set of these specific parameters is evaluated and a thorough discussion is performed about how minor perturbations introduced in these parameters affect, in a nonlinear response, the performance of the trapping system in terms of sensibility, heating and RF potential...
June 20, 2018: Journal of Mass Spectrometry: JMS
Robert A Jane, David J Simmonds, Ben P Gouldby, Jonathan D Simm, Luciana Dalla Valle, Alison C Raby
In flood risk analysis, limitations in the multivariate statistical models adopted to model the hydraulic load have restricted the probability of a defense suffering structural failure to be expressed conditionally on a single hydraulic loading variable. This is an issue at the coastal level where multiple loadings act on defenses with the exact combination of loadings dictating their failure probabilities. Recently, a methodology containing a multivariate statistical model with the flexibility to robustly capture the dependence structure between the individual loadings was used to derive extreme nearshore loading conditions...
June 20, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
Claire E Kendall, Esther Susanna Shoemaker, Lisa Boucher, Danielle E Rolfe, Lois Crowe, Marissa Becker, Shabnam Asghari, Sean B Rourke, Ron Rosenes, Christine Bibeau, Philip Lundrigan, Clare Liddy
HIV treatment in Canada has rapidly progressed with the advent of new drug therapies and approaches to care. With this evolution, there is increasing interest in Canada in understanding the current delivery of HIV care, specifically where care is delivered, how, and by whom, to inform the design of care models required to meet the evolving needs of the population. We conducted a cross-sectional survey of Canadian care settings identified as delivering HIV care between June 2015 and January 2016. Given known potential differences in delivery approaches, we stratified settings as primary care or specialist settings, and described their structure, geographic location, populations served, health human resources, technological resources, and available clinical services...
2018: PloS One
Akira Shiono, Jiro Kogo, Hiroki Sasaki, Ryo Yomoda, Tatsuya Jujo, Naoto Tokuda, Yasushi Kitaoka, Hitoshi Takagi
PURPOSE: To examine the relationship between optical coherence tomography (OCT) images and clinical course in eyes with branch retinal vein occlusion (BRVO) treated with intravitreal ranibizumab injection (IVR). DESIGN: Prospective cohort study. PARTICIPANTS: Thirty eyes of 30 patients with BRVO treated with IVR. METHODS: All patients received 1 initial IVR followed by repeated injections in the pro re nata (PRN) regimen...
2018: PloS One
Marika Pane, Giorgia Coratti, Claudia Brogna, Elena Stacy Mazzone, Anna Mayhew, Lavinia Fanelli, Sonia Messina, Adele D'Amico, Michela Catteruccia, Marianna Scutifero, Silvia Frosini, Valentina Lanzillotta, Giulia Colia, Filippo Cavallaro, Enrica Rolle, Roberto De Sanctis, Nicola Forcina, Roberta Petillo, Andrea Barp, Alice Gardani, Antonella Pini, Giulia Monaco, Maria Grazia D'Angelo, Riccardo Zanin, Gian Luca Vita, Claudio Bruno, Tiziana Mongini, Federica Ricci, Elena Pegoraro, Luca Bello, Angela Berardinelli, Roberta Battini, Valeria Sansone, Emilio Albamonte, Giovanni Baranello, Enrico Bertini, Luisa Politano, Maria Pia Sormani, Eugenio Mercuri
The aim of the study was to establish 24 month changes in upper limb function using a revised version of the performance of upper limb test (PUL 2.0) in a large cohort of ambulant and non-ambulant boys with Duchenne muscular dystrophy and to identify possible trajectories of progression. Of the 187 patients studied, 87 were ambulant (age range: 7-15.8 years), and 90 non-ambulant (age range: 9.08-24.78). The total scores changed significantly over time (p<0.001). Non-ambulant patients had lower total scores at baseline (mean 19...
2018: PloS One
Sambit Kumar Mishra, Robert L Jernigan
Dynamic communities in proteins comprise the cohesive structural units that individually exhibit rigid body motions. These can correspond to structural domains, but are usually smaller parts that move with respect to one another in a protein's internal motions, key to its functional dynamics. Previous studies emphasized their importance to understand the nature of ligand-induced allosteric regulation. These studies reported that mutations to key community residues can hinder transmission of allosteric signals among the communities...
2018: PloS One
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