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https://www.readbyqxmd.com/read/28088800/repeatability-and-reproducibility-of-foveal-avascular-zone-area-measurements-using-angioplex-spectral-domain-optical-coherence-tomography-angiography-in-healthy-subjects
#1
Jiaxian Guo, Xiangjun She, Xiaoying Liu, Xiaodong Sun
PURPOSE: The aim of this study was to evaluate the repeatability and reproducibility of foveal avascular zone (FAZ) area measurements using AngioPlex spectral domain optical coherence tomography (OCT) angiography in normal subjects. METHODS: Twenty-two healthy subjects (25 eyes) underwent FAZ area measurements with AngioPlex OCT. Each volunteer was separately examined 3 consecutive times by the 2 experienced observers. The FAZ area was measured using ImageJ software...
January 14, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28088746/development-of-a-screening-questionnaire-for-dsm-5-intermittent-explosive-disorder-ied-sq
#2
Emil F Coccaro, Mitchell E Berman, Michael S McCloskey
OBJECTIVE: This study was designed to develop and test a screening approach to identify individuals with DSM-5 Intermittent Explosive Disorder (IED), a disorder of recurrent, problematic, impulsive aggression. METHODS: A screening approach to diagnose DSM-5 IED (IED-SQ) was developed by combining items related to life history of aggression and items related to the DSM-5 diagnostic criteria for IED. In study 1, the IED-SQ was studied in 72 adult participants; 33 that met DSM-5 criteria for lifetime IED and 39 that did not...
December 22, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28088238/lymph-node-pooling-a-feasible-and-efficient-method-of-lymph-node-molecular-staging-in-colorectal-carcinoma
#3
Natalia Rakislova, Carla Montironi, Iban Aldecoa, Eva Fernandez, Josep Antoni Bombi, Mireya Jimeno, Francesc Balaguer, Maria Pellise, Antoni Castells, Miriam Cuatrecasas
BACKGROUND: Pathologic lymph node staging is becoming a deficient method in the demanding molecular era. Nevertheless, the use of more sensitive molecular analysis for nodal staging is hampered by its high costs and extensive time requirements. Our aim is to take a step forward in colon cancer (CC) lymph node (LN) pathology diagnosis by proposing a feasible and efficient molecular method in routine practice using reverse transcription loop-mediated isothermal amplification (RT-LAMP). RESULTS: Molecular detection of tumor cytokeratin 19 (CK19) mRNA with RT-LAMP was performed in 3206 LNs from 188 CC patients using two methods: individual analysis of 1449 LNs from 102 patients (individual cohort), and pooled LN analysis of 1757 LNs from 86 patients (pooling cohort)...
January 14, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28087720/a-liminal-stage-after-predictive-testing-for-huntington-disease
#4
Marcela Gargiulo, Sophie Tezenas du Montcel, Marie France Jutras, Ariane Herson, Cecile Cazeneuve, Alexandra Durr
BACKGROUND: Following predictive testing for Huntington disease (HD), knowledge of one's carrier status may have consequences on disease onset. Our study aimed to address two questions. First, does knowledge of being a carrier of the pathological HD mutation trigger onset of the disease? Second, does this knowledge influence self-awareness and allow carriers to identify signs and symptoms of disease onset? METHODS: Between 2012 and 2015, 75 HD mutation carriers were examined using the Unified Huntington's Disease Rating Scale (UHDRS) motor score...
January 13, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28077786/nomogram-analysis-and-external-validation-to-predict-the-risk-of-lymph-node-metastasis-in-gastric-cancer
#5
Shi Chen, Run-Cong Nie, Li-Ying OuYang, Yuan-Fang Li, Jun Xiang, Zhi-Wei Zhou, YingBo Chen, Jun-Sheng Peng
AIM: To identify risk factors for lymph node metastasis using a nomogram for gastric cancer patients to predict lymph node metastasis. RESULTS: The Chi-square test and the logistic regression showed that the Boarrmann type, preoperative CA199 level, T stage and N stage by CT scan were independent risk factors. The concordance index (C-index) was 0.786 in the internal validation of the Nomogram model. In the external validation, the C-index was 0.809, and the AUC was 0...
January 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28077490/improving-uniformity-in-brain-death-determination-policies-over-time
#6
Hilary H Wang, Panayiotis N Varelas, Galen V Henderson, Eelco F M Wijdicks, David M Greer
OBJECTIVE: To demonstrate that progress has been made in unifying brain death determination guidelines in the last decade by directly comparing the policies of the US News and World Report's top 50 ranked neurologic institutions from 2006 and 2015. METHODS: We solicited official hospital guidelines in 2015 from these top 50 institutions, generated summary statistics of their criteria as benchmarked against the American Academy of Neurology Practice Parameters (AANPP) and the comparison 2006 cohort in 5 key categories, and statistically compared the 2 cohorts' compliance with the AANPP...
January 11, 2017: Neurology
https://www.readbyqxmd.com/read/28077147/the-political-and-scientific-challenges-in-evaluating-compulsory-drug-treatment-centers-in-southeast-asia
#7
Thu Vuong, Nhu Nguyen, Giang Le, Marian Shanahan, Robert Ali, Alison Ritter
BACKGROUND: In Vietnam, like many countries in Southeast Asia, the commonly used approach of center-based compulsory drug treatment (CCT) has been criticized on human rights ground. Meanwhile, community-based voluntary methadone maintenance treatment (MMT) has been implemented for nearly a decade with promising results. Reform-minded leaders have been seeking empirical evidence of the costs and effectiveness associated with these two main treatment modalities. Conducting evaluations of these treatments, especially where randomization is not ethical, presents challenges...
January 11, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28077098/validity-of-gestational-age-estimates-by-last-menstrual-period-and-neonatal-examination-compared-to-ultrasound-in-vietnam
#8
Nicholas P Deputy, Phuong H Nguyen, Hoa Pham, Son Nguyen, Lynnette Neufeld, Reynaldo Martorell, Usha Ramakrishnan
BACKGROUND: Accurate estimation of gestational age is important for both clinical and public health purposes. Estimates of gestational age using fetal ultrasound measurements are considered most accurate but are frequently unavailable in low- and middle-income countries. The objective of this study was to assess the validity of last menstrual period and Farr neonatal examination estimates of gestational age, compared to ultrasound estimates, in a large cohort of women in Vietnam. METHODS: Data for this analysis come from a randomized, placebo-controlled micronutrient supplementation trial in Vietnam...
January 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28076494/accuracy-of-mandibular-measurements-of-sexual-dimorphism-using-stabilizer-equipment
#9
Thais Torralbo Lopez, Edgard Michel-Crosato, Eduardo de Novaes Benedicto, Luiz Airton Saavedra de Paiva, Diogo Cesar Borges Silva, Maria Gabriela Haye Biazevic
The objective of this investigation was to compare the accuracy of mandibular measurements using a stabilizer (MS) with gold standard computed tomography (GS) images. Sixty mandibles were studied. Werth TomoScope HV Compact® was used to obtain CT images (GS), and the MS was also used. Analysis of the CT scans was performed using the VG Studio Max software® (Volume Graphics GmbH, Heidelberg, Germany), and MS was used after the proper positioning of the mandible. Descriptive and paired t test measures were used, and a ROC curve was calculated, as well as sensibility and specificity...
January 5, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28076298/comparison-of-abbott-realtime-genotype-ii-genematrix-restriction-fragment-mass-polymorphism-and-sysmex-hiscl-hcv-gr-assays-for-hepatitis-c-virus-genotyping
#10
Mi-Soon Han, Yongjung Park, Hyon-Suk Kim
BACKGROUND: Hepatitis C virus (HCV) genotype is a predictive marker for treatment response. We sequentially evaluated the performances of two nucleic acid amplification tests (NAATs) and one serology assay for HCV genotype: Abbott RealTime genotype II (RealTime II), GeneMatrix restriction fragment mass polymorphism (RFMP), and Sysmex HISCL HCV Gr (HISCL Gr). METHODS: We examined 281 clinical samples with three assays. The accuracy was assessed using the HCV Genotype Performance Panel PHW204 (SeraCare Life Sciences) for two NAATs...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28070204/evaluation-of-lactobacillus-coryniformis-cect5711-strain-as-a-coadjuvant-in-a-vaccination-process-a-randomised-clinical-trial-in-healthy-adults
#11
Noemí Redondo, Esther Nova, Alina Gheorghe, Ligia Esperanza Díaz, Aurora Hernández, Ascensión Marcos
BACKGROUND: Although the effects of probiotics on the immune system have been extensively evaluated under disease states, their role in healthy situations remains unclear, since changes are hardly expected under immunological homeostasis. EFSA indicates that vaccination protocols could be used to evaluate the potential role of probiotics to improve the immune response against antigen challenges. The aim of the study was to evaluate the effect of Lactobacillus coryniformis CECT5711 (Lc) on the specific immunity of healthy volunteers undergoing vaccination with Hepatitis A virus (HAV)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28068926/screening-of-wt1-mutations-in-exon-8-and-9-in-children-with-steroid-resistant-nephrotic-syndrome-from-a-single-centre-and-establishment-of-a-rapid-screening-assay-using-high-resolution-melting-analysis-in-a-clinical-setting
#12
Annes Siji, Varsha Chhotusing Pardeshi, Shilpa Ravindran, Ambily Vasudevan, Anil Vasudevan
BACKGROUND: Mutations in Wilm's tumor 1 (WT1) gene is one of the commonly reported genetic mutations in children with steroid resistant nephrotic syndrome (SRNS). We report the results of direct sequencing of exons 8 and 9 of WT1 gene in 100 children with SRNS from a single centre. We standardized and validated High Resolution Melt (HRM) as a rapid and cost effective screening step to identify individuals with normal sequence and distinguish it from those with a potential mutation. Since only mutation positive samples identified by HRM will be further processed for sequencing it will help in reducing the sequencing burden and speed up the screening process...
January 10, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28067009/one-step-3d-tv-hysterosalpingo-foam-sonography-3d-tv-hyfosy-confirmation-test-for-essure%C3%A2-follow-up-a-multicenter-study
#13
Brunella Zizolfi, Lucia Lazzeri, Mario Franchini, Attilio Di Spiezio Sardo, Carmine Nappi, Emilio Piccione, Caterina Exacoustos
OBJECTIVE: To evaluate the feasibility and accuracy of a three-dimensional-transvaginal-hysterosalpingo-contrast-sonography using the new dedicated contrast-enhanced gel foam (3D-TV-HyFoSy) to assess the position of the tubal sterilization Essure® devices and consequent tubal occlusion in patients who underwent Essure® hysteroscopic tubal sterilization. METHODS: This multicenter study was prospectively conducted from June 2012 to July 2014 in four italian centers and included 50 women who underwent hysteroscopic Essure® microinsert placement, for a total of 95 tubes...
January 9, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28065210/prevalence-of-tuberculosis-infection-in-healthcare-workers-of-the-public-hospital-network-in-medell%C3%A3-n-colombia-a-bayesian-approach
#14
J Ochoa, A L León, I C Ramírez, C M Lopera, E Bernal, M P Arbeláez
A latent tuberculosis infection (LTBI) prevalence survey was conducted using tuberculin skin test (TST) and Quantiferon test (QFT) in 1218 healthcare workers (HCWs) in Medellín, Colombia. In order to improve the prevalence estimates, a latent class model was built using a Bayesian approach with informative priors on the sensitivity and specificity of the TST. The proportion of concordant results (TST+,QFT+) was 41% and the discordant results contributed 27%. The marginal estimate of the prevalence P(LTBI+) was 62·1% [95% credible interval (CrI) 53·0-68·2]...
January 9, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28063787/the-development-and-examination-of-a-new-walking-executive-function-test-for-people-over-50years-of-age
#15
Arturo Leyva, Anoop Balachandran, Jennifer C Britton, Moataz Eltoukhy, Christopher Kuenze, Nicholas D Myers, Joseph F Signorile
A reduction in executive function (EF) performance is a major factor associated with the loss of functional independence among older adults. Computer-based tests are commonly used to evaluate EF; however, these mouse or keyboard tests are upper limb dominant while most activities of daily living (ADL, e.g. crossing a street) are lower limb dominant. The purpose of this study was to examine the utility of a newly developed walking EF test called the Walking Response and Inhibition Test (WRIT). The WRIT was validated by comparing its results a number of established computer-based tests and to an ADL-related test known to require EF, the Timed "Up & Go" Test (TUG)...
January 4, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28063471/comparison-of-assays-for-the-detection-of-west-nile-virus-antibodies-in-equine-serum-after-natural-infection-or-vaccination
#16
REVIEW
Kinga Joó, Tamás Bakonyi, Ottó Szenci, Sára Sárdi, Emőke Ferenczi, Mónika Barna, Péter Malik, Zdenek Hubalek, Orsolya Fehér, Orsolya Kutasi
West Nile virus (WNV) mainly infects birds, horses and humans. Outcomes of the infection range from mild uncharacteristic signs to fatal neurologic disease. The main objectives of the present study were to measure serum IgG and IgM antibodies in naturally exposed and vaccinated horses and to compare results of haemagglutination inhibition test (HIT), enzyme-linked immunosorbent assay (ELISA) and plaque reduction neutralisation test (PRNT). Altogether 224 animals were tested by HIT for WNV antibodies and 41 horses were simultaneously examined by ELISA and PRNT...
January 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28063108/validation-of-18-f-fdg-pet-single-subject-optimized-spm-procedure-with-different-pet-scanners
#17
Luca Presotto, Tommaso Ballarini, Silvia Paola Caminiti, Valentino Bettinardi, Luigi Gianolli, Daniela Perani
(18)F-fluoro-deoxy-glucose Positron Emission Tomography (FDG-PET) allows early identification of neurodegeneration in dementia. The use of an optimized method based on the SPM software package highly improves diagnostic accuracy. However, the impact of different scanners for data acquisition on the SPM results and the effects of different pools of healthy subjects on the statistical comparison have not been investigated yet. Images from 144 AD patients acquired using six different PET scanners were analysed with an optimized single-subject SPM procedure to identify the typical AD hypometabolism pattern at single subject level...
January 6, 2017: Neuroinformatics
https://www.readbyqxmd.com/read/28063000/evaluation-of-loop-mediated-isothermal-amplification-for-the-rapid-identification-of-bacteria-and-resistance-determinants-in-positive-blood-cultures
#18
J Rödel, J A Bohnert, S Stoll, L Wassill, B Edel, M Karrasch, B Löffler, W Pfister
The use of molecular assays to rapidly identify pathogens and resistance genes directly from positive blood cultures (BCs) contribute to shortening the time required for the diagnosis of bloodstream infections. In this work, loop-mediated isothermal amplification (LAMP) assays have been examined for their potential use in BC diagnosis. Three different assays were applied. The commercially available eazyplex® MRSA test detects Staphylococcus aureus, S. epidermidis, mecA, and mecC. Two in-house assays [Gram-positive (GP) and Gram-negative (GN)] have been developed for the detection of streptococci, enterococci, vanA, vanB, Pseudomonas spp...
January 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28062215/next-generation-sequencing-in-adult-b-cell-acute-lymphoblastic-leukemia-patients
#19
Olga Sala Torra, Megan Othus, David W Williamson, Brent Wood, Ilan Kirsch, Harlan Robins, Lan Beppu, Margaret R O'Donnell, Stephen J Forman, Frederick R Appelbaum, Jerald P Radich
We used next generation sequencing (NGS) of the immunoglobulin genes to evaluate residual disease in 153 specimens from 32 patients with adult B cell ALL enrolled in a single, multi-center study. The sequencing results were compared to multi-parameter flow cytometry (MFC) data in 66 specimens (25 patients) analyzed by both methods. There was a strong concordance (82%) between the methods in the qualitative determination of the presence of disease. However, in 17% of cases leukemia was detected by sequencing, but not by MFC...
January 3, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28061826/monophylogenetic-hiv-1c-epidemic-in-ethiopia-is-dominated-by-ccr5-tropic-viruses-an-analysis-of-a-prospective-country-wide-cohort
#20
Amare Worku Kalu, Nigus Fikrie Telele, Solomon Gebreselasie, Daniel Fekade, Samir Abdurahman, Gaetano Marrone, Anders Sönnerborg
BACKGROUND: CCR5 coreceptor using HIV-1 subtype C (HIV-1C) has been reported to dominate the Ethiopian epidemic. However, almost all data have been obtained from two large cities in the central and north-west regions and recent data is lacking. METHODS: Plasma were obtained from 420 treatment-naïve patients recruited 2009-2011 to a large country-wide Ethiopian cohort. The V3 region was sequenced and the co-receptor tropism was predicted by the clinical and clonal models of the geno2pheno tool at different false positive rates (fpr) and for subtype...
January 6, 2017: BMC Infectious Diseases
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