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https://www.readbyqxmd.com/read/29908431/smoking-ban-and-health-at-birth-evidence-from-hungary
#1
Tamás Hajdu, Gábor Hajdu
In 2012, smoking restrictions were extended to hospitality venues in Hungary. Women working in bars and restaurants were primarily affected by the intervention. In this research, we analyze the effect of this smoking ban on the outcomes of their pregnancies. Using individual live birth, fetal loss, and infant mortality registry data, we examine the probability of live birth, indicators of health at birth, and the probability of death in the first year of life. We apply a difference-in-differences framework and show that the smoking ban has improved health at birth...
June 13, 2018: Economics and Human Biology
https://www.readbyqxmd.com/read/29907804/administration-of-molecular-hydrogen-during-pregnancy-improves-behavioral-abnormalities-of-offspring-in-a-maternal-immune-activation-model
#2
Kenji Imai, Tomomi Kotani, Hiroyuki Tsuda, Tomoko Nakano, Takafumi Ushida, Akira Iwase, Taku Nagai, Shinya Toyokuni, Akio Suzumura, Fumitaka Kikkawa
The aim of the present study was to investigate long-term outcomes of the offspring in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) model and the effect of maternal molecular hydrogen (H2 ) administration. We have previously demonstrated in the MIA mouse model that maternal administration of H2 attenuates oxidative damage and neuroinflammation, including induced pro-inflammatory cytokines and microglial activation, in the fetal brain. Short-term memory, sociability and social novelty, and sensorimotor gating were evaluated using the Y-maze, three-chamber, and prepulse inhibition (PPI) tests, respectively, at postnatal 3 or 4 weeks...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902902/-effect-and-mechanism-of-yunkang-oral-liquid-in-regulating-endocrine-system-and-vegf-signaling-pathway-and-reducing-abortion-rate-in-recurrent-abortion-mice
#3
Bo Chen, Qiu-Qiu Shi, Kai-Lun Liang, Yu-Yue Xu, Ying-Ying Fang, Su-Hong Chen, Gui-Yuan Lyu
This experiment focuses on the effect of Yunkang oral liquid on abortion rate, endocrine system and VEGF signal pathway in Clark classical recurrent abortion model mice. RSA mice were randomly divded into model group, low, middle and high-dose groups and progesterone group. The normal pregnancy mice were included into normal group. Since the first day of pregnancy, the normal group and the RSA model group were given the same dose of distilled water, while low, middle and high-dose groups were given Yunkang oral liquid at the dose of 9, 18, 36 mL·kg¹·d⁻¹; progesterone group were given progesterone by 0...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29901012/prognosis-in-pregnant-females-with-systemic-lupus-erythematosus
#4
Enling Liu, Yuxiu Zhou
Objectives: This study aims to analyze the relationship between pregnancy and lupus, and explore the risk factors that adversely affect maternal and infant outcomes. Patients and methods: The pregnancy outcomes in 112 pregnant females (mean age 24.3±2.8 years; range 20 to 35 years) with systemic lupus erythematosus (SLE) were retrospectively analyzed. Pregnancy outcomes before and after pregnancy were compared, and the associations with lupus nephritis, positive anti-Ro/SSA antibody, positive La/SSB antibody, complement 3 and complement 4, high blood pressure, positive anti- cardiolipin (aCL) antibody, Raynaud's phenomenon, and lupus recurrence were evaluated...
December 2017: Archives of Rheumatology
https://www.readbyqxmd.com/read/29899331/placental-exosome-mediated-bta-mir-499-lin28b-let-7-axis-regulates-inflammatory-bias-during-early-pregnancy
#5
Gan Zhao, Chao Yang, Jing Yang, Pei Liu, Kangfeng Jiang, Aftab Shaukat, Haichong Wu, Ganzhen Deng
Abnormal inflammatory bias in the maternal-fetal interface leads to reproductive failure in mammals. Placental exosomes are involved in maternal-fetal communication during pregnancy. However, whether the placenta or fetus is involved in regulating the balance of uterine local inflammation through exosomes remains unclear, and the mechanism must be further explored. Here we demonstrated that placenta-specific exosomes are abundant in the peripheral blood of dairy cows during early pregnancy and selectively load miRNAs, such as bta-miR-499...
June 13, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29895300/papp-a2-deficiency-does-not-exacerbate-the-phenotype-of-a-mouse-model-of-intrauterine-growth-restriction
#6
Julian K Christians, Kendra I Lennie, Maria F Huicochea Munoz, Nimrat Binning
BACKGROUND: Pregnancy-associated plasma protein-A2 (PAPP-A2) is consistently upregulated in the placentae of pregnancies complicated by preeclampsia and fetal growth restriction. The causes and significance of this upregulation remain unknown, but it has been hypothesized that it is a compensatory response to improve placental growth and development. We predicted that, if the upregulation of PAPP-A2 in pregnancy complications reflects a compensatory response, then deletion of Pappa2 in mice would exacerbate the effects of a gene deletion previously reported to impair placental development: deficiency of matrix metalloproteinase-9 (MMP9)...
June 12, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29894515/tolerogenic-%C3%AE-2-glycoprotein-i-dna-vaccine-and-fk506-as-an-adjuvant-attenuates-experimental-obstetric-antiphospholipid-syndrome
#7
Ya-Hsuan Chao, Der-Yuan Chen, Joung-Liang Lan, Kuo-Tung Tang, Chi-Chien Lin
DNA vaccines have recently emerged as a therapeutic agent for treating autoimmune diseases, such as multiple sclerosis. Antiphospholipid antibody syndrome (APS) is an autoimmune disease characterized by β2-glycoprotein I (β2-GPI)-targeting antiphospholipid antibodies (APAs) and vascular thrombosis or obstetrical complications. To examine the therapeutic potential of a β2-GPI DNA vaccine, we administered a vaccine mixed with FK506 as an adjuvant to a mouse model of obstetric APS. First, the pCMV3-β2-GPI DNA vaccine, which encodes the full-length human β2-GPI gene, was constructed...
2018: PloS One
https://www.readbyqxmd.com/read/29891914/obstetric-and-vascular-antiphospholipid-syndrome-same-antibodies-but-different-diseases
#8
REVIEW
Pier Luigi Meroni, Maria Orietta Borghi, Claudia Grossi, Cecilia Beatrice Chighizola, Paolo Durigutto, Francesco Tedesco
Recurrent thrombosis and miscarriages are the main clinical manifestations of antiphospholipid syndrome (APS). Although most patients display both clinical signs, some patients can have isolated vascular or obstetric variants. Emerging data raise the question of whether obstetric and vascular APS are the same or different diseases. An important difference between the two conditions is that a thrombophilic state is a common feature in vascular APS, whereas clot occlusions of the decidual spiral arteries are seldom observed in obstetric APS, and infarctions are found in only one-third of APS placentae...
June 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29889640/cost-of-retained-fetal-membranes-for-dairy-herds-in-the-united-states
#9
Khaled Gohary, Stephen J LeBlanc
OBJECTIVE To estimate the cost of a case of retained fetal membranes (RFM) for dairy herds in the United States. DESIGN Deterministic computer-based spreadsheet analysis. SAMPLE Inputs from published studies and reports. PROCEDURES Economic losses attributable to RFM were direct (reduction in milk yield and longer interval until pregnancy) and indirect (increased risk of developing clinical disease and increased culling risk). Cost attributable to milk loss was calculated as the mean marginal loss of milk production for cows with RFM and cows with RFM complicated by metritis...
June 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29884740/metformin-induces-foxo3-dependent-fetal-hemoglobin-production-in-human-primary-erythroid-cells
#10
Yankai Zhang, Alireza Paikari, Pavel Sumazin, Carly C Ginter Summarell, Jacy R Crosby, Eric Boerwinkle, Mitchell J Weiss, Vivien A Sheehan
Induction of red blood cell fetal hemoglobin (HbF, α2γ2) ameliorates the pathophysiology of sickle cell disease (SCD) by reducing the concentration of sickle hemoglobin (HbS, α2βS 2) to inhibit its polymerization. Hydroxyurea (HU), the only FDA-approved drug for SCD, acts in part by inducing HbF, but is not fully effective, reflecting the need for new therapies. Whole exome sequence analysis of rare genetic variants in SCD patients identified FOXO3 as a candidate regulator of RBC HbF. We validated these genomic findings through loss and gain of function studies in normal human CD34+ hematopoietic stem and progenitor cells (HSPCs) induced to undergo erythroid differentiation...
June 8, 2018: Blood
https://www.readbyqxmd.com/read/29884513/acquired-antibodies-to-%C3%AE-iib%C3%AE-3-in-glanzmann-thrombasthenia-from-transfusion-and-pregnancy-to-bone-marrow-transplants-and-beyond
#11
REVIEW
Alan T Nurden
Patients with the inherited bleeding disorder Glanzmann thrombasthenia (GT) possess platelets that lack αIIbβ3 integrin and fail to aggregate, and have moderate to severe mucocutaneous bleeding. Many become refractory to platelet transfusions due to the formation of isoantibodies to αIIbβ3 with the rapid elimination of donor platelets and/or a block of function. Epitope characterization has shown isoantibodies to be polyclonal and to recognize different epitopes on the integrin with β3 a major site and αvβ3 on endothelial and vascular cells a newly recognized target...
May 23, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29882091/mthfr-isoform-carriers-5-mthf-5-methyl-tetrahydrofolate-vs-folic-acid-a-key-to-pregnancy-outcome-a-case-series
#12
Edouard J Servy, Laetitia Jacquesson-Fournols, Marc Cohen, Yves J R Menezo
PURPOSE: To evaluate the possibility of correcting metabolic defects in gametes and embryos due to methylene tetra hydrofolate reductase (MTHFR) isoforms C677T and A1298C, by supplementation with 5-methyl THF instead of synthetic folic acid. In these couples, high doses of folic acid lead to UMFA (un-metabolized folic acid) syndrome. METHODS: Thirty couples with fertility problems lasting for at least 4 years, such as recurrent fetal loss, premature ovarian insufficiency, or abnormal sperm parameters, with two thirds of them having failed assisted reproductive technology (ART) attempts were included in this program...
June 7, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29880704/paracetamol-acetaminophen-during-pregnancy-induces-prenatal-ductus-arteriosus-closure
#13
Odile Becquet, Damien Bonnet, Yves Ville, Karel Allegaert, Alexandre Lapillonne
Paracetamol or acetaminophen (APAP) is commonly used as a first line treatment of pain and fever in pregnancy. In view of new evidence that reveals that APAP medication during pregnancy may be associated with impaired outcomes, safety of the use of APAP during pregnancy should be questioned. The causality between maternal APAP treatment and prenatal ductus arteriosus closure was qualified as certain by using the World Health Organization Uppsala Monitoring Center causality assessment system in a short series of 2 clinical cases...
June 7, 2018: Pediatrics
https://www.readbyqxmd.com/read/29880371/long-term-effects-of-pregnancy-on-renal-graft-function-in-women-after-kidney-transplantation-compared-with-matched-controls
#14
S Svetitsky, R Baruch, I F Schwartz, D Schwartz, R Nakache, Y Goykhman, P Katz, A Grupper
BACKGROUND: An important benefit associated with kidney transplantation in women of child-bearing age is increased fertility. We retrospectively evaluated the maternal and fetal complications and evolution of graft function associated with 22 pregnancies post-kidney and kidney-pancreas transplantation, compared with controls without pregnancy post-transplantation, who were matched for gender, year of transplantation, type of donor, age at transplantation, number of transplants, type of transplant (kidney vs kidney-pancreas), and cause of native kidney failure, as well as for renal parameters including serum creatinine and urine protein excretion 1 year before delivery...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29880163/effect-of-twin-pregnancy-chorionic-properties-on-maternal-and-fetal-outcomes
#15
Bibo Feng, Jianjun Zhai, Yu Cai
OBJECTIVE: This study aimed to determine the effect of twin pregnancy chorionic properties on pregnancy complications and fetal outcomes. MATERIALS AND METHODS: A total of 559 subjects with gemellary pregnancy were included in the retrospective analysis, and clinical data, such as monitoring data during pregnancy and maternal and fetal outcomes, were recorded in detail. Based on the ultrasound results and methods of the postpartum pathologic examination of the placental membranes, the subjects were divided into the twin group with monochorionic diamnion (MCDA group, n = 198) and twin group with dichorionic diamnion (DCDA group, n = 361)...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29879927/arterial-venous-thrombosis-fetal-loss-and-stillbirth-in-pregnant-women-with-systemic-lupus-erythematosus-versus-primary-and-secondary-antiphospholipid-syndrome-a-systematic-review-and-meta-analysis
#16
Pravesh Kumar Bundhun, Mohammad Zafooruddin Sani Soogund, Feng Huang
BACKGROUND: We aimed to systematically compare arterial/venous thrombosis, fetal loss and stillbirth in pregnant women with systemic lupus erythematosus (SLE), primary anti-phospholipid syndrome (PAPS) and secondary anti-phospholipid syndrome (SAPS). METHODS: Online databases were carefully searched for relevant publications comparing SLE with PAPS and/or SAPS in pregnancy. Studies were included if: they compared SLE with APS [SLE versus PAPS or SLE versus SAPS or SLE versus PAPS and SAPS respectively] in pregnant women; and they reported specific adverse outcomes as their clinical endpoints including arterial/venous thrombosis, fetal loss and stillbirth...
June 7, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29874535/mifepristone-pretreatment-for-the-medical-management-of-early-pregnancy-loss
#17
Courtney A Schreiber, Mitchell D Creinin, Jessica Atrio, Sarita Sonalkar, Sarah J Ratcliffe, Kurt T Barnhart
BACKGROUND: Medical management of early pregnancy loss is an alternative to uterine aspiration, but standard medical treatment with misoprostol commonly results in treatment failure. We compared the efficacy and safety of pretreatment with mifepristone followed by treatment with misoprostol with the efficacy and safety of misoprostol use alone for the management of early pregnancy loss. METHODS: We randomly assigned 300 women who had an anembryonic gestation or in whom embryonic or fetal death was confirmed to receive pretreatment with 200 mg of mifepristone, administered orally, followed by 800 μg of misoprostol, administered vaginally (mifepristone-pretreatment group), or 800 μg of misoprostol alone, administered vaginally (misoprostol-alone group)...
June 7, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29872333/achondrogenesis-type-1a-clinical-histologic-molecular-and-prenatal-ultrasound-diagnosis
#18
Sara Vanegas, Luz Fernanda Sua, Jaime López-Tenorio, Diana Ramírez-Montaño, Harry Pachajoa
Background: Achondrogenesis type IA (ACG1A) is a rare, lethal autosomal recessive chondrodysplasia affecting endochondral bone ossification and differentiation, causing intrauterine growth restriction, narrow thorax, and short limbs. Mutations in TRIP11 , which encodes Golgi microtubule-binding protein 210 in the Golgi apparatus, alter protein transport in tissues. Case presentation: A 28-week gestation male fetus was diagnosed with ACG1A by clinical, radiological, histologic, and molecular findings...
2018: Application of Clinical Genetics
https://www.readbyqxmd.com/read/29871515/dual-effects-of-human-placenta-derived-neural-cells-on-neuroprotection-and-the-inhibition-of-neuroinflammation-in-a-rodent-model-of-parkinson-s-disease
#19
Han Wool Kim, Hyun-Seob Lee, Jun Mo Kang, Sang-Hun Bae, Chul Kim, Sang-Hun Lee, Johannes Schwarz, Gi Jin Kim, Jin-Su Kim, Dong Hyun Cha, Joopyung Kim, Sung Woon Chang, Tae Hee Lee, Jisook Moon
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease in the elderly and the patients suffer from uncontrolled movement disorders due to loss of dopaminergic (DA) neurons on substantia nigra pars compacta (SNpc). We previously reported that transplantation of human fetal midbrain-derived neural precursor cells restored the functional deficits of a 6-hydroxy dopamine (6-OHDA)-treated rodent model of PD but its low viability and ethical issues still remain to be solved. Albeit immune privilege and neural differentiation potentials suggest mesenchymal stem cells (MSCs) from various tissues including human placenta MSCs (hpMSCs) for an alternative source, our understanding of their therapeutic mechanisms is still limited...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29870394/abnormally-invasive-placenta-aip-pre-cesarean-amnion-drainage-to-facilitate-exteriorization-of-the-gravid-uterus-through-a-transverse-skin-incision
#20
Thorsten Braun, Katharina Weizsäcker, Mustafa Zelal Muallem, Janina Tillinger, Larry Hinkson, Frederic Chantraine, Wolfgang Henrich
The number of pregnant women with abnormally invasive placenta (AIP) including clinical relevant placenta increta and percreta has markedly increased with a reported incidence of as high as one in 731, By 2020 in the United States, there will be an estimated 4504 new cases of AIP and 130 AIP-associated maternal deaths annually. The preoperative diagnosis and operative management of AIP is challenging. In a planned cesarean delivery, a vertical lower abdominal skin incision is widely used in order to have enough space to perform a hysterotomy above the cranial edge of the placenta to avoid significant fetal and/or maternal hemorrhage...
June 5, 2018: Journal of Perinatal Medicine
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