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Fetal loss

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https://www.readbyqxmd.com/read/29453792/impact-of-tsh-during-the-first-trimester-of-pregnancy-on-obstetric-and-fetal-complications-usefulness-of-2-5-miu-l-cut-off-value
#1
Marta Hernández, Carolina López, Berta Soldevila, Laura Cecenarro, María Martínez-Barahona, Elisabet Palomera, Ferran Rius, Albert Lecube, Maria José Pelegay, Jordi García, Dídac Mauricio, Manel Puig Domingo
OBJECTIVE: An association of pregnancy outcomes with subclinical hypothyroidism has been reported, however there still exists a strong controversy regarding whether subclinical hypothyroidism ought to be dealt with or not. The objective of the study was to evaluate the association of fetal-maternal complications with first trimester maternal TSH values. DESIGN: A retrospective study in a single tertiary care hospital was performed. PATIENTS: 1981 pregnant women were studied during 2012...
February 17, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29450694/characteristics-of-women-with-mixed-mass-formation-after-evacuation-following-uterine-artery-chemoembolization-for-cesarean-scar-pregnancy
#2
Qiu-Lei Sun, Xiao-Hua Wu, Li Luo, De-Mei Ying, Ying Yang, Zheng-Qiong Chen
PURPOSE: To explore the efficacy of treatment for early cesarean scar pregnancy (CSP) and to evaluate the characteristics of women with subsequent mixed mass formation. METHODS: Women with CSP, who received UACE followed by evacuation, were retrospectively analyzed. Clinical/sonographic characteristics in patients with or without mixed mass formation were compared. RESULTS: From a total of 395 cases, 105 cases had a pregnancy residual with mixed mass formation...
February 15, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29447718/no-240-cytomegalovirus-infection-in-pregnancy
#3
Yoav Yinon, Dan Farine, Mark H Yudin
OBJECTIVES: To review the principles of prenatal diagnosis of congenital cytomegalovirus (CMV) infection and to describe the outcomes of the affected pregnancies. OUTCOMES: Effective management of fetal infection following primary and secondary maternal CMV infection during pregnancy. Neonatal signs include intrauterine growth restriction (IUGR), microcephaly, hepatosplenomegaly, petechiae, jaundice, chorioretinitis, thrombocytopenia and anemia, and long-term sequelae consist of sensorineural hearing loss, mental retardation, delay of psychomotor development, and visual impairment...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29444799/salvage-from-cervical-dystocia-in-third-degree-uterovaginal-prolapse-duhrssen-s-incision
#4
Manju Lata Verma, Vartika Tripathi, Uma Singh, Zakia Rahman
We present a case of a 28-year-old woman second gravida with a full-term pregnancy who presented to us in active phase of labour with third degree uterovaginal prolapse complicated by entrapment of fetal head by dystocia of cervix and fetal distress. Patient was immediately shifted to the operation theatre and prompt delivery was conducted by giving Duhrssen's incision on the highly vascular, oedematous prolapsed cervix. The outcome was an alive and healthy male baby. Duhrssen's incision was stitched with minimal blood loss...
February 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29443736/what-may-cause-fetus-loss-from-acute-pancreatitis-in-pregnancy-analysis-of-54-cases
#5
Min Tang, Jian-Ming Xu, Sha-Sha Song, Qiao Mei, Li-Jiu Zhang
Acute pancreatitis in pregnancy (APIP) poses a serious threat to the mother and her fetus, and might lead to fetal loss including miscarriage and stillbirth in certain patients. We sought to identify possible factors that affect fetal distress and evaluated outcomes of patients with APIP.We retrospectively reviewed clinical records of 54 pregnant women with APIP, who were treated at 2 tertiary clinical centers over a 6-year period. Clinical characteristics including etiology and severity of APIP, fetal monitoring data, and maternofetal outcomes were analyzed...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29440752/one-step-noninvasive-prenatal-testing-nipt-for-autosomal-recessive-homozygous-point-mutations-using-digital-pcr
#6
Mun Young Chang, Soyeon Ahn, Min Young Kim, Jin Hee Han, Hye-Rim Park, Han Kyu Seo, Jinsun Yoon, Seungmin Lee, Doo-Yi Oh, Changsoo Kang, Byung Yoon Choi
Previously, we introduced a noninvasive prenatal testing (NIPT) protocol for diagnosing compound heterozygous autosomal recessive point mutations via maternal plasma DNA and simulated control genomic DNA sampling based on fetal DNA fraction. In our present study, we have improved our NIPT protocol to make it possible to diagnose homozygous autosomal recessive point mutations without the need to acquire fetal DNA fraction. Moreover, chi-squared test and empirical statistical range based on the proportion of mutant allele reads among the total reads served as the gatekeeping method...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439677/trajectory-of-vitamin-d-status-during-pregnancy-in-relation-to-neonatal-birth-size-and-fetal-survival-a-prospective-cohort-study
#7
Linnea Bärebring, Maria Bullarbo, Anna Glantz, Lena Hulthén, Joy Ellis, Åse Jagner, Inez Schoenmakers, Anna Winkvist, Hanna Augustin
BACKGROUND: We investigated the associations between vitamin D status in early and late pregnancy with neonatal small for gestational age (SGA), low birth weight (LBW) and preterm delivery. Furthermore, associations between vitamin D status and pregnancy loss were studied. METHODS: Serum 25-hydroxyvitamin D (25OHD) was sampled in gestational week ≤ 16 (trimester 1 (T1), N = 2046) and > 31 (trimester 3 (T3), N = 1816) and analysed using liquid chromatography tandem mass spectrometry...
February 13, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29428904/developmental-disorder-of-podocytes-and-the-related-renal-diseases
#8
Ya-Nan Zhu, Ying Ao, Bin Li, Yang Wan, Hui Wang
Podocyte is one of the main components of glomerular filtration barrier in the kidney; the loss or dysfunction of podocyte could impair the functions of glomerular filtration barrier, leading to development of various renal diseases. Podocyte is a terminally differentiated cell, and thus does not possess any proliferative properties. Accordingly, its number and contribution to renal function are initially determined by its normal development. Information from the literature and results of our research indicate that genetic factors or prenatal adverse environment could cause developmental retardation of podocytes, thereby suggesting the potential fetal developmental origin(s) of kidney diseases, and involvement of epigenetic mechanisms in the regulation of key genes in podocyte development...
February 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29420836/morphology-of-early-intrauterine-deaths-with-full-trisomy-15
#9
Tom Philipp, Jefferson Terry, Michael Feichtinger, Sandra Grillenberger, Beda Hartmann, Stefan Jirecek
OBJECTIVE: The morphologic features of embryos with full trisomy 15 are described. METHOD: 1195 pregnancy losses were examined embryoscopically and cytogenetically. RESULTS: Of 1173 successfully karyotyped specimens, full trisomy 15 was diagnosed cytogenetically in 59 cases (5 %). All 59 trisomy 15 embryos were diagnosed cytogenetically in the group of 962 embryonic miscarriages (6%). Trisomy 15 was not registered in 171 anembryonic or yolk sac miscarriages, and no case of full trisomy 15 was observed in 62 fetal miscarriages...
February 8, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29419693/organ-damage-mitigation-with-the-baskent-sickle-cell-medical-care-development-program-bascare
#10
Hakan Ozdogu, Can Boga, Suheyl Asma, Ilknur Kozanoglu, Cigdem Gereklioglu, Mahmut Yeral, Nurhilal Turgut Buyukkurt, Soner Solmaz, Aslı Korur, Pelin Aytan, Erkan Maytalman, Mutlu Kasar
The Eastern Mediterranean is among the regions where sickle cell disease (SCD) is common. The morbidity and mortality of this disease can be postponed to adulthood through therapies implemented in childhood. The present study focuses on the organ damage-reducing effects of the Baskent Sickle Cell Medical Care Development Program (BASCARE), which was developed by a team who lives in this region and has approximately 25 years of experience. The deliverables of the program included the development of an electronic health recording system (PRANA) and electronic vaccination system; the use of low citrate infusion in routine prophylactic automatic erythrocyte exchange (ARCE) programs including pregnant women; the use of leukocyte-filtered and irradiated blood for transfusion; the use of magnetic resonance imaging methods (T2) for the management of transfusion-related hemosiderosis; and the implementation of an allogeneic hematopoietic stem cell transplantation protocol for adult patients...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29418029/procedural-and-obstetrical-outcomes-after-embryo-reduction-or-fetal-reduction-in-multifetal-pregnancies-a-retrospective-study
#11
Mi Sun Kim, Dong Hee Choi, Hwang Kwon, Eunhee Ahn, Hee Young Cho, Min Jung Baek, Ji Eun Shin, Myoung Jin Moon
OBJECTIVES: Few studies have compared embryo reduction (ER) and fetal reduction (FR) for multifetal pregnancy reduction (MPR). This study investigated the procedure-related adverse events and the obstetrical outcomes in women with multifetal pregnancies (MPs) in whom MPRs to twins or a single fetus were performed at different gestational ages. METHODS: We retrospectively analyzed the data from MPs on which transvaginal ER (n = 181) at a mean gestational age of 7...
February 8, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29416874/optimization-of-commercially-available-zika-virus-antibodies-for-use-in-a-laboratory-developed-immunohistochemical-assay
#12
Brigid C Bollweg, Luciana Silva-Flannery, Pamela Spivey, Gillian L Hale
Zika virus (ZIKV) infection during pregnancy can cause adverse fetal outcomes and severe irreversible congenital birth defects including microcephaly. Immunohistochemistry (IHC) is a valuable diagnostic tool for detecting ZIKV antigens in tissues from cases of fetal loss in women infected with ZIKV, and for providing insights into disease pathogenesis. As a result, there is increasing demand for commercially available ZIKV antibodies for use in IHC assays. ZIKV antibodies were selected and obtained from commercial sources to include both mouse and rabbit hosts, and a variety of antigenic targets...
January 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29413892/mechanisms-of-cortical-differentiation
#13
Lata Adnani, Sisu Han, Saiqun Li, Pierre Mattar, Carol Schuurmans
During fetal and postnatal development, the human brain generates 160 billion neuronal and glial cells, each with precise cellular phenotypes. To effectively manage such a complicated task, intrinsic (e.g., transcription factors) and extrinsic (environmental signals) cues cooperate to regulate the decision by neural progenitors to continue to proliferate or to differentiate. Loss- and gain-of-function studies in the mouse brain have been instrumental in identifying these cues, leading to a fairly well-developed and well-integrated model of neocortical development...
2018: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/29410108/post-mortem-microfocus-computed-tomography-for-early-gestation-fetuses-a-validation-study-against-conventional-autopsy
#14
John C Hutchinson, Xin Kang, Susan Cheng Shelmerdine, Valerie Segers, Claudio M Lombardi, Mieke M Cannie, Neil J Sebire, Jacques C Jani, Owen J Arthurs
BACKGROUND: Perinatal autopsy provides useful clinical information in up to 40% of cases. However, there is a substantial unmet clinical need with regards to post mortem investigation of early gestation fetal loss for parents for whom standard autopsy is either not available or not acceptable. Parents dislike the invasive nature of autopsy, but current clinical imaging techniques do not provide high-enough imaging resolution in small fetuses. We hypothesized that microfocus computed tomography, a rapid, high resolution imaging technique, could give accurate diagnostic imaging following early gestation fetal loss...
January 31, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29409911/inhibition-of-gingipains-prevents-porphyromonas-gingivalis-induced-preterm-birth-and-fetal-death-in-pregnant-mice
#15
Ryosuke Takii, Tomoko Kadowaki, Takayuki Tsukuba, Kenji Yamamoto
Accumulating epidemiological evidence indicates that infection with Porphyromonas gingivalis which is a major periodontal pathogen, causes preterm birth and low birth weight. However, virulence factors of P. gingivalis responsible for preterm birth/low birth weight remain to be elucidated. In this study, using P. gingivalis-infected pregnant mice as an in vivo model, we investigated whether gingipains-cysteine proteinases produced by P. gingivalis-affect preterm birth and low birth weight. We found that intravenous infection of pregnant mice with P...
February 6, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29408962/ibuprofen-is-deleterious-for-the-development-of-first-trimester-human-fetal-ovary-ex-vivo
#16
S Leverrier-Penna, R T Mitchell, E Becker, L Lecante, M Ben Maamar, N Homer, V Lavoué, D M Kristensen, N Dejucq-Rainsford, B Jégou, S Mazaud-Guittot
STUDY QUESTION: Does ibuprofen use during the first trimester of pregnancy interfere with the development of the human fetal ovary? SUMMARY ANSWER: In human fetuses, ibuprofen exposure is deleterious for ovarian germ cells. WHAT IS KNOWN ALREADY: In utero stages of ovarian development define the future reproductive capacity of a woman. In rodents, analgesics can impair the development of the fetal ovary leading to early onset of fertility failure...
February 2, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29408475/optimal-route-of-diphtheria-toxin-administration-to-eliminate-native-nephron-progenitor-cells-in-vivo-for-kidney-regeneration
#17
Shohei Fukunaga, Shuichiro Yamanaka, Toshinari Fujimoto, Susumu Tajiri, Taketo Uchiyama, Kei Matsumoto, Takafumi Ito, Kazuaki Tanabe, Takashi Yokoo
To address the lack of organs for transplantation, we previously developed a method for organ regeneration in which nephron progenitor cell (NPC) replacement is performed via the diphtheria toxin receptor (DTR) system. In transgenic mice with NPC-specific expression of DTR, NPCs were eliminated by DT and replaced with NPCs lacking the DTR with the ability to differentiate into nephrons. However, this method has only been verified in vitro. For applications to natural models, such as animal fetuses, it is necessary to determine the optimal administration route and dose of DT...
January 30, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29408281/tumor-suppressor-btg1-limits-activation-of-bcl6-expression-downstream-of-etv6-runx1
#18
Esther Tijchon, Liesbeth van Emst, Laurensia Yuniati, Dorette van Ingen Schenau, Mylène Gerritsen, Laurens T van der Meer, Owen Williams, Peter M Hoogerbrugge, Blanca Scheijen, Frank N van Leeuwen
Translocation t(12;21) (p13;q22), giving rise to the ETV6-RUNX1 fusion gene, is the most common genetic abnormality in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). This translocation usually arises in utero, but its expression is insufficient to induce leukemia and requires other cooperating genetic lesions for BCP-ALL to develop. Deletions affecting the transcriptional coregulator BTG1 are frequently observed in ETV6-RUNX1-positive leukemia. Here we show that Btg1 deficiency enhances the self-renewal capacity of ETV6-RUNX1 positive mouse fetal liver derived hematopoietic progenitors (FL-HPCs)...
February 2, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29406288/emotional-effect-of-the-loss-of-one-or-both-fetuses-in-a-monochorionic-twin-pregnancy
#19
Mònica Druguet, Laura Nuño, Carlota Rodó, Silvia Arévalo, Elena Carreras, Juana Gómez-Benito
OBJECTIVE: To examine the psychological effect on women of the loss of one or both fetuses during a monochorionic twin pregnancy and to identify associated protective and risk factors. DESIGN: Descriptive, cross-sectional, correlational study. SETTING: Maternity unit of the Vall d'Hebron University Hospital in Barcelona, Spain. PARTICIPANTS: Twenty-eight White Spanish women who lost one or both fetuses during a monochorionic twin pregnancy...
January 31, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29402304/comprehensive-characterization-of-chorionic-villi-derived-mesenchymal-stromal-cells-from-human-placenta
#20
Mónica S Ventura Ferreira, Michaela Bienert, Katrin Müller, Björn Rath, Tamme Goecke, Christian Opländer, Till Braunschweig, Petra Mela, Tim H Brümmendorf, Fabian Beier, Sabine Neuss
BACKGROUND: Studies in which mesenchymal stromal cells (MSC) from the placenta are compared with multiple MSC types from other sources are rare. The chorionic plate of the human placenta is mainly composed of fetal blood vessels embedded in fetal stroma tissue, lined by trophoblastic cells and organized into chorionic villi (CV) structures. METHODS: We comprehensively characterized human MSC collected from postnatal human chorionic villi of placenta (CV-MSC) by analyzing their growth and proliferation potential, differentiation, immunophenotype, extracellular matrix production, telomere length, aging phenotype, and plasticity...
February 5, 2018: Stem Cell Research & Therapy
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