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https://www.readbyqxmd.com/read/29168159/lox-1-is-a-poor-prognostic-indicator-and-induces-epithelial-mesenchymal-transition-and-metastasis-in-pancreatic-cancer-patients
#1
Jie Zhang, Lei Zhang, Can Li, Caiting Yang, Lili Li, Shushu Song, Hao Wu, Fenglin Liu, Lan Wang, Jianxin Gu
PURPOSE: Pancreatic cancer (PC) is an aggressive type of cancer that exhibits a rapid progression. Previously LOX-1, which is a type II trans-membrane glycoprotein that is expressed in endothelial cells, has been found to be involved in the development of several types of cancer. As yet, however, the expression of LOX-1 and its functional consequences in PC have not been documented. The present study was aimed at investigating the prognostic relevance of LOX-1 expression in PC patients and at resolving its role in PC metastasis...
November 22, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29167290/evaluation-of-whole-genome-sequencing-for-mycobacterial-species-identification-and-drug-susceptibility-testing-in-a-clinical-setting-a-large-scale-prospective-assessment-of-performance-against-line-probe-assays-and-phenotyping
#2
T Phuong Quan, Zharain Bawa, Dona Foster, Tim Walker, Carlos Del Ojo Elias, Priti Rathod, Zamin Iqbal, Phelim Bradley, Janet Mowbray, A Sarah Walker, Derrick W Crook, David H Wyllie, Timothy E A Peto, E Grace Smith
Use of whole genome sequencing (WGS) for routine Mycobacterial species identification and drug susceptibility testing (DST) is becoming a reality. We compared performance of WGS and standard laboratory workflows prospectively, by parallel processing at a major Mycobacterial Reference Service over one year, for species identification, first-line Mycobacterium tuberculosis (TB) resistance prediction, and turnaround time. Of 2039 isolates with line-probe results for species identification, 74 (3.6%) failed sequencing or WGS species identification...
November 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29166565/hospital-based-physicians-intubation-decisions-and-associated-mental-models-when-managing-a-critically-and-terminally-ill-older-patient
#3
Shannon Haliko, Julie Downs, Deepika Mohan, Robert Arnold, Amber E Barnato
BACKGROUND: Variation in the intensity of acute care treatment at the end of life is influenced more strongly by hospital and provider characteristics than patient preferences. OBJECTIVE: We sought to describe physicians' mental models (i.e., thought processes) when encountering a simulated critically and terminally ill older patient, and to compare those models based on whether their treatment plan was patient preference-concordant or preference-discordant. METHODS: Seventy-three hospital-based physicians from 3 academic medical centers engaged in a simulated patient encounter and completed a mental model interview while watching the video recording of their encounter...
November 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29165509/-evaluation-of-xpert%C3%A2-mtb-rif-technique-for-mycobacterium-tuberculosis-complex-detection-in-extra-respiratory-specimens
#4
Patricia García, M Elvira Balcells, Claudia Castillo, Carolina Miranda, Enrique Geoffroy, Juan C Román, Aniela Wozniak
Extra-pulmonary tuberculosis (TB) represents the 26.2% of total TB cases in Chile. Culture is the gold standard method, but the process is extremely slow. Xpert®MTB/RIF technique detects Mycobacterium tuberculosis complex (MTBc) through real time PCR in less than 3 h. However, it has been validated only for respiratory specimens. We aimed to determine the performance of Xpert®MTB/RIF test in detecting MTBc in extra-respiratory specimens compared with a combined gold standard consisting in a positive (liquid and solid) mycobacterial culture and/or a positive validated molecular method (q-RPC, Cobas®TaqMan®-MTB)...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29164969/accuracy-of-self-reported-family-history-of-cancer-mutation-status-and-tumor-characteristics-in-patients-with-early-onset-breast-cancer
#5
Annelie Augustinsson, Carolina Ellberg, Ulf Kristoffersson, Åke Borg, Håkan Olsson
BACKGROUND: The main objectives of this study were to evaluate the concordance between self-reported and registry-reported information regarding family history of breast cancer (BC), ovarian cancer (OvC) and other types of cancer in first-degree relatives of patients with early onset BC, and to determine the frequency of mutation carriers and non-mutation carriers. The secondary objective was to describe tumor characteristics for each mutation group. MATERIAL AND METHODS: Between 1993 and 2013, 231 women who were ≤35 years old when diagnosed with BC were registered at the Oncogenetic Clinic at Skåne University Hospital in Lund, Sweden...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29163793/rapid-ultra-low-coverage-copy-number-profiling-of-cell-free-dna-as-a-precision-oncology-screening-strategy
#6
Daniel H Hovelson, Chia-Jen Liu, Yugang Wang, Qing Kang, James Henderson, Amy Gursky, Scott Brockman, Nithya Ramnath, John C Krauss, Moshe Talpaz, Malathi Kandarpa, Rashmi Chugh, Missy Tuck, Kirk Herman, Catherine S Grasso, Michael J Quist, Felix Y Feng, Christine Haakenson, John Langmore, Emmanuel Kamberov, Tim Tesmer, Hatim Husain, Robert J Lonigro, Dan Robinson, David C Smith, Ajjai S Alva, Maha H Hussain, Arul M Chinnaiyan, Muneesh Tewari, Ryan E Mills, Todd M Morgan, Scott A Tomlins
Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications. In advanced cancer, disease burden and cfDNA tumor content are often elevated, yielding unique precision oncology opportunities. We sought to demonstrate the utility of a pan-cancer, rapid, inexpensive, whole genome NGS of cfDNA approach (PRINCe) as a precision oncology screening strategy via ultra-low coverage (~0.01x) tumor content determination through genome-wide copy number alteration (CNA) profiling...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163429/relationship-between-gingival-crevicular-fluid-microbiota-and-cytokine-profile-in-periodontal-host-homeostasis
#7
Jianye Zhou, Yiqing Yao, Kangli Jiao, Jumei Zhang, Xin Zheng, Fang Wu, Xiaopan Hu, Junping Li, Zhanhai Yu, Gaosen Zhang, Nan Jiang, Zhiqiang Li
As potential biomarkers in periodontitis, microbiome, and cytokines have recently been extensively investigated, but combined analyses of the variations between the microbial structure and cytokine composition are rare. The present study aimed to investigate whether there are differences in the combined profile of microbiome and cytokines in individuals with or without periodontitis. The microbiome and cytokine composition in gingival crevicular fluid (GCF) from 16 patients and 15 controls from Jishi Shan (Gansu, China) were analyzed using 454 pyrosequencing and RayBio Quantibody Arrays...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29161262/the-value-of-confirmatory-testing-in-early-infant-hiv-diagnosis-programmes-in-south-africa-a-cost-effectiveness-analysis
#8
Lorna Dunning, Jordan A Francke, Divya Mallampati, Rachel L MacLean, Martina Penazzato, Taige Hou, Landon Myer, Elaine J Abrams, Rochelle P Walensky, Valériane Leroy, Kenneth A Freedberg, Andrea Ciaranello
BACKGROUND: The specificity of nucleic acid amplification tests (NAATs) used for early infant diagnosis (EID) of HIV infection is <100%, leading some HIV-uninfected infants to be incorrectly identified as HIV-infected. The World Health Organization recommends that infants undergo a second NAAT to confirm any positive test result, but implementation is limited. Our objective was to determine the impact and cost-effectiveness of confirmatory HIV testing for EID programmes in South Africa...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29159975/rcat-reflects-symptom-control-and-quality-of-life-in-allergic-rhinoconjunctivitis-patients
#9
J-P Liedtke, A Mandl, J Köther, J Chwieralski, K Shah-Hosseini, U Pieper-Fürst, S Allekotte, R Mösges
BACKGROUND: The Global Allergy and Asthma European Network (GA(2) LEN) Taskforce has requested more data on correlations between various Patient Reported Outcomes (PROs) in clinical trials on allergy. We compared three tools-the Rhinitis Control Assessment Test (RCAT), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and Rhinitis Total Symptom Score (RTSS)-to determine whether the RCAT alone is a sufficient primary outcome parameter in clinical trials on allergic rhinoconjunctivitis...
November 21, 2017: Allergy
https://www.readbyqxmd.com/read/29159925/the-use-of-micro-ct-imaging-to-examine-and-illustrate-fetal-skeletal-abnormalities-in-dutch-belted-rabbits-and-to-prove-concordance-with-alizarin-red-stained-skeletal-examination
#10
Howard M Solomon, Stacia Murzyn, Joyce Rendemonti, Sharon Chapman, Tinamarie Skedzielewski, Beat M Jucker, Dinesh Stanislaus, Hasan Alsaid
OBJECTIVES: In our laboratory we evaluated the use of micro-computed tomography (micro-CT) using a high resolution acquisition protocol and fetuses obtained on Gestation Day (GD) 29 (mating = GD 0). METHODS: To show concordance between traditional Alizarin Red S stain and micro-CT skeletal examination methods, 103 fetuses from 19 untreated Dutch belted rabbits were obtained by cesarean section and stored frozen. The fetuses were thawed, imaged and examined digitally by micro-CT, then stained and re-examined using traditional methods...
November 21, 2017: Birth defects research
https://www.readbyqxmd.com/read/29159696/reflex-testing-of-speckled-cytoplasmic-patterns-observed-in-routine-ana-hep-2-indirect-immunofluorescence-with-a-multiplex-anti-synthetase-dot-blot-assay-a-multicentric-pilot-study
#11
Maria Infantino, Boaz Palterer, Roberta Biagiotti, Fabio Almerigogna, Maurizio Benucci, Arianna Damiani, Valentina Grossi, Annalisa Azzurri, Patrizia Casprini, Giovanni Bacci, Maria Grazia Giudizi, Mariangela Manfredi
Immunofluorescence on HEp2-cells is the standard diagnostic assay for the detection of anti-nuclear antibodies (ANA). Cytoplasmic speckled patterns are a common finding, and are associated with various antibodies, including anti-synthetase antibodies. However, classic ENA testing generally identifies only anti-Jo-1. Moreover, anti-synthetase syndrome is increasingly recognized as a pleomorphic entity, possibly presenting as isolated arthritis or interstitial lung disease. Sera referred for routine ANA testing were selected on the basis of the presence of a fine dense speckled cytoplasmic pattern (254 samples) and compared to control sera with negative cytoplasm (239 samples)...
November 21, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29157922/development-and-electronic-validation-of-the-revised-cystic-fibrosis-questionnaire-cfq-r-teen-adult-new-tool-for-monitoring-psychosocial-health-in-cf
#12
Amparo Solé, Casilda Olveira, Ines Pérez, David Hervás, Vincent Valentine, Anick N Baca Yepez, Gabriel Olveira, Alexandra L Quittner
BACKGROUND: The Cystic Fibrosis Questionnaire-Revised (CFQ-R+14) is a disease-specific, health-related quality of life instrument for cystic fibrosis (CF) patients ≥14years. We have developed a Spanish electronic version of the CFQ-R (e-CFQ-R+14 Spain). Our aim was to compare the paper and electronic versions and to validate the electronic version. METHODS: Fifty CF patients completed the study. All answered the paper and electronic versions on day 1 and repeated the e-CFQR version 15days later...
November 17, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29157598/chinese-vietnamese-and-asian-indian-parents-perspectives-about-well-child-visits-a-qualitative-analysis
#13
Maya Ragavan, Wendy Li, A Rani Elwy, John Cowden, Megan Bair-Merritt
OBJECTIVES: Well-child visits are a critical component of pediatric healthcare; however, disparities in attendance and quality of care exist for Asian children. Limited research has explored Asian immigrant parents' perspectives about their well-child visit experience. METHODS: Qualitative interviews were conducted with Chinese, Vietnamese, and Asian Indian immigrant parents. Participants were recruited from community-based organizations in the Boston area. Interviews focused on parents' perceptions about well-child visits, including individual attitudes, social and cultural factors impacting their opinions, perceived behavioral control, and improving visits for Asian immigrant families...
November 17, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29157203/survival-time-following-resection-of-intracranial-metastases-from-nsclc-development-and-validation-of-a-novel-nomogram
#14
Xiaoyu Ji, Yingjie Zhuang, Xiangye Yin, Qiong Zhan, Xinli Zhou, Xiaohua Liang
BACKGROUND: Brain metastases (BM) from non-small cell lung cancer (NSCLC) are the most frequent intracranial tumors. To identify patients who might benefit from intracranial surgery, we compared the six existing prognostic indexes(PIs) and built a nomogram to predict the survival for NSCLC with BM before they intended to receive total intracranial resection in China. METHODS: First, clinical data of NSCLC presenting with BM were retrospectively reviewed. All of the patients had received total intracranial resection and were randomly distributed to developing cohort and validation cohort by 2:1...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29154643/gender-nonconformity-of-identical-twins-with-discordant-sexual-orientations-evidence-from-childhood-photographs
#15
Tuesday M Watts, Luke Holmes, Jamie Raines, Sheina Orbell, Gerulf Rieger
Childhood gender nonconformity (femininity in males, masculinity in females) predicts a nonstraight (gay, lesbian, or bisexual) sexual orientation in adulthood. In previous work, nonstraight twins reported more childhood gender nonconformity than their genetically identical, but straight, cotwins. However, self-reports could be biased. We therefore assessed gender nonconformity via ratings of photographs from childhood and adulthood. These ratings came from independent observers naïve to study hypotheses. Identical twins with discordant sexual orientations (24 male pairs, 32 female pairs) visibly differed in their gender nonconformity from mid-childhood, with higher levels of gender nonconformity observed in the nonstraight twins...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29153061/-defining-of-gene-mutations-and-minimal-inhibitory-concentrations-in-isoniazid-resistant-mycobacterium-tuberculosis-isolates
#16
Esra Yıldırım, Meltem Uzun
Tuberculosis is a very important disease all over the world despite the advanced diagnostic and treatment regimens. Resistant tuberculosis, which has increased in recent years in particular, is a global problem and prevents the fight against tuberculosis. For this reason, it is important to determine the etiologic agent early and its sensitivity against antituberculosis drugs. Resistance profiles of the isolates and the gene mutations causing resistance are determined for epidemiological purposes and mutation regions of the isolates are being investigated on the basis of countries...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29152598/study-protocol-a-randomized-controlled-trial-of-a-comprehensive-breast-cancer-treatment-patient-decision-tool-icandecide
#17
Sarah T Hawley, Yun Li, L Alexandra Jeanpierre, Stefanie Goodell, Reshma Jagsi, Kevin C Ward, Michael S Sabel, Steven J Katz
Background: Patients newly diagnosed with breast cancer face a series of complex decisions regarding locoregional and systemic treatment. There is a need to improve the quality of locoregional and systemic decisions for breast cancer patients, and to help patients understand the role of evaluative tests in this decision process. We are now conducting a randomized controlled trial (RCT) of an online decision tool-called iCanDecide, which we expect will help patients with these difficult decisions...
March 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29150249/accuracy-of-the-cobas-egfr-mutation-assay-in-non-small-cell-lung-cancer-compared-with-three-laboratory-developed-tests
#18
Haruhiko Nakamura, Hirotaka Koizumi, Hiroki Sakai, Hiroyuki Kimura, Tomoyuki Miyazawa, Hideki Marushima, Hisashi Saji, Masayuki Takagi
BACKGROUND: The reliability of the cobas EGFR assay to detect epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) as an in vitro diagnostic test was compared with 3 laboratory-developed tests (LDTs). MATERIALS AND METHODS: After screening for EGFR mutations using formalin-fixed-paraffin-embedded NSCLC tissue sections using the cobas EGFR assay, 151 samples were further tested with 3 LDTs; the peptide nucleic acid-locked nucleic acid polymerase chain reaction (PCR) clamp, PCR invader, and Cycleave assays...
October 28, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29148410/th17-gene-expression-in-psoriatic-arthritis-synovial-fluid-and-peripheral-blood-compared-to-osteoarthritis-and-cutaneous-psoriasis
#19
Fatima Abji, Remy A Pollock, Kun Liang, Vinod Chandran, Dafna D Gladman
OBJECTIVES: The IL-23/IL-17 axis is central to the pathogenesis of psoriatic arthritis (PsA). We aimed to identify Th17 signalling genes that are dysregulated in synovial fluid of PsA compared to osteoarthritis (OA) patients and to determine if differences in peripheral blood can distinguish PsA from psoriasis patients and controls. METHODS: Synovial fluid cells (SFCs) from 14 PsA and 9 OA patients were obtained and stored in TRIzol reagent. RNA was isolated by phenol-chloroform extraction and purified with RNeasy miniprep kits...
November 9, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29143666/comparative-evaluation-of-commercially-available-point-of-care-heartworm-antigen-tests-using-well-characterized-canine-plasma-samples
#20
Lindsay A Starkey, Joy V Bowles, Mark E Payton, Byron L Blagburn
BACKGROUND: Dirofilaria immitis is a worldwide parasite that is endemic in many parts of the United States. There are many commercial assays available for the detection of D. immitis antigen, one of which was modified and has reentered the market. Our objective was to compare the recently reintroduced Witness® Heartworm (HW) Antigen test Kit (Zoetis, Florham Park, NJ) and the SNAP® Heartworm RT (IDEXX Laboratories, Inc., Westbrook, ME) to the well-based ELISA DiroChek® Heartworm Antigen Test Kit (Zoetis, Florham Park, NJ)...
November 9, 2017: Parasites & Vectors
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