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https://www.readbyqxmd.com/read/27816022/lesser-tuberosity-osteotomy-and-subscapularis-tenotomy-repair-techniques-during-total-shoulder-arthroplasty-a-meta-analysis-of-cadaveric-studies
#1
John B Schrock, Matthew J Kraeutler, Darby A Houck, Gina G Provenzano, Eric C McCarty, Jonathan T Bravman
BACKGROUND: Numerous techniques have been used to mobilize and repair the subscapularis tendon during total shoulder arthroplasty. The purpose of this study is to perform a detailed comparison of subscapularis tenotomy and lesser tuberosity osteotomy repairs during total shoulder arthroplasty. METHODS: Two independent reviewers searched two databases (PubMed and the Cochrane Library) to find cadaveric studies comparing the biomechanical strength of various subscapularis repair techniques following total shoulder arthroplasty...
October 27, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27493817/morel-lavall%C3%A3-e-lesion-of-the-knee-in-a-recreational-frisbee-player
#2
Alison Shmerling, Jonathan T Bravman, Morteza Khodaee
Traumatic swelling/effusion in the knee region is a relatively common presenting complaint among athletes and nonathletes. Due to its broad differential diagnosis, a comprehensive evaluation beginning with history and physical examination are recommended. Knee joint effusion can be differentiated from other types of swelling by careful physical examination. Imaging, including plain radiography, ultrasound, and magnetic resonance imaging (MRI), is preferred modality. Aspiration of a local fluctuating mass may help with the diagnosis and management of some of these conditions...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/26614471/biceps-tenotomy-versus-tenodesis
#3
REVIEW
Kushal V Patel, Jonathan Bravman, Armando Vidal, Ashley Chrisman, Eric McCarty
Long head biceps tendon is a common cause of anterior shoulder pain. Failure of conservative treatment may warrant surgical intervention. Surgical treatment involves long head biceps tenotomy or tenodesis. Several different techniques have been described for biceps tenodesis, including arthroscopic versus open and suprapectoral versus subpectoral. Most studies comparing tenodesis to tenotomy are limited by the level of evidence and confounding factors, such as concomitant rotator cuff tear. Many studies demonstrate similar outcomes for both procedures...
January 2016: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/26034858/fpin-s-clinical-inquiries-management-of-acute-achilles-tendon-rupture
#4
Luke Miller, Jack Spittler, Morteza Khodaee, Jonathan T Bravman, Corey Lyon, Lilian Hoffecker
No abstract text is available yet for this article.
June 1, 2015: American Family Physician
https://www.readbyqxmd.com/read/25970369/unicortical-versus-bicortical-locked-plate-fixation-in-midshaft-clavicle-fractures
#5
COMPARATIVE STUDY
Jonathan T Bravman, Michal L Taylor, Todd Baldini, Armando F Vidal
Higher rates of poor outcomes in displaced midshaft clavicle fractures treated nonoperatively have recently been reported. Along with expanding indications for operative fixation and increasing application of locked plate constructs, it is unknown whether complications related to bicortical penetration of the clavicle can be avoided using unicortical fixation. The purpose of this study is to compare the biomechanical properties of unicortical and bicortical fixation in precontoured vs manually contoured locking clavicle plates...
May 2015: Orthopedics
https://www.readbyqxmd.com/read/25174538/can-hip-arthroscopy-be-performed-with-conventional-knee-length-instrumentation
#6
Cecilia Pascual-Garrido, Mark O McConkey, David A Young, Jonathan T Bravman, Omer Mei-Dan
PURPOSE: The purpose of this study was to determine whether hip arthroscopy can be performed using conventional knee-length arthroscopy instrumentation. METHODS: We included 116 consecutive hip arthroscopies (104 patients) in this study. Age, side of surgery, height (in inches), weight (in pounds), body mass index (BMI), and a subjective assessment of body type (1, muscular; 2, somewhat overweight; 3, overweight; 4, thin; and 5, normal weight) were recorded. The depth from the skin at 2 portal sites to 3 commonly accessed positions (12 o'clock, 3 o'clock, and acetabular fossa) was assessed using a guide with marked notches (in millimeters)...
December 2014: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/24762832/percutaneous-femoral-derotational-osteotomy-for-excessive-femoral-torsion
#7
Omer Mei-Dan, Mark O McConkey, Jonathan T Bravman, David A Young, Cecilia Pascual-Garrido
Femoral derotational osteotomy is an acceptable treatment for excessive femoral torsion. The described procedure is a minimally invasive single-incision technique based on an intramedullary saw that enables an inside-out osteotomy, preserving the periosteum and biological activity in the local bone and soft tissue. After the osteotomy is complete and correction is achieved, an expandable intramedullary nail is used to achieve immediate stability, without the need for locking screws. Indications, tips, and pitfalls related to this novel osteotomy technique are discussed...
April 2014: Orthopedics
https://www.readbyqxmd.com/read/23756851/successful-lcl-reconstruction-and-pcl-repair-for-lcl-tear-and-pcl-avulsion-following-total-knee-arthroplasty
#8
Michael A Flierl, Jonathan T Bravman, Donald G Eckhoff
Total knee arthroplasty represents a well-established and successful procedure; however, ligament incompetence is known to negatively affect surgical outcomes. Here we present an unusual case of early total knee arthroplasty failure secondary to femoral posterior cruciate ligament (PCL) avulsion and associated lateral collateral ligament (LCL) tear, treated successfully with primary PCL repair and LCL reconstruction. For LCL reconstruction, a peroneus longus allograft was passed through an anterior to posterior bony tunnel in the fibular head and docked into a horizontal femoral tunnel...
November 2014: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/23585484/bone-patellar-tendon-bone-autograft-versus-allograft-in-outcomes-of-anterior-cruciate-ligament-reconstruction-a-meta-analysis-of-5182-patients
#9
COMPARATIVE STUDY
Matthew J Kraeutler, Jonathan T Bravman, Eric C McCarty
BACKGROUND: Bone-patellar tendon-bone (BPTB) is a common autograft and allograft source used for anterior cruciate ligament (ACL) reconstruction. Although the failure rate is generally higher for allografts, donor site morbidity and anterior knee pain can be issues with BPTB autografts. Controversy exists regarding the functional outcomes, complications, and knee stability of these grafts, previous comparisons of which have been based on smaller samples of case series. PURPOSE: To compare BPTB autografts to allografts for ACL reconstruction, specifically with regard to patient satisfaction, return to preinjury activity level, and postoperative functional outcomes...
October 2013: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/23457066/obesity-and-osteoarthritis-more-than-just-wear-and-tear
#10
REVIEW
Ryan C Koonce, Jonathan T Bravman
A link has been established between obesity and osteoarthritis (OA), but the precise relationship has yet to be defined. OA has a multifactorial etiology, and obesity is consistently identified as an independent and modifiable risk factor. The biomechanical relationship is intuitive: increased loads on articular cartilage cause subsequent wear and cartilage breakdown. Less intuitive, and possibly more important, are the systemic effects of obesity on OA. Promising investigations into relationships between lipid metabolism and OA have been rarely reported in the orthopaedic literature...
March 2013: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/20807286/butyrylcholinesterase-interactions-with-amylin-may-protect-pancreatic-cells-in-metabolic-syndrome
#11
Shani Shenhar-Tsarfaty, Tal Bruck, Estelle R Bennett, Tsafrir Bravman, Einor Ben Aassayag, Nir Waiskopf, Ori Rogowski, Natan Bornstein, Shlomo Berliner, Hermona Soreq
The metabolic syndrome (MetS) is a risk factor for type 2 diabetes mellitus (T2DM). However, the mechanisms underlying the transition from MetS to T2DM are unknown. Our goal was to study the potential contribution of butyrylcholinesterase (BChE) to this process. We first determined the hydrolytic activity of BChE in serum from MetS, T2DM and healthy individuals. The 'Kalow' variant of BChE (BChE-K), which has been proposed to be a risk factor for T2DM, was genotyped in the last two groups. Our results show that in MetS patients serum BChE activity is elevated compared to T2DM patients and healthy controls (P < 0...
August 2011: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/20624370/therapeutic-antibodies-discovery-and-development-using-the-proteon-xpr36-biosensor-interaction-array-system
#12
Vered Bronner, Galit Denkberg, Mira Peled, Yael Elbaz, Efrat Zahavi, Harel Kasoto, Yoram Reiter, Ariel Notcovich, Tsafrir Bravman
Therapeutic monoclonal antibodies are becoming a significant and rapidly growing class of therapeutic pharmaceuticals. Their discovery and development requires fast and high-throughput methodologies for screening and selecting appropriate candidate antibodies having high affinity for the target as well as high specificity and low cross-reactivity. This study demonstrates the use of the ProteOn XPR36 protein interaction array system and its novel approach, termed One-Shot Kinetics, for the rapid screening and selection of high-affinity antibodies...
November 15, 2010: Analytical Biochemistry
https://www.readbyqxmd.com/read/20000243/midshaft-clavicle-fractures-are-surgical-indications-changing
#13
Jonathan T Bravman, Armando F Vidal
No abstract text is available yet for this article.
December 2009: Orthopedics
https://www.readbyqxmd.com/read/19133223/a-global-benchmark-study-using-affinity-based-biosensors
#14
Rebecca L Rich, Giuseppe A Papalia, Peter J Flynn, Jamie Furneisen, John Quinn, Joshua S Klein, Phini S Katsamba, M Brent Waddell, Michael Scott, Joshua Thompson, Judie Berlier, Schuyler Corry, Mireille Baltzinger, Gabrielle Zeder-Lutz, Andreas Schoenemann, Anca Clabbers, Sebastien Wieckowski, Mary M Murphy, Phillip Page, Thomas E Ryan, Jay Duffner, Tanmoy Ganguly, John Corbin, Satyen Gautam, Gregor Anderluh, Andrej Bavdek, Dana Reichmann, Satya P Yadav, Eric Hommema, Ewa Pol, Andrew Drake, Scott Klakamp, Trevor Chapman, Dawn Kernaghan, Ken Miller, Jason Schuman, Kevin Lindquist, Kara Herlihy, Michael B Murphy, Richard Bohnsack, Bruce Andrien, Pietro Brandani, Danny Terwey, Rohn Millican, Ryan J Darling, Liann Wang, Quincy Carter, Joe Dotzlaf, Jacinto Lopez-Sagaseta, Islay Campbell, Paola Torreri, Sylviane Hoos, Patrick England, Yang Liu, Yasmina Abdiche, Daniel Malashock, Alanna Pinkerton, Melanie Wong, Eileen Lafer, Cynthia Hinck, Kevin Thompson, Carmelo Di Primo, Alison Joyce, Jonathan Brooks, Federico Torta, Anne Birgitte Bagge Hagel, Janus Krarup, Jesper Pass, Monica Ferreira, Sergei Shikov, Malgorzata Mikolajczyk, Yuki Abe, Gaetano Barbato, Anthony M Giannetti, Ganeshram Krishnamoorthy, Bianca Beusink, Daulet Satpaev, Tiffany Tsang, Eric Fang, James Partridge, Stephen Brohawn, James Horn, Otto Pritsch, Gonzalo Obal, Sanjay Nilapwar, Ben Busby, Gerardo Gutierrez-Sanchez, Ruchira Das Gupta, Sylvie Canepa, Krista Witte, Zaneta Nikolovska-Coleska, Yun Hee Cho, Roberta D'Agata, Kristian Schlick, Rosy Calvert, Eva M Munoz, Maria Jose Hernaiz, Tsafir Bravman, Monica Dines, Min-Hsiang Yang, Agnes Puskas, Erica Boni, Jiejin Li, Martin Wear, Asya Grinberg, Jason Baardsnes, Olan Dolezal, Melicia Gainey, Henrik Anderson, Jinlin Peng, Mark Lewis, Peter Spies, Quyhn Trinh, Sergei Bibikov, Jill Raymond, Mohammed Yousef, Vidya Chandrasekaran, Yuguo Feng, Anne Emerick, Suparna Mundodo, Rejane Guimaraes, Katy McGirr, Yue-Ji Li, Heather Hughes, Hubert Mantz, Rostislav Skrabana, Mark Witmer, Joshua Ballard, Loic Martin, Petr Skladal, George Korza, Ite Laird-Offringa, Charlene S Lee, Abdelkrim Khadir, Frank Podlaski, Phillippe Neuner, Julie Rothacker, Ashique Rafique, Nico Dankbar, Peter Kainz, Erk Gedig, Momchilo Vuyisich, Christina Boozer, Nguyen Ly, Mark Toews, Aykut Uren, Oleksandr Kalyuzhniy, Kenneth Lewis, Eugene Chomey, Brian J Pak, David G Myszka
To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amenable to analysis using different biosensor platforms as well as by users of different expertise levels. The two proteins (a 50-kDa Fab and a 60-kDa glutathione S-transferase [GST] antigen) form a relatively high-affinity complex, so participants needed to optimize several experimental parameters, including ligand immobilization and regeneration conditions as well as analyte concentrations and injection/dissociation times...
March 15, 2009: Analytical Biochemistry
https://www.readbyqxmd.com/read/19032757/vascular-injuries-after-minor-blunt-upper-extremity-trauma-pitfalls-in-the-recognition-and-diagnosis-of-potential-near-miss-injuries
#15
Jonathan T Bravman, Kyros Ipaktchi, Walter L Biffl, Philip F Stahel
BACKGROUND: Low energy trauma to the upper extremity is rarely associated with a significant vascular injury. Due to the low incidence, a high level of suspicion combined with appropriate diagnostic algorithms are mandatory for early recognition and timely management of these potentially detrimental injuries. METHODS: Review of the pertinent literature, supported by the presentation of two representative "near miss" case examples. RESULTS: A major diagnostic pitfall is represented by the insidious presentation of significant upper extremity arterial injuries with intact pulses and normal capillary refill distal to the injury site, due to collateral perfusion...
2008: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/18782554/parallel-kinetic-analysis-and-affinity-determination-of-hundreds-of-monoclonal-antibodies-using-the-proteon-xpr36
#16
Oded Nahshol, Vered Bronner, Ariel Notcovich, Laetitia Rubrecht, Daniel Laune, Tsafrir Bravman
The production of antibodies for diagnostic and therapeutic applications is a major focus for biotechnology and pharmaceutical companies, and it requires the development of fast, high-throughput methodologies for screening and selecting appropriate candidate antibodies for development. These candidates must have very high affinity for the target as well as high specificity and low cross-reactivity. This study demonstrates the use of the ProteOn XPR 36 protein interaction array system for the rapid screening and selection of high-affinity antibodies--"one-shot" kinetics...
December 1, 2008: Analytical Biochemistry
https://www.readbyqxmd.com/read/18719108/molecular-basis-of-the-interaction-between-the-antiapoptotic-bcl-2-family-proteins-and-the-proapoptotic-protein-aspp2
#17
Chen Katz, Hadar Benyamini, Shahar Rotem, Mario Lebendiker, Tsafi Danieli, Anat Iosub, Hadar Refaely, Monica Dines, Vered Bronner, Tsafrir Bravman, Deborah E Shalev, Stefan Rüdiger, Assaf Friedler
We have characterized the molecular basis of the interaction between ASPP2 and Bcl-2, which are key proteins in the apoptotic pathway. The C-terminal ankyrin repeats and SH3 domain of ASPP2 (ASPP2(Ank-SH3)) mediate its interactions with the antiapoptotic protein Bcl-2. We used biophysical and computational methods to identify the interaction sites of Bcl-2 and its homologues with ASPP2. Using peptide array screening, we found that ASPP2(Ank-SH3) binds two homologous sites in all three Bcl proteins tested: (i) the conserved BH4 motif, and (ii) a binding site for proapoptotic regulators...
August 26, 2008: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/18408762/methyl-jasmonate-binds-to-and-detaches-mitochondria-bound-hexokinase
#18
N Goldin, L Arzoine, A Heyfets, A Israelson, Z Zaslavsky, T Bravman, V Bronner, A Notcovich, V Shoshan-Barmatz, E Flescher
Cellular bio-energetic metabolism and mitochondria are recognized as potential targets for anticancer agents, due to the numerous relevant peculiarities cancer cells exhibit. Jasmonates are anticancer agents that interact directly with mitochondria. The aim of this study was to identify mitochondrial molecular targets of jasmonates. We report that jasmonates bind to hexokinase and detach it from the mitochondria and its mitochondrial anchor-the voltage-dependent anion channel (VDAC), as judged by hexokinase immunochemical and activity determinations, surface plasmon resonance analysis and planar lipid bilayer VDAC-activity analysis...
August 7, 2008: Oncogene
https://www.readbyqxmd.com/read/17955483/glycosynthase-activity-of-geobacillus-stearothermophilus-gh52-beta-xylosidase-efficient-synthesis-of-xylooligosaccharides-from-alpha-d-xylopyranosyl-fluoride-through-a-conjugated-reaction
#19
Alon Ben-David, Tsafrir Bravman, Yael S Balazs, Mirjam Czjzek, Dietmar Schomburg, Gil Shoham, Yuval Shoham
Glycosynthases are mutant glycosidases in which the acidic nucleophile is replaced by a small inert residue. In the presence of glycosyl fluorides of the opposite anomeric configuration (to that of their natural substrates), these enzymes can catalyze glycosidic bond formation with various acceptors. In this study we demonstrate that XynB2E335G, a nucleophile-deficient mutant of a glycoside hydrolase family 52 beta-xylosidase from G. stearothermophilus, can function as an efficient glycosynthase, using alpha-D-xylopyranosyl fluoride as a donor and various aryl sugars as acceptors...
November 23, 2007: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/17735848/elimination-of-current-dissipation-in-high-transition-temperature-superconductors
#20
J Z Sun, B Lairson, C B Eom, J Bravman, T H Geballe
The relaxation of the shielding current-induced magnetic moment in YBa(2)Cu(3)O(7) thin films, which were grown in situ, is studied as a function of temperature. Although typical relaxations cause a large amount of decay in the magnetic shielding current (on the order of 10 to 20 percent for the first 1000 seconds), it is shown that this is not necessarily a serious problem for applications such as magnets operating in persistent-current modes. This is because the decay of the magnetic shielding current depends sensitively on how far away the operating current density is from the critical current density J(c)...
January 19, 1990: Science
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